FR2339618A1 - (11)-Amino-vincamones useful as cerebral circulation regulators - prepd. from (11)-nitro-vincamines by reduction and treatment with a base - Google Patents
(11)-Amino-vincamones useful as cerebral circulation regulators - prepd. from (11)-nitro-vincamines by reduction and treatment with a baseInfo
- Publication number
- FR2339618A1 FR2339618A1 FR7602603A FR7602603A FR2339618A1 FR 2339618 A1 FR2339618 A1 FR 2339618A1 FR 7602603 A FR7602603 A FR 7602603A FR 7602603 A FR7602603 A FR 7602603A FR 2339618 A1 FR2339618 A1 FR 2339618A1
- Authority
- FR
- France
- Prior art keywords
- base
- nitro
- amino
- vincamones
- vincamines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
11-Aminovincamones are prepared from 11-nitrovincamines by a process in which, in either order, the nitro group is reduced to an amino group and the vincamine is transformed into a vincamone by the action of a base. A typical prod. is (-) 11-aminovincamone. In an example, this was prepared as follows; 5 g (-)11-nitrovincamine was treated with 1.3 g K tert butylate in anhydrous benzene, refluxing for 6 hours, to give 3.5 g (-)11-nitrovincamone, m.pt. 186-188 degrees C. 3 g of this prod. in 50 ml 78% ethanol was treated with a solution of 200 mg calcium chloride in 0.3 ml water and 6 g powdered zinc. 2 hrs. reflux gave 2.1 g 11-aminovincamone, m.pt. 226-227 degrees C.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7602603A FR2339618A1 (en) | 1976-01-30 | 1976-01-30 | (11)-Amino-vincamones useful as cerebral circulation regulators - prepd. from (11)-nitro-vincamines by reduction and treatment with a base |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7602603A FR2339618A1 (en) | 1976-01-30 | 1976-01-30 | (11)-Amino-vincamones useful as cerebral circulation regulators - prepd. from (11)-nitro-vincamines by reduction and treatment with a base |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2339618A1 true FR2339618A1 (en) | 1977-08-26 |
FR2339618B1 FR2339618B1 (en) | 1980-03-07 |
Family
ID=9168589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7602603A Granted FR2339618A1 (en) | 1976-01-30 | 1976-01-30 | (11)-Amino-vincamones useful as cerebral circulation regulators - prepd. from (11)-nitro-vincamines by reduction and treatment with a base |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2339618A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4356305A (en) * | 1979-08-13 | 1982-10-26 | Richter Gedeon Vegyeszeti Gyar Rt. | Process for the preparation of halovincamone derivatives |
DE3322686A1 (en) * | 1982-06-30 | 1984-02-16 | Richter Gedeon Vegyészeti Gyár R.T., 1475 Budapest | NEW EBURNE DERIVATIVES, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM |
DE3409185A1 (en) * | 1984-04-12 | 1985-09-26 | Consiglio Nazionale Delle Ricerche, Rom/Roma | Process for the preparation of eburnamonines by electrochemical means |
US5093337A (en) * | 1987-11-19 | 1992-03-03 | Roussel Uclaf | Substituted derivatives of 20,21-dinoreburnamenine, their use as medicaments and the pharmaceutical compositions containing them |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2320302A1 (en) * | 1975-08-05 | 1977-03-04 | Omnium Chimique Sa | (11)-Amino-vincamine prepd. by nitration and then redn. of vincamine - is used as a cerebral vasoregulator |
-
1976
- 1976-01-30 FR FR7602603A patent/FR2339618A1/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2320302A1 (en) * | 1975-08-05 | 1977-03-04 | Omnium Chimique Sa | (11)-Amino-vincamine prepd. by nitration and then redn. of vincamine - is used as a cerebral vasoregulator |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4356305A (en) * | 1979-08-13 | 1982-10-26 | Richter Gedeon Vegyeszeti Gyar Rt. | Process for the preparation of halovincamone derivatives |
DE3322686A1 (en) * | 1982-06-30 | 1984-02-16 | Richter Gedeon Vegyészeti Gyár R.T., 1475 Budapest | NEW EBURNE DERIVATIVES, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM |
DE3409185A1 (en) * | 1984-04-12 | 1985-09-26 | Consiglio Nazionale Delle Ricerche, Rom/Roma | Process for the preparation of eburnamonines by electrochemical means |
US5093337A (en) * | 1987-11-19 | 1992-03-03 | Roussel Uclaf | Substituted derivatives of 20,21-dinoreburnamenine, their use as medicaments and the pharmaceutical compositions containing them |
Also Published As
Publication number | Publication date |
---|---|
FR2339618B1 (en) | 1980-03-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |