|
US4217344A
(en)
|
1976-06-23 |
1980-08-12 |
L'oreal |
Compositions containing aqueous dispersions of lipid spheres
|
|
US4235871A
(en)
|
1978-02-24 |
1980-11-25 |
Papahadjopoulos Demetrios P |
Method of encapsulating biologically active materials in lipid vesicles
|
|
US4186183A
(en)
|
1978-03-29 |
1980-01-29 |
The United States Of America As Represented By The Secretary Of The Army |
Liposome carriers in chemotherapy of leishmaniasis
|
|
US4182449A
(en)
|
1978-04-18 |
1980-01-08 |
Kozlow William J |
Adhesive bandage and package
|
|
US4261975A
(en)
|
1979-09-19 |
1981-04-14 |
Merck & Co., Inc. |
Viral liposome particle
|
|
US4663290A
(en)
|
1982-01-21 |
1987-05-05 |
Molecular Genetics, Inc. |
Production of reverse transcriptase
|
|
US4485054A
(en)
|
1982-10-04 |
1984-11-27 |
Lipoderm Pharmaceuticals Limited |
Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
|
|
US4501728A
(en)
|
1983-01-06 |
1985-02-26 |
Technology Unlimited, Inc. |
Masking of liposomes from RES recognition
|
|
US4880635B1
(en)
|
1984-08-08 |
1996-07-02 |
Liposome Company |
Dehydrated liposomes
|
|
US4946787A
(en)
|
1985-01-07 |
1990-08-07 |
Syntex (U.S.A.) Inc. |
N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US5049386A
(en)
|
1985-01-07 |
1991-09-17 |
Syntex (U.S.A.) Inc. |
N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US4897355A
(en)
|
1985-01-07 |
1990-01-30 |
Syntex (U.S.A.) Inc. |
N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US4797368A
(en)
|
1985-03-15 |
1989-01-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
Adeno-associated virus as eukaryotic expression vector
|
|
US4921757A
(en)
|
1985-04-26 |
1990-05-01 |
Massachusetts Institute Of Technology |
System for delayed and pulsed release of biologically active substances
|
|
US4774085A
(en)
|
1985-07-09 |
1988-09-27 |
501 Board of Regents, Univ. of Texas |
Pharmaceutical administration systems containing a mixture of immunomodulators
|
|
US5139941A
(en)
|
1985-10-31 |
1992-08-18 |
University Of Florida Research Foundation, Inc. |
AAV transduction vectors
|
|
US4737323A
(en)
|
1986-02-13 |
1988-04-12 |
Liposome Technology, Inc. |
Liposome extrusion method
|
|
US5017492A
(en)
|
1986-02-27 |
1991-05-21 |
Life Technologies, Inc. |
Reverse transcriptase and method for its production
|
|
EP0264166B1
(en)
|
1986-04-09 |
1996-08-21 |
Genzyme Corporation |
Transgenic animals secreting desired proteins into milk
|
|
US5374553A
(en)
|
1986-08-22 |
1994-12-20 |
Hoffmann-La Roche Inc. |
DNA encoding a thermostable nucleic acid polymerase enzyme from thermotoga maritima
|
|
US4889818A
(en)
|
1986-08-22 |
1989-12-26 |
Cetus Corporation |
Purified thermostable enzyme
|
|
US5079352A
(en)
|
1986-08-22 |
1992-01-07 |
Cetus Corporation |
Purified thermostable enzyme
|
|
US4920016A
(en)
|
1986-12-24 |
1990-04-24 |
Linear Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US4837028A
(en)
|
1986-12-24 |
1989-06-06 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
JPH0825869B2
(ja)
|
1987-02-09 |
1996-03-13 |
株式会社ビタミン研究所 |
抗腫瘍剤包埋リポソ−ム製剤
|
|
US4917951A
(en)
|
1987-07-28 |
1990-04-17 |
Micro-Pak, Inc. |
Lipid vesicles formed of surfactants and steroids
|
|
US4911928A
(en)
|
1987-03-13 |
1990-03-27 |
Micro-Pak, Inc. |
Paucilamellar lipid vesicles
|
|
BR8807472A
(pt)
|
1987-04-23 |
1990-03-27 |
Fmc Corp |
Composto,composicao inseticida,processo de controle de insetos e acarideos e processo para preparacao de um composto
|
|
US4873316A
(en)
|
1987-06-23 |
1989-10-10 |
Biogen, Inc. |
Isolation of exogenous recombinant proteins from the milk of transgenic mammals
|
|
US5244797B1
(en)
|
1988-01-13 |
1998-08-25 |
Life Technologies Inc |
Cloned genes encoding reverse transcriptase lacking rnase h activity
|
|
FR2632821B1
(fr)
|
1988-06-22 |
1990-11-16 |
Inst Kriobiologii |
Procede de conservation a basse temperature des embryons
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
ATE151110T1
(de)
|
1988-09-02 |
1997-04-15 |
Protein Eng Corp |
Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen
|
|
US5270179A
(en)
|
1989-08-10 |
1993-12-14 |
Life Technologies, Inc. |
Cloning and expression of T5 DNA polymerase reduced in 3'- to-5' exonuclease activity
|
|
US5047342A
(en)
|
1989-08-10 |
1991-09-10 |
Life Technologies, Inc. |
Cloning and expression of T5 DNA polymerase
|
|
US5264618A
(en)
|
1990-04-19 |
1993-11-23 |
Vical, Inc. |
Cationic lipids for intracellular delivery of biologically active molecules
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
WO1991017424A1
(en)
|
1990-05-03 |
1991-11-14 |
Vical, Inc. |
Intracellular delivery of biologically active substances by means of self-assembling lipid complexes
|
|
US5580737A
(en)
|
1990-06-11 |
1996-12-03 |
Nexstar Pharmaceuticals, Inc. |
High-affinity nucleic acid ligands that discriminate between theophylline and caffeine
|
|
US5637459A
(en)
|
1990-06-11 |
1997-06-10 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: chimeric selex
|
|
CA2090614C
(en)
|
1990-09-28 |
2001-12-11 |
David H. Gelfand |
5' to 3' exonuclease mutations of thermostable dna polymerases
|
|
EP0553264A4
(en)
|
1990-10-05 |
1994-07-13 |
Wayne M Barnes |
Thermostable dna polymerase
|
|
US5173414A
(en)
|
1990-10-30 |
1992-12-22 |
Applied Immune Sciences, Inc. |
Production of recombinant adeno-associated virus vectors
|
|
ES2315612T3
(es)
|
1991-04-10 |
2009-04-01 |
The Scripps Research Institute |
Genotecas de receptores heterodimericos usando fagemidos.
|
|
US6872816B1
(en)
|
1996-01-24 |
2005-03-29 |
Third Wave Technologies, Inc. |
Nucleic acid detection kits
|
|
JPH05274181A
(ja)
|
1992-03-25 |
1993-10-22 |
Nec Corp |
ブレークポイント設定・解除方式
|
|
US5587308A
(en)
|
1992-06-02 |
1996-12-24 |
The United States Of America As Represented By The Department Of Health & Human Services |
Modified adeno-associated virus vector capable of expression from a novel promoter
|
|
US5834247A
(en)
|
1992-12-09 |
1998-11-10 |
New England Biolabs, Inc. |
Modified proteins comprising controllable intervening protein sequences or their elements methods of producing same and methods for purification of a target protein comprised by a modified protein
|
|
US5496714A
(en)
|
1992-12-09 |
1996-03-05 |
New England Biolabs, Inc. |
Modification of protein by use of a controllable interveining protein sequence
|
|
US5434058A
(en)
|
1993-02-09 |
1995-07-18 |
Arch Development Corporation |
Apolipoprotein B MRNA editing protein compositions and methods
|
|
US5436149A
(en)
|
1993-02-19 |
1995-07-25 |
Barnes; Wayne M. |
Thermostable DNA polymerase with enhanced thermostability and enhanced length and efficiency of primer extension
|
|
EP0702716A4
(en)
|
1993-05-17 |
1999-05-26 |
Univ California |
RIBOZYMIC GENE THERAPY FOR HIV INFECTION AND AIDS
|
|
US5512462A
(en)
|
1994-02-25 |
1996-04-30 |
Hoffmann-La Roche Inc. |
Methods and reagents for the polymerase chain reaction amplification of long DNA sequences
|
|
US5651981A
(en)
|
1994-03-29 |
1997-07-29 |
Northwestern University |
Cationic phospholipids for transfection
|
|
US5912155A
(en)
|
1994-09-30 |
1999-06-15 |
Life Technologies, Inc. |
Cloned DNA polymerases from Thermotoga neapolitana
|
|
US5614365A
(en)
|
1994-10-17 |
1997-03-25 |
President & Fellow Of Harvard College |
DNA polymerase having modified nucleotide binding site for DNA sequencing
|
|
US5449639A
(en)
|
1994-10-24 |
1995-09-12 |
Taiwan Semiconductor Manufacturing Company Ltd. |
Disposable metal anti-reflection coating process used together with metal dry/wet etch
|
|
US5767099A
(en)
|
1994-12-09 |
1998-06-16 |
Genzyme Corporation |
Cationic amphiphiles containing amino acid or dervatized amino acid groups for intracellular delivery of therapeutic molecules
|
|
US6057153A
(en)
|
1995-01-13 |
2000-05-02 |
Yale University |
Stabilized external guide sequences
|
|
US5795587A
(en)
|
1995-01-23 |
1998-08-18 |
University Of Pittsburgh |
Stable lipid-comprising drug delivery complexes and methods for their production
|
|
US5830430A
(en)
|
1995-02-21 |
1998-11-03 |
Imarx Pharmaceutical Corp. |
Cationic lipids and the use thereof
|
|
US5851548A
(en)
|
1995-06-07 |
1998-12-22 |
Gen-Probe Incorporated |
Liposomes containing cationic lipids and vitamin D
|
|
US5773258A
(en)
|
1995-08-25 |
1998-06-30 |
Roche Molecular Systems, Inc. |
Nucleic acid amplification using a reversibly inactivated thermostable enzyme
|
|
US5962313A
(en)
|
1996-01-18 |
1999-10-05 |
Avigen, Inc. |
Adeno-associated virus vectors comprising a gene encoding a lyosomal enzyme
|
|
US6887707B2
(en)
|
1996-10-28 |
2005-05-03 |
University Of Washington |
Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA
|
|
GB9701425D0
(en)
|
1997-01-24 |
1997-03-12 |
Bioinvent Int Ab |
A method for in vitro molecular evolution of protein function
|
|
US5981182A
(en)
|
1997-03-13 |
1999-11-09 |
Albert Einstein College Of Medicine Of Yeshiva University |
Vector constructs for the selection and identification of open reading frames
|
|
US20040203109A1
(en)
|
1997-06-06 |
2004-10-14 |
Incyte Corporation |
Human regulatory proteins
|
|
US5849528A
(en)
|
1997-08-21 |
1998-12-15 |
Incyte Pharmaceuticals, Inc.. |
Polynucleotides encoding a human S100 protein
|
|
US6156509A
(en)
|
1997-11-12 |
2000-12-05 |
Genencor International, Inc. |
Method of increasing efficiency of directed evolution of a gene using phagemid
|
|
US6183998B1
(en)
|
1998-05-29 |
2001-02-06 |
Qiagen Gmbh Max-Volmer-Strasse 4 |
Method for reversible modification of thermostable enzymes
|
|
US8097648B2
(en)
|
1998-06-17 |
2012-01-17 |
Eisai R&D Management Co., Ltd. |
Methods and compositions for use in treating cancer
|
|
WO2000022115A2
(en)
|
1998-10-13 |
2000-04-20 |
Board Of Regents, The University Of Texas System |
Assays for identifying functional alterations in the p53 tumor suppressor
|
|
EP2298728A1
(en)
|
1998-11-12 |
2011-03-23 |
Life Technologies Corporation |
Transfection reagents
|
|
US7013219B2
(en)
|
1999-01-12 |
2006-03-14 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US6453242B1
(en)
|
1999-01-12 |
2002-09-17 |
Sangamo Biosciences, Inc. |
Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
|
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US6599692B1
(en)
|
1999-09-14 |
2003-07-29 |
Sangamo Bioscience, Inc. |
Functional genomics using zinc finger proteins
|
|
US20090130718A1
(en)
|
1999-02-04 |
2009-05-21 |
Diversa Corporation |
Gene site saturation mutagenesis
|
|
CA2365601A1
(en)
*
|
1999-03-29 |
2000-10-05 |
Kansai Technology Licensing Organization Co., Ltd. |
Novel cytidine deaminase
|
|
US6365410B1
(en)
|
1999-05-19 |
2002-04-02 |
Genencor International, Inc. |
Directed evolution of microorganisms
|
|
GB9920194D0
(en)
|
1999-08-27 |
1999-10-27 |
Advanced Biotech Ltd |
A heat-stable thermostable DNA polymerase for use in nucleic acid amplification
|
|
DE60043158D1
(de)
|
1999-11-18 |
2009-11-26 |
Pharmexa Inc |
Heteroklitische analoga von klasse-i epitopen
|
|
EP1235914A2
(en)
|
1999-11-24 |
2002-09-04 |
Joseph Rosenecker |
Polypeptides comprising multimers of nuclear localization signals or of protein transduction domains and their use for transferring molecules into cells
|
|
AU776576B2
(en)
|
1999-12-06 |
2004-09-16 |
Sangamo Biosciences, Inc. |
Methods of using randomized libraries of zinc finger proteins for the identification of gene function
|
|
WO2001059450A2
(en)
|
2000-02-08 |
2001-08-16 |
Sangamo Biosciences, Inc. |
Cells expressing zinc finger protein for drug discovery
|
|
US7378248B2
(en)
|
2000-03-06 |
2008-05-27 |
Rigel Pharmaceuticals, Inc. |
In vivo production of cyclic peptides for inhibiting protein-protein interaction
|
|
US7078208B2
(en)
|
2000-05-26 |
2006-07-18 |
Invitrogen Corporation |
Thermostable reverse transcriptases and uses thereof
|
|
US6573092B1
(en)
|
2000-10-10 |
2003-06-03 |
Genvec, Inc. |
Method of preparing a eukaryotic viral vector
|
|
ATE439372T1
(de)
|
2000-10-27 |
2009-08-15 |
Novartis Vaccines & Diagnostic |
Nukleinsäuren und proteine von gruppen a und b- streptokokken
|
|
EP2263658A1
(en)
|
2000-10-30 |
2010-12-22 |
Euro-Celtique S.A. |
Controlled release hydrocodone formulations
|
|
US20040003420A1
(en)
|
2000-11-10 |
2004-01-01 |
Ralf Kuhn |
Modified recombinase
|
|
ATE375394T1
(de)
|
2001-01-25 |
2007-10-15 |
Evolva Ltd |
Concatemere unterschiedlich exprimierter multipler gene
|
|
US20050222030A1
(en)
|
2001-02-21 |
2005-10-06 |
Anthony Allison |
Modified annexin proteins and methods for preventing thrombosis
|
|
ATE398180T1
(de)
|
2001-02-27 |
2008-07-15 |
Univ Rochester |
Verfahren und zusammensetzungen zur modifikation der bearbeitung von apolipoprotein b-mrna
|
|
JP2004537984A
(ja)
|
2001-04-19 |
2004-12-24 |
ザ スクリップス リサーチ インスティテュート |
直交tRNA−アミノアシルtRNAシンテターゼ対を生産するための方法及び組成物
|
|
EP1446757A2
(en)
|
2001-05-30 |
2004-08-18 |
Biomedical Center |
In silico screening for phenotype-associated expressed sequences
|
|
WO2003025118A2
(en)
|
2001-07-26 |
2003-03-27 |
Stratagene |
Multi-site mutagenesis
|
|
US20030167533A1
(en)
|
2002-02-04 |
2003-09-04 |
Yadav Narendra S. |
Intein-mediated protein splicing
|
|
DK1506288T3
(da)
|
2002-05-10 |
2013-07-22 |
Medical Res Council |
Aktiveringsinduceret deaminase (aid)
|
|
US9388459B2
(en)
|
2002-06-17 |
2016-07-12 |
Affymetrix, Inc. |
Methods for genotyping
|
|
US20040175719A1
(en)
|
2002-07-12 |
2004-09-09 |
Affymetrix, Inc. |
Synthetic tag genes
|
|
JP2006500030A
(ja)
|
2002-09-20 |
2006-01-05 |
イェール ユニバーシティ |
リボスイッチ、その使用方法、ならびにリボスイッチとともに用いるための組成物
|
|
EP1613962B1
(en)
|
2003-04-14 |
2008-10-29 |
Caliper Life Sciences, Inc. |
Reduction of migration shift assay interference
|
|
WO2005002527A2
(en)
|
2003-07-03 |
2005-01-13 |
Massachusetts Institute Of Technology |
Sirt1 modulation of adipogenesis and adipose function
|
|
AU2004267359B2
(en)
|
2003-07-07 |
2010-09-09 |
The Scripps Research Institute |
Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
|
|
ES2808687T3
(es)
|
2003-08-08 |
2021-03-01 |
Sangamo Therapeutics Inc |
Métodos y composiciones para escisión dirigida y recombinación
|
|
US7670807B2
(en)
|
2004-03-10 |
2010-03-02 |
East Tennessee State Univ. Research Foundation |
RNA-dependent DNA polymerase from Geobacillus stearothermophilus
|
|
US7192739B2
(en)
|
2004-03-30 |
2007-03-20 |
President And Fellows Of Harvard College |
Ligand-dependent protein splicing
|
|
US7595179B2
(en)
|
2004-04-19 |
2009-09-29 |
Applied Biosystems, Llc |
Recombinant reverse transcriptases
|
|
US7919277B2
(en)
|
2004-04-28 |
2011-04-05 |
Danisco A/S |
Detection and typing of bacterial strains
|
|
CA2632216C
(en)
|
2004-07-06 |
2013-11-12 |
Societe De Commercialisation Des Produits De La Recherche Appliquee Socpra Sciences Sante Et Humaines S.E.C. |
A target-dependent nucleic acid adapter
|
|
US8728526B2
(en)
|
2004-08-19 |
2014-05-20 |
The United States of America, Represented by Secretary of Department of Health and Human Services, NIH |
Coacervate microparticles useful for the sustained release administration of therapeutic agents
|
|
ATE514776T1
(de)
|
2004-10-05 |
2011-07-15 |
California Inst Of Techn |
Aptamer-regulierte nukleinsäuren und verwendungen davon
|
|
US8178291B2
(en)
|
2005-02-18 |
2012-05-15 |
Monogram Biosciences, Inc. |
Methods and compositions for determining hypersusceptibility of HIV-1 to non-nucleoside reverse transcriptase inhibitors
|
|
JP2006248978A
(ja)
|
2005-03-10 |
2006-09-21 |
Mebiopharm Co Ltd |
新規なリポソーム製剤
|
|
US9783791B2
(en)
|
2005-08-10 |
2017-10-10 |
Agilent Technologies, Inc. |
Mutant reverse transcriptase and methods of use
|
|
AU2015252023B2
(en)
|
2005-08-26 |
2017-06-29 |
Dupont Nutrition Biosciences Aps |
Use
|
|
NZ597299A
(en)
|
2005-08-26 |
2013-03-28 |
Dupont Nutrition Biosci Aps |
Use of a cas gene in combination with CRISPR repeats for modulating resistance in a cell
|
|
KR100784478B1
(ko)
|
2005-12-05 |
2007-12-11 |
한국과학기술원 |
기능요소의 동시 삽입에 의한 신기능을 갖는 단백질을제조하는 방법
|
|
US20080051317A1
(en)
|
2005-12-15 |
2008-02-28 |
George Church |
Polypeptides comprising unnatural amino acids, methods for their production and uses therefor
|
|
JP5364574B2
(ja)
|
2006-05-05 |
2013-12-11 |
モレキュラー、トランスファー、インコーポレイテッド |
真核細胞のトランスフェクションのための新規試薬
|
|
EP2018441B2
(en)
|
2006-05-19 |
2025-07-02 |
International N&H Denmark ApS |
Tagged microorganisms and methods of tagging
|
|
EP2030015B1
(en)
|
2006-06-02 |
2016-02-17 |
President and Fellows of Harvard College |
Protein surface remodeling
|
|
WO2008005529A2
(en)
|
2006-07-07 |
2008-01-10 |
The Trustees Columbia University In The City Of New York |
Cell-mediated directed evolution
|
|
CN101688241B
(zh)
|
2007-03-02 |
2015-01-21 |
杜邦营养生物科学有限公司 |
具有改善的噬菌体抗性的培养物
|
|
WO2009033027A2
(en)
|
2007-09-05 |
2009-03-12 |
Medtronic, Inc. |
Suppression of scn9a gene expression and/or function for the treatment of pain
|
|
WO2009042163A2
(en)
|
2007-09-27 |
2009-04-02 |
Sangamo Biosciences, Inc. |
Rapid in vivo identification of biologically active nucleases
|
|
US9029524B2
(en)
|
2007-12-10 |
2015-05-12 |
California Institute Of Technology |
Signal activated RNA interference
|
|
EP2087789A1
(en)
|
2008-02-06 |
2009-08-12 |
Heinrich-Heine-Universität Düsseldorf |
Fto-modified non-human mammal
|
|
CA2714378A1
(en)
|
2008-02-08 |
2009-08-13 |
Sangamo Biosciences, Inc. |
Treatment of chronic pain with zinc finger proteins
|
|
GB0806562D0
(en)
|
2008-04-10 |
2008-05-14 |
Fermentas Uab |
Production of nucleic acid
|
|
WO2009146179A1
(en)
|
2008-04-15 |
2009-12-03 |
University Of Iowa Research Foundation |
Zinc finger nuclease for the cftr gene and methods of use thereof
|
|
WO2009134808A2
(en)
|
2008-04-28 |
2009-11-05 |
President And Fellows Of Harvard College |
Supercharged proteins for cell penetration
|
|
WO2009132455A1
(en)
|
2008-04-30 |
2009-11-05 |
Paul Xiang-Qin Liu |
Protein splicing using short terminal split inteins
|
|
US8546553B2
(en)
|
2008-07-25 |
2013-10-01 |
University Of Georgia Research Foundation, Inc. |
Prokaryotic RNAi-like system and methods of use
|
|
JP2010033344A
(ja)
|
2008-07-29 |
2010-02-12 |
Azabu Jui Gakuen |
核酸構成塩基の偏在性を表す方法
|
|
EP2159286A1
(en)
|
2008-09-01 |
2010-03-03 |
Consiglio Nazionale Delle Ricerche |
Method for obtaining oligonucleotide aptamers and uses thereof
|
|
WO2010026537A1
(en)
|
2008-09-05 |
2010-03-11 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Novel multimodular assembly useful for intracellular delivery
|
|
EP3199630B1
(en)
|
2008-09-05 |
2019-05-08 |
President and Fellows of Harvard College |
Continuous directed evolution of proteins and nucleic acids
|
|
US8636884B2
(en)
|
2008-09-15 |
2014-01-28 |
Abbott Diabetes Care Inc. |
Cationic polymer based wired enzyme formulations for use in analyte sensors
|
|
US20100076057A1
(en)
|
2008-09-23 |
2010-03-25 |
Northwestern University |
TARGET DNA INTERFERENCE WITH crRNA
|
|
WO2010054108A2
(en)
|
2008-11-06 |
2010-05-14 |
University Of Georgia Research Foundation, Inc. |
Cas6 polypeptides and methods of use
|
|
WO2010054154A2
(en)
|
2008-11-07 |
2010-05-14 |
Danisco A/S |
Bifidobacteria crispr sequences
|
|
US20110016540A1
(en)
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Genome editing of genes associated with trinucleotide repeat expansion disorders in animals
|
|
US9175341B2
(en)
|
2008-12-11 |
2015-11-03 |
Pacific Biosciences Of California, Inc. |
Methods for identifying nucleic acid modifications
|
|
US9175338B2
(en)
|
2008-12-11 |
2015-11-03 |
Pacific Biosciences Of California, Inc. |
Methods for identifying nucleic acid modifications
|
|
WO2010075424A2
(en)
|
2008-12-22 |
2010-07-01 |
The Regents Of University Of California |
Compositions and methods for downregulating prokaryotic genes
|
|
US20100305197A1
(en)
|
2009-02-05 |
2010-12-02 |
Massachusetts Institute Of Technology |
Conditionally Active Ribozymes And Uses Thereof
|
|
US8389679B2
(en)
|
2009-02-05 |
2013-03-05 |
The Regents Of The University Of California |
Targeted antimicrobial moieties
|
|
CN102421791A
(zh)
|
2009-03-04 |
2012-04-18 |
得克萨斯系统大学评议会 |
稳定化逆转录酶融合蛋白
|
|
CA2754212C
(en)
|
2009-03-06 |
2016-08-02 |
Synthetic Genomics, Inc. |
Methods for cloning and manipulating genomes
|
|
CA2760155A1
(en)
|
2009-04-27 |
2010-11-11 |
Pacific Biosciences Of California, Inc. |
Real-time sequencing methods and systems
|
|
JP2012525146A
(ja)
|
2009-04-28 |
2012-10-22 |
プレジデント アンド フェロウズ オブ ハーバード カレッジ |
細胞透過のための過剰に荷電されたタンパク質
|
|
WO2010132092A2
(en)
|
2009-05-12 |
2010-11-18 |
The Scripps Research Institute |
Cytidine deaminase fusions and related methods
|
|
US9063156B2
(en)
|
2009-06-12 |
2015-06-23 |
Pacific Biosciences Of California, Inc. |
Real-time analytical methods and systems
|
|
CA2765488C
(en)
|
2009-06-30 |
2018-01-02 |
Sangamo Biosciences, Inc. |
Rapid screening of biologically active nucleases and isolation of nuclease-modified cells
|
|
WO2011000106A1
(en)
|
2009-07-01 |
2011-01-06 |
Protiva Biotherapeutics, Inc. |
Improved cationic lipids and methods for the delivery of therapeutic agents
|
|
US20120178647A1
(en)
|
2009-08-03 |
2012-07-12 |
The General Hospital Corporation |
Engineering of zinc finger arrays by context-dependent assembly
|
|
EP2462230B1
(en)
|
2009-08-03 |
2015-07-15 |
Recombinetics, Inc. |
Methods and compositions for targeted gene modification
|
|
GB0913681D0
(en)
|
2009-08-05 |
2009-09-16 |
Glaxosmithkline Biolog Sa |
Immunogenic composition
|
|
US8889394B2
(en)
|
2009-09-07 |
2014-11-18 |
Empire Technology Development Llc |
Multiple domain proteins
|
|
CA2779495C
(en)
|
2009-10-30 |
2019-04-30 |
Synthetic Genomics, Inc. |
Encoding text into nucleic acid sequences
|
|
CN106399276B
(zh)
|
2009-11-02 |
2021-08-10 |
华盛顿大学 |
治疗性核酸酶组合物和方法
|
|
US20110104787A1
(en)
|
2009-11-05 |
2011-05-05 |
President And Fellows Of Harvard College |
Fusion Peptides That Bind to and Modify Target Nucleic Acid Sequences
|
|
US20110142886A1
(en)
|
2009-12-01 |
2011-06-16 |
Intezyne Technologies, Incorporated |
Pegylated polyplexes for polynucleotide delivery
|
|
PL2506857T3
(pl)
|
2009-12-01 |
2018-09-28 |
Translate Bio, Inc. |
DOSTARCZANIE mRNA DLA ZWIĘKSZENIA ILOŚCI BIAŁEK I ENZYMÓW W LUDZKICH CHOROBACH GENETYCZNYCH
|
|
EP2510096B2
(en)
|
2009-12-10 |
2018-02-07 |
Regents of the University of Minnesota |
Tal effector-mediated dna modification
|
|
EP2513296A4
(en)
|
2009-12-18 |
2013-05-22 |
Univ Leland Stanford Junior |
USE OF CYTIDINE DAMINASE ASSOCIATED ACTIVITIES TO PROMOTE DEMETHYLATION AND CELL REPROGRAMMEIRING
|
|
AU2011207387B2
(en)
|
2010-01-22 |
2015-02-26 |
Corteva Agriscience Llc |
Excision of transgenes in genetically modified organisms
|
|
JP2013520989A
(ja)
|
2010-03-05 |
2013-06-10 |
シンセティック ジェノミクス インコーポレーテッド |
ゲノムのクローニングおよび操作のための方法
|
|
WO2011123830A2
(en)
|
2010-04-02 |
2011-10-06 |
Amunix Operating Inc. |
Alpha 1-antitrypsin compositions and methods of making and using same
|
|
JP5926242B2
(ja)
|
2010-05-10 |
2016-05-25 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
エンドリボヌクレアーゼ組成物およびその使用方法
|
|
KR101953237B1
(ko)
|
2010-05-17 |
2019-02-28 |
상가모 테라퓨틱스, 인코포레이티드 |
신규 dna 결합 단백질 및 이의 용도
|
|
GB201008267D0
(en)
|
2010-05-18 |
2010-06-30 |
Univ Edinburgh |
Cationic lipids
|
|
BR112012030522A2
(pt)
|
2010-05-27 |
2020-10-13 |
Heinrich-Pette-Institut Leibniz-Institut Fur Experimentelle Virologie - Stiftung Burgerlichen Rechts |
Método para preparo de um vetor de expressão que codifica uma recombinase configurada, método para preparo de uma célula transformada, ácido nucleico, recombinase configurada codificada pelo ácido nucleico, célula transformada ecomposição farmacêutica"
|
|
DK2575767T3
(en)
|
2010-06-04 |
2017-03-13 |
Sirna Therapeutics Inc |
