GB771151A - Method for the preparation of aminoacyl-anilides - Google Patents
Method for the preparation of aminoacyl-anilidesInfo
- Publication number
- GB771151A GB771151A GB16370/55A GB1637055A GB771151A GB 771151 A GB771151 A GB 771151A GB 16370/55 A GB16370/55 A GB 16370/55A GB 1637055 A GB1637055 A GB 1637055A GB 771151 A GB771151 A GB 771151A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- diethylamino
- omega
- dialkylaminoacetic
- mixed anhydride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Compounds of the formula <FORM:0771151/IV(b)/1> where R1 is hydrogen or methyl and R2 and R3 are alkyl groups of up to 4 carbon atoms, and acid addition salts thereof, are made by reacting 2 : 6-dimethyl aniline or 2 : 4 : 6-trimethyl aniline or a salt thereof with the mixed anhydride of a corresponding dialkylaminoacetic acid and an alkoxy or aralkoxy formic acid. The mixed anhydride may suitably be derived from ethoxy-, propoxy-, butoxy- or benzyloxyformic acid and may conveniently be prepared by reaction of the dialkylaminoacetic acid and a halogeno-formic ester. In examples: (1) the sodium salt of diethylaminoacetic acid is reacted with ethyl chloroformate and the product is treated with 2 : 6-dimethylaniline to give omega-diethylamino-2 : 6-dimethylacetanilide; and (2) 2 : 4 : 6-trimethylaniline is converted to omega - diethylamino - 2 : 4 : 6 - trimethylacetanilide by the process of (1). Specifications 634,072, 634,073, 705,460 and 746,552 are referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE771151X | 1954-06-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB771151A true GB771151A (en) | 1957-03-27 |
Family
ID=20332551
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB16370/55A Expired GB771151A (en) | 1954-06-10 | 1955-06-07 | Method for the preparation of aminoacyl-anilides |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB771151A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3925469A (en) * | 1972-02-28 | 1975-12-09 | Astra Pharma Prod | Tetiary-alkylamino-lower-acyl-xylidide local anaesthetics |
US3988473A (en) * | 1973-06-12 | 1976-10-26 | Astra Pharmaceutical Products, Inc. | Tertiary-alkylamino-lower acyl-xylidide local anaesthetics |
-
1955
- 1955-06-07 GB GB16370/55A patent/GB771151A/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3925469A (en) * | 1972-02-28 | 1975-12-09 | Astra Pharma Prod | Tetiary-alkylamino-lower-acyl-xylidide local anaesthetics |
US3988473A (en) * | 1973-06-12 | 1976-10-26 | Astra Pharmaceutical Products, Inc. | Tertiary-alkylamino-lower acyl-xylidide local anaesthetics |
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