JP2003192699A - トランスジェニック動物からの抗体の生産 - Google Patents
トランスジェニック動物からの抗体の生産Info
- Publication number
- JP2003192699A JP2003192699A JP2002314611A JP2002314611A JP2003192699A JP 2003192699 A JP2003192699 A JP 2003192699A JP 2002314611 A JP2002314611 A JP 2002314611A JP 2002314611 A JP2002314611 A JP 2002314611A JP 2003192699 A JP2003192699 A JP 2003192699A
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- Prior art keywords
- immunoglobulin
- animal
- human
- dna
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Genetics & Genomics (AREA)
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- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Environmental Sciences (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
(57)【要約】
【課題】 ヒトでの使用に適する可能性のある治療上有
益な免疫グロブリンを、ヒト以外のトランスジェニック
動物を用いて生産する。 【解決手段】 ヒト由来免疫グロブリンのＨ鎖領域をコ
ードする遺伝子セグメントを含み、ヒト由来の免疫グロ
ブリンの少なくとも一部をコードする外来ＤＮＡを、ヒ
ト以外の動物の生殖系列内に導入することにより、ヒト
以外のトランスジェニック動物を生産し、それにより、
このトランスジェニック動物を特定の抗原で攻撃するこ
とに続いて、この再配列または変異されたＤＮＡにコー
ドされたこの特定の抗原に対するこの免疫グロブリンを
この動物の細胞内または体液内において発現させるステ
ップと、この動物の細胞または適当な体液から免疫グロ
ブリンを得るステップと、を備える、特定の抗原に対す
る免疫グロブリンを生産する方法。
益な免疫グロブリンを、ヒト以外のトランスジェニック
動物を用いて生産する。 【解決手段】 ヒト由来免疫グロブリンのＨ鎖領域をコ
ードする遺伝子セグメントを含み、ヒト由来の免疫グロ
ブリンの少なくとも一部をコードする外来ＤＮＡを、ヒ
ト以外の動物の生殖系列内に導入することにより、ヒト
以外のトランスジェニック動物を生産し、それにより、
このトランスジェニック動物を特定の抗原で攻撃するこ
とに続いて、この再配列または変異されたＤＮＡにコー
ドされたこの特定の抗原に対するこの免疫グロブリンを
この動物の細胞内または体液内において発現させるステ
ップと、この動物の細胞または適当な体液から免疫グロ
ブリンを得るステップと、を備える、特定の抗原に対す
る免疫グロブリンを生産する方法。
Description
【０００１】
【発明の分野】この発明は抗体（または免疫グロブリ
ン）の生産に関するものである。
ン）の生産に関するものである。
【０００２】
【発明の概要】この発明の１つの局面に従えば、外来起
源の免疫グロブリンの少なくとも一部をコードするかま
たは免疫グロブリンのレパートリーをコードするために
再配列し得る遺伝物質をその生殖系列に挿入されたトラ
ンスジェニック動物の細胞または体液から免疫グロブリ
ンを得ることを含む、免疫グロブリンを生産する方法が
提供される。
源の免疫グロブリンの少なくとも一部をコードするかま
たは免疫グロブリンのレパートリーをコードするために
再配列し得る遺伝物質をその生殖系列に挿入されたトラ
ンスジェニック動物の細胞または体液から免疫グロブリ
ンを得ることを含む、免疫グロブリンを生産する方法が
提供される。
【０００３】外来起源の免疫グロブリンは、異なった動
物源から誘導される免疫グロブリンを意味する。たとえ
ばトランスジェニック動物がマウスの場合、挿入される
遺伝物質は、たとえばヒトのようなマウス以外の起源の
ものである。
物源から誘導される免疫グロブリンを意味する。たとえ
ばトランスジェニック動物がマウスの場合、挿入される
遺伝物質は、たとえばヒトのようなマウス以外の起源の
ものである。
【０００４】挿入される遺伝物質は、動物源から生産さ
れてもよく、または人工合成により生産されてもよい。
材料は、知られた免疫グロブリンの少なくとも一部をコ
ードしてもよく、または改変された免疫グロブリンの少
なくとも一部をコードするよう修飾されてもよい。これ
らのプロセスのための適当な技術はよく知られている。
れてもよく、または人工合成により生産されてもよい。
材料は、知られた免疫グロブリンの少なくとも一部をコ
ードしてもよく、または改変された免疫グロブリンの少
なくとも一部をコードするよう修飾されてもよい。これ
らのプロセスのための適当な技術はよく知られている。
【０００５】挿入された遺伝物質はトランスジェニック
動物において発現することができ、少なくとも一部は挿
入された材料から誘導される免疫グロブリンの生産をも
たらす。遺伝物質はトランスジェニック動物において再
配列され、それにより、たとえ挿入された遺伝物質が生
殖系列において間違った位置にまたは間違った形態構造
で組込まれたとしても、挿入された遺伝物質からの一つ
の部分または複数の部分で免疫グロブリンのレパートリ
ーが生産され得ることが見出された。挿入された物質の
性質によって、動物は、たとえば混合されたマウス／ヒ
ト起源のキメラの免疫グロブリンを生産し得、そこでは
外来起源の遺伝物質は免疫グロブリンの一部だけをコー
ドする。あるいは動物は、たとえばまったくヒト起源
の、完全に外来の免疫グロブリンを生産し得、そこでは
外来起源の遺伝物質は、免疫グロブリン全体をコードす
る。ヒトでの使用に適する可能性のある治療上有益な免
疫グロブリンは、こうしてこの発明の使用によって生産
できる。
動物において発現することができ、少なくとも一部は挿
入された材料から誘導される免疫グロブリンの生産をも
たらす。遺伝物質はトランスジェニック動物において再
配列され、それにより、たとえ挿入された遺伝物質が生
殖系列において間違った位置にまたは間違った形態構造
で組込まれたとしても、挿入された遺伝物質からの一つ
の部分または複数の部分で免疫グロブリンのレパートリ
ーが生産され得ることが見出された。挿入された物質の
性質によって、動物は、たとえば混合されたマウス／ヒ
ト起源のキメラの免疫グロブリンを生産し得、そこでは
