DK2953973T3 - Muskarine acetylcholinreceptor-bindemidler og anvendelser deraf - Google Patents
Muskarine acetylcholinreceptor-bindemidler og anvendelser deraf Download PDFInfo
- Publication number
- DK2953973T3 DK2953973T3 DK14703337.7T DK14703337T DK2953973T3 DK 2953973 T3 DK2953973 T3 DK 2953973T3 DK 14703337 T DK14703337 T DK 14703337T DK 2953973 T3 DK2953973 T3 DK 2953973T3
- Authority
- DK
- Denmark
- Prior art keywords
- muscarine
- applications
- acetyl choline
- choline receptor
- receptor binders
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361761136P | 2013-02-05 | 2013-02-05 | |
| US201361961058P | 2013-10-03 | 2013-10-03 | |
| PCT/EP2014/052265 WO2014122183A1 (en) | 2013-02-05 | 2014-02-05 | Muscarinic acetylcholine receptor binding agents and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2953973T3 true DK2953973T3 (da) | 2019-08-12 |
Family
ID=50070546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14703337.7T DK2953973T3 (da) | 2013-02-05 | 2014-02-05 | Muskarine acetylcholinreceptor-bindemidler og anvendelser deraf |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20150368339A1 (da) |
| EP (2) | EP2953973B1 (da) |
| JP (2) | JP2016512954A (da) |
| AU (1) | AU2014214054B2 (da) |
| CA (1) | CA2900147C (da) |
| DK (1) | DK2953973T3 (da) |
| ES (1) | ES2745772T3 (da) |
| PL (1) | PL2953973T3 (da) |
| PT (1) | PT2953973T (da) |
| WO (1) | WO2014122183A1 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201014715D0 (en) | 2010-09-06 | 2010-10-20 | Vib Vzw | Nanobodies stabilizing functional conformational states of GPCRS |
| GB201601690D0 (en) | 2016-01-29 | 2016-03-16 | Heptares Therapeutics Ltd | G proteins |
| US20180244784A1 (en) * | 2017-01-05 | 2018-08-30 | Heman Lap Man CHAO | Vegfr2 antibodies |
| EP3565898A4 (en) * | 2017-01-05 | 2021-05-26 | Helix Biopharma Corp. | CAR-VEGFR-2 IMMUNE CELLS FOR CANCER TREATMENT |
| JP7347899B2 (ja) | 2017-08-09 | 2023-09-20 | オリオンズ バイオサイエンス インコーポレイテッド | Ｃｄ８結合物質 |
| US11873347B2 (en) | 2017-10-31 | 2024-01-16 | Vib Vzw | Antigen-binding chimeric proteins and methods and uses thereof |
| US20220276244A1 (en) | 2019-04-29 | 2022-09-01 | Confo Therapeutics N.V. | Chimeric proteins and methods to screen for compounds and ligands binding to gpcrs |
| WO2021140205A1 (en) | 2020-01-10 | 2021-07-15 | Confo Therapeutics N.V. | Methods for generating antibodies and antibody fragments and libraries comprising same |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2162823T5 (es) | 1992-08-21 | 2010-08-09 | Vrije Universiteit Brussel | Inmunoglobulinas desprovistas de cadenas ligeras. |
| AU6796094A (en) | 1993-04-29 | 1994-11-21 | Raymond Hamers | Production of antibodies or (functionalized) fragments thereof derived from heavy chain immunoglobulins of (camelidae) |
| FR2708622B1 (fr) | 1993-08-02 | 1997-04-18 | Raymond Hamers | Vecteur recombinant contenant une séquence d'un gène de lipoprotéine de structure pour l'expression de séquences de nucléotides. |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| US5721121A (en) | 1995-06-06 | 1998-02-24 | Genentech, Inc. | Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein |
| CA2258518C (en) | 1996-06-27 | 2011-11-22 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Recognition molecules interacting specifically with the active site or cleft of a target molecule |
| EP1051493A2 (en) | 1998-01-26 | 2000-11-15 | Unilever Plc | Method for producing antibody fragments |
| BR9916765A (pt) | 1999-01-05 | 2001-09-25 | Unilever Nv | Processo para produzir um material imunoadsorvente, uso de uma proteìna que é ligada por meio de uma ligação covalente a um fragmento de anticorpo, material imunadsorvente, uso de um material, e, kit de teste diagnóstico |
| ATE276359T1 (de) | 1999-01-19 | 2004-10-15 | Unilever Nv | Verfahren zur herstellung von antikörperfragmenten |
