CN114516920A - 用于基因编辑的cas变体 - Google Patents

用于基因编辑的cas变体 Download PDF

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CN114516920A
CN114516920A CN202210053406.0A CN202210053406A CN114516920A CN 114516920 A CN114516920 A CN 114516920A CN 202210053406 A CN202210053406 A CN 202210053406A CN 114516920 A CN114516920 A CN 114516920A
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D.R.刘
A.C.科莫尔
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Harvard University
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Harvard University
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CN202210053406.0A 2013-12-12 2014-12-12 用于基因编辑的cas变体 Pending CN114516920A (zh)

Applications Claiming Priority (20)

Application Number Priority Date Filing Date Title
US201361915386P 2013-12-12 2013-12-12
US61/915,386 2013-12-12
US201461980333P 2014-04-16 2014-04-16
US61/980,333 2014-04-16
US14/326,290 US20150166984A1 (en) 2013-12-12 2014-07-08 Methods for correcting alpha-antitrypsin point mutations
US14/326,318 2014-07-08
US14/326,140 2014-07-08
US14/326,109 2014-07-08
US14/326,109 US9840699B2 (en) 2013-12-12 2014-07-08 Methods for nucleic acid editing
US14/326,269 US9068179B1 (en) 2013-12-12 2014-07-08 Methods for correcting presenilin point mutations
US14/326,318 US20150166985A1 (en) 2013-12-12 2014-07-08 Methods for correcting von willebrand factor point mutations
US14/326,290 2014-07-08
US14/325,815 2014-07-08
US14/326,303 US20150165054A1 (en) 2013-12-12 2014-07-08 Methods for correcting caspase-9 point mutations
US14/326,140 US20150166982A1 (en) 2013-12-12 2014-07-08 Methods for correcting pi3k point mutations
US14/325,815 US11053481B2 (en) 2013-12-12 2014-07-08 Fusions of Cas9 domains and nucleic acid-editing domains
US14/326,269 2014-07-08
US14/326,303 2014-07-08
CN201480072550.2A CN105934516B (zh) 2013-12-12 2014-12-12 用于基因编辑的cas变体
PCT/US2014/070038 WO2015089406A1 (en) 2013-12-12 2014-12-12 Cas variants for gene editing

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CN201480072550.2A Division CN105934516B (zh) 2013-12-12 2014-12-12 用于基因编辑的cas变体

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CN114516920A true CN114516920A (zh) 2022-05-20

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CN202210053406.0A Pending CN114516920A (zh) 2013-12-12 2014-12-12 用于基因编辑的cas变体
CN201480072550.2A Active CN105934516B (zh) 2013-12-12 2014-12-12 用于基因编辑的cas变体

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US (11) US20150165054A1 (https=)
EP (3) EP3604511B1 (https=)
JP (4) JP2017500035A (https=)
CN (2) CN114516920A (https=)
AU (4) AU2014362208B2 (https=)
CA (1) CA2933625C (https=)
DK (2) DK3604511T3 (https=)
ES (1) ES2754433T3 (https=)
HU (1) HUE046398T2 (https=)
PL (1) PL3080265T3 (https=)
PT (1) PT3080265T (https=)
WO (1) WO2015089406A1 (https=)

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EP3241902B1 (en) 2012-05-25 2018-02-28 The Regents of The University of California Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
CA3109801C (en) 2013-08-22 2024-01-09 Andrew Cigan Plant genome modification using guide rna/cas endonuclease systems and methods of use
US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
US9526784B2 (en) 2013-09-06 2016-12-27 President And Fellows Of Harvard College Delivery system for functional nucleases
US9388430B2 (en) 2013-09-06 2016-07-12 President And Fellows Of Harvard College Cas9-recombinase fusion proteins and uses thereof
US9340799B2 (en) 2013-09-06 2016-05-17 President And Fellows Of Harvard College MRNA-sensing switchable gRNAs
WO2015066119A1 (en) 2013-10-30 2015-05-07 North Carolina State University Compositions and methods related to a type-ii crispr-cas system in lactobacillus buchneri
AU2014346559B2 (en) 2013-11-07 2020-07-09 Editas Medicine,Inc. CRISPR-related methods and compositions with governing gRNAs
US20150165054A1 (en) 2013-12-12 2015-06-18 President And Fellows Of Harvard College Methods for correcting caspase-9 point mutations
US10787654B2 (en) 2014-01-24 2020-09-29 North Carolina State University Methods and compositions for sequence guiding Cas9 targeting
PL3102722T3 (pl) 2014-02-04 2021-03-08 Jumpcode Genomics, Inc. Frakcjonowanie genomu
SG11201609211VA (en) 2014-03-05 2016-12-29 Nat Univ Corp Univ Kobe Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same
WO2015134812A1 (en) 2014-03-05 2015-09-11 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa
US11339437B2 (en) 2014-03-10 2022-05-24 Editas Medicine, Inc. Compositions and methods for treating CEP290-associated disease
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