HOWEVER UNKNOWN LOW MOLECULAR CATIONIC LIPIDS TO PROCESS OIGONUCLEOTIDES
|
|
AU2011265733B2
(en)
|
2010-06-14 |
2014-04-17 |
Iowa State University Research Foundation, Inc. |
Nuclease activity of TAL effector and Foki fusion protein
|
|
US8822663B2
(en)
|
2010-08-06 |
2014-09-02 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
EP2604688B1
(en)
|
2010-08-13 |
2018-01-10 |
Kyoto University |
Variant reverse transcriptase
|
|
EP2629913B1
(en)
|
2010-09-20 |
2020-08-26 |
SPI Pharma, INC. |
Microencapsulation process and product
|
|
EP2630156B1
(en)
|
2010-10-20 |
2018-08-22 |
DuPont Nutrition Biosciences ApS |
Lactococcus crispr-cas sequences
|
|
WO2012054727A1
(en)
|
2010-10-22 |
2012-04-26 |
Bio-Rad Laboratories, Inc. |
Reverse transcriptase mixtures with improved storage stability
|
|
CN103327970A
(zh)
|
2010-11-26 |
2013-09-25 |
约翰内斯堡威特沃特斯兰德大学 |
聚合物-脂质纳米粒子的聚合基质作为药物剂型
|
|
KR101255338B1
(ko)
|
2010-12-15 |
2013-04-16 |
포항공과대학교 산학협력단 |
표적 세포에 대한 폴리뉴클레오티드 전달체
|
|
EP2651400B2
(en)
|
2010-12-16 |
2023-01-18 |
Amgen (Europe) GmbH |
Controlled release oral dosage forms of poorly soluble drugs and uses thereof
|
|
WO2012088381A2
(en)
|
2010-12-22 |
2012-06-28 |
President And Fellows Of Harvard College |
Continuous directed evolution
|
|
US9499592B2
(en)
|
2011-01-26 |
2016-11-22 |
President And Fellows Of Harvard College |
Transcription activator-like effectors
|
|
KR101818126B1
(ko)
|
2011-02-09 |
2018-01-15 |
(주)바이오니아 |
열안정성이 증가된 역전사효소
|
|
US9528124B2
(en)
|
2013-08-27 |
2016-12-27 |
Recombinetics, Inc. |
Efficient non-meiotic allele introgression
|
|
US9200045B2
(en)
|
2011-03-11 |
2015-12-01 |
President And Fellows Of Harvard College |
Small molecule-dependent inteins and uses thereof
|
|
US9164079B2
(en)
|
2011-03-17 |
2015-10-20 |
Greyledge Technologies Llc |
Systems for autologous biological therapeutics
|
|
US20120244601A1
(en)
|
2011-03-22 |
2012-09-27 |
Bertozzi Carolyn R |
Riboswitch based inducible gene expression platform
|
|
US8709466B2
(en)
|
2011-03-31 |
2014-04-29 |
International Business Machines Corporation |
Cationic polymers for antimicrobial applications and delivery of bioactive materials
|
|
DK2694091T3
(da)
|
2011-04-05 |
2019-06-03 |
Cellectis |
Fremgangsmåde til fremstilling af kompakte tale-nukleaser og anvendelse heraf
|
|
WO2012148953A1
(en)
|
2011-04-25 |
2012-11-01 |
Stc.Unm |
Solid compositions for pharmaceutical use
|
|
AU2012249390B2
(en)
|
2011-04-27 |
2017-03-30 |
Amyris, Inc. |
Methods for genomic modification
|
|
WO2012158986A2
(en)
|
2011-05-17 |
2012-11-22 |
Transposagen Biopharmaceuticals, Inc. |
Methods for site-specific genetic modification in stem cells using xanthomonas tal nucleases (xtn) for the creation of model organisms
|
|
US8691750B2
(en)
|
2011-05-17 |
2014-04-08 |
Axolabs Gmbh |
Lipids and compositions for intracellular delivery of biologically active compounds
|
|
WO2012158985A2
(en)
|
2011-05-17 |
2012-11-22 |
Transposagen Biopharmaceuticals, Inc. |
Methods for site-specific genetic modification in spermatogonial stem cells using zinc finger nuclease (zfn) for the creation of model organisms
|
|
WO2012164565A1
(en)
|
2011-06-01 |
2012-12-06 |
Yeda Research And Development Co. Ltd. |
Compositions and methods for downregulating prokaryotic genes
|
|
CN103906527B
(zh)
|
2011-06-08 |
2020-07-10 |
川斯勒佰尔公司 |
Mrna递送的脂质纳米颗粒组合物和方法
|
|
JP6214530B2
(ja)
|
2011-07-15 |
2017-10-18 |
ザ ジェネラル ホスピタル コーポレイション |
転写活性化因子様エフェクターの組立て方法
|
|
WO2013013105A2
(en)
|
2011-07-19 |
2013-01-24 |
Vivoscript,Inc. |
Compositions and methods for re-programming cells without genetic modification for repairing cartilage damage
|
|
EP2734621B1
(en)
|
2011-07-22 |
2019-09-04 |
President and Fellows of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
EP3384938A1
(en)
|
2011-09-12 |
2018-10-10 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
EP2755986A4
(en)
|
2011-09-12 |
2015-05-20 |
Moderna Therapeutics Inc |
MANIPULATED NUCLEIC ACIDS AND METHOD OF APPLICATION THEREFOR
|
|
US9567589B2
(en)
|
2011-09-28 |
2017-02-14 |
Ribomic Inc. |
NGF aptamer and application thereof
|
|
KR102096534B1
(ko)
|
2011-09-28 |
2020-04-03 |
에라 바이오테크, 에스.에이. |
분할된 인테인 및 그의 이용
|
|
GB2496687A
(en)
|
2011-11-21 |
2013-05-22 |
Gw Pharma Ltd |
Tetrahydrocannabivarin (THCV) in the protection of pancreatic islet cells
|
|
DK2788487T3
(en)
|
2011-12-08 |
2018-07-23 |
Sarepta Therapeutics Inc |
Oligonucleotide Analogs Targeted against HUMAN LMNA
|
|
RU2663354C2
(ru)
|
2011-12-16 |
2018-08-03 |
Таргитджин Байотекнолоджиз Лтд |
Композиции и способы для модификации заданной последовательности нуклеиновой кислоты-мишени
|
|
RS63244B1
(sr)
|
2011-12-16 |
2022-06-30 |
Modernatx Inc |
Kompozicije modifikovane mrna
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
US9737480B2
(en)
|
2012-02-06 |
2017-08-22 |
President And Fellows Of Harvard College |
ARRDC1-mediated microvesicles (ARMMs) and uses thereof
|
|
AU2013222170B2
(en)
|
2012-02-24 |
2017-01-05 |
Fred Hutchinson Cancer Research Center |
Compositions and methods for the treatment of hemoglobinopathies
|
|
BR112014021104B1
(pt)
|
2012-02-29 |
2023-03-28 |
Sangamo Biosciences, Inc |
Proteína de fusão de ocorrência não natural compreendendo um domínio de ligação de dna de dedo de zinco manipulado que se liga a um gene htt, seu uso, método in vitro de modificação da expressão de um gene htt em uma célula, e método de geração de um sistema modelo para o estudo da doença de huntington
|
|
US20150086581A1
(en)
|
2012-03-17 |
2015-03-26 |
The Regents Of The University Of California |
Fast Diagnosis and Personalized Treatment for Acne
|
|
US9637739B2
(en)
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
|
WO2013141680A1
(en)
|
2012-03-20 |
2013-09-26 |
Vilnius University |
RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX
|
|
WO2013152359A1
(en)
|
2012-04-06 |
2013-10-10 |
The Regents Of The University Of California |
Novel tetrazines and method of synthesizing the same
|
|
US11518997B2
(en)
|
2012-04-23 |
2022-12-06 |
BASF Agricultural Solutions Seed US LLC |
Targeted genome engineering in plants
|
|
EP2844754B1
(en)
|
2012-05-02 |
2018-10-24 |
Dow AgroSciences LLC |
Targeted modification of malate dehydrogenase
|
|
AU2013259647B2
(en)
|
2012-05-07 |
2018-11-08 |
Corteva Agriscience Llc |
Methods and compositions for nuclease-mediated targeted integration of transgenes
|
|
WO2013169398A2
(en)
|
2012-05-09 |
2013-11-14 |
Georgia Tech Research Corporation |
Systems and methods for improving nuclease specificity and activity
|
|
US20150017136A1
(en)
|
2013-07-15 |
2015-01-15 |
Cellectis |
Methods for engineering allogeneic and highly active t cell for immunotherapy
|
|
WO2013176916A1
(en)
|
2012-05-25 |
2013-11-28 |
Roman Galetto |
Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells
|
|
BR112014029441B1
(pt)
|
2012-05-25 |
2022-10-18 |
Emmanuelle Charpentier |
Método de modificação de um dna alvo, composição, rna tendo como alvo dna, um ou mais ácidos nucleicos, kit, método para modular a transcrição específica do sítio em um dna alvo e método para modificar um polipeptídeo associado com um dna alvo
|
|
EP2854866A4
(en)
|
2012-05-30 |
2015-12-23 |
Baylor College Medicine |
SUPERHELIC MINI-SECTORS AS A TOOL FOR DNS REPAIR, CHANGE AND REPLACEMENT
|
|
US9102936B2
(en)
*
|
2012-06-11 |
2015-08-11 |
Agilent Technologies, Inc. |
Method of adaptor-dimer subtraction using a CRISPR CAS6 protein
|
|
CA2876076A1
(en)
|
2012-06-12 |
2013-12-19 |
Soren WARMING |
Methods and compositions for generating conditional knock-out alleles
|
|
EP2674501A1
(en)
|
2012-06-14 |
2013-12-18 |
Agence nationale de sécurité sanitaire de l'alimentation,de l'environnement et du travail |
Method for detecting and identifying enterohemorrhagic Escherichia coli
|
|
US9688971B2
(en)
|
2012-06-15 |
2017-06-27 |
The Regents Of The University Of California |
Endoribonuclease and methods of use thereof
|
|
CA2877290A1
(en)
|
2012-06-19 |
2013-12-27 |
Daniel F. Voytas |
Gene targeting in plants using dna viruses
|
|
US9267127B2
(en)
|
2012-06-21 |
2016-02-23 |
President And Fellows Of Harvard College |
Evolution of bond-forming enzymes
|
|
JP2015522020A
(ja)
|
2012-06-27 |
2015-08-03 |
ザ・トラスティーズ・オブ・プリンストン・ユニバーシティThe Trustees Of Princeton University |
スプリットインテイン、複合体およびそれらの使用
|
|
WO2014005042A2
(en)
|
2012-06-29 |
2014-01-03 |
Massachusetts Institute Of Technology |
Massively parallel combinatorial genetics
|
|
US9125508B2
(en)
|
2012-06-30 |
2015-09-08 |
Seasons 4, Inc. |
Collapsible tree system
|
|
DK3196301T3
(en)
|
2012-07-11 |
2019-01-14 |
Sangamo Therapeutics Inc |
METHODS AND COMPOSITIONS FOR TREATING MONOGENIC DISEASES
|
|
EP2872154B1
(en)
|
2012-07-11 |
2017-05-31 |
Sangamo BioSciences, Inc. |
Methods and compositions for delivery of biologics
|
|
CN116622704A
(zh)
|
2012-07-25 |
2023-08-22 |
布罗德研究所有限公司 |
可诱导的dna结合蛋白和基因组干扰工具及其应用
|
|
JP6340366B2
(ja)
|
2012-07-31 |
2018-06-06 |
イェダ リサーチ アンド デベロップメント カンパニー リミテッド |
運動ニューロン疾患を診断および処置する方法
|
|
US10058078B2
(en)
|
2012-07-31 |
2018-08-28 |
Recombinetics, Inc. |
Production of FMDV-resistant livestock by allele substitution
|
|
WO2014022702A2
(en)
|
2012-08-03 |
2014-02-06 |
The Regents Of The University Of California |
Methods and compositions for controlling gene expression by rna processing
|
|
CN104704110B
(zh)
|
2012-08-29 |
2018-06-01 |
桑格摩生物科学股份有限公司 |
用于治疗遗传性病状的方法和组合物
|
|
WO2014039513A2
(en)
|
2012-09-04 |
2014-03-13 |
The Trustees Of The University Of Pennsylvania |
Inhibition of diacylglycerol kinase to augment adoptive t cell transfer
|
|
CN109517068B
(zh)
|
2012-09-04 |
2023-07-25 |
斯克利普斯研究院 |
具有靶向结合特异性的嵌合多肽
|
|
RU2663725C2
(ru)
|
2012-09-04 |
2018-08-08 |
Селлектис |
Многоцепочечный химерный антигенный рецептор и его применения
|
|
US20140075593A1
(en)
|
2012-09-07 |
2014-03-13 |
Dow Agrosciences Llc |
Fluorescence activated cell sorting (facs) enrichment to generate plants
|
|
CA2884162C
(en)
|
2012-09-07 |
2020-12-29 |
Dow Agrosciences Llc |
Fad3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
|
|
UA119135C2
(uk)
|
2012-09-07 |
2019-05-10 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб отримання трансгенної рослини
|
|
UA118090C2
(uk)
|
2012-09-07 |
2018-11-26 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив
|
|
WO2014043143A1
(en)
|
2012-09-11 |
2014-03-20 |
Life Technologies Corporation |
Nucleic acid amplification
|
|
GB201216564D0
(en)
|
2012-09-17 |
2012-10-31 |
Univ Edinburgh |
Genetically edited animal
|
|
WO2014047103A2
(en)
|
2012-09-18 |
2014-03-27 |
The Translational Genomics Research Institute |
Isolated genes and transgenic organisms for producing biofuels
|
|
US9181535B2
(en)
|
2012-09-24 |
2015-11-10 |
The Chinese University Of Hong Kong |
Transcription activator-like effector nucleases (TALENs)
|
|
DK2904101T3
(da)
|
2012-10-03 |
2019-08-12 |
Agrivida Inc |
Intein-modificerede proteaser, fremstilling deraf og industrielle anvendelser
|
|
JO3470B1
(ar)
|
2012-10-08 |
2020-07-05 |
Merck Sharp & Dohme |
مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv
|
|
WO2014059173A2
(en)
|
2012-10-10 |
2014-04-17 |
Sangamo Biosciences, Inc. |
T cell modifying compounds and uses thereof
|
|
EP3789405A1
(en)
|
2012-10-12 |
2021-03-10 |
The General Hospital Corporation |
Transcription activator-like effector (tale) - lysine-specific demethylase 1 (lsd1) fusion proteins
|
|
ES2690386T3
(es)
|
2012-10-23 |
2018-11-20 |
Toolgen Incorporated |
Composición para escindir un ADN diana que comprende un ARN guía específico para el ADN diana y el ácido nucleico que codifica la proteína Cas o la propia proteína Cas, y sus usos
|
|
US20140115728A1
(en)
|
2012-10-24 |
2014-04-24 |
A. Joseph Tector |
Double knockout (gt/cmah-ko) pigs, organs and tissues
|
|
WO2014070887A1
(en)
|
2012-10-30 |
2014-05-08 |
Recombinetics, Inc. |
Control of sexual maturation in animals
|
|
MX2015005466A
(es)
|
2012-10-31 |
2015-07-23 |
Two Blades Foundation |
Identificacion de un gen resistente a xantomonas euvesicatoria del pimiento (capsicum annuum) y metodo para generar plantas con resistencia.
|
|
US20150291967A1
(en)
|
2012-10-31 |
2015-10-15 |
Luc Mathis |
Coupling herbicide resistance with targeted insertion of transgenes in plants
|
|
WO2014071235A1
(en)
|
2012-11-01 |
2014-05-08 |
Massachusetts Institute Of Technology |
Genetic device for the controlled destruction of dna
|
|
AU2013337651B2
(en)
|
2012-11-01 |
2018-12-13 |
Factor Bioscience Inc. |
Methods and products for expressing proteins in cells
|
|
US20140127752A1
(en)
|
2012-11-07 |
2014-05-08 |
Zhaohui Zhou |
Method, composition, and reagent kit for targeted genomic enrichment
|
|
CA2890824A1
(en)
|
2012-11-09 |
2014-05-15 |
Marco Archetti |
Diffusible factors and cancer cells
|
|
US20140140969A1
(en)
|
2012-11-20 |
2014-05-22 |
Sangamo Biosciences, Inc. |
Methods and compositions for muscular dystrophies
|
|
WO2014081730A1
(en)
|
2012-11-20 |
2014-05-30 |
Cold Spring Harbor Laboratory |
Mutations in solanaceae plants that modulate shoot architecture and enhance yield-related phenotypes
|
|
MX2015006220A
(es)
|
2012-11-20 |
2016-07-20 |
Simplot Co J R |
Insercion de adn de tranferencia mediada por efectores tipo activadores de la transcripción (tal).
|
|
CN104955943B
(zh)
|
2012-11-27 |
2018-09-25 |
儿童医疗中心有限公司 |
用于胎儿血红蛋白再诱导的靶向bcl11a远端调控元件
|
|
WO2014085261A1
(en)
|
2012-11-29 |
2014-06-05 |
North Carolina State University |
Synthetic pathway for biological carbon dioxide sequestration
|
|
WO2014085830A2
(en)
|
2012-11-30 |
2014-06-05 |
The Parkinson's Institute |
Screening assays for therapeutics for parkinson's disease
|
|
DK2925866T3
(en)
|
2012-11-30 |
2018-10-29 |
Univ Aarhus |
CIRCULAR RNA FOR INHIBITING MICRO-RNA
|
|
WO2014089212A1
(en)
|
2012-12-05 |
2014-06-12 |
Sangamo Biosciences, Inc. |
Methods and compositions for regulation of metabolic disorders
|
|
PT3363902T
(pt)
|
2012-12-06 |
2019-12-19 |
Sigma Aldrich Co Llc |
Modificação e regulação de genoma baseadas em crispr
|
|
WO2014089513A1
(en)
|
2012-12-06 |
2014-06-12 |
Synthetic Genomics, Inc. |
Autonomous replication sequences and episomal dna molecules
|
|
AU2013355001B2
(en)
|
2012-12-06 |
2017-10-26 |
Synthetic Genomics, Inc. |
Algal mutants having a locked-in high light acclimated phenotype
|
|
US10272163B2
(en)
|
2012-12-07 |
2019-04-30 |
The Regents Of The University Of California |
Factor VIII mutation repair and tolerance induction
|
|
WO2014089348A1
(en)
|
2012-12-07 |
2014-06-12 |
Synthetic Genomics, Inc. |
Nannochloropsis spliced leader sequences and uses therefor
|
|
WO2014093479A1
(en)
|
2012-12-11 |
2014-06-19 |
Montana State University |
Crispr (clustered regularly interspaced short palindromic repeats) rna-guided control of gene regulation
|
|
WO2014093694A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes
|
|
WO2014093701A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
EP3702463B1
(en)
|
2012-12-12 |
2025-03-19 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions for sequence manipulation
|
|
SG10201912328UA
(en)
|
2012-12-12 |
2020-02-27 |
Broad Inst Inc |
Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Therapeutic Applications
|
|
US8993233B2
(en)
|
2012-12-12 |
2015-03-31 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
WO2014093709A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
EP2840140B2
(en)
|
2012-12-12 |
2023-02-22 |
The Broad Institute, Inc. |
Crispr-Cas based method for mutation of prokaryotic cells
|
|
MX380562B
(es)
|
2012-12-12 |
2025-03-12 |
Broad Inst Inc |
Modificaciones de sistemas, métodos y composiciones guía optimizadas para la manipulación de secuencias.
|
|
JP6552965B2
(ja)
|
2012-12-12 |
2019-07-31 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
配列操作のための改善された系、方法および酵素組成物のエンジニアリングおよび最適化
|
|
AR093979A1
(es)
|
2012-12-13 |
2015-07-01 |
Dow Agrosciences Llc |
Metodos de deteccion de adn para actividad de nucleasa especifica de sitio
|
|
AU2013358998B2
(en)
|
2012-12-13 |
2019-04-18 |
Massachusetts Institute Of Technology |
Recombinase-based logic and memory systems
|
|
BR102013032200A2
(pt)
|
2012-12-13 |
2015-11-24 |
Dow Agrosciences Llc |
direcionamento preciso de um gene para um locus específico em milho
|
|
WO2014099744A1
(en)
|
2012-12-17 |
2014-06-26 |
President And Fellows Of Harvard College |
Rna-guided human genome engineering
|
|
PL2934097T3
(pl)
|
2012-12-21 |
2018-11-30 |
Cellectis |
Ziemniaki o ograniczonej słodkości indukowanej chłodem
|
|
TR201900252T4
(tr)
|
2012-12-27 |
2019-02-21 |
Keygene Nv |
Bir Bitkide Genetik Bağın Ortadan Kaldırılmasına Yönelik Yöntem
|
|
EP2943579B1
(en)
|
2013-01-10 |
2018-09-12 |
Dharmacon, Inc. |
Libraries and methods for generating molecules
|
|
CN105142396A
(zh)
|
2013-01-14 |
2015-12-09 |
重组股份有限公司 |
缺角家畜
|
|
WO2014113493A1
(en)
|
2013-01-16 |
2014-07-24 |
Emory University |
Cas9-nucleic acid complexes and uses related thereto
|
|
CN103233028B
(zh)
|
2013-01-25 |
2015-05-13 |
南京徇齐生物技术有限公司 |
一种无物种限制无生物安全性问题的真核生物基因打靶方法及螺旋结构dna序列
|
|
WO2014123967A2
(en)
|
2013-02-05 |
2014-08-14 |
University Of Georgia Research Foundation, Inc. |
Cell lines for virus production and methods of use
|
|
WO2014124226A1
(en)
|
2013-02-07 |
2014-08-14 |
The Rockefeller University |
Sequence specific antimicrobials
|
|
WO2014127287A1
(en)
|
2013-02-14 |
2014-08-21 |
Massachusetts Institute Of Technology |
Method for in vivo tergated mutagenesis
|
|
US11466306B2
(en)
|
2013-02-14 |
2022-10-11 |
Osaka University |
Method for isolating specific genomic regions with use of molecule capable of specifically binding to endogenous DNA sequence
|
|
ES2904803T3
(es)
|
2013-02-20 |
2022-04-06 |
Regeneron Pharma |
Modificación genética de ratas
|
|
US20150353885A1
(en)
|
2013-02-21 |
2015-12-10 |
Cellectis |
Method to counter-select cells or organisms by linking loci to nuclease components
|
|
ES2522765B2
(es)
|
2013-02-22 |
2015-03-18 |
Universidad De Alicante |
Método para dectectar inserciones de espaciadores en estructuras CRISPR
|
|
US10227610B2
(en)
|
2013-02-25 |
2019-03-12 |
Sangamo Therapeutics, Inc. |
Methods and compositions for enhancing nuclease-mediated gene disruption
|
|
JP2016507244A
(ja)
|
2013-02-27 |
2016-03-10 |
ヘルムホルツ・ツェントルム・ミュンヒェン・ドイチェス・フォルシュンクスツェントルム・フューア・ゲズントハイト・ウント・ウムベルト(ゲーエムベーハー)Helmholtz Zentrum MuenchenDeutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH) |
Cas9ヌクレアーゼによる卵母細胞における遺伝子編集
|
|
WO2014138379A1
(en)
|
2013-03-06 |
2014-09-12 |
The Johns Hopkins University |
The telomerator-a tool for chromosome engineering
|
|
WO2014143381A1
(en)
|
2013-03-09 |
2014-09-18 |
Agilent Technologies, Inc. |
Methods of in vivo engineering of large sequences using multiple crispr/cas selections of recombineering events
|
|
US20150037304A1
(en)
|
2013-03-12 |
2015-02-05 |
Sangamo Biosciences, Inc. |
Methods and compositions for modification of hla
|
|
RU2694686C2
(ru)
|
2013-03-12 |
2019-07-16 |
Е.И.Дюпон Де Немур Энд Компани |
Способы идентификации вариантных сайтов распознавания для редкощепящих сконструированных средств для индукции двунитевого разрыва, и композиции с ними, и их применения
|
|
US9777262B2
(en)
|
2013-03-13 |
2017-10-03 |
President And Fellows Of Harvard College |
Mutants of Cre recombinase
|
|
RU2662932C2
(ru)
|
2013-03-14 |
2018-07-31 |
Карибо Биосайенсиз, Инк. |
Композиции и способы с участием нуклеиновых кислот, нацеленных на нуклеиновые кислоты
|
|
US20160184458A1
(en)
|
2013-03-14 |
2016-06-30 |
Shire Human Genetic Therapies, Inc. |
Mrna therapeutic compositions and use to treat diseases and disorders
|
|
US20160138027A1
(en)
|
2013-03-14 |
2016-05-19 |
The Board Of Trustees Of The Leland Stanford Junior University |
Treatment of diseases and conditions associated with dysregulation of mammalian target of rapamycin complex 1 (mtorc1)
|
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
WO2014144094A1
(en)
|
2013-03-15 |
2014-09-18 |
J.R. Simplot Company |
Tal-mediated transfer dna insertion
|
|
EP3988667A1
(en)
|
2013-03-15 |
2022-04-27 |
The General Hospital Corporation |
Using truncated guide rnas (tru-grnas) to increase specificity for rna-guided genome editing
|
|
US20140273230A1
(en)
|
2013-03-15 |
2014-09-18 |
Sigma-Aldrich Co., Llc |
Crispr-based genome modification and regulation
|
|
WO2014145736A2
(en)
|
2013-03-15 |
2014-09-18 |
Transposagen Biopharmaceuticals, Inc. |
Reproducible method for testis-mediated genetic modification (tgm) and sperm-mediated genetic modification (sgm)
|
|
RS63427B1
(sr)
|
2013-03-15 |
2022-08-31 |
Cibus Us Llc |
Postupci i kompozicije za povećanje efikasnosti modifikacije ciljnog gena korišćenjem genske reparacije posredovane oligonukleotidom
|
|
AU2014227831B2
(en)
|
2013-03-15 |
2020-01-30 |
Regents Of The University Of Minnesota |
Engineering plant genomes using CRISPR/Cas systems
|
|
WO2014204578A1
(en)
|
2013-06-21 |
2014-12-24 |
The General Hospital Corporation |
Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing
|
|
US20140349400A1
(en)
|
2013-03-15 |
2014-11-27 |
Massachusetts Institute Of Technology |
Programmable Modification of DNA
|
|
US11332719B2
(en)
|
2013-03-15 |
2022-05-17 |
The Broad Institute, Inc. |
Recombinant virus and preparations thereof
|
|
US9234213B2
(en)
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
|
US9937207B2
(en)
|
2013-03-21 |
2018-04-10 |
Sangamo Therapeutics, Inc. |
Targeted disruption of T cell receptor genes using talens
|
|
BR112015025006A2
(pt)
|
2013-04-02 |
2017-10-10 |
Bayer Cropscience Nv |
engenharia genômica alvejada em eucariontes
|
|
EP3789487A1
(en)
|
2013-04-03 |
2021-03-10 |
Memorial Sloan Kettering Cancer Center |
Effective generation of tumor-targeted t-cells derived from pluripotent stem cells
|
|
CA2908253C
(en)
|
2013-04-04 |
2024-01-09 |
Trustees Of Dartmouth College |
Compositions and methods for in vivo excision of hiv-1 proviral dna
|
|
WO2014165825A2
(en)
|
2013-04-04 |
2014-10-09 |
President And Fellows Of Harvard College |
Therapeutic uses of genome editing with crispr/cas systems
|
|
EP3679785A3
(en)
|
2013-04-05 |
2020-09-16 |
Dow AgroSciences LLC |
Methods and compositions for integration of an exogenous sequence within the genome of plants
|
|
US20150056629A1
(en)
|
2013-04-14 |
2015-02-26 |
Katriona Guthrie-Honea |
Compositions, systems, and methods for detecting a DNA sequence
|
|
HUE056903T2
(hu)
|
2013-04-16 |
2022-04-28 |
Regeneron Pharma |
Patkány genom célzott módosítása
|
|
WO2014172458A1
(en)
|
2013-04-16 |
2014-10-23 |
University Of Washington Through Its Center For Commercialization |
Activating an alternative pathway for homology-directed repair to stimulate targeted gene correction and genome engineering
|
|
US20160186208A1
(en)
|
2013-04-16 |
2016-06-30 |
Whitehead Institute For Biomedical Research |
Methods of Mutating, Modifying or Modulating Nucleic Acid in a Cell or Nonhuman Mammal
|
|
EP2796558A1
(en)
|
2013-04-23 |
2014-10-29 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Improved gene targeting and nucleic acid carrier molecule, in particular for use in plants
|
|
CN103224947B
(zh)
|
2013-04-28 |
2015-06-10 |
陕西师范大学 |
一种基因打靶系统
|
|
AU2014262867B2
(en)
|
2013-05-10 |
2019-12-05 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
|
AU2014262474B2
(en)
|
2013-05-10 |
2019-10-31 |
Whitehead Institute For Biomedical Research |
In vitro production of red blood cells with sortaggable proteins
|
|
MX2015015638A
(es)
|
2013-05-13 |
2016-10-28 |
Cellectis |
Metodos para diseñar celulas t altamente activas para inmunoterapia.
|
|
MX374681B
(es)
|
2013-05-13 |
2025-03-06 |
Cellectis |
Receptor quimérico de antígeno específico para cd19 y sus usos.
