ES2690386T3 - Composición para escindir un ADN diana que comprende un ARN guía específico para el ADN diana y el ácido nucleico que codifica la proteína Cas o la propia proteína Cas, y sus usos - Google Patents

Composición para escindir un ADN diana que comprende un ARN guía específico para el ADN diana y el ácido nucleico que codifica la proteína Cas o la propia proteína Cas, y sus usos Download PDF

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Publication number
ES2690386T3
ES2690386T3 ES13849670T ES13849670T ES2690386T3 ES 2690386 T3 ES2690386 T3 ES 2690386T3 ES 13849670 T ES13849670 T ES 13849670T ES 13849670 T ES13849670 T ES 13849670T ES 2690386 T3 ES2690386 T3 ES 2690386T3
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target dna
cas protein
nucleic acid
crispr
acid encoding
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Jin-Soo Kim
Seung Woo Cho
Sojung Kim
Jong Min Kim
Seokjoong KIM
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Toolgen Inc
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Toolgen Inc
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Abstract

Sistema de repeticiones palindrómicas cortas interespaciadas agrupadas regularmente tipo II (CRISPR)/proteína asociada CRISPR 9 (Cas9) para introducir roturas bicatenarias en una secuencia de ADN diana en una célula de mamífero, en la que el sistema CRISPR/Cas9 de tipo II comprende: a. una proteína Cas9 con una señal de localización nuclear (NLS), en la que el NLS está en el extremo C, o un ácido nucleico que codifica la proteína Cas9; y b. un ARN guía monocatenario que comprende una porción de ARN CRISPR (ARNcr) fusionada a una porción ARNcr trans-activadora (ARNtracr).
ES13849670T 2012-10-23 2013-10-23 Composición para escindir un ADN diana que comprende un ARN guía específico para el ADN diana y el ácido nucleico que codifica la proteína Cas o la propia proteína Cas, y sus usos Active ES2690386T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261717324P 2012-10-23 2012-10-23
US201361803599P 2013-03-20 2013-03-20
US201361837481P 2013-06-20 2013-06-20
PCT/KR2013/009488 WO2014065596A1 (en) 2012-10-23 2013-10-23 Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof

Publications (1)

Publication Number Publication Date
ES2690386T3 true ES2690386T3 (es) 2018-11-20

Family

ID=50544909

Family Applications (3)

Application Number Title Priority Date Filing Date
ES17206792T Active ES2886448T3 (es) 2012-10-23 2013-10-23 Composición para escindir un ADN diana que comprende un ARN guía específico para el ADN diana y el ácido nucleico que codifica la proteína CAS o proteína CAS, y uso de los mismos
ES13849670T Active ES2690386T3 (es) 2012-10-23 2013-10-23 Composición para escindir un ADN diana que comprende un ARN guía específico para el ADN diana y el ácido nucleico que codifica la proteína Cas o la propia proteína Cas, y sus usos
ES20164644T Active ES2926021T3 (es) 2012-10-23 2013-10-23 Composición para escindir un ADN objetivo que comprende un ARN guía específico para el ADN objetivo y ácido nucleico codificador de proteína Cas o proteína Cas, y uso de la misma

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES17206792T Active ES2886448T3 (es) 2012-10-23 2013-10-23 Composición para escindir un ADN diana que comprende un ARN guía específico para el ADN diana y el ácido nucleico que codifica la proteína CAS o proteína CAS, y uso de los mismos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES20164644T Active ES2926021T3 (es) 2012-10-23 2013-10-23 Composición para escindir un ADN objetivo que comprende un ARN guía específico para el ADN objetivo y ácido nucleico codificador de proteína Cas o proteína Cas, y uso de la misma

Country Status (16)

Country Link
US (9) US20150284727A1 (es)
EP (7) EP4180526A3 (es)
JP (7) JP6517143B2 (es)
KR (5) KR101706085B1 (es)
CN (9) CN116064533A (es)
AU (5) AU2013335451B2 (es)
BR (1) BR112015008708A2 (es)
CA (2) CA2888190C (es)
DE (2) DE202013012597U1 (es)
DK (1) DK2912175T3 (es)
ES (3) ES2886448T3 (es)
HK (4) HK1212732A1 (es)
PL (1) PL2912175T3 (es)
PT (1) PT2912175T (es)
SG (3) SG10201809564YA (es)
WO (1) WO2014065596A1 (es)

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