GB936062A - Method of producing 2-pyridinealdoxime methochloride - Google Patents

Method of producing 2-pyridinealdoxime methochloride

Info

Publication number
GB936062A
GB936062A GB1293562A GB1293562A GB936062A GB 936062 A GB936062 A GB 936062A GB 1293562 A GB1293562 A GB 1293562A GB 1293562 A GB1293562 A GB 1293562A GB 936062 A GB936062 A GB 936062A
Authority
GB
United Kingdom
Prior art keywords
pyridinealdoxime
methochloride
mixture
organic solvent
sulphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1293562A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Campbell Pharmaceuticals Inc
Original Assignee
Campbell Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Campbell Pharmaceuticals Inc filed Critical Campbell Pharmaceuticals Inc
Publication of GB936062A publication Critical patent/GB936062A/en
Expired legal-status Critical Current

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  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

2-Pyridinealdoxime methochloride is prepared by forming a mixture of 2-pyridinealdoxime methomethyl sulphate with from 1 to 5 mols of hydrogen chloride per mol of methylsulphate salt, from 0,35 to 1,6 cc. of water per gram of methylsulphate salt, and from 6 to 15 volumes of a water miscible organic solvent to each volume of water. The process may be carried out by: -(a) dissolving 2-pyridine aldoxime metho-methyl sulphate in concentrated hydrochloric acid and then adding the organic solvent, or (b) adding solid 2-pyridinealdoxime methomethylsulphate to a mixture of concentrated hydrochloric acid and organic solvent. The methochloride compound has pharmaceutical properties. 2-Pyridine aldoxime metho-methyl sulphate is prepared by adding dimethyl sulphate to a solution of 2-pyridine aldoxime in acetone and allowing the mixture to crystallise.
GB1293562A 1961-05-05 1962-04-04 Method of producing 2-pyridinealdoxime methochloride Expired GB936062A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10789461A 1961-05-05 1961-05-05

Publications (1)

Publication Number Publication Date
GB936062A true GB936062A (en) 1963-09-04

Family

ID=22319029

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1293562A Expired GB936062A (en) 1961-05-05 1962-04-04 Method of producing 2-pyridinealdoxime methochloride

Country Status (1)

Country Link
GB (1) GB936062A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1216310B (en) * 1965-11-26 1966-05-12 Dr Joerg Schnekenburger Process for the preparation of pyridine-N-oxide-2-aldoxime
US4263305A (en) * 1979-03-12 1981-04-21 Interx Research Corporation Novel pyridiniumaldoximes having micellar characteristics

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1216310B (en) * 1965-11-26 1966-05-12 Dr Joerg Schnekenburger Process for the preparation of pyridine-N-oxide-2-aldoxime
US4263305A (en) * 1979-03-12 1981-04-21 Interx Research Corporation Novel pyridiniumaldoximes having micellar characteristics

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