|
|
WO2014186585A2
(en)
|
2013-05-15 |
2014-11-20 |
Sangamo Biosciences, Inc. |
Methods and compositions for treatment of a genetic condition
|
|
WO2014186686A2
(en)
|
2013-05-17 |
2014-11-20 |
Two Blades Foundation |
Targeted mutagenesis and genome engineering in plants using rna-guided cas nucleases
|
|
WO2014190181A1
(en)
|
2013-05-22 |
2014-11-27 |
Northwestern University |
Rna-directed dna cleavage and gene editing by cas9 enzyme from neisseria meningitidis
|
|
US11414695B2
(en)
|
2013-05-29 |
2022-08-16 |
Agilent Technologies, Inc. |
Nucleic acid enrichment using Cas9
|
|
US11685935B2
(en)
|
2013-05-29 |
2023-06-27 |
Cellectis |
Compact scaffold of Cas9 in the type II CRISPR system
|
|
ES2670531T3
(es)
|
2013-05-29 |
2018-05-30 |
Cellectis S.A. |
Un método para producir una escisión de ADN precisa utilizando la actividad nickasa de Cas9
|
|
AU2014273490B2
(en)
|
2013-05-29 |
2019-05-09 |
Cellectis |
Methods for engineering T cells for immunotherapy by using RNA-guided Cas nuclease system
|
|
WO2014194190A1
(en)
|
2013-05-30 |
2014-12-04 |
The Penn State Research Foundation |
Gene targeting and genetic modification of plants via rna-guided genome editing
|
|
EP3004149B1
(en)
|
2013-05-31 |
2018-12-19 |
Cellectis S.A. |
A laglidadg homing endonuclease cleaving the c-c chemokine receptor type-5 (ccr5) gene and uses thereof
|
|
JP6450371B2
(ja)
|
2013-05-31 |
2019-01-09 |
セレクティスCellectis |
T細胞受容体α遺伝子を開裂するLAGLIDADGホーミングエンドヌクレアーゼおよびその用途
|
|
US20140359796A1
(en)
|
2013-05-31 |
2014-12-04 |
Recombinetics, Inc. |
Genetically sterile animals
|
|
IL302205B2
(en)
|
2013-06-04 |
2025-08-01 |
Harvard College |
Rna-guided transcriptional regulation
|
|
US9267135B2
(en)
|
2013-06-04 |
2016-02-23 |
President And Fellows Of Harvard College |
RNA-guided transcriptional regulation
|
|
CN105658805B
(zh)
|
2013-06-05 |
2021-12-31 |
杜克大学 |
Rna指导的基因编辑和基因调节
|
|
US9982277B2
(en)
|
2013-06-11 |
2018-05-29 |
The Regents Of The University Of California |
Methods and compositions for target DNA modification
|
|
EP3663405B8
(en)
|
2013-06-11 |
2024-10-30 |
Takara Bio USA, Inc. |
Protein enriched microvesicles and methods of making and using the same
|
|
US20150315252A1
(en)
|
2013-06-11 |
2015-11-05 |
Clontech Laboratories, Inc. |
Protein enriched microvesicles and methods of making and using the same
|
|
CA2913404C
(en)
|
2013-06-14 |
2023-10-03 |
Cellectis |
Methods for non-transgenic genome editing in plants
|
|
SG11201510286QA
(en)
|
2013-06-17 |
2016-01-28 |
Broad Inst Inc |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components
|
|
WO2014204723A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Oncogenic models based on delivery and use of the crispr-cas systems, vectors and compositions
|
|
JP6738729B2
(ja)
|
2013-06-17 |
2020-08-12 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
分裂終了細胞の疾患および障害をターゲティングおよびモデリングするための系、方法および組成物の送達、エンジニアリングおよび最適化
|
|
KR20160030187A
(ko)
|
2013-06-17 |
2016-03-16 |
더 브로드 인스티튜트, 인코퍼레이티드 |
간의 표적화 및 치료를 위한 CRISPRCas 시스템, 벡터 및 조성물의 전달 및 용도
|
|
WO2014204724A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
|
EP3725885A1
(en)
|
2013-06-17 |
2020-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
EP4245853A3
(en)
|
2013-06-17 |
2023-10-18 |
The Broad Institute, Inc. |
Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
|
|
WO2014205192A2
(en)
|
2013-06-19 |
2014-12-24 |
Sigma-Aldrich Co. Llc |
Targeted integration
|
|
JP2016523093A
(ja)
|
2013-06-25 |
2016-08-08 |
セレクティスCellectis |
バイオ燃料生産のための改変された珪藻
|
|
WO2015002780A1
(en)
|
2013-07-01 |
2015-01-08 |
The Board Of Regents Of The University Of Texas System |
Transcription activator-like effector (tale) libraries and methods of synthesis and use
|
|
CN116042726A
(zh)
|
2013-07-09 |
2023-05-02 |
哈佛大学校长及研究员协会 |
多重rna向导的基因组工程
|
|
WO2015006498A2
(en)
|
2013-07-09 |
2015-01-15 |
President And Fellows Of Harvard College |
Therapeutic uses of genome editing with crispr/cas systems
|
|
JP2016523552A
(ja)
|
2013-07-10 |
2016-08-12 |
ノバルティス アーゲー |
多重プロテアーゼ欠損糸状菌細胞及びその使用方法
|
|
WO2015006294A2
(en)
|
2013-07-10 |
2015-01-15 |
President And Fellows Of Harvard College |
Orthogonal cas9 proteins for rna-guided gene regulation and editing
|
|
KR102297747B1
(ko)
|
2013-07-10 |
2021-09-06 |
에프스톡 엘엘씨 |
Mrap2 녹아웃
|
|
SI3019619T1
(sl)
|
2013-07-11 |
2021-12-31 |
Modernatx, Inc. |
Sestave, ki zajemajo sintetične polinukleotide, ki kodirajo proteine, pozvezane s crispr, in sintetične sgrna, ter metode uporabe
|
|
CN106222197A
(zh)
|
2013-07-16 |
2016-12-14 |
中国科学院上海生命科学研究院 |
植物基因组定点修饰方法
|
|
EP3022304B1
(en)
|
2013-07-19 |
2018-12-26 |
Larix Biosciences LLC |
Methods and compositions for producing double allele knock outs
|
|
GB201313235D0
(en)
|
2013-07-24 |
2013-09-04 |
Univ Edinburgh |
Antiviral Compositions Methods and Animals
|
|
US11306328B2
(en)
|
2013-07-26 |
2022-04-19 |
President And Fellows Of Harvard College |
Genome engineering
|
|
CN103388006B
(zh)
|
2013-07-26 |
2015-10-28 |
华东师范大学 |
一种基因定点突变的构建方法
|
|
US10421957B2
(en)
|
2013-07-29 |
2019-09-24 |
Agilent Technologies, Inc. |
DNA assembly using an RNA-programmable nickase
|
|
WO2015017866A1
(en)
|
2013-08-02 |
2015-02-05 |
Enevolv, Inc. |
Processes and host cells for genome, pathway, and biomolecular engineering
|
|
ITTO20130669A1
(it)
|
2013-08-05 |
2015-02-06 |
Consiglio Nazionale Ricerche |
Vettore adeno-associato ricombinante muscolo-specifico e suo impiego nel trattamento di patologie muscolari
|
|
WO2015021426A1
(en)
|
2013-08-09 |
2015-02-12 |
Sage Labs, Inc. |
A crispr/cas system-based novel fusion protein and its application in genome editing
|
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
|
WO2015021990A1
(en)
|
2013-08-16 |
2015-02-19 |
University Of Copenhagen |
Rna probing method and reagents
|
|
WO2015024017A2
(en)
|
2013-08-16 |
2015-02-19 |
President And Fellows Of Harvard College |
Rna polymerase, methods of purification and methods of use
|
|
DK3036326T3
(en)
|
2013-08-20 |
2018-01-08 |
Vib Vzw |
INHIBITION OF A LNCRNA FOR TREATMENT OF MELANOMES
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
AU2014308896A1
(en)
|
2013-08-22 |
2016-03-10 |
E. I. Du Pont De Nemours And Company |
Plant genome modification using guide RNA/Cas endonuclease systems and methods of use
|
|
EP3988654A1
(en)
|
2013-08-28 |
2022-04-27 |
Sangamo Therapeutics, Inc. |
Compositions for linking dna-binding domains and cleavage domains
|
|
GB201315321D0
(en)
|
2013-08-28 |
2013-10-09 |
Koninklijke Nederlandse Akademie Van Wetenschappen |
Transduction Buffer
|
|
EA037850B1
(ru)
|
2013-08-29 |
2021-05-27 |
Тэмпл Юниверсити Оф Зе Коммонвэлс Систем Оф Хайе Эдьюкейшн |
Способы и композиции для рнк-направленного лечения вич-инфекции
|
|
JP6535333B2
(ja)
|
2013-09-04 |
2019-06-26 |
シーエスアイアール |
遺伝子発現をサイレンシングする遺伝子制御エレメントを標的とする部位特異的ヌクレアーゼ単一細胞アッセイ
|
|
AU2014315335B2
(en)
|
2013-09-04 |
2017-08-24 |
Corteva Agriscience Llc |
Rapid targeting analysis in crops for determining donor insertion
|
|
WO2015032494A2
(de)
|
2013-09-04 |
2015-03-12 |
Kws Saat Ag |
Helminthosporium turcicum-resistente pflanze
|
|
WO2015034872A2
(en)
|
2013-09-05 |
2015-03-12 |
Massachusetts Institute Of Technology |
Tuning microbial populations with programmable nucleases
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
US9737604B2
(en)
|
2013-09-06 |
2017-08-22 |
President And Fellows Of Harvard College |
Use of cationic lipids to deliver CAS9
|
|
US9228207B2
(en)
|
2013-09-06 |
2016-01-05 |
President And Fellows Of Harvard College |
Switchable gRNAs comprising aptamers
|
|
EP3988649B1
(en)
|
2013-09-18 |
2024-11-27 |
Kymab Limited |
Methods, cells and organisms
|
|
WO2015040075A1
(en)
|
2013-09-18 |
2015-03-26 |
Genome Research Limited |
Genomic screening methods using rna-guided endonucleases
|
|
JP6595459B2
(ja)
|
2013-09-23 |
2019-10-23 |
レンセラール ポリテクニック インスティチュート |
種々の細胞集団におけるナノ粒子媒介遺伝子送達、ゲノム編集およびリガンド標的化修飾
|
|
US20160237455A1
(en)
|
2013-09-27 |
2016-08-18 |
Editas Medicine, Inc. |
Crispr-related methods and compositions
|
|
US10822606B2
(en)
|
2013-09-27 |
2020-11-03 |
The Regents Of The University Of California |
Optimized small guide RNAs and methods of use
|
|
US20160237451A1
(en)
|
2013-09-30 |
2016-08-18 |
Regents Of The University Of Minnesota |
Conferring resistance to geminiviruses in plants using crispr/cas systems
|
|
CA2925050A1
(en)
|
2013-09-30 |
2015-04-02 |
The Regents Of The University Of California |
Identification of cxcr8, a novel chemokine receptor
|
|
EP3052110A4
(en)
|
2013-10-02 |
2017-07-12 |
Northeastern University |
Methods and compositions for generation of developmentally-incompetent eggs in recipients of nuclear genetic transfer
|
|
JP5774657B2
(ja)
|
2013-10-04 |
2015-09-09 |
国立大学法人京都大学 |
エレクトロポレーションを利用した哺乳類の遺伝子改変方法
|
|
WO2015054315A1
(en)
|
2013-10-07 |
2015-04-16 |
Northeastern University |
Methods and compositions for ex vivo generation of developmentally competent eggs from germ line cells using autologous cell systems
|
|
DE102013111099B4
(de)
|
2013-10-08 |
2023-11-30 |
Eberhard Karls Universität Tübingen Medizinische Fakultät |
Permanente Genkorrektur mittels nukleotidmodifizierter messenger RNA
|
|
US20150098954A1
(en)
|
2013-10-08 |
2015-04-09 |
Elwha Llc |
Compositions and Methods Related to CRISPR Targeting
|
|
WO2015052231A2
(en)
|
2013-10-08 |
2015-04-16 |
Technical University Of Denmark |
Multiplex editing system
|
|
AU2014333776B2
(en)
|
2013-10-11 |
2021-01-28 |
Cellectis |
Methods and kits for detecting nucleic acid sequences of interest using DNA-binding protein domain
|
|
WO2015057671A1
(en)
|
2013-10-14 |
2015-04-23 |
The Broad Institute, Inc. |
Artificial transcription factors comprising a sliding domain and uses thereof
|
|
CA2926698C
(en)
|
2013-10-15 |
2021-06-22 |
The California Institute For Biomedical Research |
Chimeric antigen receptor t cell switches and uses thereof
|
|
WO2015057834A1
(en)
|
2013-10-15 |
2015-04-23 |
The California Institute For Biomedical Research |
Peptidic chimeric antigen receptor t cell switches and uses thereof
|
|
AU2014337248B2
(en)
|
2013-10-17 |
2020-09-24 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
|
WO2015057976A1
(en)
|
2013-10-17 |
2015-04-23 |
Sangamo Biosciences, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
|
|
JP7083595B2
(ja)
|
2013-10-25 |
2022-06-13 |
セレクティス |
高反復モチーフを備えたdna配列を効率的かつ特異的に標的とするレアカットエンドヌクレアーゼの設計
|
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
|
US10584358B2
(en)
|
2013-10-30 |
2020-03-10 |
North Carolina State University |
Compositions and methods related to a type-II CRISPR-Cas system in Lactobacillus buchneri
|
|
BR102014027438B1
(pt)
|
2013-11-04 |
2022-09-27 |
Dow Agrosciences Llc |
Molécula de ácido nucleico recombinante e método de produção de uma célula vegetal transgênica
|
|
CN105980395A
(zh)
|
2013-11-04 |
2016-09-28 |
美国陶氏益农公司 |
最优大豆座位
|
|
AU2014341934B2
(en)
|
2013-11-04 |
2017-12-07 |
Corteva Agriscience Llc |
Optimal soybean loci
|
|
CA2926534A1
(en)
|
2013-11-04 |
2015-05-07 |
Dow Agrosciences Llc |
A universal donor system for gene targeting
|
|
AP2016009227A0
(en)
|
2013-11-04 |
2016-05-31 |
Dow Agrosciences Llc |
Optimal maize loci
|
|
US10752906B2
(en)
|
2013-11-05 |
2020-08-25 |
President And Fellows Of Harvard College |
Precise microbiota engineering at the cellular level
|
|
EP3066201B1
(en)
|
2013-11-07 |
2018-03-07 |
Editas Medicine, Inc. |
Crispr-related methods and compositions with governing grnas
|
|
WO2015077058A2
(en)
|
2013-11-08 |
2015-05-28 |
The Broad Institute, Inc. |
Compositions and methods for selecting a treatment for b-cell neoplasias
|
|
BR112016010175A2
(pt)
|
2013-11-11 |
2017-10-03 |
Sangamo Biosciences Inc |
Repressor genético, seus usos, e composição farmacêutica
|
|
WO2015070193A1
(en)
|
2013-11-11 |
2015-05-14 |
Liu Oliver |
Compositions and methods for targeted gene disruption in prokaryotes
|
|
LT3068881T
(lt)
|
2013-11-13 |
2019-08-12 |
Children`S Medical Center Corporation |
Geno raiškos reguliavimas, tarpininkaujant nukleazei
|
|
US9951353B2
(en)
|
2013-11-15 |
2018-04-24 |
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services |
Engineering neural stem cells using homologous recombination
|
|
WO2015071474A2
(en)
|
2013-11-18 |
2015-05-21 |
Crispr Therapeutics Ag |
Crispr-cas system materials and methods
|
|
AU2014348291A1
(en)
|
2013-11-18 |
2016-05-19 |
Yale University |
Compositions and methods of using transposons
|
|
WO2015075056A1
(en)
|
2013-11-19 |
2015-05-28 |
Thermo Fisher Scientific Baltics Uab |
Programmable enzymes for isolation of specific dna fragments
|
|
US9074199B1
(en)
|
2013-11-19 |
2015-07-07 |
President And Fellows Of Harvard College |
Mutant Cas9 proteins
|
|
US10787684B2
(en)
|
2013-11-19 |
2020-09-29 |
President And Fellows Of Harvard College |
Large gene excision and insertion
|
|
CN105960413B
(zh)
|
2013-11-20 |
2020-03-27 |
泰莱托恩基金会 |
人工dna-结合蛋白及其用途
|
|
US10813951B2
(en)
|
2013-11-22 |
2020-10-27 |
Cellectis |
Method of engineering chemotherapy drug resistant T-cells for immunotherapy
|
|
CA2930973C
(en)
|
2013-11-22 |
2024-07-02 |
Mina Therapeutics Ltd |
C/ebp alpha short activating rna compositions and methods of use
|
|
JP2016539117A
(ja)
|
2013-11-22 |
2016-12-15 |
セレクティスCellectis |
平均化された効力を持つ同種異系t細胞のバッチを生成するための方法
|
|
CN103642836A
(zh)
|
2013-11-26 |
2014-03-19 |
苏州同善生物科技有限公司 |
一种基于crispr基因敲除技术建立脆性x综合症灵长类动物模型的方法
|
|
CN103614415A
(zh)
|
2013-11-27 |
2014-03-05 |
苏州同善生物科技有限公司 |
一种基于crispr基因敲除技术建立肥胖症大鼠动物模型的方法
|
|
WO2015079057A2
(en)
|
2013-11-28 |
2015-06-04 |
Haplogen Genomics Gmbh |
Somatic haploid human cell line
|
|
EP3080274B1
(en)
|
2013-12-09 |
2020-06-03 |
Sangamo Therapeutics, Inc. |
Methods and compositions for genome engineering
|
|
MX388127B
(es)
|
2013-12-11 |
2025-03-19 |
Regeneron Pharma |
Metodos y composiciones para la modificacion dirigida de un genoma.
|
|
KR20160089530A
(ko)
|
2013-12-12 |
2016-07-27 |
더 브로드 인스티튜트, 인코퍼레이티드 |
Hbv 및 바이러스 질병 및 질환을 위한 crisprcas 시스템 및 조성물의 전달,용도 및 치료적 적용
|
|
JP7103750B2
(ja)
|
2013-12-12 |
2022-07-20 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
ゲノム編集のためのCRISPR-Cas系及び組成物の送達、使用及び治療適用
|
|
WO2015089419A2
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components
|
|
JP6793547B2
(ja)
|
2013-12-12 |
2020-12-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
最適化機能CRISPR−Cas系による配列操作のための系、方法および組成物
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
EP3835419A1
(en)
|
2013-12-12 |
2021-06-16 |
The Regents of The University of California |
Methods and compositions for modifying a single stranded target nucleic acid
|
|
EP3080259B1
(en)
|
2013-12-12 |
2023-02-01 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
KR20160097327A
(ko)
|
2013-12-12 |
2016-08-17 |
더 브로드 인스티튜트, 인코퍼레이티드 |
유전자 산물, 구조 정보 및 유도성 모듈형 cas 효소의 발현의 변경을 위한 crispr-cas 시스템 및 방법
|
|
EP3080258A1
(en)
|
2013-12-12 |
2016-10-19 |
The Broad Institute, Inc. |
Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders
|
|
US9068179B1
(en)
|
2013-12-12 |
2015-06-30 |
President And Fellows Of Harvard College |
Methods for correcting presenilin point mutations
|
|
WO2015086798A2
(en)
|
2013-12-13 |
2015-06-18 |
Cellectis |
New method of selection of algal-transformed cells using nuclease
|
|
AU2014363476A1
(en)
|
2013-12-13 |
2016-06-23 |
Cellectis |
Cas9 nuclease platform for microalgae genome engineering
|
|
US20150191744A1
(en)
|
2013-12-17 |
2015-07-09 |
University Of Massachusetts |
Cas9 effector-mediated regulation of transcription, differentiation and gene editing/labeling
|
|
CN106029886B
(zh)
|
2013-12-19 |
2021-02-05 |
阿迈瑞斯公司 |
基因组整合的方法
|
|
CN106103706B
(zh)
|
2013-12-26 |
2021-08-24 |
通用医疗公司 |
多重引导rna
|
|
ES2818625T3
(es)
|
2013-12-30 |
2021-04-13 |
Univ Pittsburgh Commonwealth Sys Higher Education |
Genes de fusión asociados con el cáncer de próstata progresivo
|
|
WO2015103153A1
(en)
|
2013-12-31 |
2015-07-09 |
The Regents Of The University Of California |
Cas9 crystals and methods of use thereof
|
|
CN103668472B
(zh)
|
2013-12-31 |
2014-12-24 |
北京大学 |
利用CRISPR/Cas9系统构建真核基因敲除文库的方法
|
|
WO2015105928A1
(en)
|
2014-01-08 |
2015-07-16 |
President And Fellows Of Harvard College |
Rna-guided gene drives
|
|
WO2015108993A1
(en)
|
2014-01-14 |
2015-07-23 |
Lam Therapeutics, Inc. |
Mutagenesis methods
|
|
US10774338B2
(en)
|
2014-01-16 |
2020-09-15 |
The Regents Of The University Of California |
Generation of heritable chimeric plant traits
|
|
WO2015134121A2
(en)
|
2014-01-20 |
2015-09-11 |
President And Fellows Of Harvard College |
Negative selection and stringency modulation in continuous evolution systems
|
|
CN106164272B
(zh)
|
2014-01-21 |
2020-12-29 |
中国科学院遗传与发育生物学研究所 |
修饰的植物
|
|
GB201400962D0
(en)
|
2014-01-21 |
2014-03-05 |
Kloehn Peter C |
Screening for target-specific affinity binders using RNA interference
|
|
JP6479024B2
(ja)
|
2014-01-24 |
2019-03-06 |
ザ チルドレンズ メディカル センター コーポレーション |
抗体親和性の最適化のための高スループットマウスモデル
|
|
WO2015112896A2
(en)
|
2014-01-24 |
2015-07-30 |
North Carolina State University |
Methods and compositions for sequences guiding cas9 targeting
|
|
US10354746B2
(en)
|
2014-01-27 |
2019-07-16 |
Georgia Tech Research Corporation |
Methods and systems for identifying CRISPR/Cas off-target sites
|
|
CN104805078A
(zh)
|
2014-01-28 |
2015-07-29 |
北京大学 |
用于高效基因组编辑的rna分子的设计、合成及其应用
|
|
WO2015116686A1
(en)
|
2014-01-29 |
2015-08-06 |
Agilent Technologies, Inc. |
Cas9-based isothermal method of detection of specific dna sequence
|
|
WO2015116969A2
(en)
|
2014-01-30 |
2015-08-06 |
The Board Of Trustees Of The University Of Arkansas |
Method, vectors, cells, seeds and kits for stacking genes into a single genomic site
|
|
WO2015117041A1
(en)
|
2014-01-30 |
2015-08-06 |
Nair Ramesh B |
Gene modification-mediated methods and compositions for generating dominant traits in eukaryotic systems
|
|
BR112016017736A2
(pt)
|
2014-01-31 |
2017-10-10 |
Factor Bioscience Inc |
métodos e produtos para produção e distribuição de ácido nucleico
|
|
GB201401707D0
(en)
|
2014-01-31 |
2014-03-19 |
Sec Dep For Health The |
Adeno-associated viral vectors
|
|
WO2015115903A1
(en)
|
2014-02-03 |
2015-08-06 |
Academisch Ziekenhuis Leiden H.O.D.N. Lumc |
Site-specific dna break-induced genome editing using engineered nucleases
|
|
US10072066B2
(en)
|
2014-02-03 |
2018-09-11 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treatment of a beta thalessemia
|
|
PL3102722T3
(pl)
|
2014-02-04 |
2021-03-08 |
Jumpcode Genomics, Inc. |
Frakcjonowanie genomu
|
|
AU2015214141B2
(en)
|
2014-02-07 |
2020-07-30 |
Katholieke Universiteit Leuven, K.U.Leuven R&D |
Inhibition of NEAT1 for treatment of solid tumors
|
|
ES2802984T3
(es)
|
2014-02-11 |
2021-01-22 |
Univ Colorado Regents |
Ingeniería del genoma multiplex mediante CRISPR
|
|
CN106232814B
(zh)
|
2014-02-13 |
2021-05-11 |
宝生物工程(美国)有限公司 |
从核酸的初始集合中耗尽靶分子的方法、以及用于实践其的组合物和试剂盒
|
|
EP3105317B1
(en)
|
2014-02-14 |
2018-09-19 |
Cellectis |
Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
|
|
WO2015126927A2
(en)
|
2014-02-18 |
2015-08-27 |
Duke University |
Compositions for the inactivation of virus replication and methods of making and using the same
|
|
DK3116994T3
(da)
|
2014-02-20 |
2019-10-21 |
Dsm Ip Assets Bv |
Phage-ufølsom streptococcus thermophilus
|
|
CA2939711C
(en)
|
2014-02-21 |
2020-09-29 |
Cellectis |
Method for in situ inhibition of regulatory t cells
|
|
EP3110454B1
(en)
|
2014-02-24 |
2020-11-18 |
Sangamo Therapeutics, Inc. |
Methods and compositions for nuclease-mediated targeted integration
|
|
WO2015127428A1
(en)
|
2014-02-24 |
2015-08-27 |
Massachusetts Institute Of Technology |
Methods for in vivo genome editing
|
|
JP6521669B2
(ja)
|
2014-02-25 |
2019-05-29 |
国立研究開発法人農業・食品産業技術総合研究機構 |
標的dnaに変異が導入された植物細胞、及びその製造方法
|
|
CA2940217C
(en)
|
2014-02-27 |
2023-06-13 |
Monsanto Technology Llc |
Compositions and methods for site directed genomic modification
|
|
CN103820441B
(zh)
|
2014-03-04 |
2017-05-17 |
黄行许 |
CRISPR‑Cas9特异性敲除人CTLA4基因的方法以及用于特异性靶向CTLA4基因的sgRNA
|
|
CN103820454B
(zh)
|
2014-03-04 |
2016-03-30 |
上海金卫生物技术有限公司 |
CRISPR-Cas9特异性敲除人PD1基因的方法以及用于特异性靶向PD1基因的sgRNA
|
|
EP3114227B1
(en)
|
2014-03-05 |
2021-07-21 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa
|
|
ES2752175T3
(es)
|
2014-03-05 |
2020-04-03 |
Univ Kobe Nat Univ Corp |
Método de modificación de la secuencia genómica para convertir específicamente bases de ácido nucleico de una secuencia de ADN seleccionada como diana, y complejo molecular para su uso en el mismo
|
|
US9938521B2
(en)
|
2014-03-10 |
2018-04-10 |
Editas Medicine, Inc. |
CRISPR/CAS-related methods and compositions for treating leber's congenital amaurosis 10 (LCA10)
|
|
WO2015136001A1
(en)
|
2014-03-11 |
2015-09-17 |
Cellectis |
Method for generating t-cells compatible for allogenic transplantation
|
|
JP2017512767A
(ja)
|
2014-03-12 |
2017-05-25 |
プレシジョン バイオサイエンシズ,インク. |
改変ヌクレアーゼを用いたジストロフィン遺伝子エクソンの欠失
|
|
WO2015138870A2
(en)
|
2014-03-13 |
2015-09-17 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for targeted epigenetic modification
|
|
CA2942407C
(en)
|
2014-03-14 |
2023-09-26 |
Cibus Us Llc |
Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
|
|
US20170088845A1
(en)
|
2014-03-14 |
2017-03-30 |
The Regents Of The University Of California |
Vectors and methods for fungal genome engineering by crispr-cas9
|
|
ES2879373T3
(es)
|
2014-03-18 |
2021-11-22 |
Sangamo Therapeutics Inc |
Métodos y composiciones para la regulación de la expresión de proteínas de dedo de zinc
|
|
US10323073B2
(en)
|
2014-03-20 |
2019-06-18 |
UNIVERSITé LAVAL |
CRISPR-based methods and products for increasing frataxin levels and uses thereof
|
|
US10612041B2
(en)
|
2014-03-21 |
2020-04-07 |
The Board Of Trustees Of The Leland Stanford Junior University |
Genome editing without nucleases
|
|
EP3699274A1
(en)
|
2014-03-24 |
2020-08-26 |
Translate Bio, Inc. |
Mrna therapy for the treatment of ocular diseases
|
|
HUE054419T2
(hu)
|
2014-03-24 |
2021-09-28 |
Immco Diagnostics Inc |
Javított antinukleárisellenanyag-kimutatás és diagnosztika szisztémás és nem szisztémás autoimmun betegségekhez
|
|
EP3122870B1
(en)
|
2014-03-25 |
2022-06-29 |
Ginkgo Bioworks Inc. |
Methods and genetic systems for cell engineering
|
|
CA2943622A1
(en)
|
2014-03-25 |
2015-10-01 |
Editas Medicine Inc. |
Crispr/cas-related methods and compositions for treating hiv infection and aids
|
|
WO2015148863A2
(en)
|
2014-03-26 |
2015-10-01 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating sickle cell disease
|
|
WO2015148860A1
(en)
|
2014-03-26 |
2015-10-01 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating beta-thalassemia
|
|
CN106459951A
(zh)
|
2014-03-26 |
2017-02-22 |
马里兰大学派克分院 |
驯养的大型动物的受精卵中的靶向基因组编辑
|
|
WO2015145417A1
(en)
|
2014-03-28 |
2015-10-01 |
Ilan Ziv |
Compounds and methods for trans-membrane delivery of molecules
|
|
US9993563B2
(en)
|
2014-03-28 |
2018-06-12 |
Aposense Ltd. |
Compounds and methods for trans-membrane delivery of molecules
|
|
WO2015153789A1
(en)
|
2014-04-01 |
2015-10-08 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating herpes simplex virus type 1 (hsv-1)
|
|
WO2015153791A1
(en)
|
2014-04-01 |
2015-10-08 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating herpes simplex virus type 2 (hsv-2)
|
|
WO2015153760A2
(en)
|
2014-04-01 |
2015-10-08 |
Sangamo Biosciences, Inc. |
Methods and compositions for prevention or treatment of a nervous system disorder
|
|
EP3126495A1
(en)
|
2014-04-02 |
2017-02-08 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating primary open angle glaucoma
|
|
WO2015153889A2
(en)
|
2014-04-02 |
2015-10-08 |
University Of Florida Research Foundation, Incorporated |
Materials and methods for the treatment of latent viral infection
|
|
EP3126503A1
(en)
|
2014-04-03 |
2017-02-08 |
Massachusetts Institute Of Technology |
Methods and compositions for the production of guide rna
|
|
CN103911376B
(zh)
|
2014-04-03 |
2017-02-15 |
黄行许 |
CRISPR‑Cas9靶向敲除乙肝病毒cccDNA及其特异性sgRNA
|
|
CA2944978C
(en)
|
2014-04-08 |
2024-02-13 |
North Carolina State University |
Methods and compositions for rna-directed repression of transcription using crispr-associated genes
|
|
EP3129485B2
(en)
|
2014-04-09 |
2022-12-21 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating cystic fibrosis
|
|
US10253311B2
(en)
|
2014-04-10 |
2019-04-09 |
The Regents Of The University Of California |
Methods and compositions for using argonaute to modify a single stranded target nucleic acid
|
|
JP2017513472A
(ja)
|
2014-04-11 |
2017-06-01 |
セレクティスCellectis |
アルギニンおよび/またはトリプトファン枯渇微小環境に対して抵抗性を有する免疫細胞を作製するための方法
|
|
EP3132025B1
(en)
|
2014-04-14 |
2023-08-30 |
Maxcyte, Inc. |
Methods and compositions for modifying genomic dna
|
|
CN103923911B
(zh)
|
2014-04-14 |
2016-06-08 |
上海金卫生物技术有限公司 |
CRISPR-Cas9特异性敲除人CCR5基因的方法以及用于特异性靶向CCR5基因的sgRNA
|
|
EP3132034B1
(en)
|
2014-04-14 |
2020-08-19 |
Nemesis Bioscience Ltd. |
Therapeutic
|
|
GB201406968D0
(en)
|
2014-04-17 |
2014-06-04 |
Green Biologics Ltd |
Deletion mutants
|
|
GB201406970D0
(en)
|
2014-04-17 |
2014-06-04 |
Green Biologics Ltd |
Targeted mutations
|
|
SG10201912171PA
(en)
|
2014-04-18 |
2020-02-27 |
Editas Medicine Inc |
Crispr-cas-related methods, compositions and components for cancer immunotherapy
|
|
CN105039399A
(zh)
|
2014-04-23 |
2015-11-11 |
复旦大学 |
多能干细胞-遗传性心肌病心肌细胞及其制备方法
|
|
WO2015164748A1
(en)
|
2014-04-24 |
2015-10-29 |
Sangamo Biosciences, Inc. |
Engineered transcription activator like effector (tale) proteins
|
|
CA2945393C
(en)
|
2014-04-24 |
2021-03-23 |
Board Of Regents, The University Of Texas System |
Application of induced pluripotent stem cells to generate adoptive cell therapy products
|
|
KR101823661B1
(ko)
|
2014-04-24 |
2018-01-30 |
기초과학연구원 |
마이크로 상동 기반의 유전자 녹아웃을 위한 뉴클레아제 표적 서열을 확인하는 방법
|
|
EP3136842A4
(en)
|
2014-04-28 |
2017-11-29 |
Dow AgroSciences LLC |
Haploid maize transformation
|
|
WO2015168158A1
(en)
|
2014-04-28 |
2015-11-05 |
Fredy Altpeter |
Targeted genome editing to modify lignin biosynthesis and cell wall composition
|
|
BR112016024945A2
(pt)
|
2014-04-28 |
2017-10-24 |
Recombinetics Inc |
edição de gene multiplex em suínos
|
|
GB2540694A
(en)
|
2014-04-29 |
2017-01-25 |
Seattle Children's Hospital (Dba Seattle Children's Res Institute) |
CCR5 disruption of cells expressing anti-hiv chimeric antigen receptor (CAR) derived from broadly neutralizing antibodies
|
|
WO2015168404A1
(en)
|
2014-04-30 |
2015-11-05 |
Massachusetts Institute Of Technology |
Toehold-gated guide rna for programmable cas9 circuitry with rna input
|
|
WO2015165276A1
(zh)
|
2014-04-30 |
2015-11-05 |
清华大学 |
利用tale转录抑制子在哺乳动物细胞中模块化构建合成基因线路的试剂盒
|
|
EP3636765A1
(en)
|
2014-04-30 |
2020-04-15 |
Tsinghua University |
Use of tale transcriptional repressor for modulator construction of synthetic gene line in mammalian cells
|
|
CN104178506B
(zh)
|
2014-04-30 |
2017-03-01 |
清华大学 |
Taler蛋白通过空间位阻发挥转录抑制作用及其应用
|
|
CA2947466A1
(en)
|
2014-05-01 |
2015-11-05 |
University Of Washington |
In vivo gene engineering with adenoviral vectors
|
|
GB201407852D0
(en)
|
2014-05-02 |
2014-06-18 |
Iontas Ltd |
Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules
|
|
WO2015171603A1
(en)
|
2014-05-06 |
2015-11-12 |
Two Blades Foundation |
Methods for producing plants with enhanced resistance to oomycete pathogens
|
|
EP3139966B1
(en)
|
2014-05-08 |
2020-11-18 |
Sangamo Therapeutics, Inc. |
Compositions for use in treating huntington's disease
|
|
CA2948580A1
(en)
|
2014-05-09 |
2015-11-12 |
Adam Zlotnick |
Methods and compositions for treating hepatitis b virus infections
|
|
US10487336B2
(en)
|
2014-05-09 |
2019-11-26 |
The Regents Of The University Of California |
Methods for selecting plants after genome editing
|
|
WO2015168800A1
(en)
|
2014-05-09 |
2015-11-12 |
UNIVERSITé LAVAL |
Prevention and treatment of alzheimer's disease by genome editing using the crispr/cas system
|
|
EP3142707A4
(en)
|
2014-05-13 |
2018-02-21 |
Sangamo Therapeutics, Inc. |
Methods and compositions for prevention or treatment of a disease
|
|
CN103981211B
(zh)
|
2014-05-16 |
2016-07-06 |
安徽省农业科学院水稻研究所 |