| WO2000065057A1 (en) | 1999-04-22 | 2000-11-02 | Unilever Plc | Inhibition of viral infection using monovalent antigen-binding proteins |
| US6479280B1 (en) | 1999-09-24 | 2002-11-12 | Vlaams Interuniversitair Institutuut Voor Biotechnologie Vzw | Recombinant phages capable of entering host cells via specific interaction with an artificial receptor |
| AU2161501A (en) | 1999-11-29 | 2001-06-25 | Unilever Plc | Immobilized single domain antigen-binding molecules |
| AU1859201A (en) | 1999-11-29 | 2001-06-12 | Unilever Plc | Immobilisation of proteins |
| EP1134231B1 (en) | 2000-03-14 | 2009-04-15 | Unilever N.V. | Antibody heavy chain variable domains against human dietary lipases, and their uses |
| AU2001268855A1 (en) | 2000-05-26 | 2001-12-03 | National Research Council Of Canada | Single-domain antigen-binding antibody fragments derived from llama antibodies |
| DK1360207T3 (da) | 2000-12-13 | 2011-09-05 | Bac Ip B V | Proteinarray af variable domæner af tunge immunoglobulinkæder fra kameler |
| GB0110029D0 (en) | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
| WO2003025020A1 (fr) | 2001-09-13 | 2003-03-27 | Institute For Antibodies Co., Ltd. | Procede pour creer une banque d'anticorps de chameaux |
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| US20050037358A1 (en) | 2001-12-21 | 2005-02-17 | Serge Muyldermans | Method for cloning of variable domain sequences |
| EP1461085A2 (en) | 2002-01-03 | 2004-09-29 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Immunoconjugates useful for treatment of tumours |
| AU2003286003B2 (en) | 2002-11-08 | 2011-05-26 | Ablynx N.V. | Stabilized single domain antibodies |
| WO2005044858A1 (en) | 2003-11-07 | 2005-05-19 | Ablynx N.V. | Camelidae single domain antibodies vhh directed against epidermal growth factor receptor and uses therefor |
| JP2006524036A (ja) | 2002-11-08 | 2006-10-26 | アブリンクス エン．ヴェー． | 腫瘍壊死因子αを標的とする単一ドメイン抗体およびその使用 |
| GB0228210D0 (en) | 2002-12-03 | 2003-01-08 | Babraham Inst | Single chain antibodies |
| US7432330B2 (en) | 2002-12-31 | 2008-10-07 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
| EP2390270A1 (en) | 2003-01-10 | 2011-11-30 | Ablynx N.V. | Therapeutic polypeptides, homologues thereof, fragments thereof and for use in modulating platelet-mediated aggregation |
| WO2006040153A2 (en) | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease |
| EP1844073A1 (en) | 2005-01-31 | 2007-10-17 | Ablynx N.V. | Method for generating variable domain sequences of heavy chain antibodies |
| AU2006249144B2 (en) | 2005-05-18 | 2011-11-17 | Ablynx Nv | Improved NanobodiesTM against Tumor Necrosis Factor-alpha |
| NZ563392A (en) | 2005-05-20 | 2009-12-24 | Ablynx Nv | Improved Nanobodies(TM) for the treatment of aggregation-mediated disorders |
| US8629244B2 (en) | 2006-08-18 | 2014-01-14 | Ablynx N.V. | Interleukin-6 receptor binding polypeptides |
| CN101663319A (zh) | 2007-02-21 | 2010-03-03 | 埃博灵克斯股份有限公司 | 针对血管内皮生长因子的氨基酸序列和包括其的多肽用于治疗特征在于过量和/或病理性血管发生或新血管形成的病症和疾病 |
| CN104231082B (zh) | 2007-05-24 | 2018-12-21 | 埃博灵克斯股份有限公司 | 用于治疗骨疾病和病症的针对rank-l的氨基酸序列以及包括其的多肽 |
| CA2749558C (en) | 2008-12-08 | 2019-01-15 | Complix Nv | Single-chain antiparallel coiled coil proteins |
| WO2010070145A2 (en) | 2008-12-19 | 2010-06-24 | Ablynx N.V. | Method for generation of immunoglobulin sequences |
| WO2011083140A1 (en) | 2010-01-08 | 2011-07-14 | Ablynx Nv | Immunoglobulin single variable domain directed against human cxcr4 |
| GB201014715D0 (en) * | 2010-09-06 | 2010-10-20 | Vib Vzw | Nanobodies stabilizing functional conformational states of GPCRS |
| US8470561B2 (en) | 2010-08-30 | 2013-06-25 | ConfometRX Inc. | GPCR comprising an IC2 insertion |
| US8765414B2 (en) | 2011-03-15 | 2014-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | GPCR fusion protein containing an N-terminal autonomously folding stable domain, and crystals of the same |
