MX2017015046A - Anticuerpos anti-antigeno 4 del linfocito t citotoxico (ctla-4) y metodos para uso de los mismos. - Google Patents

Anticuerpos anti-antigeno 4 del linfocito t citotoxico (ctla-4) y metodos para uso de los mismos.

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Publication number
MX2017015046A
MX2017015046A MX2017015046A MX2017015046A MX2017015046A MX 2017015046 A MX2017015046 A MX 2017015046A MX 2017015046 A MX2017015046 A MX 2017015046A MX 2017015046 A MX2017015046 A MX 2017015046A MX 2017015046 A MX2017015046 A MX 2017015046A
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MX
Mexico
Prior art keywords
antibodies
ctla
methods
treating
subject
Prior art date
Application number
MX2017015046A
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English (en)
Inventor
Van Dijk Marc
Schaer David
Ritter Gerd
Merghoub Taha
David WOLCHOK Jedd
Anne Mundt Cornelia
Adam SAVITSKY David
Arthur Findeis Mark
Stuart Wilson Nicholas
Original Assignee
Agenus Inc
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Publication date
Application filed by Agenus Inc filed Critical Agenus Inc
Publication of MX2017015046A publication Critical patent/MX2017015046A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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Abstract

La presente descripción proporciona anticuerpos que enlazan específicamente a CTLA-4 y antagonizan la función de CTLA-4. Se proporcionan también composiciones farmacéuticas que comprenden estos anticuerpos, ácidos nucleicos que codifican estos anticuerpos, vectores de expresión y células hospederas para hacer estos anticuerpos, y métodos para tratar un sujeto que usa estos anticuerpos.
MX2017015046A 2015-05-29 2016-05-27 Anticuerpos anti-antigeno 4 del linfocito t citotoxico (ctla-4) y metodos para uso de los mismos. MX2017015046A (es)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201562168391P 2015-05-29 2015-05-29
US201562182363P 2015-06-19 2015-06-19
US201562190653P 2015-07-09 2015-07-09
US201562257202P 2015-11-18 2015-11-18
US201662280263P 2016-01-19 2016-01-19
US201662292500P 2016-02-08 2016-02-08
US201662294558P 2016-02-12 2016-02-12
US201662323226P 2016-04-15 2016-04-15
PCT/US2016/034508 WO2016196237A1 (en) 2015-05-29 2016-05-27 Anti-ctla-4 antibodies and methods of use thereof

Publications (1)

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MX2017015046A true MX2017015046A (es) 2018-05-17

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MX2017015046A MX2017015046A (es) 2015-05-29 2016-05-27 Anticuerpos anti-antigeno 4 del linfocito t citotoxico (ctla-4) y metodos para uso de los mismos.
MX2023000818A MX2023000818A (es) 2015-05-29 2017-11-23 Anticuerpos anti-antigeno 4 del linfocito t citotoxico (ctla-4) y metodos para uso de los mismos.

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EP (2) EP3736290A1 (es)
JP (2) JP6900323B2 (es)
KR (2) KR20230028478A (es)
CN (2) CN107849144B (es)
AU (3) AU2016271591A1 (es)
BR (1) BR112017025564B8 (es)
CA (1) CA2986765A1 (es)
CL (1) CL2017003023A1 (es)
CO (1) CO2017013398A2 (es)
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HK (1) HK1253250A1 (es)
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PE (1) PE20180672A1 (es)
PL (1) PL3303394T3 (es)
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SG10201913276WA (en) 2015-09-01 2020-02-27 Agenus Inc Anti-pd-1 antibodies and methods of use thereof
GEP20207174B (en) 2015-11-18 2020-11-10 Merck Sharp & Dohme Ctla4 binders
WO2017106638A1 (en) 2015-12-16 2017-06-22 Gritstone Oncology, Inc. Neoantigen identification, manufacture, and use
US11542332B2 (en) 2016-03-26 2023-01-03 Bioatla, Inc. Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof
CN109475602B (zh) 2016-06-20 2023-05-16 科马布有限公司 抗pd-l1和il-2细胞因子
CN107815467B (zh) 2016-08-31 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化基因改造动物模型的制备方法及应用
CN107815468B (zh) 2016-08-31 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化基因改造动物模型的制备方法及应用
WO2018041121A1 (en) 2016-08-31 2018-03-08 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric ctla-4
EP3532504A1 (en) 2016-10-28 2019-09-04 Bristol-Myers Squibb Company Methods of treating urothelial carcinoma using an anti-pd-1 antibody
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