GB896089A - Derivatives of thiamine and their production - Google Patents
Derivatives of thiamine and their productionInfo
- Publication number
- GB896089A GB896089A GB12065/60A GB1206560A GB896089A GB 896089 A GB896089 A GB 896089A GB 12065/60 A GB12065/60 A GB 12065/60A GB 1206560 A GB1206560 A GB 1206560A GB 896089 A GB896089 A GB 896089A
- Authority
- GB
- United Kingdom
- Prior art keywords
- thiamine
- derivatives
- production
- salts
- monophosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003544 thiamines Chemical class 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- ZFBDZUHAVTWHSL-UHFFFAOYSA-M S(=S)(=O)(OC(C1=CC=CC=C1)=O)[O-].[Na+] Chemical compound S(=S)(=O)(OC(C1=CC=CC=C1)=O)[O-].[Na+] ZFBDZUHAVTWHSL-UHFFFAOYSA-M 0.000 abstract 1
- BTNNPSLJPBRMLZ-LGMDPLHJSA-N benfotiamine Chemical compound C=1C=CC=CC=1C(=O)SC(/CCOP(O)(O)=O)=C(/C)N(C=O)CC1=CN=C(C)N=C1N BTNNPSLJPBRMLZ-LGMDPLHJSA-N 0.000 abstract 1
- PASDCCFISLVPSO-UHFFFAOYSA-N benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 abstract 1
- 239000000920 calcium hydroxide Substances 0.000 abstract 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- YYWLHHUMIIIZDH-UHFFFAOYSA-N s-benzoylsulfanyl benzenecarbothioate Chemical compound C=1C=CC=CC=1C(=O)SSC(=O)C1=CC=CC=C1 YYWLHHUMIIIZDH-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 235000020955 thiamine monophosphate Nutrition 0.000 abstract 1
- 239000011621 thiamine monophosphate Substances 0.000 abstract 1
- GUGWNSHJDUEHNJ-UHFFFAOYSA-N thiamine(1+) monophosphate chloride Chemical compound [Cl-].CC1=C(CCOP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N GUGWNSHJDUEHNJ-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/113—Esters of phosphoric acids with unsaturated acyclic alcohols
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises S-benzoylthiamine O-monophosphate having the formula <FORM:0896089/IV (b)/1> and salts thereof. The phosphate may be prepared by reacting thiamine monophosphate with benzoyl chloride or sodium benzoyl thiosulphate or dibenzoyl disulphide at a pH of 7-14 in water or in an aqueous organic solvent such as aqueous methanol, ethanol or acetone at a temperature of 0 DEG C.-30 DEG C. Salts may be obtained by adding calcium or sodium hydroxide.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP896089X | 1959-04-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB896089A true GB896089A (en) | 1962-05-09 |
Family
ID=13975464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB12065/60A Expired GB896089A (en) | 1959-04-14 | 1960-04-05 | Derivatives of thiamine and their production |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB896089A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101654464B (en) * | 2009-07-28 | 2012-05-23 | 华中药业股份有限公司 | Method for synthesizing vitamin B1 phosphatic monoester |
| CN103113405A (en) * | 2012-10-17 | 2013-05-22 | 上海日馨生物科技有限公司 | Benfotiamine polymorphism body, preparation method and application thereof |
| CN111922579A (en) * | 2020-05-29 | 2020-11-13 | 西安航天精密机电研究所 | System and method for accurately welding sealing body pole needle and bridge band based on six-axis robot |
-
1960
- 1960-04-05 GB GB12065/60A patent/GB896089A/en not_active Expired
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101654464B (en) * | 2009-07-28 | 2012-05-23 | 华中药业股份有限公司 | Method for synthesizing vitamin B1 phosphatic monoester |
| CN103113405A (en) * | 2012-10-17 | 2013-05-22 | 上海日馨生物科技有限公司 | Benfotiamine polymorphism body, preparation method and application thereof |
| CN103113405B (en) * | 2012-10-17 | 2016-03-02 | 上海日馨生物科技有限公司 | Benfotiamine polymorphs body, preparation method and application thereof |
| US9718846B1 (en) | 2012-10-17 | 2017-08-01 | Shanghai Ri Xin Biotechnology Co., Ltd. | Crystalline polymorphs of benfotiamine, process for preparation and its use thereof |
| USRE49935E1 (en) | 2012-10-17 | 2024-04-23 | Shanghai Raising Pharmaceutical Co., Ltd. | Crystalline polymorphs of benfotiamine, process for preparation and its use thereof |
| CN111922579A (en) * | 2020-05-29 | 2020-11-13 | 西安航天精密机电研究所 | System and method for accurately welding sealing body pole needle and bridge band based on six-axis robot |
| CN111922579B (en) * | 2020-05-29 | 2022-04-12 | 西安航天精密机电研究所 | System and method for accurately welding sealing body pole needle and bridge band based on six-axis robot |
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