DK1506288T3 - Aktiveringsinduceret deaminase (aid) - Google Patents

Aktiveringsinduceret deaminase (aid)

Info

Publication number
DK1506288T3
DK1506288T3 DK03722838.4T DK03722838T DK1506288T3 DK 1506288 T3 DK1506288 T3 DK 1506288T3 DK 03722838 T DK03722838 T DK 03722838T DK 1506288 T3 DK1506288 T3 DK 1506288T3
Authority
DK
Denmark
Prior art keywords
activation
aid
induced deaminase
deaminase
induced
Prior art date
Application number
DK03722838.4T
Other languages
English (en)
Inventor
S C Petesersen-Mahr
R S Harris
M S Neuberger
R C L Beale
Original Assignee
Medical Res Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0210755A external-priority patent/GB0210755D0/en
Priority claimed from GB0213751A external-priority patent/GB0213751D0/en
Priority claimed from GB0217519A external-priority patent/GB0217519D0/en
Application filed by Medical Res Council filed Critical Medical Res Council
Application granted granted Critical
Publication of DK1506288T3 publication Critical patent/DK1506288T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK03722838.4T 2002-05-10 2003-05-09 Aktiveringsinduceret deaminase (aid) DK1506288T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0210755A GB0210755D0 (en) 2002-05-10 2002-05-10 Aid
GB0213751A GB0213751D0 (en) 2002-06-14 2002-06-14 Aid
GB0217519A GB0217519D0 (en) 2002-07-29 2002-07-29 Aid
PCT/GB2003/002002 WO2003095636A2 (en) 2002-05-10 2003-05-09 Activation induced deaminase (aid)

Publications (1)

Publication Number Publication Date
DK1506288T3 true DK1506288T3 (da) 2013-07-22

Family

ID=29424146

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03722838.4T DK1506288T3 (da) 2002-05-10 2003-05-09 Aktiveringsinduceret deaminase (aid)

Country Status (6)

Country Link
US (3) US7820442B2 (da)
EP (1) EP1506288B1 (da)
AU (1) AU2003229998A1 (da)
DK (1) DK1506288T3 (da)
ES (1) ES2421596T3 (da)
WO (1) WO2003095636A2 (da)

Families Citing this family (48)

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Publication number Priority date Publication date Assignee Title
US7122339B2 (en) * 1998-10-09 2006-10-17 Medical Research Council Method for generating diversity
AU2003229998A1 (en) * 2002-05-10 2003-11-11 Medical Research Council Activation induced deaminase (aid)
DE60335191D1 (de) 2002-07-30 2011-01-13 Japan Science & Tech Agency Verfahren zur förderung der homologen rekombination somatischer zellen und verfahren zur konstruktion eines spezifischen antikörpers
US7220554B2 (en) 2003-05-23 2007-05-22 Oregon Health And Science University Methods for identifying inhibitors
EP1895835B1 (en) 2005-06-24 2014-02-12 Recombinetics, Inc. Using cytosine deaminases to diminish retroelement transfer from pigs to humans
GB0607063D0 (en) * 2006-04-07 2006-05-17 Cellcentric Ltd Compositions and methods for epigenetic modification of nucleic acid sequences in vivo
EP2126105A4 (en) * 2007-02-20 2010-11-03 Anaptysbio Inc SOMATIC HYPERPERMUTATION SYSTEMS
EP2098536A1 (en) 2008-03-05 2009-09-09 4-Antibody AG Isolation and identification of antigen- or ligand-specific binding proteins
US9023594B2 (en) 2008-09-05 2015-05-05 President And Fellows Of Harvard College Continuous directed evolution of proteins and nucleic acids
CN102482639B (zh) * 2009-04-03 2016-01-06 医学研究会 活化诱导胞苷脱氨酶(aid)突变体及使用方法
US20120309011A1 (en) * 2009-11-02 2012-12-06 Salk Institute For Biological Studies Targeting of modifying enzymes for protein evolution
US20110104787A1 (en) * 2009-11-05 2011-05-05 President And Fellows Of Harvard College Fusion Peptides That Bind to and Modify Target Nucleic Acid Sequences
WO2012063048A1 (en) 2010-11-08 2012-05-18 Kymab Limited Cells & vertebrates for enhanced somatic hypermutation and class switch recombination
EP3202903B1 (en) 2010-12-22 2020-02-12 President and Fellows of Harvard College Continuous directed evolution
CA2853829C (en) 2011-07-22 2023-09-26 President And Fellows Of Harvard College Evaluation and improvement of nuclease cleavage specificity
GB201223053D0 (en) 2012-12-20 2013-02-06 Medical Res Council Receptor
US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
US9228207B2 (en) 2013-09-06 2016-01-05 President And Fellows Of Harvard College Switchable gRNAs comprising aptamers
US10179911B2 (en) 2014-01-20 2019-01-15 President And Fellows Of Harvard College Negative selection and stringency modulation in continuous evolution systems
WO2015138620A1 (en) * 2014-03-11 2015-09-17 University Of Washington Restricting nuclear protein to specific phases of the cell cycle
US10077453B2 (en) 2014-07-30 2018-09-18 President And Fellows Of Harvard College CAS9 proteins including ligand-dependent inteins
US10920208B2 (en) 2014-10-22 2021-02-16 President And Fellows Of Harvard College Evolution of proteases
US10308930B2 (en) 2014-11-06 2019-06-04 Albert Einstein College Of Medicine Methods to accelerate antibody diversification
WO2016164886A1 (en) * 2015-04-09 2016-10-13 Health Research, Inc. Apobec3a cytidine deaminase induced rna editing
WO2016168631A1 (en) * 2015-04-17 2016-10-20 President And Fellows Of Harvard College Vector-based mutagenesis system
AU2016278741B2 (en) * 2015-06-15 2018-12-20 Unilever Plc Food product
US10392674B2 (en) 2015-07-22 2019-08-27 President And Fellows Of Harvard College Evolution of site-specific recombinases
US11524983B2 (en) 2015-07-23 2022-12-13 President And Fellows Of Harvard College Evolution of Bt toxins
US10612011B2 (en) 2015-07-30 2020-04-07 President And Fellows Of Harvard College Evolution of TALENs
IL294014B2 (en) 2015-10-23 2024-07-01 Harvard College Nucleobase editors and their uses
IL308426A (en) 2016-08-03 2024-01-01 Harvard College Adenosine nuclear base editors and their uses
US11661590B2 (en) 2016-08-09 2023-05-30 President And Fellows Of Harvard College Programmable CAS9-recombinase fusion proteins and uses thereof
US11542509B2 (en) 2016-08-24 2023-01-03 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
SG11201903089RA (en) 2016-10-14 2019-05-30 Harvard College Aav delivery of nucleobase editors
WO2018119359A1 (en) 2016-12-23 2018-06-28 President And Fellows Of Harvard College Editing of ccr5 receptor gene to protect against hiv infection
US11898179B2 (en) 2017-03-09 2024-02-13 President And Fellows Of Harvard College Suppression of pain by gene editing
EP3592777A1 (en) 2017-03-10 2020-01-15 President and Fellows of Harvard College Cytosine to guanine base editor
JP7191388B2 (ja) 2017-03-23 2022-12-19 プレジデント アンド フェローズ オブ ハーバード カレッジ 核酸によってプログラム可能なｄｎａ結合蛋白質を含む核酸塩基編集因子
US11560566B2 (en) 2017-05-12 2023-01-24 President And Fellows Of Harvard College Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
US11447809B2 (en) 2017-07-06 2022-09-20 President And Fellows Of Harvard College Evolution of tRNA synthetases
CN111801345A (zh) 2017-07-28 2020-10-20 哈佛大学的校长及成员们 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
WO2019040935A1 (en) 2017-08-25 2019-02-28 President And Fellows Of Harvard College EVOLUTION OF PEPTIDASES BONT
US11319532B2 (en) 2017-08-30 2022-05-03 President And Fellows Of Harvard College High efficiency base editors comprising Gam
WO2019056002A1 (en) 2017-09-18 2019-03-21 President And Fellows Of Harvard College CONTINUOUS EVOLUTION FOR STABILIZED PROTEINS
CN111757937A (zh) 2017-10-16 2020-10-09 布罗德研究所股份有限公司 腺苷碱基编辑器的用途
WO2019241649A1 (en) 2018-06-14 2019-12-19 President And Fellows Of Harvard College Evolution of cytidine deaminases
WO2020191243A1 (en) 2019-03-19 2020-09-24 The Broad Institute, Inc. Methods and compositions for editing nucleotide sequences
DE112021002672T5 (de) 2020-05-08 2023-04-13 President And Fellows Of Harvard College Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2732348B1 (fr) * 1995-03-31 1997-04-30 Rhone Poulenc Rorer Sa Systeme d'expression conditionnel
EP1174509A4 (en) 1999-03-29 2003-10-22 Kansai Tech Licensing Org Co NEW CYTIDINE DESAMINASE
US20050095712A1 (en) * 2002-01-17 2005-05-05 Alberto Martin Mutations caused by activation-induced cytidine deaminase
AU2003229998A1 (en) * 2002-05-10 2003-11-11 Medical Research Council Activation induced deaminase (aid)

Also Published As

Publication number Publication date
ES2421596T3 (es) 2013-09-04
WO2003095636A2 (en) 2003-11-20
WO2003095636A3 (en) 2004-02-12
AU2003229998A8 (en) 2003-11-11
US20060019262A1 (en) 2006-01-26
US8288160B2 (en) 2012-10-16
EP1506288B1 (en) 2013-04-17
US20110136922A1 (en) 2011-06-09
US7820442B2 (en) 2010-10-26
US20130059931A1 (en) 2013-03-07
EP1506288A2 (en) 2005-02-16
AU2003229998A1 (en) 2003-11-11

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