一种创制闭颖授粉水稻材料的育种方法
|
|
CN104004782B
(zh)
|
2014-05-16 |
2016-06-08 |
安徽省农业科学院水稻研究所 |
一种延长水稻生育期的育种方法
|
|
CN103981212B
(zh)
|
2014-05-16 |
2016-06-01 |
安徽省农业科学院水稻研究所 |
将黄色颖壳的水稻品种的颖壳颜色改为褐色的育种方法
|
|
CN104017821B
(zh)
|
2014-05-16 |
2016-07-06 |
安徽省农业科学院水稻研究所 |
定向编辑颖壳颜色决定基因OsCHI创制褐壳水稻材料的方法
|
|
EP3142706A1
(en)
|
2014-05-16 |
2017-03-22 |
Vrije Universiteit Brussel |
Genetic correction of myotonic dystrophy type 1
|
|
US20170175143A1
(en)
|
2014-05-20 |
2017-06-22 |
Regents Of The University Of Minnesota |
Method for editing a genetic sequence
|
|
CA2852593A1
(en)
|
2014-05-23 |
2015-11-23 |
Universite Laval |
Methods for producing dopaminergic neurons and uses thereof
|
|
US10653123B2
(en)
|
2014-05-27 |
2020-05-19 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions for perturbing gene expression in hematopoietic stem cell lineages in vivo
|
|
EP3150718A4
(en)
|
2014-05-28 |
2018-03-28 |
Toolgen Incorporated |
Method for sensitive detection of target dna using target-specific nuclease
|
|
CN107002094A
(zh)
|
2014-05-30 |
2017-08-01 |
斯坦福大学托管董事会 |
用于治疗潜伏病毒感染的组合物和方法
|
|
EP3152319A4
(en)
|
2014-06-05 |
2017-12-27 |
Sangamo BioSciences, Inc. |
Methods and compositions for nuclease design
|
|
US11030531B2
(en)
|
2014-06-06 |
2021-06-08 |
Trustees Of Boston University |
DNA recombinase circuits for logical control of gene expression
|
|
US20170198307A1
(en)
|
2014-06-06 |
2017-07-13 |
President And Fellows Of Harvard College |
Methods for targeted modification of genomic dna
|
|
WO2015188132A1
(en)
|
2014-06-06 |
2015-12-10 |
The California Institute For Biomedical Research |
Methods of constructing amino terminal immunoglobulin fusion proteins and compositions thereof
|
|
CN104004778B
(zh)
|
2014-06-06 |
2016-03-02 |
重庆高圣生物医药有限责任公司 |
含有CRISPR/Cas9系统的靶向敲除载体及其腺病毒和应用
|
|
ES3019688T3
(en)
|
2014-06-06 |
2025-05-21 |
Regeneron Pharma |
Methods and compositions for modifying a targeted locus
|
|
US20170210818A1
(en)
|
2014-06-06 |
2017-07-27 |
The California Institute For Biomedical Research |
Constant region antibody fusion proteins and compositions thereof
|
|
WO2015191693A2
(en)
|
2014-06-10 |
2015-12-17 |
Massachusetts Institute Of Technology |
Method for gene editing
|
|
US11274302B2
(en)
|
2016-08-17 |
2022-03-15 |
Diacarta Ltd |
Specific synthetic chimeric Xenonucleic acid guide RNA; s(XNA-gRNA) for enhancing CRISPR mediated genome editing efficiency
|
|
US10662426B2
(en)
|
2014-06-11 |
2020-05-26 |
Duke University |
Compositions and methods for rapid and dynamic flux control using synthetic metabolic valves
|
|
WO2015191899A1
(en)
|
2014-06-11 |
2015-12-17 |
Howard Tom E |
FACTOR VIII MUTATION REPAIR AND TOLERANCE INDUCTION AND RELATED CDNAs, COMPOSITIONS, METHODS AND SYSTEMS
|
|
WO2015191911A2
(en)
|
2014-06-12 |
2015-12-17 |
Clontech Laboratories, Inc. |
Protein enriched microvesicles and methods of making and using the same
|
|
WO2015189693A1
(en)
|
2014-06-12 |
2015-12-17 |
King Abdullah University Of Science And Technology |
Targeted viral-mediated plant genome editing using crispr/cas9
|
|
WO2015195547A1
(en)
|
2014-06-16 |
2015-12-23 |
University Of Washington |
Methods for controlling stem cell potential and for gene editing in stem cells
|
|
EP3155101B1
(en)
|
2014-06-16 |
2020-01-29 |
The Johns Hopkins University |
Compositions and methods for the expression of crispr guide rnas using the h1 promoter
|
|
US20170107541A1
(en)
|
2014-06-17 |
2017-04-20 |
Poseida Therapeutics, Inc. |
A method for directing proteins to specific loci in the genome and uses thereof
|
|
US10301637B2
(en)
|
2014-06-20 |
2019-05-28 |
Cellectis |
Potatoes with reduced granule-bound starch synthase
|
|
CN106604994B
(zh)
|
2014-06-23 |
2021-12-14 |
通用医疗公司 |
通过测序评估的DSBs的全基因组无偏鉴定(GUIDE-Seq)
|
|
ES2666179T3
(es)
|
2014-06-23 |
2018-05-03 |
Regeneron Pharmaceuticals, Inc. |
Montaje de ADN mediado por nucleasas
|
|
WO2015200555A2
(en)
|
2014-06-25 |
2015-12-30 |
Caribou Biosciences, Inc. |
Rna modification to engineer cas9 activity
|
|
GB201411344D0
(en)
|
2014-06-26 |
2014-08-13 |
Univ Leicester |
Cloning
|
|
ES2901074T3
(es)
|
2014-06-26 |
2022-03-21 |
Regeneron Pharma |
Métodos y composiciones para modificaciones genéticas objetivo y métodos de uso
|
|
SG11201610591XA
(en)
|
2014-06-30 |
2017-01-27 |
Kao Corp |
Adhesive sheet for cooling
|
|
JP6090535B2
(ja)
|
2014-06-30 |
2017-03-08 |
日産自動車株式会社 |
内燃機関
|
|
WO2016004010A1
(en)
|
2014-07-01 |
2016-01-07 |
Board Of Regents, The University Of Texas System |
Regulated gene expression from viral vectors
|
|
BR112016030852A2
(pt)
|
2014-07-02 |
2018-01-16 |
Shire Human Genetic Therapies |
encapsulação de rna mensageiro
|
|
WO2016007604A1
(en)
|
2014-07-09 |
2016-01-14 |
Gen9, Inc. |
Compositions and methods for site-directed dna nicking and cleaving
|
|
EP2966170A1
(en)
|
2014-07-10 |
2016-01-13 |
Heinrich-Pette-Institut Leibniz-Institut für experimentelle Virologie-Stiftung bürgerlichen Rechts - |
HBV inactivation
|
|
CN106795524A
(zh)
|
2014-07-11 |
2017-05-31 |
先锋国际良种公司 |
使用向导rna/cas内切核酸酶系统改变农学性状及其使用方法
|
|
AU2015288157A1
(en)
|
2014-07-11 |
2017-01-19 |
E. I. Du Pont De Nemours And Company |
Compositions and methods for producing plants resistant to glyphosate herbicide
|
|
CN104109687A
(zh)
|
2014-07-14 |
2014-10-22 |
四川大学 |
运动发酵单胞菌CRISPR-Cas9系统的构建与应用
|
|
WO2016011080A2
(en)
|
2014-07-14 |
2016-01-21 |
The Regents Of The University Of California |
Crispr/cas transcriptional modulation
|
|
MA40253A
(fr)
|
2014-07-15 |
2017-05-24 |
Juno Therapeutics Inc |
Cellules modifiées pour thérapie cellulaire adoptive
|
|
WO2016011428A1
(en)
|
2014-07-17 |
2016-01-21 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Methods of treating cells containing fusion genes
|
|
US9944933B2
(en)
|
2014-07-17 |
2018-04-17 |
Georgia Tech Research Corporation |
Aptamer-guided gene targeting
|
|
US20160053304A1
(en)
|
2014-07-18 |
2016-02-25 |
Whitehead Institute For Biomedical Research |
Methods Of Depleting Target Sequences Using CRISPR
|
|
US10975406B2
(en)
|
2014-07-18 |
2021-04-13 |
Massachusetts Institute Of Technology |
Directed endonucleases for repeatable nucleic acid cleavage
|
|
US20160053272A1
(en)
|
2014-07-18 |
2016-02-25 |
Whitehead Institute For Biomedical Research |
Methods Of Modifying A Sequence Using CRISPR
|
|
AU2015292744C1
(en)
|
2014-07-21 |
2021-01-21 |
Novartis Ag |
Treatment of cancer using humanized anti-BCMA chimeric antigen receptor
|
|
CN107109401B
(zh)
|
2014-07-21 |
2021-02-19 |
亿明达股份有限公司 |
使用crispr-cas系统的多核苷酸富集
|
|
DE112015003386T5
(de)
|
2014-07-22 |
2017-03-30 |
Panasonic Intellectual Property Management Co., Ltd. |
Magnetisches Verbundmaterial, Spulenkomponente, die dasselbe verwendet und Herstellungsverfahren für das magnetische Verbundmaterial
|
|
EP3172315B1
(en)
|
2014-07-24 |
2020-09-30 |
DSM IP Assets B.V. |
Phage resistant lactic acid bacteria
|
|
US9816074B2
(en)
|
2014-07-25 |
2017-11-14 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
|
|
JP2017525347A
(ja)
|
2014-07-25 |
2017-09-07 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
iPS細胞への再プログラミングの増強
|
|
WO2016014837A1
(en)
|
2014-07-25 |
2016-01-28 |
Sangamo Biosciences, Inc. |
Gene editing for hiv gene therapy
|
|
EP3194600B1
(en)
|
2014-07-26 |
2019-08-28 |
Consiglio Nazionale Delle Ricerche |
Compositions and methods for treatment of muscular dystrophy
|
|
WO2016019144A2
(en)
|
2014-07-30 |
2016-02-04 |
Sangamo Biosciences, Inc. |
Gene correction of scid-related genes in hematopoietic stem and progenitor cells
|
|
EP3177718B1
(en)
|
2014-07-30 |
2022-03-16 |
President and Fellows of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
FR3024464A1
(fr)
|
2014-07-30 |
2016-02-05 |
Centre Nat Rech Scient |
Ciblage de vecteurs integratifs non-viraux dans les sequences d'adn nucleolaires chez les eucaryotes
|
|
US9850521B2
(en)
|
2014-08-01 |
2017-12-26 |
Agilent Technologies, Inc. |
In vitro assay buffer for Cas9
|
|
EP2982758A1
(en)
|
2014-08-04 |
2016-02-10 |
Centre Hospitalier Universitaire Vaudois (CHUV) |
Genome editing for the treatment of huntington's disease
|
|
US20160076093A1
(en)
|
2014-08-04 |
2016-03-17 |
University Of Washington |
Multiplex homology-directed repair
|
|
KR101826904B1
(ko)
|
2014-08-06 |
2018-02-08 |
기초과학연구원 |
조직적합성항원 유전자들의 교정을 통하여 구축한, 면역적합형 세포
|
|
EP4194557A1
(en)
|
2014-08-06 |
2023-06-14 |
Institute for Basic Science |
Genome editing using campylobacter jejuni crispr/cas system-derived rgen
|
|
US9932566B2
(en)
|
2014-08-07 |
2018-04-03 |
Agilent Technologies, Inc. |
CIS-blocked guide RNA
|
|
WO2016022931A1
(en)
|
2014-08-07 |
2016-02-11 |
The Rockefeller University |
Compositions and methods for transcription-based crispr-cas dna editing
|
|
CN106714845A
(zh)
|
2014-08-11 |
2017-05-24 |
得克萨斯州大学系统董事会 |
通过crispr/cas9介导的基因编辑预防肌营养不良
|
|
US10513711B2
(en)
|
2014-08-13 |
2019-12-24 |
Dupont Us Holding, Llc |
Genetic targeting in non-conventional yeast using an RNA-guided endonuclease
|
|
CN104178461B
(zh)
|
2014-08-14 |
2017-02-01 |
北京蛋白质组研究中心 |
携带cas9的重组腺病毒及其应用
|
|
US11071289B2
(en)
|
2014-08-14 |
2021-07-27 |
Biocytogen Boston Corp |
DNA knock-in system
|
|
US9879270B2
(en)
|
2014-08-15 |
2018-01-30 |
Wisconsin Alumni Research Foundation |
Constructs and methods for genome editing and genetic engineering of fungi and protists
|
|
EP3686279B1
(en)
|
2014-08-17 |
2023-01-04 |
The Broad Institute, Inc. |
Genome editing using cas9 nickases
|
|
EP3633047B1
(en)
|
2014-08-19 |
2022-12-28 |
Pacific Biosciences of California, Inc. |
Method of sequencing nucleic acids based on an enrichment of nucleic acids
|
|
CN107075546B
(zh)
|
2014-08-19 |
2021-08-31 |
哈佛学院董事及会员团体 |
用于对核酸探测并作图的rna-引导的系统
|
|
WO2016026444A1
(en)
|
2014-08-20 |
2016-02-25 |
Shanghai Institutes For Biological Sciences, Chinese Academy Of Sciences |
Biomarker and therapeutic target for triple negative breast cancer
|
|
SG11201701273PA
(en)
|
2014-08-25 |
2017-03-30 |
Geneweave Biosciences Inc |
Non-replicative transduction particles and transduction particle-based reporter systems
|
|
CA2958767A1
(en)
|
2014-08-26 |
2016-03-03 |
The Regents Of The University Of California |
Hypersensitive aba receptors
|
|
NZ728437A
(en)
|
2014-08-27 |
2018-02-23 |
Caribou Biosciences Inc |
Methods for increasing cas9-mediated engineering efficiency
|
|
EP3186375A4
(en)
|
2014-08-28 |
2019-03-13 |
North Carolina State University |
Novel CAS9 PROTEINS AND CHARACTERISTICS FOR DNA TARGETING AND GENOME EDITING
|
|
WO2016036754A1
(en)
|
2014-09-02 |
2016-03-10 |
The Regents Of The University Of California |
Methods and compositions for rna-directed target dna modification
|
|
EP3188746B1
(en)
|
2014-09-05 |
2024-06-19 |
The Johns Hopkins University |
Targeting capn9 activity as a therapeutic strategy for the treatment of myofibroblast differentiation and associated pathologies
|
|
DK3189140T3
(en)
|
2014-09-05 |
2020-02-03 |
Univ Vilnius |
Programmerbar RNA-fragmentering ved hjælp af TYPE III-A CRISPR-Cas-systemet af Streptococcus thermophilus
|
|
US20170298450A1
(en)
|
2014-09-10 |
2017-10-19 |
The Regents Of The University Of California |
Reconstruction of ancestral cells by enzymatic recording
|
|
RU2017112324A
(ru)
|
2014-09-12 |
2018-10-15 |
Пайонир Хай-Бред Интернэшнл, Инк. |
Создание сайтов сайт-специфической интеграции для сложных локусов признаков в кукурузе и сое, а также способы применения
|
|
ES2835717T3
(es)
|
2014-09-16 |
2021-06-23 |
Gilead Sciences Inc |
Formas sólidas de un modulador de receptor de tipo Toll
|
|
RS62334B1
(sr)
|
2014-09-16 |
2021-10-29 |
Sangamo Therapeutics Inc |
Postupci i sastavi za inženjering genoma posredovan nukleazom i korekciju kod matičnih ćelija hematopoeze
|
|
WO2016049163A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder
|
|
CA2961555A1
(en)
|
2014-09-24 |
2016-03-31 |
City Of Hope |
Adeno-associated virus vector variants for high efficiency genome editing and methods thereof
|
|
WO2016049024A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling competition of multiple cancer mutations in vivo
|
|
WO2016049251A1
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling mutations in leukocytes
|
|
WO2016049258A2
(en)
|
2014-09-25 |
2016-03-31 |
The Broad Institute Inc. |
Functional screening with optimized functional crispr-cas systems
|
|
WO2016046635A1
(en)
|
2014-09-25 |
2016-03-31 |
Institut Pasteur |
Methods for characterizing human papillomavirus associated cervical lesions
|
|
US20160090603A1
(en)
|
2014-09-30 |
2016-03-31 |
Sandia Corporation |
Delivery platforms for the domestication of algae and plants
|
|
AU2015324935B2
(en)
|
2014-10-01 |
2021-04-08 |
The General Hospital Corporation |
Methods for increasing efficiency of nuclease-induced homology-directed repair
|
|
AU2015330775B2
(en)
|
2014-10-09 |
2021-06-24 |
Seattle Children' S Hospital (Dba Seattle Children' S Research Institute) |
Long poly (A) plasmids and methods for introduction of long poly (A) sequences into the plasmid
|
|
US9879283B2
(en)
|
2014-10-09 |
2018-01-30 |
Life Technologies Corporation |
CRISPR oligonucleotides and gene editing
|
|
EP3204032B1
(en)
|
2014-10-10 |
2024-03-27 |
Massachusetts Eye & Ear Infirmary |
Chimeric molecule comprising crispr/cas or cas9 nuclease and at least one guide rna targeting pmca2 gene locus and fused, complexed or linked to an anionic fluorescent protein, and its use in the treatment of deafness or disorders thereof
|
|
US20180250424A1
(en)
|
2014-10-10 |
2018-09-06 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
|
WO2016061073A1
(en)
|
2014-10-14 |
2016-04-21 |
Memorial Sloan-Kettering Cancer Center |
Composition and method for in vivo engineering of chromosomal rearrangements
|
|
BR112017007770A2
(pt)
|
2014-10-15 |
2018-01-16 |
Regeneron Pharma |
cultura in vitro, população de hipscs, método para modificar um locus-alvo genômico, e, hipsc.
|
|
CN107027313B
(zh)
|
2014-10-17 |
2021-09-07 |
宾州研究基金会 |
用于多元rna引导的基因组编辑和其它rna技术的方法和组合物
|
|
CN107208086A
(zh)
|
2014-10-17 |
2017-09-26 |
霍华德休斯医学研究所 |
基因组探针
|
|
JP2017536813A
(ja)
|
2014-10-20 |
2017-12-14 |
エンバイロロジックス インコーポレイテッド |
Rnaウイルスを検出するための組成物及び方法
|
|
US20170247762A1
(en)
|
2014-10-27 |
2017-08-31 |
The Board Institute Inc. |
Compositions, methods and use of synthetic lethal screening
|
|
CN107075491B
(zh)
|
2014-10-28 |
2021-07-06 |
谷万达公司 |
用于稳定反式剪接的内含肽修饰的蛋白酶的方法和组合物
|
|
EP3212221B1
(en)
|
2014-10-29 |
2023-12-06 |
Massachusetts Eye & Ear Infirmary |
Efficient delivery of therapeutic molecules in vitro and in vivo
|
|
EP4434997A3
(en)
|
2014-10-30 |
2025-01-01 |
President And Fellows Of Harvard College |
Delivery of negatively charged proteins using cationic lipids
|
|
MA40880A
(fr)
|
2014-10-30 |
2017-09-05 |
Temple Univ Of The Commonwealth |
Éradication guidée par l'arn du virus jc humain et d'autres polyomavirus
|
|
DK3212789T3
(da)
|
2014-10-31 |
2020-07-27 |
Massachusetts Inst Technology |
Massiv parallel kombinatorisk genetik til crispr
|
|
US9816080B2
(en)
|
2014-10-31 |
2017-11-14 |
President And Fellows Of Harvard College |
Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
|
|
WO2016069283A1
(en)
|
2014-10-31 |
2016-05-06 |
The Trustees Of The University Of Pennsylvania |
Altering gene expression in cart cells and uses thereof
|
|
CN104504304B
(zh)
|
2014-11-03 |
2017-08-25 |
深圳先进技术研究院 |
一种成簇的规律间隔的短回文重复序列识别方法及装置
|
|
CN104404036B
(zh)
|
2014-11-03 |
2017-12-01 |
赛业(苏州)生物科技有限公司 |
基于CRISPR/Cas9技术的条件性基因敲除方法
|
|
SG11201703528YA
(en)
|
2014-11-03 |
2017-05-30 |
Univ Nanyang Tech |
A recombinant expression system that senses pathogenic microorganisms
|
|
WO2016072399A1
(ja)
|
2014-11-04 |
2016-05-12 |
国立大学法人神戸大学 |
脱塩基反応により標的化したdna配列に特異的に変異を導入する、ゲノム配列の改変方法、並びにそれに用いる分子複合体
|
|
WO2016073559A1
(en)
|
2014-11-05 |
2016-05-12 |
The Regents Of The University Of California |
Methods for autocatalytic genome editing and neutralizing autocatalytic genome editing
|
|
US10208298B2
(en)
|
2014-11-06 |
2019-02-19 |
E.I. Du Pont De Nemours And Company |
Peptide-mediated delivery of RNA-guided endonuclease into cells
|
|
EP3215617B1
(en)
|
2014-11-07 |
2024-05-08 |
Editas Medicine, Inc. |
Systems for improving crispr/cas-mediated genome-editing
|
|
US20170369848A1
(en)
|
2014-11-11 |
2017-12-28 |
Q Therapeutics, Inc. |
Engineering mesenchymal stem cells using homologous recombination
|
|
SG11201703779VA
(en)
|
2014-11-11 |
2017-06-29 |
Illumina Inc |
Polynucleotide amplification using crispr-cas systems
|
|
JP6621820B2
(ja)
|
2014-11-14 |
2019-12-18 |
インスティチュート フォー ベーシック サイエンスInstitute For Basic Science |
ゲノムでプログラマブルヌクレアーゼの非標的位置を検出する方法
|
|
EP3467110A1
(en)
|
2014-11-15 |
2019-04-10 |
Zumutor Biologics Inc. |
Dna-binding domain, non-fucosylated and partially fucosylated proteins, and methods thereof
|
|
JP6190995B2
(ja)
|
2014-11-17 |
2017-09-06 |
国立大学法人 東京医科歯科大学 |
簡便で高効率の遺伝子改変非ヒト哺乳動物の作製方法
|
|
EP3222728B1
(en)
|
2014-11-19 |
2021-07-14 |
Institute for Basic Science |
Method for regulating gene expression using cas9 protein expressed from two vectors
|
|
WO2016081924A1
(en)
|
2014-11-20 |
2016-05-26 |
Duke University |
Compositions, systems and methods for cell therapy
|
|
US10227661B2
(en)
|
2014-11-21 |
2019-03-12 |
GeneWeave Biosciences, Inc. |
Sequence-specific detection and phenotype determination
|
|
SG11201703747RA
(en)
|
2014-11-21 |
2017-06-29 |
Regeneron Pharma |
METHODS AND COMPOSITIONS FOR TARGETED GENETIC MODIFICATION USING PAIRED GUIDE RNAs
|
|
WO2016086177A2
(en)
|
2014-11-25 |
2016-06-02 |
Drexel University |
Compositions and methods for hiv quasi-species excision from hiv-1-infected patients
|
|
EP3224353B9
(en)
|
2014-11-26 |
2023-08-09 |
Technology Innovation Momentum Fund (Israel) Limited Partnership |
Targeted elimination of bacterial genes
|
|
CN105695485B
(zh)
|
2014-11-27 |
2020-02-21 |
中国科学院上海生命科学研究院 |
一种用于丝状真菌Crispr-Cas系统的Cas9编码基因及其应用
|
|
GB201421096D0
(en)
|
2014-11-27 |
2015-01-14 |
Imp Innovations Ltd |
Genome editing methods
|
|
WO2016082135A1
(zh)
|
2014-11-27 |
2016-06-02 |
中国农业科学院北京畜牧兽医研究所 |
一种利用定点切割系统对猪h11位点定点插入的方法
|
|
EP3224363B1
(en)
|
2014-11-27 |
2021-11-03 |
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. |
Nucleic acid constructs for genome editing
|
|
EP3227446A1
(en)
|
2014-12-01 |
2017-10-11 |
Novartis AG |
Compositions and methods for diagnosis and treatment of prostate cancer
|
|
WO2016089866A1
(en)
|
2014-12-01 |
2016-06-09 |
President And Fellows Of Harvard College |
Rna-guided systems for in vivo gene editing
|
|
US10900034B2
(en)
|
2014-12-03 |
2021-01-26 |
Agilent Technologies, Inc. |
Guide RNA with chemical modifications
|
|
CN104450774A
(zh)
|
2014-12-04 |
2015-03-25 |
中国农业科学院作物科学研究所 |
一种大豆CRISPR/Cas9体系的构建及其在大豆基因修饰中的应用
|
|
WO2016090385A1
(en)
|
2014-12-05 |
2016-06-09 |
Applied Stemcell, Inc. |
Site-directed crispr/recombinase compositions and methods of integrating transgenes
|
|
CN104531705A
(zh)
|
2014-12-09 |
2015-04-22 |
中国农业大学 |
利用CRISPR-Cas9系统敲除动物myostatin基因的方法
|
|
CN104531704B
(zh)
|
2014-12-09 |
2019-05-21 |
中国农业大学 |
利用CRISPR-Cas9系统敲除动物FGF5基因的方法
|
|
CN116059378A
(zh)
|
2014-12-10 |
2023-05-05 |
明尼苏达大学董事会 |
用于治疗疾病的遗传修饰的细胞、组织和器官
|
|
WO2016094874A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Escorted and functionalized guides for crispr-cas systems
|
|
US12359197B2
(en)
|
2014-12-12 |
2025-07-15 |
Etagen Pharma, Inc. |
Compositions and methods for editing nucleic acids in cells utilizing oligonucleotides
|
|
EP3889260A1
(en)
|
2014-12-12 |
2021-10-06 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
EP3230452B1
(en)
|
2014-12-12 |
2025-06-11 |
The Broad Institute, Inc. |
Dead guides for crispr transcription factors
|
|
CN107249645A
(zh)
|
2014-12-12 |
2017-10-13 |
朱坚 |
用于选择性消除所关注细胞的方法和组合物
|
|
CN104480144B
(zh)
|
2014-12-12 |
2017-04-12 |
武汉大学 |
用于艾滋病基因治疗的CRISPR/Cas9重组慢病毒载体及其慢病毒
|
|
WO2016094880A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs)
|
|
CN113215115B
(zh)
|
2014-12-16 |
2024-07-02 |
C3J治疗公司 |
用于体外病毒基因组工程的组合物和方法
|
|
WO2016100272A1
(en)
|
2014-12-16 |
2016-06-23 |
Danisco Us Inc |
Fungal genome modification systems and methods of use
|
|
DK3234134T3
(da)
|
2014-12-17 |
2020-07-27 |
Proqr Therapeutics Ii Bv |
Målrettet rna-redigering
|
|
CA2971391C
(en)
|
2014-12-17 |
2023-05-09 |
E. I. Du Pont De Nemours And Company |
Compositions and methods for efficient gene editing in e. coli using guide rna/cas endonuclease systems in combination with circular polynucleotide modification templates.
|
|
JP2018504104A
(ja)
|
2014-12-17 |
2018-02-15 |
セレクティスCellectis |
非T細胞伝達ドメインを発現する阻害性キメラ抗原受容体(iCARまたはN−CAR)
|
|
WO2016097751A1
(en)
|
2014-12-18 |
2016-06-23 |
The University Of Bath |
Method of cas9 mediated genome engineering
|
|
CA2970683A1
(en)
|
2014-12-18 |
2016-06-23 |
Integrated Dna Technologies, Inc. |
Crispr-based compositions and methods of use
|
|
EP3234192B1
(en)
|
2014-12-19 |
2021-07-14 |
The Broad Institute, Inc. |
Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing
|
|
CN104745626B
(zh)
|
2014-12-19 |
2018-05-01 |
中国航天员科研训练中心 |
一种条件性基因敲除动物模型的快速构建方法及应用
|
|
WO2016100955A2
(en)
|
2014-12-20 |
2016-06-23 |
Identifygenomics, Llc |
Compositions and methods for targeted depletion, enrichment, and partitioning of nucleic acids using crispr/cas system proteins
|
|
US10190106B2
(en)
|
2014-12-22 |
2019-01-29 |
Univesity Of Massachusetts |
Cas9-DNA targeting unit chimeras
|
|
CN104560864B
(zh)
|
2014-12-22 |
2017-08-11 |
中国科学院微生物研究所 |
利用CRISPR‑Cas9系统构建的敲除IFN‑β基因的293T细胞系
|
|
WO2016106236A1
(en)
|
2014-12-23 |
2016-06-30 |
The Broad Institute Inc. |
Rna-targeting system
|
|
WO2016106239A1
(en)
|
2014-12-23 |
2016-06-30 |
The Regents Of The University Of California |
Methods and compositions for nucleic acid integration
|
|
AU2015101792A4
(en)
|
2014-12-24 |
2016-01-28 |
Massachusetts Institute Of Technology |
Engineering of systems, methods and optimized enzyme and guide scaffolds for sequence manipulation
|
|
CN104651398A
(zh)
|
2014-12-24 |
2015-05-27 |
杭州师范大学 |
利用CRISPR-Cas9特异敲出microRNA基因家族的方法
|
|
EP3702456A1
(en)
|
2014-12-24 |
2020-09-02 |
The Broad Institute, Inc. |
Crispr having or associated with destabilization domains
|
|
AU2015370435A1
(en)
|
2014-12-24 |
2017-06-15 |
Dana-Farber Cancer Institute, Inc. |
Systems and methods for genome modification and regulation
|
|
EP3239298A4
(en)
|
2014-12-26 |
2018-06-13 |
Riken |
Gene knockout method
|
|
CN104498493B
(zh)
|
2014-12-30 |
2017-12-26 |
武汉大学 |
CRISPR/Cas9特异性敲除乙型肝炎病毒的方法以及用于特异性靶向HBV DNA的gRNA
|
|
US20180002706A1
(en)
|
2014-12-30 |
2018-01-04 |
University Of South Florida |
Methods and compositions for cloning into large vectors
|
|
WO2016108926A1
(en)
|
2014-12-30 |
2016-07-07 |
The Broad Institute Inc. |
Crispr mediated in vivo modeling and genetic screening of tumor growth and metastasis
|
|
CN104651399B
(zh)
|
2014-12-31 |
2018-11-16 |
广西大学 |
一种利用CRISPR/Cas系统在猪胚胎细胞中实现基因敲除的方法
|
|
CA2972454A1
(en)
|
2014-12-31 |
2016-07-07 |
Synthetic Genomics, Inc. |
Compositions and methods for high efficiency in vivo genome editing
|
|
CN104651392B
(zh)
|
2015-01-06 |
2018-07-31 |
华南农业大学 |
一种利用CRISPR/Cas9系统定点突变P/TMS12-1获得温敏不育系的方法
|
|
EP3242950B1
(en)
|
2015-01-06 |
2021-10-06 |
DSM IP Assets B.V. |
A crispr-cas system for a filamentous fungal host cell
|
|
DK3242949T3
(da)
|
2015-01-06 |
2022-01-24 |
Dsm Ip Assets Bv |
Crispr-cas-system til en gærværtscelle
|
|
JP6603721B2
(ja)
|
2015-01-06 |
2019-11-06 |
インダストリー−アカデミック コーポレーション ファウンデーション,ヨンセイ ユニバーシティ |
血液凝固因子viii遺伝子をターゲットとするエンドヌクレアーゼ及びそれを含む血友病治療用組成物
|
|
DK3242948T3
(da)
|
2015-01-06 |
2022-03-07 |
Dsm Ip Assets Bv |
Crispr-cas-system til en yarrowia-værtscelle
|
|
CN104593422A
(zh)
|
2015-01-08 |
2015-05-06 |
中国农业大学 |
一种抗蓝耳病克隆猪的制备方法
|
|
US20180155708A1
(en)
|
2015-01-08 |
2018-06-07 |
President And Fellows Of Harvard College |
Split Cas9 Proteins
|
|
EP3242938B1
(en)
|
2015-01-09 |
2020-01-08 |
Bio-Rad Laboratories, Inc. |
Detection of genome editing
|
|
CA2971626A1
(en)
|
2015-01-12 |
2016-07-21 |
Massachusetts Institute Of Technology |
Gene editing through microfluidic delivery
|
|
EP3245232B1
(en)
|
2015-01-12 |
2021-04-21 |
The Regents of The University of California |
Heterodimeric cas9 and methods of use thereof
|
|
WO2016112963A1
(en)
|
2015-01-13 |
2016-07-21 |
Riboxx Gmbh |
Delivery of biomolecules into cells
|
|
PL3244909T3
(pl)
|
2015-01-14 |
2020-04-30 |
Université D'aix-Marseille |
Inhibitory proteasomu do leczenia zaburzenia związanego z nagromadzeniem nieuszkodzonego, nieprawidłowego białka lub raka
|
|
MA41349A
(fr)
|
2015-01-14 |
2017-11-21 |
Univ Temple |
Éradication de l'herpès simplex de type i et d'autres virus de l'herpès associés guidée par arn
|
|
WO2016115326A1
(en)
|
2015-01-15 |
2016-07-21 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods for modulating genome editing
|
|
CN104611370A
(zh)
|
2015-01-16 |
2015-05-13 |
深圳市科晖瑞生物医药有限公司 |
一种剔除β2-微球蛋白基因片段的方法
|
|
EP3253879A4
(en)
|
2015-01-19 |
2018-06-20 |
Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences |
A method for precise modification of plant via transient gene expression
|
|
CN104725626B
(zh)
|
2015-01-22 |
2016-06-29 |
漳州亚邦化学有限公司 |
一种适用于人造石英石的不饱和树脂的制备方法
|
|
CN105821072A
(zh)
|
2015-01-23 |
2016-08-03 |
深圳华大基因研究院 |
用于DNA组装的CRISPR-Cas9系统及DNA组装方法
|
|
US20180023139A1
(en)
|
2015-01-26 |
2018-01-25 |
Cold Spring Harbor Laboratory |
Methods of identifying essential protein domains
|
|
US10059940B2
(en)
|
2015-01-27 |
2018-08-28 |
Minghong Zhong |
Chemically ligated RNAs for CRISPR/Cas9-lgRNA complexes as antiviral therapeutic agents
|
|
CN104561095B
(zh)
|
2015-01-27 |
2017-08-22 |
深圳市国创纳米抗体技术有限公司 |
一种能够生产人神经生长因子的转基因小鼠的制备方法
|
|
RU2713328C2
(ru)
|
2015-01-28 |
2020-02-04 |
Пайонир Хай-Бред Интернэшнл, Инк. |
Гибридные днк/рнк-полинуклеотиды crispr и способы применения
|
|
US11180792B2
(en)
|
2015-01-28 |
2021-11-23 |
The Regents Of The University Of California |
Methods and compositions for labeling a single-stranded target nucleic acid
|
|
BR112017016045A2
(pt)
|
2015-01-29 |
2018-04-03 |
Meiogenix |
método para induzir recombinações meióticas endereçadas em uma célula eucariótica, proteína de fusão, ácido nucleico, cassete de expressão ou um vetor, célula hospedeira, método para gerar variantes de um organismo eucariótico, método para identificar ou localizar as informações genéticas, kit, e, uso de um kit
|
|
CN107429254B
(zh)
|
2015-01-30 |
2021-10-15 |
加利福尼亚大学董事会 |
原代造血细胞中的蛋白递送
|
|
AU2016215454B2
(en)
|
2015-02-02 |
2022-05-19 |
MeiraGTx Gene Regulation Limited |
Regulation of gene expression by aptamer-mediated modulation of alternative splicing
|
|
CN104593418A
(zh)
|
2015-02-06 |
2015-05-06 |
中国医学科学院医学实验动物研究所 |
一种人源化大鼠药物评价动物模型建立的方法
|
|
EP3256487A4
(en)
|
2015-02-09 |
2018-07-18 |
Duke University |
Compositions and methods for epigenome editing
|
|
KR101584933B1
(ko)
|
2015-02-10 |
2016-01-13 |
성균관대학교산학협력단 |
항생제 내성 억제용 재조합 벡터 및 이의 용도
|
|
WO2016130697A1
(en)
|
2015-02-11 |
2016-08-18 |
Memorial Sloan Kettering Cancer Center |
Methods and kits for generating vectors that co-express multiple target molecules
|
|
CN104928321B
(zh)
|
2015-02-12 |
2018-06-01 |
中国科学院西北高原生物研究所 |
一种由Crispr/Cas9诱导的鳞片缺失斑马鱼模式及建立方法
|
|
CN104726494B
(zh)
|
2015-02-12 |
2018-10-23 |
中国人民解放军第二军医大学 |
CRISPR-Cas9技术构建染色体易位干细胞及动物模型的方法
|
|
WO2016131009A1
(en)
|
2015-02-13 |
2016-08-18 |
University Of Massachusetts |
Compositions and methods for transient delivery of nucleases
|
|
US20160244784A1
(en)
|
2015-02-15 |
2016-08-25 |
Massachusetts Institute Of Technology |
Population-Hastened Assembly Genetic Engineering
|
|
WO2016132122A1
(en)
|
2015-02-17 |
2016-08-25 |
University Of Edinburgh |
Assay construct
|
|
WO2016133165A1
(ja)
|
2015-02-19 |
2016-08-25 |
国立大学法人徳島大学 |
Cas9 mRNAを哺乳動物の受精卵にエレクトロポレーションにより導入する方法
|
|
US20180030438A1
(en)
|
2015-02-23 |
2018-02-01 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
|
US20180245073A1
(en)
|
2015-02-23 |
2018-08-30 |
Voyager Therapeutics, Inc. |
Regulatable expression using adeno-associated virus (aav)
|
|
US12129471B2
(en)
|
2015-02-23 |
2024-10-29 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of human genetic diseases including hemoglobinopathies