外来起源の遺伝物質は免疫グロブリンの一部だけをコー
ドする。あるいは動物は、たとえばまったくヒト起源
の、完全に外来の免疫グロブリンを生産し得、そこでは
外来起源の遺伝物質は、免疫グロブリン全体をコードす
る。ヒトでの使用に適する可能性のある治療上有益な免
疫グロブリンは、こうしてこの発明の使用によって生産
できる。
【０００６】ポリクローナル抗血清が、免疫感作に続い
てトランスジェニック動物から生産されてもよい。その
代わりに、たとえば骨髄腫細胞と動物からの脾臓細胞を
融合しかつ所望の抗体を生産するものを選択するために
結果として生じたハイブリドーマをふるい分けることに
よって、モノクローナル抗体がトランスジェニック動物
から生産されてもよい。このようなプロセスのための適
当な技術は当業者によく知られている。
てトランスジェニック動物から生産されてもよい。その
代わりに、たとえば骨髄腫細胞と動物からの脾臓細胞を
融合しかつ所望の抗体を生産するものを選択するために
結果として生じたハイブリドーマをふるい分けることに
よって、モノクローナル抗体がトランスジェニック動物
から生産されてもよい。このようなプロセスのための適
当な技術は当業者によく知られている。
【０００７】代替のアプローチにおいて、遺伝物質は、
血清のような体液または乳汁、初乳もしくは唾液のよう
な動物の外部分泌物において所望の抗体が産出されるよ
うに動物に組込まれてもよい。たとえば、外来起源の免
疫グロブリンの少なくとも一部をコードする遺伝物質を
乳タンパク質をコードする哺乳動物の遺伝子にインビト
ロで挿入し、かつそれから、たとえば注入によって、そ
の遺伝子を哺乳動物の受精卵に導入することによって、
その卵は、少なくとも一部は挿入された遺伝物質から誘
導される免疫グロブリンを含む乳汁を生産する成熟した
雌の哺乳動物に発育することができる。次いで所望の抗
体が乳汁から採収できる。このようなプロセスを実施す
るための適当な技術は当業者に知られている。
血清のような体液または乳汁、初乳もしくは唾液のよう
な動物の外部分泌物において所望の抗体が産出されるよ
うに動物に組込まれてもよい。たとえば、外来起源の免
疫グロブリンの少なくとも一部をコードする遺伝物質を
乳タンパク質をコードする哺乳動物の遺伝子にインビト
ロで挿入し、かつそれから、たとえば注入によって、そ
の遺伝子を哺乳動物の受精卵に導入することによって、
その卵は、少なくとも一部は挿入された遺伝物質から誘
導される免疫グロブリンを含む乳汁を生産する成熟した
雌の哺乳動物に発育することができる。次いで所望の抗
体が乳汁から採収できる。このようなプロセスを実施す
るための適当な技術は当業者に知られている。
【０００８】別の可能な方法は、遺伝物質の挿入後動物
によって生成された免疫グロブリン生産細胞を動物から
除去した後、対象の免疫グロブリンを生産する細胞をイ
ンビトロで選択することを含む。次いで免疫グロブリン
は知られた態様において選択された細胞からインビトロ
で生産できる。
によって生成された免疫グロブリン生産細胞を動物から
除去した後、対象の免疫グロブリンを生産する細胞をイ
ンビトロで選択することを含む。次いで免疫グロブリン
は知られた態様において選択された細胞からインビトロ
で生産できる。
【０００９】トランスジェニック動物はその後動物に導
入される免疫原に応答してキメラのまたは外来の免疫グ
ロブリン（挿入された遺伝物質から誘導される）を生産
できるということが発見された。したがって、免疫グロ
ブリンの種特異的な全領域を実質的にコードする外来
の、たとえばヒトの遺伝物質を導入することによって、
動物に導入される任意の抗原に対して外来の免疫グロブ
リンを生産するよう動物を刺激することが可能になり得
る。こうしてトランスジェニック動物は、広範囲の抗原
に対するヒトの免疫グロブリンの非常に有益で、便利で
かつ価値のある源を提供することができるであろう。
入される免疫原に応答してキメラのまたは外来の免疫グ
ロブリン（挿入された遺伝物質から誘導される）を生産
できるということが発見された。したがって、免疫グロ
ブリンの種特異的な全領域を実質的にコードする外来
の、たとえばヒトの遺伝物質を導入することによって、
動物に導入される任意の抗原に対して外来の免疫グロブ
リンを生産するよう動物を刺激することが可能になり得
る。こうしてトランスジェニック動物は、広範囲の抗原
に対するヒトの免疫グロブリンの非常に有益で、便利で
かつ価値のある源を提供することができるであろう。
【００１０】しかしながら、挿入される遺伝物質は、う
まく再配列させるために近接ゲノムに組込まれるという
ことが重要であるかもしれない。そこで、挿入される遺
伝物質はプラスミドおよびコスミドのような原核生物の
ベクタにクローン化されたＤＮＡの形態とすることがで
きる。複数のプラスミドまたはコスミドもまた使用され
てもよく、しかしこれらがゲノム上に近接して組込まれ
ることがおそらく必要である。酵母の人工染色体ベクタ
を使用することによって（１９８７年、バーク（Burk
e)、ＤＴ、カール（Carle)、ＧＦおよびオルソン（Olso
n)、ＭＶの「人工染色体ベクタによる酵母への外因性Ｄ
ＮＡの大きなセグメントのクローニング」(Cloning of
large segments of exogenous DNA into yeast by mean
s of artifical chromosome vectors)サイエンス(Scien
ce) 、２３６号、８０６頁ないし８１２頁を参照）、ま
たは染色体断片の導入によって（リッチャー（Richer)
、ＪおよびＬｏ、ＣＷ、１９８９年「全裂ヒト染色体
断片の注入によるヒトＤＮＡのマウス卵への導入」(Int
roduction of human DNA into mouse eggs by injectio
n of dissected human chromo some fragments) サイエ
ンス（Science)２４５号、１７５頁ないし１７７頁を参
照）、より大きいＤＮＡ断片を挿入することもまた可能
であると判明し得る。
まく再配列させるために近接ゲノムに組込まれるという
ことが重要であるかもしれない。そこで、挿入される遺
伝物質はプラスミドおよびコスミドのような原核生物の
ベクタにクローン化されたＤＮＡの形態とすることがで
きる。複数のプラスミドまたはコスミドもまた使用され
てもよく、しかしこれらがゲノム上に近接して組込まれ
ることがおそらく必要である。酵母の人工染色体ベクタ
を使用することによって（１９８７年、バーク（Burk
e)、ＤＴ、カール（Carle)、ＧＦおよびオルソン（Olso
n)、ＭＶの「人工染色体ベクタによる酵母への外因性Ｄ
ＮＡの大きなセグメントのクローニング」(Cloning of
large segments of exogenous DNA into yeast by mean
