CN101460619B - 核苷酸链的修饰方法 - Google Patents
核苷酸链的修饰方法 Download PDFInfo
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- CN101460619B CN101460619B CN200780020081XA CN200780020081A CN101460619B CN 101460619 B CN101460619 B CN 101460619B CN 200780020081X A CN200780020081X A CN 200780020081XA CN 200780020081 A CN200780020081 A CN 200780020081A CN 101460619 B CN101460619 B CN 101460619B
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- nucleotide
- nucleotide chain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
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- Proteomics, Peptides & Aminoacids (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
核苷酸的碱基 | 适用的DNA糖苷酶·DNA修复酶 |
·尿嘧啶·5-羟基尿嘧啶·5,6-二羟基尿嘧啶·5-氟尿嘧啶 | ·尿嘧啶DNA糖苷酶 |
·次黄嘌呤 | ·次黄嘌呤DNA糖苷酶 |
·3-甲基腺嘌呤·3-乙基腺嘌呤 | ·3-甲基腺嘌呤DNA糖苷酶I型 |
·3-甲基腺嘌呤·次黄嘌呤·3-甲基鸟嘌呤·7-甲基鸟嘌呤·1,N6-桥亚乙基腺嘌呤·8-氧鸟嘌呤·7-乙基嘌呤·3-乙基嘌呤·7,3-二乙基嘌呤·1-羧乙基腺嘌呤·7-羧乙基鸟嘌呤·O2-甲基嘧啶·7-(2-乙氧基乙基)鸟嘌呤·7-(2-羟基乙基)鸟嘌呤·7-(2-氯乙基)鸟嘌呤·1,2-双(7-脒基)乙烷·3-乙硫基乙基嘌呤·N2,3-桥亚乙基鸟嘌呤·N2,3-亚乙烯基鸟嘌呤·5-羟甲基尿嘧啶·5-甲酰基尿嘧啶·1,N4-亚乙烯基胞嘧啶·1,N2-亚乙烯基鸟嘌呤·3,N2-亚乙烯基鸟嘌呤 | ·3-甲基腺嘌呤DNA糖苷酶II型 |
·胸腺嘧啶二醇·5,6-二氢胸腺嘧啶·5,6-二羟基二氢胸腺嘧啶·羟基胞嘧啶·尿素·5-羟基-5-甲基乙内酰脲·6-羟基-5,6-二羟基嘧啶·5-羟基尿嘧啶·5-羟基-6-氢胸腺嘧啶·5,6-二氢尿嘧啶·尿嘧啶二醇·5-羟基-6-氢尿嘧啶 | ·核酸内切酶III |
·8-氧鸟嘌呤·7,8-二氢-8-氧鸟嘌呤·8-氧腺嘌呤·甲酰氨基鸟嘌呤·甲基甲酰氨基鸟嘌呤 | ·8-氧鸟嘌呤DNA糖苷酶 |
·7-甲基鸟嘌呤·1,6-二氨基-5-甲酰氨基嘧啶·甲酰氨基鸟嘌呤·甲基甲酰氨基鸟嘌呤·甲酰氨基腺嘌呤·8-氧腺嘌呤·8-氧鸟嘌呤·7,8-二氢-8-氧鸟嘌呤·羟基胞嘧啶·5-羟基尿嘧啶·黄曲霉素结合咪唑开环状鸟嘌呤·咪唑开环状N-2-氨基芴-8-鸟嘌呤 | ·甲酰氨基嘧啶DNA糖苷酶 |
·8-氧鸟嘌呤·腺嘌呤/鸟嘌呤错配 | ·MutY-DNA糖苷酶 |
·1,N4-亚乙烯基胞嘧啶·尿嘧啶/鸟嘌呤错配 | ·错配尿嘧啶DNA糖苷酶 |
·嘧啶二聚体 | ·嘧啶二聚体DNA糖苷酶 |
·胸腺嘧啶/鸟嘌呤错配·鸟嘌呤/鸟嘌呤错配 | ·胸腺嘧啶DNA糖苷酶 |
氯化钴 | 氯化镁 | 氯化锰 |
(+) | (-) | (-) |
Claims (9)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP156731/2006 | 2006-06-06 | ||
JP2006156731 | 2006-06-06 | ||
PCT/JP2007/061309 WO2007142202A1 (ja) | 2006-06-06 | 2007-06-04 | ヌクレオチド鎖修飾方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101460619A CN101460619A (zh) | 2009-06-17 |
CN101460619B true CN101460619B (zh) | 2012-07-25 |
Family
ID=38801453
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200780020081XA Expired - Fee Related CN101460619B (zh) | 2006-06-06 | 2007-06-04 | 核苷酸链的修饰方法 |
Country Status (5)
Country | Link |
---|---|
US (1) | US8129115B2 (zh) |
EP (1) | EP2028272B1 (zh) |
JP (1) | JP4823310B2 (zh) |
CN (1) | CN101460619B (zh) |
WO (1) | WO2007142202A1 (zh) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2853829C (en) | 2011-07-22 | 2023-09-26 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
SG11201900907YA (en) * | 2016-08-03 | 2019-02-27 | Harvard College | Adenosine nucleobase editors and uses thereof |
WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
BR112021018607A2 (pt) | 2019-03-19 | 2021-11-23 | Massachusetts Inst Technology | Métodos e composições para editar sequências de nucleotídeos |
CN116096873A (zh) | 2020-05-08 | 2023-05-09 | 布罗德研究所股份有限公司 | 同时编辑靶标双链核苷酸序列的两条链的方法和组合物 |
CN112920247B (zh) * | 2021-01-22 | 2022-12-27 | 南京大学 | 一种利用糖苷酶和氧胺化合物修饰dna的方法 |
US20220381984A1 (en) * | 2021-05-31 | 2022-12-01 | Jinan University | Fiber optic sensing apparatus and system |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1170412A (zh) * | 1994-11-02 | 1998-01-14 | Icn药品公司 | 糖修饰的核苷和它们用于合成低聚核苷酸的应用 |
CN1687100A (zh) * | 2005-04-05 | 2005-10-26 | 奥林格斯技术有限公司 | 修饰性核苷酸及其用途 |
CN1780909A (zh) * | 2003-06-30 | 2006-05-31 | 松下电器产业株式会社 | 核苷酸链修饰方法 |
Family Cites Families (21)
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CA1219824A (en) | 1981-04-17 | 1987-03-31 | David C. Ward | Modified nucleotides and methods of preparing and using same |
US4711955A (en) | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
JPS5862600A (ja) | 1981-10-09 | 1983-04-14 | 富士写真フイルム株式会社 | 帯電防止層を有するx線螢光増感紙 |
CA1223831A (en) | 1982-06-23 | 1987-07-07 | Dean Engelhardt | Modified nucleotides, methods of preparing and utilizing and compositions containing the same |
JPS59148798A (ja) | 1983-02-14 | 1984-08-25 | Wakunaga Seiyaku Kk | ビオチンヌクレオチド誘導体 |
JPS5993100A (ja) | 1983-10-31 | 1984-05-29 | Wakunaga Seiyaku Kk | オリゴヌクレオチド誘導体 |
JPS60166695A (ja) | 1984-02-09 | 1985-08-29 | Wakunaga Seiyaku Kk | オリゴヌクレオチド誘導体およびその製造法 |
JPS61112093A (ja) | 1984-11-05 | 1986-05-30 | Wakunaga Seiyaku Kk | ヌクレオチド誘導体 |
US4828979A (en) | 1984-11-08 | 1989-05-09 | Life Technologies, Inc. | Nucleotide analogs for nucleic acid labeling and detection |
JPH05331185A (ja) | 1992-05-29 | 1993-12-14 | Nippon Millipore Kogyo Kk | 核酸rnaの3′末端標識 |
US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
DE69825722T2 (de) | 1998-02-04 | 2005-08-25 | Corning Inc. | Substrat zum Drucken einer Matrize |
DE19812103A1 (de) | 1998-03-19 | 1999-09-23 | Bernauer Annette | Verfahren zur Synthese von Nucleinsäuremolekülen |
JP2000063154A (ja) | 1998-08-12 | 2000-02-29 | Mitsubishi Chemicals Corp | 核酸固定用ガラスプレート |
GB9905807D0 (en) | 1999-03-12 | 1999-05-05 | Amersham Pharm Biotech Uk Ltd | Analysis of differential gene expression |
JP2001066304A (ja) | 1999-06-21 | 2001-03-16 | Nisshinbo Ind Inc | 核酸固定化基板 |
JP2003161731A (ja) | 2001-11-27 | 2003-06-06 | Sumitomo Bakelite Co Ltd | マイクロチップ用プラスチック基板、その製造方法及びその使用方法 |
