CN115362171A - 用于治疗冠状病毒的抗体、融合蛋白及其应用 - Google Patents
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- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
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Abstract
本发明提供用于治疗冠状病毒的抗体、融合蛋白及其应用。本发明融合蛋白中6‑HB干扰多肽与抗体部分或抗原结合片段协同阻止SARS‑CoV或SARS‑CoV‑2病毒颗粒和细胞融合，以及介导免疫细胞吞噬、清除病毒颗粒。
Description
PCT国内申请，说明书已公开。
Claims (21)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020102448944 | 2020-03-31 | ||
| CN202010244894 | 2020-03-31 | ||
| CN2020102870372 | 2020-04-13 | ||
| CN2020102869869 | 2020-04-13 | ||
| CN202010287037 | 2020-04-13 | ||
| CN202010286986 | 2020-04-13 | ||
| CN202010344572.7A CN113637070A (zh) | 2020-04-27 | 2020-04-27 | 抗spike蛋白的抗体或抗原结合片段及其应用 |
| CN202010344084.6A CN113637083A (zh) | 2020-04-27 | 2020-04-27 | 用于治疗冠状病毒的融合蛋白及其应用 |
| CN2020103445727 | 2020-04-27 | ||
| CN2020103440846 | 2020-04-27 | ||
| CN202010784365 | 2020-08-06 | ||
| CN2020107843653 | 2020-08-06 | ||
| PCT/CN2021/084069 WO2021197340A1 (zh) | 2020-03-31 | 2021-03-30 | 用于治疗冠状病毒的抗体、融合蛋白及其应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115362171A true CN115362171A (zh) | 2022-11-18 |
Family
ID=77927385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180025566.8A Pending CN115362171A (zh) | 2020-03-31 | 2021-03-30 | 用于治疗冠状病毒的抗体、融合蛋白及其应用 |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP4130035A1 (zh) |
| CN (1) | CN115362171A (zh) |
| WO (1) | WO2021197340A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115746148B (zh) * | 2022-10-14 | 2023-09-12 | 中国医学科学院病原生物学研究所 | 具有冠状病毒rbd和膜融合抑制多肽的蛋白质及其作为冠状病毒抑制剂的应用 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
| US4716111A (en) | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4694778A (en) | 1984-05-04 | 1987-09-22 | Anicon, Inc. | Chemical vapor deposition wafer boat |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
| US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5413923A (en) | 1989-07-25 | 1995-05-09 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| EP0546073B1 (en) | 1990-08-29 | 1997-09-10 | GenPharm International, Inc. | production and use of transgenic non-human animals capable of producing heterologous antibodies |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
| IE922437A1 (en) | 1991-07-25 | 1993-01-27 | Idec Pharma Corp | Recombinant antibodies for human therapy |
| US5756096A (en) | 1991-07-25 | 1998-05-26 | Idec Pharmaceuticals Corporation | Recombinant antibodies for human therapy |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US6130364A (en) | 1995-03-29 | 2000-10-10 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
| EP1978033A3 (en) | 1995-04-27 | 2008-12-24 | Amgen Fremont Inc. | Human antibodies derived from immunized xenomice |
| CA2219486A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6420140B1 (en) | 1996-10-11 | 2002-07-16 | Abgenix, Inc. | Production of multimeric protein by cell fusion method |
| US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| ES2301183T3 (es) | 1996-12-03 | 2008-06-16 | Amgen Fremont Inc. | Anticuerpo completamente humano que se une al receptor del egfr. |
| RU2224766C2 (ru) | 1997-04-14 | 2004-02-27 | Микромет Аг | Способ получения рецепторов для человеческих антигенов и их применение |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| EP0983303B1 (en) | 1997-05-21 | 2006-03-08 | Biovation Limited | Method for the production of non-immunogenic proteins |
| WO2000034317A2 (en) | 1998-12-08 | 2000-06-15 | Biovation Limited | Method for reducing immunogenicity of proteins |
| DK2193802T3 (da) * | 2005-02-08 | 2012-06-25 | New York Blood Ct Inc | Neutraliserende monoklonale antistoffer mod med svært akut respirationssyndrom associeret coronavirus |
| CN1884303A (zh) * | 2005-06-20 | 2006-12-27 | 中国医学科学院基础医学研究所 | SARS－CoV病毒结构蛋白的融合蛋白及其高量表达与纯化和用途 |
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2021
- 2021-03-30 CN CN202180025566.8A patent/CN115362171A/zh active Pending
- 2021-03-30 WO PCT/CN2021/084069 patent/WO2021197340A1/zh unknown
- 2021-03-30 EP EP21780300.6A patent/EP4130035A1/en active Pending
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|---|---|
| WO2021197340A1 (zh) | 2021-10-07 |
| EP4130035A1 (en) | 2023-02-08 |
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