s of artifical chromosome vectors)サイエンス(Scien
ce) 、２３６号、８０６頁ないし８１２頁を参照）、ま
たは染色体断片の導入によって（リッチャー（Richer)
、ＪおよびＬｏ、ＣＷ、１９８９年「全裂ヒト染色体
断片の注入によるヒトＤＮＡのマウス卵への導入」(Int
roduction of human DNA into mouse eggs by injectio
n of dissected human chromo some fragments) サイエ
ンス（Science)２４５号、１７５頁ないし１７７頁を参
照）、より大きいＤＮＡ断片を挿入することもまた可能
であると判明し得る。
【００１１】挿入される遺伝物質は、たとえば受精卵ま
たは胚幹細胞への注入または他の方法による従来の態様
で宿主に導入することができる。
たは胚幹細胞への注入または他の方法による従来の態様
で宿主に導入することができる。
【００１２】初めは免疫グロブリンの定常領域をコード
する遺伝物質を持たない宿主動物を使用することが便利
となり得、それにより得られるトランスジェニック動物
は、免疫グロブリンを生産するとき、挿入された外来の
遺伝物質だけを使用するであろう。これは、関連する遺
伝物質を欠く自然に発生した突然変位体宿主を使用する
ことによって、または関連する遺伝物質が取り除かれた
宿主を最後に作るために、突然変位体をたとえば細胞系
において人工的に作ることによってのどちらかで達成さ
れ得る。
する遺伝物質を持たない宿主動物を使用することが便利
となり得、それにより得られるトランスジェニック動物
は、免疫グロブリンを生産するとき、挿入された外来の
遺伝物質だけを使用するであろう。これは、関連する遺
伝物質を欠く自然に発生した突然変位体宿主を使用する
ことによって、または関連する遺伝物質が取り除かれた
宿主を最後に作るために、突然変位体をたとえば細胞系
において人工的に作ることによってのどちらかで達成さ
れ得る。
【００１３】宿主動物が免疫グロブリン定常領域をコー
ドする遺伝物質を持つ場合、トランスジェニック動物
は、本来生じる遺伝物質および挿入された遺伝物質を持
つであろうし、かつ本来生じる遺伝物質、挿入された遺
伝物質および遺伝物質の両方の型の混合物から誘導され
る免疫グロブリンを生産するであろう。この場合におい
て、所望の免疫グロブリンは、トランスジェニック動物
から誘導されるハイブリドーマをふるい分けることによ
って、たとえば示差的染色体喪失または抗体遺伝子発現
の対立遺伝子排除の現象を活用することによって得るこ
とができる。
ドする遺伝物質を持つ場合、トランスジェニック動物
は、本来生じる遺伝物質および挿入された遺伝物質を持
つであろうし、かつ本来生じる遺伝物質、挿入された遺
伝物質および遺伝物質の両方の型の混合物から誘導され
る免疫グロブリンを生産するであろう。この場合におい
て、所望の免疫グロブリンは、トランスジェニック動物
から誘導されるハイブリドーマをふるい分けることによ
って、たとえば示差的染色体喪失または抗体遺伝子発現
の対立遺伝子排除の現象を活用することによって得るこ
とができる。
【００１４】さらに他の局面において、この発明は、特
にヒト以外の哺乳動物のトランスジェニック動物を生産
し、その動物は、その生殖系列に外来起源の免疫グロブ
リンの少なくとも一部をコードするか、または免疫グロ
ブリンのレパートリーをコードするために再配列できる
遺伝物質を挿入されたものである。
にヒト以外の哺乳動物のトランスジェニック動物を生産
し、その動物は、その生殖系列に外来起源の免疫グロブ
リンの少なくとも一部をコードするか、または免疫グロ
ブリンのレパートリーをコードするために再配列できる
遺伝物質を挿入されたものである。
【００１５】この発明はまた、その範囲において、この
発明に従うトランスジェニック動物から生産されたまた
はこの発明の方法によって生産された免疫グロブリンも
含む。
発明に従うトランスジェニック動物から生産されたまた
はこの発明の方法によって生産された免疫グロブリンも
含む。
【００１６】１つの例において、生殖系列配置免疫グロ
ブリンＶＨ遺伝子、Ｄセグメントのいくつか、およびす
べてのＪＨおよびＣｍｕ遺伝子セグメントを含み、その
生殖系列に導入されたＤＮＡセグメントを持つトランス
ジェニックマウスの系統が確立された。ＶＨ遺伝子の１
つ、すべてのＪＨセグメントおよびＩｇＭ抗体の分泌さ
れるＨ鎖定常領域をコードするエキソンは、ヒト起源で
あり、残りの物質はマウス起源であった。遺伝子セグメ
ントは、トランスジェニックマウスのリンパ組織におい
て生産的ＶＨ−Ｄ−ＪＨ結合を受け、血清において結果
として生じるヒト／マウスキメラのＩｇＭ抗体の合成を
伴う。
ブリンＶＨ遺伝子、Ｄセグメントのいくつか、およびす
べてのＪＨおよびＣｍｕ遺伝子セグメントを含み、その
生殖系列に導入されたＤＮＡセグメントを持つトランス
ジェニックマウスの系統が確立された。ＶＨ遺伝子の１
つ、すべてのＪＨセグメントおよびＩｇＭ抗体の分泌さ
れるＨ鎖定常領域をコードするエキソンは、ヒト起源で
あり、残りの物質はマウス起源であった。遺伝子セグメ
ントは、トランスジェニックマウスのリンパ組織におい
て生産的ＶＨ−Ｄ−ＪＨ結合を受け、血清において結果
として生じるヒト／マウスキメラのＩｇＭ抗体の合成を
伴う。
【００１７】免疫感作に続いて、ＮＳＯ骨髄腫とトラン
スジェニックマウスからの脾臓細胞との間での融合によ
りハイブリドーマが確立された。ハイブリッドの多くは
ヒトキメラのＩｇＭモノクローナル抗体を分泌する。し
たがって、トランスジェニックマウスのこれらの系統
は、キメラのヒト抗血清またはモノクローナル抗体の生
産のために使用できる。
スジェニックマウスからの脾臓細胞との間での融合によ
りハイブリドーマが確立された。ハイブリッドの多くは
ヒトキメラのＩｇＭモノクローナル抗体を分泌する。し
たがって、トランスジェニックマウスのこれらの系統
は、キメラのヒト抗血清またはモノクローナル抗体の生
産のために使用できる。
【００１８】さらに、マウスは、ヒト抗原による免疫感
作に続いて、導入された抗原に対してキメラの抗体を生
産する応答をし、したがってこのアプローチはヒトのお
よび異種の抗原に対して向けられる通常のヒトのまたは
キメラのヒト抗体のレパートリーを生産するためにも有
益であることが判明するはずであり、なぜならトランス
ジェニックマウスはヒト抗原の決定基に対して寛容でな
いであろうからである。
作に続いて、導入された抗原に対してキメラの抗体を生
産する応答をし、したがってこのアプローチはヒトのお
よび異種の抗原に対して向けられる通常のヒトのまたは
キメラのヒト抗体のレパートリーを生産するためにも有
益であることが判明するはずであり、なぜならトランス