JP2003246794A (ja) * | 2002-02-26 | 2003-09-02 | Matsushita Kotobuki Electronics Industries Ltd | ヌクレオチド鎖修飾方法 |
JP2004101516A (ja) * | 2002-07-19 | 2004-04-02 | Canon Inc | プローブ担体およびその製造方法 |
US20070077629A1 (en) * | 2003-06-30 | 2007-04-05 | Shigeki Joko | Method for modifying nucleotide chain |
US20070218478A1 (en) * | 2005-12-16 | 2007-09-20 | Affymetrix, Inc. | Methods for fragmentation and analysis of nucleic acid |
-
2007
- 2007-06-04 EP EP07744668.0A patent/EP2028272B1/en not_active Not-in-force
- 2007-06-04 JP JP2008520567A patent/JP4823310B2/ja not_active Expired - Fee Related
- 2007-06-04 WO PCT/JP2007/061309 patent/WO2007142202A1/ja active Application Filing
- 2007-06-04 CN CN200780020081XA patent/CN101460619B/zh not_active Expired - Fee Related
- 2007-06-04 US US12/303,313 patent/US8129115B2/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1170412A (zh) * | 1994-11-02 | 1998-01-14 | Icn药品公司 | 糖修饰的核苷和它们用于合成低聚核苷酸的应用 |
CN1780909A (zh) * | 2003-06-30 | 2006-05-31 | 松下电器产业株式会社 | 核苷酸链修饰方法 |
CN1687100A (zh) * | 2005-04-05 | 2005-10-26 | 奥林格斯技术有限公司 | 修饰性核苷酸及其用途 |
Also Published As
Publication number | Publication date |
---|---|
US20100015670A1 (en) | 2010-01-21 |
WO2007142202A1 (ja) | 2007-12-13 |
EP2028272B1 (en) | 2014-01-08 |
JP4823310B2 (ja) | 2011-11-24 |
EP2028272A4 (en) | 2010-09-22 |
US8129115B2 (en) | 2012-03-06 |
EP2028272A1 (en) | 2009-02-25 |
JPWO2007142202A1 (ja) | 2009-10-22 |
CN101460619A (zh) | 2009-06-17 |
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Owner name: PANASONIC HEALTHCARE + MEDICAL EQUIPMENT CO., LTD. Free format text: FORMER OWNER: MATSUSHITA ELECTRIC INDUSTRIAL CO, LTD. Effective date: 20140527 |
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Effective date of registration: 20140527 Address after: Ehime Prefecture, Japan Patentee after: Panasonic Healthcare Co., Ltd Address before: Japan Osaka Patentee before: Matsushita Electric Industrial Co., Ltd. |
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Owner name: PANASONIC HEALTHCARE HOLDINGS CO., LTD. Free format text: FORMER OWNER: PANASONIC HEALTHCARE + MEDICAL EQUIPMENT CO., LTD. Effective date: 20150402 |
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Effective date of registration: 20150402 Address after: Tokyo, Japan Patentee after: Panasonic's health medical treatment is controlled interest Co., Ltd. Address before: Ehime Prefecture, Japan Patentee before: Panasonic Healthcare Co., Ltd |
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120725 Termination date: 20160604 |