DK3090062T3 - Fusionsgener associeret med fremadskridende prostatakræft - Google Patents
Fusionsgener associeret med fremadskridende prostatakræft Download PDFInfo
- Publication number
- DK3090062T3 DK3090062T3 DK14875963.2T DK14875963T DK3090062T3 DK 3090062 T3 DK3090062 T3 DK 3090062T3 DK 14875963 T DK14875963 T DK 14875963T DK 3090062 T3 DK3090062 T3 DK 3090062T3
- Authority
- DK
- Denmark
- Prior art keywords
- prostate cancer
- genes associated
- fusion genes
- advanced prostate
- advanced
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361921836P | 2013-12-30 | 2013-12-30 | |
| US201462014487P | 2014-06-19 | 2014-06-19 | |
| US201462025923P | 2014-07-17 | 2014-07-17 | |
| PCT/US2014/072268 WO2015103057A1 (en) | 2013-12-30 | 2014-12-23 | Fusion genes associated with progressive prostate cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3090062T3 true DK3090062T3 (da) | 2020-09-21 |
Family
ID=53493928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14875963.2T DK3090062T3 (da) | 2013-12-30 | 2014-12-23 | Fusionsgener associeret med fremadskridende prostatakræft |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US9932641B2 (da) |
| EP (1) | EP3090062B1 (da) |
| CA (1) | CA2935216C (da) |
| DK (1) | DK3090062T3 (da) |
| ES (1) | ES2818625T3 (da) |
| WO (1) | WO2015103057A1 (da) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US20130079241A1 (en) | 2011-09-15 | 2013-03-28 | Jianhua Luo | Methods for Diagnosing Prostate Cancer and Predicting Prostate Cancer Relapse |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| EP3090062B1 (en) | 2013-12-30 | 2020-08-26 | University of Pittsburgh - of the Commonwealth System of Higher Education | Fusion genes associated with progressive prostate cancer |
| WO2016011428A1 (en) * | 2014-07-17 | 2016-01-21 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods of treating cells containing fusion genes |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| EP4273782A3 (en) * | 2015-07-25 | 2023-12-27 | Frost, Habib | A system, device and a method for providing a therapy or a cure for cancer and other pathological states |
| WO2017027473A1 (en) * | 2015-08-07 | 2017-02-16 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Methods for predicting prostate cancer relapse |
| WO2017070633A2 (en) | 2015-10-23 | 2017-04-27 | President And Fellows Of Harvard College | Evolved cas9 proteins for gene editing |
| SG11201900907YA (en) | 2016-08-03 | 2019-02-27 | Harvard College | Adenosine nucleobase editors and uses thereof |
| EP3497214B1 (en) | 2016-08-09 | 2023-06-28 | President and Fellows of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| CA3039928A1 (en) | 2016-10-14 | 2018-04-19 | President And Fellows Of Harvard College | Aav delivery of nucleobase editors |
| CN110234773A (zh) * | 2016-12-13 | 2019-09-13 | 匹兹堡大学联邦系统高等教育 | 治疗含融合基因的癌症的方法 |
| EP3554557A4 (en) | 2016-12-13 | 2020-07-29 | University of Pittsburgh - of The Commonwealth System of Higher Education | METHOD FOR TREATING CELLS CONTAINING FUSION GENES BY GENOMIC TARGETING |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| IL306092A (en) | 2017-03-23 | 2023-11-01 | Harvard College | Nucleic base editors that include nucleic acid programmable DNA binding proteins |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| US11732274B2 (en) | 2017-07-28 | 2023-08-22 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE) |
| US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
| WO2019079347A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | USES OF BASIC EDITORS ADENOSINE |
| US10769783B2 (en) * | 2018-02-09 | 2020-09-08 | Case Western Reserve University | Predicting prostate cancer biochemical recurrence using combined nuclear NF-KB/P65 localization and gland morphology |
| KR102229255B1 (ko) | 2018-12-28 | 2021-03-19 | 경북대학교 산학협력단 | 전립선 암 예후 예측용 바이오마커, 조성물, 키트, 및 이를 이용한 전립선 암 예후 예측 방법 및 전립선 암의 예방 또는 치료용 물질 스크리닝 방법 |
| AU2020242032A1 (en) | 2019-03-19 | 2021-10-07 | Massachusetts Institute Of Technology | Methods and compositions for editing nucleotide sequences |
