JP2912618B2 - 組換えｄｎａ生産物及び製造法 - Google Patents

組換えｄｎａ生産物及び製造法

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JP2912618B2
JP2912618B2 JP62073970A JP7397087A JP2912618B2 JP 2912618 B2 JP2912618 B2 JP 2912618B2 JP 62073970 A JP62073970 A JP 62073970A JP 7397087 A JP7397087 A JP 7397087A JP 2912618 B2 JP2912618 B2 JP 2912618B2
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antibody
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cdrs
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ポール ウインター グレゴリー
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MEDEIKARU RISAACHI KAUNSURU
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)

Description

【発明の詳細な説明】 要約 組換DNA技術を用いてイムノグロブリン可変領域の相
補性決定域を異なる特異性を持つたイムノグロブリン
（IG）に由来する可変領域で置き換えることによつて改
変抗体を製造した。改変抗体を製造するための遺伝子コ
ード配列は、長鎖オリゴヌクレオチドを用いた特定部位
の突然変異誘発によつて製造されることもある。 組換えDNA産物及び方法 本発明は、抗体の軽鎖または重鎖の可変領域における
相補性決定領域（CDRs）の少なくとも一部が、異なる特
異性を持つた抗体のCDRsの相似部分と置き換わつた改変
抗体に関与するものである。本発明はまた、その様な改
変抗体の製造法に関与するものである。 通常の抗体または免疫グロブリンは、ジスルフイド結
合で結びついた２本の重鎖と２本の軽鎖から成つてお
り、軽鎖の一方はＨ鎖とジスルフイド結合で結合してい
る。IgGクラスの抗体（すなわちガンマ（Ｇ）クラスの
免疫グロブリン（Ig））の一般的な構造を同時に提出し
た図１に図式的に示してある。 各重鎖は一方の端に１つの可変領域を持ちそれに続い
ていくつかの定常領域がある。各軽鎖は一方の端に可変
領域を、また別の端に定常領域を各各１つずつ持ち、可
変領域は軽鎖の可変領域と並び、定常領域は重鎖の最初
の定常領域と並んでいる。重鎖及び軽鎖の定常領域は抗
原への抗体の結合に直接には関与しない。 重鎖と軽鎖の可変領域の各対が抗原結合部位を形成す
る。軽鎖及び重鎖上のそれらの領域の一般構造は同じ
で、各領域はその配列が比較的保持されている４つの骨
格部から成り、３つの高可変部または相補性決定部（CD
Rs）により連結されている（参照Kabat,E.A.,Wu,T.T.,B
ilofsky,H.,Reid−Hiller,M.and Perry,H.,in"Sequence
s of Proteins of immunological Interest",US Dept.H
ealth and Human Services1983）。 ４つの骨格部は主としてβ−シートコンフオメーシヨン
を採つており、CDRsはループ結合を形成し、時にβ−シ
ート構造の一部を形成している場合もある。CDRsは骨格
部にきわめて接近した位置にあり、他の領域のCDRsと共
に抗原結合部位の形成に寄与している。 可変領域の構造をさらに詳細に説明した参考文献を挙
げる:Poljak,R.J.,Amzel,L.M.,Avey,H.P.,Chen,B.L.,Ph
izackerly,R.P.and Saul,F.,P,PNAS USA,70,3305−331
0,1973;Segal,D.M.,Padlan,E.A.,Cohen,G.H,Rudikoff,
S.,Potter,M.and Davies,D.R.,PNAS USA,71,4298−430
2,1974;Marquart,M.,Deisenhofer,J.,Huber,R.and Pal
m,W.,J.Mol.Biol.,141,369−391,1980。 近年、組換えDNA技術に基づいた分子生物学が進歩
し、目的物の生産のコードとなる異種DNA配列を持つ宿
主細胞の形質転移により広範囲なポリペプタイドが生産
できるようになつた。 EP−Ａ−０ 088 994（シエーリング社）は、予め決
められたリガンドに特異的な免疫グロプリンの軽鎖また
は重鎖の可変領域のコードとなるdsDNA配列から成る組
換えDNAベクターの構造を提唱するものである。そのdsD
NA配列は５′−及び３′−末端に各々開始コドン及び終
了コドンを備えているが、可変領域に不必要なアミノ酸
のコードとなるヌクレオチドはない。このdsDNA配列は
バクテリア細胞を転移するのに用いる。この申請は可変
領域の配列の変化を企図しようとするものではない。 EP−Ａ−１ 102 634（武田薬品工業）は、ヒトIgE
のＨ鎖ポリペプタイドの全部または一部のコードとなる
遺伝子を持つた宿主細菌のクローニングと発現について
述べているがポリペプタイドの配列を変化させようとす
るものではない。 EP−Ａ−０ 125 023（ジエネンテツク社）は組換え
DNA技術をバクテリア細胞において、通常脊椎動物に見
られる免疫グロブリンと類似した免疫グロブリンを作る
ため、またキメラIgまたはその他の改変Igを作成するた
めにその中で提唱した遺伝子改変技術を利用するために
用いることを提唱している。 ‘キメラ抗体’とは、ペプタイド結合によりほかのタ
ンパクの少なくとも一部に付いた免疫グロブリン分子
（Ig）の少なくとも抗原結合部位を含むタンパクを言
う。 上記のジエネンテツク社の申請において延べられた提
案は結果として、有意な量のIgポリペプタイド鎖を表わ
すことも、Ig活性を産み出すことも、目的とするキメラ
Igに鎖を分泌及び集合させることも導かなかつた。 モノクロナール抗体の作製は最初にKohlerとMilstein
によつて発表さた（Kohler,G.and Milstein,C.,Nature,
256,495−497、1975）。このモノクローナル抗体につい
ては、診断薬としてばかりでなく（例、‘immunology f
or the 80s,Eds.Voller,A.,Bartlett,A.,and Bidwell,
D.,MTP Press,Lancaster,1981参照）、治療薬としての
（例、Ritz,J.and Schlossman,S.F.,Blood,59,1−11,19
82参照）広範な使用法が発見されてきた。 最近のIg遺伝子DNAをミエローマ細胞へ安定に導入さ
せる技術の出現は（例、Oi,V.T.,Morrison,S.L.,Herzen
berg,L.A.and Berg,P.,PANS USA,80,825−829,1983;Neu
berger,M.S.,EMBO J.,２,1373−1378,1983;Ochi,T.,Haw
ley,R.G,Hawley,T.,Schulman,M.J.,Traunecker,A.,Kohl
er,G.and Hozumi.N.,PNAS USA.80,6351−6355,1983参
照）、新しい性質を持つた組換えIgを構成するためのin
vitroでの突然変異発生及びDNAトランスフエクシヨン
の利用の可能性を開いた。 しかしIg分子の機能はその３次元構造に依存してお
り、それは順次その１次のアミノ酸配列に依存している
ことが知られている。従つてIgのアミノ酸配列の変更は
その活性に影響を及ばすであろう。さらに、Igのコード
となるDNA配列の変更はIgを発現し、分泌しまたは組み
立てるDNA配列を含む細胞の能力に影響を及ぼすかもし
れない。 従つて、組換えDNA技術により機能的に改変された抗
体を産出する可能性については全く不明確である。 しかし本発明の発明者の同僚らは、それによつて、タ
ンパクの両部分が機能的であるキメラ抗体の分泌を可能
にする方法を提案した。国際特許出願No.PCT/GB85/0039
2（Neuberger et ar.and Celltech Limited）に発表さ
れたこの方法は以下から成る： ａ） 少なくともIg分子のＨ鎖またはＬ鎖の可変領域を
コードとする第１の部分及び、少なくとも第２のタンパ
クの一部分をコード化する第２の部分から成るDNA配列
に連結された適切なプロモーターを含む複製可能な発現
ペクターを調製する。 ｂ） 必要であれば、少なくともIg分子の各々の相補的
なＬ鎖またはＨ鎖の可変部位をコード化するDNA配列に
連結された適切なプロモーターを含む複製可能な発現ベ
クターを調製する。 Ｃ） 生きた哺乳類のセルラインを、上述のように調製
されたベクターと形質転換させる。 ｄ） その形質転換されたセルラインを培養してキメラ
抗体を作る。 DNA配列の第２の部分は次のものをコード化する： ｉ） 異なる種、クラスまたはサブクラスのIg分子の
少なくとも一部、たとえばＨ鎖の定常領域 ii） ある酵素の少なくとも活性部分または全体 iii） 既知の結合特異性を持つたタンパク iv） その配列、機能または抗原性は知られていない
が、既知の遺伝子によつて表現されるタンパク ｖ） リシンの様なタンパク毒素 上記のNeubergerの出願は、その抗体において完全な
可変領域がDNA配列の最初の部分によりコードされてい
るキメラ抗体の製法を示すのみである。それは、可変領
域の配列が改変されたキメラ抗体について示すものでは
ない。 本発明は第１局面において、Ｌ鎖またはＨ鎖の可変領
域におけるCDRsの少なくとも一部分が、特異性の異なる
抗体のCDRsの相似部分と置き換えられた改変抗体を与え
るものである。 CDRの構成及び骨格部の構成に関する決定はいくつか
のIgのアミノ酸配列を基準として行われた。しかしそれ
によつていくつかのIgの３次元構造が決定されてきた
が、それによつてIgの抗原結合部位は可変領域のシート
構造に支えられた３つのループ部から成つていることが
わかる。ループ部は一般に相当オーバーラツプする部分
はあるものの正確にはCDRと一致するものではない。 さらに、ループ部のアミノ酸残基の全てが溶媒の到達
が可能ではなく、ある場合において骨格部のアミノ酸残
基が抗原結合に関係しいることがある（Amt,A.G.,mariu
zza,R.A.,Phillips,S.E.V.and Poljak,R.J.,Science,23
3,747−753,1986） ２ヶ所の抗原結合部位の可変部は、鎖間非共有相互作
用により正しい方向に保たれていることも知られてい
る。これらはCDRsのアミノ酸残基に関係するかもしれな
い。 この様に、１つの可変領域の抗原結合容力を他に転移
するためには、全てのCDRsを供与体の可変部の完全なCD
Rsと置き換える必要はなかろう。抗原結合部位からアク
セス可能な残基を転移させることが必要であり、これは
CDR残基のみならず骨格部残基の転移にも関係するもの
と思われる。 また、鎖間相互作用に必要な残基が受容体の可変領域
において確実に保存されることが必要であろう。 ドメイン内では、２つのジスルフイドで結合したβ−
シート（それゆえ、CDRループの両端が）が一緒に包み
込まれていること及びそれらの方向が比較的保持されて
いる。とはいえ、これらのβ−シートの、包み込みと方
向づけにおける僅かなずれは慥かに起る。（Leak,A.M a
nd Cathoia,C.,J.Mol.Biol.,160.,325−342,1982）。し
かし、重鎖および軽鎖の可変ドメインの、一緒の包み込
みと方向性は比較的良く保存されている。（Chathia,
C.,Novotny,J.,Bruccoleri,R.and karplus,M.,J.Mol.Bi
ol186,651−653,1985）新しい抗原を構築する場合には
包み込みと方向性が抗原の結合容量に損害を与える程変
化しないように留意する必要がある。 この様に、単に１つまたはそれ以上のCDRsを相補的な
CDRsと置換することによつて、機能的に改変された抗体
が必ずしもできるわけではないことは明らかである。し
かし、上述の説明が与えられれば、技術的に熟練した人
の能力の範囲内で日常の実験法を実施することによつて
または試行錯誤試験によつて機能的に改変された抗体を
得ることが十分できる。 好ましくは、重鎖と軽鎖の可変域を少くとも部分的な
CDRの置換そして必要ならば、部分的な骨格域置換と配
列を変化させることによつて改変した。CDRは、骨格領
域が由来している抗体と同じクラスにさらに近縁のサブ
クラスからさえ由来することがあるけれども、CDRsが異
るクラスの抗体や、好ましくは異る種の抗体から由来す
ることが考えられる。 かくして、例えば、マウス由来のCDRsをヒト抗体の骨
格領域に接合することもあり得ると考えられる。この取
り合せは、モノクローナル抗体の治療的使用の場合特に
重要であろう。 現在においては、完全なマウス可変領域を含むマウス
モノクローナル抗体をヒトに注射した場合、ヒトの身体
の免疫系がマウスの可変域を異物として認識し、それに
対して免疫応答を生ずる。かくして引き続いてヒト抗体
またはキメラ抗体をヒトに注射した場合は、その効果は
異物に対する身体の免疫系の作用によつて著しく減少す
る。本発明の改変抗体においては、抗体のCDRsのみが身
体にとつて異物である。したがつて人間の治療に使用し
た場合副作用を最小限に止める筈である。例えば、ヒト
とマウスの骨格域は特徴的配列であるが、マウスCDRsか
らヒトのCDRsを区別するなんらの特徴もないようであ
る。したがつてヒト骨格中にマウスCDRsを含む抗体はも
早生粋のヒト抗体同様身体にとつて異物とはならない道
理である。 本発明の改変抗体についてさえも、改変抗体を受けた
人によつて抗イデイオタイプ型の反応があるようであ
る。この反応は、改変抗体の抗体結合部位に向けられ
る。少くともある抗イデイオタイプ型抗体はCDRsと骨格
粋を加橋する部位に向けられると考えられている。それ
故、同じ、部分的または完全なCDR置換を行つているが
一連の異なる骨格域上で行つた一組の抗体を用意するこ
とは可能であろう。このようにして、抗イデイオ型反応
のために、最初の改変抗体が効かなくなつたらば、その
シリーズからの２番目の改変抗体を使い、これを続けて
抗イデイオ型反応効果を克服できるかもしれない。かく
して、改変抗体の有用な命を伸ばす可能性がある。 好ましくは、改変抗体は、天然抗体またはその断片の
構造を持つている。かくして改変抗体は、完全抗体、
（Fab）２断片、Fab断片、軽鎖のダイマー、もしくは重
鎖のダイマーを含むことがある。代替として、改変抗体
は、上に引用したNeubergerの適用において記述されて
いるキメラ抗体であつてもよい。このような改変キメラ
抗体製造は、Neubergerの適用において記された方法と
下記に述べる方法を併用して行うことができる。 本発明は、２番目の面として以下を含むこのような改
変抗体を製造するための方法を含む。 ａ） 少くともIg重鎖、もしくは軽鎖の可変域をコー
ドするDNA配列に操作的に結合させた適切なプロモータ
ーを含む最初の複製可能な発現ベクターを製造する。可
変領域は、最初の複製可能な発現ベクターを製造する。
可変領域は、最初の抗体からの骨格域を含み、CDRsは特
異性が異なる２番目の抗体からのCDRsの少なくとも部分
を含む。 ｂ） 必要があれば、少くとも相補的なIg軽鎖、重鎖
の可変域をコードするDNAに操作的に結合した適切なプ
ロモーターを含む２番目の複製可能な発現ベクターを調
製する。 ｃ） セルラインの第１のまたは両方の調製ベクター
と形質転換させる。 ｄ） 形質転換したセルラインを培養し、改変抗体を
作る。 本発明は次のものも含む、セルラインを形質転換させ
るために用いるベクター、形質転換ベクターの生産に用
いるベクター、形質転換ベクターと形質転換させるセル
ライン、予備のベクターと形質転換させるセルライン、
及びそれらの製法。 形質転換され改変抗体を生産するセルラインは不死の
哺乳類のセルラインで、ミエローマ、ハイブリドーマ、
トリオーマまたはクアドローマセルラインの様なリンパ
由来のものが有利である。セルラインは、Ｂ細胞の様な
正常の類リンパ球から成つていてもよく、それはEpstei
n−Barrウイルスの様なウイルスとの形質転換により不
死化される。最も適した不死化セルラインはミエローマ
セルラインまたはその誘導物である。 改変抗体の生産に用いるセルラインには哺乳類のセル
ラインが適しているが、それに替つて細菌セルラインま
たは酵母セルラインの様なその他の適当なセルラインを
用いてもよい。特にE.Coliから誘導される細菌株が使用
可能であることが予想される。 ミエローマセルラインの様な不死化リンパセルライン
の中には、正常な状態で単離されたIgL鎖またはＨ鎖を
分泌するものがある。その様なセルラインが本案の過程
のａ）において調製されたベクターと形質転換された場
合にはｂ）を行う必要はなくなり、通常分泌される鎖が
ａ）で調製されたベクターによりコード化されるIg鎖の
可変領域と相補的となる。 しかし不死化セルラインが分泌しない場合または相補
的な鎖を分泌しない場合、ｂ）を行う必要がある。この
ステツプｂ）はａ）で作られたベクターをさらに処置を
加えて行いそのベクターが改変抗体のＬ鎖またはＨ鎖の
可変領域のみならず、相補的な可変領域をもコード化す
るようにする。 代替として、第２のベクターを調製し、それを使つて
不死化細胞を形質転換することにより、ステツプｂ）を
行う。この別法により構築物の調製がより容易にできる
ようになるが、抗体の効率的生産に結びつかないことが
あるという点で最初の別法より好ましくない場合があ
る。 それによつてその様なベクターを作ることができ、不
死化セルラインの形質転換に用いることができる技術は
よく知られており、本案のどの部分をも構成するもので
はない。 不死化セルラインが相補的なＬ鎖またはＨ鎖を分泌す
る場合、形質転換セルラインはたとえば適当な細菌細胞
をベクターと形質転換させた後にスフエロプラスト融合
により細菌細胞を不死化セルラインと融合させることに
よつて生産できる。もしくはDNAを電気穿孔法によつて
直接不死化セルラインに導入してもよい。 改変された可変領域をコード化するDNA配列はオリゴ
ヌクレオチド合成により調製できる。これには少なくと
も第１の抗体の骨格部配列と第２の抗体のCDRs配列が知
られているか容易に決定できるかが必要である。これら
の配列の決定、オリゴヌクレオチドからのDNAの合成、
及び適切なベクターの調製はかなり骨の折れる仕事であ
るが、技術的に熟練した人がここに示した方法に照らし
て行えば容易に実行することが可能な既知の技術を必要
とする。 この戦略を繰返して異なる結合部位を導入することが
望ましければ、オリゴヌクレオチドの骨格部分は再使用
できるので単にCDRsをコードするオリゴヌクレオチドの
合成だけ行えばよい。 この技術の便利な変法は、CDRsを缺いていて、４つの
骨格域がその融合部に適当な制限酵素部位を持つて、た
がいの融合している合成遺伝子を造ることを含んでい
る。次に両端に附差端を有する二重銷合成CDRのカセツ
トが骨格領域の接合部位に連結される。この変法を達成
するためのプロトコールが、模式的に添付図中の第６図
に示されている。 もしくは改変された可変領域をコード化するDNA配列
はプライマーに統制されたオリゴヌクレオチドの部位指
向性突然変異誘起により調製できる。この技術は望む変
異をコードするオリゴヌクレオチドを変異されるべき領
域を含むDNAの単鎖とバイブリツドを形成させ、その単
鎖をテンプレートとして用いてオリゴヌクレオチドを伸
長させ変異を含んだストランドを製造することを含む。
この技術は多様な形で以下に述べられている:Zoller,M.
J.and Smith,M.,Nuc.Acids Res.,10,6487−6500,1982;N
orris,K.,Norris F.,Christiansen,L.and Fiil,N.,Nuc.
Acids Res.,11,5103−5112,1983;Zoller,M.J.,and Smit
h,M.,DNA,３,479−488（1984）;Kramer,W.,Schughart,
K.and Fritz,W.−J.,Nuc.Acids Res.,106475−6485,198
2。 様々な理由から、この技術はその最も簡単な形におい
ては必ずしも高頻度で変異は起こさない。M13をベース
としたベクターにおいて単一及び多数の変異を導入させ
る改善技術についてCarterらが述べている（Carter,P.,
Bedouelle H.and Winter,G.,Nuc.Acids Res.,13,4431−
4443,1985）。 長いオリゴヌクレオチドを用いて多くの変異を同時に
導入することの可能性が証明された（Carter et al、同
引用文中に示されている）、従つて各々がCDRをコード
化する単一オリゴヌクレオチドは、第２の抗体の３つの
CDRsを第１の抗体の骨格部に導入するために使うことが
できる。この技術はトータルの遺伝子合成に比べて困難
でないばかりではなく必要とされる特異性を持つた可変
領域を発現するのに特に便利な方法を表わしており、発
現プラスミドへ挿入するためにVH領域全体を適合させる
よりも簡単でありうる。 部位指向性の突然変異誘起に用いられるオリゴヌクレ
オチドは、オリゴヌクレオチド合成によつて調製される
かまたは、適切な制限酵素を用いて第２の抗体の可変領
域をコードとするDNAから単離される。その様な長いオ
リゴヌクレオチドは一般に少なくとも30個の塩基から成
り、80個までまたはそれ以上の長さになるかもしれな
い。 上記の技術は必要であれば、方法のｂ）項のベクター
を作るのにも用いられる。 本発明の方法は、非人間性モノクローナル抗体を“人
間化する”ために特に用いられるものとして見られる。
従つてたとえば、ある特定のヒトガン細胞に対するマウ
スのモノクローナル抗体はよく知られた技術によつて生
産できる。マウスモノクローナル抗体のCDRsは、それか
ら部分的にまたは全体的にヒトモノクローナル抗体の骨
格部に融合され、適当なセルラインにより大量生産され
る。この様にしてできた生産物は、特異的な標的を持ち
本質的にはガン細胞を認識するヒト抗体であるが、反イ
ジオタイプ反応が実際に現われない限りヒト免疫系によ
つて有意な程度認識されないであろう。従つて本案の方
法及び生産物は臨床面に特に使用されるであろう。 本発明について実例のみによつて述べるが参考として
は以下に示す図を添える： 図１はIgG分子の構造を示す模式図。 図２はB I−８抗体のVH領域と比較したNEWMのVH領域
のアミノ酸配列を示す。 図３はHuVMP遺伝子のアミノ酸及びヌクレオチド配列
を示す。 図４はHuVNP−IgEとMoVNP−IgEの結合阻害法における
結果の比較を示す。 図５は部位指向性突然変異誘起による３つのオリゴヌ
クレオチドの構造を示す。 図６は４つが１つに融合した骨核領域を含むベクター
にCDRカセツトを挿入することによつてCDR置換を構築す
るためのプロコートである。 図７は抗体Dl.3の可変領域の配列とそれをコードする
遺伝子を示す。 図８はDl.3可変領域遺伝子のクローニングのためのプ
ロトコールを示す。 例１ 例１ではヒトＨ鎖の骨組構造部分およびマウスＨ鎖由
来のCDRsとからなるＨ鎖の可変ドメインをもつ改変抗体
の産生方法を示す。 骨組構造部分は結晶構造が知られている（Poljak et
al.,loc.,cit,and Reth,M.,Hammerling,G.J.and Rajews
ky,K.,EMBO J.,１,629−634,1982.参照）ヒトのミエロ
ーマＨ鎖（NEWM）から誘導した。 CDRsはハプテンNP−cap（４−ヒドロキシ−３−ニト
ロフエニルアセチル−カプロン酸:KNP-cap＝1.2μＭ）
に結合するマウスのモノクロナール抗体B.1−８（Reth
et al.,loc.cit.参照）から誘導した。 B1−8CDRsおよびNEWM骨組構造からなる可変ドメインH
uVNPをコーデイングしている遺伝子を次に示す遺伝子合
成によつて作製した。 NEWMのＶHドメインのアミノ酸配列をB1−８抗体のVH
ドメインのアミノ酸配列と比較して図に示す。配列は骨
組構造部分とKabatら（loc,cit.）によるCDRsに分割さ
れる。保存された残基は線で示した。 HuVNPのアミノ酸およびヌクレオチド配列は、図３に
示すようにNEWM抗体の骨組構造部分とB1−８抗体からの
CDRsとが交互になる。HuVNP遺伝子は、ベクターpSV−Ｖ
NP（Neuberger,M.S.,Williams,G.T.,Mitchell,E.B.,Jou
hal,S.,Flanagan,J.G.and Rabbitts,T.H.,Nature,314,2
68−270,1985参照）におけるMoVNP遺伝子の切断を、HuV
NPドメインをコーデイングする合成断片に取り替えるこ
とによつて誘導した。このように、５′側及び３′側の
ノンコード配列、リーダー配列、Ｌ−Ｖイントロン、５
個のＮ末端および４個のＣ末端がMoVNP遺伝子から誘導
され、残りのコーテイングする配列は合成HuVNP断片か
ら誘導される。 HuVNP断片を組合せたオリゴヌクレオチドはHuVNP遺伝
子の対応する部分以下で配列される。クローニングの都
合のため、オリゴヌクレオチド25と26bの端が、Hind II
I部位に続いたHind II部位を形成しているので、25/26b
オリゴヌクレオチドの配列はHuVNP遺伝子と異なる。 HuVNP合成断片はPst I−Hind III断片として組立て
た。ヌクレオチド配列は、マウス定常ドメイン遺伝子の
配列から取つた最適コドン用法で、コンピユータープロ
グラムANALYSE Q（staden,R.,Nuc.Acids.Res.,12,521−
538,1984）を用いるタンパク質配列から誘導した。オリ
ゴヌクレオチド（全部で１〜26b、28）は、14〜59の残
基でサイスが変化し、Biosearch SAMまたはApplied Bio
systems machine上に作製され、8M−尿素ポリアクリル
アミドゲル（Sanger,F.and Coulson,A.,FEBS Lett.,87,
107−110,1978参照）上で精製された。 本オリゴヌクレオチドは、オリゴヌクレオチドを含有
する８個の単独でストランドしたブロツク（Ａ−Ｄ）、
すなわち、［1,3,5,7］（ブロツクＡ）、［2,4,6,8］
（ブロツクＡ′）、［9,11,13a,13b］（ブロツクＢ）、
［10a,10b,12/14］（ブロツクＢ′）、［15,17］（ブロ
ツクＣ）、［16,18］（ブロツクＣ′）、［19,21,23,2
5］（ブロツクＤ）および［20,22/24,26a,26b］（ブロ
ツクＤ′）を組合せたものである。 典型的な組合せられたオリゴヌクレオチドの例とし
て、ブロツクＡをあげると、50p moleのオリゴヌクレオ
チド1,3,5および７が、T4ポリヌクレオチドキナーゼと
５′の端でリン酸エステル結合されて、５μCi［γ−32
P］ATP（Amersham3000Ci/m mole）とリン酸エステル結
合された5p moleの末端オリゴヌクレオチド［１］と混
合された。これらのオリゴヌクレオチドは、150μの5
0mM Tris.C1,pH7.5,10mH MgCl2緩衝液中で、スプリント
としての非分解性オリゴヌクレオチドとともに80℃に加
熱し、室温で30分以上冷却して焼きなまされた。リゲー
シヨンのために、ATP（1mM）およびDTT（10mM）に50U
T4DNAリカーゼ（Anglian Biotechnology Ltd.）を加
え、30分間インキユベートした。EDTAを10mM加え、試料
をフエノールで抽出し、エタノールから沈殿させ、20μ
の水で溶解させ、等容量のフオルムアミド色素ととも
に１分間沸騰させた。試料を0.3mm8M−尿素10％ポリア
クリルアミドゲルにかけた。期待されたサイズのバンド
をオートラジオグラフ法で検出し、ソーキングで溶出さ
せた。 スプリントオリゴヌクレオチドを用いて、ブロツクＡ
からＤ、およびブロツクＡ′からＤ′のそれぞれ全体か
らなる２個の単独ストランドを組立てた。こうして、ブ
ロツクＡ−Ｄは100p moleのオリゴヌクレオチド10a,16
と20をスプリントとして用いて前パラグラフで設定した
ように、30μ中で焼きなまし、リゲートした。ブロツ
クＡ′−Ｄ′はオリゴヌクレオチド7,13bと17をスプリ
ントとして用いて、リゲートした。 フエノール／エーテル抽出後、ブロツクＡ−Ｄはブロ
ツクＡ′−Ｄ′とともに焼きなまし、少量をベクターM1
3mp18（Yanish−Perron,C.,Vieira,J.and Messing,J.,G
ene,33,103−119,1985）でクローンし、Pst IおよびHin
d IIIで切断し、ジデオキシ技法（Sanger,F.,Nicklen,
S.and Coulson,A.R.,PNAS USA,74,5463−5467,1979）に
よつて遺伝子を配列した。 MoVNP遺伝子はHind III−BamH I断片としてベクター
（pSV−VNP（Neuberger et al.,loc.cit.）からベクタ
ーM13mp8（Messing,j.and Vielra,J.,Gene,19,269−27
6,1982）へ転位した。合成HuVNP断片によるMoVNPコーデ
イング配列の取り替えを促進するために、３個のHind I
I部位は、部位指向性変異原発生によつて、５′をコー
デイングしない配列から除去された。続いて新しいHind
II部位を第４番目の骨組構造部分（図２におけるFR4）
末端付近に導入した。ベクターをPst IおよびHind IIで
切断することによつて、大部分のVNP断片がPst I−Hind
II断片として挿入された。Hind II部位における配列は
部位指向性変異原発生によつてNEWM FR4に訂正された。
HuVNP遺伝子を運搬するHind III−BamH I断片をM13から
運かし、pSV−VNPへクロークバツクして、MoVNPを取り
替え、ベクターpSV−HuVNPを産生する。最後に、ヒトIg
E（Flanagan,J.G.and Rabbitts,T.H.,EMB J.,１,655−6
60,1982）のＨ鎖定常ドメインのための遺伝子がBamH I
断片として導入され、ベクターpSV−HuVNP.HE.を与え
る。これはスフエロプラスト融合によつてミエローマ・
ラインJ558Lヘトランスフエクトされた。 pSV−HuVNP.EHにおけるHuVNP遺伝子の配列はHind III
−BamH I断片をM13mp8（Messing et al.,loc.cit.）へ
再クローンすることによつて点検した。J558Lミエロー
マ細胞はLambda1L鎖を分泌するが、Lambda1L鎖はMoVNP
可変ドメインを含有するＨ鎖と連関して、NP−Capまた
はその関連ハプテンNIP−Cap（３−ヨード−４−ヒドロ
キシ−５−ニトロフエニルアセチル−カプロン酸）（Re
th,M.,Hammerling,G.J.and rajewsky,K.,Eur.J.Immuno
l.,８,393−400,1978）のための結合部位を作製する。 プラスミドpSV−HuVNP.HEはgptマーカーを含有するの
で、安定にトランスフエクトされたミエローマがミコフ
エノール酸を含有する培地中で選択された。 トランスフエクタントはHuVNP可変ドメイン（すなわ
ち、”ヒト化”マウス可変部分）およびヒトγ定常ドメ
イン、およびJ558Lミエローマ細胞からのlambda1L鎖か
らなるＨ鎖を有する抗体（HuVNP−IgE）を分泌する。 いくつかのgpt+クローンの培養液上清はラジオイムノ
アツセイで定量して、抗体に結合するNIP−capを含有す
ることが発見された。このようなクローンによつて分泌
された抗体はアフイニテイークロマトグラフ法によつ
て、NIP−capセフアローズ（セフアローズは登録商標）
上に培養液上清から精製された。ポリアクリルアミド−
SDSゲルは、タンパク質がキメル抗体MoVNP−IgE（Neube
rger et al.,loc.cit.）を区別できないことを示唆し
た。 HuVNP−IgE抗体は、抗ヒトIgEおよびウシ血清アルブ
ミンと結合したNIP−capの両者との結合に関してMoVNP
−IgEと効果的に競合する 種々の濃度のHuVNP−IgEおよびMoVNP−IgEは、以下の
（ａ）〜（ｅ）に示すもので被覆したポリビニル微量適
定プレートへの放射性標識化MoVNP−IgEの結合を競合す
るために用いられた。（ａ）ヒツジ抗ヒトIgE抗原（Sew
ard Laboratories）；（ｂ）NIP−cap−ウシ血清アルブ
ミン；（ｃ）Ac38抗イデイオタイプ抗体；（ｄ）Ac146
抗イデイオタイプ抗体；および（ｅ）ウサギ抗MoVNP抗
血清。結合率は、MoVNP−IgM抗体（Neberger,M.S.,Will
iams,GT.and Fox,R.O,Nature,,312,604−608,1984）ま
たはVHCDR2部分に主として位置する13残基でMoVNP−IgM
抗体と異なるIgM抗体であるJW5/1/2の存在においても測
定された。 結合率測定の結果を図４に示すが、黒まるがHuVNP、
白まるがMoVNP、黒四角がMoVNP−IgM、そして、白四角
がJW5/1/2を表わす。 結合率は阻害剤のない場合の結合と相対的に表わし
た。 NP−capおよびNIP−capへのHuVNP−IgEのアフイニテ
イーは励起光に295nmを使用して340nmのけい光を測定
し、MoVNP−IgEへのHuVNP−IgEのアフイニテイーと比較
した（Eisen,H.N.,Methods Med.Res.,10,115−121,196
4）。 抗体溶液はリン酸緩衝生理食塩液で100mlに希釈し
て、孔径0.45μｍの酢酸セルロース製メンブランフイル
ターでろ過し、NP−capで0.2〜20μＭの範囲で適定し
た。対照として、ハプテンに結合しないマウスDI−３抗
体（Mariuzza,R.A.,Jankovic,D.L.,Bulot,G.,Amit,A.
G.,Saludjian,P.,le Guern,A.,Mazie,J.C.and Poljak,
R.J.,J.Mol。Biol.,170,1055−1058,1983）が並列して
適定された。 DI−３抗体のけい光強度に対するHuVNP−IgEのけい光
強度の比の減少は、抗原結合部位におけるNP−capの占
有率に比例した。最大消失は両抗体について約40％であ
り、ハプテンの解離定数は３回くり返しデータを最小二
乗法で双曲線へ適合させて決定した。 NIP−capについては、ハプテン濃度を10〜300nMに変
化させて、約50％のけい光の消失が飽和状態で観察され
た。抗体の濃度は解離定数の値に匹敵するので、データ
は最小二乗法によつて、きびしい結合阻害を表わす式
（segal,I.H.,in"Enzyme Kinetics",73−74,wiley,New
York,1975）に適合させた。 これらの抗体についてのデータから得た結合定数を以
下の表１に示す。 表１ KNP−cap KNP−cap MoVNP−IgE 1.2μＭ 0.02μＭ HuVNP−IgE 1.9μＭ 0.07μＭ これらの結果は、抗体のアフイニテイーはほぼ同じで
あり、またアフイニテイーの変化は酵素の活性部位にお
ける水素結合またはフアンデルワールス接触点の損失か
ら期待されてよりも少なかつた。 こうして、抗原結合能力を有意に損失することなく、
ヒト骨組構造部分をもつ可変ドメインおよびマウスCDRs
とからなる、人工の小ハプテンに特異的な抗原を産生す
ることが可能であることを示した。 図４（ｂ）に示すように、HuVNP−IgE抗体は抗体Ac14
6によつて認識されたMoVNPイデイオタイプ決定因子を失
つた。さらに、HuVNP−IgEはAc38抗体とあまりよく結合
せず（図４（ｃ））、HuVNP−IgEはポリクロナール・ウ
サギ抗イデイオタイプ抗血清（図４（ｅ））によつて認
識された多くの決定因子を失つた。 HuVNP−IgE抗体は実質的にマウスCDRsのすべての抗原
結合能力を獲得したけれども、マウス抗体の抗原性はほ
とんど獲得していないということがわかつた。 図４（ｄ）と（ｅ）の結果はさらに実際的なことを暗
示している。マウス（またはヒト）CDRsは、１組のヒト
骨組構造（抗体１）から別の１組のヒト骨組構造（抗体
２）へと転移させられることができた。治療において
は、抗体１への応答において発生した抗イデイオタイプ
抗体は抗体２に弱く結合する方がよい。こうして、抗イ
デイオタイプ応答は中和を開始し、抗体１処理は、抗体
２、および何度と用いられた望ましい特異性をもつCDRs
に続行されされた。 例えば、CDRsをコードするオリゴヌクレオチドは、骨
組領域をコードする一組のオリゴヌクレオチドと共に再
び用いることができる。 上の仕事は、抗原の結合特性は、もとの抗体が小さな
ハプテンに特異的である限り、１つの骨組から別の骨組
に活性を失なうことなく移行することができるというこ
とを示した。 一般的に小さなハプテンは抗原の結合部位の裂目に適
合することが知られている。しかし、これは天然の抗原
にはあてはまらないことがある。たとえば、タンパクま
たはポリサツカライド上のエピトープ部位を含む抗原が
そうである。このような抗原については、抗体は裂目に
缺けており、（浅いくぼみを持つているだけかも知れな
い。）表面のアミノ酸残基は抗原結合において重要な役
割を演じているかも知れない。それゆえ、人工的な抗原
に関する仕事が、CDR置換が天然抗原の結合についての
性質を移行させるために拡大適用できるかもしれないと
いうことを結論できる程はつきり示しているとはにわか
に断じ難い。 それ故、CDR取り替えがこの目的に用い得るかどうか
の確認の仕事を実行した。この仕事は、HuVNP遺伝子類
似の可変ドメインを産生するためのマウスCDRsおよび骨
組構造部分の側面についての３個の合成オリゴヌクレオ
チドのコーデイングを用いてプライマー指向およびオリ
ゴヌクレオチド指向性変異原発生を用いることにも関与
した。 例２ lysuzymeとantilysozyme抗体（Amitら、loc.cit.）の
複合体の３次元構造はＸ線結晶解析によつて解明され
た。抗体と抗原の間の相互作用を有する大きな表面が存
在している。抗体は２本のマウスIgG Iクラス（Ｈ）の
重鎖と２本のkappの軽鎖（Ｋ）を持つており、ＦにH2K2
と表示してある。重鎖可変域のDMA配列はDl.3ハイブリ
ドーマのmRNAからcDNAを作ることにより決定し、プラス
ミドとM13ベクターにクローニングした。その配列は図
７に示してあり、その中においてボツクスで囲つた残基
は３つのCDRsを含み星はlysuzymeと接触する残基につけ
てある。３個の合成オリゴヌクレオチドがHuVNP遺伝子
のＶHCDRsに代るDl.3 VHCDRsの導入するために立案し
た。HuNP遺伝子を上記で述べたようにBamH I−Hind III
としてのM13mp8クローンした。各オリゴヌクレオチドは
５′末端で12個のヌクレオチドおよび３′末端で12個の
ヌクレオチドをもち、適当なHuVNP骨組構造を捕足す
る。各オリゴヌクレオチドの中心部分は、図５に示した
ように、Dl.3抗体のCDR1,CDR2、またはCDR3をゴードす
る。そしてそのためのレフアレンスを作製した。本図か
らわかるように、これらのオリゴヌクレオチドは、それ
ぞれ、39,72および48のヌクレオチドの長さである。 10p moleのDl.3 CDR1プライマーは５′末端でリン酸
エステル結合され、M13−HuVNP鋳型のラグにアニールさ
れ、T4DNAリガーゼの存在下でDNAポリメラーゼのKlenow
断片とともに延長された。15℃におけるオリゴヌクレオ
チドの延長後、サンプルを用いてE.Coli菌株BHM71/18mu
tLをトランスフエクトしプラークをグリツドし、感染コ
ロニーとして生長させた。 ニトロセルローズフイルター上に移した後、５′末端
をラベルした10pモールのDl.3CDR Iプライマーと30μCi
32−Ｐ−と30μCi32−Ｐ−ATPを用いて室温でプローブ
した。60℃で３秒あらつた後、オートラジオグラフイー
にかけたところコロニーの約20％がプローブとよくハイ
ブリツド形成していた。これらの技術は、すべて、P.Ca
rter,H,Bedouelle,M.M.Y.Waye及びG.Winter（1985）に
よつて書かれ、Anglian,Biotechnology Limited,Hawkin
s Road,Colchester,EssexCO2 8JXによつて出版された"
M13におけるオリゴヌクレオチドの特定部位の突然変異
誘発”と題する実験マニユアルに完全に記述されてい
る。いくつかのクローンの配列を決定しHUVNPCDR IのD.
13CDR Iによる置換を確認した。このMl3テンプレートを
M1.3CDR2プライマーを用いた第２ラウンドの変異誘発に
使用した。最後にCDRsの１と２の両方で置換されたテン
プレートを題３ラウンドの変異誘発にD.13CDR3プライマ
ーとともに使用した。この場合には３ラウンズの突然変
異誘発を用いた。 Dl.3CDRsを含む可変領域を次に重鎖Hu＊をコードする
ベクターを産出するようにヒトIgG2の重鎖コンスタント
領域をコードする配列につなげた。上述のようにそのベ
クターでT558L細胞をトランスフエクトした。抗体HU＊ 2
L2が分泌された。 比較の目的のために、Dl.3抗体に対する可変域の遺伝
子を適当なベクターに挿入し、マウスIgGlのコンスタン
ト領域をコードする遺伝子につなぎＨと同じ配列を持つ
た重鎖Ｈをコードする遺伝子を産出した。これを成し遂
げるためのプロトコールを図８に示してある。 図８に示すように、Dl.3重鎖ＶとCHl領域と蝶つがい
領域の一部をコードする遺伝子をM13mp9ベクターにクロ
ーニングした。 次にベクター（ベクターＡ）をNco Iで切り、Klenow
polymeraseでブラントに揃えPst Iで切つた。Pst I−Nc
o I断片を精製しPst I−Hind IIで切つたMVNPベクター
にクローニングしてMVNPコード配列の大部分を置換し
た。MVNPベクターはマウス可変域の遺伝子を含んでおり
プロモーター、５′−リーダー、５′及び３′のイント
ロンがM13mp9にクローニングされてできたものである。
この産物は、ベクターＢとして図８に示してある。 ２ケのプライマーの存在で、ベクターＢの単鎖テンプ
レートに基いて、特定部位の突然変異誘発を用いて、CH
l領域のＮ末端拭とＶ−領域のＮ末端に近いPst Iをコー
ドする配列を除去する。かくして、Dl.3のＶ領域はVNP
のそれを置換し図８のベクターＣを産生する。 ベクターＣを次にHind IIIとBamH Iそしてそのとき生
成した断片をHind III/BanH Iで切つたM13mp9に挿入し
た。産物をHind IIIとSac Iで切り、断片を、VNP可変域
をDl.3可変域で置換するように、Hind III/Sac Iで切断
したPSV−VNPに挿入した。マウスのIgGlコンスタント領
域をベクター中にSac I断片としてクローニングし図８
のベクターＤを産生する。 図８のベクターＤをJ558Lに細胞にトランスフエクト
すると、重鎖Ｈ＊がlambda軽鎖Ｌと結びついて抗体Ｈ＊
2L2として分泌される。 分離されたＫまたはＬ軽鎖は適当な抗体（例えばDl.3
を用いＫ軽鎖を産生する。）を塩酸グアニジン中２−メ
ルカプトエタノールで処理し、遊離内部鎖スルフヒドリ
ル基をヨードアセトアミドでブロツクし、解離した重鎖
と軽鎖の塩酸グアニジン中HPLCによつて分離することに
よつて得ることができる。 分離した重鎖と軽鎖を混合し、非変性バツフアー中に
透析し、再会合とリフオールデイングを促進することに
より、異なる重鎖と軽鎖を会合させ、機能を有する抗体
を産生することができる。然るべく再会合され、折りた
たまれた抗体分子はプロテインＡ−セフアロースカラム
上で精製することができる。上の操作の適切な組み合せ
を用いることにより、次の抗体が調製された。 H2K2 （Dl ３抗体） Ｈ＊ 2L2（Dl.3重鎖、lambda軽鎖） Ｈ＊ 2K2（Dl.3の組換へによる合成物） HU＊ 2L2（“ヒユーマナイズド"Dl.3重鎖、lambda軽鎖） HU＊ 2K2（“ヒユーマナイズド"Dl.3） lambda軽鎖を含む抗体の抗原と結合する容量については
試験しなかつた。その他の抗体は試験したので結果を表
２に示してある。 表２ 抗体 lysozyle（nM）に 対する解離恒数 Dl.3（H2K2） 14.4 Dl.3（H2K2） 15.9,11.4 （再会合） リコンビナントDl.3 9.2 （Ｈ＊ 2K2）（再会合） “ヒユーマナイズド” 3.5,3.7 Dl.3（HU2L2） （再会合） lysozymeに対する対向の親和性を、290nmで励起さ
せ、340nmの放射を観測して蛍光クエンチング法により
測定した。抗体溶液は、燐酸で緩衝した食塩溶媒中で15
−30μg/mgまで稀釈し、濾過（0.45nm−セルローズ）卵
白lysozymeで測定した。抗体にlysozymeを加えると、蛍
光のクエンチングが起り（＞100％のクエンチ）そして
データを最小二乗法で強い結合による阻害を表す方程式
に適合させた。（I.H.Segal in Enzyme Kinelics,P73−
74、Wiley,New York1975）。一見して、データはlysozy
meに対する“ヒユーマナイズド”抗体の結合はもとのD
l.3抗体の場合よりも強いように思われるけれども、こ
れは今後確認する必要がある。しかし、ヒユーマナイズ
ド抗体はlysozymeとDl.3と同等の親和性でlysozymeと結
合するということは明白である。さらに研究を進めたと
ころ、（外の抗体−CAMPATHI）すべての３つのプライマ
ーで上のようにプライムすることにより、CDRs1,2及び
３を同時に交換することができることがわかつた。10％
のハイブリツド陽性体がCDR Iプライマーによるスクリ
ーニングで検出された。これらのうち30％は、すべての
CDRsが置換されたトリツプル変異体を含んでいた。 したがつて、CDR置換は人工抗原（ハプテン類）に対
してのみならず天然抗原に対しても使用することがで
き、それによつて本発明は治療的有用性があるというこ
とが示された。 本発明は上の如く純粋に例として記述されたものであ
り、詳細の修飾は添付した特許請求の範囲中に明確に示
してあるように発明の範囲内で行い得ることは無論のこ
とと理解される。
【図面の簡単な説明】 図１はIgG分子の構造を示す模式図。 図２はB I−８抗体のVH領域と比較したNEWMのVH領域の
アミノ酸配列を示す。 図３はHuVNP遺伝子のアミノ酸及びヌクレオチド配列を
示す。 図４はHuVNP−IgEとMoVNP−IgEの結合阻害法における結
果の比較を示す。 図５は部位指向性突然変異誘起による３つのオリゴヌク
レオチドの構造を示す。 第６図は４つが１つに融合した骨核領域を含むベクター
にCDRカセツトを挿入することによつてCDR置換を構築す
るためのプロコートである。 第７図は抗体Dl.3の可変領域の配列とそれをコードする
遺伝子を示す。 図８はDl.3可変領域遺伝子のクローニングのためのプロ
トコールを示す。

Claims (1)

  1. (57)【特許請求の範囲】 １．１番目の抗体由来のIG軽鎖もしくはIG重鎖の可変領
    域における３つの相補性決定領域（CDR）の全てと、該
    １番目の抗体ではない抗体のフレームワーク領域とを含
    む改変抗体結合部位であって、該１番目の抗体の抗原結
    合特性が該CDRによって当該改変抗体結合部位に付与さ
    れている改変抗体結合部位。 ２．重鎖及び軽鎖の両方の可変領域におけるCDRが改変
    されている請求項１の改変抗体結合部位。 ３．マウス抗体由来のCDRと、ヒト抗体のフレームワー
    ク領域とを含む、請求項１または２の改変抗体結合部
    位。 ４．当該改変抗体結合部位が、天然抗体、キメラ抗体ま
    たはそれらの断片の１部を形成している、請求項１から
    ３のいずれかの改変抗体結合部位。 ５．１番目の抗体由来のIG軽鎖もしくはIG重鎖の可変領
    域における３つの相補性決定領域（CDR）の全てと、該
    １番目の抗体ではない抗体のフレームワーク領域とを含
    む改変抗体結合部位であって、該１番目の抗体の抗原結
    合特性が該CDRによって当該改変抗体結合部位に付与さ
    れている改変抗体結合部位の製造法であって、 ａ）１番目の抗体由来のCDR及び該１番目の抗体でない
    抗体のフレームワーク領域を含むIG軽鎖および／または
    IG重鎖の可変領域を少なくともコードするDNA配列、及
    びそれに作動可能なように連結した適用なプロモーター
    を含む第１の複製可能な発現ベクターを調製し； ｂ）必要ならば、上記ａ）の発現ベクターでコードされ
    るIG重鎖またはIG軽鎖にそれぞれ相補的なIG軽鎖または
    IG重鎖のそれぞれの可変領域を少なくともコードするDN
    A配列、及びそれに作動可能なように連結した適当なプ
    ロモーターを含む第２の複製可能な発現ベクターを調製
    し； ｃ）調製した第１のベクター、あるいは第１と第２の両
    方のベクターでセルラインを形質転換し； 次いで ｄ）形質転換したセルラインを培養して、該改変抗体結
    合部位を産生する； ことを含む、改変抗体結合部位の製造法。 ６．更に、工程ｄ）において産生された改変抗体結合部
    位を単離することを含む請求項５の製造法。 ７．形質転換して改変抗体結合部位を産生するセルライ
    ンが哺乳動物セルラインである請求項５または６の製造
    法。 ８．セルラインがミエローマセルラインまたはその誘導
    体である請求項７の製造法。 ９．該改変可変領域をコードするDNA配列を、合成オリ
    ゴヌクレオチドによって調製する請求項５から８のいず
    れかの製造法。 １０．改変可変領域をコードするDNA配列を、長鎖オリ
    ゴヌクレオチドを用いたプライマー誘発オリゴヌクレオ
    チド部位特異的突然変異によって調製する請求項５から
    ９のいずれかの製造法。
JP62073970A 1986-03-27 1987-03-27 組換えｄｎａ生産物及び製造法 Expired - Lifetime JP2912618B2 (ja)

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US5800815A (en) * 1903-05-05 1998-09-01 Cytel Corporation Antibodies to P-selectin and their uses
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
CA1297434C (en) * 1986-04-14 1992-03-17 Kenji Murakami Method of producing peptides, recombinant plasmid for use in the same and animal cells transformed with the same
US6054438A (en) * 1987-01-07 2000-04-25 Imperial Cancer Research Technology Limited Nucleic acid fragments encoding portions of the core protein of the human mammary epithelial mucin
DE3856559T2 (de) * 1987-05-21 2004-04-29 Micromet Ag Multifunktionelle Proteine mit vorbestimmter Zielsetzung
US5091513A (en) * 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5258498A (en) * 1987-05-21 1993-11-02 Creative Biomolecules, Inc. Polypeptide linkers for production of biosynthetic proteins
US5132405A (en) * 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
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US4978745A (en) * 1987-11-23 1990-12-18 Centocor, Inc. Immunoreactive heterochain antibodies
WO1989006692A1 (en) 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
US5720937A (en) * 1988-01-12 1998-02-24 Genentech, Inc. In vivo tumor detection assay
US5567584A (en) * 1988-01-22 1996-10-22 Zymogenetics, Inc. Methods of using biologically active dimerized polypeptide fusions to detect PDGF
DE68926888T2 (de) * 1988-01-22 1997-01-09 Zymogenetics Inc Verfahren zur Herstellung von sekretierten Rezeptoranalogen
US6018026A (en) 1988-01-22 2000-01-25 Zymogenetics, Inc. Biologically active dimerized and multimerized polypeptide fusions
US5750375A (en) * 1988-01-22 1998-05-12 Zymogenetics, Inc. Methods of producing secreted receptor analogs and biologically active dimerized polypeptide fusions
JP3095168B2 (ja) * 1988-02-05 2000-10-03 エル． モリソン，シェリー ドメイン‐変性不変部を有する抗体
AU618989B2 (en) * 1988-02-12 1992-01-16 British Technology Group Limited Improvements in or relating to antibodies
US5846534A (en) * 1988-02-12 1998-12-08 British Technology Group Limited Antibodies to the antigen campath-1
WO1989009825A1 (en) * 1988-04-16 1989-10-19 Celltech Limited Method for producing recombinant dna proteins
EP0365209A3 (en) * 1988-10-17 1990-07-25 Becton, Dickinson and Company Anti-leu 3a amino acid sequence
US5993813A (en) * 1988-10-19 1999-11-30 The Dow Chemical Company Family of high affinity, modified antibodies for cancer treatment
US6051225A (en) * 1988-10-19 2000-04-18 The Dow Chemical Company Family of high affinity, modified antibodies for cancer treatment
WO1990005144A1 (en) 1988-11-11 1990-05-17 Medical Research Council Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
DE3900534A1 (de) 1989-01-10 1990-07-12 Boehringer Mannheim Gmbh Diagnostischer nachweis unter verwendung von chimaeren antikoerpern
US5173293A (en) * 1989-02-23 1992-12-22 Becton Dickinson And Company Anti-T-cell antibodies as adjuvants
EP0460076B1 (en) * 1989-02-24 1995-11-29 The Regents Of The University Of California Genetically engineered immunoglobulins
US6291160B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for producing polymers having a preselected activity
US6291158B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertoire
US6969586B1 (en) 1989-05-16 2005-11-29 Scripps Research Institute Method for tapping the immunological repertoire
US6291161B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertiore
US6680192B1 (en) 1989-05-16 2004-01-20 Scripps Research Institute Method for producing polymers having a preselected activity
US6291159B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for producing polymers having a preselected activity
US5843693A (en) * 1989-08-16 1998-12-01 Chiron Corporation Assay method for screening for inhibitors of proTNF conversion
US6586222B1 (en) 1989-08-16 2003-07-01 Chiron Corporation Recombinant PR-3 and compositions thereof
US5998378A (en) * 1989-08-16 1999-12-07 Chiron Corporation Compositions for the inhibition of TNF hormone formation and uses thereof
GB8925590D0 (en) * 1989-11-13 1990-01-04 Central Blood Lab Authority Monoclonal antibodies
ES2075169T3 (es) * 1989-11-17 1995-10-01 Unilever Nv Agentes de union especifica.
US6750325B1 (en) 1989-12-21 2004-06-15 Celltech R&D Limited CD3 specific recombinant antibody
GB8928874D0 (en) * 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
EP0438310A1 (en) * 1990-01-19 1991-07-24 Merck & Co. Inc. Method for producing recombinant immunoglobuline
GB9014932D0 (en) * 1990-07-05 1990-08-22 Celltech Ltd Recombinant dna product and method
GB9019553D0 (en) * 1990-09-07 1990-10-24 Unilever Plc Specific binding agents
GB9020282D0 (en) 1990-09-17 1990-10-31 Gorman Scott D Altered antibodies and their preparation
GB9022545D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Culture medium
US5958413A (en) * 1990-11-01 1999-09-28 Celltech Limited Use of antibodies to TNF or fragments derived thereof and xanthine derivatives for combination therapy and compositions therefor
WO1992011272A1 (en) * 1990-12-20 1992-07-09 Ixsys, Inc. Optimization of binding proteins
AU662311B2 (en) 1991-02-05 1995-08-31 Novartis Ag Recombinant antibodies specific for a growth factor receptor
JP3854306B2 (ja) * 1991-03-06 2006-12-06 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング ヒト化及びキメラモノクローナル抗体
GB9105292D0 (en) * 1991-03-13 1991-04-24 Sandoz Ltd Improvements in or relating to organic compounds
GB9108652D0 (en) * 1991-04-23 1991-06-12 Antisoma Ltd Immunoreactive compounds
DE69229482T2 (de) 1991-04-25 1999-11-18 Chugai Seiyaku K.K., Tokio/Tokyo Rekombinierte humane antikörper gegen den humanen interleukin 6-rezeptor
US6797492B2 (en) 1991-05-17 2004-09-28 Merck & Co., Inc. Method for reducing the immunogenicity of antibody variable domains
US6800738B1 (en) 1991-06-14 2004-10-05 Genentech, Inc. Method for making humanized antibodies
WO1994004679A1 (en) * 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
AU675916B2 (en) * 1991-06-14 1997-02-27 Genentech Inc. Method for making humanized antibodies
ES2145004T3 (es) * 1991-08-21 2000-07-01 Novartis Ag Derivados de anticuerpos.
CA2078539C (en) * 1991-09-18 2005-08-02 Kenya Shitara Process for producing humanized chimera antibody
ES2136092T3 (es) * 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
GB9120467D0 (en) * 1991-09-26 1991-11-06 Celltech Ltd Anti-hmfg antibodies and process for their production
DE4133791A1 (de) * 1991-10-11 1993-04-15 Behringwerke Ag Monoklonale antikoerper gegen tumorassoziierte antigene, verfahren zu ihrer herstellung und ihre verwendung
US5837491A (en) * 1991-11-04 1998-11-17 Xoma Corporation Polynucleotides encoding gelonin sequences
US6146850A (en) * 1991-11-04 2000-11-14 Xoma Corporation Proteins encoding gelonin sequences
US5621083A (en) * 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
WO1993010221A1 (en) * 1991-11-13 1993-05-27 The Regents Of The University Of California Chimeric murine/human anti-idiotype monoclonal antibodies
ATE408012T1 (de) 1991-12-02 2008-09-15 Medical Res Council Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
EP1696031B1 (en) 1991-12-02 2010-04-07 MedImmune Limited Production of anti-self antibodies from antibody segment repertoires and displayed on phage
GB9125979D0 (en) * 1991-12-06 1992-02-05 Wellcome Found Antibody
JPH05244982A (ja) * 1991-12-06 1993-09-24 Sumitomo Chem Co Ltd 擬人化ｂ−ｂ１０
DE69233204T2 (de) * 1991-12-13 2004-07-15 Xoma Corp., Berkeley Verfahren und materialien zur herstellung von modifizierten variablen antikörperdomänen und ihre therapeutische verwendung
US5869619A (en) * 1991-12-13 1999-02-09 Xoma Corporation Modified antibody variable domains
US5777085A (en) * 1991-12-20 1998-07-07 Protein Design Labs, Inc. Humanized antibodies reactive with GPIIB/IIIA
ES2179824T3 (es) * 1991-12-20 2003-02-01 Yamanouchi Pharma Co Ltd Anticuerpos humanizados reactivos contra el antigeno gpiib/iiia.
ATE150319T1 (de) † 1992-01-13 1997-04-15 Biogen Inc Behandlung von asthma
KR0150060B1 (ko) 1992-02-06 1998-08-17 에릭 에스. 딕커 사람 인터루킨-5에 대한 인간화 모노클로날 항체의 고안, 클로닝 및 발현
CA2090515C (en) 1992-02-28 2002-10-29 Kazuhiko Kimachi Anti-feline calicivirus recombinant antibody and gene fragment encoding the same
US5714350A (en) 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
GB9206422D0 (en) 1992-03-24 1992-05-06 Bolt Sarah L Antibody preparation
US7754211B2 (en) 1992-04-10 2010-07-13 Research Development Foundation Immunotoxins directed against c-erbB-2(HER-2/neu) related surface antigens
US6033667A (en) * 1992-05-05 2000-03-07 Cytel Corporation Method for detecting the presence of P-selectin
JPH0630788A (ja) * 1992-07-16 1994-02-08 Otsuka Pharmaceut Co Ltd ヒトインターロイキン−１に対する組換え抗体
EP1621554B2 (en) * 1992-08-21 2012-08-29 Vrije Universiteit Brussel Immunoglobulins devoid of light chains
US6765087B1 (en) 1992-08-21 2004-07-20 Vrije Universiteit Brussel Immunoglobulins devoid of light chains
US5639641A (en) * 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
US5958708A (en) * 1992-09-25 1999-09-28 Novartis Corporation Reshaped monoclonal antibodies against an immunoglobulin isotype
US6066718A (en) * 1992-09-25 2000-05-23 Novartis Corporation Reshaped monoclonal antibodies against an immunoglobulin isotype
US5844094A (en) * 1992-09-25 1998-12-01 Commonwealth Scientific And Industrial Research Organization Target binding polypeptide
US6270766B1 (en) 1992-10-08 2001-08-07 The Kennedy Institute Of Rheumatology Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease
US6030797A (en) * 1992-10-08 2000-02-29 Dade Behring Marburg Gmbh Monoclonal antibodies against tumor-associated antigens, processes for the preparation thereof and the use thereof
TW378213B (en) * 1992-11-04 2000-01-01 Shionogy Seiyaku Kk Basophil-binding monoclonal antibody, method for separation of basophils, method for chemical mediator released from basophils, and testing method for release of basophil-derived chemical mediators
GB9223377D0 (en) 1992-11-04 1992-12-23 Medarex Inc Humanized antibodies to fc receptors for immunoglobulin on human mononuclear phagocytes
US5792852A (en) * 1992-11-16 1998-08-11 Cancer Research Fund Of Contra Costa Polynucleotides encoding modified antibodies with human milk fat globule specificity
US6281335B1 (en) 1993-10-08 2001-08-28 Coulter Corporation Hybridoma and anti-KC-4 humanized monoclonal antibody
US5804187A (en) 1992-11-16 1998-09-08 Cancer Research Fund Of Contra Costa Modified antibodies with human milk fat globule specificity
JP3919830B2 (ja) 1992-11-28 2007-05-30 財団法人化学及血清療法研究所 抗ネコヘルペスウイルス−１組換え抗体および該抗体をコードする遺伝子断片
US6307026B1 (en) * 1992-12-10 2001-10-23 Celltech Limited Humanized antibodies directed against A33 antigen
AU688751B2 (en) 1993-01-12 1998-03-19 Biogen Idec Ma Inc. Recombinant anti-VLA4 antibody molecules
DE69333627T2 (de) * 1993-01-14 2005-09-22 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Rekombinanter anti-hiv antikörper und seine herstellung
ATE256751T1 (de) * 1993-03-11 2004-01-15 Chemo Sero Therapeut Res Inst Monoklonaler anti-hiv antikörper
WO1994027639A1 (en) * 1993-05-26 1994-12-08 Thomas Jefferson University Methods for treating post-exposure rabies and anti-rabies compositions
US6180377B1 (en) * 1993-06-16 2001-01-30 Celltech Therapeutics Limited Humanized antibodies
US6046012A (en) * 1993-07-19 2000-04-04 Hoffmann-La Roche Inc. Antibody to IL-12 receptor
GB9325182D0 (en) * 1993-12-08 1994-02-09 T Cell Sciences Inc Humanized antibodies or binding proteins thereof specific for t cell subpopulations exhibiting select beta chain variable regions
US5840299A (en) * 1994-01-25 1998-11-24 Athena Neurosciences, Inc. Humanized antibodies against leukocyte adhesion molecule VLA-4
US7435802B2 (en) 1994-01-25 2008-10-14 Elan Pharaceuticals, Inc. Humanized anti-VLA4 immunoglobulins
CA2185162A1 (en) 1994-03-07 1995-09-14 Robert F. Halenback (Deceased) Compositions for the inhibition of tnf formation and uses thereof
CA2185116A1 (en) * 1994-03-08 1995-09-14 Thomas P. Wallace Recombinant humanized anti-fb5 antibodies
US6310185B1 (en) * 1994-03-08 2001-10-30 Memorial Sloan Kettering Cancer Center Recombinant human anti-Lewis Y antibodies
US5597710A (en) * 1994-03-10 1997-01-28 Schering Corporation Humanized monoclonal antibodies against human interleukin-4
USRE39548E1 (en) 1994-06-17 2007-04-03 Celltech R&D Limited Interleukin-5 specific recombinant antibodies
GB9412230D0 (en) * 1994-06-17 1994-08-10 Celltech Ltd Interleukin-5 specific recombiant antibodies
CU22615A1 (es) 1994-06-30 2000-02-10 Centro Inmunologia Molecular Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos
US6010861A (en) * 1994-08-03 2000-01-04 Dgi Biotechnologies, Llc Target specific screens and their use for discovering small organic molecular pharmacophores
US6056957A (en) * 1994-08-04 2000-05-02 Schering Corporation Humanized monoclonal antibodies against human interleukin-5
US8771694B2 (en) 1994-08-12 2014-07-08 Immunomedics, Inc. Immunoconjugates and humanized antibodies specific for B-cell lymphoma and leukemia cells
CA2195557C (en) * 1994-08-12 2006-10-17 Shui-On Leung Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells
AU3415395A (en) * 1994-08-26 1996-03-22 Eli Lilly And Company Antibody constructs with cdr switched variable regions
US5874540A (en) 1994-10-05 1999-02-23 Immunomedics, Inc. CDR-grafted type III anti-CEA humanized mouse monoclonal antibodies
US7820798B2 (en) 1994-11-07 2010-10-26 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
US7597886B2 (en) 1994-11-07 2009-10-06 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
US6017697A (en) 1994-11-14 2000-01-25 Eli Lilly And Company Excitatory amino acid receptor protein and related nucleic acid compounds
CA2210620C (en) * 1995-01-18 2004-06-22 Boehringer Mannheim Gmbh Anti-cd 30 antibodies preventing proteolytic cleavage and release of membrane-bound cd 30 antigen
US5853721A (en) * 1995-01-31 1998-12-29 Hoffmann-La Roche Inc. Antibody to interleukin-12 receptor
US6066322A (en) * 1995-03-03 2000-05-23 Millennium Pharmaceuticals, Inc. Methods for the treatment of immune disorders
US6455685B1 (en) 1995-03-03 2002-09-24 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of immune disorders
US5705154A (en) * 1995-03-08 1998-01-06 Schering Corporation Humanized monoclonal antibodies against human interleukin-4
US5869046A (en) * 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
US5739277A (en) * 1995-04-14 1998-04-14 Genentech Inc. Altered polypeptides with increased half-life
US5747035A (en) * 1995-04-14 1998-05-05 Genentech, Inc. Polypeptides with increased half-life for use in treating disorders involving the LFA-1 receptor
US6096871A (en) * 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
US7429646B1 (en) 1995-06-05 2008-09-30 Human Genome Sciences, Inc. Antibodies to human tumor necrosis factor receptor-like 2
AUPO591797A0 (en) 1997-03-27 1997-04-24 Commonwealth Scientific And Industrial Research Organisation High avidity polyvalent and polyspecific reagents
WO1996040210A1 (en) * 1995-06-07 1996-12-19 Imclone Systems Incorporated Antibody and antibody fragments for inhibiting the growth of tumors
US6113898A (en) 1995-06-07 2000-09-05 Idec Pharmaceuticals Corporation Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies
US7153508B2 (en) 1995-06-07 2006-12-26 Biogen Idec Inc. Treatment of B cell lymphoma using anti-CD80 antibodies that do not inhibit the binding of CD80 to CTLA-4
US7175847B1 (en) 1995-06-07 2007-02-13 Biogen Idec Inc. Treating intestinal inflammation with anti-CD80 antibodies that do not inhibit CD80 binding to CTLA-4
CA2229043C (en) * 1995-08-18 2016-06-07 Morphosys Gesellschaft Fur Proteinoptimierung Mbh Protein/(poly)peptide libraries
US7368111B2 (en) 1995-10-06 2008-05-06 Cambridge Antibody Technology Limited Human antibodies specific for TGFβ2
EP0781847A1 (en) 1995-11-06 1997-07-02 MERCK PATENT GmbH Humanized monoclonal antibody
US7888466B2 (en) 1996-01-11 2011-02-15 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
GB9600660D0 (en) 1996-01-12 1996-03-13 Ciba Geigy Ag Protein
US6254868B1 (en) 1996-03-20 2001-07-03 Immunomedics, Inc. Glycosylated humanized B-cell specific antibodies
US7964190B2 (en) 1996-03-22 2011-06-21 Human Genome Sciences, Inc. Methods and compositions for decreasing T-cell activity
US6635743B1 (en) 1996-03-22 2003-10-21 Human Genome Sciences, Inc. Apoptosis inducing molecule II and methods of use
EP1854481B1 (en) 1996-04-23 2014-07-16 Chugai Seiyaku Kabushiki Kaisha Cerebral stroke/cerebral edema preventive or remedy containing IL-8 binding inhibitor as active ingredient
US6713305B1 (en) 1996-04-29 2004-03-30 Novartis Ag Metastasis-associated antigen and antibodies thereto
GB9610967D0 (en) 1996-05-24 1996-07-31 Cambridge Antibody Tech Specific binding members,materials and methods
CA2257357C (en) 1996-06-07 2010-04-13 Neorx Corporation Humanized antibodies with modified glycosylation
GB9712818D0 (en) 1996-07-08 1997-08-20 Cambridge Antibody Tech Labelling and selection of specific binding molecules
US6833255B1 (en) 1996-07-24 2004-12-21 Novartis, Ag Drosophila melanogaster p70 S6 kinase
US6534311B2 (en) 1996-07-24 2003-03-18 Novartis Ag Drosophila melanogaster p70S6 kinase
US7147851B1 (en) 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
EP1642908A2 (en) * 1996-09-02 2006-04-05 Okumura, Ko Apoptosis-induced site from fas ligand
US7883872B2 (en) 1996-10-10 2011-02-08 Dyadic International (Usa), Inc. Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose
US5977319A (en) * 1996-10-21 1999-11-02 Cambridge Antibody Technology Limited Specific binding members for estradiol; materials and methods
US6455040B1 (en) 1997-01-14 2002-09-24 Human Genome Sciences, Inc. Tumor necrosis factor receptor 5
US7452538B2 (en) 1997-01-28 2008-11-18 Human Genome Sciences, Inc. Death domain containing receptor 4 antibodies and methods
US6433147B1 (en) 1997-01-28 2002-08-13 Human Genome Sciences, Inc. Death domain containing receptor-4
US8329179B2 (en) 1997-01-28 2012-12-11 Human Genome Sciences, Inc. Death domain containing receptor 4 antibodies and methods
PT1012274E (pt) 1997-01-28 2007-08-14 Craig A Rosen Receptor 4 contendo um domínio de morte (dm4; receptor de morte 4), membro da super-família do ftn e ligação a liart (ap02)
US7122636B1 (en) * 1997-02-21 2006-10-17 Genentech, Inc. Antibody fragment-polymer conjugates and uses of same
AU747898B2 (en) * 1997-03-03 2002-05-30 Bristol-Myers Squibb Company Monoclonal antibodies to human CD6
US7749498B2 (en) 1997-03-10 2010-07-06 Genentech, Inc. Antibodies for inhibiting blood coagulation and methods of use thereof
US5986065A (en) 1997-03-10 1999-11-16 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
US20030109680A1 (en) 2001-11-21 2003-06-12 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
US20060235209A9 (en) 1997-03-10 2006-10-19 Jin-An Jiao Use of anti-tissue factor antibodies for treating thromboses
US6872568B1 (en) 1997-03-17 2005-03-29 Human Genome Sciences, Inc. Death domain containing receptor 5 antibodies
EP2322216A1 (en) 1997-03-21 2011-05-18 Chugai Seiyaku Kabushiki Kaisha A preventive or therapeutic agent for sensitized T cell-mediated diseases comprising IL-6 antagonist as an active ingredient
GB9706957D0 (en) 1997-04-05 1997-05-21 Smithkline Beecham Plc Formulation
US20020032315A1 (en) 1997-08-06 2002-03-14 Manuel Baca Anti-vegf antibodies
DE122007000021I1 (de) 1997-04-07 2007-05-24 Genentech Inc Anti-vefg Antibodies
US7365166B2 (en) 1997-04-07 2008-04-29 Genentech, Inc. Anti-VEGF antibodies
US6884879B1 (en) 1997-04-07 2005-04-26 Genentech, Inc. Anti-VEGF antibodies
JP4566290B2 (ja) 1997-04-30 2010-10-20 ツインストランド・ホールディングス・インコーポレイテッド 癌、ウイルスまたは寄生虫感染を治療するためのリシン様毒素変異体
GB9710154D0 (en) * 1997-05-16 1997-07-09 Medical Res Council Detection of retroviruses
DE69833755T2 (de) 1997-05-21 2006-12-28 Biovation Ltd. Verfahren zur herstellung von nicht-immunogenen proteinen
US5994511A (en) 1997-07-02 1999-11-30 Genentech, Inc. Anti-IgE antibodies and methods of improving polypeptides
US6172213B1 (en) 1997-07-02 2001-01-09 Genentech, Inc. Anti-IgE antibodies and method of improving polypeptides
US6103466A (en) * 1997-07-14 2000-08-15 University Of Liege Double-muscling in mammals
PT2045322E (pt) 1997-07-14 2015-10-16 Université de Liège Musculatura dupla em mamíferos
ATE395933T1 (de) 1997-08-15 2008-06-15 Chugai Pharmaceutical Co Ltd Präventiva oder arzneien enthaltend neutralisierende anti-il6-rezeptor antikörper zur reduktion urinären proteins bei systemischen lupus erythematosus
ATE350472T1 (de) 1997-10-21 2007-01-15 Univ Glasgow Jmy, mit-aktivator für p300/cbp, dafür kodierendenucleinsäure und deren verwendungen
CA2693296C (en) 1997-12-08 2013-09-10 Merck Patent Gmbh Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation
GB9726398D0 (en) 1997-12-12 1998-02-11 Isis Innovation Polypeptide and coding sequences
US20030170248A1 (en) 1997-12-23 2003-09-11 Jeffrey R. Stinson Humanized monoclonal antibodies that protect against shiga toxin induced disease
EP1060261B1 (en) 1998-03-02 2010-05-05 Massachusetts Institute of Technology Poly zinc finger proteins with improved linkers
AU3072799A (en) 1998-03-19 1999-10-11 Human Genome Sciences, Inc. Cytokine receptor common gamma chain like
DK1069185T3 (da) 1998-04-03 2011-06-27 Chugai Pharmaceutical Co Ltd Humaniseret antistof mod human vævsfaktor (TF) og fremgangsmåde til at konstruere humaniseret antistof
JP2000000097A (ja) 1998-06-15 2000-01-07 Nippon Zoki Pharmaceut Co Ltd Ｎｅｆ結合蛋白質、該蛋白質をコードするＤＮＡ並びに該蛋白質に対するモノクローナル抗体
EP1096952B1 (en) 1998-07-15 2008-05-21 The Brigham And Women's Hospital, Inc. Polysaccharide vaccine for staphylococcal infections
US8609614B2 (en) 1998-07-22 2013-12-17 Vanderbilt University GBS toxin receptor compositions and methods of use
US6312689B1 (en) 1998-07-23 2001-11-06 Millennium Pharmaceuticals, Inc. Anti-CCR2 antibodies and methods of use therefor
US6228360B1 (en) 1998-08-19 2001-05-08 Ajinomoto Co., Inc. Antithrombotic agent and humanized anti-von Willebrand factor monoclonal antibody
DE69925133T2 (de) 1998-08-27 2006-01-19 Spirogen Ltd., Ryde Pyrrolobenzodiazepine
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
GB9818731D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Compounds
DK1113810T3 (da) 1998-09-14 2009-04-06 Univ Texas Fremgangsmåder til behandling af multipelt myelom og myelom-induceret knogleresorption under anvendelse af antagonister af integrin/receptor-binding
GB9820525D0 (en) 1998-09-21 1998-11-11 Allergy Therapeutics Ltd Formulation
DE69922978T2 (de) 1998-10-06 2005-12-08 Emalfarb, Mark Aaron, Jupiter Transformationsystem in filamentösen fungiziden chrysosporium-wirtszellen
EP1939215A1 (en) 1998-10-22 2008-07-02 The University of Montana Omp85 proteins of neisseria gonorrhoeae and neisseria meningitidis, compositions containing same and methods of use thereof
US6818749B1 (en) 1998-10-31 2004-11-16 The United States Of America As Represented By The Department Of Health And Human Services Variants of humanized anti carcinoma monoclonal antibody cc49
EP1950300A3 (en) 1998-11-18 2011-03-23 Genentech, Inc. Antibody variants with higher binding affinity compared to parent antibodies
US20030035798A1 (en) 2000-08-16 2003-02-20 Fang Fang Humanized antibodies
AU2367600A (en) 1998-12-16 2000-07-03 Chiron Corporation Human cyclin-dependent kinase ((hpnqalre))
EE05627B1 (et) 1998-12-23 2013-02-15 Pfizer Inc. CTLA-4 vastased inimese monoklonaalsed antikehad
US7109003B2 (en) 1998-12-23 2006-09-19 Abgenix, Inc. Methods for expressing and recovering human monoclonal antibodies to CTLA-4
EP1159300A2 (en) 1999-02-12 2001-12-05 Genetics Institute, Inc. Humanized immunoglobulin reactive with b7 molecules and methods of treatment therewith
US6972125B2 (en) 1999-02-12 2005-12-06 Genetics Institute, Llc Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith
AU3501700A (en) 1999-02-26 2000-09-14 Human Genome Sciences, Inc. Human endokine alpha and methods of use
RS50086B (sr) 1999-04-22 2009-01-22 Biogen Idec Ma Inc., Upotreba antagonista subjedinica alfa-4 integrina za pripremanje farmaceutskog preparata za tretiranje fibroze
US6492497B1 (en) 1999-04-30 2002-12-10 Cambridge Antibody Technology Limited Specific binding members for TGFbeta1
EE200100603A (et) 1999-05-14 2003-02-17 Imclone Systems Incorporated Inimese refraktaarsete kasvajate ravi epidermaalse kasvufaktori retseptori antagonistidega
CA2305716A1 (en) 1999-05-28 2000-11-28 University Of Guelph Method for assay of wbpm
TR200103432T2 (tr) 1999-06-01 2002-10-21 Biogen, Inc. Engelleyici monoklonal VLA-1 antikoru ve enflamasyonlu hastalıkların tedavisinde kullanımı.
US7534605B2 (en) 1999-06-08 2009-05-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases
CN1370076A (zh) 1999-08-23 2002-09-18 中外制药株式会社 Hm1.24抗原的表达增强剂
KR100942863B1 (ko) 1999-08-24 2010-02-17 메다렉스, 인코포레이티드 인간 씨티엘에이-4 항체 및 그의 용도
US6323334B1 (en) 1999-09-24 2001-11-27 Millennium Pharmaceuticals, Inc. Nucleic acid molecules encoding a 103 gene product and uses therefor
CA2387576C (en) 1999-10-18 2011-05-10 Prince Henry's Institute Of Medical Research Immuno-interactive fragments of the .alpha.c subunit of inhibin
US6342587B1 (en) 1999-10-22 2002-01-29 Ludwig Institute For Cancer Research A33 antigen specific immunoglobulin products and uses thereof
US6346249B1 (en) 1999-10-22 2002-02-12 Ludwig Institute For Cancer Research Methods for reducing the effects of cancers that express A33 antigen using A33 antigen specific immunoglobulin products
DK2140881T3 (da) 1999-12-16 2013-05-06 Biogen Idec Inc Fremgangsmåder til behandling af iskæmisk eller hæmoragisk læsion i centralnervesystemet ved anvendelse af anti-alpha-4-integrin-antagonister
GB0000891D0 (en) 2000-01-14 2000-03-08 Allergy Therapeutics Ltd Formulation
PL216780B1 (pl) 2000-01-25 2014-05-30 Univ Queensland Of Santa Lucia Wyizolowane białka zawierające konserwatywne obszary antygenu powierzchniowego NhhA z Neisseria meningitidis, białka fuzyjne, kompozycja farmaceutyczna, przeciwciało monoklonalne lub wiążący antygen fragment przeciwciała monoklonalnego, wyizolowany kwas nukleinowy, konstrukt ekspresyjny, komórka gospodarza, sposób wytwarzania rekombinowanego białka, sposób wykrywania N. meningitidis w próbce biologicznej, sposób diagnozowania zakażenia N. meningitidis oraz sposób wykrywania N. meningitidis w próbce biologicznej uzyskanej od pacjenta oraz zastosowanie wyizolowanego białka, białka fuzyjnego i konstruktu ekspresyjnego
AU2002219944B2 (en) 2000-11-28 2008-02-21 Medimmune, Llc Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
US7740841B1 (en) 2000-01-28 2010-06-22 Sunnybrook Health Science Center Therapeutic method for reducing angiogenesis
DE60141938D1 (de) 2000-02-02 2010-06-10 Univ Vanderbilt Verfahren zur vorbeugung und linderung angiogener erkrankungen durch impfung mit dem rezeptor für gbs-toxin (cm101)
EP1259544B1 (en) 2000-02-11 2011-08-24 Biogen Idec MA Inc. Heterologous polypeptide of the tnf family
ATE336514T1 (de) 2000-02-11 2006-09-15 Merck Patent Gmbh Steigerung der zirkulierenden halbwertzeit von auf antikörpern basierenden fusionsproteinen
IT1317835B1 (it) 2000-02-15 2003-07-15 San Raffaele Centro Fond Citochine modificate per uso nella terapia del cancro.
CA2400622A1 (en) 2000-02-24 2001-08-30 Eidgenossische Technische Hochschule Zurich Antibody specific for the ed-b domain of fibronectin, conjugates comprising said antibody, and their use for the detection and treatment of angiogenesis
US20040002068A1 (en) 2000-03-01 2004-01-01 Corixa Corporation Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
EP1278544A4 (en) 2000-04-12 2004-08-18 Human Genome Sciences Inc ALBUMIN FUSION PROTEINS
US20010046496A1 (en) 2000-04-14 2001-11-29 Brettman Lee R. Method of administering an antibody
US7632929B2 (en) 2000-04-20 2009-12-15 The Board Of Trustees Of The University Of Arkansas Methamphetamine-like hapten compounds, linkers, carriers and compositions and uses thereof
US7560534B2 (en) 2000-05-08 2009-07-14 Celldex Research Corporation Molecular conjugates comprising human monoclonal antibodies to dendritic cells
US7071319B2 (en) 2000-05-16 2006-07-04 Thomas Jefferson University Recombinant antibodies, and compositions and methods for making and using the same
IL152825A (en) 2000-05-16 2009-07-20 Univ Jefferson Rabies virus-specific neutralizing human monoclonal antibodies and nucleic acids and related methods
GB0013810D0 (en) 2000-06-06 2000-07-26 Celltech Chiroscience Ltd Biological products
US20030031675A1 (en) 2000-06-06 2003-02-13 Mikesell Glen E. B7-related nucleic acids and polypeptides useful for immunomodulation
EP1286682B1 (en) 2000-06-08 2010-03-03 Immune Disease Institute, Inc. Methods and compositions for inhibiting immunoglobulin-mediated-reperfusion injury
WO2001096528A2 (en) 2000-06-15 2001-12-20 Human Genome Sciences, Inc. Human tumor necrosis factor delta and epsilon
WO2002002641A1 (en) 2000-06-16 2002-01-10 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to blys
TWI224620B (en) 2000-08-11 2004-12-01 Kirin Brewery Polypeptides controlling phosphoric acid metabolism, calcium metabolism, calcification and vitamin D metabolism and DNAS encoding the same
GB0022748D0 (en) 2000-09-15 2000-11-01 Allied Therapeutics Ltd Reducing the content of cells in a biological sample
ATE352040T1 (de) 2000-11-17 2007-02-15 Univ Rochester In-vitro verfahren zur herstellung und identifizierung von immunglobulin moleküle in eukaryotischen zellen
US6989247B2 (en) 2000-11-28 2006-01-24 Celltech R & D, Inc. Compositions and methods for diagnosing or treating psoriasis
EP1355919B1 (en) 2000-12-12 2010-11-24 MedImmune, LLC Molecules with extended half-lives, compositions and uses thereof
WO2002070678A2 (en) 2001-02-05 2002-09-12 Bayer Aktiengesellschaft Regulation of human serine/threonine protein kinase
JP3986439B2 (ja) 2001-02-07 2007-10-03 中外製薬株式会社 造血器腫瘍の治療剤
AU2002250032B2 (en) 2001-02-09 2008-06-05 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
WO2002069232A2 (en) 2001-02-19 2002-09-06 Merck Patent Gmbh Method for identification of t-cell epitopes and use for preparing molecules with reeduced immunogenicity
AU2002248571B2 (en) 2001-03-07 2007-01-18 Merck Patent Gmbh Expression technology for proteins containing a hybrid isotype antibody moiety
US8231878B2 (en) 2001-03-20 2012-07-31 Cosmo Research & Development S.P.A. Receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
US8981061B2 (en) 2001-03-20 2015-03-17 Novo Nordisk A/S Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof
WO2002079415A2 (en) 2001-03-30 2002-10-10 Lexigen Pharmaceuticals Corp. Reducing the immunogenicity of fusion proteins
UA80091C2 (en) 2001-04-02 2007-08-27 Chugai Pharmaceutical Co Ltd Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
CA2440474A1 (en) 2001-04-05 2002-10-17 Virginia Mason Research Center Methods of mhc class ii epitope mapping, detection of autoimmune t cells and antigens, and autoimmune treatment
JP2004536579A (ja) 2001-04-13 2004-12-09 ヒューマン　ジノーム　サイエンシーズ，　インコーポレイテッド 血管内皮増殖因子２
EA006705B1 (ru) 2001-04-13 2006-02-24 Байоджен Айдек Ма Инк. Антитела против vla-1
JP4309662B2 (ja) 2001-05-03 2009-08-05 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 腫瘍特異的組換え抗体およびその使用
GB0111628D0 (en) 2001-05-11 2001-07-04 Scancell Ltd Binding member
US6972324B2 (en) 2001-05-18 2005-12-06 Boehringer Ingelheim Pharmaceuticals, Inc. Antibodies specific for CD44v6
US7348003B2 (en) 2001-05-25 2008-03-25 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors
MXPA03010747A (es) 2001-05-25 2004-03-02 Human Genome Sciences Inc Anticuerpos que se unen inmunoespecificamente a receptores de ligando inductor de apoptosis relacionado con factor de necrosis tumoral.
US7361341B2 (en) 2001-05-25 2008-04-22 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to trail receptors
IL158969A0 (en) 2001-06-01 2004-05-12 Cornell Res Foundation Inc Modified antibodies to prostate-specific membrane antigen and uses thereof
NZ530122A (en) 2001-06-26 2008-03-28 Agen Biomedical Ltd Variant of an immunointeractive molecule comprising a portion having specificity for cross-linked fibrin derivatives from an immunointeractive molecule from an animal or avian
US7321026B2 (en) 2001-06-27 2008-01-22 Skytech Technology Limited Framework-patched immunoglobulins
JP2005522192A (ja) 2001-07-19 2005-07-28 パーラン セラピューティクス， インコーポレイテッド マルチマータンパク質およびマルチマータンパク質を作製および使用する方法
US6867189B2 (en) 2001-07-26 2005-03-15 Genset S.A. Use of adipsin/complement factor D in the treatment of metabolic related disorders
JP4628674B2 (ja) 2001-09-12 2011-02-09 ザ ウォルター アンド エリザ ホール インスティテュートオブ メディカル リサーチ 診断および治療の方法ならびにそのために有用な作用物質
PT1434871T (pt) 2001-09-20 2017-04-05 Immunex Corp Seleção de células que expressam polipéptidos heteroméricos
EP1431310A4 (en) 2001-09-25 2005-03-23 Immuno Biological Lab Co Ltd ANTI-OSTEOPONTIN RECOMBINANT ANTIBODY AND USE THEREOF
NZ532021A (en) 2001-10-04 2008-05-30 Genetics Inst Llc Methods and compositions for modulating interleukin-21 receptor activity
GB0124317D0 (en) 2001-10-10 2001-11-28 Celltech R&D Ltd Biological products
US20030190705A1 (en) 2001-10-29 2003-10-09 Sunol Molecular Corporation Method of humanizing immune system molecules
TWI338009B (en) 2001-10-29 2011-03-01 Genentech Inc Antibodies for inhibiting blood coagulation and methods of use thereof
GB0126378D0 (en) 2001-11-02 2002-01-02 Oxford Biomedica Ltd Antigen
EP1944043A1 (en) 2001-11-21 2008-07-16 The Trustees of the University of Pennsylvania Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use
NZ532383A (en) 2001-11-21 2007-03-30 Univ Pennsylvania Pan-7 simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use
GB0127983D0 (en) 2001-11-22 2002-01-16 Neutec Pharma Plc Treatment of micro-organism infection
EP2354791A1 (en) 2001-12-04 2011-08-10 Merck Patent GmbH Immunocytokines with modulated selectivity
GB0129105D0 (en) 2001-12-05 2002-01-23 Celltech R&D Ltd Expression control using variable intergenic sequences
GB0130543D0 (en) 2001-12-20 2002-02-06 Univ Cambridge Tech Human antibodies and their use
EP2277910A1 (en) 2001-12-21 2011-01-26 Human Genome Sciences, Inc. Albumin fusion proteins
EP1466925B1 (en) 2001-12-28 2009-09-02 Kyowa Hakko Kirin Co., Ltd. Antibodies against fibroblast growth factor 23
US20050171339A1 (en) 2001-12-28 2005-08-04 Izumi Sugo Method of stabilizing protein
EP1475101B1 (en) 2002-02-14 2010-10-27 Chugai Seiyaku Kabushiki Kaisha Antibody-containing solution pharmaceuticals
DK2508596T3 (en) 2002-02-21 2015-10-19 Inst Virology MN / CA IX-specific monoclonal antibodies generated from MN / CA IX-poor mice, as well as methods of use.
