JPH08500487A - L鎖欠落免疫グロブリン - Google Patents
L鎖欠落免疫グロブリンInfo
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- JPH08500487A JPH08500487A JP6505903A JP50590394A JPH08500487A JP H08500487 A JPH08500487 A JP H08500487A JP 6505903 A JP6505903 A JP 6505903A JP 50590394 A JP50590394 A JP 50590394A JP H08500487 A JPH08500487 A JP H08500487A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/20—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.1箇所の完全抗原結合部位又は数箇所の抗原結合部位の形成に十分な2本 のHポリペプチド鎖を含み、かつ、Lポリペプチド鎖を欠落していることを特徴 とする免疫グロブリン。 2.1箇所の完全抗原結合部位又は数箇所の抗原結合部位の形成に十分な2本 のHポリペプチド鎖を含み、かつ、Lポリペプチド鎖を欠落していることを特徴 とし、更にラクダのリンパ球又はその他の細胞から得られるL鎖欠落免疫グロブ リンの配列を有するDNA若しくはcDNAの、原核又は真核宿主細胞における 発現の生成物であることを特徴とする請求の範囲第1載の免疫グロブリン。 3.可変部のアミノ酸配列が45位に、ロイシン又はプロリン若しくはグルタ ミン残基とは異なるアミノ酸を含有することを特徴とする、請求の範囲第1項又 は第2項記載の免疫グロブリン。 4.Hポリペプチド鎖がその定常部(CH1)においていわゆる第1ドメイン を欠落していることを特徴とする、請求の範囲第1項から第3項のいずれか1項 記載の免疫グロブリン。 5.1箇所の抗原結合部位又は数箇所の抗原結合部位を含み、特に各H鎖の各 可変部が、少なくとも1箇所の抗原結合部位を含有することを特徴とする、請求 の範囲第1項から第4項のいずれか1項記載の免疫グロブリン。 6.クラス2のG型免疫ダロブリン(IgG2)又はクラス3のG型免疫グロブリ ン(IgG3)であることを特徴とする、請求の範囲第1項から第5項のいずれか1項 記載の免疫グロブリン。 7.ラクダ免疫ダロブリンであることを特徴とする、請求の範囲第1項から第 6項のいずれか1項記載の免疫グロブリン。 8.ラクダの血清から精製により得ることができ、 −クロマトグラフィーによりプロテインGセファロースカラムに吸着されず、 −クロマトグラフィーによりプロテインAセファロースカラムに吸着され、 −pH4.5の緩衝液(NaC1 0.15M、酢酸0.58%、NaOHにより pH4.5に調整)による溶離後、約100Kdの分子量を有し、 −還元後の分子量約45Kd、好ましくは46KdのHγ2ポリペプチド鎖からなる ことを特徴とする、請求の範囲第1項から第7項のいずれか1項記載の免疫グロ ブリン。 9.ラクダの血清から精製により得ることができ、 −クロマトグラフィーによりプロテインAセファロースカラムに吸着され、 −pH3.5の緩衝液(NaC1 0.15M、酢酸0.58%)による溶離後、 約100Kdの分子量を有し、 −クロマトグラフィーによりプロテインGセファロースカラムに吸着され、pH3 .5の緩衝液(NaC1 0.15M、酢酸0.58%)により溶離され、 −還元後、約45Kd、特に43〜47Kdの間の分子量のHγ3ポリペプチド鎖か らなることを特徴とする、請求項第1項から第7項のいずれか1項記載の免疫グ ロブリン。 10.−その可変部において、以下の配列: 枠組み構造(フレームワーク)1のドメインに関し、 枠組み構造4のドメインに関し、 及び/又は、 CDR3ドメインに関し、 から選択されるアミノ酸配列を含む、4個の枠組み構造を含み、 及び/又は、 −その定常部が、以下の配列:CH2ドメインに関し、 CH3ドメインに関し、 から選択されるアミノ酸配列を含むCH2及びCH 3ドメインを含み、 及び/又は、 −そのヒンジ部が0から50個のアミノ酸からなり、特にそのヒンジ部が、以下 の配列: 又は から選択されるアミノ酸配列を含む ことを特徴とする、請求の範囲第1項から第9項のいずれか1項記載の免疫グロ ブリン。 11.図7に示されるものから選択される配列によってコード化されることを特 徴とする、請求の範囲第1項から第10項のいずれか1項記載の免疫グロブリン 。 12.以下の群: −L鎖欠落免疫グロブリンの1本のHポリペプチド鎖に対応する断片、 −本発明の免疫グロブリンの酵素消化により得られる断片、特にパパインによる 部分消化により得られる、Fc断片(定常断片)及びFVHHh断片(H鎖の抗原 結合部位を含有する)もしくはその二量体F(VHHh)2に至る断片、又はFc 断片をパパインにより更に消化することによって得られる、Fc断片のC末端部 に相当するFc′断片に至る断片、 −その他のタンパク質分解酵素により得られる相同断片、 −免疫グロブリンの可変部の少なくとも10個、好ましくは20個のアミノ酸の 断片若しくは完全可変部、特に分離されたVHHドメイン又はヒンジジスルフィド に結合したVHH二量体に対応する断片、 −免疫ダロブリンのヒンジ部又はこのヒンジ部の少なくとも6個のアミノ酸に対 応する断片、 −Pro−Xの反復配列を含むヒンジ部の断片、 −免疫グロブリンの、定常部の少なくとも10個、好ましくは20個のアミノ酸 又は完全定常部に対応する断片、 から選択されることを特徴とする、請求の範囲第1項から第11項のいずれか1 項記載の免疫グロブリンの断片。 13.その定常部の全部又は一部が、ヒト抗体の定常部の全部又は一部により置 換されていることを特徴とする、請求の範囲第1項から第12項のいずれか1項 記載の免疫グロブリン。 14.原核細胞、特にE.coli 細胞において、以下の工程、すなわち、 a)例えばラクダのリンパ球から得ることができるL鎖欠落免疫グロブリンのVH ドメインをコードするDNA又はcDNA配列をブルースクリプト(Bluescrip t)ベクター中でクローン化する工程、 b)Xho部位を含む5′プライマー及び以下の配列: を有するSpe部位を含む3′プライマーを用いて増幅した後、クローン化した 断片を回収する工程、 c)免疫PBSベクターをXho及びSpe制限酵素により消化した後、べクタ ー中、相中で、回収された断片をクローン化する工程、 d)宿主細胞、特にE.coliを、工程cの組換え免疫PBSベクターによるト ランスフェクションにより形質転換する工程、 e)例えば、ヒトコブラクダVHHドメインに対する抗体を用いて、VHHをコード する配列の発現物を回収する工程 を含む方法により得ることができる、請求の範囲第1項から第13項のいずれか 1項記載の免疫グロブリン。 15.以下の工程、すなわち: −与えられた抗原に対する所定の特異性を有し、Xho及びSpe部位の間に含 まれる、VHHドメイン若しくはその一部をコードする第1のDNA又はcDNA 配列を得る工程、 −第1のDNA又はcDNA配列の特異性とは異なる所定の特異性を有し、Sp e及びEcoRI部位の間に含まれる、VHHドメイン若しくはその一部をコー ドする第2のDNA又はcDNA配列を得る工程、 −EoRI及びXhoI制限酵素によりイムノPBSベクターを消化する工程、 −得られた、VHHドメインをコードするDNA又はcDNA配列を、このDNA 又はcDNA配列がべクター中で連続してクローン化されるように連結する工程 、 −宿主細胞、特にE.coli細胞を、トランスフェクションにより形質転換し、得 られる免疫グロブリンを回収する工程 を含む方法によって得ることができる、請求の範囲第1項から第13項のいずれ か1項記載の異種特異的免疫グロブリン。 16.以下の工程、すなわち: −所定の特異的抗原結合部位を有するVHHドメイン若しくはその一部をコードす るDNA又はcDNA配列を得る工程、 −開始コドン及びHindIII部位を含有する5′プライマー並びに終止コド ン及びXhoI部位を有する3′プライマーを用いて、得られたDNA又はcD NAを増幅する工程、 −増幅されたDNA又はcDNAを、プラスミドpMM984の HindIII(2650位)及びXhoI(4067位)部位中に組換える工 程、 −組換えプラスミドにより、許容される細胞、特にNB−E細胞をトランスフェ クションする工程、 −例えば、VHHドメイン部分に対する抗体を用いるELISA法により発現物を 制御し、得られた生成物を回収する工程 を含む方法により得ることができる、請求の範囲第1項から第13項のいずれか 1項記載の免疫グロブリン。 17.別の所定の抗原結合部位を有する第2のDNA又はcDNA配列を、pM M984プラスミド中で更にクローン化することを含む方法により得ることがで きる、請求項16項記載の免疫グロブリン。 18.べクターがYep52であり、形質転換される組換え細胞が酵母、特にS .cerevisiaeである方法により得ることができることを特徴とする、請求の範囲 第11項から第17項のいずれか1項記載の免疫グロブリン。 19.べクターが、植物細胞における発現に適したべクター、例えばpMon5 30であり、形質転換される組換え細胞が植物細胞である方法により得ることが できることを特徴とする、請求の範囲第11項から第17項のいずれか1項記載 の免疫グロブリン。 20.触媒活性を有し、特に与えられた基質の活性化状態を模倣(ミミック)す る抗原に向けられ、これらの免疫グロブリンは、例えば無作為又は指向突然変異 誘発によりその触媒部位のレベルにおいて修飾されていることを特徴とする、請 求の範囲第16項又は第 17項記載の免疫グロブリン。 21.免疫グロブリンが、以下の: 及び/又は より選択されるぺプチド配列を含む、請求の範囲第1項から第20項のいずれか 1項記載の免疫グロブリンの全部又は一部をコードすることを特徴とするヌクレ オチド配列。 22.請求の範囲第1項から第20項のいずれか1項記載の免疫グロブリンをコ ードし、図7に示すものから選択される配列からなることを特徴とするヌクレオ チド配列。 23.所定の抗原に向けられ、抗体の抗原結合部位がHポリペプチド鎖からなり 、抗体が更にLポリペプチド鎖を欠落している、請求の範囲第1項から第20項 のいずれか1項記載のモノクローナル抗体を製造する方法であって、 −例えば、所定の抗原によりあらかじめ免疫化されたラクダの末梢血液から得た リンパ球を、不朽細胞、好ましくは骨髄腫細胞によ り不朽化して、ハイブリドーマを形成し、−形成された不朽細胞を培養し、所定 の特異性を有する抗体を産生する細胞を回収する ことを含む方法。 24.所定の抗原に向けられた抗体を製造する方法であって、以下の工程、すな わち: −請求の範囲第1項から第20項のいずれか一項記載の免疫グロブリンの産生能 を有する、あらかじめ所定の抗原により免疫されたラクダのリンパ球から得たD NA又はcDNA配列を、べクター中、特にファージ、そしてより詳細にはフィ ラメント状バクテリオファージ中でクローン化する工程、 −抗体産生を可能とする条件下で、上記のベクターにより原核細胞を形質転換す る工程、 −形質転換された細胞に抗原親和性選択を受けさせることによって、適当な抗体 を選択する工程、 −所望の特異性を有する抗体を回収する工程 を含む方法。 25.クローニングベクターがプラスミド又は真核ウイルスであり、形質転換さ れる細胞が真核細胞、特に酵母細胞、哺乳類細胞、植物細胞又は原生動物細胞で ある、請求の範囲第24項記載の方法。 26.クローニングベクターが、細菌膜において免疫グロブリンを発現すること ができるプラスミドである、請求の範囲第24項記載の方法。 27.クローニングベクターが分泌タンパク質として免疫グロブリンを発現する ことができるプラスミドである、請求の範囲第24項記載の方法。 28.細菌、ウイルス、寄生物の抗原のような抗原、又はタンパク質、ハプテン 、炭水化物又は核酸に対するものであることを特徴とする、請求の範囲第1項か ら第20項のいずれか1項記載の免疫グロブリン。 29.免疫グロブリンイディオタイプに対するものであることを特徴とする、請 求の範囲第1項から第20項のいずれか1項記載の免疫グロブリン。 30.細胞受容体又は膜タンパク質に対するものであることを特徴とする、請求 項第1項から第20項のいずれか1項記載の免疫グロブリン。 31.触媒活性を有することを特徴とする、請求の範囲第1項から第20項のい ずれか1項記載の免疫グロブリン。 32.毒素と結合していることを特徴とする、請求項第1項から第20項のいず れか1項記載の免疫グロブリン又は請求項第12項記載の断片。 33.Xがアミノ酸、そして好ましくはGln、Lys又はGluであるPro −Xの反復配列であって、有利にはPro−Xの少なくとも3反復を含有する配 列からなる断片、そして特にPro−Xの12反復配列からなる断片の、タンパ ク質ドメイン又はタンパク質とリガンドとをカップリングさせるための用途。 34.タンパク質ドメイン又はタンパク質とリガンドとをカップ リングさせるための、請求の範囲第1項から第20項のいずれか1項記載の免疫 グロブリンのヒンジ部若しくはヒンジ部の断片の用途。 35.異種特異性抗体であることを特徴とする、請求の範囲第1項から第20項 のいずれか1項記載の免疫グロブリン。 36.請求の範囲第21項又は第22項記載のヌクレオチド配列を含み、プラス ミド、ファージ、特にバクテリオファージ、ウイルス、YAC、コスミドである ことを特徴とする、組換えべクター。 37.請求の範囲第36項記載のベクターにより変性されていることを特徴とす る組換え細胞又は生物。 38.以下の工程、すなわち: a)B−リンパ球を分離するために、特にラクダから選択される健康な動物から の、リンパ球、特に末梢リンパ球、脾細胞、リンパ節又は別のリンパ組織を含む 試料を処理する工程、 b)細胞の他の核酸及び成分からポリアデニル化されたRNAを分離する工程、 c)対応するcDNAを得るために、得られたRNAを逆転写酵素と反応させる 工程、 d)マウスの4本鎖免疫グロブリンのVHドメインに対応する5′プライマーで あって、所定の制限部位、例えばXhoI部位を含有するプライマー及び、CH 2ドメインのN末端部に対応する3′プライマーを、得られたcDNAと接触さ せる工程、 e)DNAを増幅する工程、 f)べクター中、特にブルースクリプトベクター(bluescript)中において、増幅 された配列をクローン化する工程、 g)分離されたH鎖免疫グロブリンからの定常ドメインをコードする配列に対応 するプローブとハイブリッド形成するクローンを回収する工程、 を行うことによって得られるような、請求の範囲第1項から第20項のいずれか 1項記載のH鎖免疫グロブリンをコードするヌクレオチド配列からなるcDNA ライブラリー。 39.VH部が、請求の範囲第1項から20項のいずれか1項記載のH鎖免疫グ ロブリンの特定配列若しくはアミノ酸により部分的に置換されている、修飾され た4本鎖免疫グロブリン又はその断片。 40.VH部の45位においてロイシン、プロリン又はグルタミンが、他のアミ ノ酸、そして好ましくはアルギニン、グルタミン酸若しくはシステインにより置 換されている、請求の範囲第39項記載の修飾された4本鎖免疫グロブリン又は その断片。 41.領域(部)のCDRループが、対合システインの導入によりV部の他の部 に連結されている、特にCDR3ループがFW2又はCDR1に連結されている、 そして更に特に、VHのCDR3のシステインがFW2の31位若しくは33位、 又はCDR2の45位においてシステインと連結している、修飾された4本鎖免 疫グロブリン又はその断片。
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EP93401310.3 | 1993-05-21 | ||
EP93401310 | 1993-05-21 | ||
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010518839A (ja) * | 2007-02-21 | 2010-06-03 | アブリンクス エン.ヴェー. | 血管内皮増殖因子に指向性を有するアミノ酸配列、及び過度の及び/もしくは病的な血管形成又は血管新生を特徴とする症状及び疾患を治療するためにこれを含むポリペプチド |
JP2011256169A (ja) * | 2002-11-08 | 2011-12-22 | Ablynx Nv | 治療用ポリペプチドの投与法およびそのためのポリペプチド |
Families Citing this family (1105)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6765087B1 (en) * | 1992-08-21 | 2004-07-20 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
WO1994025591A1 (en) * | 1993-04-29 | 1994-11-10 | Unilever N.V. | PRODUCTION OF ANTIBODIES OR (FUNCTIONALIZED) FRAGMENTS THEREOF DERIVED FROM HEAVY CHAIN IMMUNOGLOBULINS OF $i(CAMELIDAE) |
EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
EP0937140B1 (en) * | 1996-06-27 | 2007-09-26 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Antibody molecules which interact specifically with the active site or cleft of a target molecule |
US20040248201A1 (en) * | 1996-06-27 | 2004-12-09 | Serge Muyldermans | Recognition molecules interacting specifically with the active site or cleft of a target molecule |
DK0931097T3 (da) * | 1996-10-10 | 2006-01-16 | Neose Technologies Inc | Kulhydratoprensning ved anvendelse af omvendt osmose og nanofiltrering |
US20030228310A1 (en) * | 1996-12-23 | 2003-12-11 | Advanced Biotherapy, Inc. | Treatment of skin diseases |
BR9907241A (pt) * | 1998-01-26 | 2000-10-17 | Unilever Nv | Biblioteca de expressão, processo para preparar a mesma, uso de uma fonte não imunizada de sequências de ácido nucleico, e, processos para preparar fragmentos de anticorpos e, para preparar um anticorpo |
JP2002512776A (ja) * | 1998-04-28 | 2002-05-08 | スミスクライン・ビーチャム・コーポレイション | 免疫原性の低下したモノクローナル抗体 |
CN100434441C (zh) | 1999-04-22 | 2008-11-19 | 荷兰联合利华有限公司 | 利用单价抗原-结合蛋白抑制病毒感染 |
US6924359B1 (en) | 1999-07-01 | 2005-08-02 | Yale University | Neovascular-targeted immunoconjugates |
BR0012711A (pt) | 1999-07-27 | 2002-04-09 | Unilever Nv | Composição detergente enzimática, e, processos para aumentar a atividade e / ou a estabilidade de uma oxidorredutase dependente de co-fator e para branquear manchas presentes em tecidos |
JP2003509438A (ja) * | 1999-09-16 | 2003-03-11 | ユニリーバー・ナームローゼ・ベンノートシヤープ | 抗フケ剤の送達システム |
US6479280B1 (en) * | 1999-09-24 | 2002-11-12 | Vlaams Interuniversitair Institutuut Voor Biotechnologie Vzw | Recombinant phages capable of entering host cells via specific interaction with an artificial receptor |
EP1088892A1 (en) * | 1999-09-24 | 2001-04-04 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Recombinant phages capable of entering host cells via specific interaction with an artificial receptor |
WO2001040310A2 (en) | 1999-11-29 | 2001-06-07 | Unilever Plc | Immobilisation of proteins using a polypeptide segment |
EP1118669A3 (en) * | 1999-12-17 | 2001-08-29 | Unilever Plc | Production of camelid antibodies in plants |
ES2324280T3 (es) | 2000-03-14 | 2009-08-04 | Unilever N.V. | Dominios variables de la cadena pesada de anticuerpos frente a lipasas dieteticas humanas y sus usos. |
US6696620B2 (en) * | 2000-05-02 | 2004-02-24 | Epicyte Pharmaceutical, Inc. | Immunoglobulin binding protein arrays in eukaryotic cells |
WO2001090190A2 (en) * | 2000-05-26 | 2001-11-29 | National Research Council Of Canada | Single-domain antigen-binding antibody fragments derived from llama antibodies |
WO2002057445A1 (en) * | 2000-05-26 | 2002-07-25 | National Research Council Of Canada | Single-domain brain-targeting antibody fragments derived from llama antibodies |
US20050196755A1 (en) * | 2000-11-17 | 2005-09-08 | Maurice Zauderer | In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells |
ATE352040T1 (de) * | 2000-11-17 | 2007-02-15 | Univ Rochester | In-vitro verfahren zur herstellung und identifizierung von immunglobulin moleküle in eukaryotischen zellen |
US20060064782A1 (en) * | 2000-12-18 | 2006-03-23 | Conopco, Inc. | Production of antibodies |
DE60139811D1 (de) | 2000-12-19 | 2009-10-15 | Unilever Nv | Stabilisierung von schwerkettigen Kamelantikörpern durch Kaliumsalze |
WO2002051870A2 (en) * | 2000-12-22 | 2002-07-04 | GRAD, Carole Legal Representative of KAPLAN, Howard | Phage display libraries of human vh fragments |
DE60239317D1 (de) | 2001-01-12 | 2011-04-14 | Novartis Vaccines & Diagnostic | Nukleinsäure mukosale immunisierung |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
US7829084B2 (en) * | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
US7754208B2 (en) * | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
US20050069538A1 (en) * | 2003-09-18 | 2005-03-31 | Gregorio Aversa | Therapeutic binding molecules |
US20040058445A1 (en) * | 2001-04-26 | 2004-03-25 | Ledbetter Jeffrey Alan | Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB |
US20040086508A1 (en) * | 2001-06-05 | 2004-05-06 | Advanced Biotherapy, Inc. | Treatment of organ transplant rejection |
US20040062768A1 (en) * | 2001-06-05 | 2004-04-01 | Advanced Biotherapy, Inc. | Compositions and methods for treating hyperimmune response in the eye |
US6861056B2 (en) * | 2001-06-05 | 2005-03-01 | Advanced Biotherapy, Inc. | Compositions and methods for treating hyperimmune response in the eye |
US20050152902A1 (en) * | 2001-06-05 | 2005-07-14 | Advanced Biotherapy, Inc. | Treatment of diabetic retinopathy |
JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
EP1456237A2 (en) * | 2001-12-21 | 2004-09-15 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Method for cloning of variable domain sequences |
WO2003055527A2 (en) * | 2002-01-03 | 2003-07-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Immunoconjugates useful for treatment of tumours |
AU2003205615B2 (en) | 2002-01-10 | 2008-09-25 | Universiteit Gent | A novel splice variant of MyD88 and uses thereof |
EP1516054B1 (de) | 2002-02-10 | 2009-12-02 | Topotarget Switzerland SA | Fusionkonstrukte, enthaltend aktive abschnitte von tnf-liganden |
US20030219436A1 (en) * | 2002-03-15 | 2003-11-27 | Ledbetter Jeffrey A. | Compositions and methods to regulate an immune response using CD83 gene expressed in tumors and using soluble CD83-Ig fusion protein |
US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
JP2006512895A (ja) * | 2002-06-28 | 2006-04-20 | ドマンティス リミテッド | リガンド |
US20040175378A1 (en) | 2002-07-15 | 2004-09-09 | Board Of Regents, The University Of Texas System | Selected antibody compositions and methods for binding to aminophospholipids |
AU2003251238A1 (en) | 2002-08-07 | 2004-02-25 | Umc Utrecht Holding B.V. | Modulation of platelet adhesion based on the surface exposed beta-switch loop of platelet glycoprotein ib-alpha |
US7425620B2 (en) | 2002-08-14 | 2008-09-16 | Scott Koenig | FcγRIIB-specific antibodies and methods of use thereof |
GB0219720D0 (en) * | 2002-08-23 | 2002-10-02 | Univ Aberdeen | Polypeptide |
US20040052790A1 (en) * | 2002-09-18 | 2004-03-18 | Advanced Biotherapy, Inc. | Treatment of schizophrenia |
US20060228355A1 (en) | 2003-11-07 | 2006-10-12 | Toon Laeremans | Camelidae single domain antibodies vhh directed against epidermal growth factor receptor and uses therefor |
US20060034845A1 (en) | 2002-11-08 | 2006-02-16 | Karen Silence | Single domain antibodies directed against tumor necrosis factor alpha and uses therefor |
AU2003286004A1 (en) | 2002-11-08 | 2004-06-07 | Ablynx N.V. | Single domain antibodies directed against interferon- gamma and uses therefor |
US9320792B2 (en) | 2002-11-08 | 2016-04-26 | Ablynx N.V. | Pulmonary administration of immunoglobulin single variable domains and constructs thereof |
GB0230203D0 (en) * | 2002-12-27 | 2003-02-05 | Domantis Ltd | Fc fusion |
AU2004204262B2 (en) | 2003-01-10 | 2010-11-04 | Ablynx N.V. | Recombinant VHH single domain antibody from camelidae against von willebrand factor (vWF) or against collagen |
EP1437764A1 (en) * | 2003-01-10 | 2004-07-14 | S.O.I. Tec Silicon on Insulator Technologies S.A. | A compliant substrate for a heteroepitaxy, a heteroepitaxial structure and a method for fabricating a compliant substrate |
CA2521826C (en) | 2003-04-11 | 2013-08-06 | Jennifer L. Reed | Recombinant il-9 antibodies and uses thereof |
CA2529819A1 (en) | 2003-06-30 | 2004-09-23 | Domantis Limited | Pegylated single domain antibodies |
US7754209B2 (en) | 2003-07-26 | 2010-07-13 | Trubion Pharmaceuticals | Binding constructs and methods for use thereof |
EP3722309A1 (en) | 2003-07-28 | 2020-10-14 | Genentech, Inc. | Reducing protein a leaching during protein a affinity chromatography |
AU2004263896A1 (en) | 2003-08-08 | 2005-02-17 | Genenews Inc. | Osteoarthritis biomarkers and uses thereof |
AU2004316266A1 (en) * | 2003-09-30 | 2005-09-09 | Centocor, Inc. | Human hinge core mimetibodies, compositions, methods and uses |
BRPI0416243A (pt) | 2003-11-05 | 2007-01-09 | Palingen Inc | método de tratamento de um paciente humano que sofre de uma condição que inclui uma hiper-proliferação de células b; formulação farmacêutica para injeção parenteral; kit para o tratamento de um paciente que sofre de uma condição que inclui uma hiper-proliferação de células b; e método para purgar a medula óssea de um paciente que sofre de cáncer linfóide de células b malignas antes do reimplante da medula óssea no paciente após a terapia mieloablativa |
JP5060134B2 (ja) | 2003-12-12 | 2012-10-31 | ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ・アズ リプレゼンテッド バイ ザ セクレタリー・デパートメント オブ ヘルス アンド ヒューマン サービシーズ | ヒト細胞傷害性Tリンパ球のエピトープ及びそのMUC−1の非VNTR(non−variablenumberoftandemrepeatsequence)由来のアゴニストエピトープ |
US7785903B2 (en) | 2004-04-09 | 2010-08-31 | Genentech, Inc. | Variable domain library and uses |
WO2005105984A2 (en) * | 2004-04-12 | 2005-11-10 | The Trustees Of The University Of Pennsylvania | Culture conditions and growth factors affecting fate determination, self-renewal and expansion of mouse spermatogonial stem cells |
US20070298443A1 (en) * | 2004-06-04 | 2007-12-27 | Yiyou Chen | Screening Method Using Antibody Heavy Chains |
US20050276807A1 (en) * | 2004-06-15 | 2005-12-15 | Advanced Biotherapy, Inc. | Treatment of acne |
US20050276806A1 (en) * | 2004-06-15 | 2005-12-15 | Advanced Biotherapy, Inc. | Treatment of autism |
GB2416768A (en) * | 2004-07-22 | 2006-02-08 | Univ Erasmus | Heavy chain immunoglobulin complexes |
EP3272770B1 (en) | 2004-07-22 | 2023-12-20 | Erasmus University Medical Center Rotterdam | Method for the production of a vh heavy chain-only antibody in a transgenic mammal and binding polypeptide complex consisting of a dimer of a first chain and a second chain wherein each chain consists of two antigen-specific vh binding domains linked by a dimerisation domain |
US20060177445A1 (en) * | 2004-08-16 | 2006-08-10 | Boris Skurkovich | Treatment of inflammatory skin diseases |
US7563443B2 (en) * | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
CN101724071A (zh) | 2004-10-08 | 2010-06-09 | 杜门蒂斯有限公司 | 抗肿瘤坏死因子受体1的单域抗体及其使用方法 |
US7462454B2 (en) * | 2004-10-12 | 2008-12-09 | Advanced Biotherapy, Inc. | Treatment of herpes |
KR20070084170A (ko) * | 2004-10-13 | 2007-08-24 | 아블린쓰 엔.브이. | 알쯔하이머병 등의 퇴행성 신경 질환의 치료 및 진단을위한 단일 도메인 카멜리드 항-아밀로이드 베타 항체 및이를 포함하는 폴리펩타이드 |
WO2006047639A2 (en) | 2004-10-27 | 2006-05-04 | Medimmune, Inc. | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