| KR20230019843A (ko) | 2020-05-08 | 2023-02-09 | 더 브로드 인스티튜트, 인코퍼레이티드 | 표적 이중 가닥 뉴클레오티드 서열의 두 가닥의 동시 편집을 위한 방법 및 조성물 |
| CN115227834A (zh) * | 2022-06-02 | 2022-10-25 | 中国人民解放军海军军医大学 | 通过基因编辑技术联合dna损伤修复抑制剂特异杀伤癌细胞的方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005106041A2 (en) | 2004-04-22 | 2005-11-10 | The University Of Utah | Kits and reagents for use in diagnosis and prognosis of genomic disorders |
| WO2008016374A2 (en) | 2005-12-14 | 2008-02-07 | Cold Spring Harbor Laboratory | Methods for assessing probabilistic measures of clinical outcome using genomic profiling |
| FI20060751A0 (fi) * | 2006-08-23 | 2006-08-23 | Valtion Teknillinen | Menetelmä prostatasyövän hoitoon ja mainitusta menetelmästä hyödyntävien potilaiden seulonta |
| US8481572B2 (en) | 2007-08-09 | 2013-07-09 | Urifer Ltd. | Pharmaceutical compositions and methods for the treatment of cancer |
| CN107254538A (zh) | 2008-11-12 | 2017-10-17 | 卡里斯生命科学瑞士控股有限责任公司 | 使用外来体来确定表现型的方法和系统 |
| PT3130923T (pt) | 2008-11-14 | 2020-06-17 | Brigham & Womens Hospital Inc | Métodos terapêuticos relacionados com células estaminais |
| EP3133168B1 (en) | 2009-05-26 | 2019-01-23 | Quest Diagnostics Investments Incorporated | Methods for detecting gene dysregulations |
| US20130225420A1 (en) | 2010-08-02 | 2013-08-29 | The Regents Of The University Of California | Molecular subtyping of oral squamous cell carcinoma to distinguish a subtype that is unlikely to metastasize |
| CA2825545A1 (en) * | 2011-02-24 | 2012-08-30 | Ventana Medical Systems, Inc. | Presence of erg gene rearrangements and protein over-expression in low grade pin (lg-pin) in prostate biopsies |
| US20140296181A1 (en) | 2011-04-07 | 2014-10-02 | Coferon, Inc. | Methods of modulating oncogenic fusion proteins |
| US20130079241A1 (en) | 2011-09-15 | 2013-03-28 | Jianhua Luo | Methods for Diagnosing Prostate Cancer and Predicting Prostate Cancer Relapse |
| CN103797120B (zh) * | 2011-09-16 | 2017-04-12 | 上海长海医院 | 前列腺癌的生物学标志物、治疗靶点及其用途 |
| EP2877854B1 (en) | 2012-07-24 | 2022-09-07 | The Trustees of Columbia University in the City of New York | Fgfr-tacc fusion proteins and methods thereof |
| CN104781421B (zh) | 2012-09-04 | 2020-06-05 | 夸登特健康公司 | 检测稀有突变和拷贝数变异的系统和方法 |
| WO2014093701A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof |
| EP3090062B1 (en) | 2013-12-30 | 2020-08-26 | University of Pittsburgh - of the Commonwealth System of Higher Education | Fusion genes associated with progressive prostate cancer |
| US10745760B2 (en) | 2014-01-17 | 2020-08-18 | University Health Network | Biopsy-driven genomic signature for prostate cancer prognosis |
-
2014
- 2014-12-23 EP EP14875963.2A patent/EP3090062B1/en active Active
- 2014-12-23 ES ES14875963T patent/ES2818625T3/es active Active
- 2014-12-23 DK DK14875963.2T patent/DK3090062T3/da active
- 2014-12-23 WO PCT/US2014/072268 patent/WO2015103057A1/en active Application Filing
- 2014-12-23 CA CA2935216A patent/CA2935216C/en active Active
-
2016
- 2016-06-30 US US15/199,056 patent/US9932641B2/en active Active
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2018
- 2018-02-14 US US15/896,818 patent/US10167519B2/en active Active
- 2018-02-14 US US15/896,931 patent/US10344338B2/en active Active
- 2018-11-09 US US16/185,372 patent/US10570460B2/en active Active
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2019
- 2019-05-29 US US16/425,355 patent/US10988812B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2935216C (en) | 2021-11-09 |
| US20190360056A1 (en) | 2019-11-28 |
| US10344338B2 (en) | 2019-07-09 |
| US20160376666A1 (en) | 2016-12-29 |
| CA2935216A1 (en) | 2015-07-09 |
| US10988812B2 (en) | 2021-04-27 |
| EP3090062A1 (en) | 2016-11-09 |
| US9932641B2 (en) | 2018-04-03 |
| EP3090062A4 (en) | 2017-11-29 |
| US10167519B2 (en) | 2019-01-01 |
| WO2015103057A1 (en) | 2015-07-09 |
| US20180245162A1 (en) | 2018-08-30 |
| ES2818625T3 (es) | 2021-04-13 |
| US20190071733A1 (en) | 2019-03-07 |
| US10570460B2 (en) | 2020-02-25 |
| US20180187268A1 (en) | 2018-07-05 |
| EP3090062B1 (en) | 2020-08-26 |
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