GB742450A - Improvements in or relating to piperazine derivatives and process of preparing the same - Google Patents

Improvements in or relating to piperazine derivatives and process of preparing the same

Info

Publication number
GB742450A
GB742450A GB34948/53A GB3494853A GB742450A GB 742450 A GB742450 A GB 742450A GB 34948/53 A GB34948/53 A GB 34948/53A GB 3494853 A GB3494853 A GB 3494853A GB 742450 A GB742450 A GB 742450A
Authority
GB
United Kingdom
Prior art keywords
piperazine
formate
relating
preparing
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB34948/53A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of GB742450A publication Critical patent/GB742450A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Abstract

l-Monoformylpiperazine is made by reacting piperazine with an alkyl formate. The reaction is preferably carried out at a temperature up to 110 DEG C., e.g. at 50 DEG -110 DEG C., and in a closed system using an alkyl formate wherein the alkyl group has from one to four carbon atoms, such as methyl or ethyl formate. The mol. ratio of piperazine to alkyl formate is preferably at least 1 : 1. When an excess of alkyl formate is present increased amounts of the bis formyl piperazine are formed. Examples are given.
GB34948/53A 1952-12-15 1953-12-15 Improvements in or relating to piperazine derivatives and process of preparing the same Expired GB742450A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US742450XA 1952-12-15 1952-12-15

Publications (1)

Publication Number Publication Date
GB742450A true GB742450A (en) 1955-12-30

Family

ID=22118538

Family Applications (1)

Application Number Title Priority Date Filing Date
GB34948/53A Expired GB742450A (en) 1952-12-15 1953-12-15 Improvements in or relating to piperazine derivatives and process of preparing the same

Country Status (1)

Country Link
GB (1) GB742450A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2958624A (en) * 1958-04-30 1960-11-01 Diamond Alkali Co Method of controlling insect and fungi comprising contacting with a 1, 4-diformyl-2, 5-dimethyl piperazine
EP0394792A1 (en) * 1989-04-27 1990-10-31 Bayer Ag (Meth)acrylic acid derivatives containing formyl piperazine groups

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2958624A (en) * 1958-04-30 1960-11-01 Diamond Alkali Co Method of controlling insect and fungi comprising contacting with a 1, 4-diformyl-2, 5-dimethyl piperazine
EP0394792A1 (en) * 1989-04-27 1990-10-31 Bayer Ag (Meth)acrylic acid derivatives containing formyl piperazine groups
US5068264A (en) * 1989-04-27 1991-11-26 Bayer Aktiengesellschaft Formylpiperazinyl-(meth)acrylic acid derivatives for treatment of collagen

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