CN114516920A - 用于基因编辑的cas变体 - Google Patents

用于基因编辑的cas变体 Download PDF

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CN114516920A
CN114516920A CN202210053406.0A CN202210053406A CN114516920A CN 114516920 A CN114516920 A CN 114516920A CN 202210053406 A CN202210053406 A CN 202210053406A CN 114516920 A CN114516920 A CN 114516920A
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D.R.刘
A.C.科莫尔
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Harvard University
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CN202210053406.0A 2013-12-12 2014-12-12 用于基因编辑的cas变体 Pending CN114516920A (zh)

Applications Claiming Priority (20)

Application Number Priority Date Filing Date Title
US201361915386P 2013-12-12 2013-12-12
US61/915,386 2013-12-12
US201461980333P 2014-04-16 2014-04-16
US61/980,333 2014-04-16
US14/325,815 US11053481B2 (en) 2013-12-12 2014-07-08 Fusions of Cas9 domains and nucleic acid-editing domains
US14/326,318 US20150166985A1 (en) 2013-12-12 2014-07-08 Methods for correcting von willebrand factor point mutations
US14/326,303 US20150165054A1 (en) 2013-12-12 2014-07-08 Methods for correcting caspase-9 point mutations
US14/325,815 2014-07-08
US14/326,303 2014-07-08
US14/326,109 US9840699B2 (en) 2013-12-12 2014-07-08 Methods for nucleic acid editing
US14/326,140 US20150166982A1 (en) 2013-12-12 2014-07-08 Methods for correcting pi3k point mutations
US14/326,140 2014-07-08
US14/326,109 2014-07-08
US14/326,290 2014-07-08
US14/326,318 2014-07-08
US14/326,269 US9068179B1 (en) 2013-12-12 2014-07-08 Methods for correcting presenilin point mutations
US14/326,290 US20150166984A1 (en) 2013-12-12 2014-07-08 Methods for correcting alpha-antitrypsin point mutations
US14/326,269 2014-07-08
PCT/US2014/070038 WO2015089406A1 (en) 2013-12-12 2014-12-12 Cas variants for gene editing
CN201480072550.2A CN105934516B (zh) 2013-12-12 2014-12-12 用于基因编辑的cas变体

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CN201480072550.2A Division CN105934516B (zh) 2013-12-12 2014-12-12 用于基因编辑的cas变体

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CN114516920A true CN114516920A (zh) 2022-05-20

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CN202210053406.0A Pending CN114516920A (zh) 2013-12-12 2014-12-12 用于基因编辑的cas变体

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US (11) US11053481B2 (enExample)
EP (3) EP3080265B1 (enExample)
JP (4) JP2017500035A (enExample)
CN (2) CN105934516B (enExample)
AU (2) AU2014362208B2 (enExample)
CA (1) CA2933625C (enExample)
DK (2) DK3080265T3 (enExample)
ES (1) ES2754433T3 (enExample)
HU (1) HUE046398T2 (enExample)
PL (1) PL3080265T3 (enExample)
PT (1) PT3080265T (enExample)
WO (1) WO2015089406A1 (enExample)

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EP3613852A3 (en) 2011-07-22 2020-04-22 President and Fellows of Harvard College Evaluation and improvement of nuclease cleavage specificity
RS59199B1 (sr) 2012-05-25 2019-10-31 Univ California Metode i jedinjenja za rnk-upravljanu ciljanu dnk modifikaciju i za rnk- upravljanu modulaciju transkripta
US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
CN120574876A (zh) 2013-08-22 2025-09-02 纳幕尔杜邦公司 使用向导rna/cas内切核酸酶系统的植物基因组修饰及其使用方法
US9228207B2 (en) 2013-09-06 2016-01-05 President And Fellows Of Harvard College Switchable gRNAs comprising aptamers
US9388430B2 (en) 2013-09-06 2016-07-12 President And Fellows Of Harvard College Cas9-recombinase fusion proteins and uses thereof
US9737604B2 (en) 2013-09-06 2017-08-22 President And Fellows Of Harvard College Use of cationic lipids to deliver CAS9
WO2015066119A1 (en) 2013-10-30 2015-05-07 North Carolina State University Compositions and methods related to a type-ii crispr-cas system in lactobacillus buchneri
CN111218447B (zh) 2013-11-07 2024-10-11 爱迪塔斯医药有限公司 使用统治型gRNA的CRISPR相关方法和组合物
US11053481B2 (en) 2013-12-12 2021-07-06 President And Fellows Of Harvard College Fusions of Cas9 domains and nucleic acid-editing domains
US10787654B2 (en) 2014-01-24 2020-09-29 North Carolina State University Methods and compositions for sequence guiding Cas9 targeting
PL3102722T3 (pl) 2014-02-04 2021-03-08 Jumpcode Genomics, Inc. Frakcjonowanie genomu
EP3613854A1 (en) * 2014-03-05 2020-02-26 National University Corporation Kobe University Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same
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