JP7109784B2 - 遺伝子編集のための進化したＣａｓ９蛋白質 - Google Patents

遺伝子編集のための進化したＣａｓ９蛋白質 Download PDF

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JP7109784B2
JP7109784B2 JP2018521045A JP2018521045A JP7109784B2 JP 7109784 B2 JP7109784 B2 JP 7109784B2 JP 2018521045 A JP2018521045 A JP 2018521045A JP 2018521045 A JP2018521045 A JP 2018521045A JP 7109784 B2 JP7109784 B2 JP 7109784B2
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cas9
amino acid
seq
protein
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JP2018537963A (ja
JP2018537963A5 (enExample
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リウ，デイビッド，アール．
フー，ジョニー，ハオ
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Harvard University
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JP2018521045A 2015-10-23 2016-10-22 遺伝子編集のための進化したＣａｓ９蛋白質 Active JP7109784B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022058736A JP7525174B2 (ja) 2015-10-23 2022-03-31 遺伝子編集のための進化したＣａｓ９蛋白質
JP2024058782A JP2024125281A (ja) 2015-10-23 2024-04-01 遺伝子編集のための進化したＣａｓ９蛋白質

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
US201562245828P 2015-10-23 2015-10-23
US62/245,828 2015-10-23
US201662279346P 2016-01-15 2016-01-15
US62/279,346 2016-01-15
US201662311763P 2016-03-22 2016-03-22
US62/311,763 2016-03-22
US201662322178P 2016-04-13 2016-04-13
US62/322,178 2016-04-13
US201662357352P 2016-06-30 2016-06-30
US201662357332P 2016-06-30 2016-06-30
US62/357,352 2016-06-30
US62/357,332 2016-06-30
US201662370700P 2016-08-03 2016-08-03
US62/370,700 2016-08-03
US201662398490P 2016-09-22 2016-09-22
US62/398,490 2016-09-22
US201662408686P 2016-10-14 2016-10-14
US62/408,686 2016-10-14
PCT/US2016/058345 WO2017070633A2 (en) 2015-10-23 2016-10-22 Evolved cas9 proteins for gene editing

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JP2018537963A JP2018537963A (ja) 2018-12-27
JP2018537963A5 JP2018537963A5 (enExample) 2020-02-27
JP7109784B2 true JP7109784B2 (ja) 2022-08-01

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JP2018521045A Active JP7109784B2 (ja) 2015-10-23 2016-10-22 遺伝子編集のための進化したＣａｓ９蛋白質
JP2018521096A Active JP7067793B2 (ja) 2015-10-23 2016-10-22 核酸塩基編集因子およびその使用
JP2022000227A Active JP7531923B2 (ja) 2015-10-23 2022-01-04 核酸塩基編集因子およびその使用
JP2022058736A Active JP7525174B2 (ja) 2015-10-23 2022-03-31 遺伝子編集のための進化したＣａｓ９蛋白質
JP2024058782A Pending JP2024125281A (ja) 2015-10-23 2024-04-01 遺伝子編集のための進化したＣａｓ９蛋白質
JP2024118365A Pending JP2024164012A (ja) 2015-10-23 2024-07-24 核酸塩基編集因子およびその使用

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JP2018521096A Active JP7067793B2 (ja) 2015-10-23 2016-10-22 核酸塩基編集因子およびその使用
JP2022000227A Active JP7531923B2 (ja) 2015-10-23 2022-01-04 核酸塩基編集因子およびその使用
JP2022058736A Active JP7525174B2 (ja) 2015-10-23 2022-03-31 遺伝子編集のための進化したＣａｓ９蛋白質
JP2024058782A Pending JP2024125281A (ja) 2015-10-23 2024-04-01 遺伝子編集のための進化したＣａｓ９蛋白質
JP2024118365A Pending JP2024164012A (ja) 2015-10-23 2024-07-24 核酸塩基編集因子およびその使用

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US (6) US12043852B2 (enExample)
EP (4) EP3365356B1 (enExample)
JP (6) JP7109784B2 (enExample)
KR (1) KR20180069898A (enExample)
CN (2) CN108513575A (enExample)
AU (3) AU2016342380B2 (enExample)
CA (1) CA3002827A1 (enExample)
IL (4) IL294014B2 (enExample)
SG (2) SG11201803173VA (enExample)
WO (2) WO2017070633A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022124487A (ja) * 2015-10-23 2022-08-25 プレジデント アンド フェローズ オブ ハーバード カレッジ 遺伝子編集のための進化したＣａｓ９蛋白質

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WO2013066438A2 (en) 2011-07-22 2013-05-10 President And Fellows Of Harvard College Evaluation and improvement of nuclease cleavage specificity
WO2013163628A2 (en) 2012-04-27 2013-10-31 Duke University Genetic correction of mutated genes
US9828582B2 (en) 2013-03-19 2017-11-28 Duke University Compositions and methods for the induction and tuning of gene expression
US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
US9737604B2 (en) 2013-09-06 2017-08-22 President And Fellows Of Harvard College Use of cationic lipids to deliver CAS9
US9340799B2 (en) 2013-09-06 2016-05-17 President And Fellows Of Harvard College MRNA-sensing switchable gRNAs
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US11053481B2 (en) 2013-12-12 2021-07-06 President And Fellows Of Harvard College Fusions of Cas9 domains and nucleic acid-editing domains
WO2015134121A2 (en) 2014-01-20 2015-09-11 President And Fellows Of Harvard College Negative selection and stringency modulation in continuous evolution systems
CN111471674A (zh) 2014-03-05 2020-07-31 国立大学法人神户大学 特异性转变靶向dna序列的核酸碱基的基因组序列的修饰方法、及其使用的分子复合体
EP3149156B1 (en) 2014-05-28 2021-02-17 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
IL286474B2 (en) 2014-06-23 2023-11-01 Massachusetts Gen Hospital Genome-wide random identification of DSBS assessed by sequencing (guide-sequence)
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JP2022124487A (ja) * 2015-10-23 2022-08-25 プレジデント アンド フェローズ オブ ハーバード カレッジ 遺伝子編集のための進化したＣａｓ９蛋白質
JP7525174B2 (ja) 2015-10-23 2024-07-30 プレジデント アンド フェローズ オブ ハーバード カレッジ 遺伝子編集のための進化したＣａｓ９蛋白質
JP2024125281A (ja) * 2015-10-23 2024-09-18 プレジデント アンド フェローズ オブ ハーバード カレッジ 遺伝子編集のための進化したＣａｓ９蛋白質

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