PL1836500T3 (pl) | 2005-01-14 | 2010-12-31 | Ablynx Nv | Sposoby i testy do rozróżniania między różnymi postaciami chorób i zaburzeń cechujących się małopłytkowością i/lub samoistną interakcją między czynnikiem von Willebranda (vWF) a płytkami krwi |
EP1844073A1 (en) * | 2005-01-31 | 2007-10-17 | Ablynx N.V. | Method for generating variable domain sequences of heavy chain antibodies |
US7713695B2 (en) | 2005-02-07 | 2010-05-11 | Genenews, Inc. | Mild osteoarthritis biomarkers and uses thereof |
AU2006213686A1 (en) | 2005-02-09 | 2006-08-17 | Avi Bio Pharma, Inc. | Antisense composition and method for treating muscle atrophy |
US8349328B2 (en) | 2005-03-11 | 2013-01-08 | Syngenta Crop Protection Llc | Rodent control agents comprising antibodies that binds to rodent specific peptide epitopes |
US20060246524A1 (en) * | 2005-04-28 | 2006-11-02 | Christina Bauer | Nanoparticle conjugates |
CA2609702C (en) * | 2005-04-28 | 2013-05-28 | Ventana Medical Systems, Inc. | Antibody conjugates via heterobifunctional peg linkers |
CA2962819C (en) | 2005-05-18 | 2021-07-27 | Ablynx Nv | Improved nanobodies against human serum albumin |
NZ563392A (en) | 2005-05-20 | 2009-12-24 | Ablynx Nv | Improved Nanobodies(TM) for the treatment of aggregation-mediated disorders |
DE102005023617A1 (de) | 2005-05-21 | 2006-11-23 | Aspre Ag | Verfahren zum Mischen von Farben in einem Display |
ES2460517T3 (es) * | 2005-07-25 | 2014-05-13 | Emergent Product Development Seattle, Llc | Reducción de células b mediante el uso de moléculas de unión específica a cd37 y de unión específica a cd20 |
RS55788B1 (sr) | 2005-08-31 | 2017-08-31 | Merck Sharp & Dohme | Inženjerisana anti-il-23 antitela |
CN101296706B (zh) | 2005-09-01 | 2011-11-30 | 先灵公司 | Il-23和il-17拮抗剂治疗自身免疫性眼部炎性疾病的用途 |
EP1943341A4 (en) * | 2005-09-27 | 2010-07-07 | Ca Nat Research Council | HEMATOENCEPHALIC BARRIER EPITOPES AND USES THEREOF |
AU2006297304B2 (en) | 2005-09-29 | 2012-05-17 | Medimmune, Llc | Method of identifying membrane LG specific antibodies and use thereof for targeting immunoglobulin-producing precursor cells |
US7526409B2 (en) * | 2005-10-07 | 2009-04-28 | Oracle International Corporation | Automatic performance statistical comparison between two periods |
GB0521139D0 (en) | 2005-10-18 | 2005-11-23 | Univ Sheffield | Therapeutic agent |
EP1945816B1 (en) | 2005-10-21 | 2011-07-27 | GeneNews Inc. | Method and apparatus for correlating levels of biomarker products with disease |
GB0522460D0 (en) * | 2005-11-03 | 2005-12-14 | Prendergast Patrick T | Composition and method for the treatment of avian influenza |
CA2631005C (en) * | 2005-11-23 | 2017-02-28 | Ventana Medical Systems, Inc. | Molecular conjugate |
US10183986B2 (en) | 2005-12-15 | 2019-01-22 | Industrial Technology Research Institute | Trimeric collagen scaffold antibodies |
EP1983823A1 (en) | 2006-01-17 | 2008-10-29 | VIB vzw | Inhibitors of prolyl-hydroxylase 1 for the treatment of skeletal muscle degeneration |
AU2007209201A1 (en) * | 2006-01-24 | 2007-08-02 | Domantis Limited | Fusion proteins that contain natural junctions |
TWI417301B (zh) | 2006-02-21 | 2013-12-01 | Wyeth Corp | 對抗人類介白素-22(il-22)之抗體及其用途 |
TW200744634A (en) | 2006-02-21 | 2007-12-16 | Wyeth Corp | Methods of using antibodies against human IL-22 |
US7504106B2 (en) * | 2006-03-14 | 2009-03-17 | Boris Skurkovich | Method and composition for treatment of renal failure with antibodies and their equivalents as partial or complete replacement for dialysis |
US20100226920A1 (en) * | 2006-03-27 | 2010-09-09 | Ablynx N.V. | Medical delivery device for therapeutic proteins based on single domain antibodies |
WO2008054514A2 (en) * | 2006-04-21 | 2008-05-08 | Wyeth | Differential expression profiling analysis of cell culture phenotypes and the uses thereof |
CN101437945A (zh) | 2006-05-02 | 2009-05-20 | 阿克托杰尼斯有限公司 | 肥胖相关肽的微生物肠内递送 |
AU2007257692B2 (en) | 2006-06-12 | 2013-11-14 | Aptevo Research And Development Llc | Single-chain multivalent binding proteins with effector function |
EP2815764A1 (en) | 2006-06-14 | 2014-12-24 | Macrogenics, Inc. | Methods for the treatment of autoimmune disorders using monoclonal antibodies with reduced toxicity |
AU2007281876B2 (en) | 2006-06-26 | 2013-09-05 | Macrogenics, Inc. | FcgammaRIIB-specific antibodies and methods of use thereof |
EP2495307B9 (en) | 2006-07-13 | 2018-05-02 | Wyeth LLC | Production of coagulation factor IX with improved glycosylation pattern |
JP5209625B2 (ja) | 2006-08-28 | 2013-06-12 | 協和発酵キリン株式会社 | アンタゴニストのヒトlight特異的ヒトモノクローナル抗体 |
EP2698166B1 (en) | 2006-10-10 | 2015-09-30 | Regenesance B.V. | Complement inhibition for improved nerve regeneration |
GB0621513D0 (en) | 2006-10-30 | 2006-12-06 | Domantis Ltd | Novel polypeptides and uses thereof |
DK2442107T3 (da) | 2006-11-01 | 2014-05-19 | Ventana Med Syst Inc | Haptener, haptenkonjugater, sammensætninger deraf og fremgangsmåde til deres fremstilling og anvendelse |
EP2092080A1 (en) | 2006-11-07 | 2009-08-26 | Vib Vzw | Diagnosis and treatment of t-cell acute lymphoblastic leukemia |
MX2009005466A (es) | 2006-11-22 | 2009-08-17 | Adnexus A Bristol Myers Sqibb | Terapeuticos dirigidos a base de proteinas manipuladas para receptores de tirosina cinasas, incluyendo receptor de factor de crecimiento tipo insulina-i. |
AU2007328900A1 (en) * | 2006-12-05 | 2008-06-12 | Ablynx N.V. | Peptides capable of binding to serum proteins |
KR20090088950A (ko) | 2006-12-14 | 2009-08-20 | 쉐링 코포레이션 | 가공된 항-tslp 항체 |
WO2008074840A2 (en) | 2006-12-19 | 2008-06-26 | Ablynx N.V. | Amino acid sequences directed against a metalloproteinase from the adam family and polypeptides comprising the same for the treatment of adam-related diseases and disorders |
EP2557090A3 (en) | 2006-12-19 | 2013-05-29 | Ablynx N.V. | Amino acid sequences directed against GPCRs and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders |
US9023352B2 (en) | 2007-02-20 | 2015-05-05 | Tufts University | Methods, compositions and kits for treating a subject using a recombinant heteromultimeric neutralizing binding protein |
RS52345B (en) | 2007-02-23 | 2012-12-31 | Schering Corporation | ANTI-IL-23P19 ANTIBODY MANUFACTURED BY GENETIC ENGINEERING |
CN103396489A (zh) | 2007-02-23 | 2013-11-20 | 默沙东公司 | 工程改造的抗IL-23p19抗体 |
MX2009009167A (es) | 2007-02-28 | 2009-09-04 | Schering Corp | Terapia de combinacion para el tratamiento de trastornos inmunes. |
NZ579251A (en) | 2007-02-28 | 2012-06-29 | Schering Corp | Engineered anti-il-23r antibodies |
EP2924113B1 (en) | 2007-03-02 | 2019-04-10 | Wyeth LLC | Use of copper and glutamate in cell culture for production of polypeptides |
PT2308514E (pt) | 2007-03-23 | 2013-09-06 | To Bbb Holding B V | Conjugados para a administração orientada de medicamentos através da barreira hematoencefálica |
TW200902708A (en) | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
AU2008246442B2 (en) | 2007-05-04 | 2014-07-03 | Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa | Engineered rabbit antibody variable domains and uses thereof |
CA2986531C (en) | 2007-05-14 | 2020-02-25 | Astrazeneca Ab | Methods of reducing eosinophil levels |
CA2687178C (en) | 2007-05-23 | 2014-02-04 | Ventana Medical Systems, Inc. | Polymeric carriers for immunohistochemistry and in situ hybridization |
EP2602323B1 (en) | 2007-06-01 | 2018-02-28 | Open Monoclonal Technology, Inc. | Compositions and methods for inhibiting endogenous immunoglobin genes and producing transgenic human idiotype antibodies |
WO2008157299A2 (en) * | 2007-06-15 | 2008-12-24 | Wyeth | Differential expression profiling analysis of cell culture phenotypes and uses thereof |
EP2173772A2 (en) | 2007-07-03 | 2010-04-14 | Ablynx N.V. | Providing improved immunoglobulin sequences by mutating cdr and/or fr positions |
EP2487190A3 (en) | 2007-07-13 | 2012-11-14 | Bac Ip B.V. | Single-domain antigen-binding proteins that bind mammalian IgG |
US20100291593A1 (en) | 2007-07-13 | 2010-11-18 | Powell William C | Method of identifying diagnostic reagents |
WO2009023562A2 (en) | 2007-08-09 | 2009-02-19 | Wyeth | Use of perfusion to enhance production of fed-batch cell culture in bioreactors |
US8629246B2 (en) | 2007-09-26 | 2014-01-14 | Ucb Pharma S.A. | Dual specificity antibody fusions |
TWI489993B (zh) | 2007-10-12 | 2015-07-01 | Novartis Ag | 骨硬化素(sclerostin)抗體組合物及使用方法 |
CN101918579A (zh) | 2007-10-22 | 2010-12-15 | 先灵公司 | 完全人抗-vegf抗体和使用方法 |
JP5514399B2 (ja) * | 2007-11-02 | 2014-06-04 | 国立大学法人 岡山大学 | 無機硫黄化合物加水分解酵素の製造方法 |
CA2700433A1 (en) | 2007-11-02 | 2009-05-07 | Novartis Ag | Molecules and methods for modulating low-density-lipoprotein receptor-related protein 6 (lrp6) |
CA2960659C (en) | 2007-11-09 | 2021-07-13 | The Salk Institute For Biological Studies | Use of tam receptor inhibitors as immunoenhancers and tam activators as immunosuppressors |
JP2011504740A (ja) * | 2007-11-27 | 2011-02-17 | アブリンクス エン.ヴェー. | ヘテロ二量体サイトカイン及び/又はこれらの受容体に指向性を有するアミノ酸配列、並びにこれを含むポリペプチド |
US9308257B2 (en) | 2007-11-28 | 2016-04-12 | Medimmune, Llc | Protein formulation |
WO2009086215A2 (en) * | 2007-12-21 | 2009-07-09 | Wyeth | Pathway analysis of cell culture phenotypes and uses thereof |
WO2009099961A2 (en) | 2008-01-31 | 2009-08-13 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Engineered antibody constant domain molecules |
WO2009109635A2 (en) | 2008-03-05 | 2009-09-11 | Ablynx Nv | Novel antigen binding dimer-complexes, methods of making and uses thereof |
US9908943B2 (en) | 2008-04-03 | 2018-03-06 | Vib Vzw | Single domain antibodies capable of modulating BACE activity |
GB0809069D0 (en) | 2008-05-19 | 2008-06-25 | Univ Leuven Kath | Gene signatures |
DK2281005T3 (en) | 2008-04-03 | 2014-02-24 | Vib Vzw | Single domain antibodies able to modulate bace1 activity |
US8557965B2 (en) | 2008-04-07 | 2013-10-15 | Ablynx N.V. | Single variable domains against notch pathway members |
DK2132228T3 (da) | 2008-04-11 | 2011-10-10 | Emergent Product Dev Seattle | CD37-immunterapeutisk middel og kombination med bifunktionelt kemoterapeutisk middel deraf |
US8217140B2 (en) | 2008-04-17 | 2012-07-10 | Ablynx N.V. | Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same |
ES2620285T3 (es) | 2008-05-02 | 2017-06-28 | Novartis Ag | Moléculas de unión con base en fibronectina mejorada y usos de las mismas |
EP2799448A1 (en) | 2008-05-22 | 2014-11-05 | Bristol-Myers Squibb Company | Multivalent fibronectin based scaffold domain proteins |
CA2720728C (en) | 2008-06-05 | 2018-04-03 | Ventana Medical Systems, Inc. | Compositions comprising nanomaterials and method for using such compositions for histochemical processes |
GB2461546B (en) * | 2008-07-02 | 2010-07-07 | Argen X Bv | Antigen binding polypeptides |
US8444976B2 (en) | 2008-07-02 | 2013-05-21 | Argen-X B.V. | Antigen binding polypeptides |
HUE029982T2 (en) | 2008-07-18 | 2017-04-28 | Bristol Myers Squibb Co | Monovalent compositions and methods of use for CD28 binding |
AU2009273251B2 (en) | 2008-07-22 | 2014-12-18 | Ablynx Nv | Amino acid sequences directed against multitarget scavenger receptors and polypeptides |
CA2732782C (en) | 2008-08-05 | 2019-02-26 | Novartis Ag | Compositions and methods for antibodies targeting complement protein c5 |
US20100136584A1 (en) * | 2008-09-22 | 2010-06-03 | Icb International, Inc. | Methods for using antibodies and analogs thereof |
US20100092470A1 (en) * | 2008-09-22 | 2010-04-15 | Icb International, Inc. | Antibodies, analogs and uses thereof |
US20100075329A1 (en) | 2008-09-23 | 2010-03-25 | O'toole Margot | Methods for predicting production of activating signals by cross-linked binding proteins |
MX345226B (es) | 2008-10-29 | 2017-01-20 | Ablynx Nv | Formulaciones de moleculas de union a antigeno de dominio sencillo. |
CN102272154A (zh) | 2008-10-29 | 2011-12-07 | 惠氏有限责任公司 | 单域抗原结合性分子的纯化方法 |
WO2010070145A2 (en) | 2008-12-19 | 2010-06-24 | Ablynx N.V. | Method for generation of immunoglobulin sequences |
US20110250644A1 (en) | 2008-12-19 | 2011-10-13 | Schering Corporation | Feed supplement for mammalian cell culture and methods of use |
ES2701649T3 (es) | 2009-01-14 | 2019-02-25 | Ablynx Nv | Administración pulmonar de dominios variables individuales de inmunoglobulina y constructos de los mismos |
US20100189919A1 (en) * | 2009-01-27 | 2010-07-29 | Xerox Corporation | Imaging System And Process Using Monoclonal Antibodies |
CA2750520C (en) | 2009-02-04 | 2017-12-05 | Molecular Innovations | Methods for screening candidate agents for modulating prorenin and renin, assays for detecting prorenin, and antibodies used therein |
EP2403873A1 (en) | 2009-03-05 | 2012-01-11 | Ablynx N.V. | Novel antigen binding dimer-complexes, methods of making/avoiding and uses thereof |
EP2230515B1 (en) | 2009-03-16 | 2014-12-17 | Agilent Technologies, Inc. | Passivation of surfaces after ligand coupling |
GB0905023D0 (en) | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
CA2754393C (en) | 2009-03-24 | 2015-10-27 | Wyeth Llc | Membrane evaporation for generating highly concentrated protein therapeutics |
WO2010112458A1 (en) | 2009-03-31 | 2010-10-07 | Novartis Ag | Composition and methods of use for therapeutic antibodies specific for the il-12 receptore betal subunit |
WO2010115998A2 (en) | 2009-04-10 | 2010-10-14 | Ablynx Nv | Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders |
MY153078A (en) | 2009-04-27 | 2014-12-31 | Novartis Ag | Compositions and methods for increasing muscle growth |
PT2424889E (pt) | 2009-04-30 | 2015-11-12 | Ablynx Nv | Método de produção de anticorpos de domínio |
EP2432499A2 (en) | 2009-05-20 | 2012-03-28 | Schering Corporation | Modulation of pilr receptors to treat microbial infections |
CN105061592A (zh) | 2009-06-05 | 2015-11-18 | 埃博灵克斯股份有限公司 | 用于预防和/或治疗呼吸道感染的单价、二价和三价抗人呼吸道合胞病毒(hrsv)纳米抗体构建体 |
WO2011000054A1 (en) | 2009-07-03 | 2011-01-06 | Avipep Pty Ltd | Immuno-conjugates and methods for producing them |
US9150640B2 (en) | 2009-07-10 | 2015-10-06 | Ablynx N.V. | Method for the production of variable domains |
EP2459053A2 (en) | 2009-07-28 | 2012-06-06 | F. Hoffmann-La Roche AG | Non-invasive in vivo optical imaging method |
WO2011014438A1 (en) | 2009-07-31 | 2011-02-03 | N.V. Organon | Fully human antibodies to btla |
WO2011018421A1 (en) | 2009-08-10 | 2011-02-17 | Morphosys Ag | Novel screening strategies for the identification of binders |
LT2805731T (lt) | 2009-09-03 | 2019-02-11 | Ablynx N.V. | Stabilios polipeptidų kompozicijos ir jų panaudojimas |
RU2646139C1 (ru) | 2009-09-03 | 2018-03-01 | Мерк Шарп И Доум Корп. | Анти-gitr-антитела |
HUE028878T2 (en) | 2009-09-03 | 2017-01-30 | Cancer Res Tech Ltd | CLEC14A inhibitors |
WO2011029823A1 (en) | 2009-09-09 | 2011-03-17 | Novartis Ag | Monoclonal antibody reactive with cd63 when expressed at the surface of degranulated mast cells |
GB201005063D0 (en) | 2010-03-25 | 2010-05-12 | Ucb Pharma Sa | Biological products |
US20110172398A1 (en) | 2009-10-02 | 2011-07-14 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules for anti-angiogenesis therapy |
US20110195494A1 (en) | 2009-10-02 | 2011-08-11 | Boehringer Ingelheim International Gmbh | Dll4-binging molecules |
WO2011042398A1 (en) | 2009-10-09 | 2011-04-14 | Ablynx Nv | Immunoglobulin single variable domain directed against human cxcr4 and other cell associated proteins and methods to generate them |
WO2011045079A1 (en) | 2009-10-15 | 2011-04-21 | Intercell Ag | Hepatitis b virus specific human antibodies |
DK2491056T3 (da) | 2009-10-22 | 2021-10-25 | Univ Twente | Vhh til anvendelse i vævsreparation, organregenerering, organudskiftning og vævskonstruktion |
MX2012003198A (es) | 2009-10-23 | 2012-06-12 | Millennium Pharm Inc | Moleculas de anticuerpo anti-gcc y composiciones y metodos relacionados. |
EP3434769B1 (en) | 2009-10-30 | 2020-11-25 | Novartis AG | Universal fibronectin type iii bottom-side binding domain libraries |
WO2011051327A2 (en) | 2009-10-30 | 2011-05-05 | Novartis Ag | Small antibody-like single chain proteins |
WO2011051466A1 (en) | 2009-11-02 | 2011-05-05 | Novartis Ag | Anti-idiotypic fibronectin-based binding molecules and uses thereof |
MY162511A (en) | 2009-11-04 | 2017-06-15 | Merck Sharp & Dohme | Engineered anti-tslp antibody |
CN102640001A (zh) | 2009-11-05 | 2012-08-15 | 诺瓦提斯公司 | 预测纤维化进展的生物标记物 |
EP2507262A1 (en) | 2009-11-30 | 2012-10-10 | Ablynx N.V. | Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
JP5909449B2 (ja) | 2009-12-10 | 2016-04-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | 重鎖抗体を作製するマウス |
US20110150885A1 (en) | 2009-12-11 | 2011-06-23 | Atyr Pharma, Inc. | Aminoacyl trna synthetases for modulating hematopoiesis |
US8962807B2 (en) | 2009-12-14 | 2015-02-24 | Ablynx N.V. | Single variable domain antibodies against OX40L, constructs and therapeutic use |
US8691227B2 (en) | 2009-12-17 | 2014-04-08 | Merck Sharp & Dohme Corp. | Methods of treating multiple sclerosis, rheumatoid arthritis and inflammatory bowel disease using agonists antibodies to PILR-α |
US9315581B2 (en) | 2009-12-23 | 2016-04-19 | A Vipep Pty Limited | Immuno-conjugates and methods for producing them |
WO2011083140A1 (en) | 2010-01-08 | 2011-07-14 | Ablynx Nv | Immunoglobulin single variable domain directed against human cxcr4 |
TWI513466B (zh) | 2010-01-20 | 2015-12-21 | Boehringer Ingelheim Int | 抗凝血劑解毒劑 |
CN102781959A (zh) | 2010-02-05 | 2012-11-14 | 埃博灵克斯股份有限公司 | 能够结合血清白蛋白的肽和包含所述肽的化合物、构建体和多肽 |
IN2012DN06588A (ja) | 2010-02-10 | 2015-10-23 | Novartis Ag | |
US9120855B2 (en) | 2010-02-10 | 2015-09-01 | Novartis Ag | Biologic compounds directed against death receptor 5 |
PT3501499T (pt) | 2010-02-11 | 2022-11-22 | Ablynx Nv | Métodos e composições para a preparação de aerossóis |
US20130012916A1 (en) | 2010-02-11 | 2013-01-10 | Glide Pharmaceutical Technologies Limited | Delivery of immunoglobulin variable domains and constructs thereof |
DK2539355T3 (da) | 2010-02-26 | 2017-01-02 | Ventana Med Syst Inc | IN-SITU-hybridisering med polytag-prober |
PE20130527A1 (es) | 2010-03-03 | 2013-05-09 | Boehringer Ingelheim Int | Polipeptidos de union a a-beta biparatopicos |
EP2552962B1 (en) | 2010-03-26 | 2016-03-23 | Ablynx N.V. | Immunoglobulin single variable domains directed against cxcr7 |
EP2553449A2 (en) | 2010-03-26 | 2013-02-06 | Westfälische Wilhelms-Universität Münster | Substitute therapy for glucocorticoids |
