DE60335191D1 - Verfahren zur förderung der homologen rekombination somatischer zellen und verfahren zur konstruktion eines spezifischen antikörpers - Google Patents

Verfahren zur förderung der homologen rekombination somatischer zellen und verfahren zur konstruktion eines spezifischen antikörpers

Info

Publication number
DE60335191D1
DE60335191D1 DE60335191T DE60335191T DE60335191D1 DE 60335191 D1 DE60335191 D1 DE 60335191D1 DE 60335191 T DE60335191 T DE 60335191T DE 60335191 T DE60335191 T DE 60335191T DE 60335191 D1 DE60335191 D1 DE 60335191D1
Authority
DE
Germany
Prior art keywords
homologous recombination
antibody
constructing
specific antibody
somatic cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60335191T
Other languages
English (en)
Inventor
Kunihiro Ohta
Hidetaka Seo
Takehiko Shibata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chiome Bioscience Inc Tokyo Jp
Riken Wako Saitama Jp
Original Assignee
Japan Science and Technology Agency
RIKEN Institute of Physical and Chemical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Science and Technology Agency, RIKEN Institute of Physical and Chemical Research filed Critical Japan Science and Technology Agency
Application granted granted Critical
Publication of DE60335191D1 publication Critical patent/DE60335191D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/23—Immunoglobulins specific features characterized by taxonomic origin from birds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60335191T 2002-07-30 2003-07-28 Verfahren zur förderung der homologen rekombination somatischer zellen und verfahren zur konstruktion eines spezifischen antikörpers Expired - Lifetime DE60335191D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002221232 2002-07-30
PCT/JP2003/009563 WO2004011644A1 (ja) 2002-07-30 2003-07-28 体細胞相同組換えの促進方法及び特異的抗体の作製方法

Publications (1)

Publication Number Publication Date
DE60335191D1 true DE60335191D1 (de) 2011-01-13

Family

ID=31184846

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60335191T Expired - Lifetime DE60335191D1 (de) 2002-07-30 2003-07-28 Verfahren zur förderung der homologen rekombination somatischer zellen und verfahren zur konstruktion eines spezifischen antikörpers

Country Status (7)

Country Link
US (2) US7776599B2 (de)
EP (1) EP1536004B1 (de)
JP (1) JP4214234B2 (de)
CN (1) CN100379862C (de)
AT (1) ATE490314T1 (de)
DE (1) DE60335191D1 (de)
WO (1) WO2004011644A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004085644A2 (en) * 2003-03-26 2004-10-07 Basf Plant Science Gmbh Method for producing recombinant organisms
EP1811039A4 (de) * 2004-11-08 2009-08-05 Riken Verfahren zum effizienten screening von zur spezifischen ligandenbindung fähigem protein
JP4482693B2 (ja) * 2005-08-29 2010-06-16 国立大学法人 岡山大学 抗体産生細胞の特異的選択方法
WO2007049567A1 (ja) * 2005-10-24 2007-05-03 Kyowa Hakko Kogyo Co., Ltd. 物質の製造方法
JP2009291073A (ja) * 2006-09-22 2009-12-17 Chiome Bioscience Inc 抗体のクラスを変換する方法
JP2008099602A (ja) * 2006-10-19 2008-05-01 Institute Of Physical & Chemical Research 抗体遺伝子の可変領域における変異部位の分布状況の調節法
JP5537420B2 (ja) * 2007-05-31 2014-07-02 ユニヴァーシティ オブ ワシントン 標的遺伝子の誘導性変異誘発
US9090672B2 (en) 2008-12-05 2015-07-28 Chiome Bioscience Inc. Method for producing antibody directed against protein expressed on cell surface
US8901044B2 (en) * 2009-05-13 2014-12-02 Riken Method to prepare magnetic beads conjugated with small compounds
JP5158816B2 (ja) * 2009-10-19 2013-03-06 国立大学法人 東京大学 キメラ抗体の一段階作製方法
JP6156144B2 (ja) 2011-09-21 2017-07-05 富士レビオ株式会社 親和性複合体に対する抗体
CA2865506C (en) 2012-03-15 2021-07-06 Omeros Corporation Composition and method for diversification of target sequences
US20160187325A1 (en) 2013-08-21 2016-06-30 Fujirebio Inc. Method and kit for measuring modified nucleobase using heterogeneous nucleic acid probe
US10107802B2 (en) 2013-08-21 2018-10-23 Fujirebio Inc. Method for measuring modified nucleobase using solid phase probe, and kit for same
JP6451634B2 (ja) 2013-08-21 2019-01-16 富士レビオ株式会社 吸収剤ポリヌクレオチドを用いた修飾核酸塩基の測定方法およびそのキット
JP6497323B2 (ja) 2014-01-20 2019-04-10 富士レビオ株式会社 ガイドプローブを用いた修飾核酸塩基の測定方法およびそのためのキット
HUE057708T2 (hu) 2014-05-02 2022-05-28 Chiome Bioscience Inc Sejtek humán antitestek elõállítására
FI3521307T3 (fi) * 2016-09-30 2023-04-03 Chiome Bioscience Inc Menetelmä vasta-aineiden saamiseksi
ES2895641T3 (es) 2017-02-10 2022-02-22 Chiome Bioscience Inc Método para fomentar la diversificación de una región variable de anticuerpos
CN111512154B (zh) 2017-12-25 2022-05-27 富士瑞必欧株式会社 针对大环内酯类免疫抑制剂的血液检测方法
CN118459598A (zh) 2019-12-27 2024-08-09 凯奥目生物科学株式会社 抗cdcp1抗体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2588910T3 (es) 1998-10-09 2016-11-07 Medical Research Council Método para generar diversidad
US7122339B2 (en) 1998-10-09 2006-10-17 Medical Research Council Method for generating diversity
CN1345935A (zh) * 2000-09-26 2002-04-24 上海博德基因开发有限公司 一种新的多肽——人组蛋白去乙酰基酶12.98和编码这种多肽的多核苷酸
AU2003229998A1 (en) 2002-05-10 2003-11-11 Medical Research Council Activation induced deaminase (aid)

Also Published As

Publication number Publication date
JP4214234B2 (ja) 2009-01-28
US20110070650A1 (en) 2011-03-24
US20060183225A1 (en) 2006-08-17
WO2004011644A1 (ja) 2004-02-05
CN100379862C (zh) 2008-04-09
EP1536004B1 (de) 2010-12-01
CN1671842A (zh) 2005-09-21
EP1536004A4 (de) 2006-06-14
US8187884B2 (en) 2012-05-29
JPWO2004011644A1 (ja) 2005-11-24
EP1536004A1 (de) 2005-06-01
ATE490314T1 (de) 2010-12-15
US7776599B2 (en) 2010-08-17

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: CHIOME BIOSCIENCE, INC., TOKYO, JP

Owner name: RIKEN, WAKO, SAITAMA, JP