FR2320302A1 - (11)-Amino-vincamine prepd. by nitration and then redn. of vincamine - is used as a cerebral vasoregulator - Google Patents
(11)-Amino-vincamine prepd. by nitration and then redn. of vincamine - is used as a cerebral vasoregulatorInfo
- Publication number
- FR2320302A1 FR2320302A1 FR7524390A FR7524390A FR2320302A1 FR 2320302 A1 FR2320302 A1 FR 2320302A1 FR 7524390 A FR7524390 A FR 7524390A FR 7524390 A FR7524390 A FR 7524390A FR 2320302 A1 FR2320302 A1 FR 2320302A1
- Authority
- FR
- France
- Prior art keywords
- vincamine
- redn
- nitration
- prepd
- vasoregulator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
11-Aminovincamine of formula (I) in dextro- and laevo-rotatory forms and the racemic mixt. are prepd. by the nitration of vincamine of formula (II) to form 11-nitro vincamine of (III) and redn. of this prod.: The nitration is effected using nitric acid in glacial acetic acid. the redn. may be effected using H2/Raney Ni, SnCl2 in HCl or Zn/HCl. In an example, 25g. (II) was nitrated with a mixt. of 100ml. glacial acetic acid and 100ml. nitric acid (d = 1.52) to give 22.4g. (III) m.pt. 196-197 degrees C. 18g (III) was dissolved in 500ml. methanol and 3g. Raney nickel added. Hydrogenation gave 13.6g. (I), m.pt.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7524390A FR2320302A1 (en) | 1975-08-05 | 1975-08-05 | (11)-Amino-vincamine prepd. by nitration and then redn. of vincamine - is used as a cerebral vasoregulator |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7524390A FR2320302A1 (en) | 1975-08-05 | 1975-08-05 | (11)-Amino-vincamine prepd. by nitration and then redn. of vincamine - is used as a cerebral vasoregulator |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2320302A1 true FR2320302A1 (en) | 1977-03-04 |
FR2320302B3 FR2320302B3 (en) | 1978-03-24 |
Family
ID=9158774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7524390A Granted FR2320302A1 (en) | 1975-08-05 | 1975-08-05 | (11)-Amino-vincamine prepd. by nitration and then redn. of vincamine - is used as a cerebral vasoregulator |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2320302A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2339618A1 (en) * | 1976-01-30 | 1977-08-26 | Omnium Chimique Sa | (11)-Amino-vincamones useful as cerebral circulation regulators - prepd. from (11)-nitro-vincamines by reduction and treatment with a base |
EP0170926A1 (en) * | 1984-07-11 | 1986-02-12 | Richter Gedeon Vegyeszeti Gyar R.T. | Eburnanecarboxylic acid derivatives having an amino group in position 9 or 11, the amino group eventually being substituted, process for their preparation, and medicaments containing these compounds |
EP0173824A1 (en) * | 1984-07-11 | 1986-03-12 | Richter Gedeon Vegyészeti Gyár R.T. | Racemic or optically active 9- respectively 11-substituted apovincamine acid derivatives and process for their preparation |
EP0307167A2 (en) * | 1987-09-07 | 1989-03-15 | Taisho Pharmaceutical Co. Ltd | Vincaminic acid derivatives |
-
1975
- 1975-08-05 FR FR7524390A patent/FR2320302A1/en active Granted
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2339618A1 (en) * | 1976-01-30 | 1977-08-26 | Omnium Chimique Sa | (11)-Amino-vincamones useful as cerebral circulation regulators - prepd. from (11)-nitro-vincamines by reduction and treatment with a base |
EP0170926A1 (en) * | 1984-07-11 | 1986-02-12 | Richter Gedeon Vegyeszeti Gyar R.T. | Eburnanecarboxylic acid derivatives having an amino group in position 9 or 11, the amino group eventually being substituted, process for their preparation, and medicaments containing these compounds |
EP0173824A1 (en) * | 1984-07-11 | 1986-03-12 | Richter Gedeon Vegyészeti Gyár R.T. | Racemic or optically active 9- respectively 11-substituted apovincamine acid derivatives and process for their preparation |
EP0307167A2 (en) * | 1987-09-07 | 1989-03-15 | Taisho Pharmaceutical Co. Ltd | Vincaminic acid derivatives |
EP0307167A3 (en) * | 1987-09-07 | 1990-01-24 | Taisho Pharmaceutical Co. Ltd | Vincaminic acid derivatives |
Also Published As
Publication number | Publication date |
---|---|
FR2320302B3 (en) | 1978-03-24 |
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