ジェニックマウスはヒト抗原の決定基に対して寛容でな
いであろうからである。
【００１９】別の例においては、ヒトＶＨ、Ｄ、ＪＨお
よびＣｍｕ配列を独占的に持つトランスジェニックマウ
スが、受精マウス卵にヒトＶＨ遺伝子、Ｄセグメント、
ＪセグメントおよびＣｍｕ定常領域を含むコスミドを注
入することによって生産された。得られたマウスは、マ
ウスＩｇＭが約２００ｕｇ／ｍｌで存在する状態で、そ
の血清においてヒトｍｕ鎖を含む抗体を１０〜１００ｕ
ｇ／ｍｌの間で生産した。
よびＣｍｕ配列を独占的に持つトランスジェニックマウ
スが、受精マウス卵にヒトＶＨ遺伝子、Ｄセグメント、
ＪセグメントおよびＣｍｕ定常領域を含むコスミドを注
入することによって生産された。得られたマウスは、マ
ウスＩｇＭが約２００ｕｇ／ｍｌで存在する状態で、そ
の血清においてヒトｍｕ鎖を含む抗体を１０〜１００ｕ
ｇ／ｍｌの間で生産した。
【００２０】
【実施例】この発明はさらに添付の図面に関連する以下
の例において例示として説明される。
の例において例示として説明される。
【００２１】例１ トランスジーン
図１において示される構造を有するプラスミドＤＮＡが
マウス卵に注入された。この図において、ヒト配列は塗
りつぶされた棒によって表わされ、マウス配列は塗りつ
ぶされていない棒によって表わされ、ベクタは交差する
斜線が引かれた棒によって表わされ、かつＤ要素は斜線
が引かれた棒によって表わされる。制限エンドヌクレア
ーゼ開裂部位は以下のように、ＢｇｌＩＩがＢｇに、Ｐ
ｖｕｌがＰに、ＥｃｏＲＩがＲに、ＫｐｎｌがＫに、Ｂ
ａｍＨＩがＢに、ＸｂａＩがＸに、ＨｉｎｄＩＩＩがＨ
に略されている。
マウス卵に注入された。この図において、ヒト配列は塗
りつぶされた棒によって表わされ、マウス配列は塗りつ
ぶされていない棒によって表わされ、ベクタは交差する
斜線が引かれた棒によって表わされ、かつＤ要素は斜線
が引かれた棒によって表わされる。制限エンドヌクレア
ーゼ開裂部位は以下のように、ＢｇｌＩＩがＢｇに、Ｐ
ｖｕｌがＰに、ＥｃｏＲＩがＲに、ＫｐｎｌがＫに、Ｂ
ａｍＨＩがＢに、ＸｂａＩがＸに、ＨｉｎｄＩＩＩがＨ
に略されている。
【００２２】成分たるＤＮＡセグメントの起源は以下の
とおりである。ベクタ 充填されたＮａｒＩ部位にクローン化されたＢ
ｇｌＩＩリンカを含むｐＵＣ１２誘導体のＥｃｏＲＩ部
位とＢｇｌＩＩ部位との間に全「ミニＩｇＨ遺伝子座」
がクローン化された。
とおりである。ベクタ 充填されたＮａｒＩ部位にクローン化されたＢ
ｇｌＩＩリンカを含むｐＵＣ１２誘導体のＥｃｏＲＩ部
位とＢｇｌＩＩ部位との間に全「ミニＩｇＨ遺伝子座」
がクローン化された。
【００２３】ＶＨ遺伝子 ミニ遺伝子座においては２つ
のＶＨ遺伝子がある。ＶＨ２６は、ヒト起源のものであ
りかつファージラムダＶＨ２６からＢｇｌＩＩ−Ｅｃｏ
ＲＩ０．８５Ｋｂ断片として得られた（１９８０年、マ
ティセンズ・アンド・ラビッツ(Matthyssens & Rabbitt
s)ＰＮＡＳ、７７巻、６５６１頁ないし６５６５頁）。
ＶＨ−１８６．２は、Ｃ５７ＢＬ／６マウスからの生殖
系列ＶＨ遺伝子であり、かつ２．５ＫｂのＳａｃＩ−Ｋ
ｐｎＩ断片として得られた（ボースウェル（Bothwell)
、パスキンド(Paskind) 、リース(Reth)、イマニシ−
カリ（Imanishi-Kari)、ラジェウスキ(Rajewsky)および
バルチモア(Baltimore) １９８１年、セル(Cell)、２４
巻、６２５頁ないし６３７頁）。
のＶＨ遺伝子がある。ＶＨ２６は、ヒト起源のものであ
りかつファージラムダＶＨ２６からＢｇｌＩＩ−Ｅｃｏ
ＲＩ０．８５Ｋｂ断片として得られた（１９８０年、マ
ティセンズ・アンド・ラビッツ(Matthyssens & Rabbitt
s)ＰＮＡＳ、７７巻、６５６１頁ないし６５６５頁）。
ＶＨ−１８６．２は、Ｃ５７ＢＬ／６マウスからの生殖
系列ＶＨ遺伝子であり、かつ２．５ＫｂのＳａｃＩ−Ｋ
ｐｎＩ断片として得られた（ボースウェル（Bothwell)
、パスキンド(Paskind) 、リース(Reth)、イマニシ−
カリ（Imanishi-Kari)、ラジェウスキ(Rajewsky)および
バルチモア(Baltimore) １９８１年、セル(Cell)、２４
巻、６２５頁ないし６３７頁）。
【００２４】Ｄセグメント ＢＡＬＢ／ｃマウスＤ−Ｑ
５２要素は、２２１ ｎｔ ＸｈｏＩ−ＳａｃＩ断片と
して得られた。Ｍ１３ｔｇ１３１のＳａｃＩ部位とＳａ
ｌＩ部位との間でのクローン化に続き、オリゴヌクレオ
チド ５′−ＧＣＧＴＣＡＣＣＧＴＧＧＴＡＧＣＴＧＣＴＡＣ
ＣＧＴＡＧＴＡＡＴＡＡＡＣＡＣＴＧＴＧＧＴＣＣ、ま
たは５′−ＧＣＧＴＣＡＣＣＧＴＧＧＴＣＧＴＡＡＣＣ
ＡＴＡＧＴＡＧＡＣＡＣＴＧＴＧＧＴＧＣ のどちらかでの位置指定突然変異誘発が、マウスＳＰ２
およびＦＬ１６系統群のものにそれぞれ関連するＤ要素
をもつＭ１３ｔｇ１３１クローンをつくるために使用さ
れた。これらのＤ系統群はマウスおよびヒトの両方にお
いて見出される。別のＤ要素−ヒトＤ−Ｑ５２−はヒト
ＪＨクラスタ（以下を参照）内において含まれた。
５２要素は、２２１ ｎｔ ＸｈｏＩ−ＳａｃＩ断片と
して得られた。Ｍ１３ｔｇ１３１のＳａｃＩ部位とＳａ
ｌＩ部位との間でのクローン化に続き、オリゴヌクレオ
チド ５′−ＧＣＧＴＣＡＣＣＧＴＧＧＴＡＧＣＴＧＣＴＡＣ
ＣＧＴＡＧＴＡＡＴＡＡＡＣＡＣＴＧＴＧＧＴＣＣ、ま
たは５′−ＧＣＧＴＣＡＣＣＧＴＧＧＴＣＧＴＡＡＣＣ
ＡＴＡＧＴＡＧＡＣＡＣＴＧＴＧＧＴＧＣ のどちらかでの位置指定突然変異誘発が、マウスＳＰ２
およびＦＬ１６系統群のものにそれぞれ関連するＤ要素
をもつＭ１３ｔｇ１３１クローンをつくるために使用さ
れた。これらのＤ系統群はマウスおよびヒトの両方にお
いて見出される。別のＤ要素−ヒトＤ−Ｑ５２−はヒト
ＪＨクラスタ（以下を参照）内において含まれた。
【００２５】ＪＨクラスタ ６つの機能的なヒトＪＨセ
グメント、３つの擬似ＪＨおよびヒトＤ−Ｑ５２要素を
含む、ヒトＤＮＡからの３．５Ｋｂ ＢｇｌＩＩ断片が
使用された（ラベッチ(Ravetch) 他、１９８１年、セル
(Cell)、２７巻、５８３頁ないし５９１頁）ＩｇＨエンハンサ ヒトＩｇＨエンハンサの部分は、Ｊ
Ｈクラスタを含むＢｇｌＩＩ断片内に含まれる。マウス
エンハンサの完全な複製物は１Ｋｂ ＸｂａＩ断片内に
含まれる。
グメント、３つの擬似ＪＨおよびヒトＤ−Ｑ５２要素を
含む、ヒトＤＮＡからの３．５Ｋｂ ＢｇｌＩＩ断片が
使用された（ラベッチ(Ravetch) 他、１９８１年、セル
(Cell)、２７巻、５８３頁ないし５９１頁）ＩｇＨエンハンサ ヒトＩｇＨエンハンサの部分は、Ｊ
Ｈクラスタを含むＢｇｌＩＩ断片内に含まれる。マウス
エンハンサの完全な複製物は１Ｋｂ ＸｂａＩ断片内に
含まれる。
【００２６】Ｓ（スイッチ）領域およびＣｍｕ領域 ヒ
トＤＮＡの７．５Ｋｂ Ｘｂａｌ断片がｍｕＳ（スイッ
