WO2009057664A1 - 抗体及びその利用 - Google Patents

抗体及びその利用 Download PDF

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Publication number
WO2009057664A1
WO2009057664A1 PCT/JP2008/069696 JP2008069696W WO2009057664A1 WO 2009057664 A1 WO2009057664 A1 WO 2009057664A1 JP 2008069696 W JP2008069696 W JP 2008069696W WO 2009057664 A1 WO2009057664 A1 WO 2009057664A1
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WO
WIPO (PCT)
Prior art keywords
reactivity
antibody
amyloid
amylospheroid
protein
Prior art date
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PCT/JP2008/069696
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English (en)
French (fr)
Inventor
Minako Hoshi
Michio Sato
Shoji Ideno
Koji Naito
Satoshi Horie
Munehiro Noda
Hajime Horii
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Mitsubishi Chemical Corporation
Mitsubishi Tanabe Pharma Corporation
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Filing date
Publication date
Application filed by Mitsubishi Chemical Corporation, Mitsubishi Tanabe Pharma Corporation filed Critical Mitsubishi Chemical Corporation
Priority to EP08844261.1A priority Critical patent/EP2224000B1/en
Priority to JP2009539096A priority patent/JP5185946B2/ja
Priority to CN200880113862.8A priority patent/CN101878301B/zh
Priority to US12/734,359 priority patent/US8445649B2/en
Publication of WO2009057664A1 publication Critical patent/WO2009057664A1/ja
Priority to HK11104163.0A priority patent/HK1150061A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

　本発明は、アミロイド前駆蛋白質に対する反応性が低く、かつアミロスフェロイドに対する反応性が、アミロイドβ線維またはアミロイドβモノマー蛋白質に対する反応性よりも高い抗体等を提供することを目的とする。本発明によれば、アミロスフェロイドに対する反応性が、アミロイド前駆蛋白質に対する反応性よりも高く、かつ以下の何れか１以上の特徴を有する抗体が提供される。（i）アミロスフェロイドに対する反応性が、アミロイドβ線維に対する反応性よりも高い；（ii）アミロスフェロイドに対する反応性が、アミロイドβモノマー蛋白質に対する反応性よりも高い；（iii）アミロスフェロイドによる神経細胞死誘導に対する阻害活性を有する。
PCT/JP2008/069696 2007-10-29 2008-10-29 抗体及びその利用 WO2009057664A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP08844261.1A EP2224000B1 (en) 2007-10-29 2008-10-29 Antibody and use thereof
JP2009539096A JP5185946B2 (ja) 2007-10-29 2008-10-29 抗体及びその利用
CN200880113862.8A CN101878301B (zh) 2007-10-29 2008-10-29 抗体及其应用
US12/734,359 US8445649B2 (en) 2007-10-29 2008-10-29 Antibody and use thereof
HK11104163.0A HK1150061A1 (en) 2007-10-29 2011-04-26 Antibody and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007280187 2007-10-29
JP2007-280187 2007-10-29

Publications (1)

Publication Number Publication Date
WO2009057664A1 true WO2009057664A1 (ja) 2009-05-07

Family

ID=40591051

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/069696 WO2009057664A1 (ja) 2007-10-29 2008-10-29 抗体及びその利用

Country Status (6)

Country Link
US (1) US8445649B2 (ja)
EP (1) EP2224000B1 (ja)
JP (3) JP5185946B2 (ja)
CN (2) CN104098695B (ja)
HK (2) HK1150061A1 (ja)
WO (1) WO2009057664A1 (ja)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013523182A (ja) * 2010-04-15 2013-06-17 アボット・ラボラトリーズ アミロイドベータ結合タンパク質
WO2013094614A1 (ja) 2011-12-22 2013-06-27 Ｔａｏヘルスライフファーマ株式会社 合成アミロスフェロイドの製造方法
WO2013099806A1 (ja) 2011-12-29 2013-07-04 Ｔａｏヘルスライフファーマ株式会社 アミロスフェロイドが結合して成熟神経細胞死を誘発する標的分子、アミロスフェロイドが誘導する神経細胞死を抑制する方法及び物質、及びそれらの利用
WO2015111430A1 (ja) * 2014-01-21 2015-07-30 株式会社 島津製作所 Ａｐｐ切断型ペプチドの測定方法
JP2015536645A (ja) * 2012-10-15 2015-12-24 メディミューン リミテッド アミロイドβに対する抗体
JP2019038806A (ja) * 2011-12-29 2019-03-14 Ｔａｏヘルスライフファーマ株式会社 アミロスフェロイドが結合して成熟神経細胞死を誘発する標的分子、アミロスフェロイドが誘導する神経細胞死を抑制する方法及び物質、及びそれらの利用
WO2021100744A1 (ja) 2019-11-19 2021-05-27 Ｔａｏヘルスライフファーマ株式会社 アミロスフェロイド（ＡＳＰＤ）の代替物となりうるアミロイドβタンパク質（Ａβ）の架橋体、及びＡＳＰＤの分析
CN114478762A (zh) * 2022-02-15 2022-05-13 武汉天德生物科技有限公司 一种β-淀粉样多肽1-42单克隆抗体、ELISA试剂盒及其应用