US9556273B2 (en) | 2010-03-29 | 2017-01-31 | Vib Vzw | Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages |
WO2013174537A1 (en) | 2012-05-24 | 2013-11-28 | Vib Vzw | Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages |
US9101674B2 (en) | 2010-03-29 | 2015-08-11 | Vib Vzw | Targeting and in vivo imaging of tumor-associated macrophages |
AU2011237873B2 (en) | 2010-04-06 | 2015-01-29 | Biotalys NV | Specific delivery of agrochemicals |
GB201105584D0 (en) | 2011-04-01 | 2011-05-18 | Imp Innovations Ltd | Cancer methods |
US20130034853A1 (en) | 2010-04-20 | 2013-02-07 | Brian Kelly | Two-color chromogenic in situ hybridization |
AU2011248625B2 (en) | 2010-04-26 | 2017-01-05 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase |
EP2563381B1 (en) | 2010-04-27 | 2017-08-09 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl trna synthetases |
CN103097524B (zh) | 2010-04-28 | 2016-08-03 | Atyr医药公司 | 与丙氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
AU2011248490B2 (en) | 2010-04-29 | 2016-11-10 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases |
CN103118693B (zh) | 2010-04-29 | 2017-05-03 | Atyr 医药公司 | 与缬氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
WO2011137395A1 (en) | 2010-04-30 | 2011-11-03 | Rother Russell P | Anti-c5a antibodies and methods for using the antibodies |
WO2011140132A2 (en) | 2010-05-03 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases |
ES2668207T3 (es) | 2010-05-03 | 2018-05-17 | Atyr Pharma, Inc. | Descubrimiento innovador de composiciones terapéuticas, de diagnóstico y de anticuerpos relacionadas con fragmentos de proteínas de metionil-ARNt sintetasas |
CN103096925A (zh) | 2010-05-03 | 2013-05-08 | Atyr医药公司 | 与精氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
US8877188B2 (en) | 2010-05-04 | 2014-11-04 | The Brigham And Women's Hospital, Inc. | Detection and treatment of non-dermal fibrosis |
US9062302B2 (en) | 2010-05-04 | 2015-06-23 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-tRNA synthetase complex |
WO2011140173A1 (en) | 2010-05-04 | 2011-11-10 | The Brigham And Women's Hospital, Inc. | Detection and treatment of fibrosis |
EP2566894A1 (en) | 2010-05-06 | 2013-03-13 | Novartis AG | Compositions and methods of use for therapeutic low density lipoprotein - related protein 6 (lrp6) multivalent antibodies |
SG185416A1 (en) | 2010-05-06 | 2012-12-28 | Novartis Ag | Compositions and methods of use for therapeutic low density lipoprotein -related protein 6 (lrp6) antibodies |
JP6145404B2 (ja) | 2010-05-07 | 2017-06-14 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | エクスビボでの細胞の検出のための診断的方法 |
CN103200953B (zh) | 2010-05-14 | 2017-02-15 | Atyr 医药公司 | 与苯丙氨酰‑β‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
SG185354A1 (en) | 2010-05-20 | 2012-12-28 | Ablynx Nv | Biological materials related to her3 |
AU2011258106B2 (en) | 2010-05-27 | 2017-02-23 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases |
SG186397A1 (en) | 2010-06-22 | 2013-01-30 | Univ Colorado Regents | Antibodies to the c3d fragment of complement component 3 |
WO2011161263A1 (en) | 2010-06-25 | 2011-12-29 | Ablynx Nv | Pharmaceutical compositions for cutaneous administration |
CA2805548A1 (en) | 2010-07-02 | 2012-01-05 | Vib Vzw | The role of fragile x mental retardation gene and protein in cancer metastasis |
WO2012003476A2 (en) | 2010-07-02 | 2012-01-05 | Ventana Medical Systems, Inc. | Hapten conjugates for target detection |
WO2012021247A2 (en) | 2010-07-12 | 2012-02-16 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases |
GB201014715D0 (en) | 2010-09-06 | 2010-10-20 | Vib Vzw | Nanobodies stabilizing functional conformational states of GPCRS |
JP2013536175A (ja) | 2010-07-16 | 2013-09-19 | アブリンクス エン.ヴェー. | 修飾された単一ドメイン抗原結合分子及びその使用 |
GB201012845D0 (en) | 2010-07-30 | 2010-09-15 | Vib Vzw | Inhibition of dicer function for treatment of cancer |
LT2601298T (lt) | 2010-08-02 | 2017-03-10 | Regeneron Pharmaceuticals, Inc. | Pelė, kuri gamina rišančius baltymus, apimančius vl domenus |
DK2606055T3 (en) | 2010-08-16 | 2015-09-07 | Ventana Med Syst Inc | Chromogenic detection substrates and methods for use in detection assays and kits |
CA2807607A1 (en) | 2010-08-20 | 2012-02-23 | Wyeth Llc | Cell culture of growth factor-free adapted cells |
BR112013004012B1 (pt) | 2010-08-20 | 2021-03-23 | Novartis Ag | Anticorpo monoclonal isolado ou fragmento de ligação ao antígeno do mesmo ao receptor her3, seu uso e composição farmacêutica |
WO2012027611A2 (en) | 2010-08-25 | 2012-03-01 | Atyr Pharma, Inc. | INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF TYROSYL-tRNA SYNTHETASES |
WO2012025602A1 (en) | 2010-08-26 | 2012-03-01 | Vib Vzw | Insect binding antibodies |
US9516879B2 (en) | 2010-08-26 | 2016-12-13 | Agrosavfe N.V. | Chitinous polysaccharide antigen-binding proteins |
US20120225081A1 (en) | 2010-09-03 | 2012-09-06 | Boehringer Ingelheim International Gmbh | Vegf-binding molecules |
US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
WO2012042026A1 (en) | 2010-09-30 | 2012-04-05 | Ablynx Nv | Biological materials related to c-met |
CN103154037A (zh) | 2010-10-05 | 2013-06-12 | 诺瓦提斯公司 | 抗IL12Rβ1抗体及它们在治疗自身免疫病和炎性疾病中的用途 |
DK2632946T3 (en) | 2010-10-29 | 2018-03-12 | Ablynx Nv | PROCEDURE FOR MANUFACTURING VARIABLE IMMUNGLOBULIN SINGLE DOMAINS |
GB201018602D0 (en) | 2010-11-04 | 2010-12-22 | Vib Vzw | MMP8 inactivating antigen binding proteins |
SG10201509145XA (en) | 2010-11-05 | 2015-12-30 | Morphotek Inc | Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers |
SG189981A1 (en) | 2010-11-08 | 2013-06-28 | Novartis Ag | Cxcr2 binding polypeptides |
WO2012084895A2 (en) | 2010-12-20 | 2012-06-28 | Universiteit Gent | Crystal structure of flt3 ligand-receptor complex |
EP2659000B1 (en) | 2010-12-30 | 2016-08-10 | Ventana Medical Systems, Inc. | Enhanced deposition of chromogens utilizing pyrimidine analogs |
US9598499B2 (en) | 2010-12-30 | 2017-03-21 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Antigen binding formats for use in therapeutic treatments or diagnostic assays |
WO2012103165A2 (en) | 2011-01-26 | 2012-08-02 | Kolltan Pharmaceuticals, Inc. | Anti-kit antibodies and uses thereof |
WO2012105833A1 (en) | 2011-02-01 | 2012-08-09 | Bac Ip B.V. | Antigen-binding protein directed against epitope in the ch1 domain of human igg antibodies |
CA2826453A1 (en) | 2011-02-03 | 2012-08-09 | Alexion Pharmaceuticals, Inc. | Use of an anti-cd200 antibody for prolonging the survival of allografts |
EP2683290B1 (en) | 2011-03-07 | 2018-11-07 | F.Hoffmann-La Roche Ag | Methods for in vivo testing of therapeutic antibodies |
EP2683413A1 (en) | 2011-03-07 | 2014-01-15 | F.Hoffmann-La Roche Ag | In vivo selection of therapeutically active antibodies |
CN103534359B (zh) | 2011-03-14 | 2016-07-06 | 文塔纳医疗系统公司 | 分析染色体易位的方法及其系统 |
WO2012122590A1 (en) | 2011-03-14 | 2012-09-20 | Cellmid Limited | Antibody recognizing n-domain of midkine |
AU2012234284B2 (en) | 2011-03-28 | 2015-10-08 | Ablynx Nv | Bispecific anti-CXCR7 immunoglobulin single variable domains |
EP2691415B1 (en) | 2011-03-28 | 2018-07-11 | Ablynx N.V. | Method for producing solid formulations comprising immunoglobulin single variable domains |
KR20140009437A (ko) | 2011-03-30 | 2014-01-22 | 베링거 인겔하임 인터내셔날 게엠베하 | 항응고제 해독제 |
JP6130350B2 (ja) | 2011-03-30 | 2017-05-17 | アブリンクス エン.ヴェー. | TNFαに対する単一ドメイン抗体で免疫障害を処置する方法 |
WO2012135408A1 (en) | 2011-03-31 | 2012-10-04 | Merck Sharp & Dohme Corp. | Stable formulations of antibodies to human programmed death receptor pd-1 and related treatments |
US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
US20130078247A1 (en) | 2011-04-01 | 2013-03-28 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to dii4 and ang2 |
ES2669310T3 (es) | 2011-04-20 | 2018-05-24 | Medimmune, Llc | Anticuerpos y otras moléculas que se unen con B7-H1 y PD-1 |
UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
EP3590950A1 (en) | 2011-05-09 | 2020-01-08 | Ablynx NV | Method for the production of immunoglobulin single varible domains |
CN107903325B (zh) | 2011-05-16 | 2021-10-29 | 埃泰美德(香港)有限公司 | 多特异性fab融合蛋白及其使用方法 |
RU2661677C2 (ru) | 2011-05-27 | 2018-07-18 | Аблинкс Нв | Ингибирование резорбции кости с помощью связывающих rank-l пептидов |
WO2012166906A1 (en) | 2011-05-31 | 2012-12-06 | Massachusetts Institute Of Technology | Cell-directed synthesis of multifunctional nanopatterns and nanomaterials |
EP2718326B1 (en) | 2011-06-13 | 2020-08-19 | CSL Limited | Antibodies against g-csfr and uses thereof |
WO2012172495A1 (en) | 2011-06-14 | 2012-12-20 | Novartis Ag | Compositions and methods for antibodies targeting tem8 |
CN104053667B (zh) | 2011-06-21 | 2017-09-15 | 非营利性组织佛兰芒综合大学生物技术研究所 | 针对gpcr:g蛋白复合物的结合结构域及来自其的用途 |
EP4218933A1 (en) | 2011-06-23 | 2023-08-02 | Ablynx NV | Serum albumin binding proteins |
IN2014CN00437A (ja) | 2011-06-23 | 2015-04-03 | Ablynx Nv | |
EP2726099B1 (en) | 2011-07-01 | 2018-07-25 | Novartis AG | Method for treating metabolic disorders |
GB201112056D0 (en) | 2011-07-14 | 2011-08-31 | Univ Leuven Kath | Antibodies |
EP2731970B1 (en) | 2011-07-15 | 2018-11-28 | MorphoSys AG | Antibodies that are cross-reactive for macrophage migration inhibitory factor (mif) and d-dopachrome tautomerase (d-dt) |
UY34254A (es) | 2011-08-17 | 2013-04-05 | Glaxo Group Ltd | Proteínas y péptidos modificados. |
US9435812B2 (en) | 2011-08-31 | 2016-09-06 | Ventana Medical Systems, Inc. | Expression of ETS related gene (ERG) and phosphatase and tensin homolog (PTEN) correlates with prostate cancer capsular penetration |
GB201115529D0 (en) | 2011-09-08 | 2011-10-26 | Imp Innovations Ltd | Antibodies, uses and methods |
WO2013036130A1 (en) | 2011-09-09 | 2013-03-14 | Universiteit Utrecht Holding B.V. | Broadly neutralizing vhh against hiv-1 |
EP3311661B1 (en) | 2011-09-19 | 2022-04-20 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
WO2013041901A1 (en) | 2011-09-20 | 2013-03-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for preparing single domain antibody microarrays |
EP3311837A1 (en) | 2011-09-23 | 2018-04-25 | Ablynx NV | Prolonged inhibition of interleukin-6 mediated signaling |
WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
CA2850261C (en) | 2011-09-30 | 2021-04-20 | Ablynx Nv | C-met immunoglobulin single variable domains |
US20130085139A1 (en) | 2011-10-04 | 2013-04-04 | Royal Holloway And Bedford New College | Oligomers |
US9296826B2 (en) | 2011-10-14 | 2016-03-29 | Novartis Ag | Antibodies and methods for WNT pathway-related diseases |
WO2013059206A2 (en) | 2011-10-17 | 2013-04-25 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Monospecific and bispecific human monoclonal antibodies targeting insulin-growth factor ii (igf-ii) |
GB2496375A (en) | 2011-10-28 | 2013-05-15 | Kymab Ltd | A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof |
EP2771351B1 (en) | 2011-10-28 | 2017-06-14 | Patrys Limited | Pat-lm1 epitopes and methods for using same |
BR112014011304B1 (pt) | 2011-11-11 | 2022-03-03 | UCB Biopharma SRL | Anticorpos de ligação com albumina e fragmentos de ligação dos mesmos, proteína de fusão de anticorpo bi-específico, polinucleotídeo, célula hospedeira, processo de produção de anticorpo ou fragamento do mesmo, formulação farmacêutica e uso |
WO2013079606A1 (en) | 2011-12-01 | 2013-06-06 | Ventana Medical Systems, Inc. | Automated dual stain of mirna and protein targets |
US20150147274A1 (en) | 2011-12-02 | 2015-05-28 | Cancer Research Technology Limited | Antibodies against hgf - receptor and uses |
GB201122047D0 (en) | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
EP2788382A2 (en) | 2011-12-05 | 2014-10-15 | Novartis AG | Antibodies for epidermal growth factor receptor 3 (her3) directed to domain ii of her3 |
SG11201402783YA (en) | 2011-12-05 | 2014-06-27 | Novartis Ag | Antibodies for epidermal growth factor receptor 3 (her3) |
EP3330288A1 (en) | 2011-12-21 | 2018-06-06 | Novartis AG | Compositions and methods for antibodies targeting factor p |
US10112987B2 (en) | 2012-01-09 | 2018-10-30 | Icb International, Inc. | Blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an amyloid-beta peptide |
US10112988B2 (en) | 2012-01-09 | 2018-10-30 | Icb International, Inc. | Methods of assessing amyloid-beta peptides in the central nervous system by blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an anti-amyloid-beta peptide |
WO2013108126A2 (en) | 2012-01-16 | 2013-07-25 | University Of Oslo | Methyltransferases and uses thereof |
LT2804878T (lt) | 2012-01-20 | 2018-12-10 | Genzyme Corporation | Anti-cxcr3 antikūnai |
WO2013113696A1 (en) | 2012-01-30 | 2013-08-08 | Vib Vzw | Means and method for diagnosis and treatment of alzheimer's disease |
WO2013121042A1 (en) | 2012-02-16 | 2013-08-22 | Vib Vzw | PP2A SUBUNITS IN DNA REPAIR, THE PP2A B55α SUBUNIT AS NOVEL PHD2 INTERACTING PROTEIN, AND IMPLICATIONS FOR CANCER |
EP2820046B1 (en) | 2012-02-27 | 2022-06-15 | Ablynx N.V. | Cx3cr1-binding polypeptides |
US9592289B2 (en) | 2012-03-26 | 2017-03-14 | Sanofi | Stable IgG4 based binding agent formulations |
WO2013148498A1 (en) | 2012-03-27 | 2013-10-03 | Ventana Medical Systems, Inc. | Signaling conjugates and methods of use |
JP5970734B2 (ja) | 2012-03-30 | 2016-08-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ang2結合分子 |
US9156915B2 (en) | 2012-04-26 | 2015-10-13 | Thomas Jefferson University | Anti-GCC antibody molecules |
US9328174B2 (en) | 2012-05-09 | 2016-05-03 | Novartis Ag | Chemokine receptor binding polypeptides |
EP2687595B1 (en) | 2012-07-19 | 2018-05-30 | Laboratoire Français du Fractionnement et des Biotechnologies | Method for purifying transgenic factor VII |
TWI596113B (zh) | 2012-07-25 | 2017-08-21 | 塞爾德克斯醫療公司 | 抗kit抗體及其用途 |
CA2879542A1 (en) | 2012-07-25 | 2014-01-30 | Salk Institute For Biological Studies | Regulating the interaction between tam ligands and lipid membranes with exposed phosphatidylserine |
US9605074B2 (en) | 2012-08-30 | 2017-03-28 | The General Hospital Corporation | Multifunctional nanobodies for treating cancer |
UA118441C2 (uk) | 2012-10-08 | 2019-01-25 | Протена Біосаєнсиз Лімітед | Антитіло, що розпізнає альфа-синуклеїн |
CN109364250A (zh) | 2012-10-09 | 2019-02-22 | 比奥根Ma公司 | 联合治疗及用于治疗脱髓鞘病症的用途 |
LT2922962T (lt) | 2012-11-20 | 2017-04-10 | Novartis Ag | Optimizuota raiškos kasetė, skirta polipeptido raiškai su didele išeiga |
WO2014084859A1 (en) | 2012-11-30 | 2014-06-05 | Novartis Ag | Molecules and methods for modulating tmem16a activities |
SG11201503567SA (en) | 2012-12-05 | 2015-06-29 | Novartis Ag | Compositions and methods for antibodies targeting epo |
WO2014087010A1 (en) | 2012-12-07 | 2014-06-12 | Ablynx N.V. | IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE |
CN104994729B (zh) | 2012-12-14 | 2019-01-11 | Omt公司 | 编码具有人独特型的啮齿动物抗体的多核苷酸以及包含所述多核苷酸的动物 |
AU2013362909A1 (en) | 2012-12-18 | 2015-05-21 | Novartis Ag | Compositions and methods that utilize a peptide tag that binds to hyaluronan |
JP2016505843A (ja) | 2012-12-19 | 2016-02-25 | アンプリミューン, インコーポレイテッド | B7−h4特異的抗体、並びにその組成物及び使用方法 |
AU2013204922B2 (en) | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
CA2896091C (en) | 2012-12-21 | 2018-06-19 | Amplimmune, Inc. | Anti-h7cr antibodies |
AR093984A1 (es) | 2012-12-21 | 2015-07-01 | Merck Sharp & Dohme | Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano |
PL2951201T3 (pl) | 2013-01-30 | 2018-03-30 | Vib Vzw | Nowe polipeptydy chimeryczne do celów badań przesiewowych i odkrywania leków |
WO2014120916A1 (en) | 2013-02-01 | 2014-08-07 | Bristol-Myers Squibb Company | Pegylated domain antibodies monovalent for cd28 binding and methods of use |
DK2953973T3 (da) | 2013-02-05 | 2019-08-12 | Vib Vzw | Muskarine acetylcholinreceptor-bindemidler og anvendelser deraf |
EP4219552A3 (en) | 2013-02-07 | 2023-09-13 | CSL Ltd. | Il-11r binding proteins and uses thereof |
AU2014213599C1 (en) | 2013-02-08 | 2017-09-07 | Novartis Ag | Anti-IL-17A antibodies and their use in treating autoimmune and inflammatory disorders |
JP6499087B2 (ja) | 2013-02-26 | 2019-04-10 | ロシュ グリクアート アーゲー | 二重特異性t細胞活性化抗原結合分子 |
EP2962100B1 (en) | 2013-02-28 | 2021-07-28 | Caprion Proteomics Inc. | Tuberculosis biomarkers and uses thereof |
CA2900842C (en) | 2013-03-12 | 2020-01-21 | Ventana Medical Systems, Inc. | Digitally enhanced microscopy for multiplexed histology |
CA2902026C (en) | 2013-03-13 | 2023-08-29 | Prothena Biosciences Limited | Tau immunotherapy |
EP3611189A1 (en) | 2013-03-14 | 2020-02-19 | Novartis AG | Antibodies against notch 3 |
JP6493692B2 (ja) | 2013-03-15 | 2019-04-10 | セルジーン コーポレイション | 修飾されたtリンパ球 |
CA2906259C (en) | 2013-03-15 | 2022-12-06 | Vib Vzw | Anti-mmr single variable domains for prognosis and monitoring of cardiovascular diseases |
US10160797B2 (en) | 2013-03-15 | 2018-12-25 | Sanofi Pasteur Biologics, Llc | Antibodies against Clostridium difficile toxins and methods of using the same |
WO2014141192A1 (en) | 2013-03-15 | 2014-09-18 | Erasmus University Medical Center | Generation of heavy chain-only antibodies |
US9745368B2 (en) | 2013-03-15 | 2017-08-29 | The Trustees Of The University Of Pennsylvania | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
EP2976362B1 (en) | 2013-03-19 | 2019-10-23 | Beijing Shenogen Pharma Group Ltd. | Antibodies and methods for treating estrogen receptor-associated diseases |
US9803003B2 (en) | 2013-04-29 | 2017-10-31 | Agrosavfe N.V. | Agrochemical compositions comprising antibodies binding to sphingolipids |
US10000556B2 (en) | 2013-05-09 | 2018-06-19 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Single-domain VHH antibodies directed to norovirus GI.1 and GII.4 and their use |
NL1040254C2 (en) | 2013-05-17 | 2014-11-24 | Ablynx Nv | Stable formulations of immunoglobulin single variable domains and uses thereof. |
JP6682426B2 (ja) | 2013-05-24 | 2020-04-15 | メディミューン,エルエルシー | 抗b7−h5抗体およびその使用 |
WO2014194293A1 (en) | 2013-05-30 | 2014-12-04 | Amplimmune, Inc. | Improved methods for the selection of patients for pd-1 or b7-h4 targeted therapies, and combination therapies thereof |
JP6824735B2 (ja) | 2013-06-06 | 2021-02-03 | ピエール、ファーブル、メディカマン | 抗C10orf54抗体およびその使用方法 |
US9562101B2 (en) | 2013-06-21 | 2017-02-07 | Novartis Ag | Lectin-like oxidized LDL receptor 1 antibodies and methods of use |