チ）領域およびｍｕＨ鎖定常領域のエキソン１〜４を含
む。ｍｕ膜エキソンおよびＣｍｕ４エキソンとＣｍｕＭ
ｌ膜エキソンとの間のイントロンの塊が、マウスｍｕＣ
Ｈ遺伝子の２．５Ｋｂ ＨｉｎｄＩＩＩ−ＳｐｈＩ断片
によって与えられ、そこにおいてＳｐｈＩ部位はリンカ
の使用によってＢｇｌＩＩ部位に変換された。
トＤＮＡの７．５Ｋｂ Ｘｂａｌ断片がｍｕＳ（スイッ
チ）領域およびｍｕＨ鎖定常領域のエキソン１〜４を含
む。ｍｕ膜エキソンおよびＣｍｕ４エキソンとＣｍｕＭ
ｌ膜エキソンとの間のイントロンの塊が、マウスｍｕＣ
Ｈ遺伝子の２．５Ｋｂ ＨｉｎｄＩＩＩ−ＳｐｈＩ断片
によって与えられ、そこにおいてＳｐｈＩ部位はリンカ
の使用によってＢｇｌＩＩ部位に変換された。
【００２７】トランスジェニックマウス
プラスミドＤＮＡはＢｇｌＩＩで線状にされ、アガロー
スゲルにおける電気泳動の後精製されかつ既に説明され
ているようにＣ５７ＢＬ／６Ｊ×ＣＢＡ／Ｃａマウスの
受精卵の雄性前核の中に注入された（レイク(Reik)他、
１９８７年、ヨーロピアン・ジャーナル・オブ・イムノ
ロジー(Eur.J.Immunol.)１７巻、４６５頁ないし４６９
頁）。尾部ＤＮＡのサザンブロット分析が、生まれた３
２匹のマウスのうち１２匹がミニ遺伝子座を持っていた
ことを明らかにした。最終的な研究は、それらすべてが
ミニ遺伝子座の少数の複製物（２ないし５）を持つ３匹
の基礎となるマウス−ＨＩｇ１７、１９および２９の子
孫において行なわれた。
スゲルにおける電気泳動の後精製されかつ既に説明され
ているようにＣ５７ＢＬ／６Ｊ×ＣＢＡ／Ｃａマウスの
受精卵の雄性前核の中に注入された（レイク(Reik)他、
１９８７年、ヨーロピアン・ジャーナル・オブ・イムノ
ロジー(Eur.J.Immunol.)１７巻、４６５頁ないし４６９
頁）。尾部ＤＮＡのサザンブロット分析が、生まれた３
２匹のマウスのうち１２匹がミニ遺伝子座を持っていた
ことを明らかにした。最終的な研究は、それらすべてが
ミニ遺伝子座の少数の複製物（２ないし５）を持つ３匹
の基礎となるマウス−ＨＩｇ１７、１９および２９の子
孫において行なわれた。
【００２８】血清のアッセイ
基礎となるマウスの血清は、ヒトＩｇＭの抗原決定基特
性を含む抗体の存在についてＥＬＩＳＡにより検査され
た。免疫感作されていないトランスジェニックマウス
は、それらの血清において１０〜１００ｕｇ／ｍｌの間
でキメラのヒトＩｇＭを含むことが判明した。末梢血に
おけるリンパ球の蛍光抗体分析もまた、ビオチニル化さ
れた種特異的な抗ヒトＩｇＭ抗体およびフルオレセイン
結合されたストレプトアビジンによる細胞染色の存在を
明らかにした。
性を含む抗体の存在についてＥＬＩＳＡにより検査され
た。免疫感作されていないトランスジェニックマウス
は、それらの血清において１０〜１００ｕｇ／ｍｌの間
でキメラのヒトＩｇＭを含むことが判明した。末梢血に
おけるリンパ球の蛍光抗体分析もまた、ビオチニル化さ
れた種特異的な抗ヒトＩｇＭ抗体およびフルオレセイン
結合されたストレプトアビジンによる細胞染色の存在を
明らかにした。
【００２９】トランスジェニックマウスからのハイブリ
ドーマ トランスジェニックマウスは、ヒト赤血球細胞またはヒ
ツジ赤血球細胞のどちらかで腹膜内で免疫処置された。
脾臓が免疫感作の後様々な時期に取り除かれ、ＨＡＴ培
地において選択されたハイブリッドおよびＮＳＯ骨髄腫
を用いて融合が行なわれた。これらのハイブリッドの多
くはＥＬＩＳＡアッセイによって明らかにされるとおり
キメラのヒトＩｇＭを作った。
ドーマ トランスジェニックマウスは、ヒト赤血球細胞またはヒ
ツジ赤血球細胞のどちらかで腹膜内で免疫処置された。
脾臓が免疫感作の後様々な時期に取り除かれ、ＨＡＴ培
地において選択されたハイブリッドおよびＮＳＯ骨髄腫
を用いて融合が行なわれた。これらのハイブリッドの多
くはＥＬＩＳＡアッセイによって明らかにされるとおり
キメラのヒトＩｇＭを作った。
【００３０】ミニ遺伝子座のＤＮＡ再配列
ハイブリドーマからと同様にトランスジェニックマウス
からの組織からのＤＮＡのサザンブロット分析は、トラ
ンスジェニックマウスのリンパ組織におけるミニＩｇ遺
伝子座内において高頻度のＤＮＡ再配列があることを明
らかにした。
からの組織からのＤＮＡのサザンブロット分析は、トラ
ンスジェニックマウスのリンパ組織におけるミニＩｇ遺
伝子座内において高頻度のＤＮＡ再配列があることを明
らかにした。
【００３１】トランスジェニックマウスから確立された
組織またはハイブリドーマからのＤＮＡは、ＥｃｏＲＩ
で消化され、かつミニ遺伝子座におけるヒトＪ６要素と
マウスＩｇＨエンハンサとの間の領域に対してハイブリ
ッド形成するヒトＩｇＨエンハンサプローブ（ＢａｌＩ
−ＢｇｌＩＩ断片）とハイブリッド形成された。ＤＮＡ
のサザンブロット分析の結果は図２に示される。標識断
片のＫｂによるサイズが図に与えられている。
組織またはハイブリドーマからのＤＮＡは、ＥｃｏＲＩ
で消化され、かつミニ遺伝子座におけるヒトＪ６要素と
マウスＩｇＨエンハンサとの間の領域に対してハイブリ
ッド形成するヒトＩｇＨエンハンサプローブ（ＢａｌＩ
−ＢｇｌＩＩ断片）とハイブリッド形成された。ＤＮＡ
のサザンブロット分析の結果は図２に示される。標識断
片のＫｂによるサイズが図に与えられている。
【００３２】ミニ遺伝子座の転写
トランスジェニックマウスからのハイブリドーマからの
またはＮＳＯ融合のパートナーからの細胞質ＲＮＡ（５
ｕｇ）が、ヒトＣｍｕ、ヒトＶＨ２６またはマウスＶＨ
１８６プローブでプローブされた。細胞質ＲＮＡのノー
ザンブロット分析の結果は図３に示され、それは、ハイ
ブリドーマがＶＨ２６、ＶＨ１８６Ｖ遺伝子のどちらか
または両方に対すると同様にヒトｍｕに対するプローブ
とハイブリッド形成するｍＲＮＡを含んでいたことを明
らかにしている。こうしてヒトＶＨ２６およびマウスＶ
Ｈ１８６の両方は再配列できかつ従ってキメラのヒトＩ
ｇＭ抗体を分泌する細胞系を造ることができる。
またはＮＳＯ融合のパートナーからの細胞質ＲＮＡ（５
ｕｇ）が、ヒトＣｍｕ、ヒトＶＨ２６またはマウスＶＨ
１８６プローブでプローブされた。細胞質ＲＮＡのノー
ザンブロット分析の結果は図３に示され、それは、ハイ
ブリドーマがＶＨ２６、ＶＨ１８６Ｖ遺伝子のどちらか
または両方に対すると同様にヒトｍｕに対するプローブ
とハイブリッド形成するｍＲＮＡを含んでいたことを明
らかにしている。こうしてヒトＶＨ２６およびマウスＶ
Ｈ１８６の両方は再配列できかつ従ってキメラのヒトＩ
ｇＭ抗体を分泌する細胞系を造ることができる。
【００３３】トランスジェニックマウスからのハイブリ
ドーマによる抗体分泌 クローン化されたハイブリドーマ細胞系によるタンパク
質生産は、Ｌ−［3 5Ｓ］メチオニンによる生合成標識
の使用およびその後の抗ヒトｍｕ抗血清での精製により
