SG10201913500TA - Anti-ctla-4 antibodies and methods of use thereof - Google Patents
Anti-ctla-4 antibodies and methods of use thereofInfo
- Publication number
- SG10201913500TA SG10201913500TA SG10201913500TA SG10201913500TA SG10201913500TA SG 10201913500T A SG10201913500T A SG 10201913500TA SG 10201913500T A SG10201913500T A SG 10201913500TA SG 10201913500T A SG10201913500T A SG 10201913500TA SG 10201913500T A SG10201913500T A SG 10201913500TA
- Authority
- SG
- Singapore
- Prior art keywords
- ctla
- antibodies
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562168391P | 2015-05-29 | 2015-05-29 | |
US201562182363P | 2015-06-19 | 2015-06-19 | |
US201562190653P | 2015-07-09 | 2015-07-09 | |
US201562257202P | 2015-11-18 | 2015-11-18 | |
US201662280263P | 2016-01-19 | 2016-01-19 | |
US201662292500P | 2016-02-08 | 2016-02-08 | |
US201662294558P | 2016-02-12 | 2016-02-12 | |
US201662323226P | 2016-04-15 | 2016-04-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201913500TA true SG10201913500TA (en) | 2020-03-30 |
Family
ID=56118035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201913500TA SG10201913500TA (en) | 2015-05-29 | 2016-05-27 | Anti-ctla-4 antibodies and methods of use thereof |
Country Status (26)
Country | Link |
---|---|
US (4) | US10144779B2 (en) |
EP (2) | EP3303394B1 (en) |
JP (2) | JP6900323B2 (en) |
KR (2) | KR102492532B1 (en) |
CN (2) | CN113603784A (en) |
AU (3) | AU2016271591A1 (en) |
BR (1) | BR112017025564B8 (en) |
CA (1) | CA2986765A1 (en) |
CL (1) | CL2017003023A1 (en) |
CO (1) | CO2017013398A2 (en) |
DK (1) | DK3303394T3 (en) |
ES (1) | ES2803655T3 (en) |
HK (1) | HK1253250A1 (en) |
HR (1) | HRP20201031T1 (en) |
HU (1) | HUE050750T2 (en) |
IL (2) | IL255468B (en) |
LT (1) | LT3303394T (en) |
MA (2) | MA44594B1 (en) |
MX (2) | MX2017015046A (en) |
PE (1) | PE20180672A1 (en) |
PL (1) | PL3303394T3 (en) |
PT (1) | PT3303394T (en) |
RS (1) | RS60792B1 (en) |
SG (1) | SG10201913500TA (en) |
SI (1) | SI3303394T1 (en) |
WO (1) | WO2016196237A1 (en) |
Families Citing this family (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL3303394T3 (en) | 2015-05-29 | 2020-11-16 | Agenus Inc. | Anti-ctla-4 antibodies and methods of use thereof |
BR112018003186A2 (en) | 2015-09-01 | 2018-09-25 | Agenus Inc. | anti-pd-1 antibodies and their methods of use |
JO3739B1 (en) | 2015-11-18 | 2021-01-31 | Merck Sharp & Dohme | Ctla4 binders |
PE20181535A1 (en) | 2015-12-16 | 2018-09-26 | Gritstone Oncology Inc | IDENTIFICATION, MANUFACTURE AND USE OF NEOANTIGEN |
US11542332B2 (en) | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
WO2017220989A1 (en) | 2016-06-20 | 2017-12-28 | Kymab Limited | Anti-pd-l1 and il-2 cytokines |
CN107815467B (en) | 2016-08-31 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | Preparation method and application of humanized gene modified animal model |
CN107815468B (en) | 2016-08-31 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | Preparation method and application of humanized gene modified animal model |
EP3532504A1 (en) | 2016-10-28 | 2019-09-04 | Bristol-Myers Squibb Company | Methods of treating urothelial carcinoma using an anti-pd-1 antibody |
CA3046082A1 (en) * | 2016-12-07 | 2018-06-14 | Agenus Inc. | Antibodies and methods of use thereof |
JP6992068B2 (en) | 2016-12-07 | 2022-02-03 | アジェナス インコーポレイテッド | Anti-CTLA-4 antibodies and how to use them |
KR20240023449A (en) | 2017-02-08 | 2024-02-21 | 드래곤플라이 쎄라퓨틱스, 인크. | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
TWI674261B (en) | 2017-02-17 | 2019-10-11 | 美商英能腫瘤免疫股份有限公司 | Nlrp3 modulators |
EP4273258A3 (en) | 2017-02-20 | 2024-01-17 | Dragonfly Therapeutics, Inc. | Proteins binding her2, nkg2d and cd16 |
US11319372B2 (en) * | 2017-02-21 | 2022-05-03 | Remd Biotherapeutics, Inc. | Cancer treatment using antibodies that bind cytotoxic T-lymphocyte antigen-4 (CTLA-4) |
MX2019009660A (en) * | 2017-02-28 | 2019-10-02 | Bristol Myers Squibb Co | Use of anti-ctla-4 antibodies with enhanced adcc to enhance immune response to a vaccine. |
SG10202110594UA (en) | 2017-03-31 | 2021-11-29 | Bristol Myers Squibb Co | Methods of treating tumor |
TWI788340B (en) | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | Anti-icos agonist antibodies and uses thereof |
CA3060618A1 (en) | 2017-05-19 | 2018-11-22 | Wuxi Biologics (Shanghai) Co. Ltd. | Novel monoclonal antibodies to cytotoxic t-lymphocyte-associated protein 4 (ctla-4) |
CN116478289A (en) * | 2017-05-19 | 2023-07-25 | 上海药明生物技术有限公司 | Novel CTLA-4 monoclonal antibody |
WO2018222711A2 (en) | 2017-05-30 | 2018-12-06 | Bristol-Myers Squibb Company | Compositions comprising a combination of an anti-lag-3 antibody, a pd-1 pathway inhibitor, and an immunotherapeutic agent |
KR20200028434A (en) | 2017-07-14 | 2020-03-16 | 인네이트 튜머 이뮤니티, 인코포레이티드 | NLRP3 modulator |
TWI799432B (en) * | 2017-07-27 | 2023-04-21 | 美商再生元醫藥公司 | Anti-ctla-4 antibodies and uses thereof |
EP3675843A4 (en) | 2017-08-31 | 2021-11-03 | IO Therapeutics, Inc. | Rar selective agonists in combination with immune modulators for cancer immunotherapy |
AU2017432728A1 (en) * | 2017-09-21 | 2020-02-27 | Eucure (Beijing) Biopharma Co. Ltd. | Anti-CTLA4 antibodies and uses thereof |
EP3694532A4 (en) | 2017-10-10 | 2021-07-14 | Gritstone Oncology, Inc. | Neoantigen identification using hotspots |
US20200239577A1 (en) | 2017-10-15 | 2020-07-30 | Bristol-Myers Squibb Company | Methods of treating tumor |
JP7201400B2 (en) | 2017-11-14 | 2023-01-10 | ファイザー・インク | EZH2 inhibitor combination therapy |
JP2021503897A (en) | 2017-11-22 | 2021-02-15 | グリットストーン オンコロジー インコーポレイテッド | Reduced junction epitope presentation for nascent antigens |
SG11202006823XA (en) | 2018-01-22 | 2020-08-28 | Bristol Myers Squibb Co | Compositions and methods of treating cancer |
JP2021512630A (en) | 2018-02-08 | 2021-05-20 | ドラゴンフライ セラピューティクス, インコーポレイテッド | Antibody variable domain targeting NKG2D receptor |
CN110272490B (en) * | 2018-03-14 | 2021-05-14 | 上海开拓者生物医药有限公司 | Targeted CTLA-4 antibody, preparation method and application thereof |
WO2019179388A1 (en) * | 2018-03-19 | 2019-09-26 | Wuxi Biologics (Shanghai) Co., Ltd. | Novel anti-ctla-4 antibody polypeptide |
US20210020264A1 (en) * | 2018-03-20 | 2021-01-21 | Cytomx Therapeutics, Inc. | Systems and methods for quantitative pharmacological modeling of activatable antibody species in mammalian subjects |
WO2019183551A1 (en) | 2018-03-23 | 2019-09-26 | Bristol-Myers Squibb Company | Antibodies against mica and/or micb and uses thereof |
EP3774911A1 (en) | 2018-03-30 | 2021-02-17 | Bristol-Myers Squibb Company | Methods of treating tumor |
KR20210005106A (en) | 2018-04-25 | 2021-01-13 | 인네이트 튜머 이뮤니티, 인코포레이티드 | NLRP3 regulator |
EA202091888A1 (en) * | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | VARIABLE ANTIBODY DOMAINS TARGETED ON THE NKG2D RECEPTOR |
US20210308123A1 (en) | 2018-08-16 | 2021-10-07 | Innate Tumor Immunity, Inc. | Nlrp3 modulators |
WO2020037092A1 (en) | 2018-08-16 | 2020-02-20 | Innate Tumor Immunity, Inc. | Imidazo[4,5-c]quinoline derived nlrp3-modulators |
BR112021002642A2 (en) | 2018-08-16 | 2021-05-04 | Innate Tumor Immunity, Inc. | substituted 4-amino-1h-imidazo[4,5-c]quinoline compounds and improved methods for their preparation |
WO2020058762A1 (en) * | 2018-09-20 | 2020-03-26 | Tikcro Technologies Ltd | Antibodies specific to ctla-4 and uses thereof |
EP3870609A1 (en) | 2018-10-23 | 2021-09-01 | Bristol-Myers Squibb Company | Methods of treating tumor |
NZ775959A (en) * | 2018-10-31 | 2022-08-26 | Bioatla Inc | Anti-ctla4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
KR20210093950A (en) | 2018-11-16 | 2021-07-28 | 네오이뮨텍, 인코퍼레이티드 | Methods of Treating Tumors with a Combination of IL-7 Protein and Immune Checkpoint Inhibitors |
TW202033555A (en) | 2018-11-16 | 2020-09-16 | 美商必治妥美雅史谷比公司 | Anti-nkg2a antibodies and uses thereof |
KR20210108978A (en) | 2018-12-21 | 2021-09-03 | 오제 이뮈노테라프틱스 | Bifunctional Anti-PD-1/IL-7 Molecules |
JP2022516881A (en) * | 2018-12-26 | 2022-03-03 | キシリオ ディベロップメント インコーポレイテッド | Anti-CTLA4 antibody and how to use it |
JP2022516071A (en) * | 2018-12-27 | 2022-02-24 | ギガジェン,インコーポレイティッド | Anti-CTLA-4 binding protein and how to use it |
MX2021007860A (en) | 2018-12-28 | 2021-10-26 | Transgene | M2-defective poxvirus. |
CN113301962A (en) | 2019-01-14 | 2021-08-24 | 先天肿瘤免疫公司 | Heterocyclic NLRP3 modulators for the treatment of cancer |
KR20210114983A (en) | 2019-01-14 | 2021-09-24 | 인네이트 튜머 이뮤니티, 인코포레이티드 | NLRP3 modulators |
EP3911641A1 (en) | 2019-01-14 | 2021-11-24 | Innate Tumor Immunity, Inc. | Nlrp3 modulators |
KR20210114456A (en) | 2019-01-14 | 2021-09-23 | 인네이트 튜머 이뮤니티, 인코포레이티드 | Substituted quinazolines as NLRP3-modulators for use in the treatment of cancer |
WO2020165374A1 (en) | 2019-02-14 | 2020-08-20 | Ose Immunotherapeutics | Bifunctional molecule comprising il-15ra |
CN113677402A (en) | 2019-03-28 | 2021-11-19 | 百时美施贵宝公司 | Method for treating tumors |
WO2020198676A1 (en) | 2019-03-28 | 2020-10-01 | Bristol-Myers Squibb Company | Methods of treating tumor |
SG11202112021QA (en) | 2019-05-08 | 2021-11-29 | Janssen Biotech Inc | Materials and methods for modulating t cell mediated immunity |
WO2020243568A1 (en) | 2019-05-30 | 2020-12-03 | Bristol-Myers Squibb Company | Methods of identifying a subject suitable for an immuno-oncology (i-o) therapy |
JP2022534981A (en) | 2019-05-30 | 2022-08-04 | ブリストル-マイヤーズ スクイブ カンパニー | Cellular localization signatures and combination treatments |
CN114174538A (en) | 2019-05-30 | 2022-03-11 | 百时美施贵宝公司 | Multiple tumor gene signatures suitable for immunooncology therapy |
WO2021041954A2 (en) * | 2019-08-28 | 2021-03-04 | The Research Foundation For The State University Of New York | Targeted delivery of tumor matrix modifying enzymes |
AU2020350795A1 (en) | 2019-09-22 | 2022-03-31 | Bristol-Myers Squibb Company | Quantitative spatial profiling for LAG-3 antagonist therapy |
WO2021092221A1 (en) | 2019-11-06 | 2021-05-14 | Bristol-Myers Squibb Company | Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy |
WO2021092220A1 (en) | 2019-11-06 | 2021-05-14 | Bristol-Myers Squibb Company | Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy |
MX2022005474A (en) | 2019-11-08 | 2022-06-02 | Bristol Myers Squibb Co | Lag-3 antagonist therapy for melanoma. |
TW202136287A (en) | 2019-12-17 | 2021-10-01 | 法商Ose免疫治療公司 | Bifunctional molecules comprising an il-7 variant |
WO2021127554A1 (en) | 2019-12-19 | 2021-06-24 | Bristol-Myers Squibb Company | Combinations of dgk inhibitors and checkpoint antagonists |
AU2019479791A1 (en) | 2019-12-27 | 2022-07-14 | Chugai Seiyaku Kabushiki Kaisha | Anti-CTLA-4 antibody and use thereof |
US20230348458A1 (en) | 2020-01-10 | 2023-11-02 | Innate Tumor Immunity, Inc. | Nlrp3 modulators |
JP2023514152A (en) | 2020-02-06 | 2023-04-05 | ブリストル-マイヤーズ スクイブ カンパニー | IL-10 and its uses |
WO2021216920A1 (en) | 2020-04-22 | 2021-10-28 | Iovance Biotherapeutics, Inc. | Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy |
KR20230058442A (en) | 2020-08-28 | 2023-05-03 | 브리스톨-마이어스 스큅 컴퍼니 | LAG-3 antagonist therapy for hepatocellular carcinoma |
WO2022047412A1 (en) | 2020-08-31 | 2022-03-03 | Bristol-Myers Squibb Company | Cell localization signature and immunotherapy |
JP2023548051A (en) | 2020-10-23 | 2023-11-15 | ブリストル-マイヤーズ スクイブ カンパニー | LAG-3 antagonist therapy for lung cancer |
UY39488A (en) * | 2020-10-28 | 2022-04-29 | Janssen Biotech Inc | COMPOSITIONS AND METHODS FOR MODULATING DELTA GAMMA CHAIN-MEDIATED IMMUNITY |
WO2022112198A1 (en) | 2020-11-24 | 2022-06-02 | Worldwide Innovative Network | Method to select the optimal immune checkpoint therapies |
WO2022120179A1 (en) | 2020-12-03 | 2022-06-09 | Bristol-Myers Squibb Company | Multi-tumor gene signatures and uses thereof |
US20220233689A1 (en) | 2020-12-28 | 2022-07-28 | Bristol-Myers Squibb Company | Methods of treating tumors |
AU2021411486A1 (en) | 2020-12-28 | 2023-06-29 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
WO2022212876A1 (en) | 2021-04-02 | 2022-10-06 | The Regents Of The University Of California | Antibodies against cleaved cdcp1 and uses thereof |
EP4320156A1 (en) | 2021-04-09 | 2024-02-14 | Ose Immunotherapeutics | Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains |
WO2022214653A1 (en) | 2021-04-09 | 2022-10-13 | Ose Immunotherapeutics | New scaffold for bifunctional molecules with improved properties |
AR126236A1 (en) | 2021-06-25 | 2023-10-04 | Chugai Pharmaceutical Co Ltd | USE OF THE ANTI-CTLA-4 ANTIBODY |
CN117616123A (en) | 2021-06-25 | 2024-02-27 | 中外制药株式会社 | anti-CTLA-4 antibodies |
WO2023077034A1 (en) | 2021-10-28 | 2023-05-04 | Lyell Immunopharma, Inc. | Methods for culturing immune cells |
