BR112017008082A2 - composições e métodos para detectar um vírus de rna - Google Patents
composições e métodos para detectar um vírus de rnaInfo
- Publication number
- BR112017008082A2 BR112017008082A2 BR112017008082A BR112017008082A BR112017008082A2 BR 112017008082 A2 BR112017008082 A2 BR 112017008082A2 BR 112017008082 A BR112017008082 A BR 112017008082A BR 112017008082 A BR112017008082 A BR 112017008082A BR 112017008082 A2 BR112017008082 A2 BR 112017008082A2
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- methods
- detecting
- rna virus
- rna
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6865—Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
a presente invenção fornece métodos para identificar rapidamente uma infecção viral de rna com o uso de uma reação de amplificação de ácido nucleico isotérmico que pode ser executada no rna extraído no contexto de uma amostra biológica bruta.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462066277P | 2014-10-20 | 2014-10-20 | |
US201562104008P | 2015-01-15 | 2015-01-15 | |
PCT/US2015/056491 WO2016064894A2 (en) | 2014-10-20 | 2015-10-20 | Compositions and methods for detecting an rna virus |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017008082A2 true BR112017008082A2 (pt) | 2017-12-26 |
Family
ID=55761744
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017008082A BR112017008082A2 (pt) | 2014-10-20 | 2015-10-20 | composições e métodos para detectar um vírus de rna |
Country Status (10)
Country | Link |
---|---|
US (2) | US10793922B2 (pt) |
EP (2) | EP3209802B1 (pt) |
JP (2) | JP2017536813A (pt) |
CN (1) | CN107208137A (pt) |
AU (2) | AU2015336086C1 (pt) |
BR (1) | BR112017008082A2 (pt) |
CA (1) | CA2965137A1 (pt) |
HK (1) | HK1243463A1 (pt) |
MX (1) | MX2017005159A (pt) |
WO (1) | WO2016064894A2 (pt) |
Families Citing this family (35)
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EP3613852A3 (en) | 2011-07-22 | 2020-04-22 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
CN114134207A (zh) | 2012-04-09 | 2022-03-04 | 一龙公司 | 用于量化样品中核酸序列的组合物和方法 |
US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
US20150166982A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting pi3k point mutations |
BR112016024622A2 (pt) | 2014-04-22 | 2017-10-10 | Envirologix Inc | composições e métodos para melhorar e/ou prever a amplificação de dna |
WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
JP7109784B2 (ja) | 2015-10-23 | 2022-08-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 遺伝子編集のための進化したCas9蛋白質 |
US11832801B2 (en) * | 2016-07-11 | 2023-12-05 | Arizona Board Of Regents On Behalf Of Arizona State University | Sweat as a biofluid for analysis and disease identification |
WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
WO2018071868A1 (en) | 2016-10-14 | 2018-04-19 | President And Fellows Of Harvard College | Aav delivery of nucleobase editors |
WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
KR20190127797A (ko) | 2017-03-10 | 2019-11-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 시토신에서 구아닌으로의 염기 편집제 |
KR20190140918A (ko) * | 2017-03-15 | 2019-12-20 | 더 브로드 인스티튜트, 인코퍼레이티드 | 바이러스 검출을 위한 crispr 이펙터 시스템 기반 진단 |
CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
US11732274B2 (en) | 2017-07-28 | 2023-08-22 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE) |
US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
CA3082251A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
CN108588050B (zh) * | 2018-05-14 | 2021-06-25 | 北京艾克伦医疗科技有限公司 | Dna聚合酶以及核酸检测方法和试剂盒 |
CN109593863A (zh) * | 2018-11-28 | 2019-04-09 | 江南大学 | 一种链置换型dna聚合酶诱导等温循环扩增反应检测肉类来源的方法 |
MX2021011426A (es) | 2019-03-19 | 2022-03-11 | Broad Inst Inc | Metodos y composiciones para editar secuencias de nucleótidos. |
