ES394777A1 - Procedure for isolating and purifying 6 - alpha - desoxy - 5 - hydroxytetracicline. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for isolating and purifying 6 - alpha - desoxy - 5 - hydroxytetracicline. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES394777A1 ES394777A1 ES394777A ES394777A ES394777A1 ES 394777 A1 ES394777 A1 ES 394777A1 ES 394777 A ES394777 A ES 394777A ES 394777 A ES394777 A ES 394777A ES 394777 A1 ES394777 A1 ES 394777A1
- Authority
- ES
- Spain
- Prior art keywords
- doxycycline
- translation
- procedure
- machine
- catalytic hydrogenation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedure to isolate and purify 6-α-deoxy-5-hydroxytetracycline (Doxycycline), characterized in that the Doxycycline obtained by catalytic hydrogenation of 6-deoxy-6-methylene-6-dimethyl-5-hydroxytetracycline (or another tetracycline compound that produces Doxycycline by catalytic hydrogenation), is precipitated as an insoluble salt by 5-sulfosalicylic acid from an organic polar solution that has the appropriate concentration of water, and this solution contains, together with Doxycycline, its β-epimer, the product starting not hydrogenated plus other secondary products formed during the catalytic hydrogenation, this precipitation is done to obtain fundamentally pure Doxycycline in the form of 5-sulfosalicylate from which the basic Doxycycline is obtained or as a pharmaceutically suitable salt, treating the sulfosalicylate with an acidic substance or basic capable of displacing sulfosalicylic acid from the molecule. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT338071 | 1971-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES394777A1 true ES394777A1 (en) | 1974-03-01 |
Family
ID=11106027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES394777A Expired ES394777A1 (en) | 1971-03-31 | 1971-09-03 | Procedure for isolating and purifying 6 - alpha - desoxy - 5 - hydroxytetracicline. (Machine-translation by Google Translate, not legally binding) |
Country Status (8)
| Country | Link |
|---|---|
| AT (1) | AT309680B (en) |
| BE (1) | BE770527A (en) |
| DE (1) | DE2136622A1 (en) |
| ES (1) | ES394777A1 (en) |
| FR (1) | FR2131926A1 (en) |
| GB (1) | GB1305860A (en) |
| NL (1) | NL7109741A (en) |
| ZA (1) | ZA714767B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6077822A (en) * | 1993-09-14 | 2000-06-20 | Dumex-Alpharma A/S | Drug salts |
| CN111443139A (en) * | 2020-03-13 | 2020-07-24 | 扬州联博药业有限公司 | Method for simultaneously detecting relative retention time and peak purity of doxycycline and related substances in doxycycline hydrochloride |
| CN114835603A (en) * | 2022-06-17 | 2022-08-02 | 盐城苏海制药有限公司 | Synthesis method for directly synthesizing doxycycline hydrochloride from hydride |
-
1971
- 1971-07-14 NL NL7109741A patent/NL7109741A/xx unknown
- 1971-07-19 ZA ZA714767A patent/ZA714767B/en unknown
- 1971-07-22 DE DE19712136622 patent/DE2136622A1/de active Pending
- 1971-07-23 AT AT643771A patent/AT309680B/en active
- 1971-07-27 BE BE770527A patent/BE770527A/en unknown
- 1971-09-03 ES ES394777A patent/ES394777A1/en not_active Expired
- 1971-10-13 FR FR7136764A patent/FR2131926A1/en not_active Withdrawn
- 1971-12-17 GB GB5880771A patent/GB1305860A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE770527A (en) | 1971-12-01 |
| AT309680B (en) | 1973-08-27 |
| GB1305860A (en) | 1973-02-07 |
| FR2131926A1 (en) | 1972-11-17 |
| ZA714767B (en) | 1972-10-25 |
| NL7109741A (en) | 1972-10-03 |
| DE2136622A1 (en) | 1972-10-12 |
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