CA3224890A1 (en) | 2021-10-29 | 2023-05-04 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for hematological cancer |
WO2023130081A1 (en) | 2021-12-30 | 2023-07-06 | Neoimmunetech, Inc. | Method of treating a tumor with a combination of il-7 protein and vegf antagonist |
CN114437220B (en) * | 2022-01-24 | 2023-04-14 | 广东医科大学 | anti-CTLA-4 nano antibody, encoding gene, recombinant nano antibody, recombinant vector, recombinant bacterium and application thereof |
WO2023147371A1 (en) | 2022-01-26 | 2023-08-03 | Bristol-Myers Squibb Company | Combination therapy for hepatocellular carcinoma |
WO2023164638A1 (en) | 2022-02-25 | 2023-08-31 | Bristol-Myers Squibb Company | Combination therapy for colorectal carcinoma |
WO2023168404A1 (en) | 2022-03-04 | 2023-09-07 | Bristol-Myers Squibb Company | Methods of treating a tumor |
WO2023170606A1 (en) | 2022-03-08 | 2023-09-14 | Alentis Therapeutics Ag | Use of anti-claudin-1 antibodies to increase t cell availability |
WO2023178329A1 (en) | 2022-03-18 | 2023-09-21 | Bristol-Myers Squibb Company | Methods of isolating polypeptides |
WO2023196987A1 (en) | 2022-04-07 | 2023-10-12 | Bristol-Myers Squibb Company | Methods of treating tumor |
WO2023213763A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Poxvirus encoding a binding agent comprising an anti- pd-l1 sdab |
WO2023213764A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf |
WO2023235847A1 (en) | 2022-06-02 | 2023-12-07 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
WO2024003353A1 (en) | 2022-07-01 | 2024-01-04 | Transgene | Fusion protein comprising a surfactant-protein-d and a member of the tnfsf |
CN115845039A (en) * | 2022-07-01 | 2023-03-28 | 可蓝赛生物医药(上海)有限公司 | Broad-spectrum polypeptide tumor vaccine composition |
WO2024003360A1 (en) | 2022-07-01 | 2024-01-04 | Institut Curie | Biomarkers and uses thereof for the treatment of neuroblastoma |
WO2024028386A1 (en) | 2022-08-02 | 2024-02-08 | Ose Immunotherapeutics | Multifunctional molecule directed against cd28 |
Family Cites Families (275)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4044126A (en) | 1972-04-20 | 1977-08-23 | Allen & Hanburys Limited | Steroidal aerosol compositions and process for the preparation thereof |
GB1429184A (en) | 1972-04-20 | 1976-03-24 | Allen & Hanburys Ltd | Physically anti-inflammatory steroids for use in aerosols |
US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
US4716111A (en) | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
EP0216846B2 (en) | 1985-04-01 | 1995-04-26 | Celltech Limited | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US5869620A (en) | 1986-09-02 | 1999-02-09 | Enzon, Inc. | Multivalent antigen-binding proteins |
GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
IL91501A (en) | 1988-09-02 | 1998-03-10 | Dyax Corp | Generation of a variegated library of mutant potential binding proteins and screening of said library for proteins with a desired binding activity |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5413923A (en) | 1989-07-25 | 1995-05-09 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
US5585112A (en) | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
US5780225A (en) | 1990-01-12 | 1998-07-14 | Stratagene | Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules |
AU7247191A (en) | 1990-01-11 | 1991-08-05 | Molecular Affinities Corporation | Production of antibodies using gene libraries |
US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
DE69133566T2 (en) | 1990-01-12 | 2007-12-06 | Amgen Fremont Inc. | Formation of xenogenic antibodies |
IT1246382B (en) | 1990-04-17 | 1994-11-18 | Eurand Int | METHOD FOR THE TARGETED AND CONTROLLED DELIVERY OF DRUGS IN THE INTESTINE AND PARTICULARLY IN THE COLON |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
DK0814159T3 (en) | 1990-08-29 | 2005-10-24 | Genpharm Int | Transgenic, non-human animals capable of forming heterologous antibodies |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
US5543390A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
WO1992009690A2 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
DK1471142T3 (en) | 1991-04-10 | 2009-03-09 | Scripps Research Inst | Heterodimeric receptor libraries using phagemids |
EP0519596B1 (en) | 1991-05-17 | 2005-02-23 | Merck & Co. Inc. | A method for reducing the immunogenicity of antibody variable domains |
JPH07503124A (en) | 1991-06-14 | 1995-04-06 | ゾーマ・コーポレーション | Antibody fragments and their complexes produced by microorganisms |
DE122004000008I1 (en) | 1991-06-14 | 2005-06-09 | Genentech Inc | Humanized heregulin antibody. |
US5851795A (en) | 1991-06-27 | 1998-12-22 | Bristol-Myers Squibb Company | Soluble CTLA4 molecules and uses thereof |
US5637481A (en) | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
ATE463573T1 (en) | 1991-12-02 | 2010-04-15 | Medimmune Ltd | PRODUCTION OF AUTOANTIBODIES ON PHAGE SURFACES BASED ON ANTIBODIES SEGMENT LIBRARIES |
CA2103887C (en) | 1991-12-13 | 2005-08-30 | Gary M. Studnicka | Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof |
GB9203459D0 (en) | 1992-02-19 | 1992-04-08 | Scotgen Ltd | Antibodies with germ-line variable regions |
US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
US6174666B1 (en) | 1992-03-27 | 2001-01-16 | The United States Of America As Represented By The Department Of Health And Human Services | Method of eliminating inhibitory/instability regions from mRNA |
US6010715A (en) | 1992-04-01 | 2000-01-04 | Bertek, Inc. | Transdermal patch incorporating a polymer film incorporated with an active agent |
US6024975A (en) | 1992-04-08 | 2000-02-15 | Americare International Diagnostics, Inc. | Method of transdermally administering high molecular weight drugs with a polymer skin enhancer |
US6005079A (en) | 1992-08-21 | 1999-12-21 | Vrije Universiteit Brussels | Immunoglobulins devoid of light chains |
PT1498427E (en) | 1992-08-21 | 2010-03-22 | Univ Bruxelles | Immunoglobulins devoid of light chains |
US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
EP0672142B1 (en) | 1992-12-04 | 2001-02-28 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
US6274552B1 (en) | 1993-03-18 | 2001-08-14 | Cytimmune Sciences, Inc. | Composition and method for delivery of biologically-active factors |
US5985307A (en) | 1993-04-14 | 1999-11-16 | Emory University | Device and method for non-occlusive localized drug delivery |
