MX2009003480A - Metodos para mejorar la produccion de anticuerpo. - Google Patents

Metodos para mejorar la produccion de anticuerpo.

Info

Publication number
MX2009003480A
MX2009003480A MX2009003480A MX2009003480A MX2009003480A MX 2009003480 A MX2009003480 A MX 2009003480A MX 2009003480 A MX2009003480 A MX 2009003480A MX 2009003480 A MX2009003480 A MX 2009003480A MX 2009003480 A MX2009003480 A MX 2009003480A
Authority
MX
Mexico
Prior art keywords
antibody
methods
parent antibody
antibody production
fragments
Prior art date
Application number
MX2009003480A
Other languages
English (en)
Inventor
Daniel Tavares
Xiao-Mai Zhou
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of MX2009003480A publication Critical patent/MX2009003480A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2884—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención comprende la elaboración de variantes de anticuerpo, tal como la variante de huC242, o fragmentos del mismo, en donde las variantes son elaboradas por medio de sustitución de uno o más residuos de aminoácido en un anticuerpo padre. Dicha(s) sustitución(es) se efectúa(n) de manera preferible en una secuencia de estructura de marco de región variable del anticuerpo padre que comprende una cadena pesad y una ligera. Como una consecuencia de dicha(s) sustitución(es), los anticuerpos variantes o fragmentos de los mismos muestran síntesis de anticuerpo mejorada cuando son introducidos en una célula huésped en comparación con el anticuerpo padre.
MX2009003480A 2006-10-31 2007-10-30 Metodos para mejorar la produccion de anticuerpo. MX2009003480A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85536106P 2006-10-31 2006-10-31
PCT/US2007/082994 WO2008073598A2 (en) 2006-10-31 2007-10-30 Methods for improving antibody production

Publications (1)

Publication Number Publication Date
MX2009003480A true MX2009003480A (es) 2009-04-15

Family

ID=39512365

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009003480A MX2009003480A (es) 2006-10-31 2007-10-30 Metodos para mejorar la produccion de anticuerpo.

Country Status (10)

Country Link
US (1) US20080138898A1 (es)
EP (1) EP2069379A4 (es)
JP (1) JP2010508043A (es)
CN (1) CN101535332A (es)
AU (1) AU2007333485A1 (es)
BR (1) BRPI0717882A2 (es)
CA (1) CA2667502A1 (es)
IL (1) IL197823A0 (es)
MX (1) MX2009003480A (es)
WO (1) WO2008073598A2 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2406386T3 (en) * 2009-03-10 2019-04-23 Dsm Ip Assets Bv PROCEDURE FOR IMPROVING THE YIELD OF A POLYPEPTIME
JP5789949B2 (ja) * 2010-10-05 2015-10-07 東ソー株式会社 改良されたｒｎａポリメラーゼ変異体
WO2012065161A2 (en) * 2010-11-12 2012-05-18 Scott & White Healthcare Antibodies to tumor endothelial marker 8
DK2686020T3 (en) 2011-03-17 2017-05-01 Univ Birmingham REDIRECTED IMMUNTERY
CN104487453B (zh) * 2012-06-15 2018-09-28 辉瑞公司 经改良的抗gdf-8的拮抗剂抗体及其用途
PT2766048E (pt) 2012-10-12 2015-02-25 Spirogen Sarl Pirrolobenzodiazepinas e conjugados das mesmas
CN105209077B (zh) 2013-03-13 2019-06-11 麦迪穆有限责任公司 吡咯并苯并二氮杂卓以及其结合物
WO2016037644A1 (en) 2014-09-10 2016-03-17 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
CN109862919A (zh) 2016-10-11 2019-06-07 免疫医疗有限公司 抗体-药物缀合物联合免疫介导的治疗剂
SG11202010469QA (en) 2018-05-23 2020-11-27 Adc Therapeutics Sa Molecular adjuvant
EP3897851A2 (en) 2018-12-17 2021-10-27 Revitope Limited Twin immune cell engager
WO2022150740A1 (en) * 2021-01-11 2022-07-14 Board Of Regents, The University Of Texas System Cross-reactive antibodies recognizing the coronavirus spike s2 domain
GB202102396D0 (en) 2021-02-19 2021-04-07 Adc Therapeutics Sa Molecular adjuvant

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
NZ537610A (en) * 2002-07-02 2006-07-28 Smithkline Beecham Corp Stable formulations of the C242 antibody
AU2004205684A1 (en) * 2003-01-23 2004-08-05 Genentech, Inc. Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture

Also Published As

Publication number Publication date
IL197823A0 (en) 2009-12-24
WO2008073598A2 (en) 2008-06-19
JP2010508043A (ja) 2010-03-18
US20080138898A1 (en) 2008-06-12
EP2069379A4 (en) 2011-02-16
CN101535332A (zh) 2009-09-16
EP2069379A2 (en) 2009-06-17
CA2667502A1 (en) 2008-06-19
BRPI0717882A2 (pt) 2013-10-29
WO2008073598A3 (en) 2008-12-04
AU2007333485A1 (en) 2008-06-19

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Legal Events

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