US8491906B2 (en) 2002-03-11 2013-07-23 Philogen S.P.A. Selective targeting of tumor vasculature using antibody molecules
NZ535425A (en) 2002-03-13 2008-05-30 Biogen Idec Inc Anti-alphavbeta6 antibodies
ATE500273T1 (de) 2002-03-20 2011-03-15 Ucb Pharma Sa Methoden zur analyse von antikörperdisulfidisomere
EP1499352A4 (en) 2002-04-12 2006-10-11 Medimmune Inc ANTI-INTERLEUKIN-9 RECOMBINANT ANTIBODIES
GB0209896D0 (en) 2002-04-30 2002-06-05 Molmed Spa Conjugate
JP2006511194A (ja) 2002-05-02 2006-04-06 デイビッド ラブジョイ テネウリンｃ末端関連ペプチド（ｔｃａｐ）並びにこれらに関連する方法および使用
GB0210121D0 (en) 2002-05-02 2002-06-12 Celltech R&D Ltd Biological products
EP1507866B1 (en) 2002-05-14 2010-07-07 Martek Biosciences Corporation Carotene synthase gene and uses therefor
EP1900827A3 (en) 2002-05-21 2008-04-16 Bayer HealthCare AG Methods and compositions for the prediction, diagnosis, prognosis, prevention and treatment of malignant neoplasia
AU2003228768B2 (en) 2002-05-22 2009-02-05 The Cleveland Clinic Foundation Induction and maintenance of tolerance to composite tissue allografts
EP1534753B1 (en) 2002-05-28 2011-08-03 UCB Pharma, S.A. Peg positional isomer of an anti-tnfalpha antibody (cdp870)
CN100418981C (zh) 2002-06-10 2008-09-17 瓦西尼斯公司 在乳腺癌和膀胱癌中差异表达的基因及编码多肽
US7425618B2 (en) 2002-06-14 2008-09-16 Medimmune, Inc. Stabilized anti-respiratory syncytial virus (RSV) antibody formulations
GB0213745D0 (en) 2002-06-14 2002-07-24 Univ Edinburgh Enzyme
EP1521770B1 (en) 2002-06-14 2008-11-26 Monier Tadros Method for the production of protamine
EP1532162B1 (en) 2002-06-28 2013-08-07 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Humanized anti-tag-72 cc49 for diagnosis and therapy of human tumors
US7435419B2 (en) 2002-07-19 2008-10-14 Beth Israel Deaconess Medical Center Methods of diagnosing and treating pre-eclampsia or eclampsia
EA200500232A1 (ru) 2002-07-19 2005-12-29 Бет Изрейэл Диконисс Медикал Сентер Способы диагностики и лечения преэклампсии или эклампсии
TWI323265B (en) 2002-08-06 2010-04-11 Glaxo Group Ltd Antibodies
US8044180B2 (en) * 2002-08-14 2011-10-25 Macrogenics, Inc. FcγRIIB specific antibodies and methods of use thereof
ATE536188T1 (de) 2002-08-14 2011-12-15 Macrogenics Inc Fcgammariib-spezifische antikörper und verfahren zur verwendung davon
US20060058511A1 (en) 2002-08-27 2006-03-16 Chugai Seiyaku Kabushiki Kaisha Method for stabilizing protein solution preparation
EP1542609B8 (en) 2002-08-29 2013-02-20 CytoCure LLC Pharmaceutical compositions comprising Interferon beta for use in treating melanoma
JP5525118B2 (ja) 2002-09-11 2014-06-18 中外製薬株式会社 タンパク質精製方法
CN101972478B (zh) 2002-10-08 2012-10-31 免疫医疗公司 抗体治疗
GB0228832D0 (en) 2002-12-10 2003-01-15 Novartis Ag Organic compound
RS20050300A (en) 2002-10-16 2007-08-03 Euro-Celtique S.A., Antibodies that bind cell-associated ca 125/0772p and methods of use thereof
WO2004043405A2 (en) 2002-11-12 2004-05-27 The Brigham And Women's Hospital, Inc. Polysaccharide vaccine for staphylococcal infections
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
JP4741242B2 (ja) 2002-11-26 2011-08-03 アボット バイオセラピューティクス コーポレイション 新脈管形成を調節するα５β１インテグリンへのキメラ及びヒト化抗体
EP2363410B1 (en) 2002-11-27 2017-10-11 Minerva Biotechnologies Corporation Isoforms of MUC1
WO2004055056A1 (en) 2002-12-17 2004-07-01 Merck Patent Gmbh Humanized antibody (h14.18) of the mouse 14.18 antibody binding to gd2 and its fusion with il-2
AU2003299778A1 (en) 2002-12-20 2004-07-22 Protein Design Labs, Inc. Antibodies against gpr64 and uses thereof
ES2897506T3 (es) 2003-01-09 2022-03-01 Macrogenics Inc Identificación y modificación de anticuerpos con regiones Fc variantes y métodos de utilización de los mismos
EP1592387A4 (en) 2003-01-24 2009-05-06 Elan Pharm Inc COMPOSITION AND TREATMENT OF DEMYELINATING DISEASES AND PARALYSIS BY ADMINISTRATION OF REMYELINATING AGENTS
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
PT2000481E (pt) 2003-02-01 2016-06-17 Tanox Inc Anticorpos anti-ige humana de alta afinidade
AU2003900481A0 (en) 2003-02-05 2003-02-20 Queensland University Of Technology Synthetic modulators of cell migration and growth
US20100143442A1 (en) 2003-02-05 2010-06-10 Queensland University Of Technology Growth factor complexes and modulation of cell migration and growth
EP2241330A1 (en) 2003-02-14 2010-10-20 The Curators Of The University Of Missouri Contraceptive methods and compositions related to proteasomal interference
AU2004213053C1 (en) 2003-02-20 2009-07-16 Seagen Inc. Anti-CD70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders
ATE479754T1 (de) 2003-03-19 2010-09-15 Biogen Idec Inc Nogo rezeptor bindendes protein
EP1608983A2 (en) 2003-03-20 2005-12-28 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research Materials and methods for modulating cell motility
AU2003901325A0 (en) 2003-03-21 2003-04-03 Stephen Locarnini Therapeutic, prophylactic and diagnostic agents
AU2004229501B2 (en) 2003-04-11 2011-08-18 Medimmune, Llc Recombinant IL-9 antibodies and uses thereof
SE0301087D0 (sv) 2003-04-14 2003-04-14 Cartela Ab New monoclonal antibody
GB0309126D0 (en) 2003-04-17 2003-05-28 Neutec Pharma Plc Clostridium difficile focussed antibodies
US7619070B2 (en) 2003-04-23 2009-11-17 Medarex, Inc. Humanized antibodies to interferon alpha receptor-1 (IFNAR-1)
US8613922B2 (en) 2003-04-24 2013-12-24 The University Of North Carolina At Chapel Hill Methods for inhibiting diabetic retinopathy with an antibody against integrin associated protein (IAP)
GB2401040A (en) 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
WO2004096271A1 (en) 2003-04-30 2004-11-11 Uwe Zangemeister-Wittke Methods for treating cancer using an immunotoxin
JP2007535895A (ja) 2003-05-01 2007-12-13 イムクローン システムズ インコーポレイティド ヒトインシュリン様成長因子−１受容体に対する完全ヒト抗体
CR20120384A (es) 2003-05-14 2016-12-02 Immunogen Inc Composición de farmaco conjugado
GB0313259D0 (en) 2003-06-09 2003-07-16 Consejo Superior Investigacion Magnetic nanoparticles
US8071645B2 (en) 2003-06-12 2011-12-06 The Regents Of The University Of Colorado Systems and methods for treating human inflammatory and proliferative diseases and wounds, with fatty acid metabolism inhibitors and/or glycolytic inhibitors
EP1953223A1 (en) 2003-06-13 2008-08-06 Danisco A/S Variant pseudomonas polypeptides having a non-maltogenic exoamylase activity and their use in preparing food products
NZ544486A (en) 2003-06-13 2009-04-30 Biogen Idec Inc Aglycosyl anti-cd154 (cd40 ligand) antibodies and uses thereof
JPWO2005017155A1 (ja) 2003-06-18 2006-10-12 中外製薬株式会社 フコーストランスポーター
US7393534B2 (en) 2003-07-15 2008-07-01 Barros Research Institute Compositions and methods for immunotherapy of cancer and infectious diseases
GB0407315D0 (en) 2003-07-15 2004-05-05 Cambridge Antibody Tech Human antibody molecules
NZ544797A (en) 2003-07-18 2011-04-29 Amgen Fremont Inc Specific antibodies that bind HGF and neutralise binding of HGF to met
US20050106667A1 (en) 2003-08-01 2005-05-19 Genentech, Inc Binding polypeptides with restricted diversity sequences
US7871768B2 (en) 2003-08-04 2011-01-18 The Hospital For Sick Children Lafora's disease gene
EP1668111A4 (en) 2003-08-08 2008-07-02 Genenews Inc OSTEOARTHRITIS BIOMARKERS AND USES THEREOF
WO2005014818A1 (ja) 2003-08-08 2005-02-17 Perseus Proteomics Inc. 癌高発現遺伝子
US20050048617A1 (en) 2003-08-18 2005-03-03 Medimmune, Inc. Humanization of antibodies
US7589181B2 (en) 2003-08-29 2009-09-15 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Minimally immunogenic variants of SDR-grafted humanized antibody CC49 and their use
EP1514561A1 (en) 2003-09-10 2005-03-16 Philogen S.p.A. Targeting of tumor vasculature using radiolabelled antibody L19 against fibronectin ED-B
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
GB0321997D0 (en) 2003-09-19 2003-10-22 Novartis Ag Organic compound
EP1522594A3 (en) 2003-10-06 2005-06-22 Bayer HealthCare AG Methods and kits for investigating cancer
WO2005035753A1 (ja) 2003-10-10 2005-04-21 Chugai Seiyaku Kabushiki Kaisha 機能蛋白質を代替する二重特異性抗体
EP1693448A4 (en) 2003-10-14 2008-03-05 Chugai Pharmaceutical Co Ltd DOUBLE SPECIFICITY ANTIBODY FOR FUNCTIONAL PROTEIN SUBSTITUTION
JP5021309B2 (ja) 2003-10-16 2012-09-05 ステファン ジョン ラルフ 免疫調節性組成物およびその使用方法
NZ546873A (en) 2003-10-24 2010-09-30 Immunaid Pty Ltd Method of analysing immune system cycling to monitor and/or treat diseases characterised by the production of regulator T cells
CA2544365A1 (en) 2003-11-01 2005-05-12 Biovation, Ltd. Modified anti-cd52 antibody
WO2005047324A2 (en) 2003-11-10 2005-05-26 Schering Corp ANTI-INTERLEUKIN ANTIBODY-10
US7700737B2 (en) 2003-12-05 2010-04-20 Multimmune Gmbh Therapeutic and diagnostic anti-Hsp70 antibodies
CA2548813A1 (en) 2003-12-08 2005-06-23 Morphotek, Inc. Antibodies that specifically bind pms2
EP2135619A1 (en) 2003-12-10 2009-12-23 Millennium Pharmaceuticals, Inc. Humanized anti-CCR2 antibodies and methods of use therefor
CA2494572A1 (en) 2003-12-19 2005-06-19 Cytochroma Inc. Cytochrome p450 24 (cyp24) monoclonal antibody and methods and uses thereof
HUE049161T2 (hu) 2003-12-23 2020-09-28 Genentech Inc Új anti-IL13 antitestek és alkalmazásaik
EA011859B9 (ru) 2004-01-05 2013-07-30 Емд Лексиген Ресерч Сентер Корп. Соединения для адресной доставки препарата к ткани или органу-мишени
US7510710B2 (en) 2004-01-08 2009-03-31 The Regents Of The University Of Colorado Compositions of UCP inhibitors, Fas antibody, a fatty acid metabolism inhibitor and/or a glucose metabolism inhibitor
JP4987484B2 (ja) 2004-01-22 2012-07-25 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 補体結合が低下した抗癌抗体
CA2552351A1 (en) 2004-01-30 2005-09-09 Dana-Farber Cancer Institute, Inc. Method for determination and quantification of radiation or genotoxin exposure
RS51908B (en) 2004-02-06 2012-02-29 University Of Massachusetts CLOSTRIDIUM DIFFICILE TOXIN ANTIBODIES AND THEIR USES
PL1729795T3 (pl) 2004-02-09 2016-08-31 Human Genome Sciences Inc Białka fuzyjne albuminy
BRPI0506629A (pt) 2004-02-10 2007-05-02 Univ Colorado inibição do fator b, a via alternativa do sistema complemento e métodos relacionados
EP2340850A1 (en) 2004-02-10 2011-07-06 The Regents of the University of Colorado, a Body Corporate Inhibition of factor B, the alternative complement pathway and methods related thereto
US20050232919A1 (en) 2004-02-12 2005-10-20 Morphotek, Inc. Monoclonal antibodies that specifically block biological activity of a tumor antigen
WO2005080435A1 (ja) 2004-02-20 2005-09-01 Immuno-Biological Laboratories Co., Ltd. モノクローナル抗体およびその利用
ATE498010T1 (de) 2004-03-01 2011-02-15 Immune Disease Inst Inc Natürliche igm-antikörper und inhibitoren davon
EP1730196B1 (en) 2004-03-12 2010-12-22 Vasgene Therapeutics, Inc. Antibodies binding to ephb4 for inhibiting angiogenesis and tumor growth
PL1735348T3 (pl) 2004-03-19 2012-11-30 Imclone Llc Ludzkie przeciwciało przeciwko receptorowi naskórkowego czynnika wzrostu
EP1728801A4 (en) 2004-03-24 2009-10-21 Chugai Pharmaceutical Co Ltd SUBTYP OF A HUMANIZED ANTIBODY AGAINST THE INTERLEUKIN-6 RECEPTOR
EP1786463A4 (en) 2004-03-26 2009-05-20 Human Genome Sciences Inc ANTIBODY AGAINST NOGO RECEPTOR
RU2386638C2 (ru) 2004-03-31 2010-04-20 Дженентек, Инк. Гуманизированные анти-тфр-бета-антитела
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
BR122019013200B1 (pt) 2004-04-22 2022-04-12 Commonwealth Scientific And Industrial Research Organisation Polinucleotídeo isolado, vetor, célula microbiana recombinante capaz de sintetizar ácido (s) graxo(s) poliinsaturado(s) de cadeia longa, método para produção da referida célula microbiana recombinante, método para produção de ácido(s) graxo(s) poliinsaturado(s) de cadeia longa, método para produção de óleo, método para produção de semente oleaginosa, extrato de semente transgênica, composição, ração e uso da referida célula recombinante, vetor ou extrato
WO2005107801A2 (en) 2004-04-29 2005-11-17 The Regents Of The University Of Colorado Systems and methods for treating human inflammatory and proliferative diseases, with a combination of fatty acid metabolism inhibitors and glycolytic inhibitors and/or ucp and/or fas antibodies
GB0410627D0 (en) 2004-05-12 2004-06-16 Scancell Ltd Specific binding members
EP1761784B1 (en) 2004-05-24 2016-10-26 Universität Zu Köln Identification of ergothioneine transporter and therapeutic uses thereof
EP2330120A3 (en) 2004-06-02 2011-11-16 AdAlta Pty Ltd Binding moieties based on Shark IgNAR domains
US20090081243A1 (en) 2004-06-03 2009-03-26 Athlomics Pty Ltd. Agents and methods for diagnosing stress
EP1602926A1 (en) 2004-06-04 2005-12-07 University of Geneva Novel means and methods for the treatment of hearing loss and phantom hearing
WO2005123048A2 (en) 2004-06-21 2005-12-29 Proteome Sciences Plc Screening methods using c-abl, fyn and syk in combination with tau protein
RS52593B (en) 2004-06-24 2013-04-30 Biogen Idec Ma Inc. TREATMENT OF THE CONDITIONS CONCERNING DEMYELINIZATION
US7973134B2 (en) 2004-07-07 2011-07-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways
CN101072587B (zh) 2004-07-26 2012-12-26 比奥根艾迪克Ma公司 抗-cd154抗体
AR050044A1 (es) 2004-08-03 2006-09-20 Novartis Ag Anticuerpo especifico de il-4
US7846438B2 (en) 2004-08-03 2010-12-07 Biogen Idec Ma Inc. Methods of promoting neurite outgrowth with soluble TAJ polypeptides
CN101123994B (zh) 2004-08-16 2012-11-14 夸克医药公司 Rtp801的抑制剂的治疗性用途
CA2478458A1 (en) 2004-08-20 2006-02-20 Michael Panzara Treatment of pediatric multiple sclerosis
DK1784220T3 (en) 2004-08-26 2018-03-19 Univ Western Ontario BACTERIAL OBJECTIVES TO ACHIEVE IRON
TWI374935B (en) 2004-08-27 2012-10-21 Pfizer Ireland Pharmaceuticals Production of α-abeta
TWI384069B (zh) 2004-08-27 2013-02-01 Pfizer Ireland Pharmaceuticals 多胜肽之製法
US7300773B2 (en) 2004-08-27 2007-11-27 Wyeth Research Ireland Limited Production of TNFR-Ig
US20060045877A1 (en) 2004-08-30 2006-03-02 Goldmakher Viktor S Immunoconjugates targeting syndecan-1 expressing cells and use thereof
US7432359B2 (en) 2004-09-06 2008-10-07 Kirin Pharma Kabushiki Kaisha Anti-A33 antibody
KR100918746B1 (ko) 2004-09-06 2009-09-24 교와 핫꼬 기린 가부시키가이샤 항 ａ３３ 항체
EP1793850A4 (en) 2004-09-21 2010-06-30 Medimmune Inc ANTIBODIES TO THE METHOD AND METHOD FOR THE PRODUCTION OF VACCINES AGAINST THE RESPIRATORY SYNCYTIAL VIRUS
DK1804836T3 (da) 2004-09-24 2011-01-24 Beth Israel Hospital Fremgangsmåder til diagnosticering og behandling af graviditetskomplikationer
CA2582683A1 (en) 2004-10-01 2006-04-13 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Novel antibodies directed to the mammalian eag1 ion channel protein
US7935790B2 (en) 2004-10-04 2011-05-03 Cell Singaling Technology, Inc. Reagents for the detection of protein phosphorylation in T-cell receptor signaling pathways
KR101370253B1 (ko) 2004-10-22 2014-03-05 암젠 인크 재조합 항체의 재접힘 방법
EP2422811A2 (en) 2004-10-27 2012-02-29 MedImmune, LLC Modulation of antibody specificity by tailoring the affinity to cognate antigens
BRPI0517967B8 (pt) 2004-11-09 2021-05-25 Philogen Spa anticorpo isolado que liga-se a tenascina-c humana
CA2590671A1 (en) 2004-11-18 2006-05-26 Imclone Systems Incorporated Antibodies against vascular endothelial growth factor receptor-1
AU2005306399B2 (en) 2004-11-19 2012-02-09 Biogen Ma Inc. Treatment for multiple sclerosis
EP1812064A4 (en) 2004-11-19 2009-07-08 Cornell Res Foundation Inc USE OF ENDOTHELIAL VASCULAR GROWTH FACTOR RECEPTOR CELLS IN THE TREATMENT AND MONITORING OF CANCER AND IN THE SCREENING OF CHEMOTHERAPEUTIC AGENTS
GB0426146D0 (en) 2004-11-29 2004-12-29 Bioxell Spa Therapeutic peptides and method
US7517870B2 (en) 2004-12-03 2009-04-14 Fondazione Telethon Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization
EP2295465B1 (en) 2004-12-06 2013-02-13 Kyowa Hakko Kirin Co., Ltd. Human monoclonal antibodies to influenza M2 protein and methods of making and using same
CA2590180A1 (en) 2004-12-10 2006-06-15 The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland Binding partners of antibodies specific for dendritic cell antigens
EP1833964B1 (en) 2004-12-17 2013-05-22 Monash University Regulation of metalloprotease cleavage of cell surface proteins by adam10
US7807789B2 (en) 2004-12-21 2010-10-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in EGFR-signaling pathways
US20090061485A1 (en) 2004-12-22 2009-03-05 Chugai Seiyaku Kabushiki Kaisha Method of Producing an Antibody Using a Cell in Which the Function of Fucose Transporter Is Inhibited
EP2364995A1 (en) 2004-12-23 2011-09-14 Molmed SpA Conjugation product
KR20070082597A (ko) 2004-12-30 2007-08-21 에이전시 포 사이언스, 테크놀로지 앤드 리서치 유전자
EP2520669A3 (en) 2005-02-07 2013-02-27 GeneNews Inc. Mild osteoathritis biomarkers and uses thereof
HUE042689T2 (hu) 2005-02-08 2019-07-29 Genzyme Corp TGFbéta elleni antitestek
EP2468304A3 (en) 2005-02-11 2012-09-26 ImmunoGen, Inc. Process for preparing stable drug conjugates
WO2006088833A2 (en) 2005-02-14 2006-08-24 Wyeth Interleukin-17f antibodies and other il-17f signaling antagonists and uses therefor
CN101160528A (zh) 2005-02-14 2008-04-09 惠氏公司 Il17-f在诊断和治疗气道炎症中的用途
AU2006214121B9 (en) 2005-02-15 2013-02-14 Duke University Anti-CD19 antibodies and uses in oncology
US20090214543A1 (en) 2005-02-16 2009-08-27 University Of Zurich Methods for treating cancer using an immuno-toxin comprising an exotoxin a moiety having a furin cleavage site replaced with a cancer associated protease site cleaved by mmp-2 or mmp-9
WO2006089095A2 (en) 2005-02-17 2006-08-24 Biogen Idec Ma Inc. Treating neurological disorders
BRPI0608254A2 (pt) 2005-03-02 2009-12-08 Biogen Idec Inc anticorpos kim-1 para o tratamento de condições mediadas por th2
US8211430B2 (en) 2005-03-04 2012-07-03 Curedm Group Holdings, Llc Methods and pharmaceutical compositions for treating type 1 diabetes mellitus and other conditions
WO2006099141A2 (en) 2005-03-10 2006-09-21 Morphotek, Inc. Anti-mesothelin antibodies
EP1869192B1 (en) 2005-03-18 2016-01-20 MedImmune, LLC Framework-shuffling of antibodies
EP2526957A3 (en) 2005-03-30 2013-02-20 Minerva Biotechnologies Corporation Proliferation of MUC1 expressing cells
EP1863519B1 (en) 2005-03-31 2013-09-25 The General Hospital Corporation Modulating hgf/hgfr activity for treating lymphodema
WO2006106905A1 (ja) 2005-03-31 2006-10-12 Chugai Seiyaku Kabushiki Kaisha 会合制御によるポリペプチド製造方法
EP1872136B9 (en) 2005-04-04 2023-02-08 Biogen MA Inc. Methods and products for evaluating an immune response to a therapeutic protein
EP1876236B9 (en) 2005-04-08 2015-02-25 Chugai Seiyaku Kabushiki Kaisha Antibody substituting for function of blood coagulation factor viii
GT200600148A (es) 2005-04-14 2006-11-22 Metodos para el tratamiento y la prevencion de fibrosis
EP1868650B1 (en) 2005-04-15 2018-10-03 MacroGenics, Inc. Covalent diabodies and uses thereof
EP1874331B1 (en) 2005-04-19 2014-09-03 Kings College London Use of bip against bone loss and osteoporosis
CA2605507C (en) 2005-04-19 2016-06-28 Seattle Genetics, Inc. Humanized anti-cd70 binding agents and uses thereof
CA2607455A1 (en) 2005-04-22 2006-11-02 Morphotek, Inc. Antibodies with immune effector activity and that internalize in endosialin-positive cells
EP1879922A2 (en) 2005-04-22 2008-01-23 Morphotek, Inc. Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells
WO2006118821A2 (en) 2005-05-02 2006-11-09 The Regents Of The University Of Colorado Systems and methods for treating human inflammatory and proliferative diseases, with a combination of compounds, or a bifunctional compound,that provides fatty acid metabolism and glycolysis inhibition
EP2221316A1 (en) 2005-05-05 2010-08-25 Duke University Anti-CD19 antibody therapy for autoimmune disease
CN101198624B (zh) 2005-05-06 2012-10-10 津莫吉尼蒂克斯公司 Il-31单克隆抗体及使用方法
US7964200B2 (en) 2005-05-18 2011-06-21 Children's Hospital & Research Center At Oakland Methods and compositions for immunizing against Chlamydia infection
EP1883417A2 (en) 2005-05-25 2008-02-06 Curedm Inc. Peptides, derivatives and analogs thereof, and methods of using same
AU2006249835B2 (en) 2005-05-26 2011-09-08 Musc Foundation For Research Development Inhibition of the alternative complement pathway for treatment of traumatic brain injury, spinal cord injury and related conditions
CA2610987C (en) 2005-06-10 2013-09-10 Chugai Seiyaku Kabushiki Kaisha Stabilizer for protein preparation comprising meglumine and use thereof
EP1899376A2 (en) 2005-06-16 2008-03-19 The Feinstein Institute for Medical Research Antibodies against hmgb1 and fragments thereof
KR20080047529A (ko) 2005-06-17 2008-05-29 임클론 시스템즈 인코포레이티드 전이성 골암 치료를 위한 수용체 길항제
CA2613512A1 (en) 2005-06-23 2007-01-04 Medimmune, Inc. Antibody formulations having optimized aggregation and fragmentation profiles
CN103172738A (zh) 2005-06-30 2013-06-26 Abbvie公司 Il-12/p40结合蛋白
EP1910565A4 (en) 2005-07-07 2009-10-28 Athlomics Pty Ltd POLYNUCLEOTIDE MARKER GENES AND THEIR EXPRESSION IN THE DIAGNOSIS OF ENDOTOXEMIA
EP2394661A1 (en) 2005-07-08 2011-12-14 Biogen Idec MA Inc. Sp35 antibodies and uses thereof
EP1904652A2 (en) 2005-07-08 2008-04-02 Brystol-Myers Squibb Company Single nucleotide polymorphisms associated with dose-dependent edema and methods of use thereof
CN104072614B (zh) 2005-07-08 2017-04-26 生物基因Ma公司 抗-αvβ6 抗体及其用途
NZ599176A (en) 2005-08-03 2014-04-30 Immunogen Inc Immunoconjugate formulations
ES2526811T3 (es) 2005-08-10 2015-01-15 Macrogenics, Inc. Identificación y modificación de anticuerpos con regiones Fc variantes y métodos de uso de estos
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
EP2500354A3 (en) 2005-08-19 2012-10-24 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
WO2007024715A2 (en) 2005-08-19 2007-03-01 Abbott Laboratories Dual variable domain immunoglobin and uses thereof
SI1928503T1 (sl) 2005-08-24 2012-11-30 Immunogen Inc Postopek za pripravo konjugatov majtansinoid protitelo
CA2621083C (en) 2005-08-30 2017-04-11 University Of Miami Immunomodulating tumor necrosis factor receptor 25 (tnfr25) agonists, antagonists and immunotoxins
ME02705B (me) 2005-08-31 2017-10-20 Merck Sharp & Dohme Inženjerisana anti-il-23 antitela
WO2007027906A2 (en) 2005-08-31 2007-03-08 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in leukemia signaling pathways
RU2396275C2 (ru) 2005-09-29 2010-08-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Молекула адгезии т-клеток и антитело, направленное против молекулы
CA2624562A1 (en) 2005-09-30 2007-04-12 Abbott Gmbh & Co. Kg Binding domains of proteins of the repulsive guidance molecule (rgm) protein family and functional fragments thereof, and their use
ES2403733T3 (es) 2005-10-05 2013-05-21 Commonwealth Scientific And Industrial Research Organisation Proteínas de seda
GB0520568D0 (en) 2005-10-10 2005-11-16 Paradigm Therapeutics Ltd Receptor
UA92504C2 (en) 2005-10-12 2010-11-10 Эли Лилли Энд Компани Anti-myostatin monoclonal antibody
JP5014143B2 (ja) 2005-10-14 2012-08-29 学校法人福岡大学 膵島移植における移植膵島障害抑制剤
AR058135A1 (es) 2005-10-21 2008-01-23 Chugai Pharmaceutical Co Ltd Agentes para el tratamiento de cardiopatias
EP2319941A3 (en) 2005-10-21 2011-08-17 GeneNews Inc. Method and apparatus for correlating levels of biomarker products with disease
KR20080068048A (ko) 2005-10-28 2008-07-22 메이지 세이카 가부시키가이샤 녹농균의 외막 단백질 ｐａ5158
WO2007055902A1 (en) 2005-11-03 2007-05-18 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Immunogenic peptides and methods of use for treating and preventing cancer
WO2007056227A2 (en) 2005-11-04 2007-05-18 Genentech, Inc. Use of complement pathway inhibitors to treat ocular diseases
US20090246189A1 (en) 2005-11-04 2009-10-01 Biogen Idec Ma Inc. And Mclean Hospital Methods for Promoting Neurite Outgrowth and Survival of Dopaminergic Neurons
BRPI0618338A2 (pt) 2005-11-07 2011-08-23 Scripps Resarch Inst uso de inibidor de sinalização de fator tecidual, método para identificar um agente que inibe a sinalização de tf/viia, composições farmacêuticas e kit
UA96139C2 (uk) 2005-11-08 2011-10-10 Дженентек, Інк. Антитіло до нейропіліну-1 (nrp1)
US8128934B2 (en) 2005-11-14 2012-03-06 Ribomic, Inc. Method for treatment or prevention of disease associated with functional disorder of regulatory T cell
AR057582A1 (es) 2005-11-15 2007-12-05 Nat Hospital Organization Agentes para suprimir la induccion de linfocitos t citotoxicos
TWI461436B (zh) 2005-11-25 2014-11-21 Kyowa Hakko Kirin Co Ltd 人類ｃｄ１３４（ｏｘ４０）之人類單株抗體及其製造及使用方法
EP1967209B1 (en) 2005-11-25 2012-06-06 Keio University Therapeutic agent for prostate cancer
CA2631195C (en) 2005-11-30 2016-04-05 Abbott Laboratories Monoclonal antibodies against amyloid beta protein and uses thereof
CN101432302A (zh) 2005-11-30 2009-05-13 艾博特公司 抗－Aβ球聚体抗体，其抗原结合部分，相应的杂交瘤、核酸、载体、宿主细胞，生产所述抗体的方法，包含所述抗体的组合物，所述抗体的应用以及使用所述抗体的方法
EP2543384A3 (en) 2005-12-02 2013-04-10 Biogen Idec MA Inc. Treatment of conditions involving demyelination
CN101326195B9 (zh) 2005-12-13 2022-11-11 伊莱利利公司 抗il-17抗体
GB0525662D0 (en) 2005-12-16 2006-01-25 Glaxo Group Ltd Immunoglobulins
WO2007074880A1 (ja) 2005-12-28 2007-07-05 Chugai Seiyaku Kabushiki Kaisha 抗体含有安定化製剤
EP1981538B1 (en) 2005-12-30 2014-09-17 Dyax Corporation Metalloproteinase binding proteins
DK1966245T3 (da) 2005-12-30 2011-07-18 Merck Patent Gmbh Anti-CD19-Antistoffer med reduceret immunogenicitet
ES2350269T3 (es) 2006-01-18 2011-01-20 The General Hospital Corporation Métodos de aumento de la función linfática.
DOP2007000015A (es) 2006-01-20 2007-08-31 Quark Biotech Inc Usos terapéuticos de inhibidores de rtp801
US8771686B2 (en) 2006-01-27 2014-07-08 Chugai Seiyaku Kabushiki Kaisha Methods for treating a disease involving choroidal neovascularization by administering an IL-6 receptor antibody
BRPI0707276B1 (pt) 2006-01-27 2021-08-31 Biogen Ma Inc Polipeptídeo de fusão antagonista de receptor nogo
TWI417301B (zh) 2006-02-21 2013-12-01 Wyeth Corp 對抗人類介白素-２２（ｉｌ-２２）之抗體及其用途
TW200744634A (en) 2006-02-21 2007-12-16 Wyeth Corp Methods of using antibodies against human IL-22
US7820174B2 (en) 2006-02-24 2010-10-26 The United States Of America As Represented By The Department Of Health And Human Services T cell receptors and related materials and methods of use
EP2514823B1 (en) 2006-03-03 2018-05-02 ProMIS Neurosciences Inc. Methods and compositions to treat and detect misfolded-SOD1 mediated diseases
EP1999148B8 (en) 2006-03-06 2014-03-05 Medlmmune, LLC Humanized anti-cd22 antibodies and their use in treatment of oncology, transplantation and autoimmune disease
WO2007106769A2 (en) 2006-03-10 2007-09-20 Zymogenetics, Inc. Antibodies that bind both il-17a and il-17f and methods of using the same
BR122017024057B8 (pt) 2006-03-15 2021-05-25 Alexion Pharma Inc anticorpo que se liga à c5 e composição farmacêutica compreendendo dito anticorpo e um veículo farmaceuticamente aceitável
WO2007108152A1 (ja) 2006-03-23 2007-09-27 Tohoku University 高機能性二重特異性抗体
ES2424467T3 (es) 2006-03-27 2013-10-02 Medimmune Limited Miembro de unión para el receptor GM-CSF
SG170804A1 (en) 2006-03-30 2011-05-30 Meiji Seika Kaisha Pseudomonas aeruginosa outer membrane protein pa0427
EP4218801A3 (en) 2006-03-31 2023-08-23 Chugai Seiyaku Kabushiki Kaisha Antibody modification method for purifying bispecific antibody
US11046784B2 (en) 2006-03-31 2021-06-29 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
JP5754875B2 (ja) 2006-04-07 2015-07-29 国立大学法人大阪大学 筋再生促進剤
US8293245B2 (en) 2006-04-20 2012-10-23 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Methods and compositions based on Shiga toxin type 1 protein
CA2652349A1 (en) 2006-05-15 2007-11-22 University Of Kentucky Research Foundation Toll-like receptor (tlr) stimulation for ocular angiogenesis and macular degeneration
DK2034830T3 (da) 2006-05-25 2014-10-27 Biogen Idec Inc Anti-vla-1-antistof til behandling af slagtilfælde
US9217749B2 (en) 2006-05-31 2015-12-22 Lpath, Inc. Immune-derived moieties reactive against lysophosphatidic acid
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
US9274129B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Methods and reagents for detecting bioactive lipids
BRPI0711229A2 (pt) 2006-05-31 2013-01-08 Astellas Pharma Inc anticorpo humanizado da osteopontina anti-humana, polinucleotÍdeo, vetor de expressço, cÉlula hospedeita, mÉtodo para produzir um anticorpo humanizado de osteopontina anti-humana, fÁrmaco terapÊutico, mÉtodo para prevenir ou tratar doenÇa autoimune e uso do anticorpo humanizado de oesteopontina anti-humana
US8796429B2 (en) 2006-05-31 2014-08-05 Lpath, Inc. Bioactive lipid derivatives, and methods of making and using same
US9274130B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Prevention and treatment of pain using antibodies to lysophosphatidic acid
CN103272232B (zh) 2006-06-08 2018-07-24 中外制药株式会社 炎性疾病的预防或治疗药
AT503690A1 (de) 2006-06-09 2007-12-15 Biomay Ag Hypoallergene moleküle
AU2007260687B2 (en) 2006-06-14 2013-12-12 Provention Bio, Inc. Methods for the treatment of autoimmune disorders using monoclonal antibodies with reduced toxicity
WO2007147122A2 (en) 2006-06-15 2007-12-21 The Board Of Trustees Of The University Of Arkansas Monoclonal antibodies that selectively recognize methamphetamine and methamphetamine like compounds
CA2656224C (en) 2006-06-26 2018-01-09 Macrogenics, Inc. Combination of fc.gamma.riib antibodies and cd20-specific antibodies and methods of use thereof
PL2029173T3 (pl) 2006-06-26 2017-04-28 Macrogenics, Inc. Przeciwciała swoiste dla FC RIIB i sposoby ich zastosowania
US7572618B2 (en) 2006-06-30 2009-08-11 Bristol-Myers Squibb Company Polynucleotides encoding novel PCSK9 variants
EP2287189A1 (en) 2006-07-07 2011-02-23 Intercell AG Small Streptococcus pyogenes antigens and their use
AU2007272995B2 (en) 2006-07-10 2013-02-07 Biogen Idec Ma Inc. Compositions and methods for inhibiting growth of smad4-deficient cancers
EP2046959B1 (en) 2006-07-12 2015-11-18 Commonwealth Scientific and Industrial Research Organisation Wheat and barley with enhanced salinity tolerance
PT2495307T (pt) 2006-07-13 2018-05-10 Wyeth Llc Produção do fator ix de coagulação com padrão melhorado de glicosilação
JPWO2008007755A1 (ja) 2006-07-13 2009-12-10 中外製薬株式会社 細胞死誘導剤
ES2673822T3 (es) 2006-07-18 2018-06-25 Sanofi Anticuerpo antagonista contra EphA2 para el tratamiento de cáncer
EP2574625B1 (en) 2006-07-21 2015-02-25 HuBit genomix, Inc. Remedy for renal disease
MY150687A (en) 2006-07-21 2014-02-28 Femalon S P R L Assay and kit for predicting implantation success in assisted fertilisation
US7939636B2 (en) 2006-08-11 2011-05-10 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in c-Src signaling pathways
US9415111B2 (en) 2006-08-11 2016-08-16 Rutgers, The State University Of New Jersey Dual-sensitizer-containing luminescent compounds, conjugates, and uses thereof
EP3111955B1 (en) 2006-08-14 2019-01-23 Chugai Seiyaku Kabushiki Kaisha Diagnosis and treatment of cancer using anti-desmoglein-3 antibody
EA021255B1 (ru) 2006-08-28 2015-05-29 Киова Хакко Кирин Ко., Лимитед Антагонистические моноклональные антитела человека, специфичные в отношении light человека
CA2660175C (en) 2006-09-01 2015-05-12 Zymogenetics, Inc. Variable region sequences of il-31 monoclonal antibodies and methods of use
KR101503540B1 (ko) 2006-09-05 2015-03-17 알렉시온 파마슈티칼스, 인코포레이티드 항체 매개된 신경병증의 치료를 위한 방법과 조성물
GB0617429D0 (en) 2006-09-05 2006-10-18 Electrophoretics Ltd Markers of renal transplant rejection and renal damage
KR101544108B1 (ko) 2006-09-08 2015-08-13 애브비 바하마스 리미티드 인터루킨-13 결합 단백질
EP2500415A1 (en) 2006-09-13 2012-09-19 Abbott Laboratories Cell culture improvements
SG10201510384UA (en) 2006-09-13 2016-01-28 Abbvie Inc Cell culture improvements
WO2008039818A2 (en) 2006-09-26 2008-04-03 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Modified t cell receptors and related materials and methods
AU2007308145A1 (en) 2006-10-12 2008-04-17 Wyeth Modification of ionic strength in antibody-solutions to reduce opalescence/aggregates
CA2665528C (en) 2006-10-12 2018-01-23 The University Of Tokyo Diagnosis and treatment of cancer using anti-ereg antibody
EP2064335A4 (en) 2006-10-16 2011-03-30 Medimmune Llc MOLECULES WITH REDUCED HALF TIME, COMPOSITIONS AND ITS USE
EP1914242A1 (en) 2006-10-19 2008-04-23 Sanofi-Aventis Novel anti-CD38 antibodies for the treatment of cancer
CN101588816B (zh) 2006-10-19 2013-06-19 Csl有限公司 白介素-13受体α1的高亲和性抗体拮抗物
JP5378795B2 (ja) 2006-10-20 2013-12-25 中外製薬株式会社 抗ｈｂ−ｅｇｆ抗体を有効成分として含む医薬組成物
EP2093237B1 (en) 2006-10-20 2015-12-30 Chugai Seiyaku Kabushiki Kaisha Anti-cancer agent comprising anti-hb-egf antibody as active ingredient
SI2087002T1 (sl) * 2006-10-27 2014-11-28 Lpath, Inc. Sestavki in postopki za vezavo sfingozin-1-fosfata
US8614103B2 (en) 2006-10-27 2013-12-24 Lpath, Inc. Compositions and methods for treating sphingosine-1-phosphate (S1P) related ocular diseases and conditions
CU23636A1 (es) 2006-11-01 2011-03-21 Ct Ingenieria Genetica Biotech Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf)
PL2907827T3 (pl) 2006-11-02 2019-03-29 Genentech, Inc. Humanizowane przeciwciała przeciw czynnikowi D i ich zastosowanie
JP5401319B2 (ja) 2006-11-03 2014-01-29 ワイス・エルエルシー 細胞培養における解糖阻害物質
JP5570218B2 (ja) 2006-11-03 2014-08-13 ユースリー ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｆｇｆｒ４抗体
EP2089029B1 (en) 2006-11-10 2012-10-03 Massachusetts Institute of Technology Pak inhibitors for use in treating neurodevelopmental disorders
ES2437110T3 (es) 2006-11-14 2014-01-08 Genentech, Inc. Moduladores de la regeneración neuronal
JP5647414B2 (ja) 2006-11-17 2014-12-24 ノバルティス アーゲー Ｌｉｎｇｏ結合分子およびその医薬用使用
US20100047247A1 (en) 2006-11-17 2010-02-25 The Research Foundation For Microbial Diseases Of Osaka University Nerve elongation promoter and elongation inhibitor
EP1923069A1 (en) 2006-11-20 2008-05-21 Intercell AG Peptides protective against S. pneumoniae and compositions, methods and uses relating thereto
US8785400B2 (en) 2006-11-22 2014-07-22 Curedm Group Holdings, Llc Methods and compositions relating to islet cell neogenesis
US20080199475A1 (en) 2006-11-27 2008-08-21 Patrys Limited Novel glycosylated peptide target in neoplastic cells
TW200831528A (en) 2006-11-30 2008-08-01 Astrazeneca Ab Compounds
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
ES2523915T5 (es) 2006-12-01 2022-05-26 Seagen Inc Agentes de unión a la diana variantes y usos de los mismos
US8288110B2 (en) 2006-12-04 2012-10-16 Perkinelmer Health Sciences, Inc. Biomarkers for detecting cancer
EP2687232A1 (en) 2006-12-06 2014-01-22 MedImmune, LLC Methods of treating systemic lupus erythematosus
EP2102366A4 (en) 2006-12-10 2010-01-27 Dyadic International Inc EXPRESSION AND HIGH-DROP SCREENING OF COMPLEX EXPRESSED DNA LIBRARIES IN FADENED MUSHROOMS
BRPI0720271A2 (pt) 2006-12-14 2014-01-28 Schering Corp Anticorpo anti-tslp projetado
CA2672581A1 (en) 2006-12-14 2008-06-19 Forerunner Pharma Research Co., Ltd. Anti-claudin 3 monoclonal antibody and treatment and diagnosis of cancer using the same
WO2008076960A2 (en) 2006-12-18 2008-06-26 Genentech, Inc. Antagonist anti-notch3 antibodies and their use in the prevention and treatment of notch3-related diseases
DE102006062398A1 (de) 2006-12-20 2008-06-26 Edi (Experimentelle & Diagnostische Immunologie) Gmbh Verfahren zur Erkennung und/oder Charakterisierung zellulärer Aktivitätsmuster, Verwendung von Toll-like-Rezeptor-Liganden (TLR-Liganden) und ein Kit
ES2533566T3 (es) 2006-12-29 2015-04-13 The Regents Of The University Of Colorado, A Body Corporate Diana diagnóstica y terapéutica para enfermedades autoinmunitarias y sus usos
US20100111851A1 (en) 2007-01-05 2010-05-06 The University Of Tokyo Diagnosis and treatment of cancer by using anti-prg-3 antibody
PT2099826E (pt) 2007-01-05 2014-01-09 Univ Zuerich Anticorpo anti-beta-amilóide e suas utilizações
US8128926B2 (en) 2007-01-09 2012-03-06 Biogen Idec Ma Inc. Sp35 antibodies and uses thereof
JP2010515456A (ja) 2007-01-09 2010-05-13 バイオジェン・アイデック・エムエイ・インコーポレイテッド Ｓｐ３５抗体およびその使用
US8642295B2 (en) 2007-01-11 2014-02-04 Erasmus University Medical Center Circular chromosome conformation capture (4C)
EP2266592A3 (en) 2007-01-12 2012-08-08 Intercell AG Protective proteins of S. agalactiae, combinations thereof and methods of using the same
AU2008206442B2 (en) 2007-01-12 2012-10-18 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services gp100-specific T cell receptors and related materials and methods of use
TWI438208B (zh) 2007-01-23 2014-05-21 Chugai Pharmaceutical Co Ltd 抑制慢性排斥反應之藥劑
WO2008093688A1 (ja) 2007-01-30 2008-08-07 Forerunner Pharma Research Co., Ltd. キメラFcγレセプター及び該レセプターを用いたＡＤＣＣ活性測定方法
US8168415B2 (en) 2007-02-07 2012-05-01 The Regents Of The University Of Colorado Axl fusion proteins as Axl tyrosine kinase inhibitors
EP1958645A1 (en) 2007-02-13 2008-08-20 Biomay AG Peptides derived from the major allergen of ragweed (Ambrosia artemisiifolia) and uses thereof
US7883705B2 (en) 2007-02-14 2011-02-08 Kyowa Hakko Kirin Co., Ltd. Anti FGF23 antibody and a pharmaceutical composition comprising the same
AR065368A1 (es) 2007-02-15 2009-06-03 Astrazeneca Ab Anticuerpos para moleculas de ige
PT2130044T (pt) 2007-02-16 2017-02-03 Genzyme Corp Método para a identificação de risco de distúrbio da tiróide
US8114606B2 (en) 2007-02-16 2012-02-14 The Board Of Trustees Of Southern Illinois University ARL-1 specific antibodies
US8685666B2 (en) 2007-02-16 2014-04-01 The Board Of Trustees Of Southern Illinois University ARL-1 specific antibodies and uses thereof
US9023352B2 (en) 2007-02-20 2015-05-05 Tufts University Methods, compositions and kits for treating a subject using a recombinant heteromultimeric neutralizing binding protein
EP2426145B1 (en) 2007-02-23 2017-01-18 Merck Sharp & Dohme Corp. Engineered anti-il-23p19 antibodies
AR065420A1 (es) 2007-02-23 2009-06-03 Schering Corp Anticuerpos anti-il-23 p19 de ingenieria
EP2124952A2 (en) 2007-02-27 2009-12-02 Abbott GmbH & Co. KG Method for the treatment of amyloidoses
CN101951953A (zh) 2007-02-27 2011-01-19 株式会社未来创药研究所 含抗grp78抗体作为有效成分的药物组合物
CN101675076B (zh) 2007-02-28 2013-09-18 默沙东公司 工程化的抗il-23r抗体
US9012180B2 (en) 2007-03-02 2015-04-21 Wyeth Llc Use of copper and glutamate in cell culture for production of polypeptides
US20090081659A1 (en) 2007-03-07 2009-03-26 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
CL2008000719A1 (es) 2007-03-12 2008-09-05 Univ Tokushima Chugai Seiyaku Agente terapeutico para cancer resistente a agentes quimioterapeuticos que comprende un anticuerpo que reconoce hla de clase i como ingrediente activo; composicion farmaceutica que comprende dicho anticuerpo; y metodo para tratar cancer resistente a
CA2680914C (en) 2007-03-13 2019-06-18 University Of Zurich Monoclonal human tumor-specific antibody
BRPI0809042B1 (pt) 2007-03-22 2021-08-31 Biogen Ma Inc. Proteína de ligação a cd154 isolada, seu uso, e composição
EP3926045A1 (en) 2007-03-22 2021-12-22 Heptares Therapeutics Limited Mutant proteins and methods for selecting them
US20090068684A1 (en) 2007-03-26 2009-03-12 Cell Signaling Technology, Inc. Serine and threoninephosphorylation sites
JP5456658B2 (ja) 2007-03-30 2014-04-02 メディミューン，エルエルシー 抗体製剤
ES2402171T3 (es) 2007-04-02 2013-04-29 Philogen S.P.A. El antígeno ED-A del fibrinógeno está asociado con la neovasculatura de las metástasis tumorales
ES2452929T3 (es) 2007-04-05 2014-04-03 Morphotek, Inc. Métodos para inhibir la unión de endosialina a ligandos
HUE027593T2 (en) 2007-04-12 2016-11-28 Brigham & Womens Hospital Inc ABCB5 targeting cancer therapy
US7977462B2 (en) 2007-04-19 2011-07-12 Cell Signaling Technology, Inc. Tyrosine phosphorylation sites
EP1983003A3 (en) 2007-04-19 2009-03-11 Peter Hornbeck Tyrosine phosphorylation sites and antibodies specific for them
EP2145902A3 (en) 2007-04-19 2010-09-29 Peter Hornbeck Tyrosine phosphorylation sites and antibodies specific for them
EP2140263B1 (en) 2007-04-20 2017-01-04 The Board of Trustees of The University of Arkansas Hapten compounds and compositions and uses thereof
TW200902708A (en) 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
WO2008132516A1 (en) 2007-04-26 2008-11-06 Opsona Therapeutics Limited Toll-like receptor binding epitope and compositions for binding thereto
WO2008134659A2 (en) 2007-04-27 2008-11-06 Zymogenetics, Inc. Antagonists to il-17a, il-17f, and il-23p19 and methods of use
US20090053831A1 (en) 2007-05-01 2009-02-26 Cell Signaling Technology, Inc. Tyrosine phosphorylation sites
CA2685805A1 (en) 2007-05-02 2008-11-13 Intercell Ag Klebsiella antigens
EP2164868B1 (en) 2007-05-04 2015-03-25 Technophage, Investigação E Desenvolvimento Em Biotecnologia, SA Engineered rabbit antibody variable domains and uses thereof
US20080279851A1 (en) 2007-05-07 2008-11-13 Medlmmune, Llc Anti-icos antibodies and their use in treatment of oncology, transplantation and autoimmune disease
WO2008143797A1 (en) 2007-05-11 2008-11-27 Genzyme Corporation Methods of producing a secreted protein
ES2558689T3 (es) 2007-05-14 2016-02-08 Medimmune, Llc Métodos para reducir los niveles de eosinófilos
JP5117765B2 (ja) 2007-05-28 2013-01-16 国立大学法人 東京大学 抗ｒｏｂｏ１抗体を含むｐｅｔ用腫瘍診断剤
US9163091B2 (en) 2007-05-30 2015-10-20 Lpath, Inc. Compositions and methods for binding lysophosphatidic acid
AU2008260135A1 (en) 2007-05-30 2008-12-11 Lpath, Inc. Compositions and methods for binding lysophosphatidic acid
US8604172B2 (en) 2009-04-17 2013-12-10 Lpath, Inc. Humanized antibody compositions and methods for binding lysophosphatidic acid
WO2008144827A1 (en) 2007-05-31 2008-12-04 The University Of Queensland Diagnostic markers for ankylosing spondylitis and uses thereof
WO2008154251A2 (en) 2007-06-07 2008-12-18 Genentech, Inc. C3b antibodies and methods for the prevention and treatment of complement- associated disorders
KR100883430B1 (ko) 2007-06-13 2009-02-12 한국생명공학연구원 혈관내피성장인자 수용체를 중화하는 인간 단클론항체 및그 용도
CN101778640A (zh) 2007-06-14 2010-07-14 比奥根艾迪克Ma公司 抗体制剂
EP2167530A2 (en) 2007-06-18 2010-03-31 Intercell AG Chlamydia antigens
US8252897B2 (en) 2007-06-21 2012-08-28 Angelica Therapeutics, Inc. Modified toxins
CA2691434C (en) 2007-06-21 2020-07-21 Macrogenics, Inc. Covalent diabodies and uses thereof
US8263072B2 (en) 2007-06-22 2012-09-11 Genera Istrazivanja, d.o.o. ADAMTS4 as a blood biomarker and therapeutic target for chronic renal failure
WO2009001840A1 (ja) 2007-06-25 2008-12-31 Forerunner Pharma Research Co., Ltd. ADCC活性又はCDC活性を有する抗Prominin-1抗体
AU2008278702B2 (en) 2007-07-25 2014-07-31 Philogen S.P.A. The ED-A antigen of fibrinogen is associated with the neovas culature of tumor metastases
WO2009014263A1 (ja) 2007-07-26 2009-01-29 Osaka University インターロイキン６受容体阻害剤を有効成分とする眼炎症疾患治療剤
JP5659014B2 (ja) 2007-08-02 2015-01-28 ジリード バイオロジクス，インク． 線維症、腫瘍浸潤、血管新生及び転移の治療及び診断のための方法及び組成物
CN101848724A (zh) 2007-08-03 2010-09-29 奥普索纳医疗有限公司 Trl-2拮抗剂在治疗再灌注损伤和组织损伤中的用途
JP5749009B2 (ja) 2007-08-13 2015-07-15 バスジーン セラピューティクス，インコーポレイテッドＶａｓｇｅｎｅｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ＥｐｈＢ４に結合するヒト化抗体を利用する癌治療剤
NZ583605A (en) 2007-08-29 2012-10-26 Sanofi Aventis Humanized anti-cxcr5 antibodies, derivatives thereof and their uses
KR20100080519A (ko) 2007-08-30 2010-07-08 큐어디엠 인코포레이티드 프로섬 펩타이드 및 이의 유사체의 조성물 및 이의 이용 방법
EP2197893B1 (en) 2007-09-07 2013-07-24 Dyadic International, Inc. Novel fungal enzymes
EP2527369A3 (en) 2007-09-13 2012-12-19 University Of Zurich Prorektorat Forschung Monoclonal amyloid beta (abeta)-specific antibody and uses thereof
US20100226925A1 (en) 2007-09-14 2010-09-09 Amgen Inc. Homogeneous Antibody Populations
US20090136427A1 (en) 2007-09-18 2009-05-28 La Jolla Institute For Allergy And Immunology LIGHT Inhibitors For Asthma, Lung and Airway Inflammation, Respiratory, Interstitial, Pulmonary and Fibrotic Disease Treatment
SI2202245T1 (sl) 2007-09-26 2016-10-28 Chugai Seiyaku Kabushiki Kaisha Postopek modificiranja izoelektrične točke protitelesa preko aminokislinske substitucije v CDR
GB0718843D0 (en) * 2007-09-26 2007-11-07 Cancer Rec Tech Ltd Materials and methods relating to modifying the binding of antibodies
AR066172A1 (es) 2007-09-28 2009-07-29 Chugai Pharmaceutical Co Ltd Metodo para la preparacion de un anticuerpo antiglipicano 3 con modulada cinetica plasmatica mediante variacion de la semivida plasmatica.