| WO2012158555A2 (en) | 2011-05-13 | 2012-11-22 | Receptos, Inc. | Novel fusion partners for the purpose of crystallizing g-protein coupled receptors |
| CA2899693C (en) * | 2013-01-30 | 2023-03-14 | Vib Vzw | Novel chimeric polypeptides for screening and drug discovery purposes |
-
2014
- 2014-02-05 PT PT147033377T patent/PT2953973T/pt unknown
- 2014-02-05 AU AU2014214054A patent/AU2014214054B2/en active Active
- 2014-02-05 CA CA2900147A patent/CA2900147C/en active Active
- 2014-02-05 EP EP14703337.7A patent/EP2953973B1/en active Active
- 2014-02-05 DK DK14703337.7T patent/DK2953973T3/da active
- 2014-02-05 US US14/765,824 patent/US20150368339A1/en not_active Abandoned
- 2014-02-05 WO PCT/EP2014/052265 patent/WO2014122183A1/en active Application Filing
- 2014-02-05 PL PL14703337T patent/PL2953973T3/pl unknown
- 2014-02-05 EP EP19184955.3A patent/EP3590578A1/en active Pending
- 2014-02-05 ES ES14703337T patent/ES2745772T3/es active Active
- 2014-02-05 JP JP2015555753A patent/JP2016512954A/ja active Pending
-
2018
- 2018-03-29 US US15/939,748 patent/US20180222978A1/en not_active Abandoned
-
2019
- 2019-02-22 JP JP2019030146A patent/JP6827485B2/ja active Active
-
2021
- 2021-07-02 US US17/366,755 patent/US20210340249A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014122183A9 (en) | 2016-05-26 |
| EP2953973B1 (en) | 2019-07-10 |
| AU2014214054A1 (en) | 2015-08-20 |
| PL2953973T3 (pl) | 2020-01-31 |
| WO2014122183A1 (en) | 2014-08-14 |
| JP2016512954A (ja) | 2016-05-12 |
| US20150368339A1 (en) | 2015-12-24 |
| CA2900147A1 (en) | 2014-08-14 |
| EP2953973A1 (en) | 2015-12-16 |
| PT2953973T (pt) | 2019-10-25 |
| JP2019122378A (ja) | 2019-07-25 |
| AU2014214054B2 (en) | 2018-10-04 |
| US20210340249A1 (en) | 2021-11-04 |
| ES2745772T3 (es) | 2020-03-03 |
| CA2900147C (en) | 2023-09-05 |
| US20180222978A1 (en) | 2018-08-09 |
| EP3590578A1 (en) | 2020-01-08 |
| JP6827485B2 (ja) | 2021-02-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3411065T3 (da) | Clec9a-bindingsmidler | |
| DK2951183T3 (da) | Spiro-lactam-nmda-receptormodulatorer og anvendelser heraf | |
| DK2970460T3 (da) | Anti-IL-33-antistoffer og anvendelser deraf | |
| DK3043784T3 (da) | Arylethere og anvendelser deraf | |
| DK3016946T3 (da) | Substituerede benzofuranyl- og benzoxazolylforbindelser og anvendelser deraf | |
| DK3089994T3 (da) | Fabs-in-tandem-immunglobulin og anvendelser deraf | |
| DK3027209T3 (da) | Anti-Activin A-antistoffer og anvendelser deraf | |
| DK3043803T3 (da) | Nukleotid- og nucleosidsammensætninger og deres anvendelse | |
| DK2968443T3 (da) | Hepcidinanaloger og anvendelser deraf | |
| DK3199552T3 (da) | Anti-ceacam5-antistoffer og anvendelser heraf | |
| DK2953973T3 (da) | Muskarine acetylcholinreceptor-bindemidler og anvendelser deraf | |
| DK3003039T3 (da) | Methyl/fluor-pyridinyl-metoxy-substituerede pyridinon-pyridinyl-forbindelser og fluor-pyrimidinyl-metoxy-substituerede pyridinon-pyridinyl-forbindelser | |
| DK3063144T3 (da) | Antiparasitære og pesticid-isoxazolinforbindelser | |
| DK2962100T3 (da) | Tuberkulosebiomarkører og anvendelser deraf | |
| DK3030549T3 (da) | Pyridazinonforbindelser og anvendelser deraf | |
| BR302013003671S1 (pt) | Configuração aplicada em suporte | |
| UY4332S (es) | Soporte | |
| UY4367S (es) | Soporte para altavoz | |
| DK2864359T3 (da) | Anti-cd26-antistoffer og anvendelser deraf | |
| DK2956476T3 (da) | Ligandbindende molekyler og anvendelser deraf | |
| DK2978775T3 (da) | Termisk modificeret stivelse | |
| DK3077510T3 (da) | Antisense-forbindelser og anvendelser deraf | |
| BR302013003828S1 (pt) | Configuração aplicada em suporte | |
| DK3027068T3 (da) | Pressesystem | |
| DK3283571T3 (da) | Klart bindemiddel og anvendelser deraf |