GB721477A - 4-aminobenzoic acid ester compounds of penicillin - Google Patents
4-aminobenzoic acid ester compounds of penicillinInfo
- Publication number
- GB721477A GB721477A GB8190/52A GB819052A GB721477A GB 721477 A GB721477 A GB 721477A GB 8190/52 A GB8190/52 A GB 8190/52A GB 819052 A GB819052 A GB 819052A GB 721477 A GB721477 A GB 721477A
- Authority
- GB
- United Kingdom
- Prior art keywords
- penicillin
- salt
- aminobenzoic acid
- general formula
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Penicillin compounds of general formula <FORM:0721477/IV (b)/1> in which R represents an amino group or a lower alkyl group containing up to 3 carbon atoms and Pc represents penicillin in the acid form, are prepared by reacting a salt of a basic ester of a substituted 4-aminobenzoic acid of general formula <FORM:0721477/IV (b)/2> in which R has the meaning above, with a salt of penicillin using water as a solvent, or by reacting the free basic ester of a substituted 4-aminobenzoic acid of the above formula with the free penicillin acid in the presence of an organic solvent. The penicillin salt may be the sodium salt, and the basic ester salt the hydrochloride. Specified organic solvents are ether, ethyl acetate, butyl acetate or mixtures thereof. Examples describe the preparation of penicillin compounds of the above general formula wherein R is (a) amino, and (b) methyl.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE721477X | 1951-03-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB721477A true GB721477A (en) | 1955-01-05 |
Family
ID=6629745
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB8190/52A Expired GB721477A (en) | 1951-03-30 | 1952-03-31 | 4-aminobenzoic acid ester compounds of penicillin |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB721477A (en) |
-
1952
- 1952-03-31 GB GB8190/52A patent/GB721477A/en not_active Expired
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