AR096601A1 (es) | 2013-06-21 | 2016-01-20 | Novartis Ag | Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso |
US10202433B2 (en) | 2013-06-27 | 2019-02-12 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | IL-15 mutant polypeptides as IL-15 antagonists and encoding nucleic acids |
US20160176943A1 (en) | 2013-07-05 | 2016-06-23 | Inserm (Insititut National De La Sante Et De La Recherche Medicale) | Novel alternative splice transcripts for mhc class i related chain alpha (mica) and uses thereof |
WO2015004633A1 (en) | 2013-07-12 | 2015-01-15 | Neotope Biosciences Limited | Antibodies that recognize islet-amyloid polypeptide (iapp) |
US9850302B2 (en) | 2013-07-12 | 2017-12-26 | Prothena Biosciences Limited | Antibodies that recognize IAPP |
CN105683759B (zh) | 2013-08-07 | 2019-03-29 | 瑞颂医药公司 | 非典型溶血性尿毒综合征(aHUS)生物标志物蛋白 |
SG10201801063TA (en) | 2013-08-14 | 2018-04-27 | Novartis Ag | Methods of treating sporadic inclusion body myositis |
AR097306A1 (es) | 2013-08-20 | 2016-03-02 | Merck Sharp & Dohme | Modulación de la inmunidad tumoral |
BR112016012248A2 (pt) | 2013-11-28 | 2017-10-17 | B Creative Sweden Ab | método de tratamento de nefropatia |
EP2883883A1 (en) | 2013-12-16 | 2015-06-17 | Cardio3 Biosciences S.A. | Therapeutic targets and agents useful in treating ischemia reperfusion injury |
ES2851386T3 (es) | 2013-12-18 | 2021-09-06 | Csl Ltd | Método de tratamiento de las heridas |
WO2015090230A1 (en) | 2013-12-19 | 2015-06-25 | Novartis Ag | Human mesothelin chimeric antigen receptors and uses thereof |
US10023636B2 (en) | 2013-12-20 | 2018-07-17 | Intervet Inc. | Caninized murine antibodies to human PD-1 |
US10287354B2 (en) | 2013-12-20 | 2019-05-14 | Novartis Ag | Regulatable chimeric antigen receptor |
WO2015100409A2 (en) | 2013-12-26 | 2015-07-02 | Tufts University | Methods, compositions and kits for treating a subject using a recombinant neutralizing binding protein |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
EP3099707B1 (en) | 2014-01-30 | 2021-12-29 | Vib Vzw | Opioid receptor binding agents and uses thereof |
JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
WO2015122995A1 (en) | 2014-02-11 | 2015-08-20 | Visterra, Inc. | Antibody moleules to dengue virus and uses thereof |
JP2017506640A (ja) | 2014-02-14 | 2017-03-09 | セントローズ, エルエルシー | 細胞外標的化薬物共役体 |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
NZ711451A (en) | 2014-03-07 | 2016-05-27 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
LT3116909T (lt) | 2014-03-14 | 2020-02-10 | Novartis Ag | Antikūno molekulės prieš lag-3 ir jų panaudojimas |
US20170081411A1 (en) | 2014-03-15 | 2017-03-23 | Novartis Ag | Regulatable chimeric antigen receptor |
EP3119423B1 (en) | 2014-03-15 | 2022-12-14 | Novartis AG | Treatment of cancer using chimeric antigen receptor |
ES2762640T3 (es) | 2014-03-21 | 2020-05-25 | Regeneron Pharma | Proteínas VL de unión a antígeno que exhiben diferentes características de unión |
MX2016012274A (es) | 2014-03-21 | 2017-05-23 | Regeneron Pharma | Animales no humanos que producen proteinas de union de dominio simple. |
WO2015155694A1 (en) | 2014-04-08 | 2015-10-15 | Prothena Biosciences Limited | Blood-brain barrier shuttles containing antibodies recognizing alpha-synuclein |
TW201622746A (zh) | 2014-04-24 | 2016-07-01 | 諾華公司 | 改善或加速髖部骨折術後身體復原之方法 |
LT3134095T (lt) | 2014-04-25 | 2020-06-10 | Bluebird Bio, Inc. | Patobulinti adaptyviųjų ląstelių gydymo priemonės gamybos būdai |
DK3689899T3 (da) | 2014-04-25 | 2021-11-22 | 2Seventy Bio Inc | Kimære mnd-promotor-antigenreceptorer |
US9388239B2 (en) | 2014-05-01 | 2016-07-12 | Consejo Nacional De Investigation Cientifica | Anti-human VEGF antibodies with unusually strong binding affinity to human VEGF-A and cross reactivity to human VEGF-B |
CN113717280A (zh) | 2014-05-16 | 2021-11-30 | 埃博灵克斯股份有限公司 | 改进的免疫球蛋白可变结构域 |
MA40041B1 (fr) | 2014-05-28 | 2021-03-31 | Memorial Sloan Kettering Cancer Center | Anticorps anti-gitr et leurs procédés d'utilisation |
SG10201810723VA (en) | 2014-06-06 | 2018-12-28 | Bluebird Bio Inc | Improved t cell compositions |
NL2013007B1 (en) | 2014-06-16 | 2016-07-05 | Ablynx Nv | Methods of treating TTP with immunoglobulin single variable domains and uses thereof. |
NL2013661B1 (en) | 2014-10-21 | 2016-10-05 | Ablynx Nv | KV1.3 Binding immunoglobulins. |
EP3161001A2 (en) | 2014-06-25 | 2017-05-03 | Novartis AG | Antibodies specific for il-17a fused to hyaluronan binding peptide tags |
US20170290876A1 (en) | 2014-06-25 | 2017-10-12 | Novartis Ag | Compositions and methods for long acting proteins |
EP3160991A2 (en) | 2014-06-25 | 2017-05-03 | Novartis AG | Compositions and methods for long acting proteins |
WO2016014553A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
ES2805475T3 (es) | 2014-07-21 | 2021-02-12 | Novartis Ag | Tratamiento del cáncer utilizando un receptor antigénico quimérico de CD33 |
EP3172237A2 (en) | 2014-07-21 | 2017-05-31 | Novartis AG | Treatment of cancer using humanized anti-bcma chimeric antigen receptor |
EP3193915A1 (en) | 2014-07-21 | 2017-07-26 | Novartis AG | Combinations of low, immune enhancing. doses of mtor inhibitors and cars |
WO2016012363A1 (en) | 2014-07-22 | 2016-01-28 | Vib Vzw | Methods to select for agents that stabilize protein complexes |
AU2015292590B2 (en) | 2014-07-24 | 2020-01-16 | 2Seventy Bio, Inc. | BCMA chimeric antigen receptors |
US20180036442A1 (en) | 2014-07-29 | 2018-02-08 | Vrije Universiteit Brussel | Radio-labelled antibody fragments for use in the prognosis, diagnosis of cancer as well as for the prediction of cancer therapy response |
US9855348B2 (en) | 2014-07-29 | 2018-01-02 | Vrije Universiteit Brussel | Radio-labelled antibody fragments for use in the prevention and/or treatment of cancer |
EP3660042B1 (en) | 2014-07-31 | 2023-01-11 | Novartis AG | Subset-optimized chimeric antigen receptor-containing t-cells |
EP4122957A1 (en) | 2014-08-07 | 2023-01-25 | Novartis AG | Angiopoietin-like 4 antibodies and methods of use |
TW201613977A (en) | 2014-08-07 | 2016-04-16 | Novartis Ag | Angiopoetin-like 4 (ANGPTL4) antibodies and methods of use |
AU2015301460B2 (en) | 2014-08-14 | 2021-04-08 | Novartis Ag | Treatment of cancer using GFR alpha-4 chimeric antigen receptor |
JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
EA036311B1 (ru) | 2014-08-19 | 2020-10-26 | Мерк Шарп И Доум Корп. | Антитела против tigit |
EP3712171A1 (en) | 2014-08-19 | 2020-09-23 | Novartis AG | Treatment of cancer using a cd123 chimeric antigen receptor |
EP3659621A1 (en) | 2014-09-13 | 2020-06-03 | Novartis AG | Combination therapies for cancer |
MX2017003645A (es) | 2014-09-17 | 2017-05-30 | Novartis Ag | Direccion de celulas citotoxicas con receptores quimericos para inmunoterapia adoptiva. |
US20170209574A1 (en) | 2014-10-03 | 2017-07-27 | Novartis Ag | Combination therapies |
CA2962251A1 (en) | 2014-10-03 | 2016-04-07 | Ntercept, Llc | Compositions and methods for inhibiting the biological activity of soluble biomolecules |
MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
JP2017538779A (ja) | 2014-10-10 | 2017-12-28 | アブリンクス・エヌ・フェー | Rsv感染の治療方法 |
PT3204095T (pt) | 2014-10-10 | 2019-07-11 | Ablynx Nv | Dispositivo de inalação para usar na terapia com aerossóis de doenças respiratórias |
PE20171067A1 (es) | 2014-10-14 | 2017-07-24 | Novartis Ag | Moleculas de anticuerpo que se unen a pd-l1 y usos de las mismas |
WO2016061632A1 (en) | 2014-10-23 | 2016-04-28 | La Trobe University | Fn14-binding proteins and uses thereof |
CA2966548A1 (en) | 2014-11-05 | 2016-05-12 | Agrosavfe Nv | Transgenic plant comprising a polynucleotide encoding a variable domain of heavy-chain antibody |
WO2021173560A1 (en) | 2020-02-24 | 2021-09-02 | Immatics US, Inc. | Methods for expanding t cells for the treatment of cancer and related malignancies |
WO2016090034A2 (en) | 2014-12-03 | 2016-06-09 | Novartis Ag | Methods for b cell preconditioning in car therapy |
PL3800202T3 (pl) | 2014-12-11 | 2023-06-12 | Pierre Fabre Medicament | Przeciwciała przeciwko c10orf54 i ich zastosowania |
LT3628687T (lt) | 2014-12-12 | 2021-11-10 | 2Seventy Bio, Inc. | Chimeriniai bcma antigeno receptoriai |
WO2016094834A2 (en) | 2014-12-12 | 2016-06-16 | Alexion Pharmaceuticals, Inc. | A method for treating a complement mediated disorder caused by an infectious agent in a patient |
UY36449A (es) | 2014-12-19 | 2016-07-29 | Novartis Ag | Composiciones y métodos para anticuerpos dirigidos a bmp6 |
US20170340733A1 (en) | 2014-12-19 | 2017-11-30 | Novartis Ag | Combination therapies |
ES2772348T3 (es) | 2014-12-19 | 2020-07-07 | Ablynx Nv | Dímeros de Nanobody con uniones cisteína |
WO2016094962A1 (en) | 2014-12-19 | 2016-06-23 | Monash University | Il-21 antibodies |
JP7211703B2 (ja) | 2014-12-22 | 2023-01-24 | ザ ロックフェラー ユニバーシティー | 抗mertkアゴニスト抗体及びその使用 |
SG11201705293WA (en) | 2014-12-29 | 2017-07-28 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
JP6850255B2 (ja) | 2014-12-30 | 2021-03-31 | セルジーン コーポレイション | 抗−cd47抗体及びその使用 |
AU2015374385B2 (en) | 2014-12-31 | 2020-08-06 | Checkmate Pharmaceuticals, Inc. | Combination tumor immunotherapy |
WO2016112270A1 (en) | 2015-01-08 | 2016-07-14 | Biogen Ma Inc. | Lingo-1 antagonists and uses for treatment of demyelinating disorders |
GB201501004D0 (en) | 2015-01-21 | 2015-03-04 | Cancer Rec Tech Ltd | Inhibitors |
US11161907B2 (en) | 2015-02-02 | 2021-11-02 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
WO2016124558A1 (en) | 2015-02-03 | 2016-08-11 | Ventana Medical Systems, Inc. | Histochemical assay for evaluating expression of programmed death ligand 1 (pd-l1) |
CN114133450B (zh) | 2015-02-03 | 2023-09-22 | 国家健康与医学研究院 | 抗-Rho GTPase的构象单域抗体及其用途 |
ES2777534T3 (es) | 2015-02-13 | 2020-08-05 | Inserm - Institut National De La Santé Et De La Rech Médicale | Polipéptidos para la ingeniería de proteínas integrasas quiméricas y su uso en terapia génica |
EP3261665A1 (en) | 2015-02-24 | 2018-01-03 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Middle east respiratory syndrome coronavirus immunogens, antibodies, and their use |
WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
EP3061826A1 (en) | 2015-02-27 | 2016-08-31 | Novartis AG | Flavivirus replicons |
SI3265123T1 (sl) | 2015-03-03 | 2023-02-28 | Kymab Limited | Protitelesa, uporabe in postopki |
CA2979976A1 (en) | 2015-03-17 | 2016-09-22 | Memorial Sloan Kettering Cancer Center | Anti-muc16 antibodies and uses thereof |
MA41795A (fr) | 2015-03-18 | 2018-01-23 | Sarepta Therapeutics Inc | Exclusion d'un exon induite par des composés antisens dans la myostatine |
CA2979702A1 (en) | 2015-03-19 | 2016-09-22 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
TR201904903T4 (tr) | 2015-03-25 | 2019-05-21 | Alexion Pharma Inc | Alternatif tamamlama yolağının C3 ve C5 konvertazının proteaz aktivitesinin ölçülmesine yönelik bir yöntem. |
WO2016151558A1 (en) | 2015-03-25 | 2016-09-29 | Alexion Pharmaceuticals, Inc. | A method for measuring the protease activity of factor d of the alternative complement pathway |
EA035638B1 (ru) | 2015-03-31 | 2020-07-20 | ВиЭйчСКВЕАРД ЛИМИТЕД | Полипептиды |
JP6938383B2 (ja) | 2015-04-02 | 2021-09-22 | インターベット インターナショナル ベー. フェー. | イヌインターロイキン4受容体アルファに対する抗体 |
CA2981398A1 (en) | 2015-04-02 | 2016-10-06 | Ablynx N.V. | Bispecific cxcr4-cd4 polypeptides with potent anti-hiv activity |
EP3280795B1 (en) | 2015-04-07 | 2021-03-24 | Novartis AG | Combination of chimeric antigen receptor therapy and amino pyrimidine derivatives |
WO2016166110A1 (en) | 2015-04-13 | 2016-10-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treatment of haemorrhagic diseases |
US9778265B2 (en) | 2015-04-16 | 2017-10-03 | The United States Of America, As Represented By The Secretary Of The Navy | Charged peptide appendage to facilitate oriented protein covalent immobilization |
WO2016168601A1 (en) | 2015-04-17 | 2016-10-20 | Khalid Shah | Agents, systems and methods for treating cancer |
CN108473957A (zh) | 2015-04-17 | 2018-08-31 | 诺华股份有限公司 | 改善嵌合抗原受体表达细胞的功效和扩增的方法 |
EP3286211A1 (en) | 2015-04-23 | 2018-02-28 | Novartis AG | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
CN115109158A (zh) | 2015-05-07 | 2022-09-27 | 阿吉纳斯公司 | 抗ox40抗体及其使用方法 |
EP3736287A1 (en) | 2015-05-11 | 2020-11-11 | The Johns Hopkins University | Autoimmune antibodies for use in inhibiting cancer cell growth |
EP3294319B1 (en) | 2015-05-13 | 2024-04-24 | Ablynx NV | T cell recruiting polypeptides based on cd3 reactivity |
RS59376B1 (sr) | 2015-05-13 | 2019-11-29 | Ablynx Nv | Polipeptidi koji regrutuju t-ćelije na bazi tcr-alfa/beta reaktivnosti |
CA2986575A1 (en) | 2015-05-21 | 2016-11-24 | Harpoon Therapeutics, Inc. | Trispecific binding proteins and methods of use |
EP3302553A4 (en) | 2015-05-28 | 2019-03-06 | Bio-rad Laboratories, Inc. | AFFINITY LIGANDS AND ASSOCIATED METHODS |
MX2017015046A (es) | 2015-05-29 | 2018-05-17 | Agenus Inc | Anticuerpos anti-antigeno 4 del linfocito t citotoxico (ctla-4) y metodos para uso de los mismos. |
SG11201707815RA (en) | 2015-06-05 | 2017-12-28 | Novartis Ag | Antibodies targeting bone morphogenetic protein 9 (bmp9) and methods therefor |
US10696745B2 (en) | 2015-06-11 | 2020-06-30 | Wuxi Biologics (Shanghai) Co. Ltd. | Anti-PD-L1 antibodies |
WO2016207313A1 (en) | 2015-06-24 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for detecting protein-protein interactions |
JOP20200312A1 (ar) | 2015-06-26 | 2017-06-16 | Novartis Ag | الأجسام المضادة للعامل xi وطرق الاستخدام |
EP3325020B1 (en) | 2015-07-17 | 2022-01-12 | Vrije Universiteit Brussel | Radiolabelled antibody fragments for use in treating cancer |
AR105433A1 (es) | 2015-07-21 | 2017-10-04 | Novartis Ag | Métodos para mejorar la eficacia y expansión de las células inmunes |
ES2878188T3 (es) | 2015-07-29 | 2021-11-18 | Novartis Ag | Terapias de combinación que comprenden moléculas de anticuerpos contra LAG-3 |
WO2017019897A1 (en) | 2015-07-29 | 2017-02-02 | Novartis Ag | Combination therapies comprising antibody molecules to tim-3 |
EP3328399B1 (en) | 2015-07-31 | 2023-12-27 | Regents of the University of Minnesota | Modified cells and methods of therapy |
EP3328393B1 (en) | 2015-07-31 | 2023-12-20 | Centrose, Llc | Extracellular drug conjugates targeting cd20 |
KR20180035852A (ko) | 2015-08-03 | 2018-04-06 | 노파르티스 아게 | Fgf21-연관 장애를 치료하는 방법 |
WO2017020291A1 (en) | 2015-08-06 | 2017-02-09 | Wuxi Biologics (Shanghai) Co. Ltd. | Novel anti-pd-l1 antibodies |
CN107922479A (zh) | 2015-08-07 | 2018-04-17 | 默克专利股份公司 | 用于有效的位点特异性生物缀合的转谷氨酰胺标签 |
CN105384825B (zh) | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
MX2018001644A (es) | 2015-08-11 | 2018-11-09 | Wuxi Biologics Cayman Inc | Anticuerpos anti-pd-1 novedosos. |
KR20180037294A (ko) | 2015-08-31 | 2018-04-11 | 블루버드 바이오, 인코포레이티드. | 항-시알릴 Tn 키메라 항원 수용체 |
CN114605548A (zh) | 2015-09-01 | 2022-06-10 | 艾吉纳斯公司 | 抗-pd-1抗体及其使用方法 |
EP3344996A2 (en) | 2015-09-03 | 2018-07-11 | The Trustees Of The University Of Pennsylvania | Biomarkers predictive of cytokine release syndrome |
AU2016320748B2 (en) | 2015-09-09 | 2019-05-02 | Novartis Ag | Thymic stromal lymphopoietin (TSLP)-binding antibodies and methods of using the antibodies |
BR112018003326A2 (pt) | 2015-09-09 | 2018-09-18 | Novartis Ag | anticorpos de ligação de linfopoietina estromal tímica (tslp) e métodos de uso dos anticorpos |
UA126278C2 (uk) | 2015-09-21 | 2022-09-14 | Аптево Рісьорч Енд Девелопмент Ллс | Поліпептиди, які зв'язують cd3 |
US11203634B2 (en) | 2015-10-07 | 2021-12-21 | Alexion Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration in a patient comprising administering an anti-C5a antibody |
WO2017062835A2 (en) | 2015-10-09 | 2017-04-13 | Sarepta Therapeutics, Inc. | Compositions and methods for treating duchenne muscular dystrophy and related disorders |
CN105238759B (zh) * | 2015-10-14 | 2019-05-24 | 吉日木图 | 抗驼乳重链IgG3单克隆抗体、含有所述单克隆抗体的试纸及其应用 |
WO2017083515A2 (en) | 2015-11-10 | 2017-05-18 | Visterra, Inc. | Antibody molecule-drug conjugates and uses thereof |
NO2768984T3 (ja) | 2015-11-12 | 2018-06-09 | ||
US20180327499A1 (en) | 2015-11-13 | 2018-11-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti- nkg2d single domain antibodies and uses thereof |
JO3744B1 (ar) | 2015-11-18 | 2021-01-31 | Merck Sharp & Dohme | مواد ربط لـpd1 و/ أو lag3 |
CR20180279A (es) | 2015-11-18 | 2018-08-24 | Merck Sharp & Dohme | Enlazadores de ctla4 |
EP4285923A3 (en) | 2015-11-25 | 2024-03-06 | Visterra, Inc. | Antibody molecules to april and uses thereof |
KR20180080337A (ko) | 2015-11-27 | 2018-07-11 | 아블린쓰 엔.브이. | Cd40l을 억제하는 폴리펩티드 |
HUE051777T2 (hu) | 2015-12-04 | 2021-03-29 | Boehringer Ingelheim Int | Tumorsejtekben WNT-jelátvitelt antagonizáló biparatópos polipeptidek |
WO2017099712A1 (en) | 2015-12-07 | 2017-06-15 | Bluebird Bio, Inc. | Improved t cell compositions |
WO2017097889A1 (en) | 2015-12-10 | 2017-06-15 | Katholieke Universiteit Leuven | Anti adamts13 antibodies and their use for treatment or prevention of haemorrhagic disorders due to ventricular assist device |
BR112018012352A2 (pt) | 2015-12-16 | 2018-12-11 | Merck Sharp & Dohme Corp. | anticorpos anti-lag3 e fragmentos de ligação ao antígeno |
MX2018007423A (es) | 2015-12-17 | 2018-11-09 | Novartis Ag | Moleculas de anticuerpo que se unen a pd-1 y usos de las mismas. |
KR20180094977A (ko) | 2015-12-17 | 2018-08-24 | 노파르티스 아게 | c-Met 억제제와 PD-1에 대한 항체 분자의 조합물 및 그의 용도 |
CN109069623A (zh) | 2015-12-18 | 2018-12-21 | 诺华股份有限公司 | 靶向CD32b的抗体及其使用方法 |
US11091556B2 (en) | 2015-12-18 | 2021-08-17 | Intervet Inc. | Caninized human antibodies to human IL-4R alpha |
US11413340B2 (en) | 2015-12-22 | 2022-08-16 | Novartis Ag | Mesothelin chimeric antigen receptor (CAR) and antibody against PD-L1 inhibitor for combined use in anticancer therapy |
EP3397755A1 (en) | 2015-12-28 | 2018-11-07 | Novartis AG | Methods of making chimeric antigen receptor -expressing cells |
EP3411407B1 (en) | 2016-02-05 | 2024-04-03 | Orionis Biosciences BV | Bispecific signaling agents and uses thereof |
CU20180088A7 (es) | 2016-02-17 | 2019-05-03 | Novartis Ag | Anticuerpos anti tgfbeta 2 |
RU2018134771A (ru) | 2016-03-04 | 2020-04-06 | Новартис Аг | Клетки, экспрессирующие множество молекул химерных антигенных рецепторов (car), и их применение |