EP2203747B1 (en) 2007-09-28 2016-11-30 Welcome Receptor Antibodies PTY LTD Anti-calcitonin antibody
CN101815532B (zh) 2007-10-02 2012-08-15 中外制药株式会社 以白细胞介素6受体抑制剂为有效成分的移植物抗宿主病治疗剂
US8470560B2 (en) 2007-10-03 2013-06-25 The United States Of America As Represented By The Secretary Of The Army CR-2 binding peptide P28 as molecular adjuvant for DNA vaccines
EP2050764A1 (en) 2007-10-15 2009-04-22 sanofi-aventis Novel polyvalent bispecific antibody format and uses thereof
KR101558009B1 (ko) 2007-10-15 2015-10-19 추가이 세이야쿠 가부시키가이샤 항체의 제조 방법
US8361465B2 (en) 2007-10-26 2013-01-29 Lpath, Inc. Use of anti-sphingosine-1-phosphate antibodies in combination with chemotherapeutic agents
US8222377B2 (en) 2007-10-30 2012-07-17 Philogen, S.P.A. Antigen associated with rheumatoid arthritis
NZ584911A (en) 2007-11-02 2011-08-26 Novartis Ag Improved nogo-a binding molecules and pharmaceutical use thereof
EP2219452B1 (en) 2007-11-05 2015-10-14 MedImmune, LLC Methods of treating scleroderma
JP5710978B2 (ja) 2007-11-08 2015-04-30 ネオジェニックス オンコロジー， インコーポレイテッド 結腸癌および膵臓癌に対する組み換えモノクローナル抗体および対応抗原
MX2010005115A (es) 2007-11-08 2010-05-27 Genentech Inc Anticuerpos anti-factor b y sus usos.
US8415361B2 (en) 2007-11-09 2013-04-09 The Salk Institute For Biological Studies Use of TAM receptor inhibitors as antimicrobials
DK2220121T3 (en) 2007-11-12 2015-12-07 U3 Pharma Gmbh AXL antibodies
WO2009063970A1 (ja) 2007-11-14 2009-05-22 Forerunner Pharma Research Co., Ltd. 抗gpr49抗体を用いる癌の診断および治療
SG188134A1 (en) 2007-11-15 2013-03-28 Chugai Pharmaceutical Co Ltd Monoclonal antibody capable of binding to anexelekto, and use thereof
US20090203043A1 (en) 2007-11-21 2009-08-13 Peter Hornbeck Protein phosphorylation by basophilic serine/threonine kinases in insulin signaling pathways
BRPI0819774A2 (pt) 2007-11-28 2014-10-14 Univ Pennsylvania Subfamília c de adenovírus sadv-40, -31 e -34 de símio e seus usos
JP5490714B2 (ja) 2007-11-28 2014-05-14 メディミューン，エルエルシー タンパク質製剤
DK2220241T3 (en) 2007-11-28 2017-01-09 Univ Pennsylvania Adenovirus comprising a simian adenovirus E-SAdV-39-capsidhexonprotein and uses thereof
WO2009079242A2 (en) 2007-12-05 2009-06-25 Massachusetts Institute Of Technology Aglycosylated immunoglobulin mutants
EP2241332A4 (en) 2007-12-05 2011-01-26 Chugai Pharmaceutical Co Ltd THERAPEUTIC AGENT AGAINST PRITURE
KR101643005B1 (ko) 2007-12-05 2016-07-28 추가이 세이야쿠 가부시키가이샤 항ｎｒ１０ 항체 및 그의 이용
EA020457B1 (ru) 2007-12-07 2014-11-28 Займоджинетикс, Инк. Молекулы гуманизированных антител, специфичных к il-31
GB0724051D0 (en) 2007-12-08 2008-01-16 Medical Res Council Mutant proteins and methods for producing them
US20110262425A1 (en) 2007-12-12 2011-10-27 National Cancer Center Therapeutic agent for mll leukemia and moz leukemia of which molecular target is m-csf receptor, and use thereof
GB0724860D0 (en) 2007-12-20 2008-01-30 Heptares Therapeutics Ltd Screening
US8092804B2 (en) 2007-12-21 2012-01-10 Medimmune Limited Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
KR101759457B1 (ko) 2007-12-21 2017-07-31 메디뮨 리미티드 인터루킨-4 수용체 알파(ＩＬ-4Ｒα)에 대한 결합 구성원-173
KR20100100941A (ko) 2007-12-25 2010-09-15 메이지 세이카 가부시키가이샤 녹농균의 ⅲ형 분비 장치 구성 단백질 ｐａ1698
PL2242772T3 (pl) 2007-12-26 2015-05-29 Biotest Ag Immunokonjugaty nakierowane na CD138 i ich zastosowanie
PT2238168E (pt) 2007-12-26 2014-07-18 Biotest Ag Agentes visando cd138 e suas utilizações
AR069979A1 (es) 2007-12-26 2010-03-03 Biotest Ag Metodo para disminuir los efectos secundarios citotoxicos y mejorar la eficacia de los inmunoconjugados
ES2543201T3 (es) 2007-12-26 2015-08-17 Biotest Ag Métodos y agentes que mejoran la dirección a las células tumorales que expresan CD138
PE20091174A1 (es) 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd Formulacion liquida con contenido de alta concentracion de anticuerpo
BRPI0906492A2 (pt) 2008-01-11 2015-12-01 Synovex Corp antagonistas da caderina-11 e métodos para o tratamento de doenças inflamatórias das articulações
AU2009203350B2 (en) 2008-01-11 2014-03-13 Gene Techno Science Co., Ltd. Humanized anti-alpha9 integrin antibodies and the uses thereof
SG187457A1 (en) 2008-01-11 2013-02-28 Univ Tokyo Anti-cldn6 antibody
AU2009205995B2 (en) 2008-01-18 2014-04-03 Medimmune, Llc Cysteine engineered antibodies for site-specific conjugation
CN102037007A (zh) 2008-01-25 2011-04-27 奥尔胡斯大学 选择性外部位点抑制papp-a对igfbp-4的活性
ES2618292T3 (es) 2008-01-31 2017-06-21 Inserm - Institut National De La Sante Et De La Recherche Medicale Anticuerpos contra CD39 humano y uso de los mismos para inhibir la actividad de las células T reguladoras
PL2250279T3 (pl) 2008-02-08 2016-11-30 Przeciwciała anty-ifnar1 o zmniejszonym powinowactwie do liganda fc
GB0802474D0 (en) 2008-02-11 2008-03-19 Heptares Therapeutics Ltd Mutant proteins and methods for selecting them
US8470314B2 (en) 2008-02-29 2013-06-25 Angelica Therapeutics, Inc. Modified toxins
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
JP5661476B2 (ja) 2008-03-04 2015-01-28 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア サルアデノウイルスＳＡｄＶ−３６、−４２．１、−４２．２および−４４ならびにそれらの用途
EP2098536A1 (en) 2008-03-05 2009-09-09 4-Antibody AG Isolation and identification of antigen- or ligand-specific binding proteins
CN101970500B (zh) 2008-03-12 2013-08-14 伊姆克罗尼责任有限公司 抗tyrp1抗体
US8241643B2 (en) 2008-03-17 2012-08-14 Intercell Ag Peptides protective against S. pneumoniae and compositions, methods and uses relating thereto
WO2009115531A2 (en) 2008-03-17 2009-09-24 Universitätsklinikum Münster Yopm as delivery vehicle for cargo molecules and as biological therapeutic for immunomodulation of inflammatory reactions
EP2260102A1 (en) 2008-03-25 2010-12-15 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Treating cancer by down-regulating frizzled-4 and/or frizzled-1
CL2009000647A1 (es) 2008-04-04 2010-06-04 Chugai Pharmaceutical Co Ltd Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto.
US10000568B2 (en) 2008-04-10 2018-06-19 Cell Signaling Technology, Inc. Compositions and methods for detecting EGFR in cancer
PL2275443T3 (pl) 2008-04-11 2016-05-31 Chugai Pharmaceutical Co Ltd Cząsteczka wiążąca antygen zdolna do wiązania dwóch lub więcej cząsteczek antygenu w sposób powtarzalny
KR101746861B1 (ko) 2008-04-24 2017-06-14 가부시키가이샤 진 테크노 사이언스 세포 외 기질 단백질의 아미노산 서열 ｒｇｄ에 특이적인 인간화된 항체 및 그의 용도
EP3348573B1 (en) 2008-04-25 2020-04-22 Dyax Corp. Method of producing antibodies against fcrn and use thereof
CR20170001A (es) 2008-04-28 2017-08-10 Genentech Inc Anticuerpos anti factor d humanizados
KR20110014607A (ko) 2008-04-29 2011-02-11 아보트 러보러터리즈 이원 가변 도메인 면역글로불린 및 이의 용도
PL2282773T3 (pl) 2008-05-02 2014-08-29 Seattle Genetics Inc Sposoby i kompozycje do wytwarzania przeciwciał i pochodnych przeciwciał o obniżonej fukozylacji rdzeniowej
JP2010043063A (ja) 2008-05-09 2010-02-25 Agency For Science Technology & Research 川崎病の診断及び治療
WO2009136382A2 (en) 2008-05-09 2009-11-12 Abbott Gmbh & Co. Kg Antibodies to receptor of advanced glycation end products (rage) and uses thereof
EP2304439A4 (en) 2008-05-29 2012-07-04 Nuclea Biotechnologies Llc ANTI-phospho-AKT ANTIBODY
WO2009147781A1 (ja) 2008-06-02 2009-12-10 国立大学法人東京大学 抗がん剤
CA3138282A1 (en) 2008-06-02 2009-12-10 Dana-Farber Cancer Institute, Inc. Xbp1, cd138, and cs1 peptides
MX2010013239A (es) 2008-06-03 2011-02-24 Abbott Lab Inmunoglobulinas de dominio variable doble y usos de las mismas.
UY31861A (es) 2008-06-03 2010-01-05 Abbott Lab Inmunoglobulina con dominio variable dual y usos de la misma
CN104906581A (zh) 2008-06-05 2015-09-16 国立研究开发法人国立癌症研究中心 神经浸润抑制剂
CA2728347A1 (en) 2008-06-16 2010-01-14 Patrys Limited Lm-1 antibodies, functional fragments, lm-1 target antigen, and methods for making and using same
ES2464459T3 (es) 2008-06-25 2014-06-02 H. Lundbeck A/S Modulación del sistema receptor Trpv:receptor de dominio Vps 10p para el tratamiento del dolor
CN102076844B (zh) 2008-06-30 2013-08-07 成血管细胞系统公司 采用组合疗法的眼病和过度血管新生的治疗
MX2010014574A (es) 2008-07-08 2011-04-27 Abbott Lab Inmunoglobulinas de dominio variable dual para prostaglandina e2 y usos de las mismas.
RU2559525C2 (ru) 2008-07-08 2015-08-10 Эббви Инк Белки, связывающие простагландин е2, и их применение
CA2997870A1 (en) 2008-07-09 2010-01-14 Biogen Ma Inc. Compositions comprising antibodies to lingo or fragments thereof
CA2730201C (en) 2008-07-10 2019-02-05 Toray Industries, Inc. Anti-cd179b antibody
US8148088B2 (en) 2008-07-18 2012-04-03 Abgent Regulation of autophagy pathway phosphorylation and uses thereof
WO2010011284A2 (en) 2008-07-21 2010-01-28 The Brigham And Women's Hospital, Inc. Methods and compositions relating to synthetic beta-1,6 glucosamine oligosaccharides
CN106039307A (zh) 2008-08-05 2016-10-26 东丽株式会社 用于治疗和预防癌症的药物组合物
EP2324852B1 (en) 2008-08-07 2015-07-08 Nagasaki University Therapeutic or prophylactic agent for generalized pain syndrome
US8795981B2 (en) 2008-08-08 2014-08-05 Molecular Devices, Llc Cell detection
RU2478648C2 (ru) 2008-09-07 2013-04-10 Гликонекс Инк. Антитело против удлиненного гликосфинголипида i типа, его производные и применение
US8417011B2 (en) 2008-09-18 2013-04-09 Molecular Devices (New Milton) Ltd. Colony detection
JP2012504939A (ja) 2008-09-23 2012-03-01 ワイス・エルエルシー 架橋結合タンパク質による活性化シグナルの産生を予測するための方法
WO2010034779A2 (en) 2008-09-24 2010-04-01 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Composition and method for treatment of preterm labor
GB0817891D0 (en) 2008-09-30 2008-11-05 Medical Res Council Antibodies against il-25
JP2012504650A (ja) 2008-10-02 2012-02-23 セルタクシス，インコーポレイテッド 免疫細胞の負の走化性の調節方法
WO2010040766A1 (en) 2008-10-07 2010-04-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Neutralizing antibodies and fragments thereof directed against platelet factor-4 variant 1 (pf4v1)
KR20140101876A (ko) 2008-10-09 2014-08-20 미네르바 바이오테크놀로지 코포레이션 세포내에서 다능성을 유도하기 위한 방법
CA2740440A1 (en) 2008-10-14 2010-04-22 Dyax Corp. Use of igf-ii/igf-iie binding proteins for the treatment and prevention of systemic sclerosis-associated pulmonary fibrosis
KR20110081862A (ko) 2008-10-22 2011-07-14 제넨테크, 인크. 축삭 변성의 조절
EP2350270B1 (en) 2008-10-24 2018-03-07 The Government of the United States of America, as represented by the Secretary, Department of Health & Human Services Human ebola virus species and compositions and methods thereof
US8871202B2 (en) 2008-10-24 2014-10-28 Lpath, Inc. Prevention and treatment of pain using antibodies to sphingosine-1-phosphate
WO2010050528A1 (ja) 2008-10-28 2010-05-06 塩野義製薬株式会社 抗ｍｕｃ１抗体
ES2732504T3 (es) 2008-10-29 2019-11-22 Circular Commitment Company Procedimientos y agentes para el diagnóstico y tratamiento del carcinoma hepatocelular
EP2346900A1 (en) 2008-10-29 2011-07-27 Wyeth LLC Methods for purification of single domain antigen binding molecules
CN104740631B (zh) 2008-10-29 2019-04-16 阿布林克斯公司 单域抗原结合性分子的制剂
EP2350269B1 (en) 2008-10-31 2015-09-09 The Trustees Of The University Of Pennsylvania Simian adenoviruses with sadv-46 hexon capsid proteins and uses thereof
US8642280B2 (en) 2008-11-07 2014-02-04 Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Teneurin and cancer
BRPI0921845A2 (pt) 2008-11-12 2019-09-17 Medimmune Llc formulação aquosa estéril estável, forma de dosagem unitária farmacêutica, seringa pré-carregada, e, métodos para tratar uma doença ou distúrbio, para tratar ou prevenir rejeição, para esgotar células t que expressam icos em um paciente humano, e para interromper arquitetura central germinal em um órgão linfóide secundário de um primata
EP2191840A1 (en) 2008-11-28 2010-06-02 Sanofi-Aventis Antitumor combinations containing antibodies recognizing specifically CD38 and melphalan
EP2191843A1 (en) 2008-11-28 2010-06-02 Sanofi-Aventis Antitumor combinations containing antibodies recognizing specifically CD38 and cyclophosphamide
EP2191842A1 (en) 2008-11-28 2010-06-02 Sanofi-Aventis Antitumor combinations containing antibodies recognizing specifically CD38 and cytarabine
EP2191841A1 (en) 2008-11-28 2010-06-02 Sanofi-Aventis Antitumor combinations containing antibodies recognizing specifically CD38 and vincristine
US8401799B2 (en) 2008-12-05 2013-03-19 Lpath, Inc. Antibody design using anti-lipid antibody crystal structures
EP2198884A1 (en) 2008-12-18 2010-06-23 Centre National de la Recherche Scientifique (CNRS) Monoclonal antibodies directed against LG4-5 domain of alpha3 chain of human laminin-5
GB0823309D0 (en) 2008-12-19 2009-01-28 Univ Bath Functionalising reagents and their uses
EP2373343B1 (en) 2008-12-19 2015-02-11 Philogen S.p.A. Immunocytokines for tumour therapy with chemotherapeutic agents
AU2009328505B2 (en) 2008-12-19 2014-11-27 Panima Pharmaceuticals Ag Human anti-alpha-synuclein autoantibodies
RU2744176C2 (ru) 2008-12-19 2021-03-03 Макродженикс, Инк. Ковалентные диантитела и их применение
UY32341A (es) 2008-12-19 2010-07-30 Glaxo Group Ltd Proteínas de unión antígeno novedosas
CN102439041B (zh) 2008-12-19 2016-05-04 H.隆德贝克有限公司 用于治疗精神和行为障碍的对Vps10p-结构域受体家族的调节
JP5756292B2 (ja) 2008-12-22 2015-07-29 中外製薬株式会社 抗ｈｓ６ｓｔ２抗体及びその用途
WO2010075303A1 (en) 2008-12-23 2010-07-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Splicing factors with a puf protein rna-binding domain and a splicing effector domain and uses of same
WO2010075417A1 (en) 2008-12-23 2010-07-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Survivin specific t cell receptor for treating cancer
EP2385114A4 (en) 2008-12-25 2012-08-08 Univ Tokyo CANCER TREATMENT DIAGNOSIS WITH ANTI-TM4SF20 ANTIBODY
KR20110099762A (ko) 2008-12-26 2011-09-08 고쿠리츠다이가쿠호우진 도쿄다이가쿠 항ｌｇｒ７항체를 사용하는 암의 진단 및 치료
CN102341411A (zh) 2008-12-31 2012-02-01 比奥根艾迪克Ma公司 抗-淋巴细胞毒素抗体
CA2748291A1 (en) 2009-01-07 2010-07-15 Philogen S.P.A. Cancer treatment
ES2549362T3 (es) 2009-01-07 2015-10-27 Philogen S.P.A. Antígenos asociados a endometriosis
CA2749572A1 (en) 2009-01-14 2010-07-22 Iq Therapeutics Bv Combination antibodies for the treatment and prevention of disease caused by bacillus anthracis and related bacteria and their toxins
WO2010085510A1 (en) 2009-01-20 2010-07-29 Zadeh Homayoun H Antibody mediated osseous regeneration
US8313915B2 (en) 2009-01-21 2012-11-20 Gundersen Lutheran Medical Foundation, Inc. Early detection of canine lyme disease by specific peptides and antibodies
EP2210903A1 (en) 2009-01-21 2010-07-28 Monoclonal Antibodies Therapeutics Anti-CD160 monoclonal antibodies and uses thereof
RU2011126896A (ru) 2009-01-23 2013-02-27 Дзе Хенри М. Джексон Фаундейшн Фо Дзе Эдвенсмент Оф Милитэри Медисин, Инк. Композиция и полипептид для стимулирования иммунологической реакции на шига токсин 2 типа
WO2010084327A2 (en) 2009-01-26 2010-07-29 Electrophoretics Limited Methods
SG172855A1 (en) 2009-01-29 2011-08-29 Abbott Lab Il-1 binding proteins
WO2010087927A2 (en) 2009-02-02 2010-08-05 Medimmune, Llc Antibodies against and methods for producing vaccines for respiratory syncytial virus
US9085795B2 (en) 2009-02-04 2015-07-21 Molecular Innovations, Inc. Methods for screening candidate agents for modulating prorenin and renin, assays for detecting prorenin and antibodies
US20130243779A1 (en) 2009-02-05 2013-09-19 Intercell Ag Peptides protective against e. faecalis, methods and uses relating thereto
WO2010091328A1 (en) 2009-02-09 2010-08-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Diagnostic and therapeutic uses of gnptab, gnptg, and nagpa in stuttering
EP2396035A4 (en) 2009-02-12 2012-09-12 Human Genome Sciences Inc USE OF ANTAGONISTS OF PROTEIN STIMULATING LYMPHOCYTES B TO PROMOTE GRAFT TOLERANCE
EP2405938A2 (en) 2009-02-13 2012-01-18 Intercell AG Nontypable haemophilus influenzae antigens
WO2010096658A1 (en) 2009-02-19 2010-08-26 The Cleveland Clinic Foundation Corin as a marker for heart failure
GB0902916D0 (en) 2009-02-20 2009-04-08 Fusion Antibodies Ltd Antibody therapy
US8030026B2 (en) 2009-02-24 2011-10-04 Abbott Laboratories Antibodies to troponin I and methods of use thereof
GB0903325D0 (en) 2009-02-26 2009-04-08 Univ Aberdeen Antibody molecules
ES2589769T3 (es) 2009-02-27 2016-11-16 Massachusetts Institute Of Technology Proteínas modificadas con alta afinidad por quelatos de DOTA
NZ611324A (en) 2009-03-05 2015-02-27 Abbvie Inc Il-17 binding proteins
WO2010100247A1 (en) 2009-03-06 2010-09-10 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research Novel therapy for anxiety
WO2010104208A1 (en) 2009-03-10 2010-09-16 Gene Techno Science Co., Ltd. Generation, expression and characterization of the humanized k33n monoclonal antibody
EP2406290B1 (en) 2009-03-10 2017-07-05 Baylor Research Institute Antigen presenting cell targeted cancer vaccines
CN105837691B (zh) 2009-03-10 2021-06-29 贝勒研究院 靶向抗原呈递细胞的癌症疫苗
ES2584956T3 (es) 2009-03-10 2016-09-30 Baylor Research Institute Anticuerpos anti-CD40 y usos de los mismos
JP2010210772A (ja) 2009-03-13 2010-09-24 Dainippon Screen Mfg Co Ltd 液晶表示装置の製造方法
EP2408818A1 (en) 2009-03-17 2012-01-25 Université de la Méditerranée Btla antibodies and uses thereof
WO2010111180A1 (en) 2009-03-24 2010-09-30 Teva Biopharmaceuticals Usa, Inc. Humanized antibodies against light and uses thereof
US20120110684A1 (en) 2009-03-24 2012-05-03 INSERM (Institut National de la Sante st de la Recherche Medicale)- Method for Diagnosing or Predicting a Non Syndromic Autosomal Recessive Optic Atrophy, or a Risk of a Non Syndromic Autosomal Recessive Optic Atrophy
WO2010110346A1 (ja) 2009-03-24 2010-09-30 独立行政法人理化学研究所 白血病幹細胞マーカー
EP2412808B1 (en) 2009-03-25 2016-09-07 Tohoku University Lh-type bispecific antibody
WO2010115786A1 (en) 2009-04-01 2010-10-14 Glaxo Group Limited Anti-il-23 immunoglobulins
WO2010112034A2 (en) 2009-04-02 2010-10-07 Aarhus Universitet Compositions and methods for treatment and diagnosis of synucleinopathies
GB0905972D0 (en) 2009-04-06 2009-05-20 Medical Res Council Antibodies against IL-17BR
ES2571235T3 (es) 2009-04-10 2016-05-24 Kyowa Hakko Kirin Co Ltd Procedimiento para el tratamiento de un tumor sanguíneo que utiliza el anticuerpo anti-TIM-3
DE202010018378U1 (de) 2009-04-10 2016-04-07 Tufts Medical Center, Inc. PAR-1-Aktivierung durch Metalloproteinase-1 (MMP-1)
EP2241323A1 (en) 2009-04-14 2010-10-20 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Tenascin-W and brain cancers
RU2595379C2 (ru) 2009-04-16 2016-08-27 АббВай Биотерапеутикс Инк. АНТИТЕЛА ПРОТИВ TNF-α И ИХ ПРИМЕНЕНИЯ
US9079957B2 (en) 2009-04-16 2015-07-14 The University Of Tokyo Diagnosis and treatment of cancer using anti-TMPRSS11E antibody
AU2010239131A1 (en) 2009-04-21 2011-11-17 Genetic Technologies Limited Methods for obtaining fetal genetic material
CN102459342B (zh) 2009-04-27 2015-01-07 协和发酵麒麟株式会社 用于治疗血液肿瘤的抗il-3ra抗体
WO2010126972A1 (en) 2009-04-29 2010-11-04 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Erg monoclonal antibodies
AU2010242338B2 (en) 2009-05-01 2013-12-19 Perseus Proteomics Inc. Anti-cadherin antibody
EP2427479B1 (en) 2009-05-07 2018-11-21 The Regents of The University of California Antibodies and methods of use thereof
EP2270053A1 (en) 2009-05-11 2011-01-05 U3 Pharma GmbH Humanized AXL antibodies
FR2945538B1 (fr) 2009-05-12 2014-12-26 Sanofi Aventis Anticorps humanises specifiques de la forme protofibrillaire du peptide beta-amyloide.
CN102459628A (zh) 2009-05-13 2012-05-16 基酶有限公司 抗人cd52 免疫球蛋白
CN102459344A (zh) 2009-05-15 2012-05-16 中外制药株式会社 抗axl抗体
GB0908425D0 (en) 2009-05-15 2009-06-24 Medical Res Council Medical use
HUE026456T2 (en) 2009-05-27 2016-05-30 Biotempus Ltd Procedure for curing diseases
US8846031B2 (en) 2009-05-29 2014-09-30 The Trustees Of The University Of Pennsylvania Simian adenovirus 41 and uses thereof
EP2436397B1 (en) 2009-05-29 2017-05-10 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition containing antagonist of egf family ligand as component
TR201907573T4 (tr) 2009-06-03 2019-06-21 Immunogen Inc Konjugasyon yöntemleri̇
EP2260864A1 (en) 2009-06-10 2010-12-15 University of Melbourne Therapeutic applications
NZ596837A (en) 2009-06-17 2014-02-28 Abbvie Biotherapeutics Inc Anti-vegf antibodies and their uses
EP2445520A4 (en) 2009-06-22 2013-03-06 Medimmune Llc MANIPULATED FC REGIONS FOR LOCAL SPECIFIC CONJUGATION
GB0910725D0 (en) 2009-06-22 2009-08-05 Heptares Therapeutics Ltd Mutant proteins and methods for producing them
EP2445531A4 (en) 2009-06-24 2013-04-24 Lpath Inc PROCESS FOR INCREASED NEURONAL DIFFERENTIATION USING ANTIBODIES TO LYSOPHOSPHACIDIC ACID
WO2011000543A1 (en) 2009-06-30 2011-01-06 Philochem Ag Murine antibody display library
US20120107270A1 (en) 2009-06-30 2012-05-03 Manuela Kaspar Immunocytokines In Combination With Anti-ErbB Antibodies For The Treatment Of Cancer
JP5871798B2 (ja) 2009-07-02 2016-03-01 エムユーエスシー ファウンデーション フォー リサーチ ディベロップメント 肝再生を刺激する方法
KR101962476B1 (ko) 2009-07-03 2019-03-26 아비펩 피티와이 리미티트 면역성 접합체 및 그 제조방법
WO2011003996A1 (en) 2009-07-09 2011-01-13 F. Hoffmann-La Roche Ag In vivo tumor vasculature imaging
CN104710504B (zh) 2009-07-22 2019-09-13 锕医药股份有限公司 用于制备放射性免疫缀合物的方法
US20120230918A1 (en) 2009-07-28 2012-09-13 Hoffmann-La-Roche Inc. Non-invasive in vivo optical imaging method
ES2513292T3 (es) 2009-07-31 2014-10-24 Genentech, Inc. Inhibición de metástasis tumoral usando anticuerpos anti-G-CSF
WO2011013786A1 (ja) 2009-07-31 2011-02-03 Maeda Shin 癌の転移抑制剤
EP2462451B1 (en) 2009-08-05 2016-02-17 Nexigen GmbH Human hcv-interacting proteins and methods of use
WO2011015333A2 (en) 2009-08-05 2011-02-10 Philogen S.P.A. Targeting of bone marrow neovasculature
US8840889B2 (en) 2009-08-13 2014-09-23 The Johns Hopkins University Methods of modulating immune function
BR112012003064B8 (pt) 2009-08-13 2021-05-25 Crucell Holland Bv anticorpo ou fragmento de ligação de antígeno do mesmo, combinação que os compreende, método de detecção de infecção por rsv, moléculas de ácido nucléico, e método de produção de um anticorpo ou fragmento de ligação de antígeno do mesmo
CA2771436A1 (en) 2009-08-17 2011-02-24 Forerunner Pharma Research Co., Ltd. Pharmaceutical composition comprising anti-hb-egf antibody as active ingredient
EP2467492A4 (en) 2009-08-18 2013-01-09 Harvard College METHODS AND COMPOSITIONS FOR THE TREATMENT OF PROLIFERATIVE AND PATHOGENIC DISEASES
GB0914446D0 (en) 2009-08-18 2009-09-30 King S College London Bioconjugates and their uses in imaging
GB0914691D0 (en) 2009-08-21 2009-09-30 Lonza Biologics Plc Immunoglobulin variants
WO2011024114A1 (en) 2009-08-25 2011-03-03 Ecole Polytechnique Federale De Lausanne (Epfl) Targeting extracellular matrix molecules for the treatment of cancer
MX2012002400A (es) 2009-08-26 2012-06-25 Commw Scient Ind Res Org Procesos para producir materia prima de la seda.
EP2292266A1 (en) 2009-08-27 2011-03-09 Novartis Forschungsstiftung, Zweigniederlassung Treating cancer by modulating copine III
CN102002104A (zh) 2009-08-28 2011-04-06 江苏先声药物研究有限公司 一种抗vegf的单克隆抗体及含有该抗体的药物组合物
PE20121647A1 (es) 2009-08-29 2012-12-31 Abbvie Inc Proteinas terapeuticas de union a dll4
AU2010286427A1 (en) 2009-08-31 2012-03-08 Abbott Biotherapeutics Corp. Use of an immunoregulatory NK cell population for monitoring the efficacy of anti-IL-2R antibodies in multiple sclerosis patients
UY32870A (es) 2009-09-01 2011-02-28 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
RU2595409C2 (ru) 2009-09-03 2016-08-27 Мерк Шарп И Доум Корп., Анти-gitr-антитела
CA2774326C (en) 2009-09-14 2023-11-07 Donald Bellgrau Modulation of yeast-based immunotherapy products and responses
US20120244170A1 (en) 2009-09-22 2012-09-27 Rafal Ciosk Treating cancer by modulating mex-3
TW201118166A (en) 2009-09-24 2011-06-01 Chugai Pharmaceutical Co Ltd HLA class I-recognizing antibodies
EP2305285A1 (en) 2009-09-29 2011-04-06 Julius-Maximilians-Universität Würzburg Means and methods for treating ischemic conditions
JP5934099B2 (ja) 2009-10-01 2016-06-15 アメリカ合衆国 抗血管内皮増殖因子受容体−２キメラ抗原受容体及び癌の治療のためのその使用
US9395356B2 (en) 2009-10-02 2016-07-19 The National Veterinary Institute Piscine reovirus immunogenic compositions
AR078470A1 (es) 2009-10-02 2011-11-09 Sanofi Aventis Anticuerpos que se unen especificamente al receptor epha2
EP2483424B1 (en) 2009-10-02 2013-12-04 INSERM - Institut National de la Santé et de la Recherche Médicale Method for the diagnosis/prognosis of age-related macular degeneration
US9096877B2 (en) 2009-10-07 2015-08-04 Macrogenics, Inc. Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use
ES2666372T3 (es) 2009-10-11 2018-05-04 Biogen Ma Inc. Ensayos relacionados con anti-VLA-4
WO2011054644A1 (en) 2009-10-14 2011-05-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. A low density lipoprotein-related protein 1 splice variant as cancer marker
WO2011045352A2 (en) 2009-10-15 2011-04-21 Novartis Forschungsstiftung Spleen tyrosine kinase and brain cancers
RU2012119756A (ru) 2009-10-15 2013-11-20 Эбботт Лэборетриз Иммуноглобулины с двумя вариабельными доменами и их применение
LT2488551T (lt) 2009-10-16 2018-10-25 Progastrine Et Cancers S.A R.L. Monokloniniai antikūnai prieš progastriną ir jų panaudojimas
SG10201406763WA (en) 2009-10-22 2014-11-27 Genentech Inc Modulation of axon degeneration
US8658175B2 (en) 2009-10-28 2014-02-25 Abbvie Biotherapeutics Inc. Anti-EGFR antibodies and their uses
UY32979A (es) 2009-10-28 2011-02-28 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
WO2011053777A1 (en) 2009-10-30 2011-05-05 Abbott Biotherapeutics Corp. Use of immunoregulatory nk cell populations for predicting the efficacy of anti-il-2r antibodies in multiple sclerosis patients
US20120213801A1 (en) 2009-10-30 2012-08-23 Ekaterina Gresko Phosphorylated Twist1 and cancer
TW201121568A (en) 2009-10-31 2011-07-01 Abbott Lab Antibodies to receptor for advanced glycation end products (RAGE) and uses thereof
JP6077856B2 (ja) 2009-11-04 2017-02-08 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 操作型抗ｔｓｌｐ抗体本出願は、米国特許仮出願第６１／２９７，００８号（２０１０年１月２１日出願）、および米国特許仮出願第６１／２５８，０５１号（２００９年１１月４日出願）の利益を主張し、該仮出願は各々、引用によりその全体が本明細書に組み込まれる。
EP2496604B1 (en) 2009-11-06 2017-08-23 IDEXX Laboratories, Inc. Canine anti-cd20 antibodies
US9588121B2 (en) 2009-11-06 2017-03-07 Go Therapeutics, Inc. Method for early detection of cancer
WO2011062112A1 (ja) 2009-11-18 2011-05-26 国立大学法人東北大学 ヒト型化抗ｅｇｆｒ抗体可変領域の高機能性変異体
EP2332929A1 (en) 2009-11-25 2011-06-15 ArisGen SA Orthoester derivatives of crown ethers as carriers for pharmaceutical and diagnostic compositions
NZ600454A (en) 2009-11-30 2014-10-31 Univ Queensland Fibronectin: growth factor chimeras
US9872905B2 (en) 2009-12-01 2018-01-23 President And Fellows Of Harvard College Modulation of NK cell antigen specific effector activity by modulation of CXCR6 (CD186)
US8324352B2 (en) 2009-12-07 2012-12-04 Decimmune Therapeutics, Inc. Anti-inflammatory antibodies and uses therefor
WO2011070045A1 (en) 2009-12-08 2011-06-16 Abbott Gmbh & Co. Kg Monoclonal antibodies against the rgm a protein for use in the treatment of retinal nerve fiber layer degeneration
ES2594893T3 (es) 2009-12-16 2016-12-23 Abbvie Biotherapeutics Inc. Anticuerpos anti HER2 y sus usos
MX2012007489A (es) 2009-12-23 2012-11-29 4Antibody Ag Miembros enlazadores para citomegalovirus.
KR101961495B1 (ko) 2009-12-23 2019-03-22 아비펩 피티와이 리미티트 면역-컨쥬게이트 및 그 제조방법 ２
HUE039605T2 (hu) 2010-01-06 2019-01-28 Dyax Corp Plazma kallikreint kötõ proteinek
US9217032B2 (en) 2010-01-08 2015-12-22 Les Laboratoires Servier Methods for treating colorectal cancer
US9487582B2 (en) 2010-01-08 2016-11-08 Institut National De La Sante Et De La Recherche Medicale (Inserm) Methods for treating pancreatic cancer
US8900817B2 (en) 2010-01-08 2014-12-02 Les Laboratories Servier Progastrin and liver pathologies
WO2011088193A2 (en) 2010-01-13 2011-07-21 University Of Medicine And Dentistry Of New Jersey Fluorophore chelated lanthanide luminiscent probes with improved quantum efficiency
AR080428A1 (es) 2010-01-20 2012-04-11 Chugai Pharmaceutical Co Ltd Formulaciones liquidas estabilizadas contentivas de anticuerpos
EA023700B1 (ru) 2010-01-28 2016-07-29 Глаксо Груп Лимитед Cd127-связывающие белки
JP5918540B2 (ja) 2010-01-29 2016-05-18 中外製薬株式会社 抗ｄｌｌ３抗体
JP5104996B2 (ja) 2010-01-29 2012-12-19 東レ株式会社 ポリ乳酸系樹脂シート
EP2531609A1 (en) 2010-02-02 2012-12-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and therapy of retinitis pigmentosa
US9056068B2 (en) 2010-02-04 2015-06-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Vaccine and methods of use against Strongyloide stercoralis infection
CN102822335B (zh) 2010-02-04 2015-09-30 东丽株式会社 癌的治疗和/或预防用药物组合物
KR101758117B1 (ko) 2010-02-04 2017-07-14 도레이 카부시키가이샤 암의 치료 및/또는 예방용 의약 조성물
HUE030102T2 (en) 2010-02-04 2017-04-28 Toray Industries A pharmaceutical composition comprising anti-caprin-1 antibodies for the treatment and / or prevention of cancer
BR112012018951C8 (pt) 2010-02-04 2020-06-23 Toray Industries anticorpo monoclonal, composição farmacêutica, combinação farmacêutica, uso de um anticorpo, uso de uma composição farmacêutica e uso de uma combinação farmacêutica
CN102821788B (zh) 2010-02-04 2016-11-16 东丽株式会社 癌的治疗和/或预防用药物组合物
SG182783A1 (en) 2010-02-09 2012-09-27 Glaxo Group Ltd Treatment of a metabolic disorder
CA2789310C (en) 2010-02-10 2018-01-09 Fujifilm Ri Pharma Co., Ltd. Radioactive metal-labeled anti-cadherin antibody
CN102933231B (zh) 2010-02-10 2015-07-29 伊缪诺金公司 Cd20抗体及其用途
WO2011103389A1 (en) 2010-02-19 2011-08-25 Cornell University Method to treat autoimmune demyelinating diseases and other autoimmune or inflammatory diseases
US20120321557A1 (en) 2010-02-26 2012-12-20 Forerunner Pharma Research Co., Ltd. Anti-icam3 antibody and use thereof
WO2011109298A2 (en) 2010-03-02 2011-09-09 Abbott Laboratories Therapeutic dll4 binding proteins
EP3056510B1 (en) 2010-03-03 2018-10-03 The University Of British Columbia Oligomer-specific amyloid beta epitope and antibodies
UA108227C2 (xx) 2010-03-03 2015-04-10 Антигензв'язуючий білок
JP5845171B2 (ja) 2010-03-04 2016-01-20 大日本住友製薬株式会社 炎症性腸疾患用薬剤
WO2011108714A1 (ja) 2010-03-04 2011-09-09 中外製薬株式会社 抗体定常領域改変体
WO2011107586A1 (en) 2010-03-05 2011-09-09 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research, Smoc1, tenascin-c and brain cancers
EP2547359B1 (en) 2010-03-15 2016-03-09 The Board of Trustees of the University of Illionis Inhibitors of beta integrin-g protein alpha subunit binding interactions
EP2368428A1 (en) 2010-03-16 2011-09-28 Institut National De La Recherche Agronomique Obtention of a rex animal by molecular methods based on the alteration of the LIPH function
JP5829672B2 (ja) 2010-03-24 2015-12-09 レ ラボラトワール セルヴィエ 結腸直腸及び胃腸癌の予防
CA2794551A1 (en) 2010-03-26 2011-09-29 Westfaelische Wilhelms-Universitaet Muenster Substitute therapy for glucocorticoids
TWI667257B (zh) 2010-03-30 2019-08-01 中外製藥股份有限公司 促進抗原消失之具有經修飾的ＦｃＲｎ親和力之抗體
WO2011123518A1 (en) 2010-03-31 2011-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adenosine receptor agonists for the treatment and prevention of vascular or joint capsule calcification disorders
AR080698A1 (es) 2010-04-01 2012-05-02 Imclone Llc Anticuerpo o fragmento del mismo que especificamente enlaza la variante de csf -1r humano, composicion farmaceutica que lo comprende, su uso para la manufactura de un medicamento util para el tratamiento de cancer y metodo para determinar si un sujeto es candidato para tratamiento de cancer basado e
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
PL3202789T3 (pl) 2010-04-16 2020-09-21 Biogen Ma Inc. Przeciwciała anty-vla-4
WO2011131611A1 (en) 2010-04-19 2011-10-27 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Modulating xrn1
WO2011133658A1 (en) 2010-04-22 2011-10-27 Boston Medical Center Corporation Compositions and methods for targeting and delivering therapeutics into cells
ES2596431T3 (es) 2010-05-04 2017-01-09 The Brigham And Women's Hospital, Inc. Antagonista de cadherina-11 para el tratamiento de fibrosis
EP2567234B1 (en) 2010-05-07 2018-09-19 F.Hoffmann-La Roche Ag Diagnostic method for the detection of cells ex vivo
UY33386A (es) 2010-05-14 2011-12-30 Abbott Laboratoires Proteínas de unión a il-1
GB201008541D0 (en) 2010-05-21 2010-07-07 Univ Geneve Diagnostic methods
WO2011145085A2 (en) 2010-05-21 2011-11-24 Procognia (Israel) Ltd Novel antibodies and methods of use for the treatment and diagnosis of cancer
JP5904552B2 (ja) 2010-05-28 2016-04-13 国立研究開発法人国立がん研究センター 膵癌治療剤
JP6051049B2 (ja) 2010-05-28 2016-12-21 中外製薬株式会社 抗腫瘍ｔ細胞応答増強剤
CN103025354A (zh) 2010-06-02 2013-04-03 大日本住友制药株式会社 自身免疫疾病和变应性疾病的治疗药
UY33421A (es) 2010-06-03 2011-12-30 Glaxo Wellcome House Proteinas de union al antígeno humanizados
WO2011161545A2 (en) 2010-06-04 2011-12-29 The Netherlands Cancer Institute Non-hydrolyzable protein conjugates, methods and compositions related thereto
GB201009455D0 (en) 2010-06-04 2010-07-21 King S College London Nanoparticles and their uses in molecular imaging
CN103097414B (zh) 2010-06-09 2016-05-18 伦敦大学玛丽皇后和威斯特-弗尔德学院 膜联蛋白1抗体
US20130089538A1 (en) 2010-06-10 2013-04-11 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute forBiomedical Researh Treating cancer by modulating mammalian sterile 20-like kinase 3
RU2615684C2 (ru) 2010-06-14 2017-04-06 Ликера Биомед Са Специфическое антитело к s100a4 или его фрагмент (варианты), способ их получения (варианты), фармацевтическая композиция, их содержащая, гибридомная клеточная линия (варианты), конъюгат, композиция, способ предупреждения и/или лечения рака, метастазирования, ангиогенеза и воспалительных заболеваний, способ и набор для диагностики рака или заболевания, ассоциированного с воспалением, (варианты), способ детекции s100a4, способ создания индивидуальной терапии
US9315585B2 (en) 2010-06-19 2016-04-19 Memorial Sloan Kettering Cancer Center Anti-GD2 antibodies
AU2011268780A1 (en) 2010-06-25 2013-02-07 Aston University Glycoproteins having lipid mobilizing properties and therapeutic uses thereof
WO2012006500A2 (en) 2010-07-08 2012-01-12 Abbott Laboratories Monoclonal antibodies against hepatitis c virus core protein
UY33492A (es) 2010-07-09 2012-01-31 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
JP5744196B2 (ja) 2010-07-09 2015-07-08 クルセル ホランド ベー ヴェー 抗ヒト呼吸器多核体ウイルス（ｒｓｖ）抗体および使用の方法
US8747858B2 (en) 2010-07-13 2014-06-10 Merck Sharp & Dohme Corp. Staphylococcus aureus surface protein SA1789 and protective vaccine based thereon
RS57215B1 (sr) 2010-07-15 2018-07-31 Adheron Therapeutics Inc Humanizovana antitela koja ciljaju ec1 domen kadherina-11 i kompozicije i postupci koji su u vezi sa njima
CN108314733A (zh) 2010-07-16 2018-07-24 埃博灵克斯股份有限公司 修饰的单结构域抗原结合分子及其应用
WO2012010696A1 (en) 2010-07-23 2012-01-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for cancer management targeting co-029
AU2011284908B2 (en) 2010-07-26 2015-05-21 Centre National De La Recherche Scientifique (Cnrs) Methods and compositions for liver cancer therapy
HUE063115T2 (hu) 2010-07-29 2023-12-28 Buzzard Pharmaceuticals AB Kiméra I-es típusú IL-1 receptor antagonisták
CN103154025B (zh) 2010-08-02 2015-07-01 宏观基因有限公司 共价双抗体及其用途
TW201206473A (en) 2010-08-03 2012-02-16 Abbott Lab Dual variable domain immunoglobulins and uses thereof
JP2012034668A (ja) 2010-08-12 2012-02-23 Tohoku Univ ヒト型化抗ｅｇｆｒ抗体リジン置換可変領域断片及びその利用
EP2420250A1 (en) 2010-08-13 2012-02-22 Universitätsklinikum Münster Anti-Syndecan-4 antibodies
EP2603606B1 (en) 2010-08-12 2014-06-04 INSERM - Institut National de la Santé et de la Recherche Médicale Methods and kits for of identifying a premature infant at risk of having or developing bronchopulmonary dysplasia
MX358739B (es) 2010-08-14 2018-09-03 Abbvie Inc Star Proteinas de union a amiloide beta.