分析された。特に、細胞は、Ｌ−［3 5 Ｓ］メチオニン
および免疫沈降により培養上澄みから精製されたＩｇＭ
抗体ならびに抗ヒトｍｕ抗血清を含む培地にてひと晩イ
ンキュベートされた。トランスジェニックハイブリドー
マ３５．５および２４ａの上澄みからの精製は、図４に
おいて「＋」によって示されるように非放射性の、精製
されたマウスモノクローナルＩｇＭ抗体（Ｂ１−８）の
大過剰（５０ｕｇ）の存在下で達成された。マウスＩｇ
Ｍ分泌細胞系を使用して見られるように、抗ヒトｍｕ抗
血清はマウスｍｕと交差反応するが、この交差反応は非
放射性のマウスＢ１−８ＩｇＭ抗体によって競争され得
る−図４の左の４つのレーンを参照。
ドーマによる抗体分泌 クローン化されたハイブリドーマ細胞系によるタンパク
質生産は、Ｌ−［3 5Ｓ］メチオニンによる生合成標識
の使用およびその後の抗ヒトｍｕ抗血清での精製により
分析された。特に、細胞は、Ｌ−［3 5 Ｓ］メチオニン
および免疫沈降により培養上澄みから精製されたＩｇＭ
抗体ならびに抗ヒトｍｕ抗血清を含む培地にてひと晩イ
ンキュベートされた。トランスジェニックハイブリドー
マ３５．５および２４ａの上澄みからの精製は、図４に
おいて「＋」によって示されるように非放射性の、精製
されたマウスモノクローナルＩｇＭ抗体（Ｂ１−８）の
大過剰（５０ｕｇ）の存在下で達成された。マウスＩｇ
Ｍ分泌細胞系を使用して見られるように、抗ヒトｍｕ抗
血清はマウスｍｕと交差反応するが、この交差反応は非
放射性のマウスＢ１−８ＩｇＭ抗体によって競争され得
る−図４の左の４つのレーンを参照。
【００３４】これは、異なったヒトｍｕ鎖を有する抗体
を分泌するこれらのトランスジェニックマウスからのハ
イブリドーマを確立することが可能であることを示す。
を分泌するこれらのトランスジェニックマウスからのハ
イブリドーマを確立することが可能であることを示す。
【００３５】例２
それらの体液および外部分泌物において特異的な抗体を
生産するトランスジェニック動物をつくることができ
る。例示として、この例は、抗原特異的キメラのヒトＩ
ｇＡ２抗体のＨ鎖およびＬ鎖をコードする遺伝子をそれ
らの生殖系列に組込まれて保有するトランスジェニック
マウスに関するものである。
生産するトランスジェニック動物をつくることができ
る。例示として、この例は、抗原特異的キメラのヒトＩ
ｇＡ２抗体のＨ鎖およびＬ鎖をコードする遺伝子をそれ
らの生殖系列に組込まれて保有するトランスジェニック
マウスに関するものである。
【００３６】図５に示されているＤＮＡの生殖系列組込
み物を保有する９つのトランスジェニックマウス系統が
確立された。図５において、太く塗られた線はマウスＩ
ｇＤＮＡを示し、斜線が引かれた部分はヒトＤＮＡを、
空白の部分はマウスＩｇＨおよびＳＶ４０エンハンサ
を、かつ細く塗られた線はｐＳＶ２ｇｐｔベクタを示
す。制限部位の略語は図１と同様である。プラスミド
は、既に説明されているｐＳＶ−ＶＮＰＨα２の誘導体
であり（ブルゲマン(Bruggemann)他、J.Exp.Med 、１９
８７年、１６６巻、１３５１頁ないし１３６１頁）かつ
マウスＨＯＰＣ２０２０形質細胞腫の再配列されたラム
ダ１遺伝子を含む７．４ｋｂ ＥｃｏＲＩ断片を含んで
いる（バーナード(Bernard) 他、１９７８年、セル(Cel
l)１５巻、１１３３頁ないし１１４０頁）。プラスミド
ＤＮＡは、ベクタにおけるＰｖｕＩ部位において線状に
され、既に説明されているようにトランスジェニックマ
ウスが誘導された（レイク(Reik)他、Eur. F. Immunol
、１９８７年、１７巻、４６５頁ないし４６９頁）。
み物を保有する９つのトランスジェニックマウス系統が
確立された。図５において、太く塗られた線はマウスＩ
ｇＤＮＡを示し、斜線が引かれた部分はヒトＤＮＡを、
空白の部分はマウスＩｇＨおよびＳＶ４０エンハンサ
を、かつ細く塗られた線はｐＳＶ２ｇｐｔベクタを示
す。制限部位の略語は図１と同様である。プラスミド
は、既に説明されているｐＳＶ−ＶＮＰＨα２の誘導体
であり（ブルゲマン(Bruggemann)他、J.Exp.Med 、１９
８７年、１６６巻、１３５１頁ないし１３６１頁）かつ
マウスＨＯＰＣ２０２０形質細胞腫の再配列されたラム
ダ１遺伝子を含む７．４ｋｂ ＥｃｏＲＩ断片を含んで
いる（バーナード(Bernard) 他、１９７８年、セル(Cel
l)１５巻、１１３３頁ないし１１４０頁）。プラスミド
ＤＮＡは、ベクタにおけるＰｖｕＩ部位において線状に
され、既に説明されているようにトランスジェニックマ
ウスが誘導された（レイク(Reik)他、Eur. F. Immunol
、１９８７年、１７巻、４６５頁ないし４６９頁）。
【００３７】トランスジェニックＩｇＡ２ラムダ抗体
は、ハプテン４−ヒドロキシ−３−ニトロフェンアセチ
ル（ＮＰ）に対して特異性を有する。トランスジェニッ
ク抗体の発現は、プラスチックプレートに結合されたＮ
Ｐウシ血清アルブミンを使用しかつビオチニル化された
抗ヒトアルファ抗血清で展開するＥＬＩＳＡアッセイに
よって測定された。Ｉｇ全体は、抗マウスＩｇ被覆され
たプラスチックを使用しかつビオチニル化された抗マウ
スカッパ抗血清で展開して測定された。キメラの抗ＮＰ
ＩｇＡ２の濃度は、７匹のトランスジェニックマウスお
よび１匹の対照マウスからの初乳、血清および乳汁にお
いて測定され、その結果は表１に示される。初乳は出産
から２４時間以内にホルモン注射に続いて母親からとら
れ、かつ乳汁は同腹子が生後１３〜１５日目であったと
き母親からとられ、血清は乳汁と同じときに得られた。
は、ハプテン４−ヒドロキシ−３−ニトロフェンアセチ
ル（ＮＰ）に対して特異性を有する。トランスジェニッ
ク抗体の発現は、プラスチックプレートに結合されたＮ
Ｐウシ血清アルブミンを使用しかつビオチニル化された
抗ヒトアルファ抗血清で展開するＥＬＩＳＡアッセイに
よって測定された。Ｉｇ全体は、抗マウスＩｇ被覆され
たプラスチックを使用しかつビオチニル化された抗マウ
スカッパ抗血清で展開して測定された。キメラの抗ＮＰ
ＩｇＡ２の濃度は、７匹のトランスジェニックマウスお
よび１匹の対照マウスからの初乳、血清および乳汁にお
いて測定され、その結果は表１に示される。初乳は出産
から２４時間以内にホルモン注射に続いて母親からとら
れ、かつ乳汁は同腹子が生後１３〜１５日目であったと
き母親からとられ、血清は乳汁と同じときに得られた。
【００３８】これらのデータから、トランスジェニック
動物は、特定の抗体の生産のために使用することがで
き、そして特定の有用な抗体が混ざった乳汁を生ずる動
物の繁殖が可能になるとともに、乳汁、初乳、血清、唾
液等からの大規模な生産が可能になるということが明ら
かである。トランスジェニック抗体の濃度は乳汁におい
てよりも初乳においての方がより高いということもまた