EP4276114A3 (en) | 2016-03-07 | 2024-02-21 | Vib Vzw | Cd20 binding single domain antibodies |
US10870701B2 (en) | 2016-03-15 | 2020-12-22 | Generon (Shanghai) Corporation Ltd. | Multispecific fab fusion proteins and use thereof |
WO2017158396A1 (en) | 2016-03-16 | 2017-09-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Cytidine deaminase inhibitors for the treatment of pancreatic cancer |
WO2017162604A1 (en) | 2016-03-21 | 2017-09-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosis and treatment of solar lentigo |
CN109153728A (zh) | 2016-03-21 | 2019-01-04 | 埃尔斯塔治疗公司 | 多特异性和多功能分子及其用途 |
US10822416B2 (en) | 2016-03-23 | 2020-11-03 | Mabspace Biosciences (Suzhou) Co., Ltd | Anti-PD-L1 antibodies |
WO2017165742A1 (en) | 2016-03-24 | 2017-09-28 | Millennium Pharmaceuticals, Inc. | Methods of treating gastrointestinal immune-related adverse events in anti-ctla4 anti-pd-1 combination treatments |
US11760803B2 (en) | 2016-03-24 | 2023-09-19 | Takeda Pharmaceutical Company Limited | Methods of treating gastrointestinal immune-related adverse events in immune oncology treatments |
JP7155009B2 (ja) | 2016-03-25 | 2022-10-18 | ビステラ, インコーポレイテッド | デングウイルスに対する抗体分子の製剤 |
WO2017176762A1 (en) | 2016-04-06 | 2017-10-12 | Nanotics, Llc | Particles comprising subparticles or nucleic acid scaffolds |
ES2866880T3 (es) | 2016-04-13 | 2021-10-20 | Inst Nat Sante Rech Med | Métodos y kits para la detección rápida del clon O25B-ST131 de Escherichia Coli |
ES2944607T3 (es) | 2016-04-15 | 2023-06-22 | Novartis Ag | Composiciones y métodos para la expresión selectiva de receptores quiméricos para el antígeno |
WO2017181098A2 (en) | 2016-04-15 | 2017-10-19 | Visterra, Inc. | Antibody molecules to zika virus and uses thereof |
WO2017182603A1 (en) | 2016-04-22 | 2017-10-26 | Université Libre de Bruxelles | A new biomarker expressed in pancreatic beta cells useful in imaging or targeting beta cells |
WO2017182605A1 (en) | 2016-04-22 | 2017-10-26 | Université Libre de Bruxelles | A new biomarker expressed in pancreatic beta cells useful in imaging or targeting beta cells |
JP7138567B2 (ja) | 2016-04-27 | 2022-09-16 | ノバルティス アーゲー | 成長分化因子15に対する抗体およびそれらの使用 |
US20190127447A1 (en) | 2016-05-02 | 2019-05-02 | Ablynx N.V. | Treatment of rsv infection |
DK3452507T3 (da) | 2016-05-02 | 2022-11-14 | Prothena Biosciences Ltd | Tau-immunoterapi |
CN109563141A (zh) | 2016-05-13 | 2019-04-02 | 奥里尼斯生物科学公司 | 对非细胞结构的治疗性靶向 |
DK3458478T3 (da) | 2016-05-18 | 2021-03-22 | Boehringer Ingelheim Int | Anti-pd-1- og anti-lag3-antistoffer til cancerbehandling |
SG11201810327XA (en) | 2016-05-20 | 2018-12-28 | Harpoon Therapeutics Inc | Single domain serum albumin binding protein |
CA3024683A1 (en) | 2016-05-20 | 2017-11-23 | Harpoon Therapeutics, Inc. | Single chain variable fragment cd3 binding proteins |
US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
WO2017202962A1 (en) | 2016-05-24 | 2017-11-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of non small cell lung cancer (nsclc) that coexists with chronic obstructive pulmonary disease (copd) |
BR112018074463A2 (pt) | 2016-05-27 | 2019-03-06 | Agenus Inc. | anticorpos anti-tim-3 e métodos de uso dos mesmos. |
WO2017213695A1 (en) | 2016-06-07 | 2017-12-14 | The Brigham And Women's Hospital, Inc. | Compositions and methods relating to t peripheral helper cells in autoantibody-associated conditions |
KR102492057B1 (ko) | 2016-06-15 | 2023-01-26 | 노파르티스 아게 | 골 형태형성 단백질 6(bmp6)의 억제제를 사용한 질병의 치료 방법 |
US11197902B2 (en) | 2016-06-24 | 2021-12-14 | Ig Biosciences Corporation | Prebiotic neutraceutical compositions and methods of treatment using the same |
WO2018007442A1 (en) | 2016-07-06 | 2018-01-11 | Ablynx N.V. | Treatment of il-6r related diseases |
KR20190039937A (ko) | 2016-07-08 | 2019-04-16 | 스태튼 바이오테크놀로지 비.브이. | 항-ApoC3 항체 및 이의 사용 방법 |
AU2017297404A1 (en) | 2016-07-13 | 2019-01-24 | Biogen Ma Inc. | Dosage regimens of LINGO-1 antagonists and uses for treatment of demyelinating disorders |
JP7219376B2 (ja) | 2016-07-15 | 2023-02-08 | ノバルティス アーゲー | キメラ抗原受容体をキナーゼ阻害薬と併用して使用したサイトカイン放出症候群の治療及び予防 |
WO2018014260A1 (en) | 2016-07-20 | 2018-01-25 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
KR20190034588A (ko) | 2016-07-28 | 2019-04-02 | 노파르티스 아게 | 키메라 항원 수용체 및 pd-1 억제제의 조합 요법 |
NL2017267B1 (en) | 2016-07-29 | 2018-02-01 | Aduro Biotech Holdings Europe B V | Anti-pd-1 antibodies |
CN110267677A (zh) | 2016-08-01 | 2019-09-20 | 诺华股份有限公司 | 使用与原m2巨噬细胞分子抑制剂组合的嵌合抗原受体治疗癌症 |
US11858980B2 (en) | 2016-08-02 | 2024-01-02 | Visterra, Inc. | Engineered polypeptides and uses thereof |
NL2017270B1 (en) | 2016-08-02 | 2018-02-09 | Aduro Biotech Holdings Europe B V | New anti-hCTLA-4 antibodies |
WO2018029182A1 (en) | 2016-08-08 | 2018-02-15 | Ablynx N.V. | Il-6r single variable domain antibodies for treatment of il-6r related diseases |
EP3512880A1 (en) | 2016-09-15 | 2019-07-24 | Ablynx NV | Immunoglobulin single variable domains directed against macrophage migration inhibitory factor |
KR20190049866A (ko) | 2016-09-20 | 2019-05-09 | 우시 바이올로직스 아일랜드 리미티드 | 신규한 항-pcsk9 항체 |
CA3033571A1 (en) | 2016-09-21 | 2018-03-29 | Nextcure, Inc. | Antibodies for siglec-15 and methods of use thereof |
WO2018053597A1 (en) | 2016-09-23 | 2018-03-29 | Csl Limited | Coagulation factor binding proteins and uses thereof |
WO2018057955A1 (en) | 2016-09-23 | 2018-03-29 | Elstar Therapeutics, Inc. | Multispecific antibody molecules comprising lambda and kappa light chains |
WO2018060453A1 (en) | 2016-09-30 | 2018-04-05 | Vhsquared Limited | Compositions |
EP3523331A1 (en) | 2016-10-07 | 2019-08-14 | Novartis AG | Chimeric antigen receptors for the treatment of cancer |
WO2018068201A1 (en) | 2016-10-11 | 2018-04-19 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against ctla-4 |
IL265800B2 (en) | 2016-10-11 | 2023-10-01 | Agenus Inc | Anti-LAG-3 antibodies and methods of using them |
JP7256741B2 (ja) | 2016-10-12 | 2023-04-12 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 感作レシピエントの腎移植における抗体関連型拒絶反応の予防における抗c5抗体の有効性 |
WO2018075664A1 (en) | 2016-10-18 | 2018-04-26 | Regents Of The University Of Minnesota | Tumor infiltrating lymphocytes and methods of therapy |
EP3529618B1 (en) | 2016-10-19 | 2020-12-02 | Alexion Pharmaceuticals, Inc. | A method of quantitating unbound c5 in a sample |
JP7173965B2 (ja) | 2016-10-19 | 2022-11-16 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 試料中の非結合C5aの定量化方法 |
MD3529262T2 (ro) | 2016-10-21 | 2022-01-31 | Inst Nat Sante Rech Med | Metode pentru promovarea răspunsului celulelor T |
US20200057046A1 (en) | 2016-10-27 | 2020-02-20 | Alexion Pharmaceuticals, Inc. | Assay for c5b-9 deposition in complement-associated disorders |
WO2018078083A1 (en) | 2016-10-28 | 2018-05-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New method for treating multiple myeloma |
AU2017348365A1 (en) | 2016-10-28 | 2019-05-23 | Astute Medical, Inc. | Use of antibodies to TIMP-2 for the improvement of renal function |
EP3534947A1 (en) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
KR102539159B1 (ko) | 2016-11-07 | 2023-06-02 | 주식회사 뉴라클사이언스 | 서열 유사성을 가진 항-패밀리 19, 멤버 a5 항체 및 그것의 사용 방법 |
US11840569B2 (en) | 2016-11-16 | 2023-12-12 | Ablynx N.V. | T cell recruiting polypeptides capable of binding CD123 and TCR alpha/beta |
KR102653324B1 (ko) | 2016-11-17 | 2024-04-01 | 2세븐티 바이오, 인코포레이티드 | TGFβ 신호 컨버터 |
WO2018091720A1 (en) | 2016-11-21 | 2018-05-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the prophylactic treatment of metastases |
BR112019010604A2 (pt) | 2016-11-23 | 2019-12-17 | Harpoon Therapeutics Inc | proteína de ligação ao antígeno da membrana próstata-específico |
CN110198737A (zh) | 2016-11-23 | 2019-09-03 | 哈普恩治疗公司 | 靶向psma的三特异性蛋白质及使用方法 |
WO2018099968A1 (en) | 2016-11-29 | 2018-06-07 | Ablynx N.V. | Treatment of infection by respiratory syncytial virus (rsv) |
US10759855B2 (en) | 2016-12-02 | 2020-09-01 | Rigel Pharmaceuticals, Inc. | Antigen binding molecules to TIGIT |
KR102603681B1 (ko) | 2016-12-07 | 2023-11-17 | 아게누스 인코포레이티드 | 항체 및 이의 사용방법 |
EP3551047A1 (en) | 2016-12-07 | 2019-10-16 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
LT3551660T (lt) | 2016-12-07 | 2023-12-27 | Agenus Inc. | Antikūnai prieš ctla-4 ir jų naudojimo būdai |
CN110072551B (zh) | 2016-12-14 | 2023-05-23 | 比奥拉治疗股份有限公司 | 使用利用可摄入装置释放的il-12/il-23抑制剂治疗胃肠道疾病 |
US20200253506A1 (en) | 2016-12-14 | 2020-08-13 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
WO2018112237A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an il-6r inhibitor |
AU2017378406A1 (en) | 2016-12-14 | 2019-06-13 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with an immunosuppressant |
EP3554345A1 (en) | 2016-12-14 | 2019-10-23 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a smad7 inhibitor |
EP3554541B1 (en) | 2016-12-14 | 2023-06-07 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
US11426566B2 (en) | 2016-12-14 | 2022-08-30 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with a TLR modulator |
WO2018112256A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an il-1 inhibitor |
CN110430801A (zh) | 2016-12-14 | 2019-11-08 | 普罗根尼蒂公司 | 使用tnf抑制剂治疗胃肠道疾病 |
CA3045666A1 (en) | 2016-12-14 | 2018-06-21 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a jak inhibitor and devices |
EP3360898A1 (en) | 2017-02-14 | 2018-08-15 | Boehringer Ingelheim International GmbH | Bispecific anti-tnf-related apoptosis-inducing ligand receptor 2 and anti-cadherin 17 binding molecules for the treatment of cancer |
AU2017383232A1 (en) | 2016-12-23 | 2019-06-27 | Novartis Ag | Factor XI antibodies and methods of use |
RU2019123063A (ru) | 2016-12-23 | 2021-01-26 | Вистерра, Инк. | Связывающие полипептиды и способы их получения |
EP3565560A4 (en) | 2017-01-09 | 2021-01-13 | Bioxcel Therapeutics, Inc. | PREDICTIVE AND DIAGNOSTIC PROCEDURES FOR PROSTATE CANCER |
CN110431150A (zh) | 2017-01-18 | 2019-11-08 | 威特拉公司 | 抗体分子-药物偶联物及其用途 |
AU2018210420A1 (en) | 2017-01-19 | 2019-08-08 | Omniab, Inc. | Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci |
US11535662B2 (en) | 2017-01-26 | 2022-12-27 | Novartis Ag | CD28 compositions and methods for chimeric antigen receptor therapy |
WO2018141753A1 (en) | 2017-01-31 | 2018-08-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for treating squamous cell carcinomas |
KR102642385B1 (ko) | 2017-02-06 | 2024-03-04 | 오리오니스 바이오사이언시스 엔브이 | 표적화된 키메라 단백질 및 이의 용도 |
TWI786087B (zh) | 2017-02-08 | 2022-12-11 | 瑞士商諾華公司 | Fgf21模擬抗體及其用途 |
WO2018151820A1 (en) | 2017-02-16 | 2018-08-23 | Elstar Therapeutics, Inc. | Multifunctional molecules comprising a trimeric ligand and uses thereof |
EP3589647A1 (en) | 2017-02-28 | 2020-01-08 | Novartis AG | Shp inhibitor compositions and uses for chimeric antigen receptor therapy |
EP3589662A4 (en) | 2017-02-28 | 2020-12-30 | Harpoon Therapeutics, Inc. | INDUCTIBLE MONOVALENT ANTIGBINDING PROTEIN |
JP7186401B2 (ja) | 2017-02-28 | 2022-12-09 | フエー・イー・ベー・フエー・ゼツト・ウエー | タンパク質の経口送達のための手段及び方法 |
US20200064341A1 (en) | 2017-03-14 | 2020-02-27 | Nanotag Biotechnologies Gmbh | Target detection using a monovalent antibody |
EP4095161A1 (en) | 2017-03-15 | 2022-11-30 | Tsinghua University | Novel anti-trkb antibodies |
WO2018167283A1 (en) | 2017-03-17 | 2018-09-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma associated neural remodeling |
CN110461359A (zh) | 2017-03-24 | 2019-11-15 | 诺华股份有限公司 | 用于预防和治疗心脏病的方法 |
EP3601351A1 (en) | 2017-03-27 | 2020-02-05 | Celgene Corporation | Methods and compositions for reduction of immunogenicity |
US20200094031A1 (en) | 2017-03-30 | 2020-03-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a chst15 inhibitor |
WO2018183932A1 (en) | 2017-03-30 | 2018-10-04 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a il-13 inhibitor |
CA3054632A1 (en) | 2017-03-30 | 2018-10-04 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device |
US11596670B2 (en) | 2017-03-30 | 2023-03-07 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with IL-10 or an IL-10 agonist |
WO2018183941A2 (en) | 2017-03-30 | 2018-10-04 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with live biotherapeutics |
KR20200020662A (ko) | 2017-04-03 | 2020-02-26 | 온콜로지, 인크. | 면역-종양학 제제와 함께 ps-표적화 항체를 사용하여 암을 치료하는 방법 |
WO2018185516A1 (en) | 2017-04-05 | 2018-10-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cardiovascular toxicity induced by anti-cancer therapy |
EP3610264A1 (en) | 2017-04-13 | 2020-02-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma |
KR102629972B1 (ko) | 2017-04-13 | 2024-01-29 | 아게누스 인코포레이티드 | 항-cd137 항체 및 이의 사용 방법 |
WO2018189403A1 (en) | 2017-04-14 | 2018-10-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of cancer |
EP3612648A1 (en) | 2017-04-18 | 2020-02-26 | Université Libre de Bruxelles | Biomarkers and targets for proliferative diseases |
JP2020517605A (ja) | 2017-04-19 | 2020-06-18 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 腎臓移植の感作されたレシピエントにおける抗体媒介性拒絶の予防における抗c5抗体の有効性 |
EP3612563A1 (en) | 2017-04-19 | 2020-02-26 | Elstar Therapeutics, Inc. | Multispecific molecules and uses thereof |
EP3612560A1 (en) | 2017-04-21 | 2020-02-26 | Staten Biotechnology B.V. | Anti-apoc3 antibodies and methods of use thereof |
US20200385472A1 (en) | 2017-04-28 | 2020-12-10 | Elstar Therapeutics, Inc. | Multispecific molecules comprising a non-immunoglobulin heterodimerization domain and uses thereof |
EP3615068A1 (en) | 2017-04-28 | 2020-03-04 | Novartis AG | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
US20200055948A1 (en) | 2017-04-28 | 2020-02-20 | Novartis Ag | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
CA3062061A1 (en) | 2017-05-01 | 2018-11-08 | Agenus Inc. | Anti-tigit antibodies and methods of use thereof |
US11891451B2 (en) | 2017-05-11 | 2024-02-06 | Vib Vzw | Glycosylation of variable immunoglobulin domains |
EP3621648A4 (en) | 2017-05-12 | 2021-01-20 | Harpoon Therapeutics, Inc. | TRISPECIFIC PROTEINS MSLN AND METHOD OF USE |
JP7090347B2 (ja) | 2017-05-12 | 2022-06-24 | ハープーン セラピューティクス,インク. | メソテリン結合タンパク質 |
JP7169298B2 (ja) | 2017-05-12 | 2022-11-10 | オーガスタ ユニバーシティ リサーチ インスティテュート,インコーポレーテッド | ヒトアルファフェトタンパク質特異的t細胞受容体およびその使用 |
JOP20190256A1 (ar) | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | فيروسات داء نيوكاسل واستخداماتها |
US11225514B2 (en) | 2017-05-30 | 2022-01-18 | The Regents Of The University Of California | Nanobodies against cystic fibrosis transmembrane conductance regulator (CFTR) inhibitory factor (Cif) |
KR20200011933A (ko) | 2017-05-31 | 2020-02-04 | 베링거 인겔하임 인터내셔날 게엠베하 | 종양 세포에서 wnt 신호 전달을 길항하는 폴리펩티드 |
WO2018222901A1 (en) | 2017-05-31 | 2018-12-06 | Elstar Therapeutics, Inc. | Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof |
CN111032695A (zh) | 2017-06-02 | 2020-04-17 | 默克专利股份有限公司 | 结合adamts的免疫球蛋白 |
TWI826376B (zh) | 2017-06-02 | 2023-12-21 | 德商麥克專利有限公司 | 與adamts5、mmp13及聚集蛋白聚醣結合的多肽 |
AR112069A1 (es) | 2017-06-02 | 2019-09-18 | Ablynx Nv | Inmunoglobulinas que fijan aggrecan |
KR20200013231A (ko) | 2017-06-02 | 2020-02-06 | 베링거 인겔하임 인터내셔날 게엠베하 | 항암 조합 요법 |
BR112019025097A2 (pt) | 2017-06-02 | 2020-07-28 | Merck Patent Gmbh | imunoglobulinas de ligação a mmp13 |
EP3415010A1 (en) | 2017-06-13 | 2018-12-19 | Agrosavfe Nv | Insect-controlling polypeptides and methods |
GB201709379D0 (en) | 2017-06-13 | 2017-07-26 | Univ Leuven Kath | Humanised ADAMTS13 binding antibodies |
WO2018229715A1 (en) | 2017-06-16 | 2018-12-20 | Novartis Ag | Compositions comprising anti-cd32b antibodies and methods of use thereof |
US20190062428A1 (en) | 2017-06-19 | 2019-02-28 | Surface Oncology, Inc. | Combination of anti-cd47 antibodies and cell death-inducing agents, and uses thereof |
PE20200717A1 (es) | 2017-06-22 | 2020-07-21 | Novartis Ag | Moleculas de anticuerpo que se unen a cd73 y usos de las mismas |
EP3642240A1 (en) | 2017-06-22 | 2020-04-29 | Novartis AG | Antibody molecules to cd73 and uses thereof |
WO2019000223A1 (en) | 2017-06-27 | 2019-01-03 | Nanjing Legend Biotech Co., Ltd. | ENABLERS OF IMMUNE EFFECTOR CELLS OF CHIMERIC ANTIBODIES AND METHODS OF USE THEREOF |
CA3066747A1 (en) | 2017-06-27 | 2019-01-03 | Novartis Ag | Dosage regimens for anti-tim-3 antibodies and uses thereof |
WO2019005756A1 (en) | 2017-06-28 | 2019-01-03 | The Rockefeller University | CONJUGATES AGONIST ANTIBODY ANTI-MERTK-MEDICINE |
TW201906865A (zh) | 2017-06-28 | 2019-02-16 | 瑞士商諾華公司 | 預防及治療尿失禁之方法 |
WO2019006418A2 (en) | 2017-06-30 | 2019-01-03 | Intima Bioscience, Inc. | ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY |
TWI820031B (zh) | 2017-07-11 | 2023-11-01 | 美商坎伯斯治療有限責任公司 | 結合人類cd137之促效劑抗體及其用途 |
JP2020532285A (ja) | 2017-07-11 | 2020-11-12 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 補体成分c5または血清アルブミンと結合するポリペプチドおよびその融合タンパク質 |
WO2019012030A1 (en) | 2017-07-13 | 2019-01-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | DHODH INHIBITOR AND CHK1 INHIBITOR FOR THE TREATMENT OF CANCER |
KR102625929B1 (ko) | 2017-07-19 | 2024-01-16 | 브이아이비 브이지더블유 | 혈청 알부민 결합제 |
EP3431496A1 (en) | 2017-07-19 | 2019-01-23 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Anti- isoasp7 amyloid beta antibodies and uses thereof |
JP2020527572A (ja) | 2017-07-20 | 2020-09-10 | ノバルティス アーゲー | 抗lag−3抗体の投薬量レジメンおよびその使用 |
WO2019016784A1 (en) | 2017-07-21 | 2019-01-24 | Universidade De Coimbra | ANTI-NUCLEOLIN ANTIBODIES |
US11174322B2 (en) | 2017-07-24 | 2021-11-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antibodies and peptides to treat HCMV related diseases |
AU2018306612C1 (en) | 2017-07-27 | 2023-11-09 | Alexion Pharmaceuticals, Inc. | High concentration anti-C5 antibody formulations |
WO2019028172A1 (en) | 2017-08-01 | 2019-02-07 | Compass Therapeutics Llc | FILTRATION AND CHROMATOGRAPHY CAPSULES AND METHODS OF USE |
US20200306516A1 (en) | 2017-08-14 | 2020-10-01 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with glatiramer or a pharmaceutically acceptable salt thereof |
WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
WO2019036605A2 (en) | 2017-08-17 | 2019-02-21 | Massachusetts Institute Of Technology | MULTIPLE SPECIFICITY BINDING AGENTS OF CXC CHEMOKINES AND USES THEREOF |
WO2019051164A1 (en) | 2017-09-07 | 2019-03-14 | Augusta University Research Institute, Inc. | ANTIBODIES AGAINST PROTEIN 1 OF PROGRAMMED CELL DEATH |
CN111655340A (zh) | 2017-09-20 | 2020-09-11 | 国家医疗保健研究所 | 用于调节自噬的方法和药物组合物 |
