GB1067742A - Process for the preparation of l-ornithine l-aspartate - Google Patents
Process for the preparation of l-ornithine l-aspartateInfo
- Publication number
- GB1067742A GB1067742A GB3640563A GB3640563A GB1067742A GB 1067742 A GB1067742 A GB 1067742A GB 3640563 A GB3640563 A GB 3640563A GB 3640563 A GB3640563 A GB 3640563A GB 1067742 A GB1067742 A GB 1067742A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ornithine
- aspartate
- solvent
- volume
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Crystalline L-ornithine L-aspartate monohydrate is prepared by adding to an aqueous solution of L-ornithine L-aspartate a water-miscible organic solvent which is a non-solvent for L-ornithine L-aspartate, a volume of non-solvent of at least one-fifth, based on the volume of the solution, being added initially and, after the addition of seed crystals, a further volume of at least one-fifth being added at a rate such that at least 30 hours would be required to add the same volume of non-solvent as of the original solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3640563A GB1067742A (en) | 1963-09-16 | 1963-09-16 | Process for the preparation of l-ornithine l-aspartate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3640563A GB1067742A (en) | 1963-09-16 | 1963-09-16 | Process for the preparation of l-ornithine l-aspartate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1067742A true GB1067742A (en) | 1967-05-03 |
Family
ID=10387837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3640563A Expired GB1067742A (en) | 1963-09-16 | 1963-09-16 | Process for the preparation of l-ornithine l-aspartate |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1067742A (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4447366A (en) * | 1980-12-04 | 1984-05-08 | Morelle Jean V | Derivatives of lysine and aspartic acid |
| EP0477991A1 (en) * | 1990-09-28 | 1992-04-01 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing crystals of salt of acidic amino acid and basic amino acid |
| US8173706B2 (en) | 2009-04-03 | 2012-05-08 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| CN102827017A (en) * | 2011-06-14 | 2012-12-19 | 上海励睿化学科技有限公司 | Crystal form of double salt compound and preparation method thereof |
| US8389576B2 (en) | 2004-11-26 | 2013-03-05 | Ucl Business Plc | Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy |
| US8946473B2 (en) | 2010-10-06 | 2015-02-03 | Ocera Therapeutics, Inc. | Methods of making L-ornithine phenyl acetate |
| US10039735B2 (en) | 2014-11-24 | 2018-08-07 | Ucl Business Plc | Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies |
| US10835506B2 (en) | 2015-08-18 | 2020-11-17 | Ocera Therapeutics, Inc. | Treatment and prevention of muscle loss using L-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
| US11066352B2 (en) | 2017-05-11 | 2021-07-20 | Ocera Therapeutics, Inc. | Processes of making L-ornithine phenylacetate |
| US11266620B2 (en) | 2009-06-08 | 2022-03-08 | Ucl Business Ltd | Treatment of portal hypertension and restoration of liver function using L-ornithine phenylacetate |
| CN114349652A (en) * | 2021-12-10 | 2022-04-15 | 汕头市佳禾生物科技有限公司 | Preparation method of L-lysine aspartate |
-
1963
- 1963-09-16 GB GB3640563A patent/GB1067742A/en not_active Expired
Cited By (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4447366A (en) * | 1980-12-04 | 1984-05-08 | Morelle Jean V | Derivatives of lysine and aspartic acid |
| EP0477991A1 (en) * | 1990-09-28 | 1992-04-01 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing crystals of salt of acidic amino acid and basic amino acid |
| US10610506B2 (en) | 2004-11-26 | 2020-04-07 | Ucl Business Ltd | Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy |
| US9566257B2 (en) | 2004-11-26 | 2017-02-14 | Ucl Business Plc | Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy |
| US8389576B2 (en) | 2004-11-26 | 2013-03-05 | Ucl Business Plc | Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy |
| US9604909B2 (en) | 2009-04-03 | 2017-03-28 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| US8492439B2 (en) | 2009-04-03 | 2013-07-23 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| US8785498B2 (en) | 2009-04-03 | 2014-07-22 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| US9034925B2 (en) | 2009-04-03 | 2015-05-19 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| US10550069B2 (en) | 2009-04-03 | 2020-02-04 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| US11161802B2 (en) | 2009-04-03 | 2021-11-02 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| US10173964B2 (en) | 2009-04-03 | 2019-01-08 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| US8173706B2 (en) | 2009-04-03 | 2012-05-08 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| US11266620B2 (en) | 2009-06-08 | 2022-03-08 | Ucl Business Ltd | Treatment of portal hypertension and restoration of liver function using L-ornithine phenylacetate |
| US8946473B2 (en) | 2010-10-06 | 2015-02-03 | Ocera Therapeutics, Inc. | Methods of making L-ornithine phenyl acetate |
| US9260379B2 (en) | 2010-10-06 | 2016-02-16 | Ocera Therapeutics, Inc. | Methods of making L-ornithine phenyl acetate |
| CN102827017B (en) * | 2011-06-14 | 2014-07-02 | 上海励睿化学科技有限公司 | Crystal form of double salt compound and preparation method thereof |
| CN102827017A (en) * | 2011-06-14 | 2012-12-19 | 上海励睿化学科技有限公司 | Crystal form of double salt compound and preparation method thereof |
| US10525029B2 (en) | 2014-11-24 | 2020-01-07 | Ucl Business Ltd | Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies |
| US11040021B2 (en) | 2014-11-24 | 2021-06-22 | Ucl Business Ltd | Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies |
| US10039735B2 (en) | 2014-11-24 | 2018-08-07 | Ucl Business Plc | Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies |
| US10835506B2 (en) | 2015-08-18 | 2020-11-17 | Ocera Therapeutics, Inc. | Treatment and prevention of muscle loss using L-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
| US11066352B2 (en) | 2017-05-11 | 2021-07-20 | Ocera Therapeutics, Inc. | Processes of making L-ornithine phenylacetate |
| CN114349652A (en) * | 2021-12-10 | 2022-04-15 | 汕头市佳禾生物科技有限公司 | Preparation method of L-lysine aspartate |
| CN114349652B (en) * | 2021-12-10 | 2024-03-29 | 汕头市佳禾生物科技有限公司 | Preparation method of L-lysine aspartate |
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