GB1472396A - Resolution of 2-deutero-3-fluoroalanine - Google Patents
Resolution of 2-deutero-3-fluoroalanineInfo
- Publication number
- GB1472396A GB1472396A GB3148875A GB3148875A GB1472396A GB 1472396 A GB1472396 A GB 1472396A GB 3148875 A GB3148875 A GB 3148875A GB 3148875 A GB3148875 A GB 3148875A GB 1472396 A GB1472396 A GB 1472396A
- Authority
- GB
- United Kingdom
- Prior art keywords
- solution
- deutero
- mixture
- fluoroalanine
- july
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- UYTSRQMXRROFPU-MYSWAXPFSA-N (2r)-2-amino-2-deuterio-3-fluoropropanoic acid Chemical compound FC[C@@](N)([2H])C(O)=O UYTSRQMXRROFPU-MYSWAXPFSA-N 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 3
- UYTSRQMXRROFPU-VMNATFBRSA-N 2-amino-2-deuterio-3-fluoropropanoic acid Chemical class FCC(N)([2H])C(O)=O UYTSRQMXRROFPU-VMNATFBRSA-N 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 239000012452 mother liquor Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/34—Preparation of optical isomers by separation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/20—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
1472396 2-Deutero-3-fluoroalanine MERCK & CO Inc 28 July 1975 [31 July 1974] 31488/75 Heading C2C A process for resolving a DL-mixture of a 2- deutero-3-fluoro-DL-alanine salt, comprises preparing a saturated C 1-6 alkanolic solution of said DL-mixture in a solution zone; transforming the said solution into a supersaturated solution of the DL-mixture; contacting the supersaturated solution with crystals of one of the corresponding individual isomers, thereby crystallizing the said isomer from the said solution ; and recovering the other individual isomer from the resulting mother liquor.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49335274A | 1974-07-31 | 1974-07-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1472396A true GB1472396A (en) | 1977-05-04 |
Family
ID=23959889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3148875A Expired GB1472396A (en) | 1974-07-31 | 1975-07-28 | Resolution of 2-deutero-3-fluoroalanine |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS5139626A (en) |
| AR (1) | AR207648A1 (en) |
| AU (1) | AU497991B2 (en) |
| BE (1) | BE831760A (en) |
| CA (1) | CA1054158A (en) |
| CH (1) | CH598194A5 (en) |
| CS (1) | CS191271B2 (en) |
| DD (1) | DD119209A5 (en) |
| DE (1) | DE2534031A1 (en) |
| DK (1) | DK345875A (en) |
| ES (1) | ES439857A1 (en) |
| FI (1) | FI752130A (en) |
| FR (1) | FR2280366A1 (en) |
| GB (1) | GB1472396A (en) |
| HU (1) | HU170472B (en) |
| IE (1) | IE41498B1 (en) |
| LU (1) | LU73100A1 (en) |
| NL (1) | NL7508925A (en) |
| NO (1) | NO752551L (en) |
| PL (1) | PL103968B1 (en) |
| SE (1) | SE7508553L (en) |
| SU (1) | SU568362A3 (en) |
| YU (1) | YU190675A (en) |
| ZA (1) | ZA754918B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4028405A (en) * | 1974-10-15 | 1977-06-07 | Merck & Co., Inc. | Fluorinated amino acids |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7300576A (en) * | 1972-02-03 | 1973-08-07 |
-
1975
- 1975-01-01 AR AR259830A patent/AR207648A1/en active
- 1975-07-17 IE IE1592/75A patent/IE41498B1/en unknown
- 1975-07-17 NO NO752751A patent/NO752551L/no unknown
- 1975-07-21 CA CA231,941A patent/CA1054158A/en not_active Expired
- 1975-07-23 AU AU83316/75A patent/AU497991B2/en not_active Expired
- 1975-07-24 CH CH968275A patent/CH598194A5/xx not_active IP Right Cessation
- 1975-07-24 FI FI752130A patent/FI752130A/fi not_active Application Discontinuation
- 1975-07-25 NL NL7508925A patent/NL7508925A/en not_active Application Discontinuation
- 1975-07-25 YU YU01906/75A patent/YU190675A/en unknown
- 1975-07-25 BE BE158335A patent/BE831760A/en not_active IP Right Cessation
- 1975-07-28 SE SE7508553A patent/SE7508553L/en unknown
- 1975-07-28 GB GB3148875A patent/GB1472396A/en not_active Expired
- 1975-07-29 FR FR7523617A patent/FR2280366A1/en active Granted
- 1975-07-29 DD DD187544A patent/DD119209A5/xx unknown
- 1975-07-30 LU LU73100A patent/LU73100A1/xx unknown
- 1975-07-30 PL PL1975182389A patent/PL103968B1/en unknown
- 1975-07-30 ZA ZA754918A patent/ZA754918B/en unknown
- 1975-07-30 DE DE19752534031 patent/DE2534031A1/en active Pending
- 1975-07-30 DK DK345875A patent/DK345875A/en unknown
- 1975-07-30 SU SU7502163062A patent/SU568362A3/en active
- 1975-07-30 CS CS755338A patent/CS191271B2/en unknown
- 1975-07-30 ES ES439857A patent/ES439857A1/en not_active Expired
- 1975-07-31 JP JP50092656A patent/JPS5139626A/en active Pending
- 1975-07-31 HU HUME1881A patent/HU170472B/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE41498B1 (en) | 1980-01-16 |
| DD119209A5 (en) | 1976-04-12 |
| SE7508553L (en) | 1976-02-02 |
| CS191271B2 (en) | 1979-06-29 |
| DK345875A (en) | 1976-02-01 |
| NO752551L (en) | 1976-02-03 |
| HU170472B (en) | 1977-06-28 |
| SU568362A3 (en) | 1977-08-05 |
| AR207648A1 (en) | 1976-10-22 |
| IE41498L (en) | 1976-01-31 |
| AU497991B2 (en) | 1979-02-01 |
| BE831760A (en) | 1976-01-26 |
| FR2280366B1 (en) | 1982-07-30 |
| YU190675A (en) | 1984-02-29 |
| FI752130A (en) | 1976-02-01 |
| AU8331675A (en) | 1977-01-27 |
| LU73100A1 (en) | 1976-05-31 |
| CA1054158A (en) | 1979-05-08 |
| NL7508925A (en) | 1976-02-03 |
| JPS5139626A (en) | 1976-04-02 |
| ES439857A1 (en) | 1977-06-16 |
| FR2280366A1 (en) | 1976-02-27 |
| PL103968B1 (en) | 1979-07-31 |
| CH598194A5 (en) | 1978-04-28 |
| DE2534031A1 (en) | 1976-02-12 |
| ZA754918B (en) | 1977-03-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19920728 |