US9139879B2 (en) 2010-08-19 2015-09-22 Howard Florey Institute TAM receptors and TAM receptor ligands in detection and modulation of neuropathological disease
SI3333188T1 (sl) 2010-08-19 2022-04-29 Zoetis Belgium S.A. Protitelesa proti NGF in njihova uporaba
CA2807607A1 (en) 2010-08-20 2012-02-23 Wyeth Llc Cell culture of growth factor-free adapted cells
AU2011293558B2 (en) 2010-08-23 2014-07-31 Board Of Regents, The University Of Texas System Anti-OX40 antibodies and methods of using the same
WO2012027494A1 (en) 2010-08-24 2012-03-01 Regents Of The University Of Minnesota Bispecific targeting reagents
JP2013539364A (ja) 2010-08-26 2013-10-24 アッヴィ・インコーポレイテッド 二重可変ドメイン免疫グロブリンおよびその使用
EP2609431B1 (en) 2010-08-27 2017-05-10 University of Zurich Method for target and drug validation in inflammatory and/or cardiovascular diseases
WO2012028697A1 (en) 2010-09-01 2012-03-08 Eth Zürich, Institute Of Molecular Biology And Biophysics Affinity purification system based on donor strand complementation
ES2715177T3 (es) 2010-09-01 2019-06-03 Genzyme Corp Tratamiento de infarto de miocardio usando antagonistas de tgf-beta
US20130171159A1 (en) 2010-09-10 2013-07-04 Brian Arthur Hemmings Phosphorylated twist1 and metastasis
EP3533802B1 (en) 2010-09-21 2021-03-17 The United States of America, as represented by The Secretary, Department of Health and Human Services Anti-ssx-2 t cell receptors and related materials and methods of use
WO2012038744A2 (en) 2010-09-22 2012-03-29 Genome Research Limited Detecting mutations
US9362094B2 (en) 2010-09-22 2016-06-07 The Board Of Trustees Of The University Of Arkansas Biomarkers for determining breast cancer bone metastasis
US20120244141A1 (en) 2010-09-28 2012-09-27 Boehringer Ingelheim International Gmbh Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors
US8497138B2 (en) 2010-09-30 2013-07-30 Genetix Limited Method for cell selection
JP5843170B2 (ja) 2010-09-30 2016-01-13 国立研究開発法人理化学研究所 グリオーマの治療方法、グリオーマの検査方法、所望の物質をグリオーマに送達させる方法、及びそれらの方法に用いられる薬剤
GB201016864D0 (en) 2010-10-06 2010-11-17 Univ Aston Therapeutic methods
EP2627672B1 (en) 2010-10-11 2018-08-01 Biogen Idec International Neuroscience GmbH Human anti-tau antibodies
CA2813796C (en) 2010-10-18 2019-01-15 Mediapharma S.R.L. Erbb3 binding antibody
WO2012054825A1 (en) 2010-10-22 2012-04-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-mage-a3 t cell receptors and related materials and methods of use
EP2632481A1 (en) 2010-10-25 2013-09-04 Regents Of The University Of Minnesota Therapeutic composition for treatment of glioblastoma
MX357167B (es) 2010-10-27 2018-06-28 Univ New York State Res Found Composiciones que se dirigen al dominio extracelular soluble de e-caderina y metodos relacionados para terapia de cancer.
EP3404043B1 (en) 2010-10-29 2022-10-26 Perseus Proteomics Inc. Anti-cdh3 antibody having high internalization capacity
WO2012061281A1 (en) 2010-11-04 2012-05-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Diagnostic assays and methods of use for detection of filarial infection
GB201019118D0 (en) 2010-11-11 2010-12-29 King S College Conjugates and their uses in molecular imaging
WO2012065034A1 (en) 2010-11-12 2012-05-18 Merck Sharp & Dohme Corp. Enolase peptide conjugate vaccines against staphylococcus aureus
WO2012065937A1 (en) 2010-11-15 2012-05-24 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research Anti-fungal agents
KR101398363B1 (ko) 2010-11-17 2014-05-22 추가이 세이야쿠 가부시키가이샤 혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자
US9072766B2 (en) 2010-11-18 2015-07-07 Beth Israel Deaconess Medical Center, Inc. Methods of treating obesity by inhibiting nicotinamide N-methyl transferase (NNMT)
SG10201509499RA (en) 2010-11-19 2015-12-30 Eisai R&D Man Co Ltd Neutralizing anti-ccl20 antibodies
JO3455B1 (ar) 2010-11-23 2020-07-05 Glaxo Group Ltd بروتينات ربط مولد ضد ب أونكوستاتين m (osm )
EP2643465B1 (en) 2010-11-23 2016-05-11 The Trustees Of The University Of Pennsylvania Subfamily e simian adenovirus a1321 and uses thereof
MX365235B (es) 2010-11-30 2019-05-28 Chugai Pharmaceutical Co Ltd Molécula de unión a antígeno capaz de unir repetidamente a la pluralidad de moléculas de antígeno.
PL2647707T3 (pl) 2010-11-30 2019-02-28 Chugai Seiyaku Kabushiki Kaisha Środek terapeutyczny wywołujący cytotoksyczność
UA112170C2 (uk) 2010-12-10 2016-08-10 Санофі Протипухлинна комбінація, що містить антитіло, яке специфічно розпізнає cd38, і бортезоміб
WO2012080769A1 (en) 2010-12-15 2012-06-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-cd277 antibodies and uses thereof
CN103380145B (zh) 2010-12-17 2016-10-12 生物控股有限公司 人类抗-sod1抗体
WO2012087943A2 (en) 2010-12-20 2012-06-28 The Regents Of The University Of Michigan Inhibitors of the epidermal growth factor receptor-heat shock protein 90 binding interaction
BR112013015508B1 (pt) 2010-12-20 2022-04-05 Medimmune Limited Molécula de anticorpo para il-18 humana, domínio vh isolado e domínio vl isolado, composição, uso de uma molécula de anticorpo ou do domínio vh isolado e do domínio vl isolado, molécula de ácido nucleico isolada, célula hospedeira procariótica recombinante, método para produzir um anticorpo, e método in vitro para medir il-18 em uma amostra de um indivíduo
WO2012088094A2 (en) 2010-12-21 2012-06-28 Abbott Laboratories Il-1 binding proteins
JP6009455B2 (ja) 2010-12-21 2016-10-19 アッヴィ・インコーポレイテッド Ｉｌ−１アルファおよびベータ二重特異的二重可変ドメイン免疫グロブリンおよびその使用
DK2654789T3 (en) 2010-12-22 2018-09-03 Orega Biotech ANTIBODIES AGAINST HUMAN CD39 AND USE THEREOF
ES2720136T3 (es) 2010-12-22 2019-07-18 Teva Pharmaceuticals Australia Pty Ltd Anticuerpo modificado con semivida mejorada
EP2659910B1 (en) 2010-12-27 2016-11-09 National University Corporation Nagoya University Screening method for a compound capable of suppressing receptor tyrosine kinase-mediated pro-survival signaling in a cancer cell
ES2899186T3 (es) 2010-12-31 2022-03-10 Bioatla Inc Humanización rápida de anticuerpos
US20120171195A1 (en) 2011-01-03 2012-07-05 Ravindranath Mepur H Anti-hla-e antibodies, therapeutic immunomodulatory antibodies to human hla-e heavy chain, useful as ivig mimetics and methods of their use
EP2665751A1 (en) 2011-01-19 2013-11-27 Bayer Intellectual Property GmbH Binding proteins to inhibitors of coagulation factors
WO2012101125A1 (en) 2011-01-24 2012-08-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Specific antibodies against human cxcl4 and uses thereof
WO2012103240A2 (en) 2011-01-25 2012-08-02 Eleven Biotherapeutics, Inc. Receptor binding agents
DK2668210T3 (da) 2011-01-26 2020-08-24 Celldex Therapeutics Inc Anti-kit antistoffer og anvendelser deraf
WO2012104824A1 (en) 2011-02-04 2012-08-09 Ecole polytechnique fédérale de Lausanne (EPFL) Therapeutic antibodies targeting app-c99
GB201102189D0 (en) 2011-02-08 2011-03-23 King S College London Materials and methods relating to cardiovascular imaging
US20140044644A1 (en) 2011-02-21 2014-02-13 University Of Zurich Ankyrin g and modulators thereof for the treatment of neurodegenerative disorders
AR085302A1 (es) 2011-02-24 2013-09-18 Sanofi Sa Metodo de produccion de anticuerpos sialilados
EP2679681B2 (en) 2011-02-25 2023-11-15 Chugai Seiyaku Kabushiki Kaisha FcgammaRIIB-specific FC antibody
EP2492279A1 (en) 2011-02-25 2012-08-29 Laboratorios Del. Dr. Esteve, S.A. Rapid immunogen selection method using lentiviral display
WO2012120004A1 (en) 2011-03-07 2012-09-13 F. Hoffmann-La Roche Ag In vivo selection of therapeutically active antibodies
US20140099264A1 (en) 2011-03-07 2014-04-10 F. Hoffman-La Roche Ag Means and methods for in vivo testing of therapeutic antibodies
EP2686014A1 (en) 2011-03-16 2014-01-22 Sanofi Uses of a dual v region antibody-like protein
ES2588730T3 (es) 2011-03-17 2016-11-04 Miltenyi Biotec Gmbh Preparados celulares agotados en lo que respecta a TCRalfa/beta
EP4086338A1 (en) 2011-03-17 2022-11-09 Minerva Biotechnologies Corporation Method for making pluripotent stem cells
SG193545A1 (en) 2011-03-29 2013-11-29 Glaxosmithkline Llc Buffer system for protein purification
WO2012135517A2 (en) 2011-03-29 2012-10-04 Immunogen, Inc. Preparation of maytansinoid antibody conjugates by a one-step process
KR20220009505A (ko) 2011-03-29 2022-01-24 이뮤노젠 아이엔씨 일-단계 방법에 의한 메이탄시노이드 항체 접합체의 제조
DK2698431T3 (da) 2011-03-30 2020-11-30 Chugai Pharmaceutical Co Ltd Opretholdelse af antigen-bindende molekyler i blodplasma og fremgangsmåde til modifikation af immunogenicitet
AU2012237287B2 (en) 2011-03-30 2016-09-08 Ablynx Nv Methods of treating immune disorders with single domain antibodies against TNF-alpha
BR112013025045B1 (pt) 2011-03-31 2020-10-27 INSERM (Institut National de la Santé et de la Recherche Médicale) anticorpos direcionados contra icos e usos dos mesmos
KR20140027211A (ko) 2011-04-04 2014-03-06 유니버시티 오브 아이오와 리써치 파운데이션 백신 면역원성의 개선 방법
CA2832556A1 (en) 2011-04-07 2012-10-11 Glaxosmithkline Llc Formulations with reduced viscosity
US9266960B2 (en) 2011-04-08 2016-02-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-epidermal growth factor receptor variant III chimeric antigen receptors and use of same for the treatment of cancer
US20140193420A1 (en) 2011-04-18 2014-07-10 Chugai Seiyaku Kabushiki Kaisha Diagnosis and treatment of cancer using anti-itm2a antibody
RS57324B1 (sr) 2011-04-20 2018-08-31 Medimmune Llc Antitela i drugi molekuli koji vezuju b7-h1 i pd-1
WO2012151247A2 (en) 2011-05-02 2012-11-08 Millennium Pharmaceuticals, Inc. FORMULATION FOR ANTI-α4β7 ANTIBODY
UA116189C2 (uk) 2011-05-02 2018-02-26 Мілленніум Фармасьютікалз, Інк. КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА
US9598496B2 (en) 2011-05-09 2017-03-21 Perseus Proteomics Inc. Antibody capable of specifically recognizing transferrin receptor
EP2707711A1 (en) 2011-05-09 2014-03-19 The Cleveland Clinic Foundation Serum s100b and uses thereof
ES2643694T3 (es) 2011-05-19 2017-11-23 Inserm (Institut National De La Santé Et De La Recherche Medicale) Anticuerpos anti-HER3 humanos y sus usos
JP6145088B2 (ja) 2011-05-21 2017-06-07 マクロジェニクス，インコーポレーテッド 脱免疫化血清結合ドメイン及び血清半減期を延長するためのその使用
AR086543A1 (es) 2011-05-25 2014-01-08 Bg Medicine Inc Inhibidores de galectina-3 y metodos de uso de los mismos, composicion farmaceutica
EA028220B1 (ru) 2011-05-27 2017-10-31 Глаксо Груп Лимитед Иммуноконъюгат на основе белка, связывающегося с bcma (cd269/tnfrsf17), его медицинское применение и фармацевтическая композиция
EP2530088A1 (en) 2011-05-30 2012-12-05 Klinikum rechts der Isar der Technischen Universität München Means and methods for diagnosing and treating multiple sclerosis
CN103619353B (zh) 2011-06-02 2016-01-06 戴埃克斯有限公司 Fc受体结合蛋白
WO2012168259A1 (en) 2011-06-06 2012-12-13 Novartis Forschungsstiftung, Zweigniederlassung Protein tyrosine phosphatase, non-receptor type 11 (ptpn11) and triple-negative breast cancer
WO2012170742A2 (en) 2011-06-07 2012-12-13 University Of Hawaii Treatment and prevention of cancer with hmgb1 antagonists
WO2012170740A2 (en) 2011-06-07 2012-12-13 University Of Hawaii Biomarker of asbestos exposure and mesothelioma
WO2012168399A1 (en) 2011-06-08 2012-12-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting, treating and modelling hormone resistance
US9346859B2 (en) 2011-06-09 2016-05-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Pseudomonas exotoxin A with less immunogenic T cell and/or B cell epitopes
RS57024B1 (sr) 2011-06-10 2018-05-31 Medimmune Ltd Anti-pseudomonas psl vezujući molekuli i njihova upotreba
GB201109965D0 (en) 2011-06-10 2011-07-27 Cancer Res Inst Royal Materials and methods for treating estrogen receptor alpher(ER) positive cancer
GB201109966D0 (en) 2011-06-10 2011-07-27 Cancer Res Inst Royal Materials and methods for treating pten mutated or deficient cancer
WO2012172449A1 (en) 2011-06-13 2012-12-20 Pfizer Inc. Lactams as beta secretase inhibitors
EP2723376B1 (en) 2011-06-22 2018-12-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-axl antibodies and uses thereof
ES2677367T3 (es) 2011-06-22 2018-08-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Anticuerpos anti-Axl y usos de los mismos
TR201815563T4 (tr) 2011-06-23 2018-11-21 Biogen Int Neuroscience Gmbh Anti-alfa sinüklein bağlayıcı moleküller.
EP2537933A1 (en) 2011-06-24 2012-12-26 Institut National de la Santé et de la Recherche Médicale (INSERM) An IL-15 and IL-15Ralpha sushi domain based immunocytokines
PT2726101T (pt) 2011-06-30 2018-11-21 Genzyme Corp Inibidores da ativação de células t
BR112013032630B1 (pt) 2011-06-30 2022-06-14 Chugai Seiyaku Kabushiki Kaisha Polipeptídeo heterodimerizado compreendendo região fc de igg
EP2543678A1 (en) 2011-07-08 2013-01-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies for the treatment and prevention of thrombosis
EP2543677A1 (en) 2011-07-08 2013-01-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies for the treatment and prevention of thrombosis
EP2543679A1 (en) 2011-07-08 2013-01-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies for the treatment and prevention of thrombosis
DE202011103324U1 (de) 2011-07-12 2012-01-02 Nekonal S.A.R.L. Therapeutische anti-TIRC7 Antikörper für die Verwendung in Immun und anderen Krankheiten
JP2014520847A (ja) 2011-07-13 2014-08-25 アッヴィ・インコーポレイテッド 抗ｉｌ−１３抗体を使用して喘息を治療するための方法および組成物
GB201112056D0 (en) 2011-07-14 2011-08-31 Univ Leuven Kath Antibodies
EP2548891A1 (en) 2011-07-18 2013-01-23 Universiteit Maastricht Human monoclonal antibody against the gamma subunit of the acetylcholine receptor for use in the treatment of rhabdomyosarcoma.
JP6176849B2 (ja) 2011-07-19 2017-08-09 中外製薬株式会社 アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤
WO2013011072A1 (en) 2011-07-20 2013-01-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Carbapenemase and antibacterial treatment
WO2013014149A1 (en) 2011-07-27 2013-01-31 Philogen S.P.A. Il-12 immunoconjugate
US20140308275A1 (en) 2011-07-27 2014-10-16 Inserm (Institut National De La Sante Et De La Recherche Medicale Methods for diagnosing and treating myhre syndrome
WO2013017656A1 (en) 2011-08-02 2013-02-07 Medizinische Universität Wien Antagonists of ribonucleases for treating obesity
KR101980554B1 (ko) 2011-08-04 2019-05-21 도레이 카부시키가이샤 암의 치료 및/또는 예방용 의약 조성물
JP6065592B2 (ja) 2011-08-04 2017-01-25 東レ株式会社 癌の治療及び／又は予防用医薬組成物
DK2740794T3 (en) 2011-08-04 2018-06-14 Toray Industries PHARMACEUTICAL COMPOSITION FOR TREATMENT AND / OR CANCER PREVENTION
EP2739652B1 (en) 2011-08-04 2017-04-05 Medizinische Universität Innsbruck Cahgt1p inhibitors for use in the treatment of candidiasis
JP5925783B2 (ja) 2011-08-12 2016-05-25 国立感染症研究所長 アスペルギルスフミガーツス感染症の検査、予防及び治療のための方法並びに組成物
AU2012296613B2 (en) 2011-08-15 2016-05-12 Amplimmune, Inc. Anti-B7-H4 antibodies and their uses
MX2014001736A (es) 2011-08-17 2014-03-31 Genentech Inc Inhibicion de angiogenesis en tumores refractarios.
EP2749572A4 (en) 2011-08-23 2015-04-01 Chugai Pharmaceutical Co Ltd NEW ANTI-DDR1 ANTIBODY WITH ANTITUMORACTIVITY
US20140234328A1 (en) 2011-09-09 2014-08-21 Amgen Inc. Use of c-met protein for predicting the efficacy of anti-hepatocyte growth factor ("hgf") antibodies in esophageal and gastric cancer patients
UY34317A (es) 2011-09-12 2013-02-28 Genzyme Corp Anticuerpo antireceptor de célula T (alfa)/ß
WO2013039954A1 (en) 2011-09-14 2013-03-21 Sanofi Anti-gitr antibodies
US20140378389A1 (en) 2011-09-15 2014-12-25 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services T cell receptors recognizing hla-a1- or hla-cw7-restricted mage
EP3301110A1 (en) 2011-09-16 2018-04-04 The USA, as represented by The Secretary, Department of Health and Human Services Pseudomonas exotoxin a with less immunogenic b cell epitopes
SG10201703771WA (en) 2011-09-19 2017-06-29 Axon Neuroscience Se Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease
KR101720394B1 (ko) 2011-09-21 2017-03-27 후지레비오 가부시키가이샤 친화성 복합체에 대한 항체
EP2758438A1 (en) 2011-09-23 2014-07-30 Amgen Research (Munich) GmbH Bispecific binding molecules for 5t4 and cd3
CA2849705A1 (en) 2011-09-23 2013-03-28 Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa Modified albumin-binding domains and uses thereof to improve pharmacokinetics
KR102239138B1 (ko) 2011-09-30 2021-04-12 추가이 세이야쿠 가부시키가이샤 표적 항원에 대한 면역응답을 유도하는 항원 결합 분자
WO2013046722A1 (ja) 2011-09-30 2013-04-04 中外製薬株式会社 イオン濃度依存性結合分子ライブラリ
KR102143331B1 (ko) 2011-09-30 2020-08-11 추가이 세이야쿠 가부시키가이샤 항원의 소실을 촉진시키는 항원 결합 분자
TW201817745A (zh) 2011-09-30 2018-05-16 日商中外製藥股份有限公司 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子
US20150050269A1 (en) 2011-09-30 2015-02-19 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities
EP2764118A1 (en) 2011-10-05 2014-08-13 University of Bremen Wnt4 and med12 for use in the diagnosis and treatment of tumor diseases
JP6271251B2 (ja) 2011-10-05 2018-01-31 中外製薬株式会社 糖鎖受容体結合ドメインを含む抗原の血漿中からの消失を促進する抗原結合分子
WO2013052933A2 (en) 2011-10-06 2013-04-11 The Board Of Trustees Of The University Of Illinois Myosin binding protein-c for use in methods relating to diastolic heart failure
RU2014117510A (ru) 2011-10-10 2015-11-20 Медиммьюн Лимитед Лечение ревматоидного артрита
WO2013055911A1 (en) 2011-10-14 2013-04-18 Dana-Farber Cancer Institute, Inc. Znf365/zfp365 biomarker predictive of anti-cancer response
AU2012326137B2 (en) 2011-10-17 2018-11-29 Minerva Biotechnologies Corporation Media for stem cell proliferation and induction
JP6267644B2 (ja) 2011-10-20 2018-01-24 アメリカ合衆国 抗ｃｄ２２キメラ抗原受容体
CA2852021C (en) 2011-10-21 2018-08-28 Pfizer Inc. Addition of iron to improve cell culture
BR112014009536A2 (pt) 2011-10-21 2017-04-18 Augurex Life Sciences Corp antígenos derivados de 14-3-3 xitrulinada e usos dos mesmos no diagnóstico de artrite reumatoide
EP2771360A1 (en) 2011-10-24 2014-09-03 AbbVie Inc. Immunobinders directed against sclerostin
WO2013063419A2 (en) 2011-10-28 2013-05-02 The Trustees Of The University Of Pennsylvania A fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting
RU2681885C2 (ru) 2011-10-31 2019-03-13 Чугаи Сейяку Кабусики Кайся Антигенсвязывающая молекула с регулируемой конъюгацией между тяжелой цепью и легкой цепью
WO2013067055A1 (en) 2011-11-01 2013-05-10 Bionomics, Inc. Methods of blocking cancer stem cell growth
EP2773664A1 (en) 2011-11-01 2014-09-10 Bionomics, Inc. Anti-gpr49 antibodies
US9221907B2 (en) 2011-11-01 2015-12-29 Bionomics Inc. Anti-GPR49 monoclonal antibodies
WO2013067054A1 (en) 2011-11-01 2013-05-10 Bionomics, Inc. Antibodies and methods of treating cancer
WO2013067492A1 (en) 2011-11-03 2013-05-10 The Trustees Of The University Of Pennsylvania Isolated b7-h4 specific compositions and methods of use thereof
US20140314787A1 (en) 2011-11-08 2014-10-23 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute Treatment for neurodegenerative diseases
WO2013068432A1 (en) 2011-11-08 2013-05-16 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research Early diagnostic of neurodegenerative diseases
WO2013070468A1 (en) 2011-11-08 2013-05-16 The Trustees Of The University Of Pennsylvania Glypican-3-specific antibody and uses thereof
EP2776565A1 (en) 2011-11-08 2014-09-17 Quark Pharmaceuticals, Inc. Methods and compositions for treating diseases, disorders or injury of the nervous system
TWI679212B (zh) 2011-11-15 2019-12-11 美商安進股份有限公司 針對ｂｃｍａ之e3以及ｃｄ３的結合分子
WO2013078455A2 (en) 2011-11-23 2013-05-30 The Board Of Regents Of The University Of Texas System Proteomic identification of antibodies
EP2599496A1 (en) 2011-11-30 2013-06-05 Kenta Biotech AG Novel targets of Acinetobacter baumannii
CN104080909A (zh) 2011-11-30 2014-10-01 中外制药株式会社 包含进入细胞内以形成免疫复合体的搬运体(载体)的药物
CN107353342B (zh) 2011-12-05 2021-08-10 X 博迪生物科学公司 PDGF受体β结合多肽
EP2602621A1 (en) 2011-12-08 2013-06-12 Julius-Maximilians-Universität Würzburg LASP-1, a novel urinary marker for transitional cell carcinoma detection
CN104302324A (zh) 2011-12-08 2015-01-21 生物测试股份公司 靶向cd138的免疫偶联物的用途
GB201121301D0 (en) 2011-12-12 2012-01-25 Novartis Ag Method
GB201121564D0 (en) 2011-12-14 2012-01-25 Queen Mary & Westfield College Use of antibody
US20150030602A1 (en) 2011-12-23 2015-01-29 Phenoquest Ag Antibodies for the treatment and diagnosis of affective and anxiety disorders
WO2013093809A1 (en) 2011-12-23 2013-06-27 Pfizer Inc. Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
TWI593705B (zh) 2011-12-28 2017-08-01 Chugai Pharmaceutical Co Ltd Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient
SI2797952T1 (sl) 2011-12-28 2019-07-31 Immunoqure Ag Postopek za pripravo monoklonskih avto-protiteles z želeno specifičnostjo
MX2014008101A (es) 2011-12-30 2014-09-25 Abbvie Inc Proteinas de union especificas duales dirigidas contra il-13 y/o il-17.
EP2800583A1 (en) 2012-01-02 2014-11-12 Novartis AG Cdcp1 and breast cancer
CA2862999A1 (en) 2012-01-11 2013-07-18 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University Bispecific antibody fragments for neurological disease proteins and methods of use
US20130177574A1 (en) 2012-01-11 2013-07-11 Paul I. Terasaki Foundation Laboratory ANTI-HLA CLASS-Ib ANTIBODIES MIMIC IMMUNOREACTIVITY AND IMMUNOMODULATORY FUNCTIONS OF INTRAVENOUS IMMUNOGLOBULIN (IVIg) USEFUL AS THERAPEUTIC IVIg MIMETICS AND METHODS OF THEIR USE
US10800847B2 (en) 2012-01-11 2020-10-13 Dr. Mepur Ravindranath Anti-HLA class-IB antibodies mimic immunoreactivity and immunomodulatory functions of intravenous immunoglobulin (IVIG) useful as therapeutic IVIG mimetics and methods of their use
LT2804878T (lt) 2012-01-20 2018-12-10 Genzyme Corporation Anti-cxcr3 antikūnai
NZ714482A (en) 2012-01-27 2017-08-25 Abbvie Inc Composition and method for diagnosis and treatment of diseases associated with neurite degeneration
SG10201704849PA (en) 2012-02-09 2017-07-28 Chugai Pharmaceutical Co Ltd Modified fc region of antibody
EP2812702B1 (en) 2012-02-10 2019-04-17 Seattle Genetics, Inc. Diagnosis and management of CD30-expressing cancers
EP3196214B1 (en) 2012-02-15 2019-07-31 Novo Nordisk A/S Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (trem-1)
EP2814842B1 (en) 2012-02-15 2018-08-22 Novo Nordisk A/S Antibodies that bind peptidoglycan recognition protein 1
US9550830B2 (en) 2012-02-15 2017-01-24 Novo Nordisk A/S Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
MX370199B (es) 2012-02-16 2019-12-05 Santarus Inc Composiciones farmaceuticas de anticuerpo anti-antigeno muy tardio (cd49a).
BR112014021103A2 (ja) 2012-02-21 2019-10-15 Toray Industries, Inc The medical treatment and/or the medicine constituent for prevention of cancer
PL2818483T3 (pl) 2012-02-21 2018-01-31 Toray Industries Kompozycja lecznicza do leczenia i/lub zapobiegania nowotworowi
EP2818482B1 (en) 2012-02-21 2019-05-22 Toray Industries, Inc. Pharmaceutical composition for treatment of cancer
MX363136B (es) 2012-02-21 2019-03-12 Toray Industries Composicion farmaceutica para el tratamiento y/o prevencion del cancer.
ES2842201T3 (es) 2012-02-23 2021-07-13 Daiichi Sankyo Europe Gmbh Inhibidor de HER3 para modulación de radiosensibilidad
ES2795419T3 (es) 2012-02-24 2020-11-23 Chugai Pharmaceutical Co Ltd Molécula de unión al antígeno que promueve la desaparición del antígeno vía Fc RIIB
AU2013224919B2 (en) 2012-03-01 2017-12-07 Amgen Research (Munich) Gmbh Long life polypeptide binding molecules
RS58910B1 (sr) 2012-03-20 2019-08-30 Biogen Ma Inc Antitela koja neutrališu virus jcv
CA3209571A1 (en) 2012-03-23 2013-09-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-mesothelin chimeric antigen receptors
US9592289B2 (en) 2012-03-26 2017-03-14 Sanofi Stable IgG4 based binding agent formulations
WO2013142901A1 (en) 2012-03-26 2013-10-03 Commonwealth Scientific And Industrial Research Organisation Silk polypeptides
EP2831113B1 (en) 2012-03-28 2018-03-14 Sanofi Antibodies to bradykinin b1 receptor ligands
US20150266961A1 (en) 2012-03-29 2015-09-24 Novartis Forschungsstiftung, Zweigniederlassung, Fridrich Miescher Institute Inhibition of interleukin-8 and/or its receptor cxcr1 in the treatment of her2/her3-overexpressing breast cancer
US9751942B2 (en) 2012-03-29 2017-09-05 Chugai Seiyaku Kabushiki Kaisha Anti-LAMP5 antibody and utilization thereof
KR102052400B1 (ko) 2012-03-30 2019-12-06 도레이 카부시키가이샤 담낭암의 치료 및/또는 예방용 의약 조성물
HUE036424T2 (hu) 2012-03-30 2018-07-30 Toray Industries Gyógyászati készítmény májrák kezelésére és/vagy megelõzésére
CN103382223B (zh) 2012-04-01 2015-06-10 上海益杰生物技术有限公司 针对表皮生长因子受体隐蔽表位和t细胞抗原的多功能抗体多肽
EP2834641A1 (en) 2012-04-02 2015-02-11 Gundersen Lutheran Health Systems, Inc. Reagents, methods, and kits for the classification of cancer
WO2013151649A1 (en) 2012-04-04 2013-10-10 Sialix Inc Glycan-interacting compounds
WO2013150623A1 (ja) 2012-04-04 2013-10-10 株式会社ペルセウスプロテオミクス 抗ｃｄｈ３（ｐ－カドヘリン）抗体の薬剤コンジュゲート
WO2013153083A1 (en) 2012-04-11 2013-10-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for diagnosing a skeletal ciliopathy
EP2660324A1 (en) 2012-05-02 2013-11-06 Algenics Production of secreted therapeutic antibodies in microalgae
US9980942B2 (en) 2012-05-02 2018-05-29 Children's Hospital Medical Center Rejuvenation of precursor cells
US20150112045A1 (en) 2012-05-02 2015-04-23 Algenics Production of secreted therapeutic antibodies in microalgae
EP2660323A1 (en) 2012-05-02 2013-11-06 Algenics Production of secreted therapeutic antibodies in phaeodactylum tricornutum microalgae
WO2013166290A1 (en) 2012-05-04 2013-11-07 Abbvie Biotherapeutics Inc. P21 biomarker assay
JP2013235003A (ja) 2012-05-10 2013-11-21 Fujita Gakuen 細胞におけるｄｎａ損傷の検出方法及びｄｎａ鎖切断応答性細胞表面抗原に対する抗体
EP2848633B1 (en) 2012-05-11 2019-02-06 Microbial Chemistry Research Foundation Anti-cxadr antibody
NZ702178A (en) 2012-05-14 2017-01-27 Biogen Ma Inc Lingo-2 antagonists for treatment of conditions involving motor neurons
EP2849786B1 (en) 2012-05-15 2019-11-06 Eisai Inc. Methods for treatment of gastric cancer
US20150133381A1 (en) 2012-05-16 2015-05-14 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for the diagnosis and the treatment of familial thoracic aortic aneurysms caused by tgfb2 loss of function mutations
BR112014028684A2 (pt) 2012-05-18 2017-07-25 Univ Pennsylvania subfamília e adenovírus de símio a1302, a1320, a1331 e a1337 e usos dos mesmos
EP3527584B8 (en) 2012-05-22 2020-12-16 The United States of America, as represented by the Secretary, Department of Health and Human Services Medical use of cells comprising anti-ny-eso-1 t cell receptors
WO2013175276A1 (en) 2012-05-23 2013-11-28 Argen-X B.V Il-6 binding molecules
WO2013177386A1 (en) 2012-05-24 2013-11-28 Abbvie Biotherapeutics Inc. Biomarkers for predicting response to tweak receptor (tweakr) agonist therapy
EP2855529A4 (en) 2012-05-24 2015-12-09 Alexion Pharma Inc HUMANIZED ANTI-FACTOR B ANTIBODIES
ES2856272T3 (es) 2012-05-30 2021-09-27 Chugai Pharmaceutical Co Ltd Molécula de unión a antígenos para eliminar antígenos agregados
JPWO2013180200A1 (ja) 2012-05-30 2016-01-21 中外製薬株式会社 標的組織特異的抗原結合分子
EP4310191A3 (en) 2012-06-14 2024-05-15 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule containing modified fc region
US9676847B2 (en) 2012-06-25 2017-06-13 Orega Biotech IL-17 antagonist antibodies
WO2014001482A1 (en) 2012-06-29 2014-01-03 Novartis Forschungsstiftung, Zweigniererlassung, Friedrich Miescher Institute For Biomedical Research Treating diseases by modulating a specific isoform of mkl1
US20150184154A1 (en) 2012-07-05 2015-07-02 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Resear New treatment for neurodegenerative diseases
US10656156B2 (en) 2012-07-05 2020-05-19 Mepur Ravindranath Diagnostic and therapeutic potential of HLA-E monospecific monoclonal IgG antibodies directed against tumor cell surface and soluble HLA-E
EP2870177A1 (en) 2012-07-05 2015-05-13 Glaxo Group Limited Optimum dose regime of an anti-nogo-a antibody in the treatment of amyotrophic lateral sclerosis
WO2014006115A1 (en) 2012-07-06 2014-01-09 Novartis Ag Combination of a phosphoinositide 3-kinase inhibitor and an inhibitor of the il-8/cxcr interaction
AR091755A1 (es) 2012-07-12 2015-02-25 Abbvie Inc Proteinas de union a il-1
EP3730512A1 (en) 2012-07-13 2020-10-28 The Trustees of the University of Pennsylvania Enhancing activity of car t cells by co-introducing a bispecific antibody
KR20180088926A (ko) 2012-07-24 2018-08-07 파마싸이클릭스 엘엘씨 브루톤 티로신 키나제(btk)의 억제제에 대한 내성과 관련된 돌연변이
US9334332B2 (en) 2012-07-25 2016-05-10 Kolltan Pharmaceuticals, Inc. Anti-kit antibodies
EA029563B1 (ru) 2012-07-27 2018-04-30 Арагон Фармасьютикалз, Инк. Способы и композиции для определения резистентности к терапии, направленной на андрогенный рецептор
WO2014020293A1 (en) 2012-07-31 2014-02-06 Imperial Innovations Limited Assay
HUE048780T2 (hu) 2012-08-16 2020-09-28 Ipierian Inc Tauopátia kezelésére szolgáló módszerek
EP2698377A1 (en) 2012-08-17 2014-02-19 Laboratorios Del. Dr. Esteve, S.A. Enhanced rapid immunogen selection method for HIV gp120 variants
JP6774164B2 (ja) 2012-08-24 2020-10-21 中外製薬株式会社 マウスＦｃγＲＩＩ特異的Ｆｃ抗体
US10919953B2 (en) 2012-08-24 2021-02-16 Chugai Seiyaku Kabushiki Kaisha FcgammaRIIB-specific Fc region variant
ES2684552T3 (es) 2012-09-03 2018-10-03 Inserm - Institut National De La Santé Et De La Recherche Médicale Anticuerpos dirigidos contra ICOS para tratar la enfermedad de injerto contra hospedador
EP3636665B1 (en) 2012-09-14 2022-06-29 The United States of America, as represented by The Secretary, Department of Health and Human Services T cell receptors recognizing mhc class ii-restricted mage-a3
EP2711016A1 (en) 2012-09-21 2014-03-26 Covagen AG Novel IL-17A binding molecules and medical uses thereof
WO2014049520A2 (en) 2012-09-25 2014-04-03 Fujita Health University Novel epitope and mechanism of antigen-antibody interaction in an influenza virus
AU2013320972B2 (en) 2012-09-27 2018-08-30 Chugai Seiyaku Kabushiki Kaisha FGFR3 fusion gene and pharmaceutical drug targeting same
TWI609083B (zh) 2012-09-28 2017-12-21 Chugai Pharmaceutical Co Ltd Blood coagulation reaction assessment method
EP2904106A4 (en) 2012-10-01 2016-05-11 Univ Pennsylvania COMPOSITIONS AND METHODS FOR TARGETING STROMAL CELLS FOR THE TREATMENT OF CANCER
NO2760138T3 (ja) 2012-10-01 2018-08-04
SG11201502404WA (en) 2012-10-03 2015-05-28 Philogen Spa Antigens associated with inflammatory bowel disease
US10035817B2 (en) 2012-10-04 2018-07-31 Immunogen, Inc. Method of purifying cell-binding agent-cytotoxic agent conjugates with a PVDF membrane
US9598489B2 (en) 2012-10-05 2017-03-21 The Trustees Of The Univeristy Of Pennsylvania Human alpha-folate receptor chimeric antigen receptor
EP3677310A1 (en) 2012-10-08 2020-07-08 St. Jude Children's Research Hospital Therapies based on control of regulatory t cell stability and function via a neuropilin-1:semaphorin axis
AU2013329421A1 (en) 2012-10-09 2015-04-30 Biogen Ma Inc. Combination therapies and uses for treatment of demyelinating disorders
RU2689674C2 (ru) 2012-10-15 2019-05-28 Медиммьюн Лимитед Антитела к бета-амилоиду
DE102012020496A1 (de) 2012-10-18 2014-04-24 Charité - Universitätsmedizin Berlin Biomarker zur Diagnostik und Behandlung von Neurofibromatose Typ 1
RU2658485C2 (ru) 2012-10-24 2018-06-21 Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез Химерные антигенные рецепторы м971
WO2014066744A2 (en) 2012-10-25 2014-05-01 True North Therapeutics, Inc. Anti-complement c1s antibodies and uses thereof
TW201811825A (zh) 2012-11-01 2018-04-01 美商艾伯維有限公司 抗-ｖｅｇｆ／ｄｌｌ４雙重可變區域免疫球蛋白及其用途
US8945562B2 (en) 2012-11-02 2015-02-03 True North Therapeutics, Inc. Anti-complement C1s antibodies
CN105377288B (zh) 2012-11-05 2019-11-15 达纳-法伯癌症研究所股份有限公司 Xbp1、cd138和cs1肽的组合物制备药物的用途
JP6212497B2 (ja) 2012-11-08 2017-10-11 国立大学法人 宮崎大学 トランスフェリン受容体を特異的に認識できる抗体
WO2014074218A1 (en) 2012-11-12 2014-05-15 Redwood Bioscience, Inc. Compounds and methods for producing a conjugate
EP2733153A1 (en) 2012-11-15 2014-05-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the preparation of immunoconjugates and uses thereof
US9310374B2 (en) 2012-11-16 2016-04-12 Redwood Bioscience, Inc. Hydrazinyl-indole compounds and methods for producing a conjugate
EP2920148B1 (en) 2012-11-16 2019-06-12 The Regents of the University of California Pictet-spengler ligation for protein chemical modification
KR102408660B1 (ko) 2012-11-20 2022-06-15 사노피 항-ceacam5 항체 및 이의 용도
US20140154255A1 (en) 2012-11-30 2014-06-05 Abbvie Biotherapeutics Inc. Anti-vegf antibodies and their uses
EP2925779A1 (en) 2012-11-30 2015-10-07 Institut Pasteur Use of anti-fcyri and/or anti-fcyriia antibodies for treating arthritis, inflammation, thrombocytopenia and allergic shock
UA118255C2 (uk) 2012-12-07 2018-12-26 Санофі Композиція, яка містить антитіло до cd38 і леналідомід
US10342869B2 (en) 2012-12-07 2019-07-09 The Regents Of The University Of California Compositions comprising anti-CD38 antibodies and lenalidomide
MX2015007846A (es) 2012-12-19 2016-04-28 Amplimmune Inc Anticuerpos anti-b7-h4 humana y sus usos.
US10024844B2 (en) 2012-12-20 2018-07-17 Hospital For Special Surgery Identification of an inhibitor of iRhom1 or an inhibitor of iRhom2
GB201223172D0 (en) 2012-12-21 2013-02-06 Immunocore Ltd Method
MX2015008117A (es) 2012-12-21 2016-03-31 Amplimmune Inc Anticuerpos anti-h7cr.
