BR112017010761A2 - tratamento de doenças associadas à ativação de célula estrelada hepática com o uso de terapias de redução de amônia - Google Patents

tratamento de doenças associadas à ativação de célula estrelada hepática com o uso de terapias de redução de amônia

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Publication number
BR112017010761A2
BR112017010761A2 BR112017010761-9A BR112017010761A BR112017010761A2 BR 112017010761 A2 BR112017010761 A2 BR 112017010761A2 BR 112017010761 A BR112017010761 A BR 112017010761A BR 112017010761 A2 BR112017010761 A2 BR 112017010761A2
Authority
BR
Brazil
Prior art keywords
treatment
hepatic stellate
stellate cell
cell activation
diseases associated
Prior art date
Application number
BR112017010761-9A
Other languages
English (en)
Other versions
BR112017010761B1 (pt
Inventor
Jalan Rajiv
Prosad MOOKERJEE Rajeshwar
Rombouts Krista
Andreola Fausto
DE CHIARA Francesco
Louise Thomsen Karen
Original Assignee
Ucl Business Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucl Business Plc filed Critical Ucl Business Plc
Publication of BR112017010761A2 publication Critical patent/BR112017010761A2/pt
Publication of BR112017010761B1 publication Critical patent/BR112017010761B1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

são revelados no presente documento métodos para prevenir, tratar e atrasar o início ou a progressão de doenças associadas às células estreladas hepáticas (hscs), tal como doença hepática gordurosa não alcóolica (nafld), fibrose e câncer hepático, com o uso de terapias de redução de amônia.
BR112017010761-9A 2014-11-24 2015-11-23 Tratamento de doenças associadas à ativação de célula estrelada hepática com o uso de terapias de redução de amônia BR112017010761B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462083814P 2014-11-24 2014-11-24
US62/083,814 2014-11-24
PCT/US2015/062223 WO2016085887A1 (en) 2014-11-24 2015-11-23 Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies

Publications (2)

Publication Number Publication Date
BR112017010761A2 true BR112017010761A2 (pt) 2018-01-09
BR112017010761B1 BR112017010761B1 (pt) 2022-10-18

Family

ID=56074936

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017010761-9A BR112017010761B1 (pt) 2014-11-24 2015-11-23 Tratamento de doenças associadas à ativação de célula estrelada hepática com o uso de terapias de redução de amônia

Country Status (18)

Country Link
US (3) US10039735B2 (pt)
EP (2) EP3223829B1 (pt)
JP (2) JP6797117B2 (pt)
KR (2) KR20230018526A (pt)
CN (2) CN113633777A (pt)
AU (2) AU2015353703B2 (pt)
BR (1) BR112017010761B1 (pt)
CA (1) CA2968544A1 (pt)
DK (1) DK3223829T3 (pt)
EA (1) EA201790913A1 (pt)
ES (1) ES2769000T3 (pt)
HK (1) HK1243651A1 (pt)
IL (2) IL281349B (pt)
MX (2) MX2017006685A (pt)
NZ (1) NZ732632A (pt)
SG (1) SG11201704011XA (pt)
WO (1) WO2016085887A1 (pt)
ZA (1) ZA201703779B (pt)

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DK3223829T3 (da) 2020-02-10
IL252405A0 (en) 2017-07-31
EP3223829A1 (en) 2017-10-04
EP3685841A1 (en) 2020-07-29
CN107206021B (zh) 2021-09-03
CN113633777A (zh) 2021-11-12
EP3223829A4 (en) 2018-04-25
AU2015353703B2 (en) 2021-04-01
KR102487376B1 (ko) 2023-01-10
JP6797117B2 (ja) 2020-12-09
KR20170095894A (ko) 2017-08-23
AU2021203938A1 (en) 2021-07-08
US11040021B2 (en) 2021-06-22
CA2968544A1 (en) 2016-06-02
AU2015353703A1 (en) 2017-06-15
US20190070142A1 (en) 2019-03-07
US20200206175A1 (en) 2020-07-02
EP3223829B1 (en) 2019-10-23
US20170354627A1 (en) 2017-12-14
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JP7199400B2 (ja) 2023-01-05
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WO2016085887A1 (en) 2016-06-02
JP2020169180A (ja) 2020-10-15
JP2017535575A (ja) 2017-11-30
ES2769000T3 (es) 2020-06-24
ZA201703779B (en) 2021-10-27
IL281349A (en) 2021-04-29
KR20230018526A (ko) 2023-02-07
MX2020010194A (es) 2020-10-20
IL252405B (en) 2021-03-25
US10525029B2 (en) 2020-01-07
CN107206021A (zh) 2017-09-26
SG11201704011XA (en) 2017-06-29
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MX2017006685A (es) 2018-01-15
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