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AR085302A1 (es) 2011-02-24 2013-09-18 Sanofi Sa Metodo de produccion de anticuerpos sialilados
WO2017179646A1 (ja) * 2016-04-14 2017-10-19 Ｔａｏヘルスライフファーマ株式会社 アミロスフェロイド（ａｓｐｄ）様構造体及び医薬組成物

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JP2020103288A (ja) * 2010-04-15 2020-07-09 アッヴィ・インコーポレイテッド アミロイドベータ結合タンパク質
JP2018058837A (ja) * 2010-04-15 2018-04-12 アッヴィ・インコーポレイテッド アミロイドベータ結合タンパク質
JP2016028030A (ja) * 2010-04-15 2016-02-25 アッヴィ・インコーポレイテッド アミロイドベータ結合タンパク質
JP2013523182A (ja) * 2010-04-15 2013-06-17 アボット・ラボラトリーズ アミロイドベータ結合タンパク質
WO2013094614A1 (ja) 2011-12-22 2013-06-27 Ｔａｏヘルスライフファーマ株式会社 合成アミロスフェロイドの製造方法
US8946327B2 (en) 2011-12-22 2015-02-03 Tao Health Life Pharma Co., Ltd. Method for producing synthetic amylospheroid
JP2018058838A (ja) * 2011-12-29 2018-04-12 Ｔａｏヘルスライフファーマ株式会社 アミロスフェロイドが結合して成熟神経細胞死を誘発する標的分子、アミロスフェロイドが誘導する神経細胞死を抑制する方法及び物質、及びそれらの利用
JP2015214557A (ja) * 2011-12-29 2015-12-03 Ｔａｏヘルスライフファーマ株式会社 アミロスフェロイドが結合して成熟神経細胞死を誘発する標的分子、アミロスフェロイドが誘導する神経細胞死を抑制する方法及び物質、及びそれらの利用
JP2019038806A (ja) * 2011-12-29 2019-03-14 Ｔａｏヘルスライフファーマ株式会社 アミロスフェロイドが結合して成熟神経細胞死を誘発する標的分子、アミロスフェロイドが誘導する神経細胞死を抑制する方法及び物質、及びそれらの利用
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CN110075111A (zh) * 2011-12-29 2019-08-02 道健康生活医药株式会社 针对淀粉样蛋白球体发生竞争阻断的物质的用途及候补化合物的筛选方法
US9751912B2 (en) 2011-12-29 2017-09-05 Tao Health Life Pharma Co., Ltd. Neurotoxic target for amylospheroid, method and material for reducing the neurotoxicity of amylospheroid, and use thereof
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JP2020099340A (ja) * 2012-10-15 2020-07-02 メディミューン リミテッド アミロイドβに対する抗体
JPWO2015111430A1 (ja) * 2014-01-21 2017-03-23 株式会社島津製作所 Ａｐｐ切断型ペプチドの測定方法
WO2015111430A1 (ja) * 2014-01-21 2015-07-30 株式会社 島津製作所 Ａｐｐ切断型ペプチドの測定方法
US10942190B2 (en) 2014-01-21 2021-03-09 Shimadzu Corporation Measurement method for amyloid precursor protein cleavage peptides
WO2021100744A1 (ja) 2019-11-19 2021-05-27 Ｔａｏヘルスライフファーマ株式会社 アミロスフェロイド（ＡＳＰＤ）の代替物となりうるアミロイドβタンパク質（Ａβ）の架橋体、及びＡＳＰＤの分析
JPWO2021100744A1 (ja) * 2019-11-19 2021-05-27
JP7383043B2 (ja) 2019-11-19 2023-11-17 公益財団法人神戸医療産業都市推進機構 アミロスフェロイド（ＡＳＰＤ）の代替物となりうるアミロイドβタンパク質（Ａβ）の架橋体、及びＡＳＰＤの分析
CN114478762A (zh) * 2022-02-15 2022-05-13 武汉天德生物科技有限公司 一种β-淀粉样多肽1-42单克隆抗体、ELISA试剂盒及其应用
CN114478762B (zh) * 2022-02-15 2024-06-04 武汉天德生物科技有限公司 一种β-淀粉样多肽1-42单克隆抗体、ELISA试剂盒及其应用

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HK1203206A1 (en) 2015-10-23
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