GB958478A - Production of penicillins - Google Patents
Production of penicillinsInfo
- Publication number
- GB958478A GB958478A GB817863A GB817863A GB958478A GB 958478 A GB958478 A GB 958478A GB 817863 A GB817863 A GB 817863A GB 817863 A GB817863 A GB 817863A GB 958478 A GB958478 A GB 958478A
- Authority
- GB
- United Kingdom
- Prior art keywords
- penicillin
- organic solvent
- chloride
- methyl
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
- Separation, Recovery Or Treatment Of Waste Materials Containing Plastics (AREA)
Abstract
Penicillins are prepared by mixing 6-amino-penicillanic acid with at least one equivalent of the appropriate acid chloride, bromide or iodide at a pH of from 2 to 4 in an aqueous reaction medium comprising an unstable emulsion of water and a water-immiscible, inert organic solvent at a temperature of from 0 DEG to 50 DEG C., separating the rich organic solvent phase containing the penicillin and recovering the penicillin therefrom. The organic solvent may be an aliphatic ester or ketone such as ethyl acetate or methyl isobutyl ketone. Examples describe the production of a -phenoxyethyl penicillin, 5-methyl-3-phenyl-4-isoxazolylpenicillin, 3-(o-chlorophenyl)-5-methyl-4-isoxazolyl-penicillin and 2-biphenyl-penicillin and of salts thereof. 2-Biphenylcarbonyl chloride may be prepared by reacting 2-biphenylcarboxylic acid with thionyl chloride in solution in methylene chloride in the presence of dimethylformamide as catalyst. Specifications 877,120, 880,400, 892,144 and 905,778 are referred to.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17948662A | 1962-03-13 | 1962-03-13 | |
| US17948762A | 1962-03-13 | 1962-03-13 | |
| US17945662A | 1962-03-13 | 1962-03-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB958478A true GB958478A (en) | 1964-05-21 |
Family
ID=27391121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB817863A Expired GB958478A (en) | 1962-03-13 | 1963-02-28 | Production of penicillins |
Country Status (6)
| Country | Link |
|---|---|
| AT (1) | AT251760B (en) |
| BR (1) | BR6347361D0 (en) |
| CH (1) | CH433317A (en) |
| ES (1) | ES285863A1 (en) |
| GB (1) | GB958478A (en) |
| SE (1) | SE312807B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1053313B (en) * | 1976-01-15 | 1981-08-31 | Ankerfarm Spa | PROCEDURE FOR PRODUCING SEMI-SYNTHETIC ANTIBIOTICS |
| IT1053312B (en) * | 1976-01-15 | 1981-08-31 | Ankerfarm Spa | PROCEDURE FOR THE PRODUCTION OF SEMI-SYNTHETIC PENICILLIN ANTIBIOTICS |
-
1963
- 1963-02-28 GB GB817863A patent/GB958478A/en not_active Expired
- 1963-03-05 BR BR14736163A patent/BR6347361D0/en unknown
- 1963-03-06 AT AT175263A patent/AT251760B/en active
- 1963-03-08 ES ES285863A patent/ES285863A1/en not_active Expired
- 1963-03-12 SE SE272263A patent/SE312807B/xx unknown
- 1963-03-13 CH CH318863A patent/CH433317A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES285863A1 (en) | 1963-06-16 |
| SE312807B (en) | 1969-07-28 |
| BR6347361D0 (en) | 1973-08-28 |
| CH433317A (en) | 1967-04-15 |
| AT251760B (en) | 1967-01-25 |
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