|
|
BR112017018327A2
(pt)
|
2015-02-25 |
2018-04-17 |
Pioneer Hi-Bred International, Inc. |
método para a expressão regulada de um complexo, planta ou célula vegetal, semente, método para modificação de uma sequência, método para alteração da expressão de pelo menos um polinucleotídeo
|
|
KR20160103953A
(ko)
|
2015-02-25 |
2016-09-02 |
연세대학교 산학협력단 |
Crispr 시스템을 이용한 다중 위치 염기서열의 동시 포획 방법
|
|
WO2016135507A1
(en)
|
2015-02-27 |
2016-09-01 |
University Of Edinburgh |
Nucleic acid editing systems
|
|
CN104805099B
(zh)
|
2015-03-02 |
2018-04-13 |
中国人民解放军第二军医大学 |
一种安全编码Cas9蛋白的核酸分子及其表达载体
|
|
EP3858990A1
(en)
|
2015-03-03 |
2021-08-04 |
The General Hospital Corporation |
Engineered crispr-cas9 nucleases with altered pam specificity
|
|
CN104651401B
(zh)
|
2015-03-05 |
2019-03-08 |
东华大学 |
一种mir-505双等位基因敲除的方法
|
|
CN104673816A
(zh)
|
2015-03-05 |
2015-06-03 |
广东医学院 |
一种pCr-NHEJ载体及其构建方法及其用于细菌基因定点敲除的应用
|
|
EP3268044A2
(en)
|
2015-03-11 |
2018-01-17 |
The Broad Institute Inc. |
Prmt5 inhibitors for the treatment of cancer with reduced mtap activty
|
|
US20160264934A1
(en)
|
2015-03-11 |
2016-09-15 |
The General Hospital Corporation |
METHODS FOR MODULATING AND ASSAYING m6A IN STEM CELL POPULATIONS
|
|
EA201791991A1
(ru)
|
2015-03-12 |
2018-07-31 |
Институт Генетики И Биологии Развития Академии Наук Китая |
Способ улучшения способности противодействовать внедренным днк-содержащим вирусам растения
|
|
GB201504223D0
(en)
|
2015-03-12 |
2015-04-29 |
Genome Res Ltd |
Biallelic genetic modification
|
|
KR102004076B1
(ko)
|
2015-03-13 |
2019-07-25 |
더 잭슨 래보라토리 |
3-성분 crispr/cas 복합체 시스템 및 그 용도
|
|
CN106032540B
(zh)
|
2015-03-16 |
2019-10-25 |
中国科学院上海生命科学研究院 |
CRISPR/Cas9核酸内切酶体系的腺相关病毒载体构建及其用途
|
|
US12043835B2
(en)
|
2015-03-16 |
2024-07-23 |
Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences |
Method for making site-directed modification to plant genomes by using non-inheritable materials
|
|
CN113846144B
(zh)
|
2015-03-17 |
2023-09-26 |
生物辐射实验室股份有限公司 |
检测基因组编辑
|
|
WO2016149484A2
(en)
|
2015-03-17 |
2016-09-22 |
Temple University Of The Commonwealth System Of Higher Education |
Compositions and methods for specific reactivation of hiv latent reservoir
|
|
EP3271461A1
(en)
|
2015-03-20 |
2018-01-24 |
Danmarks Tekniske Universitet |
Crispr/cas9 based engineering of actinomycetal genomes
|
|
MA41382A
(fr)
|
2015-03-20 |
2017-11-28 |
Univ Temple |
Édition génique basée sur le système crispr/endonucléase à induction par tat
|
|
CN104726449A
(zh)
|
2015-03-23 |
2015-06-24 |
国家纳米科学中心 |
一种用于预防和/或治疗HIV的CRISPR-Cas9系统及其制备方法和用途
|
|
CN106148416B
(zh)
|
2015-03-24 |
2019-12-17 |
华东师范大学 |
Cyp基因敲除大鼠的培育方法及其肝微粒体的制备方法
|
|
EP3274454B1
(en)
|
2015-03-25 |
2021-08-25 |
Editas Medicine, Inc. |
Crispr/cas-related methods, compositions and components
|
|
EP3274453B1
(en)
|
2015-03-26 |
2021-01-27 |
Editas Medicine, Inc. |
Crispr/cas-mediated gene conversion
|
|
WO2016161004A1
(en)
|
2015-03-30 |
2016-10-06 |
The Board Of Regents Of The Nevada System Of Higher Educ. On Behalf Of The University Of Nevada, La |
Compositions comprising talens and methods of treating hiv
|
|
KR20250002825A
(ko)
|
2015-03-31 |
2025-01-07 |
소흠, 인코포레이티드 |
세포 또는 유기체의 게놈으로의 DNA 서열의 표적화 혼입을 위한 Cas 9 레트로바이러스 인테그라제 시스템 및 Cas 9 재조합효소 시스템
|
|
WO2016161380A1
(en)
|
2015-04-01 |
2016-10-06 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating duchenne muscular dystrophy and becker muscular dystrophy
|
|
EP3300507A4
(en)
|
2015-04-02 |
2019-03-13 |
Agenovir Corporation |
GENERIC ADMINISTRATION AND COMPOSITIONS
|
|
EP4335918A3
(en)
|
2015-04-03 |
2024-04-17 |
Dana-Farber Cancer Institute, Inc. |
Composition and methods of genome editing of b-cells
|
|
US20170166928A1
(en)
|
2015-04-03 |
2017-06-15 |
Whitehead Institute For Biomedical Research |
Compositions And Methods For Genetically Modifying Yeast
|
|
CN106434737A
(zh)
|
2015-04-03 |
2017-02-22 |
内蒙古中科正标生物科技有限责任公司 |
基于CRISPR/Cas9技术的单子叶植物基因敲除载体及其应用
|
|
CN114231527A
(zh)
|
2015-04-06 |
2022-03-25 |
里兰斯坦福初级大学理事会 |
用于crispr/cas介导的基因调控的化学修饰的引导rna
|
|
WO2016164797A1
(en)
|
2015-04-08 |
2016-10-13 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Activatable crispr/cas9 for spatial and temporal control of genome editing
|
|
JP6892642B2
(ja)
|
2015-04-13 |
2021-06-23 |
国立大学法人 東京大学 |
光依存的に又は薬物存在下でヌクレアーゼ活性若しくはニッカーゼ活性を示す、又は標的遺伝子の発現を抑制若しくは活性化するポリペプチドのセット
|
|
US10155938B2
(en)
|
2015-04-14 |
2018-12-18 |
City Of Hope |
Coexpression of CAS9 and TREX2 for targeted mutagenesis
|
|
GB201506509D0
(en)
|
2015-04-16 |
2015-06-03 |
Univ Wageningen |
Nuclease-mediated genome editing
|
|
WO2016168631A1
(en)
|
2015-04-17 |
2016-10-20 |
President And Fellows Of Harvard College |
Vector-based mutagenesis system
|
|
EP3286322A1
(en)
|
2015-04-21 |
2018-02-28 |
Novartis AG |
Rna-guided gene editing system and uses thereof
|
|
CN104762321A
(zh)
|
2015-04-22 |
2015-07-08 |
东北林业大学 |
基于CRISPR/Cas9系统靶向敲除KHV基因的敲除载体构建方法及其crRNA原件
|
|
CN104805118A
(zh)
|
2015-04-22 |
2015-07-29 |
扬州大学 |
一种苏禽黄鸡胚胎干细胞特定基因进行靶向敲除方法
|
|
WO2016172359A2
(en)
|
2015-04-24 |
2016-10-27 |
The Regents Of The University Of California |
Systems for detecting, monitoring or treating diseases or conditions using engineered cells and methods for making and using them
|
|
US11268158B2
(en)
|
2015-04-24 |
2022-03-08 |
St. Jude Children's Research Hospital, Inc. |
Assay for safety assessment of therapeutic genetic manipulations, gene therapy vectors and compounds
|
|
WO2016172727A1
(en)
|
2015-04-24 |
2016-10-27 |
Editas Medicine, Inc. |
Evaluation of cas9 molecule/guide rna molecule complexes
|
|
WO2016176191A1
(en)
|
2015-04-27 |
2016-11-03 |
The Trustees Of The University Of Pennsylvania |
Dual aav vector system for crispr/cas9 mediated correction of human disease
|
|
US11104897B2
(en)
|
2015-04-27 |
2021-08-31 |
Genethon |
Compositions and methods for the treatment of nucleotide repeat expansion disorders
|
|
EP3087974A1
(en)
|
2015-04-29 |
2016-11-02 |
Rodos BioTarget GmbH |
Targeted nanocarriers for targeted drug delivery of gene therapeutics
|
|
US20190002920A1
(en)
|
2015-04-30 |
2019-01-03 |
The Brigham And Women's Hospital, Inc. |
Methods and kits for cloning-free genome editing
|
|
PT3289080T
(pt)
|
2015-04-30 |
2021-11-19 |
Univ Columbia |
Terapia genética para doenças autossómicas dominantes
|
|
DK3289076T3
(da)
|
2015-05-01 |
2022-01-17 |
Prec Biosciences Inc |
Præcis sletning af kromosomale sekvenser in vivo
|
|
US20160346359A1
(en)
|
2015-05-01 |
2016-12-01 |
Spark Therapeutics, Inc. |
Adeno-associated Virus-Mediated CRISPR-Cas9 Treatment of Ocular Disease
|
|
CN104894068A
(zh)
|
2015-05-04 |
2015-09-09 |
南京凯地生物科技有限公司 |
一种利用CRISPR/Cas9制备CAR-T细胞的方法
|
|
WO2016178207A1
(en)
|
2015-05-04 |
2016-11-10 |
Ramot At Tel-Aviv University Ltd. |
Methods and kits for fragmenting dna
|
|
EP3903586A1
(en)
|
2015-05-06 |
2021-11-03 |
Snipr Technologies Limited |
Altering microbial populations & modifying microbiota
|
|
GB2531454A
(en)
|
2016-01-10 |
2016-04-20 |
Snipr Technologies Ltd |
Recombinogenic nucleic acid strands in situ
|
|
EP3763814A1
(en)
|
2015-05-08 |
2021-01-13 |
The Children's Medical Center Corporation |
Targeting bcl11a enhancer functional regions for fetal hemoglobin reinduction
|
|
WO2016182893A1
(en)
|
2015-05-08 |
2016-11-17 |
Teh Broad Institute Inc. |
Functional genomics using crispr-cas systems for saturating mutagenesis of non-coding elements, compositions, methods, libraries and applications thereof
|
|
EP3294896A1
(en)
|
2015-05-11 |
2018-03-21 |
Editas Medicine, Inc. |
Optimized crispr/cas9 systems and methods for gene editing in stem cells
|
|
CA2985615A1
(en)
|
2015-05-11 |
2016-11-17 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating hiv infection and aids
|
|
SG10202112057QA
(en)
|
2015-05-12 |
2021-12-30 |
Sangamo Therapeutics Inc |
Nuclease-mediated regulation of gene expression
|
|
KR101785847B1
(ko)
|
2015-05-12 |
2017-10-17 |
연세대학교 산학협력단 |
선형 이중가닥 DNA를 활용한 CRISPR/Cas9 시스템을 이용한 표적 유전체 교정
|
|
CN105886498A
(zh)
|
2015-05-13 |
2016-08-24 |
沈志荣 |
CRISPR-Cas9特异性敲除人PCSK9基因的方法以及用于特异性靶向PCSK9基因的sgRNA
|
|
WO2016183402A2
(en)
|
2015-05-13 |
2016-11-17 |
President And Fellows Of Harvard College |
Methods of making and using guide rna for use with cas9 systems
|
|
US20180119174A1
(en)
|
2015-05-13 |
2018-05-03 |
Seattle Children's Hospita (dba Seattle Children's Research Institute |
Enhancing endonuclease based gene editing in primary cells
|
|
US11267899B2
(en)
|
2015-05-13 |
2022-03-08 |
Zumutor Biologics Inc. |
Afucosylated protein, cell expressing said protein and associated methods
|
|
CN107614680A
(zh)
|
2015-05-14 |
2018-01-19 |
南加利福尼亚大学 |
利用重组核酸内切酶系统的最佳化基因编辑
|
|
US20180291372A1
(en)
|
2015-05-14 |
2018-10-11 |
Massachusetts Institute Of Technology |
Self-targeting genome editing system
|
|
MX2017014560A
(es)
|
2015-05-15 |
2018-03-01 |
Pioneer Hi Bred Int |
Caracterizacion rapida de sistemas de endonucleasa cas, secuencias pam y elementos arn de guia.
|
|
WO2016186745A1
(en)
|
2015-05-15 |
2016-11-24 |
Ge Healthcare Dharmacon, Inc. |
Synthetic single guide rna for cas9-mediated gene editing
|
|
CN114657180A
(zh)
|
2015-05-16 |
2022-06-24 |
建新公司 |
深内含子突变的基因编辑
|
|
CN104846010B
(zh)
|
2015-05-18 |
2018-07-06 |
安徽省农业科学院水稻研究所 |
一种删除转基因水稻筛选标记基因的方法
|
|
WO2016185411A1
(en)
|
2015-05-18 |
2016-11-24 |
King Abdullah University Of Science And Technology |
Method of inhibiting plant virus pathogen infections by crispr/cas9-mediated interference
|
|
EP3095870A1
(en)
|
2015-05-19 |
2016-11-23 |
Kws Saat Se |
Methods for the in planta transformation of plants and manufacturing processes and products based and obtainable therefrom
|
|
CN106011104B
(zh)
|
2015-05-21 |
2019-09-27 |
清华大学 |
利用拆分Cas系统进行基因编辑和表达调控方法
|
|
WO2016187904A1
(zh)
|
2015-05-22 |
2016-12-01 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪CMAH基因的方法及用于特异性靶向CMAH基因的sgRNA
|
|
US20160340622A1
(en)
|
2015-05-22 |
2016-11-24 |
Nabil Radi Abdou |
Bar Soap Anchoring Core
|
|
CN105518135B
(zh)
|
2015-05-22 |
2020-11-24 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪CMAH基因的方法及用于特异性靶向CMAH基因的sgRNA
|
|
WO2016187717A1
(en)
|
2015-05-26 |
2016-12-01 |
Exerkine Corporation |
Exosomes useful for genome editing
|
|
US20180148711A1
(en)
|
2015-05-28 |
2018-05-31 |
Coda Biotherapeutics, Inc. |
Genome editing vectors
|
|
CN104894075B
(zh)
|
2015-05-28 |
2019-08-06 |
华中农业大学 |
CRISPR/Cas9和Cre/lox系统编辑伪狂犬病毒基因组制备疫苗方法和应用
|
|
CN105624146B
(zh)
|
2015-05-28 |
2019-02-15 |
中国科学院微生物研究所 |
基于CRISPR/Cas9和酿酒酵母细胞内源的同源重组的分子克隆方法
|
|
GB2542653A
(en)
|
2015-05-29 |
2017-03-29 |
Agenovir Corp |
Methods and compositions for treating cells for transplant
|
|
EP3325620A4
(en)
|
2015-05-29 |
2019-06-26 |
Agenovir Corporation |
ANTIVIRAL PROCEDURES AND COMPOSITIONS
|
|
US10117911B2
(en)
|
2015-05-29 |
2018-11-06 |
Agenovir Corporation |
Compositions and methods to treat herpes simplex virus infections
|
|
WO2016196361A1
(en)
|
2015-05-29 |
2016-12-08 |
North Carolina State University |
Methods for screening bacteria, archaea, algae, and yeast using crispr nucleic acids
|
|
WO2016196499A1
(en)
|
2015-05-29 |
2016-12-08 |
Clark Atlanta University |
Human cell lines mutant for zic2
|
|
GB2543873A
(en)
|
2015-05-29 |
2017-05-03 |
Agenovir Corp |
Compositions and methods for cell targeted HPV treatment
|
|
JP2018516983A
(ja)
|
2015-05-29 |
2018-06-28 |
アジェノビア コーポレーション |
ウイルス感染を処置するための組成物および方法
|
|
US20160346362A1
(en)
|
2015-05-29 |
2016-12-01 |
Agenovir Corporation |
Methods and compositions for treating cytomegalovirus infections
|
|
EP3303403A4
(en)
|
2015-06-01 |
2019-01-16 |
The Hospital for Sick Children |
RELEASE OF STRUCTURELY DIFFERENT POLYPEPTIDES IN MAMMALIAN CELLS BY MEANS OF BACTERIAL TOXIN
|
|
SG10201914137YA
(en)
|
2015-06-01 |
2020-02-27 |
Univ Temple |
Methods and compositions for rna-guided treatment of hiv infection
|
|
CN105112445B
(zh)
|
2015-06-02 |
2018-08-10 |
广州辉园苑医药科技有限公司 |
一种基于CRISPR-Cas9基因敲除技术的miR-205基因敲除试剂盒
|
|
EP3303585A4
(en)
|
2015-06-03 |
2018-10-31 |
Board of Regents of the University of Nebraska |
Dna editing using single-stranded dna
|
|
US10392607B2
(en)
|
2015-06-03 |
2019-08-27 |
The Regents Of The University Of California |
Cas9 variants and methods of use thereof
|
|
US20180245074A1
(en)
|
2015-06-04 |
2018-08-30 |
Protiva Biotherapeutics, Inc. |
Treating hepatitis b virus infection using crispr
|
|
US10626393B2
(en)
|
2015-06-04 |
2020-04-21 |
Arbutus Biopharma Corporation |
Delivering CRISPR therapeutics with lipid nanoparticles
|
|
EP3334823B1
(en)
|
2015-06-05 |
2024-05-22 |
The Regents of The University of California |
Method and kit for generating crispr/cas guide rnas
|
|
CN105039339B
(zh)
|
2015-06-05 |
2017-12-19 |
新疆畜牧科学院生物技术研究所 |
一种以RNA介导的特异性敲除绵羊FecB基因的方法及其专用sgRNA
|
|
JP7396783B2
(ja)
|
2015-06-09 |
2023-12-12 |
エディタス・メディシン、インコーポレイテッド |
移植を改善するためのcrispr/cas関連方法および組成物
|
|
JP7085841B2
(ja)
|
2015-06-10 |
2022-06-17 |
フイルメニツヒ ソシエテ アノニム |
ムスク化合物の同定方法
|
|
CA2987078A1
(en)
|
2015-06-10 |
2016-12-15 |
Firmenich Sa |
Cell lines for screening odorant and aroma receptors
|
|
US20160362667A1
(en)
|
2015-06-10 |
2016-12-15 |
Caribou Biosciences, Inc. |
CRISPR-Cas Compositions and Methods
|
|
WO2016198500A1
(en)
|
2015-06-10 |
2016-12-15 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for rna-guided treatment of human cytomegalovirus (hcmv) infection
|
|
WO2016197354A1
(zh)
|
2015-06-11 |
2016-12-15 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪PDX1基因的方法及用于特异性靶向PDX1基因的sgRNA
|
|
WO2016197362A1
(zh)
|
2015-06-11 |
2016-12-15 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪vWF基因的方法及用于特异性靶向vWF基因的sgRNA
|
|
WO2016197357A1
(zh)
|
2015-06-11 |
2016-12-15 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪SLA-3基因的方法及用于特异性靶向SLA-3基因的sgRNA
|
|
WO2016197356A1
(zh)
|
2015-06-11 |
2016-12-15 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪SLA-2基因的方法及用于特异性靶向SLA-2基因的sgRNA
|
|
WO2016197361A1
(zh)
|
2015-06-11 |
2016-12-15 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪GGTA1基因的方法及用于特异性靶向GGTA1基因的sgRNA
|
|
WO2016197360A1
(zh)
|
2015-06-11 |
2016-12-15 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪GFRA1基因的方法及用于特异性靶向GFRA1基因的sgRNA
|
|
WO2016197359A1
(zh)
|
2015-06-11 |
2016-12-15 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪SLA-1基因的方法及用于特异性靶向SLA-1基因的sgRNA
|
|
CN105518139B
(zh)
|
2015-06-11 |
2021-02-02 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪FGL2基因的方法及用于特异性靶向FGL2基因的sgRNA
|
|
CN105518137B
(zh)
|
2015-06-11 |
2021-04-30 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪SALL1基因的方法及用于特异性靶向SALL1基因的sgRNA
|
|
EP3307888A1
(en)
|
2015-06-12 |
2018-04-18 |
Erasmus University Medical Center Rotterdam |
New crispr assays
|
|
GB201510296D0
(en)
|
2015-06-12 |
2015-07-29 |
Univ Wageningen |
Thermostable CAS9 nucleases
|
|
US20180142222A1
(en)
|
2015-06-12 |
2018-05-24 |
The Regents Of The University Of California |
Reporter cas9 variants and methods of use thereof
|
|
EP4299754A3
(en)
|
2015-06-15 |
2024-03-20 |
North Carolina State University |
Methods and compositions for efficient delivery of nucleic acids and rna-based antimicrobials
|
|
EP3310932B1
(en)
|
2015-06-17 |
2023-08-30 |
The UAB Research Foundation |
Crispr/cas9 complex for genomic editing
|
|
EP3310931B1
(en)
|
2015-06-17 |
2021-11-17 |
The UAB Research Foundation |
Crispr/cas9 complex for introducing a functional polypeptide into cells of blood cell lineage
|
|
WO2016205623A1
(en)
|
2015-06-17 |
2016-12-22 |
North Carolina State University |
Methods and compositions for genome editing in bacteria using crispr-cas9 systems
|
|
WO2016205728A1
(en)
|
2015-06-17 |
2016-12-22 |
Massachusetts Institute Of Technology |
Crispr mediated recording of cellular events
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
RU2752834C2
(ru)
|
2015-06-18 |
2021-08-09 |
Те Брод Инститьют, Инк. |
Мутации фермента crispr, уменьшающие нецелевые эффекты
|
|
WO2016205764A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
US9957501B2
(en)
|
2015-06-18 |
2018-05-01 |
Sangamo Therapeutics, Inc. |
Nuclease-mediated regulation of gene expression
|
|
US10954513B2
(en)
|
2015-06-18 |
2021-03-23 |
University Of Utah Research Foundation |
RNA-guided transcriptional regulation and methods of using the same for the treatment of back pain
|
|
AU2016279062A1
(en)
|
2015-06-18 |
2019-03-28 |
Omar O. Abudayyeh |
Novel CRISPR enzymes and systems
|
|
WO2016205745A2
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Cell sorting
|
|
GB201511376D0
(en)
|
2015-06-29 |
2015-08-12 |
Ecolab Usa Inc |
Process for the treatment of produced water from chemical enhanced oil recovery
|
|
EP3313989B1
(en)
|
2015-06-29 |
2024-12-25 |
Ionis Pharmaceuticals, Inc. |
Modified crispr rna and modified single crispr rna and uses thereof
|
|
US11279928B2
(en)
|
2015-06-29 |
2022-03-22 |
Massachusetts Institute Of Technology |
Compositions comprising nucleic acids and methods of using the same
|
|
EP3317399B1
(en)
|
2015-06-30 |
2024-06-26 |
Cellectis |
Methods for improving functionality in nk cell by gene inactivation using specific endonuclease
|
|
US20200010854A1
(en)
|
2015-07-02 |
2020-01-09 |
The Johns Hopkins University |
Crispr/cas9-based treatments
|
|
WO2017005807A1
(en)
|
2015-07-06 |
2017-01-12 |
Dsm Ip Assets B.V. |
Guide rna assembly vector
|
|
US20170009242A1
(en)
|
2015-07-06 |
2017-01-12 |
Whitehead Institute For Biomedical Research |
CRISPR-Mediated Genome Engineering for Protein Depletion
|
|
CN105132451B
(zh)
|
2015-07-08 |
2019-07-23 |
电子科技大学 |
一种CRISPR/Cas9单一转录单元定向修饰骨架载体及其应用
|
|
US10450585B2
(en)
|
2015-07-13 |
2019-10-22 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
|
US20170014449A1
(en)
|
2015-07-13 |
2017-01-19 |
Elwha LLC, a limited liability company of the State of Delaware |
Site-specific epigenetic editing
|
|
WO2017009399A1
(en)
|
2015-07-13 |
2017-01-19 |
Institut Pasteur |
Improving sequence-specific antimicrobials by blocking dna repair
|
|
US11390865B2
(en)
|
2015-07-14 |
2022-07-19 |
Fukuoka University |
Method for introducing site-directed RNA mutation, target editing guide RNA used in the method and target RNA-target editing guide RNA complex
|
|
EP3322804B1
(en)
|
2015-07-15 |
2021-09-01 |
Rutgers, The State University of New Jersey |
Nuclease-independent targeted gene editing platform and uses thereof
|
|
MA42895A
(fr)
|
2015-07-15 |
2018-05-23 |
Juno Therapeutics Inc |
Cellules modifiées pour thérapie cellulaire adoptive
|
|
US20170020922A1
(en)
|
2015-07-16 |
2017-01-26 |
Batu Biologics Inc. |
Gene editing for immunological destruction of neoplasia
|
|
WO2017015015A1
(en)
|
2015-07-17 |
2017-01-26 |
Emory University |
Crispr-associated protein from francisella and uses related thereto
|
|
WO2017015101A1
(en)
|
2015-07-17 |
2017-01-26 |
University Of Washington |
Methods for maximizing the efficiency of targeted gene correction
|
|
EP3325018B1
(en)
|
2015-07-22 |
2025-01-15 |
Duke University |
High-throughput screening of regulatory element function with epigenome editing technologies
|
|
WO2017015545A1
(en)
|
2015-07-22 |
2017-01-26 |
President And Fellows Of Harvard College |
Evolution of site-specific recombinases
|
|
WO2017015567A1
(en)
|
2015-07-23 |
2017-01-26 |
Mayo Foundation For Medical Education And Research |
Editing mitochondrial dna
|
|
US20180360994A1
(en)
|
2015-07-25 |
2018-12-20 |
Habib Frost |
System, device and a method for providing a therapy or a cure for cancer and other pathological states
|
|
CN106399360A
(zh)
|
2015-07-27 |
2017-02-15 |
上海药明生物技术有限公司 |
基于crispr技术敲除fut8基因的方法
|
|
CN105063061B
(zh)
|
2015-07-28 |
2018-10-30 |
华南农业大学 |
一种水稻千粒重基因tgw6突变体及其制备方法与应用
|
|
EP3329001B1
(en)
|
2015-07-28 |
2021-09-22 |
Danisco US Inc. |
Genome editing systems and methods of use
|
|
CN106701808A
(zh)
|
2015-07-29 |
2017-05-24 |
深圳华大基因研究院 |
Dna聚合酶i缺陷型菌株及其构建方法
|
|
US10612011B2
(en)
|
2015-07-30 |
2020-04-07 |
President And Fellows Of Harvard College |
Evolution of TALENs
|
|
GB2595063B
(en)
|
2015-07-31 |
2022-03-09 |
Univ Minnesota |
Modified cells and methods of therapy
|
|
WO2017069829A2
(en)
|
2015-07-31 |
2017-04-27 |
The Trustees Of Columbia University In The City Of New York |
High-throughput strategy for dissecting mammalian genetic interactions
|
|
WO2017024047A1
(en)
|
2015-08-03 |
2017-02-09 |
Emendobio Inc. |
Compositions and methods for increasing nuclease induced recombination rate in cells
|
|
WO2017023974A1
(en)
|
2015-08-03 |
2017-02-09 |
President And Fellows Of Harvard College |
Cas9 genome editing and transcriptional regulation
|
|
CA2995036A1
(en)
|
2015-08-06 |
2017-02-09 |
Dana-Farber Cancer Institute, Inc. |
Tunable endogenous protein degradation
|
|
CN104962523B
(zh)
|
2015-08-07 |
2018-05-25 |
苏州大学 |
一种测定非同源末端连接修复活性的方法
|
|
US9580727B1
(en)
|
2015-08-07 |
2017-02-28 |
Caribou Biosciences, Inc. |
Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
|
|
EP3332014A4
(en)
|
2015-08-07 |
2019-01-23 |
Commonwealth Scientific and Industrial Research Organisation |
METHOD FOR PRODUCING ANIMAL WITH GENETIC GLAND CARBON MODIFICATION
|
|
EP3334442B1
(en)
|
2015-08-11 |
2024-12-18 |
Cellectis |
Cells for immunotherapy engineered for targeting cd38 antigen and for cd38 gene inactivation
|
|
CA2994883A1
(en)
|
2015-08-14 |
2017-02-23 |
Institute Of Genetics And Developmental Biology, Chinese Academy Of Scnces |
Method for obtaining glyphosate-resistant rice by site-directed nucleotide substitution
|
|
CN105255937A
(zh)
|
2015-08-14 |
2016-01-20 |
西北农林科技大学 |
一种真核细胞III型启动子表达CRISPR sgRNA的方法及其应用
|
|
US10538758B2
(en)
|
2015-08-19 |
2020-01-21 |
Arc Bio, Llc |
Capture of nucleic acids using a nucleic acid-guided nuclease-based system
|
|
CN105112519A
(zh)
|
2015-08-20 |
2015-12-02 |
郑州大学 |
一种基于crispr的大肠杆菌o157:h7菌株检测试剂盒及检测方法
|
|
US11339408B2
(en)
|
2015-08-20 |
2022-05-24 |
Applied Stemcell, Inc. |
Nuclease with enhanced efficiency of genome editing
|
|
CN105177126B
(zh)
|
2015-08-21 |
2018-12-04 |
东华大学 |
一种利用荧光pcr技术对小鼠的分型鉴定方法
|
|
ES2929110T3
(es)
|
2015-08-25 |
2022-11-24 |
Univ Duke |
Composiciones y métodos para mejorar la especificidad en ingeniería genética usando endonucleasas guiadas por ARN
|
|
CN106480083B
(zh)
|
2015-08-26 |
2021-12-14 |
中国科学院分子植物科学卓越创新中心 |
CRISPR/Cas9介导的大片段DNA拼接方法
|
|
JP6799586B2
(ja)
|
2015-08-28 |
2020-12-16 |
ザ ジェネラル ホスピタル コーポレイション |
遺伝子操作CRISPR−Cas9ヌクレアーゼ
|
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
CN105087620B
(zh)
|
2015-08-31 |
2017-12-29 |
中国农业大学 |
一种过表达猪共刺激受体4‑1bb载体及其应用
|
|
WO2017040511A1
(en)
|
2015-08-31 |
2017-03-09 |
Agilent Technologies, Inc. |
Compounds and methods for crispr/cas-based genome editing by homologous recombination
|
|
US20170058272A1
(en)
|
2015-08-31 |
2017-03-02 |
Caribou Biosciences, Inc. |
Directed nucleic acid repair
|
|
AU2016316027B2
(en)
|
2015-09-01 |
2022-04-07 |
Dana-Farber Cancer Institute Inc. |
Systems and methods for selection of gRNA targeting strands for Cas9 localization
|
|
US11390908B2
(en)
|
2015-09-02 |
2022-07-19 |
University Of Massachusetts |
Detection of gene loci with CRISPR arrayed repeats and/or polychromatic single guide ribonucleic acids
|
|
US20180251789A1
(en)
|
2015-09-04 |
2018-09-06 |
Massachusetts Institute Of Technology |
Multilayer genetic safety kill circuits based on single cas9 protein and multiple engineered grna in mammalian cells
|
|
CN105400810B
(zh)
|
2015-09-06 |
2019-05-07 |
吉林大学 |
采用敲除技术建立低磷性佝偻病模型的方法
|
|
CA3036409C
(en)
|
2015-09-08 |
2023-07-11 |
Erik J. Sontheimer |
Dnase h activity of neisseria meningitidis cas9
|
|
US10767173B2
(en)
|
2015-09-09 |
2020-09-08 |
National University Corporation Kobe University |
Method for converting genome sequence of gram-positive bacterium by specifically converting nucleic acid base of targeted DNA sequence, and molecular complex used in same
|
|
US20190024098A1
(en)
|
2015-09-09 |
2019-01-24 |
National University Corporation Kobe University |
Method for modifying genome sequence that specifically converts nucleobase of targeted dna sequence, and molecular complex used in said method
|
|
CA2998158A1
(en)
|
2015-09-10 |
2017-03-16 |
Youhealth Biotech, Limited |
Methods and compositions for the treatment of glaucoma
|
|
WO2017044776A1
(en)
|
2015-09-10 |
2017-03-16 |
Texas Tech University System |
Single-guide rna (sgrna) with improved knockout efficiency
|
|
CN105274144A
(zh)
|
2015-09-14 |
2016-01-27 |
徐又佳 |
通过CRISPR/Cas9技术得到敲除铁调素基因斑马鱼的制备方法
|
|
CN105210981B
(zh)
|
2015-09-15 |
2018-09-28 |
中国科学院生物物理研究所 |
建立可应用于人类疾病研究的雪貂模型的方法及其应用
|
|
US10109551B2
(en)
|
2015-09-15 |
2018-10-23 |
Intel Corporation |
Methods and apparatuses for determining a parameter of a die
|
|
US10301613B2
(en)
|
2015-09-15 |
2019-05-28 |
Arizona Board Of Regents On Behalf Of Arizona State University |
Targeted remodeling of prokaryotic genomes using CRISPR-nickases
|
|
CN105112422B
(zh)
|
2015-09-16 |
2019-11-08 |
中山大学 |
基因miR408和UCL在培育高产水稻中的应用
|
|
US11261439B2
(en)
|
2015-09-18 |
2022-03-01 |
President And Fellows Of Harvard College |
Methods of making guide RNA
|
|
CN105132427B
(zh)
|
2015-09-21 |
2019-01-08 |
新疆畜牧科学院生物技术研究所 |
一种以RNA介导的特异性敲除双基因获得基因编辑绵羊的方法及其专用sgRNA
|
|
CN108350454B
(zh)
|
2015-09-21 |
2022-05-10 |
阿克丘勒斯治疗公司 |
等位基因选择性基因编辑及其用途
|
|
US20180237800A1
(en)
|
2015-09-21 |
2018-08-23 |
The Regents Of The University Of California |
Compositions and methods for target nucleic acid modification
|
|
CA2998500A1
(en)
|
2015-09-23 |
2017-03-30 |
Sangamo Therapeutics, Inc. |
Htt repressors and uses thereof
|
|
WO2017053762A1
(en)
|
2015-09-24 |
2017-03-30 |
Sigma-Aldrich Co. Llc |
Methods and reagents for molecular proximity detection using rna-guided nucleic acid binding proteins
|
|
EP3353297A1
(en)
|
2015-09-24 |
2018-08-01 |
Crispr Therapeutics AG |
Novel family of rna-programmable endonucleases and their uses in genome editing and other applications
|
|
WO2017053879A1
(en)
|
2015-09-24 |
2017-03-30 |
Editas Medicine, Inc. |
Use of exonucleases to improve crispr/cas-mediated genome editing
|
|
WO2017053729A1
(en)
|
2015-09-25 |
2017-03-30 |
The Board Of Trustees Of The Leland Stanford Junior University |
Nuclease-mediated genome editing of primary cells and enrichment thereof
|
|
KR101795999B1
(ko)
|
2015-09-25 |
2017-11-09 |
전남대학교산학협력단 |
Crispr/cas9 시스템을 이용한 베타2-마이크로글로불린 유전자 제거용 시발체
|
|
KR101745863B1
(ko)
|
2015-09-25 |
2017-06-12 |
전남대학교산학협력단 |
Crispr/cas9 시스템을 이용한 프로히비틴2 유전자 제거용 시발체
|
|
EP3353309A4
(en)
|
2015-09-25 |
2019-04-10 |
Tarveda Therapeutics, Inc. |
COMPOSITIONS AND METHOD FOR GENERIC EDITING
|
|
EP3147363B1
(en)
|
2015-09-26 |
2019-10-16 |
B.R.A.I.N. Ag |
Activation of taste receptor genes in mammalian cells using crispr-cas-9
|
|
US20190367910A1
(en)
|
2015-09-28 |
2019-12-05 |
Temple University - Of The Commonwealth System Of Higher Education |
Methods and compositions for rna-guided treatment of hiv infection
|
|
WO2017058796A1
(en)
|
2015-09-29 |
2017-04-06 |
Agenovir Corporation |
Antiviral fusion proteins and genes
|
|
CN105177038B
(zh)
|
2015-09-29 |
2018-08-24 |
中国科学院遗传与发育生物学研究所 |
一种高效定点编辑植物基因组的CRISPR/Cas9系统
|
|
AU2016332706A1
(en)
|
2015-09-29 |
2018-04-12 |
Agenovir Corporation |
Compositions and methods for latent viral transcription regulation
|
|
US20170088828A1
(en)
|
2015-09-29 |
2017-03-30 |
Agenovir Corporation |
Compositions and methods for treatment of latent viral infections
|
|
HK1258900A1
(zh)
|
2015-09-29 |
2019-11-22 |
埃吉诺维亚公司 |
递送方法和组合物
|
|
CN105331627B
(zh)
|
2015-09-30 |
2019-04-02 |
华中农业大学 |
一种利用内源CRISPR-Cas系统进行原核生物基因组编辑的方法
|
|
WO2017059241A1
(en)
|
2015-10-02 |
2017-04-06 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Lentiviral protein delivery system for rna-guided genome editing
|
|
AU2016336452B2
(en)
|
2015-10-06 |
2022-10-06 |
The Children's Hospital Of Philadelphia |
Compositions and methods for treating fragile X syndrome and related syndromes
|
|
WO2017062754A1
(en)
|
2015-10-07 |
2017-04-13 |
New York University |
Compositions and methods for enhancing crispr activity by polq inhibition
|
|
MX2018004263A
(es)
|
2015-10-08 |
2019-08-16 |
Harvard College |
Edición genómica multiplexada.
|
|
WO2017062886A1
(en)
|
2015-10-08 |
2017-04-13 |
Cellink Corporation |
Battery interconnects
|
|
US11473084B2
(en)
|
2015-10-09 |
2022-10-18 |
The Children's Hospital Of Philadelphia |
Compositions and methods for treating Huntington's disease and related disorders
|
|
EP3359644B1
(en)
|
2015-10-09 |
2024-05-29 |
Monsanto Technology LLC |
Novel rna-guided nucleases and uses thereof
|
|
US20180273979A1
(en)
|
2015-10-12 |
2018-09-27 |
E I Du Pont De Nemours And Company |
Protected dna templates for gene modification and increased homologous recombination in cells and methods of use
|
|
US11970710B2
(en)
|
2015-10-13 |
2024-04-30 |
Duke University |
Genome engineering with Type I CRISPR systems in eukaryotic cells
|
|
CN108367081A
(zh)
|
2015-10-14 |
2018-08-03 |
生命技术公司 |
核糖核蛋白转染剂
|
|
CN105400779A
(zh)
|
2015-10-15 |
2016-03-16 |
芜湖医诺生物技术有限公司 |
嗜热链球菌CRISPR-Cas9系统识别的人CCR5基因的靶序列和sgRNA及其应用
|
|
WO2017066781A1
(en)
|
2015-10-16 |
2017-04-20 |
Modernatx, Inc. |
Mrna cap analogs with modified phosphate linkage
|
|
EP3362104A4
(en)
|
2015-10-16 |
2019-03-27 |
Temple University - Of The Commonwealth System of Higher Education |
METHOD AND COMPOSITIONS USING CPF1 FOR RNA-GUIDED GEN EDITING
|
|
FR3042506B1
(fr)
|
2015-10-16 |
2018-11-30 |
IFP Energies Nouvelles |
Outil genetique de transformation de bacteries clostridium
|
|
WO2017064566A2
(en)
|
2015-10-16 |
2017-04-20 |
Astrazeneca Ab |
Inducible modification of a cell genome
|
|
WO2017070169A1
(en)
|
2015-10-19 |
2017-04-27 |
The Methodist Hospital |
Crispr-cas9 delivery to hard-to-transfect cells via membrane deformation
|
|
CN105331607A
(zh)
|
2015-10-19 |
2016-02-17 |
芜湖医诺生物技术有限公司 |
嗜热链球菌CRISPR-Cas9系统识别的人CCR5基因的靶序列和sgRNA及其应用
|
|
JP2018531024A
(ja)
|
2015-10-20 |
2018-10-25 |
パイオニア ハイ−ブレッド インターナショナル, イン |
マーカーフリーゲノム改変のための方法および組成物
|
|
CN105331608A
(zh)
|
2015-10-20 |
2016-02-17 |
芜湖医诺生物技术有限公司 |
脑膜炎双球菌CRISPR-Cas9系统识别的人CXCR4基因的靶序列和sgRNA及其应用
|
|
CN105316324A
(zh)
|
2015-10-20 |
2016-02-10 |
芜湖医诺生物技术有限公司 |
嗜热链球菌CRISPR-Cas9系统识别的人CXCR4基因的靶序列和sgRNA及其应用
|
|
CN105316337A
(zh)
|
2015-10-20 |
2016-02-10 |
芜湖医诺生物技术有限公司 |
嗜热链球菌CRISPR-Cas9系统识别的人CXCR4基因的靶序列和sgRNA及其应用
|
|
CN105331609A
(zh)
|
2015-10-20 |
2016-02-17 |
芜湖医诺生物技术有限公司 |
脑膜炎双球菌CRISPR-Cas9系统识别的人CCR5基因的靶序列和sgRNA及其应用
|
|
JP7059179B2
(ja)
|
2015-10-20 |
2022-04-25 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
遺伝子操作のための方法及び製品
|
|
CA3001351A1
(en)
|
2015-10-21 |
2017-04-27 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating hepatitis b virus
|
|
CN105219799A
(zh)
|
2015-10-22 |
2016-01-06 |
天津吉诺沃生物科技有限公司 |
一种基于CRISPR/Cas系统的多年生黑麦草的育种方法
|
|
KR20250021623A
(ko)
|
2015-10-22 |
2025-02-13 |
더 브로드 인스티튜트, 인코퍼레이티드 |
타입 vi-b crispr 효소 및 시스템
|
|
CA3002827A1
(en)
|
2015-10-23 |
2017-04-27 |
President And Fellows Of Harvard College |
Nucleobase editors and uses thereof
|
|
EP3159407A1
(en)
|
2015-10-23 |
2017-04-26 |
Silence Therapeutics (London) Ltd |
Guide rnas, methods and uses
|
|
DK3350327T3
(en)
|
2015-10-23 |
2019-01-21 |
Caribou Biosciences Inc |
CONSTRUCTED CRISPR CLASS-2-NUCLEIC ACID TARGETING-NUCLEIC ACID
|
|
TW201715041A
(zh)
|
2015-10-26 |
2017-05-01 |
國立清華大學 |
細菌基因編輯方法
|
|
US9988637B2
(en)
|
2015-10-26 |
2018-06-05 |
National Tsing Hua Univeristy |
Cas9 plasmid, genome editing system and method of Escherichia coli
|
|
US10280411B2
(en)
|
2015-10-27 |
2019-05-07 |
Pacific Biosciences of California, In.c |
Methods, systems, and reagents for direct RNA sequencing
|
|
AU2016344135A1
(en)
|
2015-10-27 |
2018-06-14 |
Board Of Regents, The University Of Texas System |
Engineering of humanized car T-cells and platelets by genetic complementation
|
|
US20180230489A1
(en)
|
2015-10-28 |
2018-08-16 |
Voyager Therapeutics, Inc. |
Regulatable expression using adeno-associated virus (aav)
|
|
EP4632068A2
(en)
|
2015-10-28 |
2025-10-15 |
Vertex Pharmaceuticals Inc. |
Materials and methods for treatment of duchenne muscular dystrophy
|
|
PE20181206A1
(es)
|
2015-10-28 |
2018-07-23 |
Sangamo Therapeutics Inc |
Construcciones especificas del higado, casetes de expresion del factor viii y metodos de uso de estos
|
|
CA3001711A1
(en)
|
2015-10-30 |
2017-05-04 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating herpes simplex virus
|
|
WO2017074962A1
(en)
|
2015-10-30 |
2017-05-04 |
Brandeis University |
Modified cas9 compositions and methods of use
|
|
CN105238806B
(zh)
|
2015-11-02 |
2018-11-27 |
中国科学院天津工业生物技术研究所 |
一种用于微生物的CRISPR/Cas9基因编辑载体的构建及其应用
|
|
CN105316327B
(zh)
|
2015-11-03 |
2019-01-29 |
中国农业科学院作物科学研究所 |
小麦TaAGO4a基因CRISPR/Cas9载体及其应用
|
|
SG10202107602XA
(en)
|
2015-11-04 |
2021-08-30 |
Univ Pennsylvania |
Methods and compositions for gene editing in hematopoietic stem cells
|
|
CN115806940A
(zh)
|
2015-11-04 |
2023-03-17 |
菲特治疗公司 |
多能细胞的基因组工程改造
|
|
WO2017079428A1
(en)
|
2015-11-04 |
2017-05-11 |
President And Fellows Of Harvard College |
Site specific germline modification
|
|
CA3004171A1
(en)
|
2015-11-05 |
2017-05-11 |
Fundacion Instituto De Investigacion Sanitaria Fundacion Jimenez Diaz |
Process of gene-editing of cells isolated from a subject suffering from a metabolic disease affecting the erythroid lineage, cells obtained by said process and uses thereof
|
|
GB2544270A
(en)
|
2015-11-05 |
2017-05-17 |
Fundació Centre De Regulació Genòmica |
Nucleic acids, peptides and methods
|
|
WO2017078751A1
(en)
|
2015-11-06 |
2017-05-11 |
The Methodist Hospital |
Micoluidic cell deomailiy assay for enabling rapid and efficient kinase screening via the crispr-cas9 system
|
|
WO2017079724A1
(en)
|
2015-11-06 |
2017-05-11 |
The Jackson Laboratory |
Large genomic dna knock-in and uses thereof
|
|
WO2017081097A1
(en)
|
2015-11-09 |
2017-05-18 |
Ifom Fondazione Istituto Firc Di Oncologia Molecolare |
Crispr-cas sgrna library
|
|
WO2017083722A1
(en)
|
2015-11-11 |
2017-05-18 |
Greenberg Kenneth P |
Crispr compositions and methods of using the same for gene therapy
|
|
EP3374501B1
(en)
|
2015-11-11 |
2023-07-12 |
Lonza Ltd |
Crispr-associated (cas) proteins with reduced immunogenicity
|
|
EP3373979A1
(en)
|
2015-11-12 |
2018-09-19 |
Pfizer Inc |
Tissue-specific genome engineering using crispr-cas9
|
|
KR101885901B1
(ko)
|
2015-11-13 |
2018-08-07 |
기초과학연구원 |
5' 말단의 인산기가 제거된 rna를 포함하는 리보핵산단백질 전달용 조성물
|
|
WO2017083766A1
(en)
|
2015-11-13 |
2017-05-18 |
Massachusetts Institute Of Technology |
High-throughput crispr-based library screening
|
|
US20170191047A1
(en)
|
2015-11-13 |
2017-07-06 |
University Of Georgia Research Foundation, Inc. |
Adenosine-specific rnase and methods of use
|
|
EA201891192A1
(ru)
|
2015-11-16 |
2019-01-31 |
Рисёрч Инститьют Эт Нейшнвайд Чилдрен'С Хоспитал |
Средства и способы лечения миопатий, связанных с титином, и других титинопатий
|
|
CN106893739A
(zh)
|
2015-11-17 |
2017-06-27 |
香港中文大学 |
用于靶向基因操作的新方法和系统
|
|
EP3380613B1
(en)
|
2015-11-23 |
2022-10-26 |
The Regents of the University of California |
Tracking and manipulating cellular rna via nuclear delivery of crispr/cas9
|
|
CN105602987A
(zh)
|
2015-11-23 |
2016-05-25 |
深圳市默赛尔生物医学科技发展有限公司 |
一种高效的dc细胞xbp1基因敲除方法
|
|
US20170145438A1
(en)
|
2015-11-24 |
2017-05-25 |
University Of South Carolina |
Viral Vectors for Gene Editing
|
|
EP3382018B1
(en)
|
2015-11-25 |
2022-03-30 |
National University Corporation Gunma University |
Dna methylation editing kit and dna methylation editing method
|
|
US10240145B2
(en)
|
2015-11-25 |
2019-03-26 |
The Board Of Trustees Of The Leland Stanford Junior University |
CRISPR/Cas-mediated genome editing to treat EGFR-mutant lung cancer
|
|
US20180346940A1
(en)
|
2015-11-27 |
2018-12-06 |
The Regents Of The University Of California |
Compositions and methods for the production of hydrocarbons, hydrogen and carbon monoxide using engineered azotobacter strains
|
|
CN105505979A
(zh)
|
2015-11-28 |
2016-04-20 |
湖北大学 |
一种以CRISPR/Cas9基因编辑技术打靶Badh2基因获得香稻品系的方法
|
|
CN106811479B
(zh)
|
2015-11-30 |
2019-10-25 |
中国农业科学院作物科学研究所 |
利用CRISPR/Cas9系统定点修饰ALS基因获得抗除草剂水稻的系统及其应用
|
|
WO2017095111A1
(ko)
|
2015-11-30 |
2017-06-08 |
기초과학연구원 |
F. novicida 유래 Cas9을 포함하는 유전체 교정용 조성물
|
|
RU2634395C1
(ru)
|
2015-12-01 |
2017-10-26 |
Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Балтийский Федеральный Университет имени Иммануила Канта" (БФУ им. И. Канта) |
Генетическая конструкция на основе системы редактирования генома crispr/cas9, кодирующая нуклеазу cas9, специфически импортируемую в митохондрии клеток человека
|
|
CN105296518A
(zh)
|
2015-12-01 |
2016-02-03 |
中国农业大学 |
一种用于CRISPR/Cas9技术的同源臂载体构建方法
|
|
US11085057B2
(en)
|
2015-12-02 |
2021-08-10 |
The Regents Of The University Of California |
Compositions and methods for modifying a target nucleic acid
|
|
CA3007288A1
(en)
|
2015-12-02 |
2017-06-08 |
Ceres, Inc. |
Methods for genetic modification of plants
|
|
WO2017093370A1
(en)
|
2015-12-03 |
2017-06-08 |
Technische Universität München |
T-cell specific genome editing
|
|
CN105779449B
(zh)
|
2015-12-04 |
2018-11-27 |
新疆农业大学 |
一种棉花启动子GbU6-5PS及应用
|
|
CN105779448B
(zh)
|
2015-12-04 |
2018-11-27 |
新疆农业大学 |
一种棉花启动子GbU6-7PS及应用
|
|
US12037583B2
(en)
|
2015-12-04 |
2024-07-16 |
Novartis Ag |
Compositions and methods for immunooncology
|
|
CN105462968B
(zh)
|
2015-12-07 |
2018-10-16 |
北京信生元生物医学科技有限公司 |
一种靶向apoCⅢ的CRISPR-Cas9系统及其应用
|
|
CN106845151B
(zh)
|
2015-12-07 |
2019-03-26 |
中国农业大学 |
CRISPR-Cas9系统sgRNA作用靶点的筛选方法及装置
|
|
CA3006305A1
(en)
|
2015-12-09 |
2017-06-15 |
Excision Biotherapeutics, Inc. |
Gene editing methods and compositions for eliminating risk of jc virus activation and pml (progressive multifocal leukoencephalopathy) during immunosuppressive therapy
|
|
DK3387134T3
(da)
|
2015-12-11 |
2020-12-21 |
Danisco Us Inc |
Fremgangsmåder og sammensætninger til øget nukleasemedieret genommodifikation og reducerede virkninger uden for målstedet
|
|
CN105463003A
(zh)
|
2015-12-11 |
2016-04-06 |
扬州大学 |
一种消除卡那霉素耐药基因活性的重组载体及其构建方法
|
|
CN105296537A
(zh)
|
2015-12-12 |
2016-02-03 |
西南大学 |
一种基于睾丸内注射的基因定点编辑技术
|
|
WO2017105350A1
(en)
|
2015-12-14 |
2017-06-22 |
Cellresearch Corporation Pte Ltd |
A method of generating a mammalian stem cell carrying a transgene, a mammalian stem cell generated by the method and pharmaceuticals uses of the mammalian stem cell
|
|
CN105400773B
(zh)
|
2015-12-14 |
2018-06-26 |
同济大学 |
应用于大规模筛选癌症基因的CRISPR/Cas9富集测序方法
|
|
CN105463027A
(zh)
|
2015-12-17 |
2016-04-06 |
中国农业大学 |
一种高肌肉量及肥厚型心肌病模型克隆猪的制备方法
|
|
NO343153B1
(en)
|
2015-12-17 |
2018-11-19 |
Hydra Systems As |
A method of assessing the integrity status of a barrier plug
|
|
WO2017106616A1
(en)
|
2015-12-17 |
2017-06-22 |
The Regents Of The University Of Colorado, A Body Corporate |
Varicella zoster virus encoding regulatable cas9 nuclease
|
|
CA3008413A1
(en)
|
2015-12-18 |
2017-06-22 |
Sangamo Therapeutics, Inc. |
Targeted disruption of the t cell receptor
|
|
WO2017106657A1
(en)
|
2015-12-18 |
2017-06-22 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
WO2017105991A1
(en)
|
2015-12-18 |
2017-06-22 |
Danisco Us Inc. |
Methods and compositions for t-rna based guide rna expression
|
|
WO2017106767A1
(en)
|
2015-12-18 |
2017-06-22 |
The Scripps Research Institute |
Production of unnatural nucleotides using a crispr/cas9 system
|
|
MX2018007519A
(es)
|
2015-12-18 |
2019-09-04 |
Sangamo Therapeutics Inc |
Alteracion dirigida del receptor celular del complejo mayor de histocompatibilidad (mhc).
|
|
EP3392337B1
(en)
|
2015-12-18 |
2024-03-06 |
Japan Science and Technology Agency |
Genetic modification non-human organism, egg cells, fertilized eggs, and method for modifying target genes
|
|
US11118194B2
(en)
|
2015-12-18 |
2021-09-14 |
The Regents Of The University Of California |
Modified site-directed modifying polypeptides and methods of use thereof
|
|
US20200263165A1
(en)
|
2015-12-18 |
2020-08-20 |
Danisco Us Inc. |
Methods and compositions for polymerase ii (pol-ii) based guide rna expression
|
|
EP3701963A1
(en)
|
2015-12-22 |
2020-09-02 |
CureVac AG |
Method for producing rna molecule compositions
|
|
US11542466B2
(en)
|
2015-12-22 |
2023-01-03 |
North Carolina State University |
Methods and compositions for delivery of CRISPR based antimicrobials
|
|
WO2017109757A1
(en)
|
2015-12-23 |
2017-06-29 |
Crispr Therapeutics Ag |
Materials and methods for treatment of amyotrophic lateral sclerosis and/or frontal temporal lobular degeneration
|
|
CN105543270A
(zh)
|
2015-12-24 |
2016-05-04 |
中国农业科学院作物科学研究所 |
双抗性CRISPR/Cas9载体及应用
|
|
CN105543266A
(zh)
|
2015-12-25 |
2016-05-04 |
安徽大学 |
一种维吉尼亚链霉菌IBL14中的CRISPR-Cas系统及应用其进行基因编辑的方法
|
|
CN105505976A
(zh)
|
2015-12-25 |
2016-04-20 |
安徽大学 |
一种维吉尼亚链霉菌ibl14产青霉素重组菌株的构建方法
|
|
MY192848A
(en)
|
2015-12-28 |
2022-09-12 |
Intellia Therapeutics Inc |
Compositions and methods for the treatment of hemoglobinopathies
|
|
CN118374474A
(zh)
|
2015-12-29 |
2024-07-23 |
孟山都技术公司 |
新型crispr相关转座酶及其用途
|
|
CN105441451B
(zh)
|
2015-12-31 |
2019-03-22 |
暨南大学 |
一种特异靶向人ABCB1基因的sgRNA导向序列及应用
|
|
CN105567735A
(zh)
|
2016-01-05 |
2016-05-11 |
华东师范大学 |
一种凝血因子基因突变的定点修复载体系统及方法
|
|
CN108473986A
(zh)
|
2016-01-08 |
2018-08-31 |
诺维信公司 |
芽孢杆菌宿主细胞的基因组编辑
|
|
CN105647922A
(zh)
|
2016-01-11 |
2016-06-08 |
中国人民解放军疾病预防控制所 |
基于一种新gRNA序列的CRISPR-Cas9系统在制备乙肝治疗药物中的应用
|
|
US11441146B2
(en)
|
2016-01-11 |
2022-09-13 |
Christiana Care Health Services, Inc. |
Compositions and methods for improving homogeneity of DNA generated using a CRISPR/Cas9 cleavage system
|
|
WO2017123609A1
(en)
|
2016-01-12 |
2017-07-20 |
The Regents Of The University Of California |
Compositions and methods for enhanced genome editing
|
|
KR20180134847A
(ko)
|
2016-01-14 |
2018-12-19 |
멤피스 미츠 인코포레이티드 |
생체외 배양 과정 동안 체세포의 복제 능력을 증가시키는 방법
|
|
CA3011458A1
(en)
|
2016-01-14 |
2017-07-20 |
The Brigham And Women's Hospital, Inc. |
Genome editing for treating glioblastoma
|
|
EP3402327A1
(en)
|
2016-01-15 |
2018-11-21 |
The Jackson Laboratory |
Genetically modified non-human mammals by multi-cycle electroporation of cas9 protein
|
|
WO2017126987A1
(ru)
|
2016-01-18 |
2017-07-27 |
Анатолий Викторович ЗАЗУЛЯ |
Эритроциты для направленного транспорта лекарственного средства
|
|
CN105567734A
(zh)
|
2016-01-18 |
2016-05-11 |
丹弥优生物技术(湖北)有限公司 |
一种基因组dna序列精准编辑方法
|
|
CN105567738A
(zh)
|
2016-01-18 |
2016-05-11 |
南开大学 |
使用基因组编辑技术CRISPR-Cas9诱导CCR5Δ32缺失的方法
|
|
JP6914274B2
(ja)
|
2016-01-22 |
2021-08-04 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
Crisprcpf1の結晶構造
|
|
CA3011874A1
(en)
|
2016-01-25 |
2017-08-03 |
Excision Biotherapeutics, Inc. |
Methods and compositions for rna-guided treatment of hiv infection
|
|
CN105567689B
(zh)
|
2016-01-25 |
2019-04-09 |
重庆威斯腾生物医药科技有限责任公司 |
CRISPR/Cas9靶向敲除人TCAB1基因及其特异性gRNA
|
|
US20190038770A1
(en)
|
2016-01-25 |
2019-02-07 |
Excision Biotherapeutics,Inc. |
Rna guided eradication of human jc virus and other polyomaviruses
|
|
CN105543228A
(zh)
|
2016-01-25 |
2016-05-04 |
宁夏农林科学院 |
一种快速将水稻转化为香稻的方法
|
|
EP3199632A1
(en)
|
2016-01-26 |
2017-08-02 |
ACIB GmbH |
Temperature-inducible crispr/cas system
|
|
CN105567688A
(zh)
|
2016-01-27 |
2016-05-11 |
武汉大学 |
一种可用于艾滋病基因治疗的CRISPR/SaCas9系统
|
|
US11142550B2
(en)
|
2016-01-29 |
2021-10-12 |
The Trustees Of Princeton University |
Split inteins with exceptional splicing activity
|
|
AU2017213405B2
(en)
|
2016-01-30 |
2021-02-04 |
Bonac Corporation |
Artificial single guide RNA and use thereof
|
|
CN107022562B
(zh)
|
2016-02-02 |
2020-07-17 |
中国种子集团有限公司 |
利用CRISPR/Cas9系统对玉米基因定点突变的方法
|
|
CN105647968B
(zh)
|
2016-02-02 |
2019-07-23 |
浙江大学 |
一种CRISPR/Cas9工作效率快速测试系统及其应用
|
|
CN105671083B
(zh)
|
2016-02-03 |
2017-09-29 |
安徽柯顿生物科技有限公司 |
PD‑1基因重组病毒质粒及构建、重组逆转录病毒Lenti‑PD‑1‑Puro及包装与应用
|
|
WO2017136794A1
(en)
|
2016-02-03 |
2017-08-10 |
Massachusetts Institute Of Technology |
Structure-guided chemical modification of guide rna and its applications
|
|
WO2017136520A1
(en)
|
2016-02-04 |
2017-08-10 |
President And Fellows Of Harvard College |
Mitochondrial genome editing and regulation
|
|
US20190038780A1
(en)
|
2016-02-05 |
2019-02-07 |
Regents Of The University Of Minnesota |
Vectors and system for modulating gene expression
|
|
WO2017139264A1
(en)
|
2016-02-09 |
2017-08-17 |
President And Fellows Of Harvard College |
Dna-guided gene editing and regulation
|
|
CA3048963A1
(en)
|
2016-02-11 |
2017-08-17 |
The Regents Of The University Of California |
Methods and compositions for modifying a mutant dystrophin gene in a cell's genome
|
|
RU2016104674A
(ru)
|
2016-02-11 |
2017-08-16 |
Анатолий Викторович Зазуля |
Устройство модификации эритроцита с механизмом направленного транспорта лекарственного средства для функций генной терапии crispr/cas9
|
|
CN105647962A
(zh)
|
2016-02-15 |
2016-06-08 |
浙江大学 |
运用CRISPR-Cas9系统敲除水稻MIRNA393b茎环序列的基因编辑方法
|
|
US9896696B2
(en)
|
2016-02-15 |
2018-02-20 |
Benson Hill Biosystems, Inc. |
Compositions and methods for modifying genomes
|
|
AU2017219605B2
(en)
|
2016-02-15 |
2023-04-13 |
Temple University - Of The Commonwealth System Of Higher Education |
Excision of retroviral nucleic acid sequences
|
|
CN105647969B
(zh)
|
2016-02-16 |
2020-12-15 |
湖南师范大学 |
一种基因敲除选育stat1a基因缺失型斑马鱼的方法
|
|
AU2017221405A1
(en)
|
2016-02-16 |
2018-09-20 |
Carnegie Mellon University |
Compositions for enhancing targeted gene editing and methods of use thereof
|
|
CN105594664B
(zh)
|
2016-02-16 |
2018-10-02 |
湖南师范大学 |
一种基因敲除选育stat1a基因缺失型斑马鱼的方法
|
|
CN105624187A
(zh)
|
2016-02-17 |
2016-06-01 |
天津大学 |
酿酒酵母基因组定点突变的方法
|
|
EP3417065A4
(en)
|
2016-02-18 |
2019-07-17 |
President and Fellows of Harvard College |
METHOD AND SYSTEMS FOR MOLECULAR RECORDING BY CRISPR-CAS SYSTEM
|
|
DK3420080T3
(da)
|
2016-02-22 |
2019-11-25 |
Caribou Biosciences Inc |
Fremgangsmåde til modulering af dna-repair-resultater
|
|
US20170275665A1
(en)
|
2016-02-24 |
2017-09-28 |
Board Of Regents, The University Of Texas System |
Direct crispr spacer acquisition from rna by a reverse-transcriptase-cas1 fusion protein
|
|
CN105646719B
(zh)
|
2016-02-24 |
2019-12-20 |
无锡市妇幼保健院 |
一种高效定点转基因的工具及其应用
|
|
US20170246260A1
(en)
|
2016-02-25 |
2017-08-31 |
Agenovir Corporation |
Modified antiviral nuclease
|
|
US20170247703A1
(en)
|
2016-02-25 |
2017-08-31 |
Agenovir Corporation |
Antiviral nuclease methods
|
|
CA3015353A1
(en)
|
2016-02-25 |
2017-08-31 |
Agenovir Corporation |
Viral and oncoviral nuclease treatment
|
|
WO2017147278A1
(en)
|
2016-02-25 |
2017-08-31 |
The Children's Medical Center Corporation |
Customized class switch of immunoglobulin genes in lymphoma and hybridoma by crispr/cas9 technology
|
|
CN114908093A
(zh)
|
2016-02-26 |
2022-08-16 |
朗泽科技新西兰有限公司 |
用于c1固定菌的crispr/cas系统
|
|
US10538750B2
(en)
|
2016-02-29 |
2020-01-21 |
Agilent Technologies, Inc. |
Methods and compositions for blocking off-target nucleic acids from cleavage by CRISPR proteins
|
|
US11447768B2
(en)
|
2016-03-01 |
2022-09-20 |
University Of Florida Research Foundation, Incorporated |
Molecular cell diary system
|
|
CN105671070B
(zh)
|
2016-03-03 |
2019-03-19 |
江南大学 |
一种用于枯草芽孢杆菌基因组编辑的CRISPRCas9系统及其构建方法
|
|
CA3016331A1
(en)
|
2016-03-04 |
2017-09-08 |
Editas Medicine, Inc. |
Crispr-cpf1-related methods, compositions and components for cancer immunotherapy
|
|
CN105821039B
(zh)
|
2016-03-09 |
2020-02-07 |
李旭 |
联合免疫基因抑制HBV复制的特异性sgRNA、表达载体及其应用
|
|
CN105821040B
(zh)
|
2016-03-09 |
2018-12-14 |
李旭 |
联合免疫基因抑制高危型HPV表达的sgRNA、基因敲除载体及其应用
|
|
CN107177591A
(zh)
|
2016-03-09 |
2017-09-19 |
北京大学 |
利用CRISPR技术编辑CCR5基因的sgRNA序列及其用途
|
|
CN105861547A
(zh)
|
2016-03-10 |
2016-08-17 |
黄捷 |
身份证号码永久嵌入基因组的方法
|
|
US20190100762A1
(en)
|
2016-03-11 |
2019-04-04 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 systems and methods of use
|
|
US20180112234A9
(en)
|
2016-03-14 |
2018-04-26 |
Intellia Therapeutics, Inc. |
Methods and compositions for gene editing
|
|
WO2017160890A1
(en)
|
2016-03-14 |
2017-09-21 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating beta hemoglobinopathies
|
|
WO2017157422A1
(en)
|
2016-03-15 |
2017-09-21 |
Carrier Corporation |
Refrigerated sales cabinet
|
|
CA3029735A1
(en)
|
2016-03-15 |
2017-09-21 |
University Of Massachusetts |
Anti-crispr compounds and methods of use
|
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
|
WO2017161068A1
(en)
|
2016-03-18 |
2017-09-21 |
President And Fellows Of Harvard College |
Mutant cas proteins
|
|
US11597924B2
(en)
|
2016-03-25 |
2023-03-07 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
|
EP3433364A1
(en)
|
2016-03-25 |
2019-01-30 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
|
|
EP3436592A2
(en)
|
2016-03-28 |
2019-02-06 |
The Charles Stark Draper Laboratory, Inc. |
Bacteriophage engineering methods
|
|
CN106047803A
(zh)
|
2016-03-28 |
2016-10-26 |
青岛市胶州中心医院 |
CRISPR/Cas9靶向敲除兔BMP2基因的细胞模型及其应用
|
|
WO2017173004A1
(en)
|
2016-03-30 |
2017-10-05 |
Mikuni Takayasu |
A method for in vivo precise genome editing
|
|
SI3436077T1
(sl)
|
2016-03-30 |
2025-07-31 |
Intellia Therapeutics, Inc. |
Formulacije lipidnih nanodelcev za komponente crispr/cas
|
|
US20190093128A1
(en)
|
2016-03-31 |
2019-03-28 |
The Regents Of The University Of California |
Methods for genome editing in zygotes
|
|
US20190112599A1
(en)
|
2016-03-31 |
2019-04-18 |
President And Fellows Of Harvard College |
Methods and Compositions for the Single Tube Preparation of Sequencing Libraries Using Cas9
|
|
US10301619B2
(en)
|
2016-04-01 |
2019-05-28 |
New England Biolabs, Inc. |
Compositions and methods relating to synthetic RNA polynucleotides created from synthetic DNA oligonucleotides
|
|
CN106167525B
(zh)
|
2016-04-01 |
2019-03-19 |
北京康明百奥新药研发有限公司 |
筛选超低岩藻糖细胞系的方法和应用
|
|
JP2019513415A
(ja)
|
2016-04-04 |
2019-05-30 |
イーティーエッチ チューリッヒ |
タンパク質産生及びライブラリー生成のための哺乳類細胞株
|
|
WO2017176529A1
(en)
|
2016-04-06 |
2017-10-12 |
Temple Univesity-Of The Commonwealth System Of Higher Education |
Compositions for eradicating flavivirus infections in subjects
