GB994402A - Process for the separation of 6-aminopenicillanic acid and ampicillin - Google Patents

Process for the separation of 6-aminopenicillanic acid and ampicillin

Info

Publication number
GB994402A
GB994402A GB3404063A GB3404063A GB994402A GB 994402 A GB994402 A GB 994402A GB 3404063 A GB3404063 A GB 3404063A GB 3404063 A GB3404063 A GB 3404063A GB 994402 A GB994402 A GB 994402A
Authority
GB
United Kingdom
Prior art keywords
trialkylamine
aminopenicillanic acid
mixture
aminobenzyl penicillin
ampicillin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3404063A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of GB994402A publication Critical patent/GB994402A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The separation of 6-aminopenicillanic acid and a -aminobenzyl penicillin from mixtures containing same, is obtained by suspending a solid mixture of 6-aminopenicillanic acid and a -aminobenzyl penicillin in an inert organic solvent capable of dissolving trialkylamine salts of a -aminobenzyl penicillin, cooling the resulting suspension to approximately 0 DEG C., adding thereto one mol. of a trialkylamine per mol. of a -aminobenzylpenicillin contained in the origina-mixture at 0 DEG C. to effect dissolution of the a -aminobenzyl penicillin and filtering the mixture to remove the undissolved 6-aminopenicillanic acid therefrom and recovering from the residual filtrate the ampicillin as its trialkylamine salt. Specified organic solvents are methylene chloride, chloroform, methanol, dimethylformamide, formamide, acetone, acetonitrile, ethanol, demethyl sulphoxide and glycol monomethyl ether. The trialkylamine may be trimethylamine, triethylamine, methyldiethylamine or tripolyamine. Reference has been directed by the Comptroller to Specification 870,396.
GB3404063A 1962-09-04 1963-08-28 Process for the separation of 6-aminopenicillanic acid and ampicillin Expired GB994402A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEF37739A DE1178434B (en) 1962-09-04 1962-09-04 Process for the separation of 6-aminopenicillanic acid and ª ‡ -aminobenzylpenicillin

Publications (1)

Publication Number Publication Date
GB994402A true GB994402A (en) 1965-06-10

Family

ID=7097031

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3404063A Expired GB994402A (en) 1962-09-04 1963-08-28 Process for the separation of 6-aminopenicillanic acid and ampicillin

Country Status (2)

Country Link
DE (1) DE1178434B (en)
GB (1) GB994402A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996030376A1 (en) * 1995-03-31 1996-10-03 Chemferm V.O.F. Process for the recovery of ampicillin
US5916762A (en) * 1995-03-31 1999-06-29 Chemferm V.O.F. Process for the recovery of ampicillin
EP0997199A1 (en) * 1998-10-26 2000-05-03 Dsm N.V. Method for separation of solid compounds in suspension

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES270202A1 (en) * 1960-09-06 1962-02-01 Pfizer & Co C A procedure for the recovery of amphalt amino acids (Machine-translation by Google Translate, not legally binding)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996030376A1 (en) * 1995-03-31 1996-10-03 Chemferm V.O.F. Process for the recovery of ampicillin
BE1009264A3 (en) * 1995-03-31 1997-01-07 Dsm Nv Process for the extraction of ampicillin.
US5916762A (en) * 1995-03-31 1999-06-29 Chemferm V.O.F. Process for the recovery of ampicillin
EP0997199A1 (en) * 1998-10-26 2000-05-03 Dsm N.V. Method for separation of solid compounds in suspension

Also Published As

Publication number Publication date
DE1178434B (en) 1964-09-24

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