MX2016009010A - Anticuerpos anti-gen de activacion de linfocitos (lag-3) para tratar neoplasias hematologicas. - Google Patents

Anticuerpos anti-gen de activacion de linfocitos (lag-3) para tratar neoplasias hematologicas.

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Publication number
MX2016009010A
MX2016009010A MX2016009010A MX2016009010A MX2016009010A MX 2016009010 A MX2016009010 A MX 2016009010A MX 2016009010 A MX2016009010 A MX 2016009010A MX 2016009010 A MX2016009010 A MX 2016009010A MX 2016009010 A MX2016009010 A MX 2016009010A
Authority
MX
Mexico
Prior art keywords
lag
antibodies
hematological malignancies
treat hematological
lymphocytic leukemia
Prior art date
Application number
MX2016009010A
Other languages
English (en)
Inventor
Selby Mark
E Lewis Katherine
Grosso Joseph
A Gutierrez Andres
Mark HILL Christopher
Original Assignee
Bristol Myers Squibb Co
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Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2016009010A publication Critical patent/MX2016009010A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención proporciona métodos para el tratamiento clínico de las neoplasias hematológicas, tales como la leucemia linfocítica crónica recidivante o refractaria o el linfoma utilizando un anticuerpo anti-LAG-3. Las neoplasias particulares incluyen, por ejemplo, la leucemia linfocítica crónica (CLL), el linfoma de Hodgkin (HL), o el linfoma no de Hodgkin (NHL).
MX2016009010A 2014-01-28 2015-01-26 Anticuerpos anti-gen de activacion de linfocitos (lag-3) para tratar neoplasias hematologicas. MX2016009010A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461932589P 2014-01-28 2014-01-28
PCT/US2015/012916 WO2015116539A1 (en) 2014-01-28 2015-01-26 Anti-lag-3 antibodies to treat hematological malignancies

Publications (1)

Publication Number Publication Date
MX2016009010A true MX2016009010A (es) 2017-01-18

Family

ID=52478072

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016009010A MX2016009010A (es) 2014-01-28 2015-01-26 Anticuerpos anti-gen de activacion de linfocitos (lag-3) para tratar neoplasias hematologicas.
MX2022007800A MX2022007800A (es) 2014-01-28 2016-07-08 Anticuerpos anti-gen de activacion de linfocitos gen-3 (lag-3) para usarse en el tratamiento de neoplasias hematologicas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022007800A MX2022007800A (es) 2014-01-28 2016-07-08 Anticuerpos anti-gen de activacion de linfocitos gen-3 (lag-3) para usarse en el tratamiento de neoplasias hematologicas.

Country Status (20)

Country Link
US (4) US20160326248A1 (es)
EP (3) EP3099716A1 (es)
JP (3) JP2017505773A (es)
KR (2) KR20220147714A (es)
CN (1) CN105992595A (es)
BR (1) BR112016017174A2 (es)
CA (1) CA2937503A1 (es)
CY (1) CY1124977T1 (es)
DK (1) DK3556775T3 (es)
EA (1) EA201691361A1 (es)
ES (1) ES2902369T3 (es)
HR (1) HRP20212033T1 (es)
HU (1) HUE057817T2 (es)
LT (1) LT3556775T (es)
MX (2) MX2016009010A (es)
PL (1) PL3556775T3 (es)
PT (1) PT3556775T (es)
RS (1) RS62788B1 (es)
SI (1) SI3556775T1 (es)
WO (1) WO2015116539A1 (es)

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