GB1305860A - - Google Patents
Info
- Publication number
- GB1305860A GB1305860A GB5880771A GB5880771A GB1305860A GB 1305860 A GB1305860 A GB 1305860A GB 5880771 A GB5880771 A GB 5880771A GB 5880771 A GB5880771 A GB 5880771A GB 1305860 A GB1305860 A GB 1305860A
- Authority
- GB
- United Kingdom
- Prior art keywords
- doxycycline
- volume
- organic solvent
- aqueous organic
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1305860 Purification of doxycycline ALFA FARMACEUTICI SpA 17 Dec 1971 [31 March 1971] 58807/71 Heading C2A A process for purifying the 6-α-epimer of doxycycline of Formula I comprises precipitating 6-α-doxycycline 5-sul phosalicylate by means of sulphosalicylic acid from a solution of impure doxycycline (or a salt thereof) in an aqueous organic solvent containing from 20 to 70% by volume of water and from 80 to 30% by volume of N,N-dimethylformamide, N,N,-dimethylacetamide, dimethylsulphoxide or acetone. Such an aqueous organic solvent may preferably contain from 40 to 60% by volume of water. In a preferred process, 15 to 25 parts by volume of the aqueous organic solvent are used for each part by weight of 6α- doxycycline. The 6α-doxycycline 5-sulphosalicylate may be precipitated by adding to a solution containing doxycycline 5À5 to 6À5 moles of 5-sulphosalicylic acid per mole of 6α-doxycycline. The 5-sulphosalicylate salt produced may be converted into the free base of doxycycline or into another salt thereof. The process may be used for purifying doxycycline which has been produced by catalytic hydrogenation of methacycline.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT338071 | 1971-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1305860A true GB1305860A (en) | 1973-02-07 |
Family
ID=11106027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5880771A Expired GB1305860A (en) | 1971-03-31 | 1971-12-17 |
Country Status (8)
| Country | Link |
|---|---|
| AT (1) | AT309680B (en) |
| BE (1) | BE770527A (en) |
| DE (1) | DE2136622A1 (en) |
| ES (1) | ES394777A1 (en) |
| FR (1) | FR2131926A1 (en) |
| GB (1) | GB1305860A (en) |
| NL (1) | NL7109741A (en) |
| ZA (1) | ZA714767B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6077822A (en) * | 1993-09-14 | 2000-06-20 | Dumex-Alpharma A/S | Drug salts |
| CN111443139A (en) * | 2020-03-13 | 2020-07-24 | 扬州联博药业有限公司 | Method for simultaneously detecting relative retention time and peak purity of doxycycline and related substances in doxycycline hydrochloride |
| CN114835603A (en) * | 2022-06-17 | 2022-08-02 | 盐城苏海制药有限公司 | Synthesis method for directly synthesizing doxycycline hydrochloride from hydride |
-
1971
- 1971-07-14 NL NL7109741A patent/NL7109741A/xx unknown
- 1971-07-19 ZA ZA714767A patent/ZA714767B/en unknown
- 1971-07-22 DE DE19712136622 patent/DE2136622A1/de active Pending
- 1971-07-23 AT AT643771A patent/AT309680B/en active
- 1971-07-27 BE BE770527A patent/BE770527A/en unknown
- 1971-09-03 ES ES394777A patent/ES394777A1/en not_active Expired
- 1971-10-13 FR FR7136764A patent/FR2131926A1/en not_active Withdrawn
- 1971-12-17 GB GB5880771A patent/GB1305860A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6077822A (en) * | 1993-09-14 | 2000-06-20 | Dumex-Alpharma A/S | Drug salts |
| CN111443139A (en) * | 2020-03-13 | 2020-07-24 | 扬州联博药业有限公司 | Method for simultaneously detecting relative retention time and peak purity of doxycycline and related substances in doxycycline hydrochloride |
| CN114835603A (en) * | 2022-06-17 | 2022-08-02 | 盐城苏海制药有限公司 | Synthesis method for directly synthesizing doxycycline hydrochloride from hydride |
Also Published As
| Publication number | Publication date |
|---|---|
| AT309680B (en) | 1973-08-27 |
| DE2136622A1 (en) | 1972-10-12 |
| FR2131926A1 (en) | 1972-11-17 |
| NL7109741A (en) | 1972-10-03 |
| ZA714767B (en) | 1972-10-25 |
| ES394777A1 (en) | 1974-03-01 |
| BE770527A (en) | 1971-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 414F | Notice of opposition given (sect. 14/1949) | ||
| 414E | Application relinquished (sect. 14/1949) | ||
| CSNS | Application of which complete specification have been accepted and published, but patent is not sealed |