US5523092A (en) | 1993-04-14 | 1996-06-04 | Emory University | Device for local drug delivery and methods for using the same |
DK0698097T3 (en) | 1993-04-29 | 2001-10-08 | Unilever Nv | Production of antibodies or (functionalized) fragments thereof derived from Camelidae heavy chain immunoglobulins |
US6004534A (en) | 1993-07-23 | 1999-12-21 | Massachusetts Institute Of Technology | Targeted polymerized liposomes for improved drug delivery |
WO1995015982A2 (en) | 1993-12-08 | 1995-06-15 | Genzyme Corporation | Process for generating specific antibodies |
US5997873A (en) | 1994-01-13 | 1999-12-07 | Mount Sinai School Of Medicine Of The City University Of New York | Method of preparation of heat shock protein 70-peptide complexes |
ATE300610T1 (en) | 1994-01-31 | 2005-08-15 | Univ Boston | LIBRARIES OF POLYCLONAL ANTIBODIES |
US6719972B1 (en) | 1994-06-03 | 2004-04-13 | Repligen Corporation | Methods of inhibiting T cell proliferation or IL-2 accumulation with CTLA4- specific antibodies |
US5516637A (en) | 1994-06-10 | 1996-05-14 | Dade International Inc. | Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage |
US5759542A (en) | 1994-08-05 | 1998-06-02 | New England Deaconess Hospital Corporation | Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases |
US5660854A (en) | 1994-11-28 | 1997-08-26 | Haynes; Duncan H | Drug releasing surgical implant or dressing material |
US5983134A (en) | 1995-04-23 | 1999-11-09 | Electromagnetic Bracing Systems Inc. | Electrophoretic cuff apparatus drug delivery system |
EP0822830B1 (en) | 1995-04-27 | 2008-04-02 | Amgen Fremont Inc. | Human anti-IL-8 antibodies, derived from immunized xenomice |
AU2466895A (en) | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US6316652B1 (en) | 1995-06-06 | 2001-11-13 | Kosta Steliou | Drug mitochondrial targeting agents |
US5811097A (en) | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
US6167301A (en) | 1995-08-29 | 2000-12-26 | Flower; Ronald J. | Iontophoretic drug delivery device having high-efficiency DC-to-DC energy conversion circuit |
US5935576A (en) | 1995-09-13 | 1999-08-10 | Fordham University | Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens |
GB9601081D0 (en) | 1995-10-06 | 1996-03-20 | Cambridge Antibody Tech | Specific binding members for human transforming growth factor beta;materials and methods |
AU6873396A (en) | 1995-10-16 | 1997-05-07 | Unilever N.V. | A bifunctional or bivalent antibody fragment analogue |
US6039975A (en) | 1995-10-17 | 2000-03-21 | Hoffman-La Roche Inc. | Colon targeted delivery system |
JP2978435B2 (en) | 1996-01-24 | 1999-11-15 | チッソ株式会社 | Method for producing acryloxypropyl silane |
TW345603B (en) | 1996-05-29 | 1998-11-21 | Gmundner Fertigteile Gmbh | A noise control device for tracks |
US6027947A (en) | 1996-08-20 | 2000-02-22 | Ramtron International Corporation | Partially or completely encapsulated top electrode of a ferroelectric capacitor |
US5985317A (en) | 1996-09-06 | 1999-11-16 | Theratech, Inc. | Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents |
WO1998014179A1 (en) | 1996-10-01 | 1998-04-09 | Cima Labs Inc. | Taste-masked microcapsule compositions and methods of manufacture |
US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
US6131570A (en) | 1998-06-30 | 2000-10-17 | Aradigm Corporation | Temperature controlling device for aerosol drug delivery |
CA2722378C (en) | 1996-12-03 | 2015-02-03 | Amgen Fremont Inc. | Human antibodies that bind tnf.alpha. |
US20060034844A1 (en) | 1996-12-04 | 2006-02-16 | The Regents Of The University Of California | Stimulation of T cells against self antigens using CTLA-4 blocking agents |
US5860957A (en) | 1997-02-07 | 1999-01-19 | Sarcos, Inc. | Multipathway electronically-controlled drug delivery system |
US6017540A (en) | 1997-02-07 | 2000-01-25 | Fordham University | Prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases with heat shock/stress protein-peptide complexes |
WO1998042752A1 (en) | 1997-03-21 | 1998-10-01 | Brigham And Women's Hospital Inc. | Immunotherapeutic ctla-4 binding peptides |
US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
JP3876002B2 (en) | 1997-04-14 | 2007-01-31 | ミクロメート・アクチエンゲゼルシャフト | Novel methods for producing anti-human antigen receptors and their use |
US6060082A (en) | 1997-04-18 | 2000-05-09 | Massachusetts Institute Of Technology | Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery |
US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
US7951917B1 (en) | 1997-05-02 | 2011-05-31 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
US5948433A (en) | 1997-08-21 | 1999-09-07 | Bertek, Inc. | Transdermal patch |
EP0968711B9 (en) | 1997-10-28 | 2008-05-28 | Bando Chemical Industries, Ltd. | Dermatological patch sheet and process for producing base sheet therefor |
US5948646A (en) | 1997-12-11 | 1999-09-07 | Fordham University | Methods for preparation of vaccines against cancer comprising heat shock protein-peptide complexes |
CA2323746A1 (en) | 1998-03-19 | 1999-09-23 | Heska Corporation | T cell costimulatory proteins, sequences and uses thereof |
US6048736A (en) | 1998-04-29 | 2000-04-11 | Kosak; Kenneth M. | Cyclodextrin polymers for carrying and releasing drugs |
AU774962B2 (en) | 1998-12-03 | 2004-07-15 | Regents Of The University Of California, The | Stimulation of T cells against self antigens using CTLA-4 blocking agents |
US6682736B1 (en) | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
US6271359B1 (en) | 1999-04-14 | 2001-08-07 | Musc Foundation For Research Development | Tissue-specific and pathogen-specific toxic agents and ribozymes |
US6256533B1 (en) | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
WO2001014557A1 (en) | 1999-08-23 | 2001-03-01 | Dana-Farber Cancer Institute, Inc. | Pd-1, a receptor for b7-4, and uses therefor |
US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
ATE440111T1 (en) | 1999-11-29 | 2009-09-15 | Bac Ip B V | IMMOBILIZED ANTIGEN BINDING MOLECULES FROM A DOMAIN |
ES2629683T3 (en) | 1999-11-30 | 2017-08-14 | Mayo Foundation For Medical Education And Research | B7-H1, a new immunoregulatory molecule |
EP1261376A1 (en) | 2000-01-27 | 2002-12-04 | Genetics Institute, LLC | Antibodies against ctla4(cd152), conjugates comprising same, and uses thereof |
US6261595B1 (en) | 2000-02-29 | 2001-07-17 | Zars, Inc. | Transdermal drug patch with attached pocket for controlled heating device |
WO2001079300A1 (en) | 2000-04-12 | 2001-10-25 | Genetics Institute, Llc. | Surface-bound antigen binding portions of antibodies that bind to ctla-4 and cd28 and uses therefor |
ES2295228T3 (en) * | 2000-11-30 | 2008-04-16 | Medarex, Inc. | TRANSGROMIC TRANSCROMOSOMIC ROLLERS FOR THE PREPARATION OF HUMAN ANTIBODIES. |
IL149701A0 (en) * | 2001-05-23 | 2002-11-10 | Pfizer Prod Inc | Use of anti-ctla-4 antibodies |
WO2004006955A1 (en) | 2001-07-12 | 2004-01-22 | Jefferson Foote | Super humanized antibodies |
WO2003042402A2 (en) | 2001-11-13 | 2003-05-22 | Dana-Farber Cancer Institute, Inc. | Agents that modulate immune cell activation and methods of use thereof |
AUPS054702A0 (en) | 2002-02-14 | 2002-03-07 | Immunaid Pty Ltd | Cancer therapy |
US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
US20040014194A1 (en) | 2002-03-27 | 2004-01-22 | Schering Corporation | Beta-secretase crystals and methods for preparing and using the same |
NZ536420A (en) | 2002-04-12 | 2008-04-30 | Medarex Inc | Methods of treatment using CTLA-4 antibodies |
JP2005533015A (en) | 2002-05-02 | 2005-11-04 | ユニバーシティー オブ コネティカット ヘルス センター | Use of heat shock proteins to enhance the effectiveness of antibody therapy |
IL149820A0 (en) | 2002-05-23 | 2002-11-10 | Curetech Ltd | Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency |
DE10161767T1 (en) | 2002-07-03 | 2018-06-07 | Honjo Tasuku | Immunopotentiating compositions containing an anti-PD-L1 antibody |
EP1549678A4 (en) | 2002-09-30 | 2006-01-18 | Pfizer Prod Inc | Hybridomas producing high levels of human sequence antibody |
US7521051B2 (en) | 2002-12-23 | 2009-04-21 | Medimmune Limited | Methods of upmodulating adaptive immune response using anti-PD-1 antibodies |
US9068234B2 (en) | 2003-01-21 | 2015-06-30 | Ptc Therapeutics, Inc. | Methods and agents for screening for compounds capable of modulating gene expression |
US8388955B2 (en) | 2003-03-03 | 2013-03-05 | Xencor, Inc. | Fc variants |
US7465446B2 (en) | 2003-05-30 | 2008-12-16 | Medarex, Inc. | Surrogate therapeutic endpoint for anti-CTLA4-based immunotherapy of disease |
WO2005035575A2 (en) | 2003-08-22 | 2005-04-21 | Medimmune, Inc. | Humanization of antibodies |
EP1732600A2 (en) | 2004-03-26 | 2006-12-20 | Pfizer Products Incorporated | Uses of anti-ctla-4 antibodies |
US7494779B2 (en) | 2004-06-14 | 2009-02-24 | Li-Te Chin | Method for producing human antibodies to human CD152 with properties of agonist, antagonist, or inverse agonist |
US20060057626A1 (en) | 2004-09-03 | 2006-03-16 | Nichol Geoffrey M | Assessment of CTLA-4 polymorphisms in CTLA-4 blockade therapy |
US20090252741A1 (en) | 2004-09-08 | 2009-10-08 | Ohio State University Research Foundation | Human monoclonal anti-ctla4 antibodies in cancer treatment |
DE102004063494A1 (en) | 2004-12-23 | 2006-07-13 | Tegenero Ag | antibody |
WO2006096488A2 (en) | 2005-03-08 | 2006-09-14 | Pharmacia & Upjohn Company Llc | Composition comprising human igg2 antibody and chelating agent |
US20060240006A1 (en) * | 2005-04-20 | 2006-10-26 | Chishih Chu | Novel antibody structures derived from human germline sequences |
AU2006244885B2 (en) | 2005-05-09 | 2011-03-31 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics |
JP2006327937A (en) | 2005-05-23 | 2006-12-07 | Ritsutoku Kin | Human antibody structure equipped with human germ cell line gene structure and derived fragment of the same |
SI1907000T2 (en) | 2005-06-08 | 2020-07-31 | Dana-Farber Cancer Institute | Methods and compositions for the treatment of persistent HIV infections by inhibiting the programmed cell death 1 (PD-1) pathway |
HUE026039T2 (en) | 2005-07-01 | 2016-05-30 | Squibb & Sons Llc | Human monoclonal antibodies to programmed death ligand 1 (pd-l1) |
WO2007056539A2 (en) | 2005-11-08 | 2007-05-18 | Medarex, Inc. | Prophylaxis and treatment of enterocolitis associated with anti-ctla-4 antibody therapy |
CA2630157C (en) | 2005-12-07 | 2018-01-09 | Medarex, Inc. | Ctla-4 antibody dosage escalation regimens |
CN101822820A (en) | 2005-12-20 | 2010-09-08 | 布里斯托尔—迈尔斯斯奎布公司 | Stable protein formulations |
JP6092497B2 (en) | 2006-03-30 | 2017-03-08 | ユニバーシティー オブ カリフォルニア | Methods and compositions for localized secretion of anti-CTLA-4 antibodies |
US7919079B2 (en) | 2006-03-31 | 2011-04-05 | Biosante Pharmaceuticals, Inc. | Cancer immunotherapy compositions and methods of use |
EP2007423A2 (en) | 2006-04-05 | 2008-12-31 | Pfizer Products Incorporated | Ctla4 antibody combination therapy |
CN101074264B (en) | 2006-05-17 | 2011-08-17 | 上海抗体药物国家工程研究中心有限公司 | Recombinant anti-CTLA4 monoclonal antibody, its production and use |
WO2008071447A2 (en) | 2006-12-15 | 2008-06-19 | Ablynx N.V. | Amino acid sequences that modulate the interaction between cells of the immune system |
WO2008100562A2 (en) * | 2007-02-14 | 2008-08-21 | Medical College Of Georgia Research Institute, Inc. | Indoleamine 2,3-dioxygenase, pd-1/pd-l pathways, and ctla4 pathways in the activation of regulatory t cells |
US9244059B2 (en) | 2007-04-30 | 2016-01-26 | Immutep Parc Club Orsay | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
SI2170959T1 (en) | 2007-06-18 | 2014-04-30 | Merck Sharp & Dohme B.V. | Antibodies to human programmed death receptor pd-1 |
EP3124046B1 (en) | 2007-07-12 | 2019-12-25 | GITR, Inc. | Combination therapies employing gitr binding molecules |
PE20120259A1 (en) | 2007-08-09 | 2012-04-04 | Boehringer Ingelheim Int | ANTI-CD37 ANTIBODIES |
JP6035009B2 (en) | 2007-08-22 | 2016-11-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Activable binding polypeptides and methods for identification and use thereof |
US7968300B2 (en) | 2007-11-21 | 2011-06-28 | Li-Te Chin | Method of isolating regulatory T cells from human samples |
US8227577B2 (en) | 2007-12-21 | 2012-07-24 | Hoffman-La Roche Inc. | Bivalent, bispecific antibodies |
EP2227296B1 (en) | 2008-01-08 | 2015-11-25 | Bristol-Myers Squibb Company | Combination of anti-ctla4 antibody with tubulin modulating agents for the treatment of proliferative diseases |
WO2009100140A1 (en) | 2008-02-04 | 2009-08-13 | Medarex, Inc. | Anti-clta-4 antibodies with reduced blocking of binding of ctla-4 to b7 and uses thereof |
US8747847B2 (en) | 2008-02-11 | 2014-06-10 | Curetech Ltd. | Monoclonal antibodies for tumor treatment |
EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | Pd-1 binding proteins |