CN111424116B (zh) * | 2020-03-19 | 2023-06-23 | 首都儿科研究所 | 用于检测黄热病毒疫苗株的rt-lamp试剂盒及其专用引物和应用 |
CN111334610B (zh) * | 2020-03-20 | 2023-11-14 | 广东省妇幼保健院 | 一种登革病毒通用型rt-raa-lfd扩增引物及检测方法 |
CN111471797B (zh) * | 2020-04-16 | 2023-05-12 | 广东省实验动物监测所 | 用于检测猫冠状病毒的rt-rpa引物对、探针、试剂盒及检测方法 |
IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
US20230279511A1 (en) * | 2020-07-10 | 2023-09-07 | The Rockefeller University | Method and system for saliva testing for virus including covid-19 |
JP2022060807A (ja) * | 2020-10-05 | 2022-04-15 | キヤノンメディカルシステムズ株式会社 | 乾燥試薬、試薬キット、乾燥試薬の製造方法、分析方法及び核酸増幅方法 |
CN116574844B (zh) * | 2023-03-01 | 2024-02-27 | 宁夏大学 | 一组检测牛病毒性腹泻病毒的rpa引物对、试剂盒和检测方法 |
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US5571639A (en) | 1994-05-24 | 1996-11-05 | Affymax Technologies N.V. | Computer-aided engineering system for design of sequence arrays and lithographic masks |
US6593086B2 (en) * | 1996-05-20 | 2003-07-15 | Mount Sinai School Of Medicine Of New York University | Nucleic acid amplification methods |
US5795716A (en) | 1994-10-21 | 1998-08-18 | Chee; Mark S. | Computer-aided visualization and analysis system for sequence evaluation |
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CA2849023C (en) * | 2011-09-15 | 2022-07-19 | David A. Shafer | Probe:antiprobe compositions for high specificity dna or rna detection |
US20130217071A1 (en) * | 2011-12-30 | 2013-08-22 | Luz Montesclaros | Methods and compositions for performing nucleic acid amplification reactions |
CN114134207A (zh) * | 2012-04-09 | 2022-03-04 | 一龙公司 | 用于量化样品中核酸序列的组合物和方法 |
CA2877368C (en) * | 2012-06-29 | 2021-07-13 | General Electric Company | Kit for isothermal dna amplification starting from an rna template |
JP2014082936A (ja) | 2012-10-19 | 2014-05-12 | Kyoto Univ | 変異型逆転写酵素 |
-
2015
- 2015-10-20 JP JP2017521095A patent/JP2017536813A/ja active Pending
- 2015-10-20 CA CA2965137A patent/CA2965137A1/en active Pending
- 2015-10-20 AU AU2015336086A patent/AU2015336086C1/en active Active
- 2015-10-20 WO PCT/US2015/056491 patent/WO2016064894A2/en active Application Filing
- 2015-10-20 EP EP15852795.2A patent/EP3209802B1/en not_active Revoked
- 2015-10-20 EP EP22187762.4A patent/EP4141128A1/en active Pending
- 2015-10-20 MX MX2017005159A patent/MX2017005159A/es unknown
- 2015-10-20 US US15/520,328 patent/US10793922B2/en active Active
- 2015-10-20 BR BR112017008082A patent/BR112017008082A2/pt unknown
- 2015-10-20 CN CN201580069867.5A patent/CN107208137A/zh active Pending
-
2018
- 2018-02-27 HK HK18102802.4A patent/HK1243463A1/zh unknown
-
2020
- 2020-08-12 US US16/991,216 patent/US20210025016A1/en active Pending
- 2020-11-13 JP JP2020189107A patent/JP7114676B2/ja active Active
-
2021
- 2021-03-03 AU AU2021201378A patent/AU2021201378B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA2965137A1 (en) | 2016-04-28 |
AU2015336086A1 (en) | 2017-05-11 |
JP7114676B2 (ja) | 2022-08-08 |
JP2021045140A (ja) | 2021-03-25 |
WO2016064894A3 (en) | 2016-06-09 |
EP3209802A2 (en) | 2017-08-30 |
AU2021201378B2 (en) | 2023-05-25 |
WO2016064894A2 (en) | 2016-04-28 |
AU2015336086B2 (en) | 2020-12-03 |
US20210025016A1 (en) | 2021-01-28 |
AU2021201378A1 (en) | 2021-03-18 |
HK1243463A1 (zh) | 2018-07-13 |
JP2017536813A (ja) | 2017-12-14 |
CN107208137A (zh) | 2017-09-26 |
US10793922B2 (en) | 2020-10-06 |
EP3209802A4 (en) | 2018-04-25 |
US20170327911A1 (en) | 2017-11-16 |
EP3209802B1 (en) | 2022-09-07 |
MX2017005159A (es) | 2017-08-18 |
AU2015336086C1 (en) | 2021-07-29 |
EP4141128A1 (en) | 2023-03-01 |
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B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] |