GB923895A - New carboxylic acid amides and process for their manufacture - Google Patents

New carboxylic acid amides and process for their manufacture

Info

Publication number
GB923895A
GB923895A GB2733959A GB2733959A GB923895A GB 923895 A GB923895 A GB 923895A GB 2733959 A GB2733959 A GB 2733959A GB 2733959 A GB2733959 A GB 2733959A GB 923895 A GB923895 A GB 923895A
Authority
GB
United Kingdom
Prior art keywords
amide
reacting
carboxylic acid
hydroxy
hydrolysing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2733959A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Farbwerke Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG, Farbwerke Hoechst AG filed Critical Hoechst AG
Publication of GB923895A publication Critical patent/GB923895A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises compounds of the formulae <FORM:0923895/IV(a)/1> (wherein R and R1 are alkyl groups each containing 2 or 3 carbon atoms, R2 is hydrogen, acetyl or propionyl, R3 is acetyl or propionyl, and R4 is a propyl or isopropyl radical) and their preparation (1) by reacting the corresponding a -acyloxy- or a -hydroxy-carboxylic acids or reactive functional derivatives thereof with the appropriate amine, and, if desired, hydrolysing a resulting a -acyloxy-amide to the corresponding a -hydroxy-amide; or (2) by reacting a corresponding a -amino-carboxylic acid amide with nitrous acid; or (3) by reacting a corresponding a -oxo-carboxylic acid amide or an oxalic acid monoester the other carboxyl group of which is bound as the required acid amide group with an alkyl magnesium halide; or (4) by hydrolysing a compound of the formula <FORM:0923895/IV(a)/2> and if desired acylating the a -hydroxy group. Examples are given. a -Amino-a -ethyl-butyric acid tertiary butylamide is prepared from the corresponding a -bromo compound and ammonia. The amides of the invention, which are stated to have analeptic properties, may be formulated as pharmaceutical compositions in admixture with suitable carriers.
GB2733959A 1958-08-08 1959-08-10 New carboxylic acid amides and process for their manufacture Expired GB923895A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEF26365A DE1124031B (en) 1958-08-08 1958-08-08 Process for the preparation of analeptically effective ª ‡ -Propionoxycarbonsaeurediaethylamiden

Publications (1)

Publication Number Publication Date
GB923895A true GB923895A (en) 1963-04-18

Family

ID=7091994

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2733959A Expired GB923895A (en) 1958-08-08 1959-08-10 New carboxylic acid amides and process for their manufacture

Country Status (4)

Country Link
CH (4) CH412848A (en)
DE (1) DE1124031B (en)
GB (1) GB923895A (en)
NL (1) NL114110C (en)

Also Published As

Publication number Publication date
CH412850A (en) 1966-05-15
DE1124031B (en) 1962-02-22
CH412848A (en) 1966-05-15
CH411830A (en) 1966-04-30
CH412849A (en) 1966-05-15
NL114110C (en)

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