GB862159A - Potassium phenoxymethyl penicillin - Google Patents

Potassium phenoxymethyl penicillin

Info

Publication number
GB862159A
GB862159A GB3000458A GB3000458A GB862159A GB 862159 A GB862159 A GB 862159A GB 3000458 A GB3000458 A GB 3000458A GB 3000458 A GB3000458 A GB 3000458A GB 862159 A GB862159 A GB 862159A
Authority
GB
United Kingdom
Prior art keywords
acetate
potassium
phenoxymethylpenicillin
purity
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3000458A
Inventor
William Norman Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Distillers Co Yeast Ltd
Distillers Co Ltd
Original Assignee
Distillers Co Yeast Ltd
Distillers Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Distillers Co Yeast Ltd, Distillers Co Ltd filed Critical Distillers Co Yeast Ltd
Priority to GB3000458A priority Critical patent/GB862159A/en
Publication of GB862159A publication Critical patent/GB862159A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/60—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by oxygen atoms

Abstract

Potassium phenoxymethylpenicillin in the form of needle-shaped crystals is produced in high yield by dissolving solid free phenoxymethylpenicillin of at least 90% purity and preferably of at least 95% purity, in a lower alkanol containing 2 to 4 carbon atoms, or an alkyl acetate or ketone containing not more than seven carbon atoms, mixing the resulting solution with potassium acetate, adjusting the water content of the mixture to within the range of 1 to 5% by volume and thereafter separating the crystals of potassium phenoxymethylpenicillin. The potassium acetate is preferably used in excess and is preferably dissolved in water, the solution of phenoxymethylpenicillin in the organic solvent being added to the aqueous solution of potassium acetate. Maximum yield is obtained at 0 DEG C., but it is preferred to mix the solutions at 28 DEG to 30 DEG C. and then to reduce the temperature to 18 DEG to 20 DEG C. during crystallization. The preferred solvent is isopropanol but others which may be used are acetone, methyl ethyl ketone, ethyl acetate, propyl acetate, butyl acetate and amyl acetate.
GB3000458A 1958-09-19 1958-09-19 Potassium phenoxymethyl penicillin Expired GB862159A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3000458A GB862159A (en) 1958-09-19 1958-09-19 Potassium phenoxymethyl penicillin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3000458A GB862159A (en) 1958-09-19 1958-09-19 Potassium phenoxymethyl penicillin

Publications (1)

Publication Number Publication Date
GB862159A true GB862159A (en) 1961-03-01

Family

ID=10300697

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3000458A Expired GB862159A (en) 1958-09-19 1958-09-19 Potassium phenoxymethyl penicillin

Country Status (1)

Country Link
GB (1) GB862159A (en)

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