DK2824100T3 (en) | 2008-07-08 | 2018-04-16 | Incyte Holdings Corp | 1,2,5-oxadiazoles as inhibitors of indolamine-2,3-dioxygenase |
US8119129B2 (en) | 2008-08-01 | 2012-02-21 | Bristol-Myers Squibb Company | Combination of anti-CTLA4 antibody with dasatinib for the treatment of proliferative diseases |
AR072999A1 (en) | 2008-08-11 | 2010-10-06 | Medarex Inc | HUMAN ANTIBODIES THAT JOIN GEN 3 OF LYMPHOCYTARY ACTIVATION (LAG-3) AND THE USES OF THESE |
PE20110435A1 (en) | 2008-08-25 | 2011-07-20 | Amplimmune Inc | ANTAGONIST COMPOSITIONS OF PD-1 |
AU2009290544B2 (en) | 2008-09-12 | 2015-07-16 | Oxford University Innovation Limited | PD-1 specific antibodies and uses thereof |
KR102097887B1 (en) | 2008-09-26 | 2020-04-06 | 다나-파버 캔서 인스티튜트 인크. | Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses therefor |
CN114835812A (en) | 2008-12-09 | 2022-08-02 | 霍夫曼-拉罗奇有限公司 | anti-PD-L1 antibodies and their use for enhancing T cell function |
JP5851842B2 (en) | 2009-01-12 | 2016-02-03 | サイトムエックス セラピューティクス, インク.CytomX Therapeutics, Inc. | Modified antibody composition and methods of making and using the same |
GB0903325D0 (en) | 2009-02-26 | 2009-04-08 | Univ Aberdeen | Antibody molecules |
KR101747103B1 (en) | 2009-06-26 | 2017-06-14 | 리제너론 파마슈티칼스 인코포레이티드 | Readily isolated bispecific antibodies with native immunoglobulin format |
JP5589077B2 (en) * | 2009-07-20 | 2014-09-10 | ブリストル−マイヤーズ スクイブ カンパニー | Combination of anti-CTLA4 antibody and various therapeutic regimens for synergistic treatment of proliferative diseases |
JP5883384B2 (en) | 2009-08-13 | 2016-03-15 | ザ ジョンズ ホプキンス ユニバーシティー | How to regulate immune function |
AU2010308030B2 (en) | 2009-10-12 | 2014-05-29 | Pfizer Inc. | Cancer treatment |
GB0920258D0 (en) | 2009-11-19 | 2010-01-06 | Alligator Bioscience Ab | New medical agents and use thereof |
HUE037159T2 (en) | 2009-11-24 | 2018-08-28 | Medimmune Ltd | Targeted binding agents against b7-h1 |
CN102134276A (en) | 2010-01-22 | 2011-07-27 | 上海抗体药物国家工程研究中心有限公司 | Chimeric antibody resisting CTLA-4 (Cytotoxic T Lymphocyte Antigen) |
WO2011100841A1 (en) | 2010-02-16 | 2011-08-25 | Valorisation-Recherche, Limited Partnership | Pd-1 modulation and uses thereof for modulating hiv replication |
WO2011110604A1 (en) | 2010-03-11 | 2011-09-15 | Ucb Pharma, S.A. | Pd-1 antibody |
CA2794708C (en) | 2010-03-29 | 2021-11-16 | Zymeworks Inc. | Antibodies with enhanced or suppressed effector function |
GB201103955D0 (en) | 2011-03-09 | 2011-04-20 | Antitope Ltd | Antibodies |
RU2625034C2 (en) | 2011-04-20 | 2017-07-11 | МЕДИММЬЮН, ЭлЭлСи | Antibodies and other molecules binding b7-h1 and pd-1 |
JP2014517846A (en) * | 2011-05-25 | 2014-07-24 | メルク・シャープ・アンド・ドーム・コーポレーション | Process for producing Fc-containing polypeptides having improved properties |
EP2723381A4 (en) | 2011-06-21 | 2015-03-18 | Univ Johns Hopkins | Focused radiation for augmenting immune-based therapies against neoplasms |
LT2734551T (en) | 2011-07-24 | 2018-04-10 | Cure Tech Ltd. | Variants of humanized immunomodulatory monoclonal antibodies |
EP3939613A1 (en) | 2011-08-11 | 2022-01-19 | ONO Pharmaceutical Co., Ltd. | Therapeutic agent for autoimmune diseases comprising pd-1 agonist |
US8920075B2 (en) | 2011-09-01 | 2014-12-30 | Halo Maritime Defense Systems, Inc. | Marine barrier and gate |
US20130071403A1 (en) | 2011-09-20 | 2013-03-21 | Vical Incorporated | Synergistic anti-tumor efficacy using alloantigen combination immunotherapy |
AU2012344260B2 (en) | 2011-11-28 | 2017-09-07 | Merck Patent Gmbh | Anti-PD-L1 antibodies and uses thereof |
CA2865153C (en) | 2012-02-23 | 2022-11-22 | Sloan-Kettering Institute For Cancer Research | Prediction of responsiveness to treatment with immunomodulatory therapeutics and method of monitoring abscopal effects during such treatment |
US20150079100A1 (en) | 2012-03-23 | 2015-03-19 | Bristol-Myers Squibb Company | Methods of treatments using ctla-4 antibodies |
MX359257B (en) | 2012-05-04 | 2018-09-19 | Pfizer | Prostate-associated antigens and vaccine-based immunotherapy regimens. |
WO2013169388A1 (en) | 2012-05-08 | 2013-11-14 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Predictive biomarkers for ctla-4 blockade therapy and for pd-1 blockade therapy |
SG11201407190TA (en) | 2012-05-15 | 2014-12-30 | Bristol Myers Squibb Co | Cancer immunotherapy by disrupting pd-1/pd-l1 signaling |
CN115093480A (en) | 2012-05-31 | 2022-09-23 | 索伦托药业有限公司 | Antigen binding proteins that bind to PD-L1 |
WO2013192546A1 (en) | 2012-06-22 | 2013-12-27 | Cytomx Therapeutics, Inc. | Activatable antibodies having non-binding steric moieties and mehtods of using the same |
KR20150037857A (en) | 2012-06-22 | 2015-04-08 | 싸이톰스 테라퓨틱스, 인크. | Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof |
AR091649A1 (en) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | OPTIMIZATION OF ANTIBODIES THAT FIX THE LYMPHOCYTE ACTIVATION GEN 3 (LAG-3) AND ITS USES |
CN111499755A (en) | 2012-08-03 | 2020-08-07 | 丹娜法伯癌症研究院 | anti-PD-L1 and PD-L2 double-binding antibody single reagents and methods of use thereof |
CN107892719B (en) | 2012-10-04 | 2022-01-14 | 达纳-法伯癌症研究所公司 | Human monoclonal anti-PD-L1 antibodies and methods of use |
WO2014066532A1 (en) | 2012-10-23 | 2014-05-01 | Bristol-Myers Squibb Company | Combination of anti-kir and anti-ctla-4 antibodies to treat cancer |
EP2911669B1 (en) | 2012-10-26 | 2024-04-10 | The University of Chicago | Synergistic combination of immunologic inhibitors for the treatment of cancer |
AR093984A1 (en) | 2012-12-21 | 2015-07-01 | Merck Sharp & Dohme | ANTIBODIES THAT JOIN LEGEND 1 OF SCHEDULED DEATH (PD-L1) HUMAN |
JP6605957B2 (en) | 2013-01-04 | 2019-11-13 | シトムクス セラピューティクス,インコーポレイティド | Compositions and methods for detecting protease activity in biological systems |
ME03796B (en) | 2013-03-15 | 2021-04-20 | Glaxosmithkline Ip Dev Ltd | Anti-lag-3 binding proteins |
ES2699599T3 (en) | 2013-03-15 | 2019-02-11 | Abbvie Biotherapeutics Inc | Fc variants |
EP2992086B1 (en) | 2013-04-30 | 2020-09-30 | La Jolla Institute for Allergy and Immunology | Modulation of regulatory t cell function via protein kinase c-eta |
US9815897B2 (en) | 2013-05-02 | 2017-11-14 | Anaptysbio, Inc. | Antibodies directed against programmed death-1 (PD-1) |
CN105683217B (en) | 2013-05-31 | 2019-12-10 | 索伦托治疗有限公司 | Antigen binding proteins that bind to PD-1 |
WO2014209804A1 (en) | 2013-06-24 | 2014-12-31 | Biomed Valley Discoveries, Inc. | Bispecific antibodies |
CN104250302B (en) | 2013-06-26 | 2017-11-14 | 上海君实生物医药科技股份有限公司 | The anti-antibody of PD 1 and its application |
BR112016000853A2 (en) | 2013-07-16 | 2017-12-12 | Genentech Inc | methods for treating or delaying, reducing or inhibiting cancer relapse or progression and the progression of an immune-related disease in an individual, to increase, improve or stimulate an immune response or function in an individual and kit. |
WO2015016718A1 (en) | 2013-08-02 | 2015-02-05 | Bionovion Holding B.V. | Combining cd27 agonists and immune checkpoint inhibition for immune stimulation |
WO2015024042A1 (en) | 2013-08-22 | 2015-02-26 | The Council Of The Queensland Institute Of Medical Research | Immunoreceptor modulation for treating cancer and viral infections |
WO2015035112A1 (en) | 2013-09-05 | 2015-03-12 | The Johns Hopkins University | Cancer therapy via a combination of epigenetic modulation and immune modulation |
US10077305B2 (en) | 2013-09-10 | 2018-09-18 | Medimmune Limited | Antibodies against PD-1 and uses thereof |
CN112552401B (en) | 2013-09-13 | 2023-08-25 | 广州百济神州生物制药有限公司 | anti-PD 1 antibodies and their use as therapeutic and diagnostic agents |
SG11201601763SA (en) | 2013-09-20 | 2016-04-28 | Bristol Myers Squibb Co | Combination of anti-lag-3 antibodies and anti-pd-1 antibodies to treat tumors |
EP3757130A1 (en) | 2013-09-26 | 2020-12-30 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
US9968674B2 (en) | 2013-10-18 | 2018-05-15 | Regeneron Pharmaceuticals, Inc. | Methods and compositions comprising a combination of a VEGF Trap and an anti-CTLA-4 antibody |
US10202454B2 (en) | 2013-10-25 | 2019-02-12 | Dana-Farber Cancer Institute, Inc. | Anti-PD-L1 monoclonal antibodies and fragments thereof |
CN104558177B (en) | 2013-10-25 | 2020-02-18 | 苏州思坦维生物技术股份有限公司 | Monoclonal antibody for antagonizing and inhibiting programmed death receptor PD-1and ligand combination thereof, and coding sequence and application thereof |
WO2015069770A1 (en) | 2013-11-05 | 2015-05-14 | Cognate Bioservices, Inc. | Combinations of checkpoint inhibitors and therapeutics to treat cancer |
DK3081576T3 (en) | 2013-12-12 | 2019-10-21 | Shanghai hengrui pharmaceutical co ltd | PD-1 ANTIBODY, ANTI-BINDING FRAGMENT THEREOF AND MEDICAL USE THEREOF |
DK3094351T3 (en) | 2014-01-15 | 2022-02-21 | Kadmon Corp Llc | IMMUNE MODULATORY AGENTS |
TWI680138B (en) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | Human antibodies to pd-l1 |
PL3556775T3 (en) | 2014-01-28 | 2022-01-31 | Bristol-Myers Squibb Company | Anti-lag-3 antibodies to treat hematological malignancies |
US9676863B2 (en) | 2014-02-10 | 2017-06-13 | Merck Patent Gmbh | Targeted TGFβ inhibitors |
WO2015134605A1 (en) | 2014-03-05 | 2015-09-11 | Bristol-Myers Squibb Company | Treatment of renal cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent |
KR102442436B1 (en) | 2014-03-14 | 2022-09-15 | 노파르티스 아게 | Antibody molecules to lag-3 and uses thereof |
WO2015153820A1 (en) | 2014-04-02 | 2015-10-08 | Felder Mitchell S | Ctla-4 blockade with metronomic chemotherapy for the treatment of cancer |
WO2015176033A1 (en) | 2014-05-15 | 2015-11-19 | Bristol-Myers Squibb Company | Treatment of lung cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent |
EP3149042B1 (en) | 2014-05-29 | 2019-08-28 | Spring Bioscience Corporation | Pd-l1 antibodies and uses thereof |
WO2015195163A1 (en) | 2014-06-20 | 2015-12-23 | R-Pharm Overseas, Inc. | Pd-l1 antagonist fully human antibody |
TWI693232B (en) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | Covalently bonded diabodies having immunoreactivity with pd-1 and lag-3, and methods of use thereof |
CN110156892B (en) | 2014-07-03 | 2023-05-16 | 百济神州有限公司 | anti-PD-L1 antibodies and their use as therapeutic and diagnostic agents |
HUE045108T2 (en) | 2014-07-16 | 2019-12-30 | Transgene Sa | Oncolytic virus for expression of immune checkpoint modulators |
CN105330740B (en) | 2014-07-30 | 2018-08-17 | 珠海市丽珠单抗生物技术有限公司 | Anti- PD-1 antibody and its application |
CN105296433B (en) | 2014-08-01 | 2018-02-09 | 中山康方生物医药有限公司 | A kind of CTLA4 antibody, its medical composition and its use |
ES2847311T3 (en) | 2014-08-05 | 2021-08-02 | MabQuest SA | Immunological reagents that bind to PD-1 |
JO3663B1 (en) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | Anti-lag3 antibodies and antigen-binding fragments |
WO2016030455A1 (en) | 2014-08-28 | 2016-03-03 | Medimmune Limited | Anti-b7-h1 and anti-ctla-4 antibodies for treating non-small lung cancer |
BR112016030670A2 (en) | 2014-08-29 | 2017-10-31 | Hoffmann La Roche | "immunocytokine" |
US11344620B2 (en) | 2014-09-13 | 2022-05-31 | Novartis Ag | Combination therapies |
WO2016054555A2 (en) | 2014-10-03 | 2016-04-07 | Novartis Ag | Combination therapies |
AU2015333687B2 (en) | 2014-10-14 | 2021-03-18 | Dana-Farber Cancer Institute, Inc. | Antibody molecules to PD-L1 and uses thereof |
US20190076452A1 (en) | 2014-11-11 | 2019-03-14 | Medimmune Limited | Therapeutic combinations for treating neoplasia |
KR20230030022A (en) | 2014-11-13 | 2023-03-03 | 더 존스 홉킨스 유니버시티 | Checkpoint blockade and microsatellite instability |
BR112017010101A2 (en) | 2014-12-16 | 2018-01-02 | Bristol Myers Squibb Co | use of immune system checkpoint inhibitors in central nervous system neoplasms |
EP3233918A1 (en) | 2014-12-19 | 2017-10-25 | Novartis AG | Combination therapies |
JP6797803B2 (en) | 2014-12-31 | 2020-12-09 | セルジーン コーポレイション | How to use natural killer cells to treat blood disorders, solid tumors, or infectious diseases |
WO2016130986A1 (en) | 2015-02-13 | 2016-08-18 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind ctla4 |
WO2016149387A1 (en) | 2015-03-18 | 2016-09-22 | The Johns Hopkins University | Androgen deprivation with immune checkpoint blockade delays the development of castration resistant prostate cancer |
US20180094058A1 (en) | 2015-04-17 | 2018-04-05 | Bioxcel Corporation | Compositions and methods for preventing tumor growth and treating cancer by targeting lectin galactoside-binding soluble 3 binding protein |
US20180134771A1 (en) | 2015-05-07 | 2018-05-17 | Bioxcel Corporation | Novel immunomodulatory therapeutic strategies targeting tumors in cancer |
WO2016183469A1 (en) | 2015-05-13 | 2016-11-17 | Robert Kirken | Anti-ctla-4 blockade |
