MX2009003480A - Metodos para mejorar la produccion de anticuerpo. - Google Patents

Metodos para mejorar la produccion de anticuerpo.

Info

Publication number
MX2009003480A
MX2009003480A MX2009003480A MX2009003480A MX2009003480A MX 2009003480 A MX2009003480 A MX 2009003480A MX 2009003480 A MX2009003480 A MX 2009003480A MX 2009003480 A MX2009003480 A MX 2009003480A MX 2009003480 A MX2009003480 A MX 2009003480A
Authority
MX
Mexico
Prior art keywords
antibody
methods
parent antibody
antibody production
fragments
Prior art date
Application number
MX2009003480A
Other languages
English (en)
Inventor
Daniel Tavares
Xiao-Mai Zhou
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of MX2009003480A publication Critical patent/MX2009003480A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2884—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención comprende la elaboración de variantes de anticuerpo, tal como la variante de huC242, o fragmentos del mismo, en donde las variantes son elaboradas por medio de sustitución de uno o más residuos de aminoácido en un anticuerpo padre. Dicha(s) sustitución(es) se efectúa(n) de manera preferible en una secuencia de estructura de marco de región variable del anticuerpo padre que comprende una cadena pesad y una ligera. Como una consecuencia de dicha(s) sustitución(es), los anticuerpos variantes o fragmentos de los mismos muestran síntesis de anticuerpo mejorada cuando son introducidos en una célula huésped en comparación con el anticuerpo padre.
MX2009003480A 2006-10-31 2007-10-30 Metodos para mejorar la produccion de anticuerpo. MX2009003480A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85536106P 2006-10-31 2006-10-31
PCT/US2007/082994 WO2008073598A2 (en) 2006-10-31 2007-10-30 Methods for improving antibody production

Publications (1)

Publication Number Publication Date
MX2009003480A true MX2009003480A (es) 2009-04-15

Family

ID=39512365

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009003480A MX2009003480A (es) 2006-10-31 2007-10-30 Metodos para mejorar la produccion de anticuerpo.

Country Status (10)

Country Link
US (1) US20080138898A1 (es)
EP (1) EP2069379A4 (es)
JP (1) JP2010508043A (es)
CN (1) CN101535332A (es)
AU (1) AU2007333485A1 (es)
BR (1) BRPI0717882A2 (es)
CA (1) CA2667502A1 (es)
IL (1) IL197823A0 (es)
MX (1) MX2009003480A (es)
WO (1) WO2008073598A2 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012520064A (ja) * 2009-03-10 2012-09-06 ディーエスエム アイピー アセッツ ビー．ブイ． ポリペプチドの収量を改良する方法
JP5789949B2 (ja) * 2010-10-05 2015-10-07 東ソー株式会社 改良されたｒｎａポリメラーゼ変異体
US9309322B2 (en) 2010-11-12 2016-04-12 Scott & White Healthcare (Swh) Antibodies to tumor endothelial marker 8
EP3138581B1 (en) 2011-03-17 2019-01-02 The University of Birmingham Re-directed immunotherapy
JP6433889B2 (ja) * 2012-06-15 2018-12-05 ファイザー・インク Ｇｄｆ−８に対する改善された拮抗抗体およびその使用
PL2766048T3 (pl) 2012-10-12 2015-05-29 Medimmune Ltd Pirolobenzodiazepiny i ich koniugaty
US20160031887A1 (en) 2013-03-13 2016-02-04 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
EP3193940A1 (en) 2014-09-10 2017-07-26 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
CN109862919A (zh) 2016-10-11 2019-06-07 免疫医疗有限公司 抗体-药物缀合物联合免疫介导的治疗剂
CN113286616A (zh) 2018-05-23 2021-08-20 Adc治疗有限公司 分子佐剂
EP3897851A2 (en) 2018-12-17 2021-10-27 Revitope Limited Twin immune cell engager
WO2022150740A1 (en) * 2021-01-11 2022-07-14 Board Of Regents, The University Of Texas System Cross-reactive antibodies recognizing the coronavirus spike s2 domain
GB202102396D0 (en) 2021-02-19 2021-04-07 Adc Therapeutics Sa Molecular adjuvant

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
JP2005532395A (ja) * 2002-07-02 2005-10-27 スミスクライン・ビーチャム・コーポレイション 新規な安定処方
WO2004065417A2 (en) * 2003-01-23 2004-08-05 Genentech, Inc. Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture

Also Published As

Publication number Publication date
EP2069379A2 (en) 2009-06-17
IL197823A0 (en) 2009-12-24
CN101535332A (zh) 2009-09-16
WO2008073598A2 (en) 2008-06-19
EP2069379A4 (en) 2011-02-16
JP2010508043A (ja) 2010-03-18
BRPI0717882A2 (pt) 2013-10-29
CA2667502A1 (en) 2008-06-19
US20080138898A1 (en) 2008-06-12
WO2008073598A3 (en) 2008-12-04
AU2007333485A1 (en) 2008-06-19

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Legal Events

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