JP6533784B2 - 眼の疲れ改善剤 - Google Patents
眼の疲れ改善剤 Download PDFInfo
- Publication number
- JP6533784B2 JP6533784B2 JP2016529667A JP2016529667A JP6533784B2 JP 6533784 B2 JP6533784 B2 JP 6533784B2 JP 2016529667 A JP2016529667 A JP 2016529667A JP 2016529667 A JP2016529667 A JP 2016529667A JP 6533784 B2 JP6533784 B2 JP 6533784B2
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- Prior art keywords
- citrulline
- eye fatigue
- fatigue
- group
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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Description
(1)シトルリンまたはその塩を有効成分として含有する眼の疲れの予防または改善剤。
(2)眼の疲れが、眼疲労である(1)記載の予防または改善剤。
(3)眼疲労が、運動後の眼の疲れ又は運動後の視野のかすみである、(2)記載の予防または改善剤。
(4)シトルリンまたはその塩の有効量を必要とする対象者に摂取させる工程を含む、眼の疲れの予防または改善方法。
(5)シトルリンまたはその塩の有効量を必要とする対象者に摂取させる工程を含む、眼の疲れの予防または改善方法(但し、ヒトに対する医療行為を除く)。
(6)眼の疲れが、眼疲労である(4)または(5)記載の方法。
(7)眼疲労が、運動後の眼の疲れ又は運動後の視野のかすみである、(6)記載の方法。
アンモニウム塩としては、例えばアンモニウム、テトラメチルアンモニウム等の塩があげられる。
有機アミン付加塩としては、例えばモルホリン、ピペリジン等の塩があげられる。
本発明の眼の疲れの予防または改善剤としては、シトルリンまたはその塩をそのまま投与することも可能であるが、通常各種の製剤として提供するのが好ましい。
製剤の投与形態は、経口投与または、例えば静脈内、腹膜内もしくは皮下投与等の非経口投与をあげることができるが、経口投与が好ましい。
摂取または投与期間は、特に限定されないが、通常は1日間〜1年間、好ましくは1週間〜3ヶ月間であり、さらに好ましくは、4〜8週間である。
眼疲労とは、上述したように、適当な休息で改善する生理的な疲労であり、テレビやパソコンの長時間使用等により眼を酷使した際又は運動した際に、ピント調節に働く毛様体筋に筋肉疲労と緊張が生じ、一過性の近視状態(視界がぼやける)、眼がチカチカする、まぶしい、眼が重い等の症状が起きることをいい、一般に眼の疲れを感じる状態をいう。
本発明の眼の疲れの予防または改善剤は、上記のような眼疲労を予防または改善することができる。
試験例1
健常な25歳から49歳までの女性47名を16名、15名および16名の3群に分け、1日1回、下記記載の所要量のカプセルを水と共に噛まずに摂取させ、8週間摂取させた。
A群:プラセボ食品8カプセル(プラセボ)
B群:L−シトルリン含有食品2カプセルおよびプラセボ食品6カプセル(8カプセル中L−シトルリンは合計400mg)
C群:L−シトルリン含有食品8カプセル(8カプセル中L−シトルリンは合計1600mg)
L−シトルリン含有食品1カプセル当たりの成分はシトルリン200mgおよびコーンスターチ200mgであり、プラセボ食品1カプセルの成分は、コーンスターチ330mgである。摂取開始4週間後および摂取開始8週間後の測定当日は来院時に摂取し、それ以外は各被験者が朝食後に摂取した。朝食後に摂取出来なかった場合は、その日のうちに摂取した。有効性評価にあたり、試験開始4週間後に来院しなかったA群の1名を除外し、A群15名、B群15名、C群16名について解析を行った。
その結果、シトルリン1600mg摂取により、試験開始8週間後の眼の疲れ、具体的には眼疲労の自覚症状が顕著な改善を示した。以上の結果から、シトルリン摂取により、眼の疲れが改善することが示された。
健常な20〜30代男性22人にL−シトルリン含有食品9カプセル(L−シトルリン 2400mg)もしくはプラセボ食品9カプセルを1日1回、水とともに8日間摂取させた。
試験食の摂取は8日間の摂取期間後に3週間のウォッシュアウト期間を設けてクロスオーバーで実施した。
L−シトルリン含有食品1カプセル当たりの成分はシトルリン267mgおよびコーンスターチ133mgであり、プラセボ食品1カプセルの成分は、コーンスターチ330mgである。測定当日(摂取8日目)は来院時に摂取し、それ以外は各被験者が就寝前に摂取した。
その結果、一日当り、シトルリン2400mgを8日間摂取することにより、運動後の眼の疲れ及び視野のかすみ、具体的には眼疲労の自覚症状が顕著な改善を示した。以上の結果から、シトルリン摂取により、眼の疲れが改善することが示された。
以下に、本発明の実施例を示す。
シトルリンを含有する錠剤の製造
L−シトルリン(協和発酵バイオ社製)120kg、環状オリゴ糖19kg、セルロース57kgおよびプルラン1kgを流動層造粒乾燥機で造粒した。得られた造粒物およびステアリン酸カルシウム3kgをコニカルブレンダーで混合した後、ロータリー圧縮成形機で圧縮成形して錠剤を製造した。
シトルリンを含有する腸溶錠剤の製造
実施例1で製造した錠剤の表面をシェラック溶液でコーティングして腸溶錠剤を製造した。
シトルリンを含有する腸溶カプセルの製造
L−シトルリン(協和発酵バイオ社製)120kg、環状オリゴ糖19kg、セルロース57kg、ステアリン酸カルシウム3kgおよびプルラン1kgを、コニカルブレンダーで混合した。得られる混合物20kgおよび0.2kgの二酸化ケイ素を混合撹拌して得られた混合物をカプセル充填機に投入し、ハードカプセルに充填してハードカプセルを得た。得られるハードカプセルの表面をツェイン溶液でコーティングして腸溶カプセルを製造した。
シトルリンを含有する飲料の製造
L−シトルリン(協和発酵バイオ社製)1.28kg、エリスリトール3kg、クエン酸0.05kg、人工甘味料3gおよび香料0.06kgを液温70℃で水50Lに撹拌溶解し、クエン酸でpHを3.3に調整後、プレート殺菌を用いて滅菌して瓶に充填後、パストライザー殺菌し、飲料を製造した。
Claims (3)
- シトルリンまたはその塩を有効成分として含有する眼の疲れの予防または改善剤。
- 眼の疲れが、眼疲労である請求項1記載の予防または改善剤。
- 眼疲労が、運動後の眼の疲れ又は運動後の視野のかすみである、請求項2記載の予防または改善剤。
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