LT2935326T (lt) 2012-12-21 2020-12-10 Biogen Ma Inc. Žmogaus antikūnai prieš tau baltymą
WO2014100542A1 (en) 2012-12-21 2014-06-26 Abbvie, Inc. High-throughput antibody humanization
EP2940135B9 (en) 2012-12-27 2021-09-08 Chugai Seiyaku Kabushiki Kaisha Heterodimerized polypeptide
JP6441232B2 (ja) 2012-12-27 2018-12-19 サノフイＳａｎｏｆｉ 抗ｌａｍｐ１抗体および抗体薬物コンジュゲート、ならびにその使用
CA2896824A1 (en) 2012-12-31 2014-07-03 Neurimmune Holding Ag Recombinant human antibodies for therapy and prevention of polyomavirus-related diseases
EP2752426A1 (en) 2013-01-03 2014-07-09 Covagen AG Human serum albumin binding compounds and fusion proteins thereof
CA2897914A1 (en) 2013-01-28 2014-07-31 Evec Inc. Humanized anti-hmgb1 antibody or antigen-binding fragment thereof
EP2951199A4 (en) 2013-01-31 2016-07-20 Univ Jefferson Fusion proteins for the modulation of regulatory and effector T cells
EP2955226B1 (en) 2013-02-08 2019-06-26 Medical & Biological Laboratories Co., Ltd. Antibodies to human nrg1 protein
US9644028B2 (en) 2013-02-15 2017-05-09 Perseus Proteomics Inc. Anti-CDH3 humanized antibody, drug conjugate thereof, and use thereof
PL2958943T3 (pl) 2013-02-20 2020-04-30 The Trustees Of The University Of Pennsylvania Leczenie nowotworu złośliwego za pomocą humanizowanego chimerycznego receptora antygenowego anty-egfrviii
US9573988B2 (en) 2013-02-20 2017-02-21 Novartis Ag Effective targeting of primary human leukemia using anti-CD123 chimeric antigen receptor engineered T cells
ES2673583T3 (es) 2013-02-28 2018-06-22 National Cancer Center Anticuerpo contra fibrina insoluble
CN105407921A (zh) 2013-03-13 2016-03-16 赛诺菲 包含抗cd38抗体和卡非佐米的组合物
US9023353B2 (en) 2013-03-13 2015-05-05 The Board Of Trustees Of The University Of Arkansas Anti-(+)—methamphetamine monoclonal antibodies
US20140308239A1 (en) 2013-03-13 2014-10-16 Eleven Biotherapeutics, Inc. Chimeric cytokine formulations for ocular delivery
CA2906407A1 (en) 2013-03-14 2014-09-18 Abbott Laboratories Hcv ns3 recombinant antigens and mutants thereof for improved antibody detection
MX362075B (es) 2013-03-14 2019-01-07 Abbott Lab Ensayo de combinación de antígeno-anticuerpo del virus de la hepatitis c (vhc) y métodos y composiciones para usarlo.
JP6739329B2 (ja) 2013-03-14 2020-08-12 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ Ｈｃｖコア脂質結合ドメインモノクローナル抗体
WO2014144466A1 (en) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Anti-alpha v beta 6 antibodies and uses thereof
WO2014145252A2 (en) 2013-03-15 2014-09-18 Milone Michael C Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
CA2903576C (en) 2013-03-15 2021-06-08 Nai-Kong V. Cheung High affinity anti-gd2 antibodies
JP6449229B2 (ja) 2013-03-15 2019-01-09 アッヴィ・バイオセラピューティクス・インコーポレイテッド Ｆｃ変異体
TW201512219A (zh) 2013-03-15 2015-04-01 Abbvie Inc 針對ＩＬ－１β及／或ＩＬ－１７之雙特異性結合蛋白
NZ711355A (en) 2013-03-15 2020-06-26 Glaxosmithkline Ip Dev Ltd Anti-lag-3 binding proteins
WO2014141149A1 (en) 2013-03-15 2014-09-18 Glaxosmithkline Intellectual Property (No.2) Limited Formulations with reduced viscosity
US9446105B2 (en) 2013-03-15 2016-09-20 The Trustees Of The University Of Pennsylvania Chimeric antigen receptor specific for folate receptor β
CA2904527A1 (en) 2013-03-15 2014-09-18 Abbvie Biotechnology Ltd. Anti-cd25 antibodies and their uses
WO2014143739A2 (en) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Anti-alpha v beta 6 antibodies and uses thereof
CA2902905A1 (en) 2013-03-15 2014-09-25 Claude Geoffrey Davis Modified toxins
CA2902288A1 (en) 2013-03-15 2014-09-18 Glaxosmithkline Intellectual Property (No.2) Limited Use of tricarboxylic acid (tca) intermediates to control ammonia generation in cell culture
EP3686217A1 (en) 2013-03-15 2020-07-29 GlaxoSmithKline Intellectual Property (No.2) Limited Low concentration antibody formulations
WO2014141150A1 (en) 2013-03-15 2014-09-18 Glaxosmithkline Intellectual Property (No.2) Limited Methods for purifying antibodies
AR095374A1 (es) 2013-03-15 2015-10-14 Amgen Res (Munich) Gmbh Moléculas de unión para bcma y cd3
AR095199A1 (es) 2013-03-15 2015-09-30 Genzyme Corp Anticuerpos anti-cd52
US20150010539A1 (en) 2013-03-15 2015-01-08 Abbvie Biotherapeutics Inc. Anti-cd25 antibodies and their uses
UY35468A (es) 2013-03-16 2014-10-31 Novartis Ag Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
WO2014160627A1 (en) 2013-03-25 2014-10-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-cd276 polypeptides, proteins, and chimeric antigen receptors
CN113621057A (zh) 2013-04-02 2021-11-09 中外制药株式会社 Fc区变体
CA2909576C (en) 2013-04-19 2023-07-18 Cytune Pharma Cytokine derived treatment with reduced vascular leak syndrome
WO2014174596A1 (ja) 2013-04-23 2014-10-30 株式会社医学生物学研究所 ヘパリン結合上皮増殖因子様増殖因子に対する機能性モノクローナル抗体
KR102190322B1 (ko) 2013-04-29 2020-12-11 오제데2 파르마 암줄기세포 암에 대한 새로운 치료적 진단적 전략으로서 o-아세틸화된-gd2 갱글리오사이드 타겟화
TWI679019B (zh) 2013-04-29 2019-12-11 法商賽諾菲公司 抗ｉｌ－４／抗ｉｌ－１３之雙特異性抗體調配物
US10745489B2 (en) 2013-04-29 2020-08-18 Ogd2 Pharma Targeting o-acetylated gd2 ganglioside as a new therapeutic and diagnostic strategy for Cancer Stem Cells cancer
IL301607A (en) 2013-05-06 2023-05-01 Scholar Rock Inc Preparations and methods for growth factor modulation
GB201308259D0 (en) 2013-05-08 2013-06-12 Iles Raymond K Cancer diagnosis and monitoring
CN104140974B (zh) 2013-05-08 2017-09-29 科济生物医药（上海）有限公司 编码gpc‑3嵌合抗原受体蛋白的核酸及表达gpc‑3嵌合抗原受体蛋白的t淋巴细胞
JP6537143B2 (ja) 2013-05-16 2019-07-03 国立大学法人京都大学 癌の予後を診断する方法
US10005839B2 (en) 2013-05-17 2018-06-26 Inserm (Institut National De La Sante Et De La Recherche Medicale) Antagonist of the BTLA/HVEM interaction for use in therapy
SG10201709715RA (en) 2013-05-24 2017-12-28 Medimmune Llc Anti-b7-h5 antibodies and their uses
CA2914369C (en) 2013-06-06 2023-02-14 Igenica Biotherapeutics, Inc. Anti-c10orf54 antibodies and uses thereof
EA039554B1 (ru) 2013-06-10 2022-02-09 АйПИЕРИАН, ИНК. Способ снижения уровней a40 и/или a42 в нервной клетке и/или во внеклеточной жидкости
JP6442404B2 (ja) 2013-06-11 2018-12-19 国立研究開発法人国立精神・神経医療研究センター 再発寛解型多発性硬化症（ｒｒｍｓ）患者の治療予後予測方法、及び新規治療適応判断方法
US9499628B2 (en) 2013-06-14 2016-11-22 Children's Hospital Medical Center Method of boosting the immune response in neonates
EP3159695A3 (en) 2013-06-20 2017-07-05 The Trustees of The University of Pennsylvania Methods for diagnosing pancreatic cancer
US9890369B2 (en) 2013-06-20 2018-02-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cytolethal distending toxin subunit B conjugated or fused to Bacillus anthracis toxin lethal factor
AU2014299916A1 (en) 2013-06-24 2015-12-24 Chugai Seiyaku Kabushiki Kaisha Therapeutic agent comprising humanized anti-Epiregulin antibody as active ingredient for non-small-cell lung carcinoma excluding adenocarcinoma
WO2015001013A2 (en) 2013-07-03 2015-01-08 Immunoqure Ag Human anti-ifn-alpha antibodies
EP2824176A1 (en) 2013-07-11 2015-01-14 Siamed'xpress Methods for producing sialylated therapeutic proteins
JP6628719B2 (ja) 2013-07-15 2020-01-15 アメリカ合衆国 抗ヒトパピローマウイルス１６ ｅ６ ｔ細胞受容体
US10208125B2 (en) 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
ES2761587T3 (es) 2013-08-07 2020-05-20 Friedrich Miescher Institute For Biomedical Res Nuevo método de cribado para el tratamiento de la ataxia de Friedreich
MX2016001555A (es) 2013-08-08 2016-08-03 Cytune Pharma Modulocinas basadas en dominio sushi de interleucina-15 (il-15) y receptor alfa de interleucina-15 (il-15ra).
EP3030262B1 (en) 2013-08-08 2019-10-09 Cytune Pharma Combined pharmaceutical composition
CN105452294B (zh) 2013-08-09 2019-08-02 东丽株式会社 癌的治疗和/或预防用药物组合物
MX2016001854A (es) 2013-08-12 2016-09-06 Genentech Inc Composiciones y metodo para tratar condiciones asociadas con el complemento.
CR20190319A (es) 2013-08-13 2019-08-29 Sanofi Sa ANTICUERPOS CONTRA EL INHIBIDOR DEL ACTIVADOR DE PLASMINÓGENO TIPO 1 (PAI-1) Y USOS DE LOS MISMOS (Divisional 2016-0117)
TWI592426B (zh) 2013-08-13 2017-07-21 賽諾菲公司 胞漿素原活化素抑制劑－１（ｐａｉ－１）之抗體及其用途
WO2015033831A1 (ja) 2013-09-04 2015-03-12 国立大学法人 大阪大学 Ｄｐｐ－４を標的とした糖尿病治療用ワクチン
WO2015035044A2 (en) 2013-09-04 2015-03-12 Abbvie Biotherapeutics Inc. Fc VARIANTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY
US9481729B2 (en) 2013-09-11 2016-11-01 The University Of Hong Kong Anti-HER2 and anti-IGF-IR BI-specific antibodies and uses thereof
CA2924020A1 (en) 2013-09-20 2015-03-26 Westfaelische Wilhelms-Universitaet Muenster Cell-penetrating bacterial e3-ubiqitin-ligases for use in immunotherapy
WO2015041310A1 (ja) 2013-09-20 2015-03-26 中外製薬株式会社 抗プロテインｃ抗体による出血性疾患の治療
US9957295B2 (en) 2013-09-24 2018-05-01 The Feinstein Institute For Medical Research Peptides inhibiting cold-inducible RNA binding protein activity
ES2894333T3 (es) 2013-09-26 2022-02-14 Beth Israel Deaconess Medical Ct Inc Inhibidores de SGK1 en el tratamiento del síndrome de QT Largo
EP3050896B1 (en) 2013-09-27 2021-07-07 Chugai Seiyaku Kabushiki Kaisha Method for producing polypeptide heteromultimer
AU2014329437B2 (en) 2013-10-06 2018-10-18 F. Hoffmann-La Roche Ag Modified Pseudomonas exotoxin A
EP3063317B1 (en) 2013-10-28 2020-06-03 DOTS Technology Corp. Allergen detection
TW201522378A (zh) 2013-10-31 2015-06-16 Sanofi Sa 用於治療人類癌症的特異性抗ｃｄ３８抗體
GB201319374D0 (en) 2013-11-01 2013-12-18 Univ Nottingham Glycans as functional cancer targets abd antibodies thereto
US20160264648A1 (en) 2013-11-06 2016-09-15 Osaka University Antibody having broad neutralization activity against group 1 influenza a viruses
CA2929386C (en) 2013-11-07 2023-01-03 Inserm (Institut National De La Sante Et De La Recherche Medicale) Neuregulin allosteric anti-her3 antibody
EP2871190A1 (en) 2013-11-11 2015-05-13 ATLAB Pharma Antibody against GD2-O-acetylated ganglioside with pro-apoptotic activity
CN113307873A (zh) 2013-11-11 2021-08-27 中外制药株式会社 含有改变了抗体可变区的抗原结合分子
JP6633520B2 (ja) 2013-11-12 2020-01-22 オージーディー２ ファーマ プロアポトーシス活性を有するヒトｉｇｇ１由来抗体
GB201320061D0 (en) 2013-11-13 2013-12-25 Electrophoretics Ltd Materials nad methods for diagnosis and prognosis of liver cancer
EP2873740A1 (en) 2013-11-19 2015-05-20 Oncodiag Methods for the surveillance, diagnosis and screening of bladder cancer
CA2931396C (en) 2013-11-27 2022-09-06 Ipierian, Inc. An anti-tau antibody for treating tauopothy
JP6745218B2 (ja) 2013-11-27 2020-08-26 レッドウッド バイオサイエンス， インコーポレイテッド ヒドラジニル−ピロロ化合物及び複合体を生成するための方法
AU2014358191B2 (en) 2013-12-04 2020-12-24 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecules, the antigen-binding activity of which varies according to the concentration of compounds, and libraries of said molecules
CA2932424C (en) 2013-12-06 2023-10-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thymic stromal lymphopoietin receptor-specific chimeric antigen receptors and methods using same
CA2932819A1 (en) 2013-12-09 2015-06-18 New York University Compositions and methods for phagocyte delivery of anti-staphylococcal agents
WO2015088346A1 (en) 2013-12-13 2015-06-18 Rijksuniversiteit Groningen Antibodies against staphylococcus aureus and uses thereof.
US8980273B1 (en) 2014-07-15 2015-03-17 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
US8986691B1 (en) 2014-07-15 2015-03-24 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
WO2015090229A1 (en) 2013-12-20 2015-06-25 Novartis Ag Regulatable chimeric antigen receptor
US11421025B2 (en) 2013-12-27 2022-08-23 Osaka University Treatment of IL-17A diseases
JP6722455B2 (ja) 2013-12-27 2020-07-15 中外製薬株式会社 等電点の低い抗体の精製方法
TW201609093A (zh) 2013-12-27 2016-03-16 Chugai Pharmaceutical Co Ltd Ｆｇｆｒ門控蛋白變異基因及以其爲標的之醫藥
CA2936346A1 (en) 2014-01-08 2015-07-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibody targeting cell surface deposited complement protein c3d and use thereof
EP2893939A1 (en) 2014-01-10 2015-07-15 Netris Pharma Anti-netrin-1 antibody
US10286058B2 (en) 2014-01-13 2019-05-14 Baylor Research Institute Vaccines against HPV and HPV-related diseases
CN104774264B (zh) 2014-01-15 2018-09-14 上海易乐生物技术有限公司 抗人proBDNF单克隆抗体及其在疼痛中的作用
US11028143B2 (en) 2014-01-21 2021-06-08 Novartis Ag Enhanced antigen presenting ability of RNA CAR T cells by co-introduction of costimulatory molecules
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
CA2936984A1 (en) 2014-01-24 2015-07-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-ny-br-1 polypeptides, proteins, and chimeric antigen receptors
JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
US11648335B2 (en) 2014-01-31 2023-05-16 Wake Forest University Health Sciences Organ/tissue decellularization, framework maintenance and recellularization
WO2015120187A1 (en) 2014-02-05 2015-08-13 The University Of Chicago Chimeric antigen receptors recognizing cancer-spevific tn glycopeptide variants
JP6764348B2 (ja) 2014-02-11 2020-09-30 ビステラ， インコーポレイテッド デングウイルスに対する抗体分子およびその使用
EP2915569A1 (en) 2014-03-03 2015-09-09 Cytune Pharma IL-15/IL-15Ralpha based conjugates purification method
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
EP2915543B1 (en) 2014-03-04 2018-05-09 Albert-Ludwigs-Universität Freiburg Polypeptides derived from Enterococcus and their use for vaccination and the generation of therapeutic antibodies
GB201403815D0 (en) 2014-03-04 2014-04-16 Mologic Ltd Assay
WO2015138920A1 (en) 2014-03-14 2015-09-17 Novartis Ag Antibody molecules to lag-3 and uses thereof
US9738702B2 (en) 2014-03-14 2017-08-22 Janssen Biotech, Inc. Antibodies with improved half-life in ferrets
EP3119425B1 (en) 2014-03-15 2020-09-23 Novartis AG Regulatable chimeric antigen receptor
WO2015142675A2 (en) 2014-03-15 2015-09-24 Novartis Ag Treatment of cancer using chimeric antigen receptor
WO2015140708A1 (en) 2014-03-19 2015-09-24 Pfizer Inc. Method of cell culture
WO2015143271A1 (en) 2014-03-21 2015-09-24 X-Body, Inc. Bi-specific antigen-binding polypeptides
CA2943405A1 (en) 2014-03-31 2015-10-08 Debiopharm International Sa Fgfr fusions
AU2015240599B2 (en) 2014-04-04 2020-11-19 Bionomics, Inc. Humanized antibodies that bind LGR5
DK3129470T3 (da) 2014-04-07 2021-07-05 Novartis Ag Behandling af cancer ved anvendelse af anti-CD19-kimær antigenreceptor
CA2940585C (en) 2014-04-15 2023-08-08 Helmholtz Zentrum Munchen - Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) Differential diagnosis of eczema and psoriasis
MY191217A (en) 2014-04-15 2022-06-09 Univ Griffith Group a streptococcus vaccine
US10544231B2 (en) 2014-04-16 2020-01-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies for the prevention or the treatment of bleeding episodes
GB201407132D0 (en) 2014-04-23 2014-06-04 Velgene Biotechnology Marker for neurodegenerative disorders
WO2015164743A2 (en) 2014-04-24 2015-10-29 Dana-Farber Cancer Institute, Inc. Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response
EP3148567A4 (en) 2014-04-25 2018-01-10 The Brigham and Women's Hospital, Inc. Methods to manipulate alpha-fetoprotein (afp)
EP3137910B1 (en) 2014-04-30 2019-09-25 Klinikum rechts der Isar der Technischen Universität München Diagnosis of multiple sclerosis
CA2944712A1 (en) 2014-05-01 2015-11-05 Genentech, Inc. Anti-factor d antibody variants and uses thereof
GB201407852D0 (en) 2014-05-02 2014-06-18 Iontas Ltd Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules
KR20200000495A (ko) 2014-05-14 2020-01-02 카르스젠 테라퓨틱스 리미티드 키메라 항원 수용체 단백질을 코딩하는 핵산 및 키메라 항원 수용체 단백질을 발현하는 t 림프구
TWI694836B (zh) 2014-05-16 2020-06-01 英商葛蘭素史克智慧財產管理有限公司 抗體調配物
US20170267780A1 (en) 2014-05-16 2017-09-21 Medimmune, Llc Molecules with altered neonate fc receptor binding having enhanced therapeutic and diagnostic properties
EA201692458A1 (ru) 2014-05-28 2017-06-30 Агенус Инк. Анти-gitr антитела и способы их применения
IL290655B2 (en) 2014-05-29 2024-05-01 Us Health Anti-human papillomavirus 16 E7 T-cell chelates
US10124070B2 (en) 2014-06-06 2018-11-13 Redwood Bioscience, Inc. Anti-HER2 antibody-maytansine conjugates and methods of use thereof
WO2015189816A1 (en) 2014-06-13 2015-12-17 Friedrich Miescher Institute For Biomedical Research New treatment against influenza virus
TWI831106B (zh) 2014-06-20 2024-02-01 日商中外製藥股份有限公司 用於因第viii凝血因子及/或活化的第viii凝血因子的活性降低或欠缺而發病及/或進展的疾病之預防及/或治療之醫藥組成物
EP3157535A1 (en) 2014-06-23 2017-04-26 Friedrich Miescher Institute for Biomedical Research Methods for triggering de novo formation of heterochromatin and or epigenetic silencing with small rnas
CN106659772B (zh) 2014-06-26 2021-08-31 耶鲁大学 在疾病和紊乱的治疗中调节肾酶的组合物和方法
TW201628647A (zh) 2014-06-27 2016-08-16 賽諾菲公司 抗－ｉｌ４－ｉｌ１３雙特異性抗體
US20170165261A1 (en) 2014-07-01 2017-06-15 Brian Arthur Hemmings Combination of a brafv600e inhibitor and mertk inhibitor to treat melanoma
WO2016007919A2 (en) 2014-07-11 2016-01-14 Regents Of The University Of Minnesota Antibody fragments for detecting cancer and methods of use
KR102569494B1 (ko) 2014-07-15 2023-08-21 이슘 리서치 디벨롭먼트 컴퍼니 오브 더 히브루 유니버시티 오브 예루살렘 엘티디. Cd44의 단리된 폴리펩타이드 및 이의 사용
EP3808756A1 (en) 2014-07-17 2021-04-21 The Trustees of The University of Pennsylvania Methods for using exosomes to monitor transplanted organ status
KR102465120B1 (ko) 2014-07-17 2022-11-10 노보 노르디스크 에이/에스 점도를 감소시키기 위한 trem-1 항체의 부위 지정 돌연변이유발
BR112017001242A2 (pt) 2014-07-21 2017-12-05 Novartis Ag tratamento de câncer usando um receptor antigênico quimérico a cd33
WO2016014553A1 (en) 2014-07-21 2016-01-28 Novartis Ag Sortase synthesized chimeric antigen receptors
JP7054622B2 (ja) 2014-07-21 2022-04-14 ノバルティス アーゲー ヒト化抗ｂｃｍａキメラ抗原受容体を使用した癌の処置
EP3193915A1 (en) 2014-07-21 2017-07-26 Novartis AG Combinations of low, immune enhancing. doses of mtor inhibitors and cars
WO2018140026A1 (en) 2017-01-27 2018-08-02 Memorial Sloan Kettering Cancer Center Bispecific her2 and cd3 binding molecules
DK3453406T3 (da) 2014-07-29 2021-07-12 Cellectis ROR1(NTRKR1)-specifikke kimære antigenreceptorer til cancerimmunterapi
WO2016016278A2 (en) 2014-07-29 2016-02-04 Neurimmune Holding Ag Human-derived anti-huntingtin (htt) antibodies and uses thereof
EP4205749A1 (en) 2014-07-31 2023-07-05 Novartis AG Subset-optimized chimeric antigen receptor-containing cells
AR101669A1 (es) 2014-07-31 2017-01-04 Amgen Res (Munich) Gmbh Constructos de anticuerpos para cdh19 y cd3
JP2017522893A (ja) 2014-07-31 2017-08-17 セレクティスＣｅｌｌｅｃｔｉｓ Ｒｏｒ１特異的多重鎖キメラ抗原受容体
CA2952540C (en) 2014-07-31 2022-06-21 Amgen Research (Munich) Gmbh Bispecific single chain antibody construct with enhanced tissue distribution
JP6749312B2 (ja) 2014-07-31 2020-09-02 アムゲン リサーチ （ミュンヘン） ゲーエムベーハーＡＭＧＥＮ Ｒｅｓｅａｒｃｈ（Ｍｕｎｉｃｈ）ＧｍｂＨ 最適化された種間特異的二重特異性単鎖抗体コンストラクト
JP6919118B2 (ja) 2014-08-14 2021-08-18 ノバルティス アーゲー ＧＦＲα−４キメラ抗原受容体を用いる癌の治療
SG11201700770PA (en) 2014-08-19 2017-03-30 Novartis Ag Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment
WO2016027859A1 (ja) 2014-08-20 2016-02-25 中外製薬株式会社 蛋白質溶液の粘度測定方法
CN113842468A (zh) 2014-09-02 2021-12-28 伊缪诺金公司 用于配制抗体药物缀合物组合物的方法
US10759868B2 (en) 2014-09-04 2020-09-01 Cellectis Trophoblast glycoprotein (5T4, TPBG) specific chimeric antigen receptors for cancer immunotherapy
ES2808914T3 (es) 2014-09-04 2021-03-02 Stemcell Tech Inc Complejos de anticuerpo solubles para la activación y expansión de linfocitos T o células NK
US20170281624A1 (en) 2014-09-13 2017-10-05 Novartis Ag Combination therapies of alk inhibitors
CA2961609C (en) 2014-09-17 2023-03-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-cd276 antibodies (b7h3)
PL3194443T3 (pl) 2014-09-17 2022-01-31 Novartis Ag Nakierowywanie komórek cytotoksycznych za pośrednictwem receptorów chimerycznych do immunoterapii adoptywnej
WO2016044588A1 (en) 2014-09-19 2016-03-24 The Regents Of The University Of Michigan Staphylococcus aureus materials and methods
WO2016046768A1 (en) 2014-09-24 2016-03-31 Friedrich Miescher Institute For Biomedical Research Lats and breast cancer
MA40764A (fr) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd Agent thérapeutique induisant une cytotoxicité
SG11201701925XA (en) 2014-09-30 2017-04-27 Neurimmune Holding Ag Human-derived anti-dipeptide repeats (dprs) antibody
EA201790737A1 (ru) 2014-10-03 2017-08-31 Новартис Аг Комбинированная терапия
WO2016057367A1 (en) 2014-10-06 2016-04-14 Dana-Farber Cancer Institute, Inc. Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response
EP3204119B1 (en) 2014-10-09 2021-06-09 Dana-Farber Cancer Institute, Inc. Multiple-variable il-2 dose regimen for treating immune disorders
EP4245376A3 (en) 2014-10-14 2023-12-13 Novartis AG Antibody molecules to pd-l1 and uses thereof
WO2016059602A2 (en) 2014-10-16 2016-04-21 Glaxo Group Limited Methods of treating cancer and related compositions
WO2016065329A1 (en) 2014-10-24 2016-04-28 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for inducing phagocytosis of mhc class i positive cells and countering anti-cd47/sirpa resistance
GB201419108D0 (en) 2014-10-27 2014-12-10 Glythera Ltd Materials and methods relating to linkers for use in antibody drug conjugates
US11471487B2 (en) 2014-10-31 2022-10-18 The Trustees Of The University Of Pennsylvania Compositions and methods of stimulating and expanding T cells
EP3215168B1 (en) 2014-10-31 2023-08-02 The Trustees of the University of Pennsylvania Altering gene expression in modified t cells and uses thereof
CA2966005C (en) 2014-10-31 2021-04-27 Abbvie Biotherapeutics Inc. Anti-cs1 antibodies and antibody drug conjugates
US20190030071A1 (en) 2014-11-03 2019-01-31 IMMURES S.r.I. T cell receptors
US9879087B2 (en) 2014-11-12 2018-01-30 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
US11072644B2 (en) 2014-11-12 2021-07-27 Allogene Therapeutics, Inc. Inhibitory chimeric antigen receptors
EP3218005B1 (en) 2014-11-12 2023-01-04 Seagen Inc. Glycan-interacting compounds and methods of use
MA40934A (fr) 2014-11-19 2017-09-27 Immunogen Inc Procédé de préparation de conjugués agent de liaison cellulaire-agent cytotoxique
KR101618458B1 (ko) 2014-11-28 2016-05-10 강원대학교산학협력단 항체에서 항원-항체 결합력과 양의 상관관계를 갖는 아미노산 서열에 대한 정보를 얻는 방법
US20180334490A1 (en) 2014-12-03 2018-11-22 Qilong H. Wu Methods for b cell preconditioning in car therapy
AU2015360609A1 (en) 2014-12-09 2017-06-29 Abbvie Inc. Antibody drug conjugates with cell permeable Bcl-xL inhibitors
CN107223123A (zh) 2014-12-09 2017-09-29 艾伯维公司 具有低细胞渗透性的bcl‑xl抑制性化合物以及包括它的抗体药物缀合物
US11001625B2 (en) 2014-12-10 2021-05-11 Tufts University VHH based binding antibodies for anthrax and botulinum toxins and methods of making and using therefor
SG11201704752WA (en) 2014-12-11 2017-07-28 Pierre Fabre Médicament Anti-c10orf54 antibodies and uses thereof
WO2016094881A2 (en) 2014-12-11 2016-06-16 Abbvie Inc. Lrp-8 binding proteins
EP3229909B1 (en) 2014-12-11 2020-10-14 Inbiomotion S.L. Binding members for human c-maf
US10703813B2 (en) 2014-12-19 2020-07-07 Universite De Nantes Anti IL-34 antibodies
WO2016097259A1 (en) 2014-12-19 2016-06-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting graft alterations
ES2862701T3 (es) 2014-12-22 2021-10-07 Univ Rockefeller Anticuerpos agonistas anti-MERTK y usos de los mismos
JP2018504400A (ja) 2015-01-08 2018-02-15 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． Ｌｉｎｇｏ‐１拮抗薬及び脱髄障害の治療のための使用
WO2016115345A1 (en) 2015-01-14 2016-07-21 The Brigham And Women's Hospital, Treatment of cancer with anti-lap monoclonal antibodies
TWI726862B (zh) 2015-01-23 2021-05-11 法商賽諾菲公司 特異性結合ｃｄ３及/或ｃｄ１２３之抗-ｃｄ３抗體，抗-ｃｄ１２３抗體及雙特異性抗體
KR102329836B1 (ko) 2015-01-26 2021-11-19 셀렉티스 암 면역치료를 위한 항-CLL1 특이적 단일-체인 키메라 항원 수용체들(scCARS)
CN107835820B (zh) 2015-01-26 2021-10-15 芝加哥大学 识别癌症特异性IL13Rα2的CAR T细胞
CN107683289B (zh) 2015-01-26 2021-08-06 芝加哥大学 IL13Rα2结合剂和其在癌症治疗中的用途
MA41414A (fr) 2015-01-28 2017-12-05 Centre Nat Rech Scient Protéines de liaison agonistes d' icos
AU2015380397B2 (en) 2015-01-31 2021-10-21 The Trustees Of The University Of Pennsylvania Compositions and methods for T cell delivery of therapeutic molecules
US11161907B2 (en) 2015-02-02 2021-11-02 Novartis Ag Car-expressing cells against multiple tumor antigens and uses thereof
US9969800B2 (en) 2015-02-05 2018-05-15 Chugai Seiyaku Kabushiki Kaisha IL-8 antibodies
WO2016130539A2 (en) 2015-02-09 2016-08-18 Memorial Sloan Kettering Cancer Center Multi-specific antibodies with affinity for human a33 antigen and dota metal complex and uses thereof
US10266584B2 (en) 2015-02-09 2019-04-23 Inserm (Institut National De La Sante Et De La Recherche Medicale) Antibodies specific to glycoprotein (GP) of Ebolavirus and uses for the treatment and diagnosis of ebola virus infection
CA2972393A1 (en) 2015-02-27 2016-09-01 Chugai Seiyaku Kabushiki Kaisha Composition for treating il-6-related diseases
PT3265123T (pt) 2015-03-03 2023-02-01 Kymab Ltd Anticorpos, usos e métodos
EP3265825A4 (en) 2015-03-06 2018-08-08 Dana-Farber Cancer Institute, Inc. Pd-l2 biomarkers predictive of pd-1 pathway inhibitor responses in esophagogastric cancers
CA2978374A1 (en) 2015-03-06 2016-09-15 Csl Behring Recombinant Facility Ag Modified von willebrand factor having improved half-life
WO2016142385A1 (en) 2015-03-11 2016-09-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for diagnosing ocular anterior chamber dysgenesis
WO2016149368A1 (en) 2015-03-17 2016-09-22 Memorial Sloan Kettering Cancer Center Anti-muc16 antibodies and uses thereof
AU2016232749B2 (en) 2015-03-18 2021-09-23 The Johns Hopkins University Novel monoclonal antibody inhibitors targeting potassium channel KCNK9
LT3280440T (lt) 2015-04-06 2023-02-27 Bioverativ Usa Inc. Humanizuoti antikūnai prieš c1s ir jų panaudojimo būdai
WO2016162368A1 (en) 2015-04-07 2016-10-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Non-invasive imaging of tumor pd-l1 expression
HUE059218T2 (hu) 2015-04-08 2022-11-28 Novartis Ag CD20-terápiák, CD22-terápiák és kombinációs terápiák CD19 kiméra antigénreceptort (CAR-t) expresszáló sejttel
KR20180023892A (ko) 2015-04-17 2018-03-07 암젠 리서치 (뮌헨) 게엠베하 Cdh3 및 cd3에 대한 이중 특이성 항체 작제물
KR102057767B1 (ko) 2015-04-17 2019-12-19 에프. 호프만-라 로슈 아게 응고 인자 및 다중특이적 항체의 조합 요법
WO2016172583A1 (en) 2015-04-23 2016-10-27 Novartis Ag Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
BR112017023158A2 (pt) 2015-04-30 2018-07-24 Harvard College anticorpos anti-ap2 e agentes de ligação de antígeno para tratar distúrbios metabólicos
JP7019423B2 (ja) 2015-05-06 2022-02-15 ヤンセン バイオテツク，インコーポレーテツド 前立腺特異的膜抗原（ｐｓｍａ）二重特異性結合剤及びその使用
CA2984794A1 (en) 2015-05-07 2016-11-10 Agenus Inc. Anti-ox40 antibodies and methods of use thereof
EP3447075B1 (en) 2015-05-15 2023-08-09 The General Hospital Corporation Antagonistic anti-tumor necrosis factor receptor superfamily antibodies
CN114634943A (zh) 2015-05-18 2022-06-17 T细胞受体治疗公司 使用融合蛋白对tcr重编程的组合物和方法
TW201706300A (zh) 2015-05-20 2017-02-16 瑟勒提斯公司 用於癌症免疫療法之抗－ｇｄ３專一性嵌合抗原受體
AU2016263808B2 (en) 2015-05-21 2019-01-03 Harpoon Therapeutics, Inc. Trispecific binding proteins and methods of use
BR112017025564B8 (pt) 2015-05-29 2022-01-04 Agenus Inc Anticorpos anti-ctla-4 e métodos de uso dos mesmos
SI3303395T1 (sl) 2015-05-29 2020-03-31 Abbvie Inc. Protitelesa proti CD40 in njihove uporabe
TW201710286A (zh) 2015-06-15 2017-03-16 艾伯維有限公司 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白
DK3310800T3 (da) 2015-06-19 2022-02-28 Centurion Biopharma Corp Leveringssystem til styret lægemiddelfrigivelse
SG10202010735PA (en) 2015-07-06 2020-11-27 UCB Biopharma SRL Tau-binding antibodies
EA036821B1 (ru) 2015-07-06 2020-12-23 Юсб Биофарма Срл Тау-связывающие антитела
WO2017005847A1 (en) 2015-07-07 2017-01-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies having specificity to myosin 18a and uses thereof
WO2017019897A1 (en) 2015-07-29 2017-02-02 Novartis Ag Combination therapies comprising antibody molecules to tim-3
EP3328418A1 (en) 2015-07-29 2018-06-06 Novartis AG Combination therapies comprising antibody molecules to pd-1
PT3317301T (pt) 2015-07-29 2021-07-09 Novartis Ag Terapias de associação compreendendo moléculas de anticorpo contra lag-3
TWI793062B (zh) 2015-07-31 2023-02-21 德商安美基研究（慕尼黑）公司 Ｄｌｌ３及ｃｄ３抗體構築體
TWI717375B (zh) 2015-07-31 2021-02-01 德商安美基研究（慕尼黑）公司 Ｃｄ７０及ｃｄ３抗體構築體
TWI829617B (zh) 2015-07-31 2024-01-21 德商安美基研究（慕尼黑）公司 Ｆｌｔ３及ｃｄ３抗體構築體
TWI744242B (zh) 2015-07-31 2021-11-01 德商安美基研究（慕尼黑）公司 Egfrviii及cd3抗體構築體
TWI796283B (zh) 2015-07-31 2023-03-21 德商安美基研究（慕尼黑）公司 Ｍｓｌｎ及ｃｄ３抗體構築體
EP3331536A4 (en) 2015-08-03 2019-03-27 The Regents of The University of California COMPOSITIONS AND METHODS FOR MODULATING ABHD2 ACTIVITY
EP3331916A1 (en) 2015-08-04 2018-06-13 GlaxoSmithKline Intellectual Property Development Limited Combination treatments and uses and methods thereof
EP3331917A1 (en) 2015-08-04 2018-06-13 GlaxoSmithKline Intellectual Property Development Limited Combination treatments and uses and methods thereof
EP3331918A1 (en) 2015-08-04 2018-06-13 GlaxoSmithKline Intellectual Property Development Limited Combination treatments and uses and methods thereof
WO2017021912A1 (en) 2015-08-06 2017-02-09 Glaxosmithkline Intellectual Property Development Limited Combined tlrs modulators with anti ox40 antibodies
TW201716084A (zh) 2015-08-06 2017-05-16 葛蘭素史克智慧財產發展有限公司 組合物及其用途與治療
US10765690B2 (en) 2015-08-06 2020-09-08 Glaxosmithkline Intellectual Property Development Limited TLR4 agonists and compositions thereof and their use in the treatment of cancer
WO2017025871A1 (en) 2015-08-07 2017-02-16 Glaxosmithkline Intellectual Property Development Limited Combination therapy comprising anti ctla-4 antibodies
WO2017027392A1 (en) 2015-08-07 2017-02-16 Novartis Ag Treatment of cancer using chimeric cd3 receptor proteins
WO2017025458A1 (en) 2015-08-07 2017-02-16 Gamamabs Pharma Antibodies, antibody drug conjugates and methods of use
BR112018002600A2 (pt) 2015-08-11 2018-10-23 Cellectis células para imunoterapia modificadas para direcionamento ao antígeno cd38 e para inativação do gene cd38
CN108135932A (zh) 2015-08-28 2018-06-08 宾夕法尼亚大学董事会 表达嵌合细胞内信号传导分子的细胞的方法和组合物
CN108348551A (zh) 2015-08-28 2018-07-31 宾夕法尼亚大学董事会 表达嵌合细胞内信号传导分子的细胞的方法和组合物
US10323091B2 (en) 2015-09-01 2019-06-18 Agenus Inc. Anti-PD-1 antibodies and methods of use thereof
WO2017037203A1 (en) 2015-09-02 2017-03-09 Immutep S.A.S. Anti-LAG-3 Antibodies
TWI814162B (zh) 2015-09-18 2023-09-01 日商中外製藥股份有限公司 Il-8結合抗體及其用途
JP7001585B2 (ja) 2015-09-23 2022-02-04 ファイザー・インク 細胞および細胞培養の方法
WO2017059551A1 (en) 2015-10-08 2017-04-13 Zymeworks Inc. Antigen-binding polypeptide constructs comprising kappa and lambda light chains and uses thereof
WO2017060397A1 (en) 2015-10-09 2017-04-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of subjects suffering from melanoma metastases
US10149887B2 (en) 2015-10-23 2018-12-11 Canbas Co., Ltd. Peptides and peptidomimetics in combination with t cell activating and/or checkpoint inhibiting agents for cancer treatment
JP6921067B2 (ja) 2015-10-28 2021-08-18 イエール ユニバーシティ ヒト化抗Ｄｋｋ２抗体およびその使用方法
WO2017072669A1 (en) 2015-10-28 2017-05-04 Friedrich Miescher Institute For Biomedical Research Tenascin-w and biliary tract cancers
KR20180077193A (ko) 2015-10-30 2018-07-06 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 예후 방법
CN108472382A (zh) 2015-10-30 2018-08-31 豪夫迈·罗氏有限公司 抗-因子d抗体变体缀合物及其用途
WO2017075173A2 (en) 2015-10-30 2017-05-04 Genentech, Inc. Anti-factor d antibodies and conjugates
ITUB20155272A1 (it) 2015-11-02 2017-05-02 Scuola Normale Superiore Intracellular antibody
TW201720459A (zh) 2015-11-02 2017-06-16 妮翠斯製藥公司 Ntn1中和劑與抑制後生控制之藥物之組合治療
CA3004048A1 (en) 2015-11-03 2017-05-11 Regents Of The University Of Minnesota Cd200 inhibitors and methods of use thereof
US11235063B2 (en) 2015-11-03 2022-02-01 Merck Patent Gmbh Bi-specific antibodies for enhanced tumor selectivity and inhibition and uses thereof
ITUB20155097A1 (it) 2015-11-05 2017-05-05 Biouniversa Srl Anticorpi umanizzati anti-BAG3
US20190209697A1 (en) 2015-11-05 2019-07-11 The Regents Of The University Of California Cells labelled with lipid conjugates and methods of use thereof
JP7448174B2 (ja) 2015-11-09 2024-03-12 ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア アミロイドベータ中間領域エピトープおよびそれに対する立体配座選択的抗体
CA3004790A1 (en) 2015-11-10 2017-05-18 Visterra, Inc. Lipopolysaccharide binding antibody-antimicrobial peptide conjugates and uses thereof
EP3373969A4 (en) 2015-11-12 2019-08-14 Siamab Therapeutics, Inc. GLYCANINTERAGING COMPOUNDS AND METHOD OF USE
US11660340B2 (en) 2015-11-18 2023-05-30 Chugai Seiyaku Kabushiki Kaisha Combination therapy using T cell redirection antigen binding molecule against cell having immunosuppressing function
US11649293B2 (en) 2015-11-18 2023-05-16 Chugai Seiyaku Kabushiki Kaisha Method for enhancing humoral immune response
GB201520567D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520565D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520566D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520564D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520589D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520562D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520542D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520603D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520545D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520541D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
WO2017089786A1 (en) 2015-11-23 2017-06-01 Immunocore Limited Peptides
GB201520570D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520550D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520563D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201604468D0 (en) 2016-03-16 2016-04-27 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520544D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520597D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520595D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520546D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520558D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520539D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201607534D0 (en) 2016-04-29 2016-06-15 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520579D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520543D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520548D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520559D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201607535D0 (en) 2016-04-29 2016-06-15 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520592D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520568D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd Peptides
GB201520583D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520575D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520557D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520536D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
SI3380522T1 (sl) 2015-11-25 2024-02-29 Visterra, Inc. Molekule protitelesa proti APRIL in uporabe le-teh
JP2019501139A (ja) 2015-11-25 2019-01-17 イミュノジェン・インコーポレーテッド 医薬製剤及びその使用
JP2019500327A (ja) 2015-11-30 2019-01-10 アッヴィ・インコーポレイテッド 抗ｈｕＬＲＲＣ１５抗体薬物コンジュゲート及びその使用方法
CA3006610A1 (en) 2015-11-30 2017-06-08 Abbvie Inc. Anti-hulrrc15 antibody drug conjugates and methods for their use
KR20180083936A (ko) 2015-12-01 2018-07-23 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 조합 치료 및 그의 용도 및 방법
JP7227007B2 (ja) 2015-12-02 2023-02-21 ストサイエンシス， インコーポレイテッド グリコシル化ｂｔｌａ（ｂ－及びｔ－リンパ球減弱因子）に特異的な抗体
MX2018006613A (es) 2015-12-02 2019-01-30 Stcube & Co Inc Anticuerpos y moleculas que se unen inmunoespecificamente a btn1a1 y los usos terapeuticos de los mismos.
