JPWO2007077995A1 - 筋肉増量剤 - Google Patents
筋肉増量剤 Download PDFInfo
- Publication number
- JPWO2007077995A1 JPWO2007077995A1 JP2007553004A JP2007553004A JPWO2007077995A1 JP WO2007077995 A1 JPWO2007077995 A1 JP WO2007077995A1 JP 2007553004 A JP2007553004 A JP 2007553004A JP 2007553004 A JP2007553004 A JP 2007553004A JP WO2007077995 A1 JPWO2007077995 A1 JP WO2007077995A1
- Authority
- JP
- Japan
- Prior art keywords
- muscle
- ornithine
- exercise
- salt
- bulking agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
Description
しかしながら、健常人がレジスタンス運動等の特別な運動を行わないことを想定した状況下において、オルニチンを摂取することにより筋肉量が増加することは知られていない。
(1)オルニチンまたはその塩を有効成分として含有し、レジスタンス運動による運動負荷をかけることなく筋肉量を増加させることを特徴とする筋肉増量剤。
(2)筋肉が骨格筋である上記(1)の剤。
(3)オルニチンまたはその塩の有効量を、必要とする対象に投与することを含む、レジスタンス運動による運動負荷をかけることなく筋肉量を増加させる方法。
(4)筋肉が骨格筋である上記(3)の方法。
(5)レジスタンス運動による運動負荷をかけることなく筋肉量を増加させることを特徴とする筋肉増量剤の製造のための、オルニチンまたはその塩の使用。
(6)筋肉が骨格筋である上記(5)の使用。
オルニチンは、化学的に合成する方法、発酵生産する方法等により取得することができる。また、オルニチンは、市販品を購入することにより取得することもできる。
L-オルニチンを化学的に合成する方法としては、例えば、Coll.Czechoslov.Chem.Commun.,24,1993(1959)に記載の方法があげられる。
また、L-オルニチンおよびD-オルニチンは、シグマ−アルドリッチ社等より購入することもできる。
オルニチンの塩としては、酸付加塩、金属塩、アンモニウム塩、有機アミン付加塩、アミノ酸付加塩等があげられる。
金属塩としては、ナトリウム塩、カリウム塩等のアルカリ金属塩、マグネシウム塩、カルシウム塩等のアルカリ土類金属塩、アルミニウム塩、亜鉛塩等があげられる。
有機アミン付加塩としては、モルホリン、ピペリジン等の塩があげられる。
アミノ酸付加塩としては、グリシン、フェニルアラニン、リジン、アスパラギン酸、グルタミン酸等の塩があげられる。
本発明の筋肉増量剤には、オルニチンまたはその塩に加え、適宜、各用途に適した添加剤を含有させることができる。
本発明の筋肉増量剤を投与することにより、レジスタンス運動による運動負荷をかけることなく、ヒトまたは非ヒト動物の筋肉量を増加させることができる。
製剤は、有効成分としてオルニチンまたはその塩を含有するが、更に任意の有効成分を含有していてもよい。また、それら製剤は、有効成分を薬理学的に許容される一種またはそれ以上の担体と一緒に混合し、製剤学の技術分野においてよく知られている任意の方法により製造される。
投与期間は、特に限定されないが、通常は1日間〜1年間、好ましくは1週間〜3ヶ月間である。
投与期間は、特に限定されないが、通常は1日間〜1年間、好ましくは1週間〜3ヶ月間である。
試験例
被験動物として、12週齢のSD系雌ラット(Slc株式会社より購入)を11頭用いた。
予備飼育終了後、ラットを2群に分け、6頭には第1表に示した対照飼料を与え、残りの5頭には第1表に示したオルニチン塩酸塩(協和発酵工業株式会社製)を含有する飼料(オルニチン飼料)を与え、21日間飼育した。
(1)体重
体重は、飼育期間中の1-5日おきに測定した。飼育開始日および終了日の結果を第2表に示す。
(2)筋湿重量
被験筋には、ラット後肢下腿に位置する足底筋および腓腹筋の2つの筋を用いた。足底筋および腓腹筋は隣り合って存在しており、分離せずに摘出して重量を測定した。
飼育終了日において、体重測定後のラットを屠殺し、左右両後肢下腿の足底筋および腓腹筋を速やかに摘出した。生理食塩水で洗浄した後、余分な結合組織および腱、神経等を除去してから足底筋および腓腹筋の筋湿重量を測定した。
以上の結果から、健常人がレジスタンス運動等の特別な運動を行わないことを想定した状況下における、オルニチンの筋肉増量効果が明らかとなった。
以下に、本発明の実施例を示す。
オルニチンを含有する錠剤を、常法により製造する。すなわち、下記の各成分を均一に混合し、この混合物を単発式打錠機にて打錠し、直径5mm、重量15mgの錠剤を得る。
実施例1で得られる錠剤を粉砕、製粒し、篩別して20−50メッシュの顆粒剤を得る。