|
|
CN105802980A
(zh)
|
2016-04-08 |
2016-07-27 |
北京大学 |
Gateway兼容性CRISPR/Cas9系统及其应用
|
|
CN106399306B
(zh)
|
2016-04-12 |
2019-11-05 |
西安交通大学第一附属医院 |
靶向人lncRNA-UCA1抑制膀胱癌的sgRNA、基因载体及其应用
|
|
WO2017180915A2
(en)
|
2016-04-13 |
2017-10-19 |
Duke University |
Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
|
|
US20190062734A1
(en)
|
2016-04-13 |
2019-02-28 |
Editas Medicine, Inc. |
Grna fusion molecules, gene editing systems, and methods of use thereof
|
|
EP4047092B1
(en)
|
2016-04-13 |
2025-07-30 |
Editas Medicine, Inc. |
Cas9 fusion molecules, gene editing systems, and methods of use thereof
|
|
EP3442596A1
(en)
|
2016-04-14 |
2019-02-20 |
Université de Lausanne |
Treatment and/or prevention of dna-triplet repeat diseases or disorders
|
|
EP3443085B1
(en)
|
2016-04-14 |
2022-09-14 |
BOCO Silicon Valley, Inc. |
Genome editing of human neural stem cells using nucleases
|
|
CN105821116A
(zh)
|
2016-04-15 |
2016-08-03 |
扬州大学 |
一种绵羊mstn基因定向敲除及其影响成肌分化的检测方法
|
|
WO2017181107A2
(en)
|
2016-04-16 |
2017-10-19 |
Ohio State Innovation Foundation |
Modified cpf1 mrna, modified guide rna, and uses thereof
|
|
WO2017182468A1
(en)
|
2016-04-18 |
2017-10-26 |
Ruprecht-Karls-Universität Heidelberg |
Means and methods for inactivating therapeutic dna in a cell
|
|
US20190134227A1
(en)
|
2016-04-18 |
2019-05-09 |
The Board Of Regents Of The University Of Texas System |
Generation of genetically engineered animals by crispr/cas9 genome editing in spermatogonial stem cells
|
|
CA3026110A1
(en)
|
2016-04-19 |
2017-11-02 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
CA3026112A1
(en)
|
2016-04-19 |
2017-10-26 |
The Broad Institute, Inc. |
Cpf1 complexes with reduced indel activity
|
|
CN106086062A
(zh)
|
2016-04-19 |
2016-11-09 |
上海市农业科学院 |
一种获得番茄基因组定点敲除突变体的方法
|
|
SG10202010311SA
(en)
|
2016-04-19 |
2020-11-27 |
Broad Inst Inc |
Novel Crispr Enzymes and Systems
|
|
CN105886616B
(zh)
|
2016-04-20 |
2020-08-07 |
广东省农业科学院农业生物基因研究中心 |
一种用于猪基因编辑的高效特异性sgRNA识别位点引导序列及其筛选方法
|
|
CN105821075B
(zh)
|
2016-04-22 |
2017-09-12 |
湖南农业大学 |
一种茶树咖啡因合成酶CRISPR/Cas9基因组编辑载体的构建方法
|
|
CN107304435A
(zh)
|
2016-04-22 |
2017-10-31 |
中国科学院青岛生物能源与过程研究所 |
一种Cas9/RNA系统及其应用
|
|
WO2017189336A1
(en)
|
2016-04-25 |
2017-11-02 |
The Regents Of The University Of California |
Methods and compositions for genomic editing
|
|
CN105861552B
(zh)
|
2016-04-25 |
2019-10-11 |
西北农林科技大学 |
一种T7 RNA聚合酶介导的CRISPR/Cas9基因编辑系统的构建方法
|
|
CN107326046A
(zh)
|
2016-04-28 |
2017-11-07 |
上海邦耀生物科技有限公司 |
一种提高外源基因同源重组效率的方法
|
|
CN105886534A
(zh)
|
2016-04-29 |
2016-08-24 |
苏州溯源精微生物科技有限公司 |
一种抑制肿瘤转移的方法
|
|
KR102506185B1
(ko)
|
2016-04-29 |
2023-03-07 |
바스프 플랜트 사이언스 컴퍼니 게엠베하 |
표적 핵산의 변형을 위한 개선된 방법
|
|
CN105821049B
(zh)
|
2016-04-29 |
2019-06-04 |
中国农业大学 |
一种Fbxo40基因敲除猪的制备方法
|
|
KR102329187B1
(ko)
|
2016-04-29 |
2021-11-22 |
사렙타 쎄러퓨틱스, 인코퍼레이티드 |
인간 lmna를 표적화하는 올리고뉴클레오타이드 유사체
|
|
WO2017190257A1
(en)
|
2016-05-01 |
2017-11-09 |
Neemo Inc |
Harnessing heterologous and endogenous crispr-cas machineries for efficient markerless genome editing in clostridium
|
|
WO2017192573A1
(en)
|
2016-05-02 |
2017-11-09 |
Massachusetts Institute Of Technology |
Nanoparticle conjugates of highly potent toxins and intraperitoneal administration of nanoparticles for treating or imaging cancer
|
|
WO2017191210A1
(en)
|
2016-05-04 |
2017-11-09 |
Novozymes A/S |
Genome editing by crispr-cas9 in filamentous fungal host cells
|
|
WO2017191274A2
(en)
|
2016-05-04 |
2017-11-09 |
Curevac Ag |
Rna encoding a therapeutic protein
|
|
CN105950639A
(zh)
|
2016-05-04 |
2016-09-21 |
广州美格生物科技有限公司 |
金黄色葡萄球菌CRISPR/Cas9系统的制备及其在构建小鼠模型中的应用
|
|
CN105907785B
(zh)
|
2016-05-05 |
2020-02-07 |
苏州吉玛基因股份有限公司 |
化学合成的crRNA用于CRISPR/Cpf1系统在基因编辑中的应用
|
|
WO2017192172A1
(en)
|
2016-05-05 |
2017-11-09 |
Temple University - Of The Commonwealth System Of Higher Education |
Rna guided eradication of varicella zoster virus
|
|
WO2017190664A1
(zh)
|
2016-05-05 |
2017-11-09 |
苏州吉玛基因股份有限公司 |
化学合成的crRNA和修饰crRNA在CRISPR/Cpf1基因编辑系统中的应用
|
|
CN106244591A
(zh)
|
2016-08-23 |
2016-12-21 |
苏州吉玛基因股份有限公司 |
修饰crRNA在CRISPR/Cpf1基因编辑系统中的应用
|
|
WO2017193029A2
(en)
|
2016-05-05 |
2017-11-09 |
Duke University |
Crispr/cas-related methods and compositions for treating duchenne muscular dystrophy
|
|
CN105985985B
(zh)
|
2016-05-06 |
2019-12-31 |
苏州大学 |
Crispr技术编辑并用igf优化的异体间充质干细胞的制备方法及在治疗心梗中应用
|
|
CA3022319A1
(en)
|
2016-05-06 |
2017-11-09 |
Tod M. Woolf |
Improved methods for genome editing with and without programmable nucleases
|
|
US20190161743A1
(en)
|
2016-05-09 |
2019-05-30 |
President And Fellows Of Harvard College |
Self-Targeting Guide RNAs in CRISPR System
|
|
JP2019519250A
(ja)
|
2016-05-10 |
2019-07-11 |
ユナイテッド ステイツ ガバメント アズ リプレゼンテッド バイ ザ デパートメント オブ ベテランズ アフェアーズUnited States Government As Represented By The Department Of Veterans Affairs |
Hiv−1感染と複製に必須な遺伝子を切断するcrispr/casの構築物のレンチウィルスによる送達
|
|
CN105861554B
(zh)
|
2016-05-10 |
2020-01-31 |
华南农业大学 |
一种基于对Rbmy基因进行编辑来实现动物性别控制的方法和应用
|
|
US20190345483A1
(en)
|
2016-05-12 |
2019-11-14 |
President And Fellows Of Harvard College |
AAV Split Cas9 Genome Editing and Transcriptional Regulation
|
|
CN107365786A
(zh)
|
2016-05-12 |
2017-11-21 |
中国科学院微生物研究所 |
一种将spacer序列克隆至CRISPR-Cas9系统中的方法及其应用
|
|
US20200325483A1
(en)
|
2016-05-12 |
2020-10-15 |
Brian P. Hanley |
Safe delivery of crispr and other gene therapies to large fractions of somatic cells in humans and animals
|
|
CN105838733A
(zh)
|
2016-05-18 |
2016-08-10 |
云南省农业科学院花卉研究所 |
Cas9 介导的香石竹基因编辑载体和应用
|
|
CN105907758B
(zh)
|
2016-05-18 |
2020-06-05 |
世翱(上海)生物医药科技有限公司 |
CRISPR-Cas9引导序列及其引物、转基因表达载体及其构建方法
|
|
CN106011171B
(zh)
|
2016-05-18 |
2019-10-11 |
西北农林科技大学 |
一种利用CRISPR/Cas9技术基于SSA修复的基因无缝编辑方法
|
|
CN106446600B
(zh)
|
2016-05-20 |
2019-10-18 |
同济大学 |
一种基于CRISPR/Cas9的sgRNA的设计方法
|
|
KR102356542B1
(ko)
|
2016-05-20 |
2022-01-28 |
리제너론 파마슈티칼스 인코포레이티드 |
다중 가이드 RNAs를 이용한 면역학적 내성 파괴 방법
|
|
WO2017205423A1
(en)
|
2016-05-23 |
2017-11-30 |
Washington University |
Pulmonary targeted cas9/crispr for in vivo editing of disease genes
|
|
US20190300867A1
(en)
|
2016-05-23 |
2019-10-03 |
The Trustees Of Columbia University In The City Of New York |
Bypassing the pam requirement of the crispr-cas system
|
|
CN105950560B
(zh)
|
2016-05-24 |
2019-07-23 |
苏州系统医学研究所 |
人源化pd-l1肿瘤细胞系及具有该细胞系的动物模型与应用
|
|
CN106011167B
(zh)
|
2016-05-27 |
2019-11-01 |
上海交通大学 |
雄性不育基因OsDPW2的应用及水稻育性恢复的方法
|
|
BR112018074494A2
(pt)
|
2016-06-01 |
2019-03-19 |
Kws Saat Se & Co Kgaa |
sequências de ácidos nucleicos híbridas para engenharia genômica
|
|
WO2017208247A1
(en)
|
2016-06-02 |
2017-12-07 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. |
Assay for the removal of methyl-cytosine residues from dna
|
|
PT3604527T
(pt)
|
2016-06-02 |
2021-06-02 |
Sigma Aldrich Co Llc |
Utilização de proteínas de ligação ao dna programáveis para intensificar a modificação de genoma direcionada
|
|
US11140883B2
(en)
|
2016-06-03 |
2021-10-12 |
Auburn University |
Gene editing of reproductive hormones to sterilize aquatic animals
|
|
JP2019517503A
(ja)
|
2016-06-03 |
2019-06-24 |
テンプル ユニバーシティー オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション |
遺伝子編集戦略によるhiv−1のネガティブフィードバック調節
|
|
US20190256844A1
(en)
|
2016-06-07 |
2019-08-22 |
Temple University - Of The Commonwealth System Of Higher Education |
Rna guided compositions for preventing and treating hepatitis b virus infections
|
|
CN106119275A
(zh)
|
2016-06-07 |
2016-11-16 |
湖北大学 |
基于CRISPR/Cas9技术将非糯性水稻株系改造成糯性株系的打靶载体和方法
|
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
|
CN106086008B
(zh)
|
2016-06-10 |
2019-03-12 |
中国农业科学院植物保护研究所 |
烟粉虱MED隐种TRP基因的CRISPR/cas9系统及其应用
|
|
WO2017222834A1
(en)
|
2016-06-10 |
2017-12-28 |
City Of Hope |
Compositions and methods for mitochondrial genome editing
|
|
BR112018076027A2
(pt)
|
2016-06-14 |
2019-03-26 |
Pioneer Hi-Bred International, Inc. |
método para modificar uma sequência-alvo no genoma de uma célula vegetal; método para editar uma sequência de nucleotídeos no genoma de uma célula vegetal; método para modificar simultaneamente múltiplas sequências-alvo no genoma de uma célula vegetal; método para modificar uma sequênciaalvo de dna no genoma de uma célula vegetal e modelo de modificação de polinucleotídeo
|
|
CN106434752A
(zh)
|
2016-06-14 |
2017-02-22 |
南通大学附属医院 |
敲除Wnt3a基因的过程及其验证方法
|
|
CN105950633B
(zh)
|
2016-06-16 |
2019-05-03 |
复旦大学 |
基因OsARF4在控制水稻粒长和千粒重中的应用
|
|
CN106167821A
(zh)
|
2016-06-16 |
2016-11-30 |
郑州大学 |
一种金黄色葡萄球菌crispr位点检测试剂盒及检测方法
|
|
CN106167808A
(zh)
|
2016-06-16 |
2016-11-30 |
郑州大学 |
一种基于CRISPR/Cas9技术消除mecA质粒的方法
|
|
WO2017216771A2
(en)
|
2016-06-17 |
2017-12-21 |
Genesis Technologies Limited |
Crispr-cas system, materials and methods
|
|
CN105950626B
(zh)
|
2016-06-17 |
2018-09-28 |
新疆畜牧科学院生物技术研究所 |
基于CRISPR/Cas9获得不同毛色绵羊的方法及靶向ASIP基因的sgRNA
|
|
WO2017219033A1
(en)
|
2016-06-17 |
2017-12-21 |
Montana State University |
Bidirectional targeting for genome editing
|
|
WO2017219027A1
(en)
|
2016-06-17 |
2017-12-21 |
The Broad Institute Inc. |
Type vi crispr orthologs and systems
|
|
US20170362635A1
(en)
|
2016-06-20 |
2017-12-21 |
University Of Washington |
Muscle-specific crispr/cas9 editing of genes
|
|
WO2017223107A1
(en)
|
2016-06-20 |
2017-12-28 |
Unity Biotechnology, Inc. |
Genome modifying enzyme therapy for diseases modulated by senescent cells
|
|
ES2981548T3
(es)
|
2016-06-20 |
2024-10-09 |
Keygene Nv |
Método para la alteración dirigida del ADN en células vegetales
|
|
CA3018430A1
(en)
|
2016-06-20 |
2017-12-28 |
Pioneer Hi-Bred International, Inc. |
Novel cas systems and methods of use
|
|
CN106148370A
(zh)
|
2016-06-21 |
2016-11-23 |
苏州瑞奇生物医药科技有限公司 |
肥胖症大鼠动物模型和构建方法
|
|
WO2017223330A1
(en)
|
2016-06-22 |
2017-12-28 |
Icahn School Of Medicine At Mount Sinai |
Viral delivery of rna utilizing self-cleaving ribozymes and crispr-based applications thereof
|
|
KR102418185B1
(ko)
|
2016-06-22 |
2022-07-06 |
프로큐알 테라퓨틱스 Ⅱ 비.브이. |
단일 가닥 rna-편집 올리고뉴클레오타이드
|
|
CN106047877B
(zh)
|
2016-06-24 |
2019-01-11 |
中山大学附属第一医院 |
一种靶向敲除FTO基因的sgRNA及CRISPR/Cas9慢病毒系统与应用
|
|
CN106119283A
(zh)
|
2016-06-24 |
2016-11-16 |
广西壮族自治区水牛研究所 |
一种利用CRISPR‑Cas9靶向敲除MSTN基因的方法
|
|
CN105925608A
(zh)
|
2016-06-24 |
2016-09-07 |
广西壮族自治区水牛研究所 |
一种利用CRISPR-Cas9靶向敲除ALK6基因的方法
|
|
US20190185849A1
(en)
|
2016-06-29 |
2019-06-20 |
Crispr Therapeutics Ag |
Compositions and methods for gene editing
|
|
CN106148286B
(zh)
|
2016-06-29 |
2019-10-29 |
牛刚 |
一种用于检测热原的细胞模型的构建方法和细胞模型及热原检测试剂盒
|
|
WO2018005691A1
(en)
|
2016-06-29 |
2018-01-04 |
The Regents Of The University Of California |
Efficient genetic screening method
|
|
WO2018005873A1
(en)
|
2016-06-29 |
2018-01-04 |
The Broad Institute Inc. |
Crispr-cas systems having destabilization domain
|
|
US10927383B2
(en)
|
2016-06-30 |
2021-02-23 |
Ethris Gmbh |
Cas9 mRNAs
|
|
US20180004537A1
(en)
|
2016-07-01 |
2018-01-04 |
Microsoft Technology Licensing, Llc |
Molecular State Machines
|
|
US10892034B2
(en)
|
2016-07-01 |
2021-01-12 |
Microsoft Technology Licensing, Llc |
Use of homology direct repair to record timing of a molecular event
|
|
WO2018005117A1
(en)
|
2016-07-01 |
2018-01-04 |
Microsoft Technology Licensing, Llc |
Storage through iterative dna editing
|
|
SG10202109385QA
(en)
|
2016-07-05 |
2021-10-28 |
Univ Johns Hopkins |
Crispr/cas9-based compositions and methods for treating retinal degenerations
|
|
CN106191057B
(zh)
|
2016-07-06 |
2018-12-25 |
中山大学 |
一种用于敲除人CYP2E1基因的sgRNA序列、CYP2E1基因缺失细胞株的构建方法及其应用
|
|
EP3481959A1
(en)
|
2016-07-06 |
2019-05-15 |
Novozymes A/S |
Improving a microorganism by crispr-inhibition
|
|
CN106051058A
(zh)
|
2016-07-07 |
2016-10-26 |
上海格昆机电科技有限公司 |
用于航天贮箱和粒子治疗仪的旋转机架及其传动机构
|
|
US11845929B2
(en)
|
2016-07-08 |
2023-12-19 |
Ohio State Innovation Foundation |
Modified nucleic acids, hybrid guide RNAs, and uses thereof
|
|
CN107586777A
(zh)
|
2016-07-08 |
2018-01-16 |
上海吉倍生物技术有限公司 |
人PDCD1基因sgRNA的用途及其相关药物
|
|
CN106047930B
(zh)
|
2016-07-12 |
2020-05-19 |
北京百奥赛图基因生物技术有限公司 |
一种PS1基因条件性敲除flox大鼠的制备方法
|
|
EP3484994A4
(en)
|
2016-07-13 |
2020-01-22 |
DSM IP Assets B.V. |
A crispr-cas system for an algal host cell
|
|
WO2018013990A1
(en)
|
2016-07-15 |
2018-01-18 |
Zymergen Inc. |
Scarless dna assembly and genome editing using crispr/cpf1 and dna ligase
|
|
US11674158B2
(en)
|
2016-07-15 |
2023-06-13 |
Salk Institute For Biological Studies |
Methods and compositions for genome editing in non-dividing cells
|
|
CN106191062B
(zh)
|
2016-07-18 |
2019-06-14 |
广东华南疫苗股份有限公司 |
一种tcr-/pd-1-双阴性t细胞及其构建方法
|
|
CN106191061B
(zh)
|
2016-07-18 |
2019-06-18 |
暨南大学 |
一种特异靶向人ABCG2基因的sgRNA导向序列及其应用
|
|
CN106190903B
(zh)
|
2016-07-18 |
2019-04-02 |
华中农业大学 |
鸭疫里氏杆菌Cas9基因缺失突变株及其应用
|
|
WO2018017754A1
(en)
|
2016-07-19 |
2018-01-25 |
Duke University |
Therapeutic applications of cpf1-based genome editing
|
|
CN106434651B
(zh)
|
2016-07-19 |
2021-05-18 |
广西大学 |
根癌农杆菌和CRISPR-Cas9介导的基因定点插入失活方法及其应用
|
|
KR20190031306A
(ko)
|
2016-07-21 |
2019-03-25 |
맥스시티 인코포레이티드 |
게놈 dna를 변경하기 위한 방법 및 조성물
|
|
CN106191064B
(zh)
|
2016-07-22 |
2019-06-07 |
中国农业大学 |
一种制备mc4r基因敲除猪的方法
|
|
WO2018015444A1
(en)
|
2016-07-22 |
2018-01-25 |
Novozymes A/S |
Crispr-cas9 genome editing with multiple guide rnas in filamentous fungi
|
|
CN106191107B
(zh)
|
2016-07-22 |
2020-03-20 |
湖南农业大学 |
一种降低水稻籽粒落粒性的分子改良方法
|
|
EP3488001A4
(en)
|
2016-07-25 |
2019-05-29 |
Mayo Foundation for Medical Education and Research |
TREATMENT OF CANCER
|
|
WO2018018979A1
(zh)
|
2016-07-26 |
2018-02-01 |
浙江大学 |
植物重组载体及无转基因成分的基因编辑植株的筛选方法
|
|
WO2018022634A1
(en)
|
2016-07-26 |
2018-02-01 |
The General Hospital Corporation |
Variants of crispr from prevotella and francisella 1 (cpf1)
|
|
CN106222193B
(zh)
|
2016-07-26 |
2019-09-20 |
浙江大学 |
一种重组载体及无转基因基因编辑植株的筛选方法
|
|
CN106191099A
(zh)
|
2016-07-27 |
2016-12-07 |
苏州泓迅生物科技有限公司 |
一种基于CRISPR‑Cas9系统的酿酒酵母基因组并行多重编辑载体及其应用
|
|
CN106086061A
(zh)
|
2016-07-27 |
2016-11-09 |
苏州泓迅生物科技有限公司 |
一种基于CRISPR‑Cas9系统的酿酒酵母基因组编辑载体及其应用
|
|
KR101828958B1
(ko)
|
2016-07-28 |
2018-02-13 |
주식회사 비엠티 |
옥외 배관용 히팅재킷
|
|
CN106434748A
(zh)
|
2016-07-29 |
2017-02-22 |
中国科学院重庆绿色智能技术研究院 |
一种热激诱导型 Cas9 酶转基因斑马鱼的研制及应用
|
|
GB201613135D0
(en)
|
2016-07-29 |
2016-09-14 |
Medical Res Council |
Genome editing
|
|
CN106191124B
(zh)
|
2016-07-29 |
2019-10-11 |
中国科学院重庆绿色智能技术研究院 |
一种利用鱼卵保存液提高CRISPR-Cas9基因编辑和传代效率的鱼类育种方法
|
|
CN106191113B
(zh)
|
2016-07-29 |
2020-01-14 |
中国农业大学 |
一种mc3r基因敲除猪的制备方法
|
|
CN106191114B
(zh)
|
2016-07-29 |
2020-02-11 |
中国科学院重庆绿色智能技术研究院 |
利用CRISPR-Cas9系统敲除鱼类MC4R基因的育种方法
|
|
CA3030340A1
(en)
|
2016-08-01 |
2018-02-08 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Human induced pluripotent stem cells for high efficiency genetic engineering
|
|
CN106011150A
(zh)
|
2016-08-01 |
2016-10-12 |
云南纳博生物科技有限公司 |
一种水稻穗粒数Gn1a基因人工定点突变体及其应用
|
|
CN106434688A
(zh)
|
2016-08-01 |
2017-02-22 |
云南纳博生物科技有限公司 |
一种水稻直立密穗dep1基因人工定点突变体及其应用
|
|
JP7184364B2
(ja)
|
2016-08-02 |
2022-12-06 |
国立大学法人京都大学 |
ゲノム編集のための方法
|
|
WO2018026976A1
(en)
|
2016-08-02 |
2018-02-08 |
Editas Medicine, Inc. |
Compositions and methods for treating cep290 associated disease
|
|
KR102547316B1
(ko)
|
2016-08-03 |
2023-06-23 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
아데노신 핵염기 편집제 및 그의 용도
|
|
CN106282241A
(zh)
|
2016-08-05 |
2017-01-04 |
无锡市第二人民医院 |
通过CRISPR/Cas9得到敲除bmp2a基因的斑马鱼的方法
|
|
WO2018031683A1
(en)
|
2016-08-09 |
2018-02-15 |
President And Fellows Of Harvard College |
Programmable cas9-recombinase fusion proteins and uses thereof
|
|
KR101710026B1
(ko)
|
2016-08-10 |
2017-02-27 |
주식회사 무진메디 |
Cas9 단백질 및 가이드 RNA의 혼성체를 함유하는 나노 리포좀 전달체 조성물
|
|
CN106222203A
(zh)
|
2016-08-10 |
2016-12-14 |
云南纳博生物科技有限公司 |
利用CRISPR/Cas技术获得家蚕丝素重链基因突变体及突变方法和应用
|
|
CN106172238B
(zh)
|
2016-08-12 |
2019-01-22 |
中南大学 |
miR-124基因敲除小鼠动物模型的构建方法和应用
|
|
CN106222177B
(zh)
|
2016-08-13 |
2018-06-26 |
江苏集萃药康生物科技有限公司 |
一种靶向人STAT6的CRISPR-Cas9系统及其用于治疗过敏性疾病的应用
|
|
US11810649B2
(en)
|
2016-08-17 |
2023-11-07 |
The Broad Institute, Inc. |
Methods for identifying novel gene editing elements
|
|
WO2018035250A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute, Inc. |
Methods for identifying class 2 crispr-cas systems
|
|
WO2018035300A1
(en)
|
2016-08-17 |
2018-02-22 |
The Regents Of The University Of California |
Split trans-complementing gene-drive system for suppressing aedes aegypti mosquitos
|
|
US20200340012A1
(en)
|
2016-08-18 |
2020-10-29 |
The Regents Of The University Of California |
Crispr-cas genome engineering via a modular aav delivery system
|
|
CN109715171A
(zh)
|
2016-08-19 |
2019-05-03 |
蓝鸟生物公司 |
基因组编辑增强子
|
|
US20190185850A1
(en)
|
2016-08-20 |
2019-06-20 |
Avellino Lab Usa, Inc. |
Single guide rna/crispr/cas9 systems, and methods of use thereof
|
|
CN106191071B
(zh)
|
2016-08-22 |
2018-09-04 |
广州资生生物科技有限公司 |
一种CRISPR-Cas9系统及其用于治疗乳腺癌疾病的应用
|
|
CN106191116B
(zh)
|
2016-08-22 |
2019-10-08 |
西北农林科技大学 |
基于CRISPR/Cas9的外源基因敲入整合系统及其建立方法和应用
|
|
CN106086028B
(zh)
|
2016-08-23 |
2019-04-23 |
中国农业科学院作物科学研究所 |
一种通过基因组编辑提高水稻抗性淀粉含量的方法及其专用sgRNA
|
|
CN106244555A
(zh)
|
2016-08-23 |
2016-12-21 |
广州医科大学附属第三医院 |
一种提高基因打靶的效率的方法及β‑球蛋白基因位点的碱基原位修复方法
|
|
CN106109417A
(zh)
|
2016-08-24 |
2016-11-16 |
李因传 |
一种肝细胞膜仿生脂质体药物载体、制作方法及其应用
|
|
CN106244609A
(zh)
|
2016-08-24 |
2016-12-21 |
浙江理工大学 |
一种调节pi3k‑akt信号通路的非编码基因的筛选系统及筛选方法
|
|
PT3504229T
(pt)
|
2016-08-24 |
2021-12-13 |
Sangamo Therapeutics Inc |
Regulação da expressão de genes utilizando nucleases modificadas
|
|
JP7272948B2
(ja)
|
2016-08-24 |
2023-05-12 |
サンガモ セラピューティクス, インコーポレイテッド |
操作された標的特異的ヌクレアーゼ
|
|
KR101856345B1
(ko)
|
2016-08-24 |
2018-06-20 |
경상대학교산학협력단 |
CRISPR/Cas9 시스템을 이용하여 APOBEC3H 및 APOBEC3CH 이중-넉아웃 고양이를 제조하는 방법
|
|
WO2018039438A1
(en)
*
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
CN106544357B
(zh)
|
2016-08-25 |
2018-08-21 |
湖南杂交水稻研究中心 |
一种培育镉低积累籼稻品种的方法
|
|
CN107784200B
(zh)
|
2016-08-26 |
2020-11-06 |
深圳华大生命科学研究院 |
一种筛选新型CRISPR-Cas系统的方法和装置
|
|
CN106350540A
(zh)
|
2016-08-26 |
2017-01-25 |
苏州系统医学研究所 |
一种由慢病毒介导的高效可诱导型CRISPR/Cas9基因敲除载体及其应用
|
|
CN106318973B
(zh)
|
2016-08-26 |
2019-09-13 |
深圳市第二人民医院 |
一种基于CRISPR-Cas9的基因调控装置及基因调控方法
|
|
CN106399367A
(zh)
|
2016-08-31 |
2017-02-15 |
深圳市卫光生物制品股份有限公司 |
提高crispr介导的同源重组效率的方法
|
|
CN106480097A
(zh)
|
2016-10-13 |
2017-03-08 |
南京凯地生物科技有限公司 |
利用CRISPR/Cas9技术敲除人PD‑1基因构建可靶向MSLN新型CAR‑T细胞的方法及其应用
|
|
CN106399375A
(zh)
|
2016-08-31 |
2017-02-15 |
南京凯地生物科技有限公司 |
利用CRISPR/Cas9敲除人PD‑1基因构建靶向CD19CAR‑T细胞的方法
|
|
CN107794272B
(zh)
|
2016-09-06 |
2021-10-12 |
中国科学院上海营养与健康研究所 |
一种高特异性的crispr基因组编辑体系
|
|
CA3035910A1
(en)
|
2016-09-07 |
2018-03-15 |
Flagship Pioneering, Inc. |
Methods and compositions for modulating gene expression
|
|
WO2018048827A1
(en)
|
2016-09-07 |
2018-03-15 |
Massachusetts Institute Of Technology |
Rna-guided endonuclease-based dna assembly
|
|
CN106367435B
(zh)
|
2016-09-07 |
2019-11-08 |
电子科技大学 |
一种水稻miRNA定向敲除的方法
|
|
CN106399377A
(zh)
|
2016-09-07 |
2017-02-15 |
同济大学 |
一种基于CRISPR/Cas9高通量技术筛选药物靶点基因的方法
|
|
CN106399311A
(zh)
|
2016-09-07 |
2017-02-15 |
同济大学 |
用于Chip‑seq全基因组结合谱的内源蛋白标记的方法
|
|
EP3510151B1
(en)
|
2016-09-09 |
2024-07-03 |
The Board of Trustees of the Leland Stanford Junior University |
High-throughput precision genome editing
|
|
CN107574179B
(zh)
|
2016-09-09 |
2018-07-10 |
康码(上海)生物科技有限公司 |
一种为克鲁维酵母优化的CRISPR/Cas9高效基因编辑系统
|
|
WO2018051347A1
(en)
|
2016-09-14 |
2018-03-22 |
Yeda Research And Development Co. Ltd. |
Crisp-seq, an integrated method for massively parallel single cell rna-seq and crispr pooled screens
|
|
CN106318934B
(zh)
|
2016-09-21 |
2020-06-05 |
上海交通大学 |
胡萝卜β(1,2)木糖转移酶的基因全序列及用于转染双子叶植物的CRISPR/CAS9的质粒构建
|
|
DK3516056T3
(da)
|
2016-09-23 |
2025-02-17 |
Dsm Ip Assets Bv |
Et guide-rna-ekspressionssystem til en værtscelle
|
|
EP3516058A1
(en)
|
2016-09-23 |
2019-07-31 |
Casebia Therapeutics Limited Liability Partnership |
Compositions and methods for gene editing
|
|
CN106957858A
(zh)
|
2016-09-23 |
2017-07-18 |
西北农林科技大学 |
一种利用CRISPR/Cas9系统共同敲除绵羊MSTN、ASIP、BCO2基因的方法
|
|
US9580698B1
(en)
|
2016-09-23 |
2017-02-28 |
New England Biolabs, Inc. |
Mutant reverse transcriptase
|
|
WO2018062866A2
(en)
|
2016-09-28 |
2018-04-05 |
Cellivery Therapeutics, Inc. |
CELL-PERMEABLE (CP)-Cas9 RECOMBINANT PROTEIN AND USES THEREOF
|
|
US11873504B2
(en)
|
2016-09-30 |
2024-01-16 |
The Regents Of The University Of California |
RNA-guided nucleic acid modifying enzymes and methods of use thereof
|
|
CN107880132B
(zh)
|
2016-09-30 |
2022-06-17 |
北京大学 |
一种融合蛋白及使用其进行同源重组的方法
|
|
EP3518656A4
(en)
|
2016-09-30 |
2020-09-30 |
Monsanto Technology LLC |
PROCESS FOR SELECTING TARGET SITES FOR MODIFICATION OF SITE-SPECIFIC GENOME IN PLANTS
|
|
CN106480027A
(zh)
|
2016-09-30 |
2017-03-08 |
重庆高圣生物医药有限责任公司 |
CRISPR/Cas9 靶向敲除人PD‑1基因及其特异性gRNA
|
|
CA3038982A1
(en)
|
2016-09-30 |
2018-04-05 |
The Regents Of The University Of California |
Rna-guided nucleic acid modifying enzymes and methods of use thereof
|
|
CN107881184B
(zh)
|
2016-09-30 |
2021-08-27 |
中国科学院分子植物科学卓越创新中心 |
一种基于Cpf1的DNA体外拼接方法
|
|
US11730823B2
(en)
|
2016-10-03 |
2023-08-22 |
President And Fellows Of Harvard College |
Delivery of therapeutic RNAs via ARRDC1-mediated microvesicles
|
|
WO2018067846A1
(en)
|
2016-10-05 |
2018-04-12 |
President And Fellows Of Harvard College |
Methods of crispr mediated genome modulation in v. natriegens
|
|
US10669539B2
(en)
|
2016-10-06 |
2020-06-02 |
Pioneer Biolabs, Llc |
Methods and compositions for generating CRISPR guide RNA libraries
|
|
KR102606680B1
(ko)
|
2016-10-07 |
2023-11-27 |
인티그레이티드 디엔에이 테크놀로지스 아이엔씨. |
S. 피오게네스 cas9 돌연변이 유전자 및 이에 의해 암호화되는 폴리펩티드
|
|
CN106479985A
(zh)
|
2016-10-09 |
2017-03-08 |
上海吉玛制药技术有限公司 |
病毒介导的Cpf1蛋白在CRISPR/Cpf1基因编辑系统中的应用
|
|
IT201600102542A1
(it)
|
2016-10-12 |
2018-04-12 |
Univ Degli Studi Di Trento |
Plasmide e sistema lentivirale contenente un circuito autolimitante della Cas9 che ne incrementa la sicurezza.