US20160347848A1 (en) | 2015-05-28 | 2016-12-01 | Medimmune Limited | Therapeutic combinations and methods for treating neoplasia |
PL3303394T3 (en) | 2015-05-29 | 2020-11-16 | Agenus Inc. | Anti-ctla-4 antibodies and methods of use thereof |
WO2016196389A1 (en) | 2015-05-29 | 2016-12-08 | Bristol-Myers Squibb Company | Treatment of renal cell carcinoma |
WO2016197067A1 (en) | 2015-06-05 | 2016-12-08 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Gm-csf/cd40l vaccine and checkpoint inhibitor combination therapy |
JP2018522887A (en) | 2015-07-14 | 2018-08-16 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Cancer treatment using immune checkpoint inhibitors |
EP3331917A1 (en) | 2015-08-04 | 2018-06-13 | GlaxoSmithKline Intellectual Property Development Limited | Combination treatments and uses and methods thereof |
US20180230431A1 (en) | 2015-08-07 | 2018-08-16 | Glaxosmithkline Intellectual Property Development Limited | Combination Therapy |
WO2017062615A2 (en) | 2015-10-08 | 2017-04-13 | Macrogenics, Inc. | Combination therapy for the treatment of cancer |
WO2017079303A1 (en) | 2015-11-02 | 2017-05-11 | The Cleveland Clinic Foundation | Sequentially orchestrated immune checkpoint therapy for the treatment and prevention of cancer |
BR112018012113A2 (en) | 2015-12-15 | 2018-12-04 | Oncoimmune Inc | chimeric and humanized anti-human ctla4 monoclonal antibodies and uses thereof |
TWI808934B (en) | 2015-12-31 | 2023-07-21 | 美商伯克利之光生命科技公司 | Tumor infilitrating cells engineered to express a pro-inflammatory polypeptide |
MA43587A (en) | 2016-01-10 | 2018-11-14 | Modernatx Inc | THERAPEUTIC RNA CODING FOR ANTI-CTLA-4 ANTIBODIES |
EP3407911B1 (en) | 2016-01-28 | 2022-05-18 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods and pharmaceutical composition for the treatment of cancer |
US20170233476A1 (en) | 2016-02-12 | 2017-08-17 | Sorrento Therapeutics, Inc. | Antibody Therapeutics That Bind CTLA4 |
EP3213768A1 (en) | 2016-03-01 | 2017-09-06 | LODOCO CLINICAL Kft | Combination of low dose immune checkpoint blockade with high dose il-2 for treating metastatic cancer |
EP3423087B1 (en) | 2016-03-04 | 2023-11-15 | IO Biotech APS | Combination therapy against cancer |
EP3426271A4 (en) | 2016-03-10 | 2019-10-16 | Cold Genesys, Inc. | Methods of treating solid or lymphatic tumors by combination therapy |
WO2017160717A2 (en) | 2016-03-15 | 2017-09-21 | Memorial Sloan Kettering Cancer Center | Method of treating diseases using kinase modulators |
SG10201603721TA (en) | 2016-05-10 | 2017-12-28 | Agency Science Tech & Res | Anti-CTLA-4 Antibodies |
CN107400166A (en) | 2016-05-19 | 2017-11-28 | 苏州康宁杰瑞生物科技有限公司 | for CTLA4 single domain antibody and its derived protein |
WO2017201502A1 (en) | 2016-05-20 | 2017-11-23 | Biohaven Pharmaceutical Holding Company Ltd. | Use of glutamate modulating agents with immunotherapies to treat cancer |
CA3046082A1 (en) * | 2016-12-07 | 2018-06-14 | Agenus Inc. | Antibodies and methods of use thereof |
JP6992068B2 (en) * | 2016-12-07 | 2022-02-03 | アジェナス インコーポレイテッド | Anti-CTLA-4 antibodies and how to use them |
-
2016
- 2016-05-27 PL PL16728509T patent/PL3303394T3/en unknown
- 2016-05-27 KR KR1020177037545A patent/KR102492532B1/en active IP Right Grant
- 2016-05-27 WO PCT/US2016/034508 patent/WO2016196237A1/en active Application Filing
- 2016-05-27 CN CN202111057251.XA patent/CN113603784A/en active Pending
- 2016-05-27 MX MX2017015046A patent/MX2017015046A/en unknown
- 2016-05-27 AU AU2016271591A patent/AU2016271591A1/en not_active Abandoned
- 2016-05-27 BR BR112017025564A patent/BR112017025564B8/en active IP Right Grant
- 2016-05-27 HU HUE16728509A patent/HUE050750T2/en unknown
- 2016-05-27 US US15/166,305 patent/US10144779B2/en active Active
- 2016-05-27 EP EP16728509.7A patent/EP3303394B1/en active Active
- 2016-05-27 PT PT167285097T patent/PT3303394T/en unknown
- 2016-05-27 RS RS20200805A patent/RS60792B1/en unknown
- 2016-05-27 DK DK16728509.7T patent/DK3303394T3/en active
- 2016-05-27 EP EP20168222.6A patent/EP3736290A1/en active Pending
- 2016-05-27 MA MA44594A patent/MA44594B1/en unknown
- 2016-05-27 PE PE2017002485A patent/PE20180672A1/en unknown
- 2016-05-27 JP JP2017561965A patent/JP6900323B2/en active Active
- 2016-05-27 ES ES16728509T patent/ES2803655T3/en active Active
- 2016-05-27 KR KR1020237002568A patent/KR20230028478A/en not_active Application Discontinuation
- 2016-05-27 CA CA2986765A patent/CA2986765A1/en active Pending
- 2016-05-27 SI SI201630827T patent/SI3303394T1/en unknown
- 2016-05-27 CN CN201680042887.8A patent/CN107849144B/en active Active
- 2016-05-27 LT LTEP16728509.7T patent/LT3303394T/en unknown
- 2016-05-27 MA MA053355A patent/MA53355A/en unknown
- 2016-05-27 SG SG10201913500TA patent/SG10201913500TA/en unknown
-
2017
- 2017-11-06 IL IL255468A patent/IL255468B/en unknown
- 2017-11-23 MX MX2023000818A patent/MX2023000818A/en unknown
- 2017-11-28 CL CL2017003023A patent/CL2017003023A1/en unknown
- 2017-12-26 CO CONC2017/0013398A patent/CO2017013398A2/en unknown
-
2018
- 2018-09-29 HK HK18112539.3A patent/HK1253250A1/en unknown
- 2018-10-19 US US16/165,833 patent/US10479833B2/en active Active
-
2019
- 2019-06-28 AU AU2019204586A patent/AU2019204586C1/en active Active
-
2020
- 2020-04-24 US US16/858,195 patent/US11267889B2/en active Active
- 2020-06-30 HR HRP20201031TT patent/HRP20201031T1/en unknown
-
2021
- 2021-06-16 JP JP2021100134A patent/JP7456976B2/en active Active
- 2021-08-03 AU AU2021211991A patent/AU2021211991A1/en active Pending
-
2022
- 2022-01-24 US US17/582,839 patent/US20220267443A1/en active Pending
- 2022-03-27 IL IL291711A patent/IL291711A/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL291711A (en) | Anti-ctla-4 antibodies and methods of use thereof | |
IL282962A (en) | Anti-pd-1 antibodies and methods of use thereof | |
IL266918A (en) | Anti-ctla-4 antibodies and methods of use thereof | |
HK1249445A1 (en) | Anti-sortilin antibodies and methods of use thereof | |
IL259495A (en) | Antibodies and methods of use thereof | |
HK1252698A1 (en) | Anti-siglec-9 antibodies and methods of use thereof | |
HK1252696A1 (en) | Anti-siglec-7 antibodies and methods of use thereof | |
SG10201912150TA (en) | Anti-trem2 antibodies and methods of use thereof | |
IL270793A (en) | Anti-htra1 antibodies and methods of use thereof |