EP3461841B1 (en) | 2017-10-02 | 2019-09-11 | Certest Biotec, S.L. | Anti-dps antibodies and test devices for the detection of bacteria of the genus campylobacter |
SG11202002248TA (en) | 2017-10-02 | 2020-04-29 | Visterra Inc | Antibody molecules to cd138 and uses thereof |
US11230601B2 (en) | 2017-10-10 | 2022-01-25 | Tilos Therapeutics, Inc. | Methods of using anti-lap antibodies |
CN111511766A (zh) | 2017-10-13 | 2020-08-07 | Ose免疫疗法 | 修饰的抗SIRPa抗体及其应用 |
PE20201183A1 (es) | 2017-10-13 | 2020-11-03 | Harpoon Therapeutics Inc | Proteinas trispecificas y metodos de uso |
KR102429747B1 (ko) | 2017-10-13 | 2022-08-05 | 하푼 테라퓨틱스, 인크. | B 세포 성숙화 항원 결합 단백질 |
WO2019075519A1 (en) | 2017-10-18 | 2019-04-25 | Csl Limited | HUMAN SERUM ALBUMIN VARIANTS AND USES THEREOF |
MX2020004074A (es) | 2017-10-19 | 2020-10-16 | Debiopharm Int Sa | Producto de combinacion para el tratamiento de cancer. |
CA3078270A1 (en) | 2017-10-25 | 2019-05-02 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
EP3700933A1 (en) | 2017-10-25 | 2020-09-02 | Novartis AG | Antibodies targeting cd32b and methods of use thereof |
KR20200091400A (ko) | 2017-10-31 | 2020-07-30 | 브이아이비 브이지더블유 | 신규한 항원-결합 키메라 단백질 및 이의 방법 및 용도 |
US11718679B2 (en) | 2017-10-31 | 2023-08-08 | Compass Therapeutics Llc | CD137 antibodies and PD-1 antagonists and uses thereof |
US20210179709A1 (en) | 2017-10-31 | 2021-06-17 | Novartis Ag | Anti-car compositions and methods |
AU2018361957B2 (en) | 2017-10-31 | 2023-05-25 | Staten Biotechnology B.V. | Anti-ApoC3 antibodies and methods of use thereof |
EP3703751A2 (en) | 2017-11-03 | 2020-09-09 | Rubius Therapeutics, Inc. | Compositions and methods related to therapeutic cell systems for tumor growth inhibition |
CA3081602A1 (en) | 2017-11-16 | 2019-05-23 | Novartis Ag | Combination therapies |
US11851497B2 (en) | 2017-11-20 | 2023-12-26 | Compass Therapeutics Llc | CD137 antibodies and tumor antigen-targeting antibodies and uses thereof |
DK3717011T3 (da) | 2017-11-29 | 2023-01-09 | Csl Ltd | Fremgangsmåde til behandling eller forebyggelse af iskæmi-reperfusionsskade |
WO2019106126A1 (en) | 2017-12-01 | 2019-06-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Mdm2 modulators for the diagnosis and treatment of liposarcoma |
US11639496B2 (en) | 2017-12-05 | 2023-05-02 | Celyad S.A. | Reducing fratricide of immune cells expressing NKG2D-based receptors |
WO2019110693A1 (en) | 2017-12-05 | 2019-06-13 | Celyad S.A. | Compositions and methods for improving persistence of cells for adoptive transfer |
EP3720881A1 (en) | 2017-12-08 | 2020-10-14 | Elstar Therapeutics, Inc. | Multispecific molecules and uses thereof |
WO2019121872A1 (en) | 2017-12-20 | 2019-06-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of liver cancer |
WO2019129137A1 (zh) | 2017-12-27 | 2019-07-04 | 信达生物制药(苏州)有限公司 | 抗lag-3抗体及其用途 |
WO2019129136A1 (zh) | 2017-12-27 | 2019-07-04 | 信达生物制药(苏州)有限公司 | 抗pd-l1抗体及其用途 |
CN109970857B (zh) | 2017-12-27 | 2022-09-30 | 信达生物制药(苏州)有限公司 | 抗pd-l1抗体及其用途 |
CN109970856B (zh) | 2017-12-27 | 2022-08-23 | 信达生物制药(苏州)有限公司 | 抗lag-3抗体及其用途 |
WO2019129054A1 (zh) | 2017-12-27 | 2019-07-04 | 信达生物制药(苏州)有限公司 | 三链抗体、其制备方法及其用途 |
WO2019129221A1 (en) | 2017-12-28 | 2019-07-04 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against tigit |
CN108218990B (zh) | 2017-12-29 | 2021-03-02 | 南京优迈生物科技有限公司 | 分离的抗体或其抗原结合片段及其在肿瘤治疗中的应用 |
US20190330591A1 (en) | 2018-01-10 | 2019-10-31 | Rubius Therapeutics, Inc. | Amplifiable rnas for therapeutic cell systems |
US11713353B2 (en) | 2018-01-15 | 2023-08-01 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against PD-1 |
WO2019147478A2 (en) | 2018-01-18 | 2019-08-01 | California Institute Of Technology | Programmable protein circuits in living cells |
BR112020014929A2 (pt) | 2018-01-23 | 2020-12-08 | Nextcure, Inc. | Composição farmacêutica, métodos para aumentar, para reduzir, para intensificar ou induzir uma resposta imune em um indivíduo, molécula, anticorpo monoclonal ou fragmento de ligação ao antígeno do mesmo, ácido nucleico, anticorpo monoclonal anti-b7h4 ou fragmento de ligação ao antígeno do mesmo, anticorpo anti-b7h4 ou fragmento de ligação ao antígeno do mesmo, cadeias leve e pesada de anticorpo anti-b7h4, e, cadeias leve e pesada de anticorpo |
JP2021510594A (ja) | 2018-01-25 | 2021-04-30 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 臓器の虚血再灌流傷害を予防する方法における使用のためのil−33のアンタゴニスト |
EP3746116A1 (en) | 2018-01-31 | 2020-12-09 | Novartis AG | Combination therapy using a chimeric antigen receptor |
EP3749690A1 (en) | 2018-02-05 | 2020-12-16 | Stichting VU | Inverse agonistic anti-us28 antibodies |
WO2019152979A1 (en) | 2018-02-05 | 2019-08-08 | Orionis Biosciences, Inc. | Fibroblast binding agents and use thereof |
CA3089211A1 (en) | 2018-02-06 | 2019-08-15 | Ablynx Nv | Methods of treating initial episode of ttp with immunoglobulin single variable domains |
US11802303B2 (en) | 2018-02-07 | 2023-10-31 | Georgia Tech Research Corporation | Methods for multiplexed cell isolation using DNA gates |
WO2019155041A1 (en) | 2018-02-12 | 2019-08-15 | Vib Vzw | Gβγ COMPLEX ANTIBODIES AND USES THEREOF |
WO2019156566A1 (en) | 2018-02-12 | 2019-08-15 | Umc Utrecht Holding B.V. | Bispecific molecules comprising gamma-delta tcr and t-cell or nk cell binding domain |
WO2019158512A1 (en) | 2018-02-13 | 2019-08-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the prognosis and the treatment of glioblastoma |
US20210002373A1 (en) | 2018-03-01 | 2021-01-07 | Nextcure, Inc. | KLRG1 Binding Compositions and Methods of Use Thereof |
JP2021514649A (ja) | 2018-03-01 | 2021-06-17 | ブレイエ・ユニバージテイト・ブリュッセルVrije Universiteit Brussel | ヒトpd−l1結合免疫グロブリン |
NL2020520B1 (en) | 2018-03-02 | 2019-09-12 | Labo Bio Medical Invest B V | Multispecific binding molecules for the prevention, treatment and diagnosis of neurodegenerative disorders |
MX2020009507A (es) | 2018-03-13 | 2020-10-22 | Smivet B V | Anticuerpos de dominio individual que se unen a la neurotoxina del tetanos. |
US20210009711A1 (en) | 2018-03-14 | 2021-01-14 | Elstar Therapeutics, Inc. | Multifunctional molecules and uses thereof |
MX2021015518A (es) | 2018-03-14 | 2022-07-21 | Surface Oncology Inc | Anticuerpos que se unen a cd39 y sus usos. |
WO2019178362A1 (en) | 2018-03-14 | 2019-09-19 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
US11661452B2 (en) | 2018-03-20 | 2023-05-30 | WuXi Biologics Ireland Limited | Anti-lag-3 antibody polypeptide |
US11332524B2 (en) | 2018-03-22 | 2022-05-17 | Surface Oncology, Inc. | Anti-IL-27 antibodies and uses thereof |
EP3768701B1 (en) | 2018-03-23 | 2023-08-02 | Université Libre de Bruxelles | Wnt signaling agonist molecules |
WO2019184909A1 (zh) | 2018-03-27 | 2019-10-03 | 信达生物制药(苏州)有限公司 | 新型抗体分子、其制备方法及其用途 |
JP2021519093A (ja) | 2018-03-27 | 2021-08-10 | ユーエムシー ユトレヒト ホールディング ビー.ブイ. | 微小血管血栓症の処置のための標的化血栓溶解 |
WO2019185683A1 (en) | 2018-03-28 | 2019-10-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cancer |
WO2019193375A1 (en) | 2018-04-04 | 2019-10-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of fzd7 inhibitors for the treatment of retinal neovascularization |
WO2019200357A1 (en) | 2018-04-12 | 2019-10-17 | Surface Oncology, Inc. | Biomarker for cd47 targeting therapeutics and uses therefor |
US20210147547A1 (en) | 2018-04-13 | 2021-05-20 | Novartis Ag | Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof |
WO2019197683A1 (en) | 2018-04-13 | 2019-10-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting outcome and treatment of patients suffering from prostate cancer or breast cancer |
WO2019207030A1 (en) | 2018-04-26 | 2019-10-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting a response with an immune checkpoint inhibitor in a patient suffering from a lung cancer |
EP3784351A1 (en) | 2018-04-27 | 2021-03-03 | Novartis AG | Car t cell therapies with enhanced efficacy |
WO2019211370A1 (en) | 2018-05-03 | 2019-11-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cancer |
WO2019211369A1 (en) | 2018-05-03 | 2019-11-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cancer |
WO2019217913A1 (en) | 2018-05-10 | 2019-11-14 | Sensei Biotherapeutics, Inc. | Aspartate beta-hydroxylase chimeric antigen receptors and uses thereof |
AU2019271138A1 (en) | 2018-05-14 | 2021-01-07 | Harpoon Therapeutics, Inc. | Binding moiety for conditional activation of immunoglobulin molecules |
EP3569618A1 (en) | 2018-05-19 | 2019-11-20 | Boehringer Ingelheim International GmbH | Antagonizing cd73 antibody |
WO2019226658A1 (en) | 2018-05-21 | 2019-11-28 | Compass Therapeutics Llc | Multispecific antigen-binding compositions and methods of use |
CN112384534A (zh) | 2018-05-21 | 2021-02-19 | 指南针制药有限责任公司 | 用于增强nk细胞对靶细胞的杀死的组合物和方法 |
WO2019226050A2 (en) | 2018-05-24 | 2019-11-28 | Wageningen Universiteit | Novel viral anti-infective reagents |
AR126019A1 (es) | 2018-05-30 | 2023-09-06 | Novartis Ag | Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación |
WO2019232244A2 (en) | 2018-05-31 | 2019-12-05 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
TW202016136A (zh) | 2018-06-01 | 2020-05-01 | 瑞士商諾華公司 | 針對bcma之結合分子及其用途 |
WO2019234099A1 (en) | 2018-06-06 | 2019-12-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing, predicting the outcome and treating a patient suffering from heart failure with preserved ejection fraction |
WO2019234221A1 (en) | 2018-06-08 | 2019-12-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for stratification and treatment of a patient suffering from chronic lymphocytic leukemia |
TW202016151A (zh) | 2018-06-09 | 2020-05-01 | 德商百靈佳殷格翰國際股份有限公司 | 針對癌症治療之多特異性結合蛋白 |
WO2019241315A1 (en) | 2018-06-12 | 2019-12-19 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
MX2020013443A (es) | 2018-06-13 | 2021-02-26 | Novartis Ag | Receptores de antigeno quimerico de bcma y usos de los mismos. |
BR112020025439A2 (pt) | 2018-06-14 | 2021-03-16 | Bluebird Bio, Inc. | Receptores de antígenos quiméricos cd79a |
US20210238268A1 (en) | 2018-06-19 | 2021-08-05 | Atarga, Llc | Antibody molecules to complement component 5 and uses thereof |
US20230041197A1 (en) | 2018-06-20 | 2023-02-09 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
US20230009902A1 (en) | 2018-06-20 | 2023-01-12 | Progenity, Inc. | Treatment of a disease or condition in a tissue orginating from the endoderm |
EP3841124A4 (en) | 2018-06-29 | 2022-03-23 | ApitBio, Inc. | ANTI-L1CAM ANTIBODIES AND THEIR USES |
EP3816186A4 (en) | 2018-06-29 | 2022-04-06 | Suzhou Smartnuclide Biopharmaceutical Co., Ltd. | PD-L1 BINDING POLYPEPTIDE AND USE |
CA3105448A1 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
WO2020014333A1 (en) | 2018-07-11 | 2020-01-16 | Celgene Corporation | Uses of anti-bcma chimeric antigen receptors |
CN112673092B (zh) | 2018-07-11 | 2024-03-29 | 阿克蒂姆治疗有限公司 | 工程化的免疫刺激性细菌菌株及其用途 |
WO2020016160A1 (en) | 2018-07-16 | 2020-01-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method to treat neurological diseases |
US20210290633A1 (en) | 2018-07-19 | 2021-09-23 | INSERM (Insstitut National de la Santé et de la Recherche Médicale) | Combination for treating cancer |
JP2021531007A (ja) | 2018-07-20 | 2021-11-18 | ピエール、ファーブル、メディカマン | Vistaに対する受容体 |
WO2020021465A1 (en) | 2018-07-25 | 2020-01-30 | Advanced Accelerator Applications (Italy) S.R.L. | Method of treatment of neuroendocrine tumors |
ES2738926A1 (es) | 2018-07-26 | 2020-01-27 | Univ Zaragoza | Granulisina, metodo de obtencion y usos |
WO2020028909A1 (en) | 2018-08-03 | 2020-02-06 | Brown University | Oral formulations with increased uptake |
EP3833443A1 (en) | 2018-08-09 | 2021-06-16 | Compass Therapeutics LLC | Antigen binding agents that bind cd277 and uses thereof |
US20210309746A1 (en) | 2018-08-09 | 2021-10-07 | Compass Therapeutics Llc | Antibodies that bind cd277 and uses thereof |
WO2020033925A2 (en) | 2018-08-09 | 2020-02-13 | Compass Therapeutics Llc | Antibodies that bind cd277 and uses thereof |
US11453893B2 (en) | 2018-08-30 | 2022-09-27 | California Institute Of Technology | RNA-based delivery systems with levels of control |
SG11202101825QA (en) | 2018-08-31 | 2021-03-30 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
WO2020047449A2 (en) | 2018-08-31 | 2020-03-05 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
US11542305B2 (en) | 2018-08-31 | 2023-01-03 | California Institute Of Technology | Synthetic protein circuits detecting signal transducer activity |
CN112585169A (zh) | 2018-09-04 | 2021-03-30 | 南京优迈生物科技有限公司 | 融合蛋白及其在制备用于治疗肿瘤和/或病毒感染的药物中的应用 |
GB201814451D0 (en) | 2018-09-05 | 2018-10-17 | Valerie Nicholas Carl Kristoffer | Methods |
GB2576914A (en) | 2018-09-06 | 2020-03-11 | Kymab Ltd | Antigen-binding molecules comprising unpaired variable domains produced in mammals |
CN113195516A (zh) * | 2018-09-11 | 2021-07-30 | 纳诺泰克生物技术公司 | 由特异性结合物识别的表位标签 |
EP3856772A1 (en) | 2018-09-25 | 2021-08-04 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Use of antagonists of th17 cytokines for the treatment of bronchial remodeling in patients suffering from allergic asthma |
JP7425049B2 (ja) | 2018-09-25 | 2024-01-30 | ハープーン セラピューティクス,インク. | Dll3結合タンパク質および使用方法 |
JP7465272B2 (ja) | 2018-09-27 | 2024-04-10 | マレンゴ・セラピューティクス,インコーポレーテッド | Csf1r/ccr2多特異性抗体 |
CA3113618A1 (en) | 2018-09-28 | 2020-04-02 | Massachusetts Institute Of Technology | Collagen-localized immunomodulatory molecules and methods thereof |
WO2020070062A1 (en) | 2018-10-01 | 2020-04-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of tim-3 inhibitors for the treatment of exacerbations in patients suffering from severe asthma |
AU2019352017A1 (en) | 2018-10-03 | 2021-05-06 | Staten Biotechnology B.V. | Antibodies specific for human and cynomolgus ApoC3 and methods of use thereof |
EP3860653A1 (en) | 2018-10-05 | 2021-08-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and systems for controlling the agonistic properties of antibody variable domains by light |
TW202035445A (zh) | 2018-10-10 | 2020-10-01 | 美商帝洛斯療法股份有限公司 | 抗lap抗體變異體及其用途 |
UY38407A (es) | 2018-10-15 | 2020-05-29 | Novartis Ag | Anticuerpos estabilizadores de trem2 |
WO2020080941A1 (en) | 2018-10-16 | 2020-04-23 | Umc Utrecht Holding B.V. | Anti- low-density lipoprotein receptor-related protein 5/6 antibodies |
WO2020086742A1 (en) | 2018-10-24 | 2020-04-30 | Obsidian Therapeutics, Inc. | Er tunable protein regulation |
US20220000893A1 (en) | 2018-10-31 | 2022-01-06 | |Nserm (Institut National De La Santé Et De La Recherche Médicale) | Method for treating t-helper type 2 mediated disease |
CA3119161A1 (en) | 2018-11-13 | 2020-05-22 | Compass Therapeutics Llc | Multispecific binding constructs against checkpoint molecules and uses thereof |
GB201818477D0 (en) | 2018-11-13 | 2018-12-26 | Emstopa Ltd | Tissue plasminogen activator antibodies and method of use thereof |
US20220026445A1 (en) | 2018-12-07 | 2022-01-27 | Georgia Tech Research Corporation | Antibodies that bind to natively folded myocilin |
WO2020120644A1 (en) | 2018-12-13 | 2020-06-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New anti tau svqivykpv epitope single domain antibody |
JP2022513255A (ja) | 2018-12-20 | 2022-02-07 | ノバルティス アーゲー | HDM2-p53相互作用阻害剤とBCL2阻害剤との組み合わせ及び癌を処置するためのその使用 |
WO2020130838A2 (en) | 2018-12-21 | 2020-06-25 | Qvq Holding B.V. | Antibodies for preventing or treating candidiasis |
EP3898676A1 (en) | 2018-12-21 | 2021-10-27 | OSE Immunotherapeutics | Bifunctional anti-pd-1/sirpa molecule |
EP3898677A1 (en) | 2018-12-21 | 2021-10-27 | OSE Immunotherapeutics | Bifunctional anti-pd-1/il-7 molecule |
US20220025050A1 (en) | 2018-12-21 | 2022-01-27 | Ose Immunotherapeutics | Bifunctional molecule directed against human pd-1 |
WO2020141199A1 (en) | 2019-01-03 | 2020-07-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for enhancing cd8+ t cell-dependent immune responses in subjects suffering from cancer |
WO2020146627A1 (en) | 2019-01-10 | 2020-07-16 | California Institute Of Technology | A synthetic system for tunable thresholding of protein signals |
CA3126741A1 (en) | 2019-01-15 | 2020-07-23 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Mutated interleukin-34 (il-34) polypeptides and uses thereof in therapy |
WO2020148349A1 (en) | 2019-01-16 | 2020-07-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Variants of erythroferrone and their use |
AU2020208397A1 (en) | 2019-01-16 | 2021-08-12 | Compass Therapeutics Llc | Formulations of antibodies that bind human CD137 and uses thereof |
TWI756621B (zh) | 2019-01-25 | 2022-03-01 | 大陸商信達生物製藥(蘇州)有限公司 | 新型雙特異性抗體分子以及同時結合pd-l1和lag-3的雙特異性抗體 |
GB201901608D0 (en) | 2019-02-06 | 2019-03-27 | Vib Vzw | Vaccine adjuvant conjugates |
WO2020165374A1 (en) | 2019-02-14 | 2020-08-20 | Ose Immunotherapeutics | Bifunctional molecule comprising il-15ra |
CA3129317A1 (en) | 2019-02-15 | 2020-08-20 | Integral Molecular, Inc. | Antibodies comprising a common light chain and uses thereof |
US10871640B2 (en) | 2019-02-15 | 2020-12-22 | Perkinelmer Cellular Technologies Germany Gmbh | Methods and systems for automated imaging of three-dimensional objects |
MA54955A (fr) | 2019-02-15 | 2021-12-22 | Integral Molecular Inc | Anticorps anti-claudine 6 et leurs utilisations |
WO2020169707A1 (en) | 2019-02-21 | 2020-08-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Foxo1 inhibitor for use in the treatment of latent virus infection |
WO2020172571A1 (en) | 2019-02-21 | 2020-08-27 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
AU2020224680A1 (en) | 2019-02-21 | 2021-09-16 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to T cells and uses thereof to treat autoimmune disorders |
JP2022521750A (ja) | 2019-02-21 | 2022-04-12 | マレンゴ・セラピューティクス,インコーポレーテッド | カルレティキュリンに結合する多機能性分子およびその使用 |
AU2020226904A1 (en) | 2019-02-21 | 2021-09-16 | Marengo Therapeutics, Inc. | Anti-TCR antibody molecules and uses thereof |
CN114127111A (zh) | 2019-02-21 | 2022-03-01 | 马伦戈治疗公司 | 与nkp30结合的抗体分子及其用途 |
US20220088075A1 (en) | 2019-02-22 | 2022-03-24 | The Trustees Of The University Of Pennsylvania | Combination therapies of egfrviii chimeric antigen receptors and pd-1 inhibitors |
US11242407B2 (en) | 2019-02-26 | 2022-02-08 | Inspirna, Inc. | High-affinity anti-MERTK antibodies and uses thereof |
EP3930757A1 (en) | 2019-03-01 | 2022-01-05 | President And Fellows Of Harvard College | Methods and compositions for protein delivery |