US11052111B2 (en) 2015-12-08 2021-07-06 Chimera Bioengineering, Inc. Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses
US10829562B2 (en) 2015-12-10 2020-11-10 Katholieke Universiteit Leuven Haemorrhagic disorder due to ventricular assist device
EP4374926A3 (en) 2015-12-15 2024-08-07 OncoC4, Inc. Chimeric and humanized anti-human ctla4 monoclonal antibodies and uses thereof
CN108601819B (zh) 2015-12-17 2022-03-15 约翰霍普金斯大学 用死亡受体激动剂改善系统性硬化症
WO2017106656A1 (en) 2015-12-17 2017-06-22 Novartis Ag Antibody molecules to pd-1 and uses thereof
WO2017106810A2 (en) 2015-12-17 2017-06-22 Novartis Ag Combination of c-met inhibitor with antibody molecule to pd-1 and uses thereof
GB201522394D0 (en) 2015-12-18 2016-02-03 Ucb Biopharma Sprl Antibodies
EP3184544A1 (en) 2015-12-23 2017-06-28 Julius-Maximilians-Universität Würzburg Glycoprotein v inhibitors for use as coagulants
WO2017110980A1 (ja) 2015-12-25 2017-06-29 中外製薬株式会社 増強された活性を有する抗体及びその改変方法
AU2017204683B2 (en) 2015-12-31 2023-03-16 Syncerus S.À R.L. Compositions and methods for assessing the risk of cancer occurrence
US20210198368A1 (en) 2016-01-21 2021-07-01 Novartis Ag Multispecific molecules targeting cll-1
GB201601690D0 (en) 2016-01-29 2016-03-16 Heptares Therapeutics Ltd G proteins
CR20180420A (es) 2016-02-03 2018-12-05 Amgen Inc Constructos de anticuerpo biespecíficos para bcma y cd3 que se ligan a células t
US10781264B2 (en) 2016-02-03 2020-09-22 Amgen Research (Munich) Gmbh PSMA and CD3 bispecific T cell engaging antibody constructs
EA039859B1 (ru) 2016-02-03 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Биспецифические конструкты антител, связывающие egfrviii и cd3
KR20180105233A (ko) 2016-02-05 2018-09-27 이뮤노젠 아이엔씨 세포 결합제-세포독성제 접합체를 제조하기 위한 효율적인 방법
EP3202788A1 (en) 2016-02-05 2017-08-09 MediaPharma S.r.l. Endosialin-binding antibody
EP3205663A1 (en) 2016-02-15 2017-08-16 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Means and methods for inhibiting gene expression
EP3207937A1 (en) 2016-02-17 2017-08-23 Royal College of Surgeons in Ireland A method of treating or preventing sepsis
WO2017147258A1 (en) 2016-02-23 2017-08-31 Indiana University Research & Technology Corporation Emapii neutralizing antibody limits influenza a virus (iav)-induced lung injury
BR112018067525A2 (pt) 2016-02-26 2019-02-05 Centre Nat Rech Scient anticorpos tendo especificidade para o btla e seus usos
EP4299586A3 (en) 2016-03-02 2024-04-03 Idexx Laboratories, Inc. Methods and compositions for the detection and diagnosis of renal disease and periodontal disease
JP2019513347A (ja) 2016-03-04 2019-05-30 ノバルティス アーゲー 複数のキメラ抗原受容体（ｃａｒ）分子を発現する細胞およびその使用
US11921116B2 (en) 2016-03-09 2024-03-05 Memorial Sloan Kettering Cancer Center Enigma and CDH18 as companion diagnostics for CDK4 inhibitors
KR20180116215A (ko) 2016-03-14 2018-10-24 추가이 세이야쿠 가부시키가이샤 암의 치료에 이용하기 위한 세포상해 유도 치료제
KR20180119670A (ko) 2016-03-15 2018-11-02 아스트라제네카 아베 아밀로이드 베타의 축적과 관련된 질환의 치료를 위한 bace 억제제와 항체 또는 항원 결합 단편의 조합
EP3219727B1 (en) 2016-03-17 2020-12-16 Tillotts Pharma AG Anti-tnf alpha-antibodies and functional fragments thereof
CA3011502A1 (en) 2016-03-17 2017-09-21 Numab Innovation Ag Anti-tnf.alpha.-antibodies and functional fragments thereof
BR112018017276A2 (pt) 2016-03-17 2019-02-05 Numab Innovation Ag anticorpos anti-tnf-alfa e fragmentos funcionais dos mesmos
PL3219726T3 (pl) 2016-03-17 2021-07-19 Tillotts Pharma Ag Przeciwciała anty-tnf alfa i ich funkcjonalne fragmenty
WO2017158101A1 (en) 2016-03-17 2017-09-21 Numab Innovation Ag ANTI-TNFα-ANTIBODIES AND FUNCTIONAL FRAGMENTS THEREOF
AU2017238172B2 (en) 2016-03-21 2024-06-27 Marengo Therapeutics, Inc. Multispecific and multifunctional molecules and uses thereof
CN108697799A (zh) 2016-03-22 2018-10-23 生态学有限公司 抗lgr5单克隆抗体的施用
EP3432924A1 (en) 2016-03-23 2019-01-30 Novartis AG Cell secreted minibodies and uses thereof
JP7080213B2 (ja) 2016-03-23 2022-06-03 スーチョウ トランセンタ セラピューティクス カンパニー，リミテッド 新規抗ｐｄ－ｌ１抗体
TW202302144A (zh) 2016-03-25 2023-01-16 美商威特拉公司 登革病毒的抗體分子之配方設計
BR112018069318A2 (pt) 2016-03-28 2019-01-22 Toray Industries composição farmacêutica para tratamento e/ou prevenção de um câncer, anticorpo ou fragmento do mesmo, combinação farmacêutica para tratamento e/ou prevenção de um câncer e método para tratar e/ou prevenir um câncer
AU2017244108B2 (en) 2016-03-29 2021-03-18 University Of Southern California Chimeric antigen receptors targeting cancer
ITUA20162242A1 (it) 2016-04-01 2017-10-01 St Biochimico Italiano Giovanni Lorenzini Spa Un nuovo anticorpo anti-erbb2
IL262010B (en) 2016-04-04 2022-09-01 Bioverativ Usa Inc Anti-complement factor bb antibodies and their uses
JP7253923B2 (ja) 2016-04-05 2023-04-07 ファイザー・インク 細胞培養プロセス
JP7281795B2 (ja) 2016-04-07 2023-05-26 ザ・ジョンズ・ホプキンス・ユニバーシティー 膵炎および疼痛をデス受容体アゴニストで処置するための組成物および方法
DK3443096T5 (da) 2016-04-15 2024-09-09 Novartis Ag Sammensætninger og fremgangsmåder til selektiv ekspression af kimære antigenreceptorer
WO2017181098A2 (en) 2016-04-15 2017-10-19 Visterra, Inc. Antibody molecules to zika virus and uses thereof
JOP20170091B1 (ar) 2016-04-19 2021-08-17 Amgen Res Munich Gmbh إعطاء تركيبة ثنائية النوعية ترتبط بـ cd33 وcd3 للاستخدام في طريقة لعلاج اللوكيميا النخاعية
EA037960B1 (ru) 2016-04-27 2021-06-15 Эббви Инк. Способ лечения эозинофильного эзофагита с применением антитела против il-13
WO2017194568A1 (en) 2016-05-11 2017-11-16 Sanofi Treatment regimen using anti-muc1 maytansinoid immunoconjugate antibody for the treatment of tumors
TWI821905B (zh) 2016-05-11 2023-11-11 美商安美基公司 使用麩醯胺合成酶基因內互補載體直接選擇表現高水準異質蛋白的細胞
WO2017200981A1 (en) 2016-05-16 2017-11-23 Baxalta Incorporated Anti-factor ix padua antibodies
RS61659B1 (sr) 2016-05-17 2021-04-29 Abbvie Biotherapeutics Inc Konjugati antitelo lek anti-cmet i metode za njihovu upotrebu
AU2017268460B2 (en) 2016-05-20 2023-12-14 Harpoon Therapeutics, Inc. Single domain serum albumin binding protein
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
EP3458093A1 (de) 2016-05-20 2019-03-27 Christoph Karl Pharmazeutische zusammensetzungen mit anti-rankl-antikörpern, kalzium und vitamin d, geeignet zur behandlung und/oder prophylaxe von erkrankungen des knochenstoffwechsels und von therapiebedingten nebenwirkungen wie hypokalzämien
CN109415441B (zh) 2016-05-24 2023-04-07 英斯梅德股份有限公司 抗体及其制备方法
WO2017203051A1 (en) 2016-05-26 2017-11-30 University College Cork - National University Of Ireland, Cork An engineered gram positive bacterium
CN109476750B (zh) 2016-05-27 2022-02-01 艾伯维生物制药股份有限公司 抗cd40抗体及其用途
TWI781934B (zh) 2016-05-27 2022-11-01 美商艾吉納斯公司 抗-tim-3抗體及其使用方法
WO2017205747A1 (en) 2016-05-27 2017-11-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Flt3-specific chimeric antigen receptors and methods using same
WO2017205745A1 (en) 2016-05-27 2017-11-30 Abbvie Biotherapeutics Inc. Anti-4-1bb antibodies and their uses
WO2017210617A2 (en) 2016-06-02 2017-12-07 Porter, David, L. Therapeutic regimens for chimeric antigen receptor (car)- expressing cells
JP2019517499A (ja) 2016-06-02 2019-06-24 イムノコア リミテッド ｇｐ１００特異的ＴＣＲ−抗ＣＤ３ ｓｃＦｖ融合タンパク質の投薬レジメン
US11534496B2 (en) 2016-06-07 2022-12-27 The Brigham And Women's Hospital, Inc. Compositions and methods relating to T peripheral helper cells in autoantibody-associated conditions
BR112018075649A2 (pt) 2016-06-08 2019-04-09 Abbvie Inc. anticorpos anti-b7-h3 e conjugados de fármaco de anticorpo
JP6751165B2 (ja) 2016-06-08 2020-09-02 アッヴィ・インコーポレイテッド 抗ｂ７−ｈ３抗体及び抗体薬物コンジュゲート
CA3027044A1 (en) 2016-06-08 2017-12-14 Abbvie Inc. Anti-b7-h3 antibodies and antibody drug conjugates
GB201610198D0 (en) 2016-06-10 2016-07-27 Ucb Biopharma Sprl Anti-ige antibodies
UA126905C2 (uk) 2016-06-13 2023-02-22 Ай-Маб Байофарма Юес Лімітед Антитіло до pd-l1 та його застосування
WO2017220555A1 (en) 2016-06-20 2017-12-28 F-Star Beta Limited Lag -3 binding members
CA3027612A1 (en) 2016-06-20 2017-12-28 F-Star Delta Limited Binding molecules binding pd-l1 and lag-3
MA45602A (fr) 2016-07-08 2019-05-15 Staten Biotechnology B V Anticorps anti-apoc3 et leurs méthodes d'utilisation
WO2018013714A1 (en) 2016-07-13 2018-01-18 Biogen Ma Inc. Dosage regimens of lingo-1 antagonists and uses for treatment of demyelinating disorders
JP2018035137A (ja) 2016-07-13 2018-03-08 マブイミューン ダイアグノスティックス エイジーＭａｂｉｍｍｕｎｅ Ｄｉａｇｎｏｓｔｉｃｓ Ａｇ 新規な抗線維芽細胞活性化タンパク質（ｆａｐ）結合薬剤およびその使用
WO2018013918A2 (en) 2016-07-15 2018-01-18 Novartis Ag Treatment and prevention of cytokine release syndrome using a chimeric antigen receptor in combination with a kinase inhibitor
US11365252B2 (en) 2016-07-20 2022-06-21 University Of Utah Research Foundation CD229 CAR T cells and methods of use thereof
BR112019001570A2 (pt) 2016-07-28 2019-07-09 Novartis Ag terapias de combinação de receptores de antígeno quiméricos e inibidores de pd-1
CN109661406A (zh) 2016-07-29 2019-04-19 国家医疗保健研究所 靶向肿瘤相关巨噬细胞的抗体及其用途
GB201613167D0 (en) 2016-07-29 2016-09-14 Univ Southampton Cancer and b-cell related disease therapy
CN110267677A (zh) 2016-08-01 2019-09-20 诺华股份有限公司 使用与原m2巨噬细胞分子抑制剂组合的嵌合抗原受体治疗癌症
WO2018052556A1 (en) 2016-08-02 2018-03-22 Visterra, Inc. Engineered polypeptides and uses thereof
EP3494138A1 (en) 2016-08-02 2019-06-12 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
EP3494140A1 (en) 2016-08-04 2019-06-12 GlaxoSmithKline Intellectual Property Development Ltd Anti-icos and anti-pd-1 antibody combination therapy
US11447542B2 (en) 2016-08-05 2022-09-20 Medimmune, Llc Anti-O2 antibodies and uses thereof
GB201614627D0 (en) 2016-08-30 2016-10-12 Glaxosmithkline Ip Dev Ltd Antigen binding proteins
MX2019002510A (es) 2016-09-06 2019-06-24 Chugai Pharmaceutical Co Ltd Metodos para usar un anticuerpo biespecifico que reconoce el factor de coagulacion ix y/o el factor de coagulacion ix activado y el factor de coagulacion x y/o factor de coagulacion x activado.
AU2017323583A1 (en) 2016-09-07 2019-03-14 Glaxosmithkline Intellectual Property Development Limited Methods for purifying antibodies
EP3293271A1 (en) 2016-09-12 2018-03-14 The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin Marker and target as a diagnostic variable and target for therapy of metastatic cancer
EP3512547B1 (en) 2016-09-14 2020-11-11 AbbVie Biotherapeutics Inc. Anti-pd-1 antibodies
SG11201901789WA (en) 2016-09-19 2019-03-28 I Mab Anti-gm-csf antibodies and uses thereof
US11136409B2 (en) 2016-09-20 2021-10-05 Dana-Farber Cancer Institute, Inc. Compositions and methods for identification, assessment, prevention, and treatment of AML using USP10 biomarkers and modulators
EP4360714A3 (en) 2016-09-21 2024-07-24 Nextcure, Inc. Antibodies for siglec-15 and methods of use thereof
AU2017330346A1 (en) 2016-09-21 2019-02-21 Nextcure, Inc. Antibodies for Siglec-15 and methods of use thereof
WO2018057955A1 (en) 2016-09-23 2018-03-29 Elstar Therapeutics, Inc. Multispecific antibody molecules comprising lambda and kappa light chains
WO2018067993A1 (en) 2016-10-07 2018-04-12 TCR2 Therapeutics Inc. Compositions and methods for t-cell receptors reprogramming using fusion proteins
TW202340473A (zh) 2016-10-07 2023-10-16 瑞士商諾華公司 利用嵌合抗原受體之癌症治療
TWI843168B (zh) 2016-10-11 2024-05-21 美商艾吉納斯公司 抗ｌａｇ－３抗體及其使用方法
PE20191031A1 (es) 2016-10-12 2019-08-05 Bioverativ Usa Inc ANTICUERPOS ANTI-C1s Y METODOS DE USO DE LOS MISMOS
AU2017346488A1 (en) 2016-10-19 2019-05-30 Humabs Biomed Sa Anti-O1 antibodies and uses thereof
BR112019008335A2 (pt) 2016-10-28 2020-01-28 Toray Industries conjugado de um anticorpo, composição farmacêutica e método para o tratamento e/ou a prevenção de um câncer
US11249082B2 (en) 2016-10-29 2022-02-15 University Of Miami Zika virus assay systems
MA46779A (fr) 2016-11-02 2019-09-11 Health Research Inc Traitement combiné avec des conjugués anticorps-médicament et des inhibiteurs de parp
EP3534947A1 (en) 2016-11-03 2019-09-11 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses & methods
EP3535288A1 (en) 2016-11-07 2019-09-11 Immunocore Limited Peptides
CA3042989A1 (en) 2016-11-07 2018-05-11 Junho Chung Anti-family with sequence similarity 19, member a5 antibodies and method of use thereof
IT201600111877A1 (it) 2016-11-07 2018-05-07 Biouniversa Srl Anti-BAG3 antibodies in combination with inhibitors of immune check-point for therapeutic use
ES2893249T3 (es) 2016-11-09 2022-02-08 Philogen Spa Inmunoconjugados que comprenden IL-2, anticuerpo anti-fibronectina y TNF-alfa mutante
EP3541847A4 (en) 2016-11-17 2020-07-08 Seattle Genetics, Inc. COMPOUNDS INTERACTING WITH GLYCANE AND METHODS OF USE
WO2018091720A1 (en) 2016-11-21 2018-05-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the prophylactic treatment of metastases
JP7291396B2 (ja) 2016-11-22 2023-06-15 ティーシーアール２ セラピューティクス インク． 融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法
EP3544628A4 (en) 2016-11-23 2020-11-18 Immunoah Therapeutics, Inc. 4-1BB BINDING PROTEINS AND THEIR USES
JP7215997B2 (ja) 2016-11-23 2023-01-31 ハープーン セラピューティクス，インク． 前立腺特異的膜抗原（ｐｓｍａ）を標的とする三重特異性タンパク質と使用方法
CA3044659A1 (en) 2016-11-23 2018-05-31 Harpoon Therapeutics, Inc. Prostate specific membrane antigen binding protein
BR112019008265A2 (pt) 2016-11-28 2019-07-09 Chugai Pharmaceutical Co Ltd molécula de ligação ao ligante cuja atividade de li-gação ao ligante é ajustável
KR20190090822A (ko) 2016-12-01 2019-08-02 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 조합 요법
BR112019011350A2 (pt) 2016-12-01 2019-10-22 Glaxosmithkline Ip Dev Ltd terapia de combinação
KR20230037664A (ko) 2016-12-07 2023-03-16 아게누스 인코포레이티드 항-ctla-4 항체 및 이의 사용 방법
MA50948A (fr) 2016-12-07 2020-10-14 Agenus Inc Anticorps et procédés d'utilisation de ceux-ci
AU2017377036B2 (en) 2016-12-15 2022-06-23 Abbvie Biotherapeutics Inc. Anti-OX40 antibodies and their uses
CN110366557B (zh) 2016-12-23 2024-04-09 威特拉公司 结合多肽及其制备方法
US20180179490A1 (en) 2016-12-27 2018-06-28 Miltenyi Biotec Gmbh CELL COMPOSITION DEPLETED FROM TCRab and CD45RA POSITIVE CELLS
TW201825515A (zh) 2017-01-04 2018-07-16 美商伊繆諾金公司 Ｍｅｔ抗體以及其免疫結合物及用途
WO2018129284A1 (en) 2017-01-05 2018-07-12 The Johns Hopkins University Development of new monoclonal antibodies recognizing human prostate-specific membrane antigen (psma)
KR102679324B1 (ko) 2017-01-05 2024-06-28 네트리 파르마 네트린-1 간섭 약물과 면역 관문 억제제 약물의 조합 치료
JP7069476B2 (ja) 2017-01-06 2022-05-18 博奥信生物技▲術▼（南京）有限公司 ＥｒｂＢ２抗体およびその使用
GB201700345D0 (en) 2017-01-09 2017-02-22 F-Star Beta Ltd Conditional agonists of immune responses
WO2018132768A1 (en) 2017-01-13 2018-07-19 Sanna Pietro P Methods and compositions for treating hpa hyperactivity
EP3571223B1 (en) 2017-01-18 2024-09-18 Visterra, Inc. Antibody molecule-drug conjugates and uses thereof
CA3049047A1 (en) 2017-01-20 2018-07-26 Tayu Huaxia Biotech Medical Group Co., Ltd. Anti-pd-1 antibodies and uses thereof
CN112279918A (zh) 2017-01-24 2021-01-29 天境生物科技(上海)有限公司 Cd73抗体及其用途
WO2018140510A1 (en) 2017-01-25 2018-08-02 Biogen Ma Inc. Compositions and methods for treatment of stroke and other cns disorders
ES2912408T3 (es) 2017-01-26 2022-05-25 Novartis Ag Composiciones de CD28 y métodos para terapia con receptores quiméricos para antígenos
JP2020506700A (ja) 2017-01-31 2020-03-05 ノバルティス アーゲー 多重特異性を有するキメラｔ細胞受容体タンパク質を用いた癌の治療
EP3354278A1 (en) 2017-01-31 2018-08-01 Sanofi Neuronal cell protective effect of antibodies specific for the protofibrillar form of the beta-amyloid peptide
JOP20190189A1 (ar) 2017-02-02 2019-08-01 Amgen Res Munich Gmbh تركيبة صيدلانية ذات درجة حموضة منخفضة تتضمن بنيات جسم مضاد يستهدف الخلية t
US20190375847A1 (en) 2017-02-15 2019-12-12 Glaxosmithkline Intellectual Property Development Limited Combination treatment for cancer
US20200291089A1 (en) 2017-02-16 2020-09-17 Elstar Therapeutics, Inc. Multifunctional molecules comprising a trimeric ligand and uses thereof
EP3363459A1 (en) 2017-02-17 2018-08-22 Alexander Klimka Polypeptide epitopes of s. aureus and respective monoclonal antibodies for the treatment of infections and immune-diagnosis
EP3589662A4 (en) 2017-02-28 2020-12-30 Harpoon Therapeutics, Inc. INDUCTIBLE MONOVALENT ANTIGBINDING PROTEIN
CN110392697A (zh) 2017-03-02 2019-10-29 国家医疗保健研究所 对nectin-4具有特异性的抗体及其用途
EP3589319A4 (en) 2017-03-03 2021-07-14 Seagen Inc. COMPOUNDS INTERACTING WITH GLYCAN AND METHODS OF USE
CR20190468A (es) 2017-03-14 2019-12-17 Bioverativ Usa Inc Métodos para tratar enfermedades y trastornos mediados por completo
US10941203B2 (en) 2017-03-15 2021-03-09 Tsinghua University Anti-TrkB agonist antibodies binding to D5 domain of TrkB and methods of promoting neuronal survival in motor neuron injury, stroke or glaucoma
AU2018234628B2 (en) 2017-03-15 2023-07-20 Cue Biopharma, Inc. Methods for modulating an immune response
EP3596206A1 (en) 2017-03-16 2020-01-22 Pfizer Inc Tyrosine prototrophy
CA3051640A1 (en) 2017-03-16 2018-09-20 Innate Pharma Compositions and methods for treating cancer
TWI808963B (zh) 2017-03-22 2023-07-21 法商賽諾菲公司 使用人類化抗ｃｘｃｒ５抗體治療狼瘡
KR20190133005A (ko) 2017-03-24 2019-11-29 젠야쿠코교가부시키가이샤 항 IgM/B 세포 표면 항원 이중 특이성 항체
EP3601351A1 (en) 2017-03-27 2020-02-05 Celgene Corporation Methods and compositions for reduction of immunogenicity
JP6990355B2 (ja) 2017-03-30 2022-01-12 日油株式会社 ヘテロ二官能性単分散ポリエチレングリコール及びそれを用いた複合体
WO2018180914A1 (ja) 2017-03-30 2018-10-04 日油株式会社 自壊性アセタールリンカーを有する親水性ポリマー誘導体及びそれを用いた複合体
CN110461358A (zh) 2017-03-31 2019-11-15 公立大学法人奈良县立医科大学 可用于预防和/或治疗凝血因子ⅸ异常、包含代替凝血因子ⅷ的功能的多特异性抗原结合分子的药物组合物
WO2018187227A1 (en) 2017-04-03 2018-10-11 Concologie, Inc. Methods for treating cancer using ps-targeting antibodies with immuno-oncology agents
US10722589B2 (en) 2017-04-03 2020-07-28 Covagen Ag FGFR3 binding molecules
MX2019012223A (es) 2017-04-13 2019-12-09 Agenus Inc Anticuerpos anti-cd137 y metodos de uso de los mismos.
US20230227566A1 (en) 2017-04-14 2023-07-20 Gamamabs Pharma Amhrii-binding compounds for preventing or treating lung cancers
WO2018189379A1 (en) 2017-04-14 2018-10-18 Gamamabs Pharma Amhrii-binding compounds for preventing or treating cancers
AU2018256406A1 (en) 2017-04-19 2019-10-17 Marengo Therapeutics, Inc. Multispecific molecules and uses thereof
AU2018255938A1 (en) 2017-04-21 2019-10-31 Staten Biotechnology B.V. Anti-ApoC3 antibodies and methods of use thereof
WO2018199214A1 (ja) 2017-04-27 2018-11-01 中外製薬株式会社 薬物動態が改善された血液凝固第ｉｘ因子
WO2018196782A1 (en) 2017-04-27 2018-11-01 The University Of Hong Kong Use of hcn inhibitors for treatment of cancer
EP4328241A3 (en) 2017-04-28 2024-06-05 Marengo Therapeutics, Inc. Multispecific molecules comprising a non-immunoglobulin heterodimerization domain and uses thereof
US20200055948A1 (en) 2017-04-28 2020-02-20 Novartis Ag Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
HRP20230941T1 (hr) 2017-05-01 2023-11-24 Agenus Inc. Anti-tigit antitijela i postupci njihove primjene
US11851486B2 (en) 2017-05-02 2023-12-26 National Center Of Neurology And Psychiatry Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils
US11918650B2 (en) 2017-05-05 2024-03-05 Amgen Inc. Pharmaceutical composition comprising bispecific antibody constructs for improved storage and administration
WO2018206644A1 (en) 2017-05-11 2018-11-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Method of therapy selection for patient suffering from glioblastoma
JOP20190256A1 (ar) 2017-05-12 2019-10-28 Icahn School Med Mount Sinai فيروسات داء نيوكاسل واستخداماتها
JP7090347B2 (ja) 2017-05-12 2022-06-24 ハープーン セラピューティクス，インク． メソテリン結合タンパク質
KR20200026810A (ko) 2017-05-12 2020-03-11 하푼 테라퓨틱스, 인크. Msln 표적화 삼중 특이적 단백질 및 사용 방법
US11390683B2 (en) 2017-05-18 2022-07-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-mesothelin polypeptides and proteins
CN110753703B (zh) 2017-05-23 2024-04-09 德国亥姆霍兹慕尼黑中心健康与环境研究中心（有限公司） 新的cd73抗体、其制备和用途
WO2018222689A1 (en) 2017-05-31 2018-12-06 Stcube & Co., Inc. Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof
US20210246227A1 (en) 2017-05-31 2021-08-12 Elstar Therapeutics, Inc. Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof
JP2020522512A (ja) 2017-05-31 2020-07-30 ストキューブ アンド シーオー．， インコーポレイテッド Ｂｔｎ１ａ１に免疫特異的に結合する抗体及び分子を用いて癌を治療する方法
US11542331B2 (en) 2017-06-06 2023-01-03 Stcube & Co., Inc. Methods of treating cancer using antibodies and molecules that bind to BTN1A1 or BTN1A1-ligands
WO2018226685A2 (en) 2017-06-06 2018-12-13 Dana-Farber Cancer Institute, Inc. Methods for sensitizing cancer cells to t cell-mediated killing by modulating molecular pathways
EP3634999A1 (en) 2017-06-07 2020-04-15 Philogen S.p.A. Vascular endothelial growth factor/anti-fibronectin antibody fusion proteins
CN110831971A (zh) 2017-06-09 2020-02-21 葛兰素史克知识产权开发有限公司 用icos激动剂和ox40激动剂治疗癌症的组合疗法
JP2020522555A (ja) 2017-06-09 2020-07-30 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 組み合わせ療法
CN110709423A (zh) 2017-06-09 2020-01-17 葛兰素史克知识产权开发有限公司 用icos激动剂和ox40激动剂治疗癌症的组合疗法
WO2018232020A1 (en) 2017-06-13 2018-12-20 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
WO2018237173A1 (en) 2017-06-22 2018-12-27 Novartis Ag ANTIBODY MOLECULES DIRECTED AGAINST CD73 AND CORRESPONDING USES
WO2019006007A1 (en) 2017-06-27 2019-01-03 Novartis Ag POSOLOGICAL REGIMES FOR ANTI-TIM3 ANTIBODIES AND USES THEREOF
US11613588B2 (en) 2017-06-28 2023-03-28 The Rockefeller University Anti-mertk agonistic antibodies and uses thereof
WO2019005503A1 (en) 2017-06-29 2019-01-03 Rutgers, The State University Of New Jersey COMPOSITIONS AND METHODS TARGETING G12 SIGNALING FOR BRONCHODILATORY THERAPY
EP3574020B1 (en) 2017-07-18 2024-05-15 The University of British Columbia Antibodies to amyloid beta
EP3431496A1 (en) 2017-07-19 2019-01-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Anti- isoasp7 amyloid beta antibodies and uses thereof
EP3655023A1 (en) 2017-07-20 2020-05-27 Novartis AG Dosage regimens of anti-lag-3 antibodies and uses thereof
WO2019020480A1 (en) 2017-07-24 2019-01-31 INSERM (Institut National de la Santé et de la Recherche Médicale) ANTIBODIES AND PEPTIDES FOR TREATING HCMV RELATED DISEASES
CA3107625A1 (en) 2017-07-28 2019-01-31 Biouniversa S.R.L. Anti-bag3 antibodies as therapeutic reagent in cardiovascular diseases
US11680110B2 (en) 2017-07-31 2023-06-20 Hoffmann-La Roche Inc. Three-dimensional structure-based humanization method
WO2019035938A1 (en) 2017-08-16 2019-02-21 Elstar Therapeutics, Inc. MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF
AU2018323470A1 (en) 2017-08-28 2020-03-19 Angiex, Inc. Anti-TM4SF1 antibodies and methods of using same
JP2020532991A (ja) 2017-09-07 2020-11-19 オーガスタ ユニバーシティ リサーチ インスティテュート，インコーポレーテッド プログラム細胞死タンパク質１に対する抗体
WO2019053613A2 (en) 2017-09-14 2019-03-21 Glaxosmithkline Intellectual Property Development Limited POLY THERAPY FOR THE TREATMENT OF CANCER
US20200255785A1 (en) 2017-09-15 2020-08-13 Bristol-Myers Squibb Company Online biomass capacitance monitoring during large scale production of polypeptides of interest
AU2018335955A1 (en) 2017-09-21 2020-03-26 Centre National De La Recherche Scientifique - Cnrs - Antibodies having specificity for BTN2 and uses thereof
US10610585B2 (en) 2017-09-26 2020-04-07 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and compositions for treating and preventing HIV
WO2019070726A1 (en) 2017-10-02 2019-04-11 Visterra, Inc. CD73 BINDING ANTIBODY MOLECULES AND USES THEREOF
EP3461841B1 (en) 2017-10-02 2019-09-11 Certest Biotec, S.L. Anti-dps antibodies and test devices for the detection of bacteria of the genus campylobacter
KR20210027230A (ko) 2017-10-04 2021-03-10 옵코 파마슈티칼스, 엘엘씨 암의 개인 맞춤형 치료에 관한 물품 및 방법
EP3694552A1 (en) 2017-10-10 2020-08-19 Tilos Therapeutics, Inc. Anti-lap antibodies and uses thereof
WO2019074124A1 (en) 2017-10-12 2019-04-18 Keio University MONOCLONAL ANTI-AQP3 ANTIBODY BINDING SPECIFICALLY TO THE EXTRACELLULAR DOMAIN OF AQUAPORIN 3 (AQP3) AND USE THEREOF
SG11202003359UA (en) 2017-10-13 2020-05-28 Harpoon Therapeutics Inc Trispecific proteins and methods of use
EA202090739A1 (ru) 2017-10-13 2020-09-07 Харпун Терапьютикс, Инк. Белки, связывающие антиген созревания в-клеток
AU2018353432A1 (en) 2017-10-19 2020-04-23 Debiopharm International S.A. Combination product for the treatment of cancer
JP7235249B2 (ja) 2017-10-20 2023-03-08 学校法人兵庫医科大学 抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物
TW201922294A (zh) 2017-10-31 2019-06-16 美商伊繆諾金公司 抗體-藥物結合物與阿糖胞苷之組合治療
WO2019087115A1 (en) 2017-10-31 2019-05-09 Staten Biotechnology B.V. Anti-apoc3 antibodies and methods of use thereof
AU2018364630A1 (en) 2017-11-09 2020-05-21 Pinteon Therapeutics Inc. Methods and compositions for the generation and use of humanized conformation-specific phosphorylated tau antibodies
AU2018368431B2 (en) 2017-11-14 2024-03-21 Arcellx, Inc. Multifunctional immune cell therapies
WO2019099838A1 (en) 2017-11-16 2019-05-23 Novartis Ag Combination therapies
US11401345B2 (en) 2017-11-27 2022-08-02 Purdue Pharma L.P. Humanized antibodies targeting human tissue factor
JP7266532B2 (ja) 2017-11-28 2023-04-28 中外製薬株式会社 リガンド結合活性が調整可能なリガンド結合分子
AU2018375787B2 (en) 2017-11-30 2023-02-23 Ladrx Corporation Albumin-binding prodrugs of auristatin E derivatives
BR112020010989A2 (pt) 2017-11-30 2020-11-17 Centurion Biopharma Corporation sistemas de distribuição de droga à base de maitansinoide
WO2019106605A1 (en) 2017-12-01 2019-06-06 Board Of Regents, The University Of Texas System Combination treatment for cancer
WO2019110706A1 (en) 2017-12-08 2019-06-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the risk of developing a sepsis or a systemic inflammatory response syndrome (sirs)
US20200377571A1 (en) 2017-12-08 2020-12-03 Elstar Therapeutics, Inc. Multispecific molecules and uses thereof
SG11202004273YA (en) 2017-12-11 2020-06-29 Amgen Inc Continuous manufacturing process for bispecific antibody products
EP3502139A1 (en) 2017-12-19 2019-06-26 Philogen S.p.A. Antibodies to tumour antigens
US11548948B2 (en) 2017-12-19 2023-01-10 F-Star Therapeutics Limited FC binding fragments comprising a PD-L1 antigen-binding site
EP3728639B1 (en) 2017-12-20 2023-05-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Method of selection of an ire1-inhibitor therapy for patient suffering from cancer
TWI817974B (zh) 2017-12-28 2023-10-11 日商中外製藥股份有限公司 細胞毒性誘導治療劑
UY38041A (es) 2017-12-29 2019-06-28 Amgen Inc Construcción de anticuerpo biespecífico dirigida a muc17 y cd3
BR112020013405A2 (pt) 2018-01-25 2020-12-01 Acm Biolabs Pte Ltd. polimerossomas compreendendo um antígeno encapsulado solúvel, assim como métodos de sua fabricação e uso
JP7458790B2 (ja) 2018-01-31 2024-04-01 元一 加藤 Ｉｌ－６阻害剤を含有する喘息の治療剤
WO2019158512A1 (en) 2018-02-13 2019-08-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the prognosis and the treatment of glioblastoma
US20210085715A1 (en) 2018-02-23 2021-03-25 Cartherics Pty. Ltd. T cell disease treatment targeting tag-72
WO2019169229A1 (en) 2018-03-01 2019-09-06 Nextcure, Inc. Klrg1 binding compositions and methods of use thereof
TW202003555A (zh) 2018-03-07 2020-01-16 英商葛蘭素史克智慧財產發展有限公司 用於純化重組多肽之方法
TW202000891A (zh) 2018-03-07 2020-01-01 英商葛蘭素史克智慧財產發展有限公司 純化抗體之方法
CA3093694A1 (en) 2018-03-12 2019-09-19 Memorial Sloan Kettering Cancer Center Bispecific binding agents and uses thereof
CA3093645A1 (en) 2018-03-13 2019-09-19 Nof Corporation Heterobifunctional compound having monodispersed polyethylene glycol in main chain and side chain
WO2019178362A1 (en) 2018-03-14 2019-09-19 Elstar Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
US20210009711A1 (en) 2018-03-14 2021-01-14 Elstar Therapeutics, Inc. Multifunctional molecules and uses thereof
CN111902160A (zh) 2018-03-16 2020-11-06 百时美施贵宝公司 蛋白质生产期间的代谢酶活性和二硫键还原
GB201804701D0 (en) 2018-03-23 2018-05-09 Gammadelta Therapeutics Ltd Lymphocytes expressing heterologous targeting constructs
ES2950740T3 (es) 2018-03-26 2023-10-13 Glycanostics S R O Medios y métodos para el glicoperfilado de una proteína
AU2019242520A1 (en) 2018-03-30 2020-10-29 Toray Industries, Inc. Pharmaceutical composition for treatment and/or prevention of cancer
KR20200139219A (ko) 2018-04-02 2020-12-11 브리스톨-마이어스 스큅 컴퍼니 항-trem-1 항체 및 이의 용도
US20210228729A1 (en) 2018-04-12 2021-07-29 Mediapharma S.R.L. Lgals3bp antibody-drug-conjugate and its use for the treatment of cancer
US20210147547A1 (en) 2018-04-13 2021-05-20 Novartis Ag Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof
US20210047405A1 (en) 2018-04-27 2021-02-18 Novartis Ag Car t cell therapies with enhanced efficacy
WO2019207159A1 (en) 2018-04-27 2019-10-31 Fondazione Ebri Rita Levi-Montalcini Antibody directed against a tau-derived neurotoxic peptide and uses thereof
WO2019213282A1 (en) 2018-05-01 2019-11-07 Novartis Ag Biomarkers for evaluating car-t cells to predict clinical outcome
WO2019217450A1 (en) 2018-05-08 2019-11-14 Rhode Island Hospital Anti-chi3l1 antibodies for the detection and/or treatment of nonalcoholic fattly liver disease/nonalcoholic steatohepatitis and subsequent complications
JP7530638B2 (ja) 2018-05-10 2024-08-08 ニューラクル サイエンス カンパニー リミテッド 配列類似性１９、メンバーａ５抗体を有する抗ファミリー及びその使用方法
CN112639474A (zh) 2018-05-14 2021-04-09 卑尔根生物股份公司 血清生物标志物
WO2019222130A1 (en) 2018-05-15 2019-11-21 Immunogen, Inc. Combination treatment with antibody-drug conjugates and flt3 inhibitors
US20210196568A1 (en) 2018-05-21 2021-07-01 Chugai Seiyaku Kabushiki Kaisha Lyophilized formulation sealed in glass container
EP3801769A1 (en) 2018-05-25 2021-04-14 Novartis AG Combination therapy with chimeric antigen receptor (car) therapies
CA3101553A1 (en) 2018-05-31 2019-12-05 Glaxosmithkline Intellectual Property Development Limited Combination of a type ii protein arginine methyltransferase inhibitor and an icos binding protein to treat cancer
US20210260033A1 (en) 2018-05-31 2021-08-26 Glaxosmithkline Intellectual Property Development Limited Combined therapy with icos binding proteins and argininemethyltransferase inhibitors
GB201808927D0 (en) 2018-05-31 2018-07-18 Institute Of Cancer Res Royal Cancer Hospital Materials and methods for monitoring the development of resistance of cancers to treatment
EP3802611A2 (en) 2018-06-01 2021-04-14 Novartis AG Binding molecules against bcma and uses thereof
JP7457661B2 (ja) 2018-06-04 2024-03-28 バイオジェン・エムエイ・インコーポレイテッド 低減したエフェクター機能を有する抗ｖｌａ－４抗体
JP7543144B2 (ja) 2018-06-05 2024-09-02 アムジエン・インコーポレーテツド 抗体依存性細胞貪食の調節
US11830582B2 (en) 2018-06-14 2023-11-28 University Of Miami Methods of designing novel antibody mimetics for use in detecting antigens and as therapeutic agents
WO2019243252A1 (en) 2018-06-18 2019-12-26 Innate Pharma Compositions and methods for treating cancer
CA3104295A1 (en) 2018-06-19 2019-12-26 Atarga, Llc Antibody molecules to complement component 5 and uses thereof
WO2019244107A1 (en) 2018-06-21 2019-12-26 Daiichi Sankyo Company, Limited Compositions including cd3 antigen binding fragments and uses thereof
EA202190092A1 (ru) 2018-06-21 2021-05-18 Юманити Терапьютикс, Инк. Композиции и способы лечения и профилактики неврологических расстройств
EP3814369A1 (en) 2018-06-29 2021-05-05 Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis Tweak-receptor agonists for use in combination with immunotherapy of a cancer
WO2020003210A1 (en) 2018-06-29 2020-01-02 Kangwon National University University-Industry Cooperation Foundation Anti-l1cam antibodies and uses thereof
US11845797B2 (en) 2018-07-03 2023-12-19 Marengo Therapeutics, Inc. Anti-TCR antibody molecules and uses thereof
WO2020014306A1 (en) 2018-07-10 2020-01-16 Immunogen, Inc. Met antibodies and immunoconjugates and uses thereof
GB201811450D0 (en) 2018-07-12 2018-08-29 F Star Delta Ltd Mesothelin and CD137 binding molecules
US20220049007A1 (en) 2018-07-12 2022-02-17 F-Star Beta Limited Antibody molecules that bind pd-l1 and cd137
GB201811410D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd OX40 Binding molecules
GB201811415D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd Anti-Mesothelin Anti bodies
GB201811408D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd CD137 Binding Molecules
GB201811403D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd Antibody molecules
MX2021000399A (es) 2018-07-12 2021-05-27 F Star Therapeutics Ltd Moleculas de anticuerpo que se unen a cd137 y ox40.
GB201811404D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd Anti-CD137 Antibodies
CN112740043A (zh) 2018-07-20 2021-04-30 皮埃尔法布雷医药公司 Vista受体
CN112739340A (zh) 2018-07-23 2021-04-30 美真达治疗公司 抗cd5抗体药物缀合物(adc)在同种异体细胞疗法中的用途
WO2020021465A1 (en) 2018-07-25 2020-01-30 Advanced Accelerator Applications (Italy) S.R.L. Method of treatment of neuroendocrine tumors
WO2020022499A1 (ja) 2018-07-27 2020-01-30 国立大学法人大阪大学 老化の抑制、加齢性の疾患もしくは症状の予防、改善、もしくは治療、または寿命の延長のための組成物
US20210301017A1 (en) 2018-07-30 2021-09-30 Amgen Research (Munich) Gmbh Prolonged administration of a bispecific antibody construct binding to cd33 and cd3
CA3107192A1 (en) 2018-08-03 2020-02-06 Amgen Research (Munich) Gmbh Antibody constructs for cldn18.2 and cd3
WO2020030570A1 (en) 2018-08-06 2020-02-13 Glaxosmithkline Intellectual Property Development Limited Combinations of an ox40 antibody and a tlr4 modulator and uses thereof
WO2020031087A1 (en) 2018-08-06 2020-02-13 Glaxosmithkline Intellectual Property Development Limited Combination therapy
WO2020030571A1 (en) 2018-08-06 2020-02-13 Glaxosmithkline Intellectual Property Development Limited Combinations of a pd-1 antibody and a tlr4 modulator and uses thereof
JP2021534779A (ja) 2018-08-27 2021-12-16 アフィメッド ゲゼルシャフト ミット ベシュレンクテル ハフツンク 抗体構築物がプレロードされた凍結保存ｎｋ細胞
EP3844192A1 (en) 2018-08-30 2021-07-07 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
JP2022500371A (ja) 2018-09-11 2022-01-04 アムジエン・インコーポレーテツド 抗体依存性細胞介在性細胞傷害の調節方法
WO2020053325A1 (en) 2018-09-12 2020-03-19 Acm Biolabs Pte Ltd Polymersomes comprising a covalently bound antigen as well as methods of making and uses thereof
EP3849565A4 (en) 2018-09-12 2022-12-28 Fred Hutchinson Cancer Research Center REDUCING CD33 EXPRESSION FOR SELECTIVE PROTECTION OF THERAPEUTIC CELLS
GB201815041D0 (en) 2018-09-14 2018-10-31 Scancell Ltd Epitopes
WO2020061210A1 (en) 2018-09-18 2020-03-26 Merrimack Pharmaceuticals, Inc. Anti-tnfr2 antibodies and uses thereof
EP3854875A4 (en) 2018-09-21 2022-07-06 National University Corporation Tokyo Medical and Dental University HUMAN MONOCLONAL ANTIBODY BINDING SPECIFICALLY TO HUMAN HMGB1, AND PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OR PREVENTION OF ALZHEIMER'S DISEASE CONTAINING SUCH HUMAN MONOCLONAL ANTIBODY
CA3114038A1 (en) 2018-09-25 2020-04-02 Harpoon Therapeutics, Inc. Dll3 binding proteins and methods of use
AU2019346645A1 (en) 2018-09-27 2021-04-29 Marengo Therapeutics, Inc. CSF1R/CCR2 multispecific antibodies
WO2020069409A1 (en) 2018-09-28 2020-04-02 Novartis Ag Cd19 chimeric antigen receptor (car) and cd22 car combination therapies
WO2020065594A1 (en) 2018-09-28 2020-04-02 Kyowa Kirin Co., Ltd. Il-36 antibodies and uses thereof
EP3856779A1 (en) 2018-09-28 2021-08-04 Novartis AG Cd22 chimeric antigen receptor (car) therapies
CN112703204A (zh) 2018-09-28 2021-04-23 安进公司 针对可溶性bcma的抗体
CN112969503A (zh) 2018-10-03 2021-06-15 斯塔滕生物技术有限公司 对人类和食蟹猕猴apoc3具有特异性的抗体和其使用方法
EP3863722A2 (en) 2018-10-10 2021-08-18 Tilos Theapeutics, Inc. Anti-lap antibody variants and uses thereof
SG11202103275YA (en) 2018-10-11 2021-04-29 Amgen Inc Downstream processing of bispecific antibody constructs
MX2021004603A (es) 2018-10-22 2021-09-08 Glaxosmithkline Ip Dev Ltd Dosificacion.
WO2020092455A2 (en) 2018-10-29 2020-05-07 The Broad Institute, Inc. Car t cell transcriptional atlas
EP3877413A1 (en) 2018-11-06 2021-09-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of acute myeloid leukemia by eradicating leukemic stem cells
EP3880706A1 (en) 2018-11-12 2021-09-22 MediaPharma S.r.l. Bispecific antibodies directed against human 90k and either endosialin or her3
CA3121884A1 (en) 2018-12-06 2020-06-11 Pfizer Inc. Cells with reduced inhibitor production and methods of use thereof
WO2020118293A2 (en) 2018-12-07 2020-06-11 Georgia Tech Research Corporation Antibodies that bind to natively folded myocilin
KR20210148076A (ko) 2018-12-11 2021-12-07 큐32 바이오 인크. 보체 연관 질환을 위한 융합 단백질 작제물
US20220064260A1 (en) 2018-12-14 2022-03-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Isolated mhc-derived human peptides and uses thereof for stimulating and activating the suppressive function of cd8+cd45rclow tregs
TW202031684A (zh) 2018-12-20 2020-09-01 日商協和麒麟股份有限公司 Fn14抗體及其用途
JP2022514280A (ja) 2018-12-20 2022-02-10 ノバルティス アーゲー Ｍｄｍ２阻害剤のための延長低用量レジメン
US11680105B2 (en) 2019-01-17 2023-06-20 Regents Of The University Of Minnesota Antibody fragments for detecting cancer and methods of use
CA3127025A1 (en) 2019-01-18 2020-07-23 Janssen Biotech, Inc. Gprc5d chimeric antigen receptors and cells expressing the same
JPWO2020153467A1 (ja) 2019-01-24 2021-12-02 中外製薬株式会社 新規がん抗原及びそれらの抗原に対する抗体
US20220125754A1 (en) 2019-01-29 2022-04-28 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Treating the causative agent in adhesiogenesis
GB201901305D0 (en) 2019-01-30 2019-03-20 Immunocore Ltd Specific binding molecules
AU2020214412A1 (en) 2019-02-01 2021-08-12 Glaxosmithkline Intellectual Property Development Limited Belantamab mafodotin in combination with pembrolizumab for treating cancer
EP3912992A4 (en) 2019-02-04 2022-11-23 National University Corporation Ehime University CAR LIBRARY AND MANUFACTURING PROCESSES FOR SCFV
WO2020167912A1 (en) 2019-02-13 2020-08-20 The Brigham And Women's Hospital, Inc. Anti-peripheral lymph node addressin antibodies and uses thereof
US10871640B2 (en) 2019-02-15 2020-12-22 Perkinelmer Cellular Technologies Germany Gmbh Methods and systems for automated imaging of three-dimensional objects
WO2020169472A2 (en) 2019-02-18 2020-08-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of inducing phenotypic changes in macrophages
CA3130508A1 (en) 2019-02-21 2020-08-27 Marengo Therapeutics, Inc. Antibody molecules that bind to nkp30 and uses thereof
EP3927745A1 (en) 2019-02-21 2021-12-29 Marengo Therapeutics, Inc. Multifunctional molecules that bind to t cells and uses thereof to treat autoimmune disorders
WO2020172596A1 (en) 2019-02-21 2020-08-27 Elstar Therapeutics, Inc. Anti-tcr antibody molecules and thereof
WO2020172571A1 (en) 2019-02-21 2020-08-27 Elstar Therapeutics, Inc. Multifunctional molecules that bind to t cell related cancer cells and uses thereof
GB2599229B (en) 2019-02-21 2024-04-24 Marengo Therapeutics Inc Multifunctional molecules that bind to calreticulin and uses thereof
US11639388B2 (en) 2019-02-22 2023-05-02 Wuhan Yzy Biopharma Co., Ltd. CD3 antigen binding fragment and application thereof
CA3131033A1 (en) 2019-02-22 2020-08-27 Wuhan Yzy Biopharma Co., Ltd. Modified fc fragment, antibodies containing the same and use thereof
US20220088075A1 (en) 2019-02-22 2022-03-24 The Trustees Of The University Of Pennsylvania Combination therapies of egfrviii chimeric antigen receptors and pd-1 inhibitors
JP2022522344A (ja) 2019-02-26 2022-04-18 インスピアーナ， インコーポレイテッド 高親和性抗ｍｅｒｔｋ抗体およびその使用
CN113508140A (zh) 2019-02-28 2021-10-15 学校法人顺天堂 与切断型的突变型Calreticulin结合的抗体以及骨髄增殖性肿瘤的诊断、预防或治疗药
CA3131953A1 (en) 2019-03-01 2020-09-10 Merrimack Pharmaceuticals, Inc. Anti-tnfr2 antibodies and uses thereof
EP3943108A4 (en) 2019-03-19 2023-01-04 Chugai Seiyaku Kabushiki Kaisha ANTIGEN-BINDING MOLECULE CONTAINING AN ANTIGEN-BINDING DOMAIN WHOSE ANTIGEN-BINDING ACTIVITY IS ALTERED DEPENDING ON THE MTA, AND BANK FOR OBTAINING SUCH ANTIGEN-BINDING DOMAIN
SG11202109932WA (en) 2019-03-20 2021-10-28 Imcheck Therapeutics Sas Antibodies having specificity for btn2 and uses thereof
JP2022526334A (ja) 2019-03-25 2022-05-24 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 新たなタウ種を標的化することによるタウオパチー障害の処置の方法
CN113874392A (zh) 2019-03-28 2021-12-31 丹尼斯科美国公司 工程化抗体
EP3946593A1 (en) 2019-03-29 2022-02-09 Atarga, LLC Anti fgf23 antibody
CA3135032A1 (en) 2019-04-03 2020-10-08 Genzyme Corporation Anti-alpha beta tcr binding polypeptides with reduced fragmentation
SG11202110986YA (en) 2019-04-10 2021-11-29 Chugai Pharmaceutical Co Ltd Method for purifying fc region-modified antibody
AU2020271123A1 (en) 2019-04-10 2021-11-25 Elevatebio Technologies, Inc. FLT3-specific chimeric antigen receptors and methods of using the same
KR20220019670A (ko) 2019-04-17 2022-02-17 고쿠리츠다이가쿠호진 히로시마다이가쿠 Il-6 저해제 및 ccr2 저해제를 조합하여 투여하는 것을 특징으로 하는 비뇨기암의 치료제
WO2020213084A1 (en) 2019-04-17 2020-10-22 Keio University Anti aqp3 monoclonal antibody specifically binding to extracellular domain of aquaporin 3 (aqp3) and use thereof
JP2022529344A (ja) 2019-04-18 2022-06-21 エイシー イミューン ソシエテ アノニム 治療及び診断のための新規分子
CN114007642A (zh) 2019-04-30 2022-02-01 森迪生物科学公司 嵌合受体及其使用方法
EP3962529A4 (en) 2019-04-30 2023-11-01 Dana-Farber Cancer Institute, Inc. METHOD FOR CANCER TREATMENT USING ANTI-CX3CR1 AND IMMUNE CHECKPOINT BLOCKING REAGENTS COMBINATIONS
GB201906578D0 (en) 2019-05-09 2019-06-26 Cancer Research Tech Ltd Detection of fusion protein
WO2020236797A1 (en) 2019-05-21 2020-11-26 Novartis Ag Variant cd58 domains and uses thereof
UY38701A (es) 2019-05-21 2020-12-31 Novartis Ag Moléculas de unión a cd19, conjugados, composiciones que las comprenden y usos de las mismas
KR20220012894A (ko) 2019-05-24 2022-02-04 사노피 전신 경화증의 치료 방법
BR112021023735A2 (pt) 2019-06-05 2022-01-04 Chugai Pharmaceutical Co Ltd Molécula de ligação de sítio de clivagem de anti-corpo
MX2021014644A (es) 2019-06-13 2022-04-06 Amgen Inc Control de perfusion basado en biomasa automatizado en la fabricacion de productos biologicos.
CN114269786A (zh) 2019-06-17 2022-04-01 威特拉公司 Cd138人源化抗体分子及其用途
MA56397A (fr) 2019-06-26 2022-05-04 Glaxosmithkline Ip Dev Ltd Protéines de liaison à l'il1rap
GB201909393D0 (en) 2019-06-28 2019-08-14 Gen2 Neuroscience Ltd Tau epitope and binding molecules
EP3994270A1 (en) 2019-07-02 2022-05-11 Fred Hutchinson Cancer Research Center Recombinant ad35 vectors and related gene therapy improvements
GB2585252A (en) 2019-07-05 2021-01-06 Gen2 Neuroscience Ltd Tau epitope and binding molecules
CA3146381A1 (en) 2019-07-11 2021-01-14 Wuhan Yzy Biopharma Co., Ltd. Tetravalent symmetric bispecific antibodies
EP3999091A1 (en) 2019-07-15 2022-05-25 MedImmune Limited Tripartite systems for protein dimerization and methods of use
AU2020322221A1 (en) 2019-07-26 2022-03-24 Janssen Biotech, Inc. Anti-hK2 chimeric antigen receptor (CAR)
MX2022001061A (es) 2019-07-26 2022-02-14 Visterra Inc Agentes de interleuquina-2 y usos de los mismos.
EP4004050A2 (en) 2019-07-30 2022-06-01 QLSF Biotherapeutics Inc. Multispecific binding compound that bind to lfrrc15 and cd3
WO2021018941A1 (en) 2019-07-31 2021-02-04 Glaxosmithkline Intellectual Property Development Limited Methods of treating cancer
GB201910899D0 (en) 2019-07-31 2019-09-11 Scancell Ltd Binding members
JP2022543259A (ja) 2019-08-02 2022-10-11 オレガ・バイオテック 新規ｉｌ－１７ｂ抗体
CN114867751A (zh) 2019-08-12 2022-08-05 阿帕特夫研究和发展有限公司 4-1bb和ox40结合蛋白及相关组合物和方法、抗-4-1bb抗体、抗-ox40抗体
GB201912030D0 (en) 2019-08-21 2019-10-02 Cancer Research Tech Ltd Binding molecules
WO2021035170A1 (en) 2019-08-21 2021-02-25 Precision Biosciences, Inc. Compositions and methods for tcr reprogramming using fusion proteins
BR112022003740A2 (pt) 2019-08-30 2022-05-31 Agenus Inc Anticorpos anti-cd96 e métodos de uso dos mesmos
GB201912657D0 (en) 2019-09-03 2019-10-16 Scancell Ltd Binding members
CN117683133A (zh) 2019-09-03 2024-03-12 百奥泰生物制药股份有限公司 一种抗tigit免疫抑制剂及应用
EP4025303A1 (en) 2019-09-04 2022-07-13 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) Herv inhibitors for use in treating tauopathies
WO2021046289A1 (en) 2019-09-06 2021-03-11 Glaxosmithkline Intellectual Property Development Limited Dosing regimen for the treatment of cancer with an anti icos agonistic antibody and ipilimumab
GB201912882D0 (en) 2019-09-06 2019-10-23 Scancell Ltd Ssea-4 binding members
WO2021043961A1 (en) 2019-09-06 2021-03-11 Glaxosmithkline Intellectual Property Development Limited Dosing regimen for the treatment of cancer with an anti icos agonistic antibody and chemotherapy
MX2022002981A (es) 2019-09-10 2022-04-06 Amgen Inc Metodo de purificacion para polipeptidos de union a antigeno biespecificos con capacidad de union dinamica de captura de proteina l mejorada.
EP3792632A1 (en) 2019-09-16 2021-03-17 Vito NV Immunotherapy markers
CN114450324B (zh) 2019-09-26 2024-02-27 日油株式会社 具有肽连接子的异双官能单分散聚乙二醇
EP4041767A1 (en) 2019-09-26 2022-08-17 StCube & Co. Antibodies specific to glycosylated ctla-4 and methods of use thereof
US20220324962A1 (en) 2019-09-27 2022-10-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-müllerian inhibiting substance antibodies and uses thereof
WO2021058729A1 (en) 2019-09-27 2021-04-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-müllerian inhibiting substance type i receptor antibodies and uses thereof
JP2022552282A (ja) 2019-10-09 2022-12-15 エスティーキューブ アンド カンパニー グリコシル化ｌａｇ３に対して特異的な抗体およびその使用方法
GB201915163D0 (en) 2019-10-18 2019-12-04 Univ Southampton Cancer vaccine
EP4048285A1 (en) 2019-10-21 2022-08-31 Novartis AG Tim-3 inhibitors and uses thereof
US20240301053A1 (en) 2019-10-21 2024-09-12 Novartis Ag Combination therapies with venetoclax and tim-3 inhibitors
EP3812008A1 (en) 2019-10-23 2021-04-28 Gamamabs Pharma Amh-competitive antagonist antibody
WO2021097344A1 (en) 2019-11-13 2021-05-20 Amgen Inc. Method for reduced aggregate formation in downstream processing of bispecific antigen-binding molecules
JP2023502652A (ja) 2019-11-18 2023-01-25 ヤンセン バイオテツク，インコーポレーテツド 抗ｃｄ７９キメラ抗原受容体、ｃａｒ－ｔ細胞、及びそれらの使用
EP3825330A1 (en) 2019-11-19 2021-05-26 International-Drug-Development-Biotech Anti-cd117 antibodies and methods of use thereof
US20230037414A1 (en) 2019-11-22 2023-02-09 INSERM (Institut National de la Santé et de la Recherche Médicale Inhibitors of adrenomedullin for the treatment of acute myeloid leukemia by eradicating leukemic stem cells
CA3162559A1 (en) 2019-11-25 2021-06-03 Griffith University Immunogenic protein against gonococcal infection
JP2023504699A (ja) 2019-12-04 2023-02-06 エイシー イミューン ソシエテ アノニム 治療および診断のための新規な分子
US11897950B2 (en) 2019-12-06 2024-02-13 Augusta University Research Institute, Inc. Osteopontin monoclonal antibodies
WO2021119012A1 (en) 2019-12-09 2021-06-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services ANTIBODIES TARGETING CELL SURFACE DEPOSITED COMPLEMENT PROTEIN C3d AND USE THEREOF
US20230040928A1 (en) 2019-12-09 2023-02-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies having specificity to her4 and uses thereof
WO2021116277A1 (en) 2019-12-10 2021-06-17 Institut Pasteur New antibody blocking human fcgriiia and fcgriiib
CA3164129A1 (en) 2019-12-20 2021-06-24 Amgen Inc. Mesothelin-targeted cd40 agonistic multispecific antibody constructs for the treatment of solid tumors
CN115175937A (zh) 2019-12-20 2022-10-11 诺华股份有限公司 用于治疗骨髓纤维化和骨髓增生异常综合征的抗TIM-3抗体MBG453和抗TGF-β抗体NIS793与或不与地西他滨或抗PD-1抗体斯巴达珠单抗的组合
WO2021130383A1 (en) 2019-12-27 2021-07-01 Affimed Gmbh Method for the production of bispecific fcyriii x cd30 antibody construct
TW202138388A (zh) 2019-12-30 2021-10-16 美商西根公司 以非海藻糖苷化抗－ｃｄ７０抗體治療癌症之方法
WO2021138407A2 (en) 2020-01-03 2021-07-08 Marengo Therapeutics, Inc. Multifunctional molecules that bind to cd33 and uses thereof
JP2023509760A (ja) 2020-01-08 2023-03-09 シンシス セラピューティクス，インコーポレイテッド Ａｌｋ５阻害剤複合体およびその使用
WO2021140173A1 (en) 2020-01-10 2021-07-15 Biouniversa S.R.L. Methods and uses for treating fibrotic solid tumors with bags inhibitors
TW202140553A (zh) 2020-01-13 2021-11-01 美商威特拉公司 C5ar1抗體分子及其用途
CN114980902A (zh) 2020-01-17 2022-08-30 诺华股份有限公司 用于治疗骨髓增生异常综合征或慢性粒单核细胞白血病的包含tim-3抑制剂和低甲基化药物的组合
WO2021150824A1 (en) 2020-01-22 2021-07-29 Amgen Research (Munich) Gmbh Combinations of antibody constructs and inhibitors of cytokine release syndrome and uses thereof
BR112022014562A2 (pt) 2020-01-28 2022-09-13 Glaxosmithkline Ip Dev Ltd Tratamentos de combinação, usos e métodos dos mesmos
CN115397848A (zh) 2020-02-05 2022-11-25 拉利玛生物医药公司 Tat肽结合蛋白及其用途
BR112022016550A2 (pt) 2020-02-21 2022-11-16 Harpoon Therapeutics Inc Proteínas de ligação a flt3 e métodos de uso
TW202200209A (zh) 2020-02-28 2022-01-01 美商健臻公司 用於優化之藥物接合之經修飾的結合多肽
WO2021175954A1 (en) 2020-03-04 2021-09-10 Imcheck Therapeutics Sas Antibodies having specificity for btnl8 and uses thereof
CA3174103A1 (en) 2020-03-06 2021-09-10 Go Therapeutics, Inc. Anti-glyco-cd44 antibodies and their uses
US11896619B2 (en) 2020-03-10 2024-02-13 Massachusetts Institute Of Technology Compositions and methods for immunotherapy of NPM1c-positive cancer
KR20220153621A (ko) 2020-03-12 2022-11-18 도레이 카부시키가이샤 암의 치료 및/또는 예방을 위한 의약품
CA3175129A1 (en) 2020-03-12 2021-09-19 Toray Industries, Inc. Medicament for treatment and/or prevention of cancer
US20230159635A1 (en) 2020-03-12 2023-05-25 Toray Industries, Inc. Medicament for treatment and/or prevention of cancer
US20230165957A1 (en) 2020-03-12 2023-06-01 Toray Industries, Inc. Medicament for treatment and/or prevention of cancer
EP4119156A4 (en) 2020-03-12 2024-05-08 Toray Industries, Inc. MEDICINE FOR THE TREATMENT AND/OR PREVENTION OF CANCER
US20230146593A1 (en) 2020-03-12 2023-05-11 Amgen Inc. Method for treatment and prophylaxis of crs in patients comprising a combination of bispecific antibodies binding to cds x cancer cell and tnf alpha or il-6 inhibitor
CN115427454A (zh) 2020-03-19 2022-12-02 安进公司 针对粘蛋白17的抗体及其用途
GB202004371D0 (en) 2020-03-26 2020-05-13 Glaxosmithkline Ip Dev Ltd CAR constructs
JP7329288B2 (ja) 2020-03-27 2023-08-18 株式会社PhotoQ3 腫瘍細胞を死滅させるための医薬
WO2021200131A1 (ja) 2020-03-30 2021-10-07 国立研究開発法人国立がん研究センター 抗体薬物複合体
WO2021202473A2 (en) 2020-03-30 2021-10-07 Danisco Us Inc Engineered antibodies
CN115362171A (zh) 2020-03-31 2022-11-18 百奥泰生物制药股份有限公司 用于治疗冠状病毒的抗体、融合蛋白及其应用
KR20240085798A (ko) 2020-04-03 2024-06-17 비스테라, 인크. 항체 분자-약물 접합체 및 이의 용도
JPWO2021206078A1 (ja) 2020-04-06 2021-10-14
WO2021207449A1 (en) 2020-04-09 2021-10-14 Merck Sharp & Dohme Corp. Affinity matured anti-lap antibodies and uses thereof
AU2021256652A1 (en) 2020-04-14 2022-11-03 Glaxosmithkline Intellectual Property Development Limited Combination treatment for cancer involving anti-ICOS and anti-PD1 antibodies, optionally further involving anti-tim3 antibodies
JP2023521465A (ja) 2020-04-14 2023-05-24 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド ＩＣＯＳ抗体とＰＤ－Ｌ１抗体ＴＧＦ－β－受容体融合タンパク質とに基づく癌の併用治療
JP2023521227A (ja) 2020-04-14 2023-05-23 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド 癌の併用療法
JP2023106635A (ja) 2020-04-17 2023-08-02 中外製薬株式会社 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法
GB202005779D0 (en) 2020-04-21 2020-06-03 Scancell Ltd Anti-tumour immune responses
CA3180321A1 (en) 2020-04-24 2021-10-28 Marengo Therapeutics, Inc. Multifunctional molecules that bind to t cell related cancer cells and uses thereof
MX2022013402A (es) 2020-04-24 2022-11-14 Sanofi Sa Combinaciones antitumorales que contienen productos conjugados de anticuerpos anti-ceacam5 y folfiri.
KR20230005203A (ko) 2020-04-24 2023-01-09 사노피 항-ceacam5 항체 접합체 및 folfox를 함유하는 항종양 조합
TW202206110A (zh) 2020-04-24 2022-02-16 法商賽諾菲公司 包含抗ｃｅａｃａｍ５抗體接合物、三氟胸苷和替吡嘧啶的抗腫瘤組合
TW202203981A (zh) 2020-04-24 2022-02-01 法商賽諾菲公司 含有抗ｃｅａｃａｍ５抗體接合物及西妥昔單抗（ｃｅｔｕｘｉｍａｂ）的抗腫瘤組合
CN113637082A (zh) 2020-04-27 2021-11-12 启愈生物技术(上海)有限公司 一种靶向人claudin和人PDL1蛋白的双特异抗体及其应用
CN115551553A (zh) 2020-05-12 2022-12-30 Inserm(法国国家健康医学研究院) 治疗皮肤t细胞淋巴瘤和tfh起源淋巴瘤的新方法
AU2021275049A1 (en) 2020-05-19 2022-12-22 Amgen Inc. MAGEB2 binding constructs
CN115667515A (zh) 2020-05-22 2023-01-31 中外制药株式会社 中和具有凝血因子viii(f.viii)功能替代活性的物质的抗体
EP3915641A1 (en) 2020-05-27 2021-12-01 International-Drug-Development-Biotech Anti-cd5 antibodies and methods of use thereof
WO2021243320A2 (en) 2020-05-29 2021-12-02 Amgen Inc. Adverse effects-mitigating administration of a bispecific antibody construct binding to cd33 and cd3
BR112022025026A2 (pt) 2020-06-08 2023-02-14 Janssen Biotech Inc Ensaio baseado em células para determinar atividade de morte tumoral in vitro de células imunitárias que expressam antigénio quimérico
EP4165169A1 (en) 2020-06-11 2023-04-19 Novartis AG Zbtb32 inhibitors and uses thereof
KR20230025005A (ko) 2020-06-17 2023-02-21 얀센 바이오테크 인코포레이티드 만능 줄기세포의 제조를 위한 재료 및 방법
EP4174071A4 (en) 2020-06-24 2024-09-11 Univ Tokyo PHOTOSENSITIZING DYE
KR20230042273A (ko) 2020-06-24 2023-03-28 비스테라, 인크. April에 대한 항체 분자 및 그의 용도
WO2022006219A2 (en) 2020-07-02 2022-01-06 Trustees Of Tufts College Vhh polypeptides that bind to clostridium difficile toxin b and methods of use thereof
US20230272386A1 (en) 2020-07-17 2023-08-31 Mitsubishi Tanabe Pharma Corporation Agent for preventing or treating muscular disease
WO2022026592A2 (en) 2020-07-28 2022-02-03 Celltas Bio, Inc. Antibody molecules to coronavirus and uses thereof
KR20230047397A (ko) 2020-07-28 2023-04-07 추가이 세이야쿠 가부시키가이샤 신규 개변형 항체를 포함하는, 바늘 실드를 구비한 바늘 부가 프리필드 시린지 제제
MX2023001120A (es) 2020-07-31 2023-02-22 Chugai Pharmaceutical Co Ltd Composicion farmaceutica que comprende una celula que expresa un receptor quimerico.
CA3187866A1 (en) 2020-08-06 2022-02-10 Jaime Morales ARIAS Inflammatory cytokines and fatigue in subject with a complement mediated disease
WO2022028608A1 (zh) 2020-08-07 2022-02-10 百奥泰生物制药股份有限公司 抗pd-l1抗体及其应用
CN116249718A (zh) 2020-08-26 2023-06-09 马伦戈治疗公司 结合至钙网蛋白的多功能性分子及其用途
EP4204458A1 (en) 2020-08-26 2023-07-05 Marengo Therapeutics, Inc. Methods of detecting trbc1 or trbc2
KR20230074144A (ko) 2020-08-26 2023-05-26 마렝고 테라퓨틱스, 인크. NKp30에 결합하는 항체 분자 및 이의 용도
WO2022043557A1 (en) 2020-08-31 2022-03-03 Advanced Accelerator Applications International Sa Method of treating psma-expressing cancers
EP4204020A1 (en) 2020-08-31 2023-07-05 Advanced Accelerator Applications International S.A. Method of treating psma-expressing cancers
WO2022048883A1 (en) 2020-09-04 2022-03-10 Merck Patent Gmbh Anti-ceacam5 antibodies and conjugates and uses thereof
AU2021357841A1 (en) 2020-10-08 2023-06-15 Affimed Gmbh Trispecific binders
EP3981789A1 (en) 2020-10-12 2022-04-13 Commissariat À L'Énergie Atomique Et Aux Énergies Alternatives Anti-lilrb antibodies and uses thereof
WO2022079297A1 (en) 2020-10-16 2022-04-21 Ac Immune Sa Antibodies binding to alpha-synuclein for therapy and diagnosis
US20240084014A1 (en) 2020-10-16 2024-03-14 Qlsf Biotherapeutics, Inc. Multispecific binding compounds that bind to pd-l1
WO2022087274A1 (en) 2020-10-21 2022-04-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibodies that neutralize type-i interferon (ifn) activity
JP2023551113A (ja) 2020-11-06 2023-12-07 バイオ－テラ ソリュ－ションズ，エルティーディー． 二重特異性抗体及びその応用
MX2023005234A (es) 2020-11-06 2023-05-18 Novartis Ag Terapia de combinacion de agente anti-cd19 y agente de direccionamiento a celulas b para el tratamiento de neoplasias malignas de celulas b.
UY39508A (es) 2020-11-06 2022-05-31 Amgen Res Munich Gmbh Moléculas de unión a antígeno biespecíficas con múltiples dianas de selectividad aumentada
CA3199095A1 (en) 2020-11-06 2022-05-12 Novartis Ag Cd19 binding molecules and uses thereof
KR20230098334A (ko) 2020-11-06 2023-07-03 암젠 리서치 (뮌헨) 게엠베하 Cldn6 및 cd3에 선택적으로 결합하는 폴리펩디드 작제물
TW202225188A (zh) 2020-11-06 2022-07-01 德商安美基研究（慕尼黑）公司 與ｃｄ３結合的多肽構建體
IL301926A (en) 2020-11-06 2023-06-01 Amgen Inc Antigen binding domain with reduced cleavage rate
JP2023549504A (ja) 2020-11-13 2023-11-27 ノバルティス アーゲー キメラ抗原受容体（ｃａｒ）発現細胞との組合せ療法
GB202018395D0 (en) 2020-11-23 2021-01-06 Scancell Ltd Immunotherapy
MX2023006426A (es) 2020-12-01 2023-07-17 Aptevo Res & Development Llc Antígenos asociados a tumores y proteínas de unión a cd3 y composiciones y métodos relacionados.
TWI821804B (zh) 2020-12-02 2023-11-11 英商葛蘭素史密斯克藍智慧財產發展有限公司 Il-7結合蛋白及其於醫療中之用途
WO2022120224A1 (en) 2020-12-04 2022-06-09 Visterra, Inc. Methods of using interleukin-2 agents
TW202237638A (zh) 2020-12-09 2022-10-01 日商武田藥品工業股份有限公司 烏苷酸環化酶ｃ（ｇｃｃ）抗原結合劑之組成物及其使用方法
TW202237639A (zh) 2020-12-09 2022-10-01 日商武田藥品工業股份有限公司 鳥苷酸環化酶ｃ（ｇｃｃ）抗原結合劑之組成物及其使用方法
EP4260872A1 (en) 2020-12-09 2023-10-18 National University Corporation Tokyo Medical and Dental University Agent for preventing or treating frontotemporal lobar degeneration
CN116917491A (zh) 2020-12-18 2023-10-20 Ac免疫有限公司 抗体递送
US20240092892A1 (en) 2020-12-30 2024-03-21 Bio-Thera Solutions, Ltd. Anti-cldn18.2 antibody, and preparation method therefor and use thereof
WO2022148736A1 (en) 2021-01-05 2022-07-14 Transgene Vectorization of muc1 t cell engager
CN117425500A (zh) 2021-01-13 2024-01-19 纪念斯隆凯特琳癌症中心 抗dll3抗体-药物缀合物
KR20230146521A (ko) 2021-01-13 2023-10-19 메모리얼 슬로안 케터링 캔서 센터 항체-피롤로벤조디아제핀 유도체 접합체
JP2024503506A (ja) 2021-01-20 2024-01-25 ビステラ， インコーポレイテッド インターロイキン－２変異体およびその使用
AR124681A1 (es) 2021-01-20 2023-04-26 Abbvie Inc Conjugados anticuerpo-fármaco anti-egfr
EP4281187A1 (en) 2021-01-20 2023-11-29 Bioentre LLC Ctla4-binding proteins and methods of treating cancer
CA3208998A1 (en) 2021-01-22 2022-07-28 Steven Kerrigan Treatment of coronavirus
JP2024506694A (ja) 2021-02-16 2024-02-14 ヤンセン バイオテツク，インコーポレーテツド 増強されたリンカー標的化のための材料及び方法
CN117425674A (zh) 2021-03-02 2024-01-19 丹娜法伯癌症研究院 治疗红细胞疾患的方法
US20240141026A1 (en) 2021-03-04 2024-05-02 Centre National De La Recherche Scientifique Use of a periostin antibody for treating inflammation, fibrosis and lung diseases
WO2022187591A1 (en) 2021-03-05 2022-09-09 Go Therapeutics, Inc. Anti-glyco-cd44 antibodies and their uses
EP4305064A1 (en) 2021-03-12 2024-01-17 Fibrosys S.r.l. Monoclonal antibodies for the treatment of viral infections
KR20230156368A (ko) 2021-03-12 2023-11-14 추가이 세이야쿠 가부시키가이샤 중증 근무력증의 치료 또는 예방용의 의약 조성물
EP4308603A1 (en) 2021-03-17 2024-01-24 Receptos Llc Methods of treating atopic dermatitis with anti il-13 antibodies
JP2024511373A (ja) 2021-03-18 2024-03-13 ノバルティス アーゲー がんのためのバイオマーカーおよびその使用
KR20230160307A (ko) 2021-03-19 2023-11-23 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 클라우딘-3을 표적화하는 키메라 항원 수용체 및 암을 치료하는 방법
WO2022212645A1 (en) 2021-03-31 2022-10-06 Bioverativ Usa Inc. Reducing surgery-associated hemolysis in cold agglutinin disease patients
EP4314068A1 (en) 2021-04-02 2024-02-07 The Regents Of The University Of California Antibodies against cleaved cdcp1 and uses thereof
MX2023011690A (es) 2021-04-02 2023-12-15 Amgen Inc Construcciones de unión a mageb2.
TW202304979A (zh) 2021-04-07 2023-02-01 瑞士商諾華公司 抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途
BR112023020832A2 (pt) 2021-04-08 2023-12-19 Marengo Therapeutics Inc Moléculas multifuncionais ligadas a tcr e seus usos
CA3214934A1 (en) 2021-04-12 2022-10-20 Madhavan Nallani Polymersomes comprising a soluble encapsulated polynucleotide and an ionizable lipid as well as methods of making and uses thereof
BR112023022878A2 (pt) 2021-05-04 2024-01-23 Regeneron Pharma Agonistas do receptor fgf21 multiespecíficos e seus usos
US20240262917A1 (en) 2021-05-06 2024-08-08 Dana-Farber Cancer Institute, Inc. Antibodies against alk and methods of use thereof
EP4334358A1 (en) 2021-05-06 2024-03-13 Amgen Research (Munich) GmbH Cd20 and cd22 targeting antigen-binding molecules for use in proliferative diseases
WO2022261183A2 (en) 2021-06-08 2022-12-15 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating and/or identifying an agent for treating intestinal cancers
CA3218481A1 (en) 2021-06-14 2022-12-22 argenx BV Anti-il-9 antibodies and methods of use thereof
WO2022269473A1 (en) 2021-06-23 2022-12-29 Janssen Biotech, Inc. Materials and methods for hinge regions in functional exogenous receptors
JPWO2022270524A1 (ja) 2021-06-23 2022-12-29
BR112023026985A2 (pt) 2021-06-23 2024-03-12 Toray Industries Medicamento para o tratamento e/ou prevenção do câncer, agente que aumenta a eficácia do medicamento em uma composição farmacêutica, agente para aumentar a eficácia do medicamento em uma composição farmacêutica e método para tratar e/ou prevenir o câncer
KR20240025597A (ko) 2021-06-29 2024-02-27 씨젠 인크. 비푸코실화 항-cd70 항체 및 cd47 길항제의 조합으로 암을 치료하는 방법
EP4378477A1 (en) 2021-07-27 2024-06-05 Toray Industries, Inc. Medicament for treatment and/or prevention of cancer
WO2023010060A2 (en) 2021-07-27 2023-02-02 Novab, Inc. Engineered vlrb antibodies with immune effector functions
MX2024000965A (es) 2021-07-27 2024-02-09 Toray Industries Medicamento para el tratamiento y/o prevencion de cancer.
EP4378476A1 (en) 2021-07-27 2024-06-05 Toray Industries, Inc. Medicament for treatment and/or prevention of cancer
CA3226537A1 (en) 2021-07-29 2023-02-02 Ana HENNINO Humanized anti-human .beta.ig-h3 protein and uses thereof
AU2022318416A1 (en) 2021-07-29 2024-01-25 Takeda Pharmaceutical Company Limited Engineered immune cell that specifically targets mesothelin and uses thereof
IL308154A (en) 2021-07-30 2023-12-01 Affimed Gmbh Double structure antibodies
AU2022324456A1 (en) 2021-08-05 2024-02-15 Go Therapeutics, Inc. Anti-glyco-muc4 antibodies and their uses
CA3228576A1 (en) 2021-08-10 2023-02-16 Byomass Inc. Anti-gdf15 antibodies, compositions and uses thereof
WO2023019200A1 (en) 2021-08-11 2023-02-16 Viela Bio, Inc. Inebilizumab and methods of using the same in the treatment or prevention of igg4-related disease
AU2022334794A1 (en) 2021-08-25 2024-03-28 Iontas Limited Preparation of libraries of protein variants expressed in eukaryotic cells
WO2023025927A1 (en) 2021-08-26 2023-03-02 Glycanostics S.R.O Glycoprotein biomarkers for diagnosing cancer
KR20240101546A (ko) 2021-09-03 2024-07-02 고 테라퓨틱스, 인크. 항-글리코-lamp1 항체 및 그의 용도
CN118354789A (zh) 2021-09-03 2024-07-16 Go医疗股份有限公司 抗糖-cMET抗体及其用途
WO2023033129A1 (ja) 2021-09-03 2023-03-09 東レ株式会社 癌の治療及び／又は予防用医薬組成物
IL310815A (en) 2021-09-14 2024-04-01 Glycanostics S R O Glycoprotein biomarkers for breast cancer diagnosis
WO2023041985A2 (en) 2021-09-15 2023-03-23 New York University In Abu Dhabicorporation Compositions that block activation of the sars-cov-2 replication and transcription complex (rtc) and methods of use thereof
WO2023044483A2 (en) 2021-09-20 2023-03-23 Voyager Therapeutics, Inc. Compositions and methods for the treatment of her2 positive cancer
EP4406556A1 (en) 2021-09-24 2024-07-31 PhotoQ3 Inc. Medicine for killing tumor cells
CN115894689A (zh) 2021-09-30 2023-04-04 百奥泰生物制药股份有限公司 抗b7-h3抗体及其应用
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same
WO2023057871A1 (en) 2021-10-04 2023-04-13 Novartis Ag Surfactant stabilizers
WO2023058705A1 (ja) 2021-10-08 2023-04-13 中外製薬株式会社 抗ｈｌａ－ｄｑ２．５抗体の製剤
CA3235627A1 (en) 2021-10-18 2023-04-27 Byomass Inc. Anti-activin a antibodies, compositions and uses thereof
KR20240099407A (ko) 2021-11-03 2024-06-28 아피메트 게엠베하 이중특이적 cd16a 결합제
MX2024005106A (es) 2021-11-03 2024-07-02 Affimed Gmbh Ligandos biespecificos de cd16a.
EP4177266A1 (en) 2021-11-05 2023-05-10 Katholieke Universiteit Leuven Neutralizing anti-sars-cov-2 human antibodies
WO2023079057A1 (en) 2021-11-05 2023-05-11 Sanofi Antitumor combinations containing anti-ceacam5 antibody-drug conjugates and anti-vegfr-2 antibodies
WO2023079058A1 (en) 2021-11-05 2023-05-11 Yokogawa Insilico Biotechnology Gmbh Cell culture with reduced production of lactate
EP4429765A1 (en) 2021-11-10 2024-09-18 Astrazeneca AB Antibody molecules and conjugates
WO2023092004A1 (en) 2021-11-17 2023-05-25 Voyager Therapeutics, Inc. Compositions and methods for the treatment of tau-related disorders
AU2022396272A1 (en) 2021-11-24 2024-06-06 Dana-Farber Cancer Institute, Inc. Antibodies against ctla-4 and methods of use thereof
WO2023097254A1 (en) 2021-11-24 2023-06-01 Visterra, Inc. Engineered antibody molecules to cd138 and uses thereof
WO2023097119A2 (en) 2021-11-29 2023-06-01 Dana-Farber Cancer Institute, Inc. Methods and compositions to modulate riok2
CA3239389A1 (en) 2021-12-01 2023-06-08 Kohei SOEDA Method for preparing antibody-containing formulation
TW202333772A (zh) 2021-12-01 2023-09-01 美商威特拉公司 使用介白素-2藥劑之方法
GB202117928D0 (en) 2021-12-11 2022-01-26 Cancer Research Tech Ltd Immunotherapy for cancer
CA3241407A1 (en) 2021-12-17 2023-06-22 Dana-Farber Cancer Institute, Inc. Platform for antibody discovery
CA3241395A1 (en) 2021-12-17 2023-06-22 Barbel SCHROFELBAUER Antibodies and uses thereof
WO2023122213A1 (en) 2021-12-22 2023-06-29 Byomass Inc. Targeting gdf15-gfral pathway cross-reference to related applications
CN116333135A (zh) 2021-12-24 2023-06-27 百奥泰生物制药股份有限公司 抗FRα抗体及其抗体药物偶联物和用途
AR128222A1 (es) 2022-01-07 2024-04-10 Johnson & Johnson Entpr Innovation Inc MATERIALES Y MÉTODOS DE PROTEÍNAS DE UNIÓN A IL-1b
WO2023147107A1 (en) 2022-01-31 2023-08-03 Byomass Inc. Myeloproliferative conditions
WO2023148598A1 (en) 2022-02-02 2023-08-10 Pfizer Inc. Cysteine prototrophy
WO2023150778A1 (en) 2022-02-07 2023-08-10 Visterra, Inc. Anti-idiotype antibody molecules and uses thereof
WO2023172968A1 (en) 2022-03-09 2023-09-14 Merck Patent Gmbh Anti-gd2 antibodies, immunoconjugates and therapeutic uses thereof
TW202346354A (zh) 2022-03-09 2023-12-01 德商馬克專利公司 抗ceacam5抗體及其結合物及用途
WO2023170434A1 (en) 2022-03-11 2023-09-14 Macomics Limited Compositions and methods for modulation of macrophage activity
EP4245772A1 (en) 2022-03-18 2023-09-20 Netris Pharma Anti-netrin-1 antibody to treat liver inflammation
EP4249509A1 (en) 2022-03-22 2023-09-27 Netris Pharma Anti-netrin-1 antibody against arthritis-associated pain
WO2023186968A1 (en) 2022-03-29 2023-10-05 Netris Pharma Novel mcl-1 inhibitor and combination of mcl-1 and a bh3 mimetic, such as a bcl-2 inhibitor
US20240092921A1 (en) 2022-04-25 2024-03-21 Visterra, Inc. Antibody molecules to april and uses thereof
WO2023215498A2 (en) 2022-05-05 2023-11-09 Modernatx, Inc. Compositions and methods for cd28 antagonism
WO2023218027A1 (en) 2022-05-12 2023-11-16 Amgen Research (Munich) Gmbh Multichain multitargeting bispecific antigen-binding molecules of increased selectivity
WO2023220695A2 (en) 2022-05-13 2023-11-16 Voyager Therapeutics, Inc. Compositions and methods for the treatment of her2 positive cancer
AR129445A1 (es) 2022-05-27 2024-08-28 Glaxosmithkline Ip Dev Ltd USO DE PROTEÍNAS DE UNIÓN A TNF-a Y PROTEÍNAS DE UNIÓN A IL-7 EN EL TRATAMIENTO MÉDICO
WO2023239803A1 (en) 2022-06-08 2023-12-14 Angiex, Inc. Anti-tm4sf1 antibody-drug conjugates comprising cleavable linkers and methods of using same
WO2023240287A1 (en) 2022-06-10 2023-12-14 Bioentre Llc Combinations of ctla4 binding proteins and methods of treating cancer
WO2023245048A1 (en) 2022-06-15 2023-12-21 Bioverativ Usa Inc. Anti-complement c1s antibody formulation
EP4296279A1 (en) 2022-06-23 2023-12-27 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Anti-transthyretin (ttr) binding proteins and uses thereof
US20240025978A1 (en) 2022-06-24 2024-01-25 Bioverativ Usa Inc. Methods for treating complement-mediated diseases
WO2024002938A1 (en) 2022-06-27 2024-01-04 Astrazeneca Ab Combinations involving epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer
WO2024015953A1 (en) 2022-07-15 2024-01-18 Danisco Us Inc. Methods for producing monoclonal antibodies
WO2024013727A1 (en) 2022-07-15 2024-01-18 Janssen Biotech, Inc. Material and methods for improved bioengineered pairing of antigen-binding variable regions
WO2024018426A1 (en) 2022-07-22 2024-01-25 Janssen Biotech, Inc. Enhanced transfer of genetic instructions to effector immune cells
WO2024030982A2 (en) 2022-08-02 2024-02-08 Diadem Spa Device for detection and prognostic assessment of neurodegenerative disorders
WO2024030976A2 (en) 2022-08-03 2024-02-08 Voyager Therapeutics, Inc. Compositions and methods for crossing the blood brain barrier
WO2024039672A2 (en) 2022-08-15 2024-02-22 Dana-Farber Cancer Institute, Inc. Antibodies against msln and methods of use thereof
WO2024039670A1 (en) 2022-08-15 2024-02-22 Dana-Farber Cancer Institute, Inc. Antibodies against cldn4 and methods of use thereof
WO2024042105A1 (en) 2022-08-26 2024-02-29 Merck Patent Gmbh Cancer treatment comprising an anti-msln/cd137 antibody and a chemotherapeutic
WO2024042104A1 (en) 2022-08-26 2024-02-29 Merck Patent Gmbh Combination cancer treatment comprising an anti-msln/cd137 antibody and pd-1/pd-l1 inhibitor
WO2024050524A1 (en) 2022-09-01 2024-03-07 University Of Georgia Research Foundation, Inc. Compositions and methods for directing apolipoprotein l1 to induce mammalian cell death
WO2024050526A1 (en) 2022-09-02 2024-03-07 Biomarin Pharmaceutical Inc. Compositions and methods for treating long qt syndrome
WO2024056668A1 (en) 2022-09-12 2024-03-21 Institut National de la Santé et de la Recherche Médicale New anti-itgb8 antibodies and its uses thereof
TW202421650A (zh) 2022-09-14 2024-06-01 美商安進公司 雙特異性分子穩定組成物
WO2024056862A1 (en) 2022-09-15 2024-03-21 Avidicure Ip B.V. Multispecific antigen binding proteins for tumor-targeting of nk cells and use thereof
US12054552B2 (en) 2022-09-21 2024-08-06 Sanofi Biotechnology Humanized anti-IL-1R3 antibody and methods of use
WO2024068996A1 (en) 2022-09-30 2024-04-04 Centre Hospitalier Universitaire Vaudois (C.H.U.V.) Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection
WO2024097639A1 (en) 2022-10-31 2024-05-10 Modernatx, Inc. Hsa-binding antibodies and binding proteins and uses thereof
WO2024097441A1 (en) 2022-11-02 2024-05-10 Kira Pharmaceuticals (Us) Llc Anti-c5 antibody fused to factor h for use in the treatment of complement-mediated diseases
WO2024097796A1 (en) 2022-11-02 2024-05-10 Kira Pharmaceuticals (Us) Llc Anti-c5 antibody fused to factor h for use in the treatment of complement-mediated diseases
WO2024118866A1 (en) 2022-12-01 2024-06-06 Modernatx, Inc. Gpc3-specific antibodies, binding domains, and related proteins and uses thereof
WO2024133052A1 (en) 2022-12-19 2024-06-27 Universität Basel Vizerektorat Forschung T-cell receptor fusion protein
WO2024133858A1 (en) 2022-12-22 2024-06-27 Julius-Maximilians-Universität-Würzburg Antibodies for use as coagulants
WO2024152014A1 (en) 2023-01-13 2024-07-18 Regeneron Pharmaceuticals, Inc. Fgfr3 binding molecules and methods of use thereof
WO2024167898A1 (en) 2023-02-07 2024-08-15 Go Therapeutics, Inc. ANTIBODY FUSION PROTEINS COMPRISING ANTI-GLYCO-MUC4 ANTIBODIES AND MIC PROTEIN α1-α2 DOMAINS, AND THEIR USES
WO2024168061A2 (en) 2023-02-07 2024-08-15 Ayan Therapeutics Inc. Antibody molecules binding to sars-cov-2
WO2024178305A1 (en) 2023-02-24 2024-08-29 Modernatx, Inc. Compositions of mrna-encoded il-15 fusion proteins and methods of use thereof for treating cancer
WO2024180085A1 (en) 2023-02-27 2024-09-06 Netris Pharma Anti-netrin-1 monoclonal antibody for treating endometriosis and associated pains
WO2024180192A1 (en) 2023-03-01 2024-09-06 Sanofi Use of anti-ceacam5 immunoconjugates for treating neuroendocrine cancers expressing ceacam5
EP4427763A1 (en) 2023-03-06 2024-09-11 Sanofi Antitumor combinations containing anti-ceacam5 antibody-drug conjugates, anti-vegfr-2 antibodies and anti-pd1/pd-l1 antibodies
WO2024187062A1 (en) 2023-03-08 2024-09-12 Amgen Inc. Controlled-ice nucleation lyophilization process for bispecific molecules
EP4431526A1 (en) 2023-03-16 2024-09-18 Emfret Analytics GmbH & Co. KG Anti-gpvi antibodies and functional fragments thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
EP0173494A3 (en) * 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) * 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61104788A (ja) * 1984-10-26 1986-05-23 Teijin Ltd 核酸塩基配列
JPS61134325A (ja) * 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Ｐｒｏｃ．Ｎａｔｌ．Ａｃａｄ．Ｓｃｉ．ＵＳＡ，Ｖｏｌ．８２（１９８５）Ｐ．２１２５−２１２７

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005068504A1 (ja) 2004-01-19 2005-07-28 Medical And Biological Laboratories Co., Ltd. 炎症性サイトカイン抑制剤
WO2009057664A1 (ja) 2007-10-29 2009-05-07 Mitsubishi Chemical Corporation 抗体及びその利用
US8445649B2 (en) 2007-10-29 2013-05-21 Tao Health Life Pharma Co., Ltd. Antibody and use thereof
WO2012005076A1 (ja) 2010-07-08 2012-01-12 本田技研工業株式会社 高周波加熱用コイル
WO2012023622A1 (ja) 2010-08-16 2012-02-23 国立大学法人九州大学 腫瘍の検査用試薬及び腫瘍の予防用医薬組成物
WO2014021339A1 (ja) 2012-07-30 2014-02-06 国立大学法人名古屋大学 ヒトミッドカインに対するモノクローナル抗体
WO2014042251A1 (ja) 2012-09-13 2014-03-20 中外製薬株式会社 遺伝子ノックイン非ヒト動物
EP3584260A1 (en) 2015-04-28 2019-12-25 Mitsubishi Tanabe Pharma Corporation Rgma binding protein and use thereof
WO2020013238A1 (ja) 2018-07-10 2020-01-16 田辺三菱製薬株式会社 末梢神経障害又は末梢神経障害若しくはアストロサイト障害が認められる疾患に伴う疼痛の予防又は治療方法
WO2021132673A1 (ja) 2019-12-26 2021-07-01 国立大学法人大阪大学 急性期の視神経脊髄炎の予防又は治療剤
WO2021145432A1 (ja) 2020-01-15 2021-07-22 国立大学法人大阪大学 糖尿病性自律神経障害の予防又は治療剤
WO2021145435A1 (ja) 2020-01-15 2021-07-22 国立大学法人大阪大学 認知症の予防又は治療剤
WO2022176970A1 (ja) 2021-02-18 2022-08-25 田辺三菱製薬株式会社 新規抗ｐａｄ４抗体

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ATE109508T1 (de) 1994-08-15
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DE3750304D1 (de) 1994-09-08
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DE3750304T2 (de) 1994-12-22
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