GB1069820A - Tuberculostatic compounds - Google Patents
Tuberculostatic compoundsInfo
- Publication number
- GB1069820A GB1069820A GB5411865A GB5411865A GB1069820A GB 1069820 A GB1069820 A GB 1069820A GB 5411865 A GB5411865 A GB 5411865A GB 5411865 A GB5411865 A GB 5411865A GB 1069820 A GB1069820 A GB 1069820A
- Authority
- GB
- United Kingdom
- Prior art keywords
- oxydextran
- water
- hydrazone
- isoniazide
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Water-soluble salts of oxydextran isonicotinoyl hydrazone are made by reacting oxydextran (dialdehyde dextran) in an aqueous medium with isoniazide in a molar ratio of 1:1 to 1:6 (basic mol. of oxydextran:mol. isoniazide) and dissolving the resulting water-insoluble hydrazone in a not dilute mineral acid at about 30 DEG C. to give a water-soluble salt. Specified salts are hydrochloride and sulphate. Hydrazone formation may be carried out at ambient temperature, and the product may be purified by precipitation and washing with methanol before dissolving in dilute acid hydrochloric or sulphuric acid to form the salt, which may be isolated by precipitation from the reaction mixture with acetone or methanol. The compounds are used as tuberculostatics.ALSO:Parenterally-administered tuberculostatics of low toxicity which provide an isoniazide blood level lying within the therapeutic range over a long period of time comprise water-soluble salts of oxydextran isonicotinoyl hydrazone. The salts may be hydrochloride or sulphate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5411865A GB1069820A (en) | 1965-12-21 | 1965-12-21 | Tuberculostatic compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5411865A GB1069820A (en) | 1965-12-21 | 1965-12-21 | Tuberculostatic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1069820A true GB1069820A (en) | 1967-05-24 |
Family
ID=10469973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5411865A Expired GB1069820A (en) | 1965-12-21 | 1965-12-21 | Tuberculostatic compounds |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1069820A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA011717B1 (en) * | 2008-03-21 | 2009-04-28 | Государственное Учреждение Научный Центр Клинической и Экспериментальной Медицины Сибирского отделения Российской академии медицинских наук | A method for production of conjugate of dialdehydedextran with isoniazid |
| EP3169336A4 (en) * | 2014-07-17 | 2018-04-04 | Ohio State Innovation Foundation | Compositions for targeting macrophages and other cd206 high expressing cells and methods of treating and diagnosis |
| US10806803B2 (en) | 2014-07-17 | 2020-10-20 | Ohio State Innovation Foundation | Compositions for targeting macrophages and other CD206 high expressing cells and methods of treating and diagnosis |
| US12006339B2 (en) | 2022-05-20 | 2024-06-11 | Navidea Biopharmaceuticals, Inc. | CD206 targeted drug delivery vehicles carrying novel bisphosphonate drug payloads via a degradable linker |
| US12005122B2 (en) | 2016-10-07 | 2024-06-11 | Navidea Biopharmaceuticals, Inc. | Compounds and methods for diagnosis and treatment of viral infections |
-
1965
- 1965-12-21 GB GB5411865A patent/GB1069820A/en not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA011717B1 (en) * | 2008-03-21 | 2009-04-28 | Государственное Учреждение Научный Центр Клинической и Экспериментальной Медицины Сибирского отделения Российской академии медицинских наук | A method for production of conjugate of dialdehydedextran with isoniazid |
| EP3169336A4 (en) * | 2014-07-17 | 2018-04-04 | Ohio State Innovation Foundation | Compositions for targeting macrophages and other cd206 high expressing cells and methods of treating and diagnosis |
| US10806803B2 (en) | 2014-07-17 | 2020-10-20 | Ohio State Innovation Foundation | Compositions for targeting macrophages and other CD206 high expressing cells and methods of treating and diagnosis |
| US12005122B2 (en) | 2016-10-07 | 2024-06-11 | Navidea Biopharmaceuticals, Inc. | Compounds and methods for diagnosis and treatment of viral infections |
| US12006339B2 (en) | 2022-05-20 | 2024-06-11 | Navidea Biopharmaceuticals, Inc. | CD206 targeted drug delivery vehicles carrying novel bisphosphonate drug payloads via a degradable linker |
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