EP3935159A1 (en) | 2019-03-08 | 2022-01-12 | Obsidian Therapeutics, Inc. | Human carbonic anhydrase 2 compositions and methods for tunable regulation |
WO2020185069A1 (en) | 2019-03-08 | 2020-09-17 | Linxis B.V. | Internalizing binding molecules targeting receptors involved in cell proliferation or cell differentiation |
WO2020198731A2 (en) | 2019-03-28 | 2020-10-01 | Danisco Us Inc | Engineered antibodies |
WO2020193740A1 (en) | 2019-03-28 | 2020-10-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New strategy for treating pancreatic cancer |
MA55519A (fr) | 2019-03-29 | 2022-02-09 | Atarga Llc | Anticorps anti-fgf23 |
EP3946261A1 (en) | 2019-04-03 | 2022-02-09 | President And Fellows Of Harvard College | Ionic liquids for drug delivery |
WO2020208082A1 (en) | 2019-04-09 | 2020-10-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for treating cmv related diseases |
US20220168389A1 (en) | 2019-04-12 | 2022-06-02 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
AU2020266750A1 (en) | 2019-04-29 | 2021-11-25 | Confo Therapeutics N.V. | Screening methods and assays for use with transmembrane proteins, in particular with GPCRS |
US20220289837A1 (en) | 2019-04-30 | 2022-09-15 | Vib Vzw | Cystic Fibrosis Transmembrane Conductance Regulator Stabilizing Agents |
WO2020231992A1 (en) | 2019-05-13 | 2020-11-19 | Regeneron Pharmaceuticals, Inc. | Improved competitive ligand binding assays |
JP2022533591A (ja) | 2019-05-14 | 2022-07-25 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | リンホトキシンアルファ遮断剤によりターゲットされた制御性t細胞及びその使用 |
SG11202112637TA (en) | 2019-05-14 | 2021-12-30 | Harpoon Therapeutics Inc | EpCAM BINDING PROTEINS AND METHODS OF USE |
EP3969472A1 (en) | 2019-05-16 | 2022-03-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method to treat type 2 inflammation or mast-cell dependent disease |
US20230071196A1 (en) | 2019-05-21 | 2023-03-09 | Novartis Ag | Variant cd58 domains and uses thereof |
AU2020279224A1 (en) | 2019-05-21 | 2021-12-16 | Novartis Ag | Trispecific binding molecules against BCMA and uses thereof |
US20210139585A1 (en) | 2019-05-21 | 2021-05-13 | Novartis Ag | Cd19 binding molecules and uses thereof |
WO2020238730A1 (zh) | 2019-05-24 | 2020-12-03 | 三优生物医药(上海)有限公司 | 新型cldn18.2结合分子 |
WO2020239945A1 (en) | 2019-05-28 | 2020-12-03 | Vib Vzw | Cancer treatment by targeting plexins in the immune compartment |
EP3976067A1 (en) | 2019-05-28 | 2022-04-06 | Vib Vzw | Cd8+ t-cells lacking plexins and their application in cancer treatment |
GB2584441A (en) | 2019-06-03 | 2020-12-09 | Fenomark Diagnostics Ab | Medical uses, methods and uses |
TW202100560A (zh) | 2019-06-04 | 2021-01-01 | 大陸商上海吉倍生物技術有限公司 | 一種抗ceacam5 的單殖株抗體及其製備方法和用途 |
CA3141561A1 (en) | 2019-06-12 | 2020-12-17 | Novartis Ag | Natriuretic peptide receptor 1 antibodies and methods of use |
WO2020257289A2 (en) | 2019-06-17 | 2020-12-24 | Visterra, Inc. | Humanized antibody molecules to cd138 and uses thereof |
CN114206938A (zh) | 2019-06-20 | 2022-03-18 | 国家医疗保健研究所 | 抗蛋白酶nexin-1构象单域抗体及其用途 |
KR20220066035A (ko) | 2019-06-21 | 2022-05-23 | 소리소 파마슈티컬스 인크. | 폴리펩타이드 |
JP2022538083A (ja) | 2019-06-21 | 2022-08-31 | ソリッソ ファーマシューティカルズ,インク. | ポリペプチド |
AU2020295767A1 (en) | 2019-06-21 | 2022-02-17 | Sorriso Pharmaceuticals, Inc. | Compositions |
US11642409B2 (en) | 2019-06-26 | 2023-05-09 | Massachusetts Insttute of Technology | Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof |
CN114466863A (zh) | 2019-07-01 | 2022-05-10 | 苏州康宁杰瑞生物科技有限公司 | 百日咳毒素结合蛋白 |
WO2021001539A1 (en) | 2019-07-04 | 2021-01-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New strategy to detect and treat eosinophilic fasciitis |
EP3999538A1 (en) | 2019-07-15 | 2022-05-25 | Intervet International B.V. | Caninized antibodies against canine ctla-4 |
CA3147757A1 (en) | 2019-07-26 | 2021-02-04 | Visterra, Inc. | Interleukin-2 agents and uses thereof |
EP4010079A1 (en) | 2019-08-05 | 2022-06-15 | Stichting VU | Identification and elimination of hcmv-infected cells |
CR20220076A (es) | 2019-08-30 | 2022-06-24 | Agenus Inc | Anticuerpos anti-cd96 y sus métodos de uso |
CN114616250A (zh) | 2019-09-04 | 2022-06-10 | 豪夫迈·罗氏有限公司 | Cd8结合剂及其用途 |
WO2021044012A1 (en) | 2019-09-05 | 2021-03-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method of treatment and pronostic of acute myeloid leukemia |
WO2021046451A1 (en) | 2019-09-06 | 2021-03-11 | Obsidian Therapeutics, Inc. | Compositions and methods for dhfr tunable protein regulation |
WO2021055329A1 (en) | 2019-09-16 | 2021-03-25 | Surface Oncology, Inc. | Anti-cd39 antibody compositions and methods |
TW202124446A (zh) | 2019-09-18 | 2021-07-01 | 瑞士商諾華公司 | 與entpd2抗體之組合療法 |
EP4031578A1 (en) | 2019-09-18 | 2022-07-27 | Novartis AG | Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies |
TW202128752A (zh) | 2019-09-25 | 2021-08-01 | 美商表面腫瘤學公司 | 抗il﹘27抗體及其用途 |
US20220290151A1 (en) | 2019-09-27 | 2022-09-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of müllerian inhibiting substance inhibitors for treating cancer |
TW202126295A (zh) | 2019-09-27 | 2021-07-16 | 大陸商江蘇挪貝肽醫藥科技有限公司 | 一種治療心境障礙的方法 |
TW202128756A (zh) | 2019-10-02 | 2021-08-01 | 德商百靈佳殷格翰國際股份有限公司 | 用於癌症治療之多重專一性結合蛋白 |
EP3799881A1 (en) | 2019-10-04 | 2021-04-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Single domain antibodies specifically binding globo - series glycans |
BR112022007376A2 (pt) | 2019-10-21 | 2022-07-05 | Novartis Ag | Terapias de combinação com venetoclax e inibidores de tim-3 |
WO2021078786A1 (en) | 2019-10-21 | 2021-04-29 | Vib Vzw | Nanodisc-specific antigen-binding chimeric proteins |
JP2022553306A (ja) | 2019-10-21 | 2022-12-22 | ノバルティス アーゲー | Tim-3阻害剤およびその使用 |
WO2021080682A1 (en) | 2019-10-24 | 2021-04-29 | Massachusetts Institute Of Technology | Monoclonal antibodies that bind human cd161 and uses thereof |
US20230002785A1 (en) | 2019-10-28 | 2023-01-05 | Georgia Tech Research Corporation | Mrna-encoded antibodies for contraception |
WO2021086953A1 (en) | 2019-10-28 | 2021-05-06 | Georgia Tech Research Corporation | Compositions and methods for prophylaxis of hiv |
KR20220110208A (ko) | 2019-11-05 | 2022-08-05 | 셀진 코포레이션 | 항-bcma 키메라 항원 수용체의 용도 |
US20220386594A1 (en) | 2019-11-11 | 2022-12-08 | Ibi-Ag Innovative Bio Insecticides Ltd. | Insect control nanobodies and uses thereof |
CN116249779A (zh) | 2019-11-12 | 2023-06-09 | 阿克蒂姆治疗有限公司 | 免疫刺激细菌递送平台及其用于递送治疗产物的用途 |
CA3158963A1 (en) | 2019-11-22 | 2021-05-27 | Samir Mitragotri | Ionic liquids for drug delivery |
EP4065158A2 (en) | 2019-11-26 | 2022-10-05 | Novartis AG | Chimeric antigen receptors binding bcma and cd19 and uses thereof |
CA3158991A1 (en) | 2019-11-27 | 2021-06-03 | Vib Vzw | Positive allosteric modulators of the calcium-sensing receptor |
WO2021105384A1 (en) | 2019-11-27 | 2021-06-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Targeting the nls region of nupr1 protein to treat cancer |
WO2021105391A1 (en) | 2019-11-27 | 2021-06-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combination comprising nupr1 inhibitors to treat cancer |
CN115151309A (zh) | 2019-12-05 | 2022-10-04 | Ose免疫疗法 | 抗clec-1a抗体及其抗原结合片段 |
KR20220111313A (ko) | 2019-12-06 | 2022-08-09 | 아블린쓰 엔.브이. | TNFα 및 OX40L을 표적으로 하는 면역글로불린 단일 가변 도메인을 포함하는 폴리펩티드 |
US11897950B2 (en) | 2019-12-06 | 2024-02-13 | Augusta University Research Institute, Inc. | Osteopontin monoclonal antibodies |
MX2022006880A (es) | 2019-12-06 | 2022-07-11 | Ablynx Nv | Polipeptidos que comprenden dominios variables unicos de inmunoglobulina dirigidos a tnf alfa e il-23. |
WO2021116119A1 (en) | 2019-12-09 | 2021-06-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antibodies having specificity to her4 and uses thereof |
IL293548A (en) | 2019-12-09 | 2022-08-01 | Ablynx Nv | Polypeptides comprising immunoglobulin with single variable domains targeting 13 il and tsl |
GB201918279D0 (en) | 2019-12-12 | 2020-01-29 | Vib Vzw | Glycosylated single chain immunoglobulin domains |
WO2021122866A1 (en) | 2019-12-17 | 2021-06-24 | Ose Immunotherapeutics | Bifunctional molecules comprising an il-7 variant |
BR112022011902A2 (pt) | 2019-12-20 | 2022-09-06 | Novartis Ag | Terapias de combinação |
WO2021123360A1 (en) | 2019-12-20 | 2021-06-24 | Vib Vzw | Nanobody exchange chromatography |
US11725048B2 (en) | 2019-12-20 | 2023-08-15 | Hudson Institute of Medical Research | CXCL10 binding proteins and compositions thereof |
EP4084821A4 (en) | 2020-01-03 | 2024-04-24 | Marengo Therapeutics Inc | CD33-BINDING MULTIFUNCTIONAL MOLECULES AND THEIR USES |
WO2021142002A1 (en) | 2020-01-06 | 2021-07-15 | Vaccinex, Inc. | Anti-ccr8 antibodies and uses thereof |
WO2021140205A1 (en) | 2020-01-10 | 2021-07-15 | Confo Therapeutics N.V. | Methods for generating antibodies and antibody fragments and libraries comprising same |
TW202140553A (zh) | 2020-01-13 | 2021-11-01 | 美商威特拉公司 | C5ar1抗體分子及其用途 |
CA3167413A1 (en) | 2020-01-17 | 2021-07-22 | Novartis Ag | Combination comprising a tim-3 inhibitor and a hypomethylating agent for use in treating myelodysplastic syndrome or chronic myelomonocytic leukemia |
US20230076670A1 (en) | 2020-01-17 | 2023-03-09 | Universiteit Gent | Immunoglobulin single domain antibodies for delivery of mucosal vaccines |
WO2021156490A2 (en) | 2020-02-06 | 2021-08-12 | Vib Vzw | Corona virus binders |
WO2021163618A1 (en) | 2020-02-14 | 2021-08-19 | Novartis Ag | Method of predicting response to chimeric antigen receptor therapy |
MX2022010175A (es) | 2020-02-21 | 2022-09-12 | Harpoon Therapeutics Inc | Proteinas de union a flt3 y metodos de uso. |
KR20230012464A (ko) | 2020-02-25 | 2023-01-26 | 브이아이비 브이지더블유 | 류신-풍부 반복 키나제 2 알로스테릭 조절제 |
WO2021173674A1 (en) | 2020-02-26 | 2021-09-02 | A2 Biotherapeutics, Inc. | Polypeptides targeting mage-a3 peptide-mhc complexes and methods of use thereof |
US20230256017A1 (en) | 2020-02-27 | 2023-08-17 | Jennifer Brogdon | Methods of making chimeric antigen receptor-expressing cells |
CN115397460A (zh) | 2020-02-27 | 2022-11-25 | 诺华股份有限公司 | 制备表达嵌合抗原受体的细胞的方法 |
AU2021232853A1 (en) | 2020-03-10 | 2022-09-22 | Massachusetts Institute Of Technology | Compositions and methods for immunotherapy of NPM1c-positive cancer |
AU2021236145A1 (en) | 2020-03-10 | 2022-09-22 | Dana-Farber Cancer Institute, Inc. | Methods for generating engineered memory-like NK cells and compositions thereof |
DE102020111571A1 (de) | 2020-03-11 | 2021-09-16 | Immatics US, Inc. | Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren |
CN115003333A (zh) | 2020-03-13 | 2022-09-02 | 江苏恒瑞医药股份有限公司 | Pvrig结合蛋白及其医药用途 |
US11365239B2 (en) | 2020-03-20 | 2022-06-21 | Tsb Therapeutics (Beijing) Co., Ltd. | Anti-SARS-COV-2 antibodies and uses thereof |
JP2023517765A (ja) | 2020-03-20 | 2023-04-26 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | ポリソルベートを検出する方法 |
US20230128499A1 (en) | 2020-03-27 | 2023-04-27 | Novartis Ag | Bispecific combination therapy for treating proliferative diseases and autoimmune diseases |
CA3175873A1 (en) | 2020-03-30 | 2021-10-07 | Ablynx Nv | Method for the production and purification of multivalent immunoglobulin single variable domains |
MX2022012376A (es) | 2020-03-31 | 2023-02-15 | Biotalys NV | Polipeptidos antifungicos. |
CN113461817A (zh) | 2020-03-31 | 2021-10-01 | 苏州泽璟生物制药股份有限公司 | 一种抗人cd47抗体及其抗原结合片段、制备方法和应用 |
CA3178465A1 (en) | 2020-04-03 | 2021-10-07 | Visterra, Inc. | Antibody molecule-drug conjugates and uses thereof |
US20230272056A1 (en) | 2020-04-09 | 2023-08-31 | Merck Sharp & Dohme Llc | Affinity matured anti-lap antibodies and uses thereof |
AU2021257848A1 (en) | 2020-04-15 | 2022-12-01 | Voyager Therapeutics, Inc. | Tau binding compounds |
CN116406287A (zh) | 2020-04-16 | 2023-07-07 | 巴黎公共医疗救助机构 | 治疗由病毒引起的补体介导的障碍的方法 |
EP4144758A1 (en) | 2020-04-22 | 2023-03-08 | Mabwell (Shanghai) Bioscience Co., Ltd. | Single variable domain antibody targeting human programmed death ligand 1 (pd-l1) and derivative thereof |
JP2023523011A (ja) | 2020-04-24 | 2023-06-01 | マレンゴ・セラピューティクス,インコーポレーテッド | T細胞関連のがん細胞に結合する多機能性分子およびその使用 |
IL297412A (en) | 2020-05-04 | 2022-12-01 | Immunorizon Ltd | Advance trispecific antibodies and methods for their use |
CA3180683A1 (en) | 2020-05-12 | 2021-11-18 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | New method to treat cutaneous t-cell lymphomas and tfh derived lymphomas |
WO2021229104A1 (en) | 2020-05-15 | 2021-11-18 | Université de Liège | Anti-cd38 single-domain antibodies in disease monitoring and treatment |
US20230192879A1 (en) | 2020-05-19 | 2023-06-22 | Institut Curie | Methods for the diagnosis and treatment of cytokine release syndrome |
JP2023504675A (ja) | 2020-05-19 | 2023-02-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ガンの処置のための結合分子 |
EP3916088A1 (en) | 2020-05-28 | 2021-12-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins comprising the sars-cov-2 3clpro catalytic domain and their uses for screening anti-sars-cov-2 agents |
US20230173095A1 (en) | 2020-05-29 | 2023-06-08 | President And Fellows Of Harvard College | Living cells engineered with polyphenol-functionalized biologically active nanocomplexes |
CN111647077B (zh) | 2020-06-02 | 2021-02-09 | 深圳市因诺赛生物科技有限公司 | 新型冠状病毒(sars-cov-2)刺突蛋白结合分子及其应用 |
PE20231078A1 (es) | 2020-06-02 | 2023-07-17 | Arcus Biosciences Inc | Anticuerpos anti-tigit |
AU2021288224A1 (en) | 2020-06-11 | 2023-01-05 | Novartis Ag | ZBTB32 inhibitors and uses thereof |
US20230218608A1 (en) | 2020-06-18 | 2023-07-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New strategy for treating pancreatic cancer |
MX2022016591A (es) | 2020-06-24 | 2023-04-20 | Visterra Inc | Moléculas de anticuerpo contra april y usos de las mismas. |
CN115884986A (zh) | 2020-06-29 | 2023-03-31 | Inserm(法国国家健康医学研究院) | 抗蛋白s单域抗体和包含其的多肽 |
WO2022003156A1 (en) | 2020-07-02 | 2022-01-06 | Oncurious Nv | Ccr8 non-blocking binders |
KR20230035079A (ko) | 2020-07-03 | 2023-03-10 | 수조우 알파맵 씨오., 엘티디. | 응고인자 xi(fxi) 결합 단백질 |
EP4182025A1 (en) | 2020-07-16 | 2023-05-24 | Novartis AG | Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules |
JP2023535708A (ja) | 2020-07-21 | 2023-08-21 | スーチョウ スマートヌクライド バイオファーマシューティカル カンパニー リミテッド | Cd8結合ポリペプチドおよびその使用 |
EP4185612A1 (en) | 2020-07-23 | 2023-05-31 | Othair Prothena Limited | Anti-abeta antibodies |
WO2022026592A2 (en) | 2020-07-28 | 2022-02-03 | Celltas Bio, Inc. | Antibody molecules to coronavirus and uses thereof |
CA3190516A1 (en) | 2020-07-31 | 2022-02-03 | Biotalys NV | Expression host |
AU2021324883A1 (en) | 2020-08-12 | 2023-03-23 | Actym Therapeutics, Inc. | Immunostimulatory bacteria-based vaccines, therapeutics, and rna delivery platforms |
WO2022040631A1 (en) | 2020-08-21 | 2022-02-24 | Immatics US, Inc. | Methods for isolating cd8+ selected t cells |
KR20230074487A (ko) | 2020-08-26 | 2023-05-30 | 마렝고 테라퓨틱스, 인크. | Trbc1 또는 trbc2를 검출하는 방법 |
EP4204096A2 (en) | 2020-08-26 | 2023-07-05 | Marengo Therapeutics, Inc. | Antibody molecules that bind to nkp30 and uses thereof |
AU2021331075A1 (en) | 2020-08-26 | 2023-04-06 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
EP4204021A1 (en) | 2020-08-31 | 2023-07-05 | Advanced Accelerator Applications International S.A. | Method of treating psma-expressing cancers |
EP4204020A1 (en) | 2020-08-31 | 2023-07-05 | Advanced Accelerator Applications International S.A. | Method of treating psma-expressing cancers |
US20230365675A1 (en) | 2020-09-14 | 2023-11-16 | Vor Biopharma Inc. | Single domain antibodies against cd33 |
WO2022060806A1 (en) | 2020-09-16 | 2022-03-24 | Obsidian Therapeutics, Inc. | Compositions and methods for expression of anti-bcma chimeric antigen receptors with small molecule-regulated il15 in t cells |
JP2023541934A (ja) | 2020-09-16 | 2023-10-04 | リンクシス ベスローテン フェンノートシャップ | 内在化結合分子 |
WO2022063947A1 (en) | 2020-09-24 | 2022-03-31 | Vib Vzw | Combination of p2y6 inhibitors and immune checkpoint inhibitors |
WO2022063957A1 (en) | 2020-09-24 | 2022-03-31 | Vib Vzw | Biomarker for anti-tumor therapy |
KR20230074527A (ko) | 2020-09-25 | 2023-05-30 | 아블린쓰 엔.브이. | Il-13 및 ox40l을 표적으로 하는 면역글로불린 단일 가변 도메인을 포함하는 폴리펩티드 |
TW202233668A (zh) | 2020-10-21 | 2022-09-01 | 德商百靈佳殷格翰國際股份有限公司 | 用於治療眼部疾病之雙特異性抗-VEGF及抗-TrkB結合分子 |
EP4232064A1 (en) | 2020-10-21 | 2023-08-30 | Institut National de la Santé et de la Recherche Médicale (INSERM) | C-terminal sparc fragments for treating cancer |
KR20230113755A (ko) | 2020-11-04 | 2023-08-01 | 셀진 코포레이션 | 선행 항암 알킬화제 요법을 받은 환자에서의 car t 세포 요법 |
WO2022097061A1 (en) | 2020-11-06 | 2022-05-12 | Novartis Ag | Anti-cd19 agent and b cell targeting agent combination therapy for treating b cell malignancies |
WO2022097060A1 (en) | 2020-11-06 | 2022-05-12 | Novartis Ag | Cd19 binding molecules and uses thereof |
CN112480248B (zh) | 2020-11-24 | 2023-05-05 | 三优生物医药(上海)有限公司 | 与cld18a2特异性结合的分子 |
US20240018248A1 (en) | 2020-12-02 | 2024-01-18 | Vib Vzw | An ltbr agonist in combination therapy against cancer |
WO2022117569A1 (en) | 2020-12-02 | 2022-06-09 | Oncurious Nv | A ccr8 antagonist antibody in combination with a lymphotoxin beta receptor agonist antibody in therapy against cancer |
TW202237171A (zh) | 2020-12-04 | 2022-10-01 | 美商威特拉公司 | 使用介白素-2藥劑之方法 |
CA3201219A1 (en) | 2020-12-04 | 2022-06-09 | Mir Ali | Ionizable cationic lipids and lipid nanoparticles, and methods of synthesis and use thereof |
KR20230117383A (ko) | 2020-12-04 | 2023-08-08 | 셀진 코포레이션 | 염증-관련 가용성 인자의 억제제와 조합된 키메라 항원수용체 (car) t-세포 요법의 용도 |
WO2022130182A1 (en) | 2020-12-14 | 2022-06-23 | Novartis Ag | Reversal binding agents for anti-natriuretic peptide receptor 1 (npr1) antibodies and uses thereof |
US20240067727A1 (en) | 2020-12-17 | 2024-02-29 | Ose Immunotherapeutics | Bifunctional anti-pd1/il-7 molecules |
EP4263610A1 (en) | 2020-12-18 | 2023-10-25 | Ablynx N.V. | T cell recruiting polypeptides based on tcr alpha/beta reactivity |
TW202241947A (zh) | 2020-12-18 | 2022-11-01 | 比利時商艾伯霖克斯公司 | 包含靶向磷脂醯肌醇蛋白聚糖—3和t細胞受體的免疫球蛋白單可變結構域的多肽 |
TW202239763A (zh) | 2020-12-18 | 2022-10-16 | 比利時商艾伯霖克斯公司 | 包含靶向IL-6和TNF-α的免疫球蛋白單可變結構域的多肽 |
GB202020502D0 (en) | 2020-12-23 | 2021-02-03 | Vib Vzw | Antibody composistion for treatment of corona virus infection |
EP4267617A1 (en) | 2020-12-24 | 2023-11-01 | Vib Vzw | Human ccr8 binders |
WO2022136649A1 (en) | 2020-12-24 | 2022-06-30 | Oncurious Nv | Non-blocking human ccr8 binders |
