GB938321A - ªá-aminoarylmethylpenicillins - Google Patents

ªá-aminoarylmethylpenicillins

Info

Publication number
GB938321A
GB938321A GB11080/62A GB1108062A GB938321A GB 938321 A GB938321 A GB 938321A GB 11080/62 A GB11080/62 A GB 11080/62A GB 1108062 A GB1108062 A GB 1108062A GB 938321 A GB938321 A GB 938321A
Authority
GB
United Kingdom
Prior art keywords
amino
prepared
acid
tertiary amine
amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB11080/62A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of GB938321A publication Critical patent/GB938321A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
    • C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

a -Amino-arylmethylpenicillins may be prepared by contacting an acid addition salt of an a -aminoarylacetyl halide in a non-aqueous liquid organic solvent medium either with 6-amine-penicillanic acid and a tertiary amine or with a tertiary amine salt of 6-aminopenicillanic acid. Examples are directed mainly to the production of D(-)- and DL-a -amino-benzylpenicillin. D(-)- and DL-2-phenylglycylchloride hydrochloride may be prepared from D(-)-and DL-phenylglycine respectively by reaction with phosphorus pentachloride. Specification 873,049 is referred to.
GB11080/62A 1961-03-23 1962-03-22 ªá-aminoarylmethylpenicillins Expired GB938321A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9776861A 1961-03-23 1961-03-23

Publications (1)

Publication Number Publication Date
GB938321A true GB938321A (en) 1963-10-02

Family

ID=22265034

Family Applications (1)

Application Number Title Priority Date Filing Date
GB11080/62A Expired GB938321A (en) 1961-03-23 1962-03-22 ªá-aminoarylmethylpenicillins

Country Status (6)

Country Link
BR (1) BR6237431D0 (en)
CH (1) CH395097A (en)
DK (1) DK132797C (en)
ES (1) ES275555A1 (en)
GB (1) GB938321A (en)
SE (1) SE302125B (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4240960A (en) * 1979-03-19 1980-12-23 Bristol-Myers Company Trimethylsilyl substituted penicillins
US4278600A (en) 1979-03-19 1981-07-14 Bristol-Myers Company Production of penicillins
US4310458A (en) 1979-03-19 1982-01-12 Bristol-Myers Company Production of penicillins
US4351766A (en) * 1979-07-12 1982-09-28 Bristol-Myers Company Production of penicillins
EP0197294A2 (en) 1985-03-16 1986-10-15 Bayer Ag Beta-lactam antibiotics, process for their preparation and their use as medicaments
US4748163A (en) * 1985-03-08 1988-05-31 Bayer Aktiengesellschaft Novel β-lactam antibiotics

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4240960A (en) * 1979-03-19 1980-12-23 Bristol-Myers Company Trimethylsilyl substituted penicillins
US4278600A (en) 1979-03-19 1981-07-14 Bristol-Myers Company Production of penicillins
US4310458A (en) 1979-03-19 1982-01-12 Bristol-Myers Company Production of penicillins
US4351766A (en) * 1979-07-12 1982-09-28 Bristol-Myers Company Production of penicillins
US4748163A (en) * 1985-03-08 1988-05-31 Bayer Aktiengesellschaft Novel β-lactam antibiotics
USRE33948E (en) * 1985-03-08 1992-06-02 Bayer Aktiengesellschaft β-lactam antibiotics
EP0197294A2 (en) 1985-03-16 1986-10-15 Bayer Ag Beta-lactam antibiotics, process for their preparation and their use as medicaments
US4734407A (en) * 1985-03-16 1988-03-29 Bayer Aktiengesellschaft Alpha-aminoacyl-penicillins and cephalosporins

Also Published As

Publication number Publication date
SE302125B (en) 1968-07-08
BR6237431D0 (en) 1973-05-17
CH395097A (en) 1965-07-15
ES275555A1 (en) 1962-05-16
DK132797C (en) 1976-07-12
DK132797B (en) 1976-02-09

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