オルニチンを含有するドリンク剤を、下記の各成分を均一に攪拌溶解し、精製水を加えて全量を1000mlとすることにより製造する。なお、下記成分中の適量とは、香料、色素に関しては、通常の飲料の製造に用いられる量であり、精製水に関しては、他の成分に加え、全量として1000mlにするために必要な量のことをいう。
オルニチンを含有する錠剤を、常法により製造する。すなわち、下記の各成分を均一に混合し、この混合物をロータリー圧縮成型機にて成型し、直径8mm、重量250mgの錠剤を製造した。
実施例4で調製した混合物20kgと0.2kgの二酸化ケイ素とを混合攪拌して得られた混合物をカプセル充填機に投入し、ゼラチン製2号ハードカプセル20000錠に充填し、ハードカプセルを得た。得られたハードカプセルの表面をツェイン溶液を用いてコーティングし、オルニチン塩酸塩を含む腸溶カプセル20000錠を製造した。
実施例4で調製した錠剤の表面をシェラック溶液を用いてコーティングし、腸溶錠剤を製造した。
オルニチンを含有するドリンク剤を、下記の各成分を均一に攪拌溶解することにより製造した。
Claims (6)
- オルニチンまたはその塩を有効成分として含有し、レジスタンス運動による運動負荷をかけることなく筋肉量を増加させることを特徴とする筋肉増量剤。
- 筋肉が骨格筋である請求項1記載の剤。
- オルニチンまたはその塩の有効量を、必要とする対象に投与することを含む、レジスタンス運動による運動負荷をかけることなく筋肉量を増加させる方法。
- 筋肉が骨格筋である請求項3記載の方法。
- レジスタンス運動による運動負荷をかけることなく筋肉量を増加させることを特徴とする筋肉増量剤の製造のための、オルニチンまたはその塩の使用。
- 筋肉が骨格筋である請求項5記載の使用。
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US20120157526A1 (en) | 2009-06-08 | 2012-06-21 | Ucl Business Plc | Treatment of portal hypertension and restoration of liver function using l-ornithine phenylacetate |
KR20230018526A (ko) | 2014-11-24 | 2023-02-07 | 유씨엘 비즈니스 리미티드 | 암모니아-저감 치료를 이용한 간성상세포 활성화와 연관된 질병의 치료 |
JP6990170B2 (ja) * | 2015-08-18 | 2022-01-12 | オセラ セラピューティクス, インコーポレイテッド | L-オルニチンをフェニルアセテートおよびフェニルブチレートのうちの少なくとも1つと組み合わせて用いる筋肉喪失の治療および予防 |
JP2018090504A (ja) * | 2016-11-30 | 2018-06-14 | 株式会社東洋新薬 | 筋肉増強用組成物 |
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WO1998044793A1 (en) * | 1997-04-08 | 1998-10-15 | Albion Laboratories, Inc. | Non-steroidal anabolic composition |
JP2004256513A (ja) * | 2003-02-04 | 2004-09-16 | Ezaki Glico Co Ltd | 筋肉量増加剤 |
JP2005501061A (ja) * | 2001-08-10 | 2005-01-13 | ミレニアム バイオテクノロジーズ,インコーポレーテッド | 免疫機能損傷患者の為の栄養療法 |
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US20050176827A1 (en) * | 2002-05-10 | 2005-08-11 | Lee Steve S. | Compositions and methods for glycogen synthesis |
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WO1998044793A1 (en) * | 1997-04-08 | 1998-10-15 | Albion Laboratories, Inc. | Non-steroidal anabolic composition |
JP2005501061A (ja) * | 2001-08-10 | 2005-01-13 | ミレニアム バイオテクノロジーズ,インコーポレーテッド | 免疫機能損傷患者の為の栄養療法 |
JP2004256513A (ja) * | 2003-02-04 | 2004-09-16 | Ezaki Glico Co Ltd | 筋肉量増加剤 |
Non-Patent Citations (2)
Title |
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臨床スポーツ医学, vol. 22, no. 7, JPN6012043493, 2005, pages 793 - 798, ISSN: 0002308929 * |
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