SG11201704011XA - Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies - Google Patents

Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies

Info

Publication number
SG11201704011XA
SG11201704011XA SG11201704011XA SG11201704011XA SG11201704011XA SG 11201704011X A SG11201704011X A SG 11201704011XA SG 11201704011X A SG11201704011X A SG 11201704011XA SG 11201704011X A SG11201704011X A SG 11201704011XA SG 11201704011X A SG11201704011X A SG 11201704011XA
Authority
SG
Singapore
Prior art keywords
ammonia
treatment
cell activation
diseases associated
hepatic stellate
Prior art date
Application number
SG11201704011XA
Inventor
Rajiv Jalan
Rajeshwar Prosad Mookerjee
Krista Rombouts
Fausto Andreola
Chiara Francesco De
Karen Louise Thomsen
Original Assignee
Ucl Business Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucl Business Plc filed Critical Ucl Business Plc
Publication of SG11201704011XA publication Critical patent/SG11201704011XA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
SG11201704011XA 2014-11-24 2015-11-23 Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies SG11201704011XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462083814P 2014-11-24 2014-11-24
PCT/US2015/062223 WO2016085887A1 (en) 2014-11-24 2015-11-23 Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies

Publications (1)

Publication Number Publication Date
SG11201704011XA true SG11201704011XA (en) 2017-06-29

Family

ID=56074936

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201704011XA SG11201704011XA (en) 2014-11-24 2015-11-23 Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies

Country Status (18)

Country Link
US (3) US10039735B2 (en)
EP (2) EP3685841A1 (en)
JP (2) JP6797117B2 (en)
KR (2) KR20230018526A (en)
CN (2) CN107206021B (en)
AU (2) AU2015353703B2 (en)
BR (1) BR112017010761B1 (en)
CA (1) CA2968544A1 (en)
DK (1) DK3223829T3 (en)
EA (1) EA201790913A1 (en)
ES (1) ES2769000T3 (en)
HK (1) HK1243651A1 (en)
IL (2) IL281349B (en)
MX (2) MX2017006685A (en)
NZ (1) NZ732632A (en)
SG (1) SG11201704011XA (en)
WO (1) WO2016085887A1 (en)
ZA (1) ZA201703779B (en)

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WO2017031131A1 (en) 2015-08-18 2017-02-23 Ocera Therapeutics, Inc. Treatment and prevention of muscle loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate
US11219611B2 (en) 2015-11-13 2022-01-11 Ocera Therapeutics, Inc. Formulations of L-ornithine phenylacetate
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WO2018170234A1 (en) * 2017-03-15 2018-09-20 President And Fellows Of Harvard College Methods and compositions for treating cancer
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CN111295187A (en) 2017-08-14 2020-06-16 胺细拉健康公司 Amino acid composition for treating liver diseases
TWI636788B (en) * 2017-08-28 2018-10-01 長庚生物科技股份有限公司 Use of parabacteroides goldsteinii to treat fatty liver disease
EP3810123A1 (en) 2018-06-20 2021-04-28 Axcella Health Inc. Compositions and methods for the treatment of fat infiltration in muscle
KR102101342B1 (en) * 2018-09-14 2020-04-17 재단법인 대구경북첨단의료산업진흥재단 Pharmaceutical composition for prevention or treatment of non-alcoholic steatohepatitis containing tazemetostat or derivative thereof as an active ingredient
WO2023223520A1 (en) * 2022-05-19 2023-11-23 Ｉｓｍ株式会社 Screening system for deactivation inducer for activated hepatic stellate cells

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Also Published As

Publication number Publication date
US20190070142A1 (en) 2019-03-07
JP2017535575A (en) 2017-11-30
ES2769000T3 (en) 2020-06-24
NZ732632A (en) 2021-07-30
US10525029B2 (en) 2020-01-07
CA2968544A1 (en) 2016-06-02
CN113633777A (en) 2021-11-12
KR20170095894A (en) 2017-08-23
EP3223829A4 (en) 2018-04-25
AU2021203938A1 (en) 2021-07-08
DK3223829T3 (en) 2020-02-10
BR112017010761A2 (en) 2018-01-09
KR20230018526A (en) 2023-02-07
MX2020010194A (en) 2020-10-20
IL281349A (en) 2021-04-29
US10039735B2 (en) 2018-08-07
HK1243651A1 (en) 2018-07-20
CN107206021A (en) 2017-09-26
EP3685841A1 (en) 2020-07-29
US20200206175A1 (en) 2020-07-02
EP3223829A1 (en) 2017-10-04
BR112017010761B1 (en) 2022-10-18
KR102487376B1 (en) 2023-01-10
EA201790913A1 (en) 2017-11-30
JP6797117B2 (en) 2020-12-09
EP3223829B1 (en) 2019-10-23
US20170354627A1 (en) 2017-12-14
US11040021B2 (en) 2021-06-22
IL252405B (en) 2021-03-25
CN107206021B (en) 2021-09-03
AU2015353703A1 (en) 2017-06-15
ZA201703779B (en) 2021-10-27
IL252405A0 (en) 2017-07-31
WO2016085887A1 (en) 2016-06-02
IL281349B (en) 2022-09-01
JP2020169180A (en) 2020-10-15
MX2017006685A (en) 2018-01-15
JP7199400B2 (en) 2023-01-05
AU2015353703B2 (en) 2021-04-01

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