BR112021012066A2 - Novas moléculas de ácido nucleico conjugadas e seus usos - Google Patents
Novas moléculas de ácido nucleico conjugadas e seus usosInfo
- Publication number
- BR112021012066A2 BR112021012066A2 BR112021012066A BR112021012066A BR112021012066A2 BR 112021012066 A2 BR112021012066 A2 BR 112021012066A2 BR 112021012066 A BR112021012066 A BR 112021012066A BR 112021012066 A BR112021012066 A BR 112021012066A BR 112021012066 A2 BR112021012066 A2 BR 112021012066A2
- Authority
- BR
- Brazil
- Prior art keywords
- nucleic acid
- acid molecules
- conjugated nucleic
- new conjugated
- new
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/345—Spatial arrangement of the modifications having at least two different backbone modifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
novas moléculas de ácido nucleico conjugadas e seus usos. a presente invenção diz respeito a novas moléculas de ácido nucleico de interesse terapêutico, em particular para uso no tratamento de câncer.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18306829 | 2018-12-21 | ||
EP18306826 | 2018-12-21 | ||
EP19202837 | 2019-10-11 | ||
EP19202834 | 2019-10-11 | ||
PCT/EP2019/086672 WO2020127965A1 (en) | 2018-12-21 | 2019-12-20 | New conjugated nucleic acid molecules and their uses |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021012066A2 true BR112021012066A2 (pt) | 2021-11-03 |
Family
ID=69005729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021012066A BR112021012066A2 (pt) | 2018-12-21 | 2019-12-20 | Novas moléculas de ácido nucleico conjugadas e seus usos |
Country Status (11)
Country | Link |
---|---|
US (1) | US20220054524A1 (pt) |
EP (1) | EP3898974A1 (pt) |
JP (2) | JP7450622B2 (pt) |
KR (1) | KR20210109564A (pt) |
CN (1) | CN113166762A (pt) |
AU (1) | AU2019408408A1 (pt) |
BR (1) | BR112021012066A2 (pt) |
CA (1) | CA3118182A1 (pt) |
IL (1) | IL282838A (pt) |
MX (1) | MX2021007271A (pt) |
WO (1) | WO2020127965A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20200407720A1 (en) * | 2018-03-13 | 2020-12-31 | Onxeo | A dbait molecule against acquired resistance in the treatment of cancer |
WO2023111203A1 (en) | 2021-12-16 | 2023-06-22 | Onxeo | New conjugated nucleic acid molecules and their uses |
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2019
- 2019-12-20 EP EP19827746.9A patent/EP3898974A1/en active Pending
- 2019-12-20 US US17/414,342 patent/US20220054524A1/en active Pending
- 2019-12-20 KR KR1020217023171A patent/KR20210109564A/ko unknown
- 2019-12-20 MX MX2021007271A patent/MX2021007271A/es unknown
- 2019-12-20 JP JP2021534234A patent/JP7450622B2/ja active Active
- 2019-12-20 CN CN201980082033.6A patent/CN113166762A/zh active Pending
- 2019-12-20 BR BR112021012066A patent/BR112021012066A2/pt unknown
- 2019-12-20 WO PCT/EP2019/086672 patent/WO2020127965A1/en unknown
- 2019-12-20 AU AU2019408408A patent/AU2019408408A1/en active Pending
- 2019-12-20 CA CA3118182A patent/CA3118182A1/en active Pending
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2021
- 2021-05-02 IL IL282838A patent/IL282838A/en unknown
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2024
- 2024-02-29 JP JP2024029960A patent/JP2024054419A/ja active Pending
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JP7450622B2 (ja) | 2024-03-15 |
MX2021007271A (es) | 2021-07-15 |
IL282838A (en) | 2021-06-30 |
EP3898974A1 (en) | 2021-10-27 |
AU2019408408A1 (en) | 2021-06-03 |
WO2020127965A1 (en) | 2020-06-25 |
KR20210109564A (ko) | 2021-09-06 |
JP2024054419A (ja) | 2024-04-16 |
CA3118182A1 (en) | 2020-06-25 |
JP2022514259A (ja) | 2022-02-10 |
CN113166762A (zh) | 2021-07-23 |
US20220054524A1 (en) | 2022-02-24 |
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