BR112016030852A2 - encapsulação de rna mensageiro - Google Patents

encapsulação de rna mensageiro

Info

Publication number
BR112016030852A2
BR112016030852A2 BR112016030852A BR112016030852A BR112016030852A2 BR 112016030852 A2 BR112016030852 A2 BR 112016030852A2 BR 112016030852 A BR112016030852 A BR 112016030852A BR 112016030852 A BR112016030852 A BR 112016030852A BR 112016030852 A2 BR112016030852 A2 BR 112016030852A2
Authority
BR
Brazil
Prior art keywords
mrna
encapsulation
solution
lipid
messenger
Prior art date
Application number
BR112016030852A
Other languages
English (en)
Inventor
Derosa Frank
Heartlein Michael
Karve Shrirang
Original Assignee
Shire Human Genetic Therapies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53718162&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112016030852(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shire Human Genetic Therapies filed Critical Shire Human Genetic Therapies
Publication of BR112016030852A2 publication Critical patent/BR112016030852A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars

Abstract

a presente invenção fornece um processo melhorado para a formulação de nanopartícula de lipídeo e encapsulação de mrna. em algumas modalidades, a presente invenção proporciona um processo de encapsular rna mensageiro (mrna) em nanopartículas de lipídeos compreendendo uma etapa de misturar uma solução de mrna e uma solução de lipídeo, em que a solução de mrna e/ou a solução de lipídeo estão a uma temperatura predeterminada maior do que a temperatura ambiente.
BR112016030852A 2014-07-02 2015-07-02 encapsulação de rna mensageiro BR112016030852A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462020163P 2014-07-02 2014-07-02
PCT/US2015/039004 WO2016004318A1 (en) 2014-07-02 2015-07-02 Encapsulation of messenger rna

Publications (1)

Publication Number Publication Date
BR112016030852A2 true BR112016030852A2 (pt) 2018-01-16

Family

ID=53718162

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016030852A BR112016030852A2 (pt) 2014-07-02 2015-07-02 encapsulação de rna mensageiro

Country Status (8)

Country Link
US (4) US9668980B2 (pt)
EP (1) EP3164112A1 (pt)
JP (4) JP6782171B2 (pt)
CN (3) CN114344275A (pt)
AU (3) AU2015283954B2 (pt)
BR (1) BR112016030852A2 (pt)
CA (1) CA2953265C (pt)
WO (1) WO2016004318A1 (pt)

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