|
|
CN106434663A
(zh)
|
2016-10-12 |
2017-02-22 |
遵义医学院 |
CRISPR/Cas9靶向敲除人ezrin基因增强子关键区的方法及其特异性gRNA
|
|
WO2018071623A2
(en)
|
2016-10-12 |
2018-04-19 |
Temple University - Of The Commonwealth System Of Higher Education |
Combination therapies for eradicating flavivirus infections in subjects
|
|
SG11201903089RA
(en)
|
2016-10-14 |
2019-05-30 |
Harvard College |
Aav delivery of nucleobase editors
|
|
CA3040481A1
(en)
|
2016-10-14 |
2018-04-19 |
The General Hospital Corporation |
Epigenetically regulated site-specific nucleases
|
|
CN106434782B
(zh)
|
2016-10-14 |
2020-01-10 |
南京工业大学 |
一种产顺式-4-羟脯氨酸的方法
|
|
US20190330620A1
(en)
|
2016-10-14 |
2019-10-31 |
Emendobio Inc. |
Rna compositions for genome editing
|
|
SG10201913505WA
(en)
|
2016-10-17 |
2020-02-27 |
Univ Nanyang Tech |
Truncated crispr-cas proteins for dna targeting
|
|
US10640810B2
(en)
|
2016-10-19 |
2020-05-05 |
Drexel University |
Methods of specifically labeling nucleic acids using CRISPR/Cas
|
|
WO2018081504A1
(en)
|
2016-10-28 |
2018-05-03 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating herpes simplex virus
|
|
US20180127759A1
(en)
|
2016-10-28 |
2018-05-10 |
Massachusetts Institute Of Technology |
Dynamic genome engineering
|
|
WO2018080573A1
(en)
|
2016-10-28 |
2018-05-03 |
Massachusetts Institute Of Technology |
Crispr/cas global regulator screening platform
|
|
WO2018081728A1
(en)
|
2016-10-31 |
2018-05-03 |
Emendobio Inc. |
Compositions for genome editing
|
|
WO2018079134A1
(ja)
|
2016-10-31 |
2018-05-03 |
株式会社江口高周波 |
リアクトル
|
|
EP3535396A1
(en)
|
2016-11-01 |
2019-09-11 |
Novartis AG |
Methods and compositions for enhancing gene editing
|
|
WO2018085288A1
(en)
|
2016-11-01 |
2018-05-11 |
President And Fellows Of Harvard College |
Inhibitors of rna guided nucleases and uses thereof
|
|
GB201618507D0
(en)
|
2016-11-02 |
2016-12-14 |
Stichting Voor De Technische Wetenschappen And Wageningen Univ |
Microbial genome editing
|
|
WO2018085414A1
(en)
|
2016-11-02 |
2018-05-11 |
President And Fellows Of Harvard College |
Engineered guide rna sequences for in situ detection and sequencing
|
|
CN106544353A
(zh)
|
2016-11-08 |
2017-03-29 |
宁夏医科大学总医院 |
一种利用CRISPR‑Cas9清除鲍曼不动杆菌耐药性基因的方法
|
|
CN106755088A
(zh)
|
2016-11-11 |
2017-05-31 |
广东万海细胞生物科技有限公司 |
一种自体car‑t细胞制备方法及应用
|
|
EP3538561A4
(en)
|
2016-11-11 |
2020-10-21 |
The Regents of The University of California |
RNA-GUIDED VARIANT POLYPEPTIDES AND THEIR METHODS OF USE
|
|
CN106566838B
(zh)
|
2016-11-14 |
2019-11-01 |
上海伯豪生物技术有限公司 |
一种基于CRISPR-Cas9技术的miR-126全长基因敲除试剂盒及其应用
|
|
EA201990815A1
(ru)
|
2016-11-14 |
2019-09-30 |
Институте Оф Генетисс Анд Девелопментал Биологй. Чинесе Асадемй Оф Ссиенсес |
Способ редактирования основания у растений
|
|
CN106554969A
(zh)
|
2016-11-15 |
2017-04-05 |
陕西理工学院 |
基于抑菌杀菌的多靶点CRISPR/Cas9表达载体
|
|
CN106754912B
(zh)
|
2016-11-16 |
2019-11-08 |
上海交通大学 |
一类定向清除肝细胞中HBVcccDNA的质粒及制剂
|
|
CN110139927B
(zh)
|
2016-11-16 |
2024-06-07 |
加利福尼亚大学董事会 |
Crispr-cas9抑制剂
|
|
CN106480067A
(zh)
|
2016-11-21 |
2017-03-08 |
中国农业科学院烟草研究所 |
烟草NtNAC096基因控制烟草衰老的应用
|
|
US20180282722A1
(en)
|
2016-11-21 |
2018-10-04 |
Massachusetts Institute Of Technology |
Chimeric DNA:RNA Guide for High Accuracy Cas9 Genome Editing
|
|
CN110402287A
(zh)
|
2016-11-22 |
2019-11-01 |
综合Dna技术公司 |
CRISPR/Cpf1系统和方法
|
|
CN110382695A
(zh)
|
2016-11-28 |
2019-10-25 |
得克萨斯州大学系统董事会 |
通过crispr/cpf1介导的基因编辑来预防肌营养不良
|
|
CN106755091A
(zh)
|
2016-11-28 |
2017-05-31 |
中国人民解放军第三军医大学第附属医院 |
基因敲除载体,mh7a细胞nlrp1基因敲除方法
|
|
CN106480036B
(zh)
|
2016-11-30 |
2019-04-09 |
华南理工大学 |
一种具有启动子功能的dna片段及其应用
|
|
CN106834323A
(zh)
|
2016-12-01 |
2017-06-13 |
安徽大学 |
一种基于维吉尼亚链霉菌IBL14基因cas7‑5‑3的基因编辑方法
|
|
CN107043779B
(zh)
|
2016-12-01 |
2020-05-12 |
中国农业科学院作物科学研究所 |
一种CRISPR/nCas9介导的定点碱基替换在植物中的应用
|
|
US20200056206A1
(en)
|
2016-12-01 |
2020-02-20 |
UNIVERSITé LAVAL |
Crispr-based treatment of friedreich ataxia
|
|
US9816093B1
(en)
|
2016-12-06 |
2017-11-14 |
Caribou Biosciences, Inc. |
Engineered nucleic acid-targeting nucleic acids
|
|
CN106701830B
(zh)
|
2016-12-07 |
2020-01-03 |
湖南人文科技学院 |
一种敲除猪胚胎p66shc基因的方法
|
|
CN108165573B
(zh)
|
2016-12-07 |
2022-01-14 |
中国科学院分子植物科学卓越创新中心 |
叶绿体基因组编辑方法
|
|
CN106544351B
(zh)
|
2016-12-08 |
2019-09-10 |
江苏省农业科学院 |
CRISPR-Cas9体外敲除耐药基因mcr-1的方法及其专用细胞穿透肽
|
|
MY206324A
(en)
|
2016-12-08 |
2024-12-10 |
Intellia Therapeutics Inc |
Modified guide rnas
|
|
US11192929B2
(en)
|
2016-12-08 |
2021-12-07 |
Regents Of The University Of Minnesota |
Site-specific DNA base editing using modified APOBEC enzymes
|
|
AU2017371324B2
(en)
|
2016-12-09 |
2024-06-13 |
Massachusetts Institute Of Technology |
CRISPR effector system based diagnostics
|
|
US12404514B2
(en)
|
2016-12-09 |
2025-09-02 |
The Broad Institute, Inc. |
CRISPR-systems for modifying a trait of interest in a plant
|
|
WO2018111947A1
(en)
|
2016-12-12 |
2018-06-21 |
Integrated Dna Technologies, Inc. |
Genome editing enhancement
|
|
WO2018111946A1
(en)
|
2016-12-12 |
2018-06-21 |
Integrated Dna Technologies, Inc. |
Genome editing detection
|
|
CN107893074A
(zh)
|
2016-12-13 |
2018-04-10 |
广东赤萌医疗科技有限公司 |
一种用于敲除CXCR4基因的gRNA、表达载体、敲除系统、试剂盒
|
|
WO2018108272A1
(en)
|
2016-12-14 |
2018-06-21 |
Wageningen Universiteit |
Thermostable cas9 nucleases
|
|
WO2018109101A1
(en)
|
2016-12-14 |
2018-06-21 |
Wageningen Universiteit |
Thermostable cas9 nucleases
|
|
WO2018112336A1
(en)
|
2016-12-16 |
2018-06-21 |
Ohio State Innovation Foundation |
Systems and methods for dna-guided rna cleavage
|
|
KR101748575B1
(ko)
|
2016-12-16 |
2017-06-20 |
주식회사 엠젠플러스 |
Ins 유전자 녹아웃 당뇨병 또는 당뇨병 합병증 동물모델 및 이의 제조방법
|
|
WO2018112446A2
(en)
|
2016-12-18 |
2018-06-21 |
Selonterra, Inc. |
Use of apoe4 motif-mediated genes for diagnosis and treatment of alzheimer's disease
|
|
CN106755026A
(zh)
|
2016-12-18 |
2017-05-31 |
吉林大学 |
sgRNA表达载体的构建及牙釉质钙化不全模型的建立
|
|
IL267500B2
(en)
|
2016-12-23 |
2025-07-01 |
Harvard College |
Gene editing of pcsk9 and related methods, compositions, and uses thereof
|
|
US10745677B2
(en)
|
2016-12-23 |
2020-08-18 |
President And Fellows Of Harvard College |
Editing of CCR5 receptor gene to protect against HIV infection
|
|
CN106755424B
(zh)
|
2016-12-26 |
2020-11-06 |
郑州大学 |
一种基于crispr的大肠杆菌st131系菌株检测引物、试剂盒及检测方法
|
|
CN107354173A
(zh)
|
2016-12-26 |
2017-11-17 |
浙江省医学科学院 |
基于crispr技术和水动力尾静脉注射建立肝脏特异性敲除小鼠模型的方法
|
|
CN106755097A
(zh)
|
2016-12-27 |
2017-05-31 |
安徽省农业科学院畜牧兽医研究所 |
一种山羊tlr4基因敲除载体及其构建方法
|
|
CN106834347A
(zh)
|
2016-12-27 |
2017-06-13 |
安徽省农业科学院畜牧兽医研究所 |
一种山羊cdk2基因敲除载体及其构建方法
|
|
CN106597260B
(zh)
|
2016-12-29 |
2020-04-03 |
合肥工业大学 |
基于连续小波分析和elm网络的模拟电路故障诊断方法
|
|
CN106755077A
(zh)
|
2016-12-30 |
2017-05-31 |
华智水稻生物技术有限公司 |
利用crispr‑cas9技术对水稻cenh3基因定点突变的方法
|
|
CN106701763B
(zh)
|
2016-12-30 |
2019-07-19 |
重庆高圣生物医药有限责任公司 |
CRISPR/Cas9靶向敲除人乙肝病毒P基因及其特异性gRNA
|
|
CN106868008A
(zh)
|
2016-12-30 |
2017-06-20 |
重庆高圣生物医药有限责任公司 |
CRISPR/Cas9靶向敲除人Lin28A基因及其特异性gRNA
|
|
CN106834341B
(zh)
|
2016-12-30 |
2020-06-16 |
中国农业大学 |
一种基因定点突变载体及其构建方法和应用
|
|
CN106701818B
(zh)
|
2017-01-09 |
2020-04-24 |
湖南杂交水稻研究中心 |
一种培育水稻普通核不育系的方法
|
|
EP3568476A1
(en)
|
2017-01-11 |
2019-11-20 |
Oxford University Innovation Limited |
Crispr rna
|
|
CN107012164B
(zh)
|
2017-01-11 |
2023-03-03 |
电子科技大学 |
CRISPR/Cpf1植物基因组定向修饰功能单元、包含该功能单元的载体及其应用
|
|
WO2018135838A2
(ko)
|
2017-01-17 |
2018-07-26 |
기초과학연구원 |
Dna 단일가닥 절단에 의한 염기 교정 비표적 위치 확인 방법
|
|
JP2020513783A
(ja)
|
2017-01-18 |
2020-05-21 |
エクシジョン バイオセラピューティクス インコーポレイテッド |
Crispr
|
|
CN107058372A
(zh)
|
2017-01-18 |
2017-08-18 |
四川农业大学 |
一种应用于植物上的CRISPR/Cas9载体的构建方法
|
|
CN106701823A
(zh)
|
2017-01-18 |
2017-05-24 |
上海交通大学 |
生产无岩藻糖单克隆抗体的cho细胞系建立及其应用
|
|
CN106801056A
(zh)
|
2017-01-24 |
2017-06-06 |
中国科学院广州生物医药与健康研究院 |
一种sgRNA及其构建的慢病毒载体和应用
|
|
EP3574101B1
(en)
|
2017-01-30 |
2023-04-19 |
KWS SAAT SE & Co. KGaA |
Repair template linkage to endonucleases for genome engineering
|
|
TWI608100B
(zh)
|
2017-02-03 |
2017-12-11 |
國立清華大學 |
Cas9表達質體、大腸桿菌基因剪輯系統及其方法
|
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
WO2018148246A1
(en)
|
2017-02-07 |
2018-08-16 |
Massachusetts Institute Of Technology |
Methods and compositions for rna-guided genetic circuits
|
|
EP3579858A4
(en)
|
2017-02-07 |
2020-12-23 |
The Regents of The University of California |
GENE THERAPY AGAINST HAPLOINSUFFICIENCY
|
|
US11866699B2
(en)
|
2017-02-10 |
2024-01-09 |
University Of Washington |
Genome editing reagents and their use
|
|
IT201700016321A1
(it)
|
2017-02-14 |
2018-08-14 |
Univ Degli Studi Di Trento |
Mutanti di cas9 ad alta specificita' e loro applicazioni.
|
|
WO2018152197A1
(en)
|
2017-02-15 |
2018-08-23 |
Massachusetts Institute Of Technology |
Dna writers, molecular recorders and uses thereof
|
|
WO2018149915A1
(en)
|
2017-02-15 |
2018-08-23 |
Keygene N.V. |
Methods of targeted genetic alteration in plant cells
|
|
CN106957855B
(zh)
|
2017-02-16 |
2020-04-17 |
上海市农业科学院 |
使用CRISPR/Cas9技术靶向敲除水稻矮杆基因SD1的方法
|
|
WO2018152418A1
(en)
|
2017-02-17 |
2018-08-23 |
Temple University - Of The Commonwealth System Of Higher Education |
Gene editing therapy for hiv infection via dual targeting of hiv genome and ccr5
|
|
EA201991849A1
(ru)
|
2017-02-20 |
2020-03-23 |
Институте Оф Генетисс Анд Девелопментал Биологй. Чинесе Асадемй Оф Ссиенсес |
Система и способ редактирования генома
|
|
US20200040061A1
(en)
|
2017-02-22 |
2020-02-06 |
Crispr Therapeutics Ag |
Materials and methods for treatment of early onset parkinson's disease (park1) and other synuclein, alpha (snca) gene related conditions or disorders
|
|
US11407997B2
(en)
|
2017-02-22 |
2022-08-09 |
Crispr Therapeutics Ag |
Materials and methods for treatment of primary hyperoxaluria type 1 (PH1) and other alanine-glyoxylate aminotransferase (AGXT) gene related conditions or disorders
|
|
US20190365929A1
(en)
|
2017-02-22 |
2019-12-05 |
Crispr Therapeutics Ag |
Materials and methods for treatment of dystrophic epidermolysis bullosa (deb) and other collagen type vii alpha 1 chain (col7a1) gene related conditions or disorders
|
|
WO2018156372A1
(en)
|
2017-02-22 |
2018-08-30 |
The Regents Of The University Of California |
Genetically modified non-human animals and products thereof
|
|
JP7277052B2
(ja)
|
2017-02-22 |
2023-05-18 |
クリスパー セラピューティクス アーゲー |
プロタンパク質転換酵素サブチリシン/ケキシン9型(pcsk9)関連障害の処置のための組成物および方法
|
|
US20200216857A1
(en)
|
2017-02-22 |
2020-07-09 |
Crispr Therapeutics Ag |
Materials and methods for treatment of spinocerebellar ataxia type 2 (sca2) and other spinocerebellar ataxia type 2 protein (atxn2) gene related conditions or disorders
|
|
US11920148B2
(en)
|
2017-02-22 |
2024-03-05 |
Crispr Therapeutics Ag |
Compositions and methods for gene editing
|
|
US11559588B2
(en)
|
2017-02-22 |
2023-01-24 |
Crispr Therapeutics Ag |
Materials and methods for treatment of Spinocerebellar Ataxia Type 1 (SCA1) and other Spinocerebellar Ataxia Type 1 Protein (ATXN1) gene related conditions or disorders
|
|
US20200095579A1
(en)
|
2017-02-22 |
2020-03-26 |
Crispr Therapeutics Ag |
Materials and methods for treatment of merosin-deficient cogenital muscular dystrophy (mdcmd) and other laminin, alpha 2 (lama2) gene related conditions or disorders
|
|
CN106868031A
(zh)
|
2017-02-24 |
2017-06-20 |
北京大学 |
一种基于分级组装的多个sgRNA串联并行表达的克隆方法及应用
|
|
US20200010903A1
(en)
|
2017-03-03 |
2020-01-09 |
Yale University |
AAV-Mediated Direct In vivo CRISPR Screen in Glioblastoma
|
|
US11111492B2
(en)
|
2017-03-06 |
2021-09-07 |
Florida State University Research Foundation, Inc. |
Genome engineering methods using a cytosine-specific Cas9
|
|
US11898179B2
(en)
|
2017-03-09 |
2024-02-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
|
WO2018165631A1
(en)
|
2017-03-09 |
2018-09-13 |
President And Fellows Of Harvard College |
Cancer vaccine
|
|
JP2020510439A
(ja)
|
2017-03-10 |
2020-04-09 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
シトシンからグアニンへの塩基編集因子
|
|
US11332727B2
(en)
|
2017-03-14 |
2022-05-17 |
The Regents Of The University Of California |
Method for reducing an immune response by administering an immune evading adeno-associated AAV8 or AAVDJ viral vector
|
|
CN106978428A
(zh)
|
2017-03-15 |
2017-07-25 |
上海吐露港生物科技有限公司 |
一种Cas蛋白特异结合靶标DNA、调控靶标基因转录的方法及试剂盒
|
|
CN111108220B
(zh)
|
2017-03-15 |
2024-11-19 |
博德研究所 |
用于病毒检测的基于crispr效应系统的诊断
|
|
CN106906242A
(zh)
|
2017-03-16 |
2017-06-30 |
重庆高圣生物医药有限责任公司 |
一种提高CRIPSR/Cas9靶向敲除基因产生非同源性末端接合效率的方法
|
|
CA3057330A1
(en)
|
2017-03-21 |
2018-09-27 |
Anthony P. Shuber |
Treating cancer with cas endonuclease complexes
|
|
GB2575930A
(en)
|
2017-03-23 |
2020-01-29 |
Harvard College |
Nucleobase editors comprising nucleic acid programmable DNA binding proteins
|
|
CN107012213A
(zh)
|
2017-03-24 |
2017-08-04 |
南开大学 |
结直肠癌的生物标记物
|
|
CA3084252A1
(en)
|
2017-03-28 |
2018-10-04 |
Caribou Biosciences, Inc. |
Crispr-associated (cas) protein
|
|
CN106947780A
(zh)
|
2017-03-28 |
2017-07-14 |
扬州大学 |
一种兔mstn基因的编辑方法
|
|
CN106906240A
(zh)
|
2017-03-29 |
2017-06-30 |
浙江大学 |
运用CRISPR‑Cas9系统敲除大麦VE合成通路中的关键基因HPT的方法
|
|
CN110892069B
(zh)
|
2017-03-30 |
2024-02-09 |
国立大学法人京都大学 |
基于基因组编辑的外显子跳跃诱导方法
|
|
CN108660161B
(zh)
|
2017-03-31 |
2023-05-09 |
中国科学院脑科学与智能技术卓越创新中心 |
基于CRISPR/Cas9技术的制备无嵌合基因敲除动物的方法
|
|
CN107058358B
(zh)
|
2017-04-01 |
2020-06-09 |
中国科学院微生物研究所 |
一种双spacer序列识别切割CRISPR-Cas9载体构建及其在疣孢菌中的应用
|
|
US9938288B1
(en)
|
2017-04-05 |
2018-04-10 |
President And Fellows Of Harvard College |
Macrocyclic compound and uses thereof
|
|
CN106967726B
(zh)
|
2017-04-05 |
2020-12-29 |
华南农业大学 |
一种创建亚洲栽培稻与非洲栽培稻种间杂种亲和系的方法和应用
|
|
CN107142282A
(zh)
|
2017-04-06 |
2017-09-08 |
中山大学 |
一种利用CRISPR/Cas9在哺乳动物细胞中实现大片段DNA定点整合的方法
|
|
CN107034229A
(zh)
|
2017-04-07 |
2017-08-11 |
江苏贝瑞利生物科技有限公司 |
一种植物中高效筛选CRISPR/CAS9基因编辑系统候选sgRNA系统及应用
|
|
WO2018189184A1
(en)
|
2017-04-11 |
2018-10-18 |
Roche Diagnostics Gmbh |
Mutant reverse transcriptase with increased thermal stability as well as products, methods and uses involving the same
|
|
CN107058320B
(zh)
|
2017-04-12 |
2019-08-02 |
南开大学 |
Il7r基因缺失斑马鱼突变体的制备及其应用
|
|
US11840711B2
(en)
|
2017-04-12 |
2023-12-12 |
The Broad Institute, Inc. |
Type VI CRISPR orthologs and systems
|
|
CN106916852B
(zh)
|
2017-04-13 |
2020-12-04 |
上海科技大学 |
一种碱基编辑系统及其构建和应用方法
|
|
CN108728476A
(zh)
|
2017-04-14 |
2018-11-02 |
复旦大学 |
一种利用crispr系统产生多样性抗体文库的方法
|
|
CN107298701B
(zh)
|
2017-04-18 |
2020-10-30 |
上海大学 |
玉米转录因子ZmbZIP22及其应用
|
|
CN106957844A
(zh)
|
2017-04-20 |
2017-07-18 |
华侨大学 |
一种能有效敲除HTLV‑1病毒基因组的CRISPR/Cas9的gRNA序列
|
|
MX2019012567A
(es)
|
2017-04-20 |
2020-02-13 |
Egenesis Inc |
Metodos para generar animales geneticamente modificados.
|
|
EP4481049A3
(en)
|
2017-04-21 |
2025-03-19 |
The General Hospital Corporation |
Variants of cpf1 (cas12a) with altered pam specificity
|
|
US11773409B2
(en)
|
2017-04-21 |
2023-10-03 |
The Board Of Trustees Of The Leland Stanford Junior University |
CRISPR/Cas 9-mediated integration of polynucleotides by sequential homologous recombination of AAV donor vectors
|
|
EP3615665B1
(en)
|
2017-04-24 |
2025-11-26 |
International N&H Denmark ApS |
Novel anti-crispr genes and proteins and methods of use
|
|
CN107043775B
(zh)
|
2017-04-24 |
2020-06-16 |
中国农业科学院生物技术研究所 |
一种能促进棉花侧根发育的sgRNA及其应用
|
|
CN206970581U
(zh)
|
2017-04-26 |
2018-02-06 |
重庆威斯腾生物医药科技有限责任公司 |
一种用于辅助CRISPR/cas9基因敲除的试剂盒
|
|
US20180312822A1
(en)
|
2017-04-26 |
2018-11-01 |
10X Genomics, Inc. |
Mmlv reverse transcriptase variants
|
|
WO2018197020A1
(en)
|
2017-04-27 |
2018-11-01 |
Novozymes A/S |
Genome editing by crispr-cas9 using short donor oligonucleotides
|
|
US20200407737A1
(en)
|
2017-05-03 |
2020-12-31 |
KWS SAAT SE & Co. KGaA |
Use of crispr-cas endonucleases for plant genome engineering
|
|
WO2018204493A1
(en)
|
2017-05-04 |
2018-11-08 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for gene editing in t cells using crispr/cpf1
|
|
CN107012174A
(zh)
|
2017-05-04 |
2017-08-04 |
昆明理工大学 |
CRISPR/Cas9技术在获得家蚕锌指蛋白基因突变体中的应用
|
|
CN107254485A
(zh)
|
2017-05-08 |
2017-10-17 |
南京农业大学 |
一种能够快速构建植物基因定点敲除载体的新反应体系
|
|
WO2018208755A1
(en)
|
2017-05-09 |
2018-11-15 |
The Regents Of The University Of California |
Compositions and methods for tagging target proteins in proximity to a nucleotide sequence of interest
|
|
CN107129999A
(zh)
|
2017-05-09 |
2017-09-05 |
福建省农业科学院畜牧兽医研究所 |
利用稳转CRISPR/Cas9系统对病毒基因组进行靶向编辑的方法
|
|
EP3622070A2
(en)
|
2017-05-10 |
2020-03-18 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
|
EP3622062A4
(en)
|
2017-05-10 |
2020-10-14 |
The Regents of the University of California |
DIRECTED EDITING OF CELLULAR RNA BY NUCLEAR ADMINISTRATION OF CRISPR / CAS9
|
|
CN107130000B
(zh)
|
2017-05-12 |
2019-12-17 |
浙江卫未生物医药科技有限公司 |
一种同时敲除KRAS基因和EGFR基因的CRISPR-Cas9系统及其应用
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
CN106947750B
(zh)
|
2017-05-16 |
2020-12-08 |
上海交通大学 |
一种Cas9核酸酶Q920P及其用途
|
|
CN106957830B
(zh)
|
2017-05-16 |
2020-12-25 |
上海交通大学 |
一种Cas9核酸酶ΔF916及其用途
|
|
CN106987570A
(zh)
|
2017-05-16 |
2017-07-28 |
上海交通大学 |
一种Cas9核酸酶R780A及其用途
|
|
CN106957831B
(zh)
|
2017-05-16 |
2021-03-12 |
上海交通大学 |
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
|
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|
|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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(zh)
|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
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(en)
|
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The Broad Institute, Inc. |
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|
|
WO2019005886A1
(en)
|
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|
|
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(zh)
|
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|
|
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(zh)
|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
WO2019010384A1
(en)
|
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|
|
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|
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|
|
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|
|
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|
|
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|
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|
|
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|
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|
|
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|
|
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|
|
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|
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|
|
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|
|
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(en)
|
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|
|
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|
|
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|
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|
|
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|
|
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|
|
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|
|
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|
|
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|
|
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|
|
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|
|
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|
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|
|
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|
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|
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|
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|
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|
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|
|
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|
|
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|
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|
|
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|
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|
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|
|
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|
|
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|
|
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|
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|
|
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|
|
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|
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|
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
|
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|
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|
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|
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|
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|
|
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|
|
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|
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|
|
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(en)
|
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|
|
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|
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|
|
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|
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|
|
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|
|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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(en)
|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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(zh)
|
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|
|
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(zh)
|
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|
|
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(zh)
|
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|
|
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(en)
|
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|
|
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(zh)
|
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|
|
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(zh)
|
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|
|
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(zh)
|
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|
|
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(zh)
|
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|
|
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(en)
|
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|
|
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(zh)
|
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|
|
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(en)
|
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|
|
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(en)
|
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2021-03-11 |
Flagship Pioneering Innovations Vi, Llc |
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|
|
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(en)
|
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2020-03-12 |
The Broad Institute, Inc. |
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|
|
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(en)
|
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The Broad Institute, Inc. |
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|
|
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(en)
|
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The Broad Institute, Inc. |
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|
|
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(en)
|
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The Broad Institute, Inc. |
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|
|
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(zh)
|
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|
|
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(en)
|
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The Broad Institute, Inc. |
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|
|
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(en)
|
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The Broad Institute, Inc. |
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|
|
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(en)
|
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The Broad Institute, Inc. |
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|
|
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(en)
|
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The Broad Institute, Inc. |
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|
|
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(en)
|
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The Broad Institute, Inc. |
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|
|
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(en)
|
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The Broad Institute, Inc. |
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|
|
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(en)
|
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The Broad Institute, Inc. |
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|
|
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(en)
|
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2020-10-15 |
The Broad Institute, Inc. |
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|
|
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(en)
|
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The Broad Institute, Inc. |
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|