明らかである。さらに、トランスジーンの存在は、大量
の内因性の抗体を作るという動物の能力に影響を及ぼさ
ない。動物は著しく免疫不全または不健康な状態の徴候
を示さない。
動物は、特定の抗体の生産のために使用することがで
き、そして特定の有用な抗体が混ざった乳汁を生ずる動
物の繁殖が可能になるとともに、乳汁、初乳、血清、唾
液等からの大規模な生産が可能になるということが明ら
かである。トランスジェニック抗体の濃度は乳汁におい
てよりも初乳においての方がより高いということもまた
明らかである。さらに、トランスジーンの存在は、大量
の内因性の抗体を作るという動物の能力に影響を及ぼさ
ない。動物は著しく免疫不全または不健康な状態の徴候
を示さない。
【００３９】例３
この例において、トランスジェニックマウスからヒトｍ
ｕ鎖を使用して抗原特異的ハイブリドーマが生産され
た。例１に記載されるトランスジェニックマウスが、抗
原結合部位に対するＨ鎖の寄与がトランスジェニックヒ
トＨ鎖ミニ遺伝子座によってもたらされる抗原特異的抗
体を生産するために使用できることを示すために、該ト
ランスジェニックマウスは１０7 のヒツジ赤血球（ＳＲ
Ｃ）で免疫処置された。脾臓細胞が６日後ＮＳＯ形質細
胞腫と融合された（ケーラー(Kohler)およびミルスタイ
ン(Milstein)、ネイチャ(Nature)、２５６号、４９５頁
ないし４９７頁、１９７５年）。細胞は、予期される播
種頻度がウェルあたり１ハイブリドーマであるように９
６−ウェルコスタープレートで培養された。ヒトｍｕ陽
性ハイブリッドが、ビオチニル化された抗ヒトＩｇＭを
使用しＥＬＩＳＡにおいて検出された。抗原特異的ハイ
ブリッドは、ヒツジ赤血球を使用し赤血球凝集において
同定された。ＥＬＩＳＡによって決定されたように、ヒ
ツジ赤血球に特異的な抗体を含み、かつヒトｍｕを含
み、しかしマウスｍｕまたはマウスガンマＨ鎖のどちら
も含まないウェルが選ばれた。
ｕ鎖を使用して抗原特異的ハイブリドーマが生産され
た。例１に記載されるトランスジェニックマウスが、抗
原結合部位に対するＨ鎖の寄与がトランスジェニックヒ
トＨ鎖ミニ遺伝子座によってもたらされる抗原特異的抗
体を生産するために使用できることを示すために、該ト
ランスジェニックマウスは１０7 のヒツジ赤血球（ＳＲ
Ｃ）で免疫処置された。脾臓細胞が６日後ＮＳＯ形質細
胞腫と融合された（ケーラー(Kohler)およびミルスタイ
ン(Milstein)、ネイチャ(Nature)、２５６号、４９５頁
ないし４９７頁、１９７５年）。細胞は、予期される播
種頻度がウェルあたり１ハイブリドーマであるように９
６−ウェルコスタープレートで培養された。ヒトｍｕ陽
性ハイブリッドが、ビオチニル化された抗ヒトＩｇＭを
使用しＥＬＩＳＡにおいて検出された。抗原特異的ハイ
ブリッドは、ヒツジ赤血球を使用し赤血球凝集において
同定された。ＥＬＩＳＡによって決定されたように、ヒ
ツジ赤血球に特異的な抗体を含み、かつヒトｍｕを含
み、しかしマウスｍｕまたはマウスガンマＨ鎖のどちら
も含まないウェルが選ばれた。
【００４０】選択されたハイブリドーマによって分泌さ
れる抗体が本当にヒトｍｕ／マウスＬ鎖抗ＳＲＣ免疫グ
ロブリンであることを示すために、蛍光活性化セルソー
タ（ＦＡＣＳ）における分析が使用された。ＦＡＣＳ分
析のために、１０7 のヒツジ赤血球が３０分間２０ｕｌ
培養上清とともにインキュベートされ、リン酸塩緩衝生
理食塩水で一度洗われ、さらにビオチニル化された抗ヒ
トｍｕＨ鎖抗血清、ビオチニル化された抗マウスｍｕ抗
血清またはビオチニル化された抗マウスカッパＬ鎖抗血
清のどれかとともにインキュベートされた。３０分後細
胞は、前のように洗われ、かつＦＩＴＣ結合されたスト
レプトアビジンとともにインキュベートされた。細胞は
３０分後に洗われ、ゆるやかな破壊の後、分析のための
用意ができた。
れる抗体が本当にヒトｍｕ／マウスＬ鎖抗ＳＲＣ免疫グ
ロブリンであることを示すために、蛍光活性化セルソー
タ（ＦＡＣＳ）における分析が使用された。ＦＡＣＳ分
析のために、１０7 のヒツジ赤血球が３０分間２０ｕｌ
培養上清とともにインキュベートされ、リン酸塩緩衝生
理食塩水で一度洗われ、さらにビオチニル化された抗ヒ
トｍｕＨ鎖抗血清、ビオチニル化された抗マウスｍｕ抗
血清またはビオチニル化された抗マウスカッパＬ鎖抗血
清のどれかとともにインキュベートされた。３０分後細
胞は、前のように洗われ、かつＦＩＴＣ結合されたスト
レプトアビジンとともにインキュベートされた。細胞は
３０分後に洗われ、ゆるやかな破壊の後、分析のための
用意ができた。
【００４１】ヒツジ赤血球抗原に対して向けられるＩｇ
Ｍを生産する３つの異なったハイブリッドに対する結果
が図６、図７および図８のＦＡＣＳヒストグラムにそれ
ぞれ示されている。
Ｍを生産する３つの異なったハイブリッドに対する結果
が図６、図７および図８のＦＡＣＳヒストグラムにそれ
ぞれ示されている。
【００４２】これらの図における文字Ａ、Ｂ、Ｃおよび
Ｄは異なった染色を表示する。図６Ａ、図７Ａ、図８Ａ
は、ヒツジ赤血球だけ、抗体とともにインキュベートさ
れたヒツジ赤血球、またはフルオレセイン化された（Ｆ
ＩＴＣ）第２の抗体（抗ヒトｍｕ抗マウスｍｕ、抗マウ
スカッパのどれか）とともにインキュベートされたヒツ
ジ赤血球を使用した陰性のコントロールに対する結果で
ある。図６Ｂ、図７Ｂ、図８Ｂは、ハイブリッド培養上
清およびフルオレセイン化された（ＦＩＴＣ）抗ヒトｍ
ｕとともにインキュベートされたヒツジ赤血球を使用し
た結果である。図６Ｃ、図７Ｃ、図８Ｃは、トランスジ
ェニックハイブリッドからの培養上清およびフルオレセ
イン化された（ＦＩＴＣ）抗マウスｍｕとともにインキ
ュベートされたヒツジ赤血球を使用した結果である。図
６Ｄは、ハイブリッド培養上清およびフルオレセイン化
された（ＦＩＴＣ）抗マウスカッパとともにインキュベ
ートされたヒツジ赤血球を使用した結果である。
Ｄは異なった染色を表示する。図６Ａ、図７Ａ、図８Ａ
は、ヒツジ赤血球だけ、抗体とともにインキュベートさ
れたヒツジ赤血球、またはフルオレセイン化された（Ｆ
ＩＴＣ）第２の抗体（抗ヒトｍｕ抗マウスｍｕ、抗マウ
スカッパのどれか）とともにインキュベートされたヒツ
ジ赤血球を使用した陰性のコントロールに対する結果で
ある。図６Ｂ、図７Ｂ、図８Ｂは、ハイブリッド培養上
清およびフルオレセイン化された（ＦＩＴＣ）抗ヒトｍ
ｕとともにインキュベートされたヒツジ赤血球を使用し
た結果である。図６Ｃ、図７Ｃ、図８Ｃは、トランスジ
ェニックハイブリッドからの培養上清およびフルオレセ
イン化された（ＦＩＴＣ）抗マウスｍｕとともにインキ
ュベートされたヒツジ赤血球を使用した結果である。図
６Ｄは、ハイブリッド培養上清およびフルオレセイン化
された（ＦＩＴＣ）抗マウスカッパとともにインキュベ
ートされたヒツジ赤血球を使用した結果である。