WO2022136650A1 (en) | 2020-12-24 | 2022-06-30 | Oncurious Nv | Murine cross-reactive human ccr8 binders |
TW202245825A (zh) | 2021-01-20 | 2022-12-01 | 美商威特拉公司 | 介白素-2藥劑及其用途 |
GB2603166A (en) | 2021-01-29 | 2022-08-03 | Thelper As | Therapeutic and Diagnostic Agents and Uses Thereof |
WO2022162569A1 (en) | 2021-01-29 | 2022-08-04 | Novartis Ag | Dosage regimes for anti-cd73 and anti-entpd2 antibodies and uses thereof |
WO2022161502A1 (zh) | 2021-02-01 | 2022-08-04 | 羿尊生物医药(浙江)有限公司 | 一种靶向蛋白降解系统及其应用 |
CN117794566A (zh) | 2021-02-05 | 2024-03-29 | Vib研究所 | 沙贝病毒结合剂 |
US20240101647A1 (en) | 2021-02-05 | 2024-03-28 | Vib Vzw | Sarbecovirus binders |
AU2022217812A1 (en) | 2021-02-05 | 2023-08-03 | Salubris Biotherapeutics, Inc. | Il-15 fusion proteins and methods of making and using same |
EP4291898A1 (en) | 2021-02-12 | 2023-12-20 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Method for prognosis and treating a patient suffering from cancer |
CN117241804A (zh) | 2021-02-17 | 2023-12-15 | 非营利性组织佛兰芒综合大学生物技术研究所 | 在癌症治疗中slc4a4的抑制 |
IL305318A (en) | 2021-02-19 | 2023-10-01 | Vib Vzw | Cation-independent mannose-6-phosphate receptor binders |
EP4296284A1 (en) | 2021-02-19 | 2023-12-27 | SHAPERON Inc. | Bispecific single domain antibody to pd-l1 and cd47 and use thereof |
AU2022224636A1 (en) | 2021-02-19 | 2023-09-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Single domain antibodies that neutralize sars-cov-2 |
BR112023016706A2 (pt) | 2021-02-19 | 2023-10-31 | Seoul Nat Univ R&Db Foundation | Anticorpo ou um fragmento de ligação ao antígeno do mesmo, molécula de ácido nucleico, métodos para produzir um anticorpo ou um fragmento de ligação ao antígeno do mesmo e para detectar agrupamento de diferenciação 47 ou determinar uma quantidade de agrupamento de diferenciação 47 em uma amostra, e, uso do anticorpo ou de um fragmento de ligação ao antígeno do mesmo |
EP4296282A1 (en) | 2021-02-19 | 2023-12-27 | SHAPERON Inc. | Single domain antibody against cd47 and use thereof |
CN117321418A (zh) | 2021-03-18 | 2023-12-29 | 诺华股份有限公司 | 癌症生物标志物及其使用方法 |
GB202104104D0 (en) | 2021-03-24 | 2021-05-05 | Liliumx Ltd | Platform and method |
WO2022199804A1 (en) | 2021-03-24 | 2022-09-29 | Vib Vzw | Nek6 inhibition to treat als and ftd |
EP4314068A1 (en) | 2021-04-02 | 2024-02-07 | The Regents Of The University Of California | Antibodies against cleaved cdcp1 and uses thereof |
JP2024513906A (ja) | 2021-04-07 | 2024-03-27 | センチュリー セラピューティクス,インコーポレイテッド | 人工多能性幹細胞からアルファ-ベータt細胞を生成するための組成物および方法 |
WO2022216524A1 (en) | 2021-04-07 | 2022-10-13 | Century Therapeutics, Inc. | Combined artificial cell death/reporter system polypeptide for chimeric antigen receptor cell and uses thereof |
TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗TGFβ抗體及其他治療劑用於治療增殖性疾病之用途 |
BR112023018844A2 (pt) | 2021-04-07 | 2023-10-10 | Century Therapeutics Inc | Composições e métodos para geração de células t gama-delta de células-tronco pluripotentes induzidas |
WO2022216993A2 (en) | 2021-04-08 | 2022-10-13 | Marengo Therapeutics, Inc. | Multifuntional molecules binding to tcr and uses thereof |
EP4320229A1 (en) | 2021-04-09 | 2024-02-14 | Stichting Radboud Universiteit | Off the shelf proximity biotinylation enzyme |
IL307419A (en) | 2021-04-09 | 2023-12-01 | Ose Immunotherapeutics | A new scaffold for bifunctional molecules with improved properties |
WO2022214652A1 (en) | 2021-04-09 | 2022-10-13 | Ose Immunotherapeutics | Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains |
EP4322937A1 (en) | 2021-04-14 | 2024-02-21 | Institut National de la Santé et de la Recherche Médicale (INSERM) | New method to improve the anti-tumoral activity of macrophages |
EP4322938A1 (en) | 2021-04-14 | 2024-02-21 | Institut National de la Santé et de la Recherche Médicale (INSERM) | New method to improve nk cells cytotoxicity |
EP4322991A1 (en) | 2021-04-16 | 2024-02-21 | Celgene Corporation | T cell therapy in patients who have had prior stem cell transplant |
IL308183A (en) | 2021-05-04 | 2024-01-01 | Regeneron Pharma | Multispecific FGF21 receptor agonists and their uses |
KR20240005809A (ko) | 2021-05-07 | 2024-01-12 | 서피스 온콜로지, 엘엘씨 | 항-il-27 항체 및 이의 용도 |
WO2022242892A1 (en) | 2021-05-17 | 2022-11-24 | Université de Liège | Anti-cd38 single-domain antibodies in disease monitoring and treatment |
WO2022253910A1 (en) | 2021-06-02 | 2022-12-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A new method to treat an inflammatory skin disease |
AU2021451307A1 (en) | 2021-06-16 | 2024-02-01 | Shanghai Sinobay Biotechnology Co., Ltd. | Antibody targeting axl protein and antigen binding fragment thereof, preparation method therefor and use thereof |
EP4355778A1 (en) | 2021-06-17 | 2024-04-24 | Boehringer Ingelheim International GmbH | Novel tri-specific binding molecules |
IL309579A (en) | 2021-06-22 | 2024-02-01 | Merck Patent Gmbh | VHH-based NKP30 binders |
CA3225194A1 (en) | 2021-06-23 | 2022-12-29 | Vib Vzw | Means and methods for selection of specific binders |
US20230174651A1 (en) | 2021-06-23 | 2023-06-08 | Janssen Biotech, Inc. | Materials and methods for hinge regions in functional exogenous receptors |
CN114230665B (zh) | 2021-06-23 | 2024-03-22 | 苏州智核生物医药科技有限公司 | CD8α结合多肽及其用途 |
CN117580865A (zh) | 2021-06-29 | 2024-02-20 | 山东先声生物制药有限公司 | Cd16抗体及其应用 |
WO2023288046A1 (en) | 2021-07-15 | 2023-01-19 | President And Fellows Of Harvard College | Compositions and methods relating to cells with adhered particles |
CN117751143A (zh) | 2021-07-30 | 2024-03-22 | 山东先声生物制药有限公司 | 抗pvrig/抗tigit双特异性抗体和应用 |
WO2023016828A2 (en) | 2021-07-30 | 2023-02-16 | Vib Vzw | Cation-independent mannose-6-phosphate receptor binders for targeted protein degradation |
WO2023012343A1 (en) | 2021-08-06 | 2023-02-09 | Institut Du Cancer De Montpellier | Methods for the treatment of cancer |
WO2023023220A1 (en) | 2021-08-20 | 2023-02-23 | Alexion Pharmaceuticals, Inc. | Methods for treating sickle cell disease or beta thalassemia using a complement alternative pathway inhibitor |
WO2023023227A1 (en) | 2021-08-20 | 2023-02-23 | Alexion Pharmaceuticals, Inc. | Methods for treating sickle cell disease or beta thalassemia using complement alternative pathway inhibitors |
CN117616049A (zh) | 2021-08-24 | 2024-02-27 | 江苏恒瑞医药股份有限公司 | Fap/cd40结合分子及其医药用途 |
WO2023040935A1 (zh) | 2021-09-15 | 2023-03-23 | 江苏恒瑞医药股份有限公司 | 一种含抗pvrig/tigit双特异性抗体的药物组合物 |
WO2023041985A2 (en) | 2021-09-15 | 2023-03-23 | New York University In Abu Dhabicorporation | Compositions that block activation of the sars-cov-2 replication and transcription complex (rtc) and methods of use thereof |
TW202328195A (zh) | 2021-09-15 | 2023-07-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 特異性結合pd-1的蛋白及其醫藥用途 |
WO2023041744A1 (en) | 2021-09-17 | 2023-03-23 | Institut Curie | Bet inhibitors for treating pab1 deficient cancer |
WO2023041805A1 (en) | 2021-09-20 | 2023-03-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for improving the efficacy of hdac inhibitor therapy and predicting the response to treatment with hdac inhibitor |
WO2023044483A2 (en) | 2021-09-20 | 2023-03-23 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of her2 positive cancer |
WO2023057484A1 (en) | 2021-10-06 | 2023-04-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting and improving the efficacy of mcl-1 inhibitor therapy |
WO2023057601A1 (en) | 2021-10-06 | 2023-04-13 | Biotalys NV | Anti-fungal polypeptides |
WO2023059846A1 (en) | 2021-10-08 | 2023-04-13 | President And Fellows Of Harvard College | Ionic liquids for drug delivery |
WO2023073099A1 (en) | 2021-10-28 | 2023-05-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method to improve phagocytosis |
WO2023078906A1 (en) | 2021-11-03 | 2023-05-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for treating acute myeloid leukemia |
WO2023079137A1 (en) | 2021-11-05 | 2023-05-11 | Katholieke Universiteit Leuven | Neutralizing anti-sars-cov-2 human antibodies |
EP4177266A1 (en) | 2021-11-05 | 2023-05-10 | Katholieke Universiteit Leuven | Neutralizing anti-sars-cov-2 human antibodies |
WO2023086796A2 (en) | 2021-11-09 | 2023-05-19 | Actym Therapeutics, Inc. | Immunostimulatory bacteria for converting macrophages into a phenotype amenable to treatment, and companion diagnostic for identifying subjects for treatment |
WO2023083890A1 (en) | 2021-11-09 | 2023-05-19 | Ose Immunotherapeutics | Identification of clec-1 ligand and uses thereof |
EP4180518A1 (en) | 2021-11-12 | 2023-05-17 | Istituto Europeo di Oncologia S.r.l. | T cells and uses thereof |
WO2023092004A1 (en) | 2021-11-17 | 2023-05-25 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of tau-related disorders |
WO2023089032A1 (en) | 2021-11-19 | 2023-05-25 | Institut Curie | Methods for the treatment of hrd cancer and brca-associated cancer |
WO2023089159A1 (en) | 2021-11-22 | 2023-05-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New strategy targeting stroma/tumor cell crosstalk to treat a cancer |
WO2023089191A1 (en) | 2021-11-22 | 2023-05-25 | Ablynx N.V. | Obtaining sequence information for target multivalent immunoglobulin single variable domains |
US20230348614A1 (en) | 2021-11-24 | 2023-11-02 | Visterra, Inc. | Engineered antibody molecules to cd138 and uses thereof |
WO2023095034A1 (en) | 2021-11-24 | 2023-06-01 | Novartis Ag | Modulators of adeno-associated virus transduction and uses thereof |
TW202333772A (zh) | 2021-12-01 | 2023-09-01 | 美商威特拉公司 | 使用介白素-2藥劑之方法 |
WO2023099763A1 (en) | 2021-12-03 | 2023-06-08 | Institut Curie | Sirt6 inhibitors for use in treating resistant hrd cancer |
WO2023114884A2 (en) | 2021-12-15 | 2023-06-22 | Interius Biotherapeutics, Inc. | Pseudotyped viral particles, compositions comprising the same, and uses thereof |
WO2023111266A1 (en) | 2021-12-17 | 2023-06-22 | Ablynx Nv | POLYPEPTIDES COMPRISING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS TARGETING TCRαβ, CD33 AND CD123 |
EP4209508A1 (en) | 2022-01-11 | 2023-07-12 | Centre national de la recherche scientifique | Nanobodies for the deneddylating enzyme nedp1 |
WO2023135198A1 (en) | 2022-01-12 | 2023-07-20 | Vib Vzw | Human ntcp binders for therapeutic use and liver-specific targeted delivery |
GB202201137D0 (en) | 2022-01-28 | 2022-03-16 | Thelper As | Therapeutic and diagnostic agents and uses thereof |
WO2023148291A1 (en) | 2022-02-02 | 2023-08-10 | Biotalys NV | Methods for genome editing |
WO2023148397A1 (en) | 2022-02-07 | 2023-08-10 | Vib Vzw | Engineered stabilizing aglycosylated fc-regions |
TW202342548A (zh) | 2022-02-07 | 2023-11-01 | 美商威特拉公司 | 抗獨特型(anti-idiotype)抗體分子及其用途 |
WO2023151894A1 (en) | 2022-02-11 | 2023-08-17 | Henkel Ag & Co. Kgaa | Process for the synthesis of alpha-methylene-gamma-butyrolactone |
WO2023164487A1 (en) | 2022-02-22 | 2023-08-31 | Brown University | Compositions and methods to achieve systemic uptake of particles following oral or mucosal administration |
WO2023183477A1 (en) | 2022-03-23 | 2023-09-28 | Bodhi Bio Llc | Compositions and methods for antigen-specific therapy |
WO2023187657A1 (en) | 2022-03-30 | 2023-10-05 | Novartis Ag | Methods of treating disorders using anti-natriuretic peptide receptor 1 (npr1) antibodies |
WO2023201238A1 (en) | 2022-04-11 | 2023-10-19 | Vor Biopharma Inc. | Binding agents and methods of use thereof |
WO2023198806A1 (en) | 2022-04-13 | 2023-10-19 | Ose Immunotherapeutics | New class of molecules for selective clearance of antibody |
WO2023198848A1 (en) | 2022-04-13 | 2023-10-19 | Vib Vzw | An ltbr agonist in combination therapy against cancer |
WO2023198851A1 (en) | 2022-04-14 | 2023-10-19 | Institut National de la Santé et de la Recherche Médicale | Methods for controlling the tumor cell killing by light |
WO2023212518A1 (en) | 2022-04-25 | 2023-11-02 | Visterra, Inc. | Antibody molecules to april and uses thereof |
WO2023212587A1 (en) | 2022-04-28 | 2023-11-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recombinant polypeptides comprising single-domain antibodies targeting herv-k subtype hml-2 |
WO2023213751A1 (en) | 2022-05-02 | 2023-11-09 | Umc Utrecht Holding B.V | Single domain antibodies for the detection of plasmin-cleaved vwf |
WO2023215719A1 (en) | 2022-05-02 | 2023-11-09 | Arcus Biosciences, Inc. | Anti-tigit antibodies and uses of the same |
WO2023217904A1 (en) | 2022-05-10 | 2023-11-16 | Institut National de la Santé et de la Recherche Médicale | Syncitin-1 fusion proteins and uses thereof for cargo delivery into target cells |
WO2023220641A2 (en) | 2022-05-11 | 2023-11-16 | Juno Therapeutics, Inc. | Methods and uses related to t cell therapy and production of same |
WO2023220647A1 (en) | 2022-05-11 | 2023-11-16 | Regeneron Pharmaceuticals, Inc. | Multispecific binding molecule proproteins and uses thereof |
WO2023220695A2 (en) | 2022-05-13 | 2023-11-16 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of her2 positive cancer |
WO2023222825A1 (en) | 2022-05-18 | 2023-11-23 | Vib Vzw | Sarbecovirus spike s2 subunit binders |
WO2023224715A1 (en) | 2022-05-19 | 2023-11-23 | Massachusetts Institute Of Technology | Car cells targeting an inserted ligand |
WO2023230548A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Method for predicting response to a t cell therapy |
US20240026001A1 (en) | 2022-05-25 | 2024-01-25 | Surface Oncology, Inc. | Use of anti-il-27 antibodies |
US20240025987A1 (en) | 2022-05-25 | 2024-01-25 | Surface Oncology, Inc. | Use of anti-il-27 antibodies |
WO2023232826A1 (en) | 2022-05-30 | 2023-12-07 | Ose Immunotherapeutics | Biomarkers of il7r modulator activity |
WO2023240124A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Pseudotyped viral particles for targeting tcr-expressing cells |
WO2023240109A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Multispecific molecules for modulating t-cell activity, and uses thereof |
WO2023240156A1 (en) | 2022-06-08 | 2023-12-14 | Tidal Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles, and methods of synthesis and use thereof |
WO2023242247A1 (en) | 2022-06-14 | 2023-12-21 | Ablynx Nv | Immunoglobulin single variable domains targeting t cell receptor |
EP4299125A1 (en) | 2022-06-30 | 2024-01-03 | Universite De Montpellier | Anti-mglur2 biparatopic nanobodies and uses thereof |
WO2024003873A1 (en) | 2022-06-30 | 2024-01-04 | Intrexon Actobiotics Nv D/B/A Precigen Actobio | Single variable domain antibodies against tumor necrosis factor-alpha |
EP4299124A1 (en) | 2022-06-30 | 2024-01-03 | Universite De Montpellier | Anti-mglur2 nanobodies for use as biomolecule transporter |
WO2024008755A1 (en) | 2022-07-04 | 2024-01-11 | Vib Vzw | Blood-cerebrospinal fluid barrier crossing antibodies |
WO2024008904A2 (en) | 2022-07-08 | 2024-01-11 | Novo Nordisk A/S | Highly potent isvd compounds capable of substituting for fviii(a) |
US20240052065A1 (en) | 2022-07-15 | 2024-02-15 | Boehringer Ingelheim International Gmbh | Binding molecules for the treatment of cancer |
US20240117038A1 (en) | 2022-07-18 | 2024-04-11 | Ablynx N.V. | Cx3cr1-binding compounds, methods and uses thereof |
WO2024018426A1 (en) | 2022-07-22 | 2024-01-25 | Janssen Biotech, Inc. | Enhanced transfer of genetic instructions to effector immune cells |
WO2024023271A1 (en) | 2022-07-27 | 2024-02-01 | Ablynx Nv | Polypeptides binding to a specific epitope of the neonatal fc receptor |
WO2024028347A1 (en) | 2022-08-01 | 2024-02-08 | Ose Immunotherapeutics | Heterodimeric fc-clec-1 fusion molecule and uses thereof |
WO2024028386A1 (en) | 2022-08-02 | 2024-02-08 | Ose Immunotherapeutics | Multifunctional molecule directed against cd28 |
WO2024030976A2 (en) | 2022-08-03 | 2024-02-08 | Voyager Therapeutics, Inc. | Compositions and methods for crossing the blood brain barrier |
WO2024028476A1 (en) | 2022-08-05 | 2024-02-08 | Institut National de la Santé et de la Recherche Médicale | Methods for the treatment of th2-mediated diseases |
WO2024037910A1 (en) | 2022-08-17 | 2024-02-22 | Institut National de la Santé et de la Recherche Médicale | Syk inhibitors for use in the treatment of cancer |
WO2024049951A1 (en) | 2022-08-31 | 2024-03-07 | Alexion Pharmaceuticals, Inc. | Dosage and administration of fusion polypeptides for treatment of sickle cell disease |
WO2024047110A1 (en) | 2022-08-31 | 2024-03-07 | Institut National de la Santé et de la Recherche Médicale | Method to generate more efficient car-t cells |
WO2024050524A1 (en) | 2022-09-01 | 2024-03-07 | University Of Georgia Research Foundation, Inc. | Compositions and methods for directing apolipoprotein l1 to induce mammalian cell death |
WO2024054436A1 (en) | 2022-09-06 | 2024-03-14 | Alexion Pharmaceuticals, Inc. | Diagnostic and prognostic biomarker profiles in patients with hematopoietic stem cell transplant-associated thrombotic microangiopathy (hsct-tma) |
WO2024055034A1 (en) | 2022-09-09 | 2024-03-14 | Yale University | Proteolysis targeting antibodies and methods of use thereof |
WO2024059739A1 (en) | 2022-09-15 | 2024-03-21 | Voyager Therapeutics, Inc. | Tau binding compounds |
WO2024056809A1 (en) | 2022-09-15 | 2024-03-21 | Novartis Ag | Treatment of autoimmune disorders using chimeric antigen receptor therapy |
WO2024068744A1 (en) | 2022-09-27 | 2024-04-04 | Vib Vzw | Antivirals against human parainfluenza virus |
WO2024069180A2 (en) | 2022-09-28 | 2024-04-04 | LiliumX Ltd. | Multivalent proteins and screening methods |
WO2024068944A1 (en) | 2022-09-30 | 2024-04-04 | Sanofi | Anti-cd28 antibodies |
WO2024074713A1 (en) | 2022-10-07 | 2024-04-11 | Institut National de la Santé et de la Recherche Médicale | Method to generate improving car-t cells |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
GB9016299D0 (en) * | 1990-07-25 | 1990-09-12 | Brien Caroline J O | Binding substances |
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1993
- 1993-08-18 DK DK93919098.9T patent/DK0656946T4/da active
- 1993-08-18 DK DK05008358.3T patent/DK1589107T3/da active
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011256169A (ja) * | 2002-11-08 | 2011-12-22 | Ablynx Nv | 治療用ポリペプチドの投与法およびそのためのポリペプチド |
JP2010518839A (ja) * | 2007-02-21 | 2010-06-03 | アブリンクス エン.ヴェー. | 血管内皮増殖因子に指向性を有するアミノ酸配列、及び過度の及び/もしくは病的な血管形成又は血管新生を特徴とする症状及び疾患を治療するためにこれを含むポリペプチド |
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