GB1327048A - Antibiotics - Google Patents
AntibioticsInfo
- Publication number
- GB1327048A GB1327048A GB1175470A GB1327048DA GB1327048A GB 1327048 A GB1327048 A GB 1327048A GB 1175470 A GB1175470 A GB 1175470A GB 1327048D A GB1327048D A GB 1327048DA GB 1327048 A GB1327048 A GB 1327048A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cephalexin
- solvate
- acetonitrile
- crystalline
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
1327048 Purification of cephalexin GLAXO LABORATORIES Ltd 19 April 1971 [11 March 1970] 11754/70 Heading C2A A process for the purification of cephalexin, i.e. 7# - (D - 2 - amino - 2 - phenylacetamido)- 3-methylceph-3-en-4 carboxylic acid, containing impurities, which comprises contacting an aqueous acid solution of said cephalexin with acetonitrile in quantities such that the volume of acetonitrile present is at least 70% of the volume of water, bringing the pH of the solution to from 3À5 to 4À5 by the addition of a base, e.g. ammonia or a triethylenine, so that a crystalline acetonitrile solvate of cephalexin forms, separating the solvate thereby obtained, suspending the solvate in water at a temperature of at least 58‹ C., allowing said crystalline solvate to dissolve therein, and recovering pure, substantially acetonitrile free, crystalline cephalexin from said solution. Reference has been directed by the Comptroller to Specification 1,174,335.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1175470 | 1970-03-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1327048A true GB1327048A (en) | 1973-08-15 |
Family
ID=9992094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1175470A Expired GB1327048A (en) | 1970-03-11 | 1971-04-19 | Antibiotics |
Country Status (10)
| Country | Link |
|---|---|
| AT (1) | AT302528B (en) |
| BE (1) | BE764055A (en) |
| CH (1) | CH559754A5 (en) |
| DE (1) | DE2111522A1 (en) |
| DK (1) | DK127188B (en) |
| FR (1) | FR2084422A5 (en) |
| GB (1) | GB1327048A (en) |
| NL (1) | NL7103177A (en) |
| SE (1) | SE380268B (en) |
| ZA (1) | ZA711555B (en) |
-
1971
- 1971-03-10 DK DK111171AA patent/DK127188B/en unknown
- 1971-03-10 DE DE19712111522 patent/DE2111522A1/en active Pending
- 1971-03-10 NL NL7103177A patent/NL7103177A/xx unknown
- 1971-03-10 FR FR7108270A patent/FR2084422A5/fr not_active Expired
- 1971-03-10 ZA ZA711555A patent/ZA711555B/en unknown
- 1971-03-10 CH CH353671A patent/CH559754A5/xx not_active IP Right Cessation
- 1971-03-10 SE SE7103090A patent/SE380268B/en unknown
- 1971-03-10 AT AT207771A patent/AT302528B/en not_active IP Right Cessation
- 1971-03-10 BE BE764055A patent/BE764055A/en unknown
- 1971-04-19 GB GB1175470A patent/GB1327048A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE764055A (en) | 1971-08-02 |
| CH559754A5 (en) | 1975-03-14 |
| FR2084422A5 (en) | 1971-12-17 |
| DE2111522A1 (en) | 1971-09-30 |
| NL7103177A (en) | 1971-09-14 |
| ZA711555B (en) | 1972-10-25 |
| DK127188B (en) | 1973-10-01 |
| AT302528B (en) | 1972-10-25 |
| SE380268B (en) | 1975-11-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |