DK1506288T3 - Aktiveringsinduceret deaminase (aid) - Google Patents

Aktiveringsinduceret deaminase (aid)

Info

Publication number
DK1506288T3
DK1506288T3 DK03722838.4T DK03722838T DK1506288T3 DK 1506288 T3 DK1506288 T3 DK 1506288T3 DK 03722838 T DK03722838 T DK 03722838T DK 1506288 T3 DK1506288 T3 DK 1506288T3
Authority
DK
Denmark
Prior art keywords
activation
aid
induced deaminase
deaminase
induced
Prior art date
Application number
DK03722838.4T
Other languages
English (en)
Inventor
S C Petesersen-Mahr
R S Harris
M S Neuberger
R C L Beale
Original Assignee
Medical Res Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0210755A external-priority patent/GB0210755D0/en
Priority claimed from GB0213751A external-priority patent/GB0213751D0/en
Priority claimed from GB0217519A external-priority patent/GB0217519D0/en
Application filed by Medical Res Council filed Critical Medical Res Council
Application granted granted Critical
Publication of DK1506288T3 publication Critical patent/DK1506288T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK03722838.4T 2002-05-10 2003-05-09 Aktiveringsinduceret deaminase (aid) DK1506288T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0210755A GB0210755D0 (en) 2002-05-10 2002-05-10 Aid
GB0213751A GB0213751D0 (en) 2002-06-14 2002-06-14 Aid
GB0217519A GB0217519D0 (en) 2002-07-29 2002-07-29 Aid
PCT/GB2003/002002 WO2003095636A2 (en) 2002-05-10 2003-05-09 Activation induced deaminase (aid)

Publications (1)

Publication Number Publication Date
DK1506288T3 true DK1506288T3 (da) 2013-07-22

Family

ID=29424146

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03722838.4T DK1506288T3 (da) 2002-05-10 2003-05-09 Aktiveringsinduceret deaminase (aid)

Country Status (6)

Country Link
US (3) US7820442B2 (da)
EP (1) EP1506288B1 (da)
AU (1) AU2003229998A1 (da)
DK (1) DK1506288T3 (da)
ES (1) ES2421596T3 (da)
WO (1) WO2003095636A2 (da)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7122339B2 (en) * 1998-10-09 2006-10-17 Medical Research Council Method for generating diversity
ES2421596T3 (es) * 2002-05-10 2013-09-04 Medical Res Council Desaminasa inducida por activación (AID)
DE60335191D1 (de) 2002-07-30 2011-01-13 Japan Science & Tech Agency Verfahren zur förderung der homologen rekombination somatischer zellen und verfahren zur konstruktion eines spezifischen antikörpers
ATE388961T1 (de) 2003-05-23 2008-03-15 Univ Oregon Health & Science Verfahren zur identifikation von inhibitoren
AU2006262020B8 (en) 2005-06-24 2011-02-17 Recombinetics, Inc. Using cytosine deaminases to diminish retroelement transfer from pigs to humans
GB0607063D0 (en) * 2006-04-07 2006-05-17 Cellcentric Ltd Compositions and methods for epigenetic modification of nucleic acid sequences in vivo
WO2008103475A1 (en) * 2007-02-20 2008-08-28 Anaptysbio, Inc. Somatic hypermutation systems
EP2098536A1 (en) 2008-03-05 2009-09-09 4-Antibody AG Isolation and identification of antigen- or ligand-specific binding proteins
US9023594B2 (en) 2008-09-05 2015-05-05 President And Fellows Of Harvard College Continuous directed evolution of proteins and nucleic acids
EP2414507B1 (en) * 2009-04-03 2014-07-02 Medical Research Council Mutants of activation-induced cytidine deaminase (aid) and methods of use
US20120309011A1 (en) * 2009-11-02 2012-12-06 Salk Institute For Biological Studies Targeting of modifying enzymes for protein evolution
US20110104787A1 (en) * 2009-11-05 2011-05-05 President And Fellows Of Harvard College Fusion Peptides That Bind to and Modify Target Nucleic Acid Sequences
WO2012063048A1 (en) 2010-11-08 2012-05-18 Kymab Limited Cells & vertebrates for enhanced somatic hypermutation and class switch recombination
US9394537B2 (en) 2010-12-22 2016-07-19 President And Fellows Of Harvard College Continuous directed evolution
GB201223053D0 (en) 2012-12-20 2013-02-06 Medical Res Council Receptor
US9163284B2 (en) 2013-08-09 2015-10-20 President And Fellows Of Harvard College Methods for identifying a target site of a Cas9 nuclease
US9340799B2 (en) 2013-09-06 2016-05-17 President And Fellows Of Harvard College MRNA-sensing switchable gRNAs
EP3097196B1 (en) 2014-01-20 2019-09-11 President and Fellows of Harvard College Negative selection and stringency modulation in continuous evolution systems
US20160369258A1 (en) * 2014-03-11 2016-12-22 University Of Washington Restricting nuclear protein to specific phases of the cell cycle
US10077453B2 (en) 2014-07-30 2018-09-18 President And Fellows Of Harvard College CAS9 proteins including ligand-dependent inteins
US10920208B2 (en) 2014-10-22 2021-02-16 President And Fellows Of Harvard College Evolution of proteases
US10308930B2 (en) 2014-11-06 2019-06-04 Albert Einstein College Of Medicine Methods to accelerate antibody diversification
US20180072793A1 (en) * 2015-04-09 2018-03-15 Health Research, Inc. Apobec3a cytidine deaminase induced rna editing
US11299729B2 (en) 2015-04-17 2022-04-12 President And Fellows Of Harvard College Vector-based mutagenesis system
ES2714157T3 (es) * 2015-06-15 2019-05-27 Unilever Nv Producto alimenticio
US10392674B2 (en) 2015-07-22 2019-08-27 President And Fellows Of Harvard College Evolution of site-specific recombinases
US11524983B2 (en) 2015-07-23 2022-12-13 President And Fellows Of Harvard College Evolution of Bt toxins
WO2017019895A1 (en) 2015-07-30 2017-02-02 President And Fellows Of Harvard College Evolution of talens
IL310721A (en) 2015-10-23 2024-04-01 Harvard College Nucleobase editors and their uses
CA3032699A1 (en) 2016-08-03 2018-02-08 President And Fellows Of Harvard College Adenosine nucleobase editors and uses thereof
AU2017308889B2 (en) 2016-08-09 2023-11-09 President And Fellows Of Harvard College Programmable Cas9-recombinase fusion proteins and uses thereof
WO2018039438A1 (en) 2016-08-24 2018-03-01 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
CN110214180A (zh) 2016-10-14 2019-09-06 哈佛大学的校长及成员们 核碱基编辑器的aav递送
WO2018119359A1 (en) 2016-12-23 2018-06-28 President And Fellows Of Harvard College Editing of ccr5 receptor gene to protect against hiv infection
EP3592853A1 (en) 2017-03-09 2020-01-15 President and Fellows of Harvard College Suppression of pain by gene editing
US11542496B2 (en) 2017-03-10 2023-01-03 President And Fellows Of Harvard College Cytosine to guanine base editor
CN110914426A (zh) 2017-03-23 2020-03-24 哈佛大学的校长及成员们 包含核酸可编程dna结合蛋白的核碱基编辑器
WO2018209320A1 (en) 2017-05-12 2018-11-15 President And Fellows Of Harvard College Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
WO2019010164A1 (en) 2017-07-06 2019-01-10 President And Fellows Of Harvard College EVOLUTION OF ARNT SYNTHÉTASES
CN111801345A (zh) 2017-07-28 2020-10-20 哈佛大学的校长及成员们 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
US11319532B2 (en) 2017-08-30 2022-05-03 President And Fellows Of Harvard College High efficiency base editors comprising Gam
US11624130B2 (en) 2017-09-18 2023-04-11 President And Fellows Of Harvard College Continuous evolution for stabilized proteins
AU2018352592A1 (en) 2017-10-16 2020-06-04 Beam Therapeutics, Inc. Uses of adenosine base editors
WO2019241649A1 (en) 2018-06-14 2019-12-19 President And Fellows Of Harvard College Evolution of cytidine deaminases
AU2020242032A1 (en) 2019-03-19 2021-10-07 Massachusetts Institute Of Technology Methods and compositions for editing nucleotide sequences
CA3177481A1 (en) 2020-05-08 2021-11-11 David R. Liu Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2732348B1 (fr) * 1995-03-31 1997-04-30 Rhone Poulenc Rorer Sa Systeme d'expression conditionnel
EP1174509A4 (en) * 1999-03-29 2003-10-22 Kansai Tech Licensing Org Co NEW CYTIDINE DESAMINASE
WO2003061363A2 (en) * 2002-01-17 2003-07-31 Albert Einstein College Of Medicine Of Yeshiva University Mutations caused by activation-induced cytidine deaminase
ES2421596T3 (es) * 2002-05-10 2013-09-04 Medical Res Council Desaminasa inducida por activación (AID)

Also Published As

Publication number Publication date
WO2003095636A2 (en) 2003-11-20
AU2003229998A1 (en) 2003-11-11
WO2003095636A3 (en) 2004-02-12
ES2421596T3 (es) 2013-09-04
US20110136922A1 (en) 2011-06-09
EP1506288A2 (en) 2005-02-16
US20130059931A1 (en) 2013-03-07
AU2003229998A8 (en) 2003-11-11
EP1506288B1 (en) 2013-04-17
US20060019262A1 (en) 2006-01-26
US7820442B2 (en) 2010-10-26
US8288160B2 (en) 2012-10-16

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