【００４３】図６および図８において細胞の固定数の蛍
光強度が細胞数に対してプロットされる。図７において
は、細胞の固定数の蛍光強度が散点に対してプロットさ
れ、各点は細胞を表わす。
光強度が細胞数に対してプロットされる。図７において
は、細胞の固定数の蛍光強度が散点に対してプロットさ
れ、各点は細胞を表わす。
【００４４】プロファイルの右へのシフト（増加される
蛍光）は、ヒトｍｕＨ鎖およびマウスカッパＬ鎖を含む
抗体に対してのみ見ることができるが、マウスｍｕＨ鎖
またはマウスガンマＨ鎖を含む抗体に対しては見ること
ができない（図示せず）ポジティブ染色を示している。
蛍光）は、ヒトｍｕＨ鎖およびマウスカッパＬ鎖を含む
抗体に対してのみ見ることができるが、マウスｍｕＨ鎖
またはマウスガンマＨ鎖を含む抗体に対しては見ること
ができない（図示せず）ポジティブ染色を示している。
【００４５】
表１
ＩｇＡ２、ラムダ１−マウスの体液における抗体
ＩｇＡ２抗ＮＰ Ａｂ Ａｂを保持するカッパのトータル
マウス 血清 乳汁 初乳 乳汁 初乳
ＴＧ１ 10 0.6 2.1 960 600
ＴＧ２ 6.3 0.56 1.4 1000 420
ＴＧ３ 11.3 1.3 ND 735 ND
ＴＧ４ 7.3 0.8 1.4 780 660
ＴＧ５ 30 7.6 10.0 1250 ND
ＴＧ６ 34.6 5.0 10.0 500 600
ＴＧ７ 6.3 0.64 0.93 780 600
対照 0 0 0 1136 660
ＮＤ：測定されず
すべての濃度はｕｇ／ｍｌである
【図１】 プラスミドＤＮＡの構造を表わす図である。
【図２】 図１のＤＮＡが生殖系列に組込まれたトラン
スジェニックマウスから誘導されるハイブリドーマから
のおよび組織からのＤＮＡのサザンブロット分析を表わ
す図である。
スジェニックマウスから誘導されるハイブリドーマから
のおよび組織からのＤＮＡのサザンブロット分析を表わ
す図である。
【図３】 トランスジェニックマウスからのハイブリド
ーマからの細胞質ＲＮＡのノーザンブロット分析を表わ
す図である。
ーマからの細胞質ＲＮＡのノーザンブロット分析を表わ
す図である。
【図４】 トランスジェニックマウスから確立されたハ
イブリドーマの２つによって分泌された免疫グロブリン
の分析を表わす図である。
イブリドーマの２つによって分泌された免疫グロブリン
の分析を表わす図である。
【図５】 ＩｇＡラムダプラスミドＤＮＡの構造を表わ
す図である。
す図である。
【図６】 細胞数に対してプロットされた細胞の固定数
の蛍光強度を示す一連のＦＡＣＳヒストグラムを表わす
図である。
の蛍光強度を示す一連のＦＡＣＳヒストグラムを表わす
図である。
【図７】 散点に対してプロットされた細胞の固定数の
蛍光強度を示す一連のＦＡＣＳプロファイルであり、各
点は細胞を表わす図である。
蛍光強度を示す一連のＦＡＣＳプロファイルであり、各
点は細胞を表わす図である。
【図８】 図６と同様のさらに他の一連のＦＡＣＳヒス
トグラムを表わす図である。
トグラムを表わす図である。
フロントページの続き
(71)出願人 502391943
ブルッジマン，マリアンヌ
ＢＲＵＧＧＥＭＡＮ， ＭＡＲＩＡＮＮＥ
イギリス、シィ・ビィ・２ ６・エス・エ
イ ケンブリッジ、フォクストン、ステイ
ション・ロード、２、“ホムリア"
(72)発明者 スラーニ，アージム・エム
イギリス、シィ・ビィ・４ ３・エイ・エ
イチ ケンブリッジ、マグラー・アベニ
ュ、27
(72)発明者 ノイバーガー，マイケル・サミュエル
イギリス、シィ・ビィ・２ １・エヌ・エ
イ ケンブリッジ、ベイトマン・ストリー
ト、34
(72)発明者 ブルッジマン，マリアンヌ
イギリス、シィ・ビィ・２ ６・エス・エ
イ ケンブリッジ、フォクストン、ステイ
ション・ロード、２、“ホムリア"
Ｆターム(参考） 4B024 AA01 BA43 CA06 CA12 DA02
GA12 HA17
4B064 AG26 CA10 CA20 CC24 DA01
4H045 AA11 AA20 CA40 DA75 EA22
FA74
Claims (11)
- 【請求項１】 ヒト由来免疫グロブリンのＨ鎖領域をコ
ードする遺伝子セグメントを含み、ヒト由来の免疫グロ
ブリンの少なくとも一部をコードする外来ＤＮＡを、ヒ
ト以外の動物の生殖系列内に導入することにより、ヒト
以外のトランスジェニック動物を生産し、 それにより、前記外来起源のＤＮＡを、免疫グロブリ
ン、免疫グロブリンの断片、あるいはキメラの免疫グロ
ブリン分子をコードする多様な再配列した遺伝子を生産
するように、前記トランスジェニック動物のリンパ組織
内において再配列または変異させ、 それにより、前記トランスジェニック動物を特定の抗原
で攻撃することに続いて、前記再配列または変異された
ＤＮＡにコードされた前記特定の抗原に対する前記免疫
グロブリンを、前記動物の細胞内または体液内において
発現させるステップと、 前記動物の細胞または適当な体液から免疫グロブリンを
得るステップと、を備える、特定の抗原に対する免疫グ
ロブリンを生産する方法。 - 【請求項２】 前記免疫グロブリンを含むポリクローナ
ル抗体が前記動物から得られる、請求項１に記載の方
法。 - 【請求項３】 前記免疫グロブリンを含むモノクローナ
ル抗体が前記動物から得られる細胞を用いて生産され
る、請求項１に記載の方法。 - 【請求項４】 前記免疫グロブリンは前記動物の体液内
または分泌液内において生産される、請求項１に記載の
方法。 - 【請求項５】 前記免疫グロブリンは前記動物から得ら
れる細胞からインビトロで生産される、請求項１に記載
の方法。 - 【請求項６】 前記導入されたＤＮＡは免疫グロブリン
の種特異的な全領域を実質的にコードする、請求項１〜
５のいずれかに記載の方法。 - 【請求項７】 前記トランスジェニック動物はマウスで
ある、請求項１〜６のいずれかに記載の方法。 - 【請求項８】 前記導入されたＤＮＡは単数のプラスミ
ドまたはコスミド、複数のプラスミドまたはコスミド、
酵母人工染色体、あるいは脊椎動物の染色体またはＤＮ
Ａの断片を構成要素として含む、請求項１〜７のいずれ
かに記載の方法。 - 【請求項９】 前記ＤＮＡは受精卵または胚性幹細胞に
注射または他の方法により導入される、請求項１〜８の
いずれかに記載の方法。 - 【請求項１０】 前記動物は免疫グロブリンの定常領域
をコードする遺伝物質を最初は保有していない、請求項
１〜９のいずれかに記載の方法。 - 【請求項１１】 請求項１〜１０のいずれかに記載の方
法により得ることのできる、外来起源の免疫グロブリ
ン。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8823869.6 | 1988-10-12 | ||
| GB888823869A GB8823869D0 (en) | 1988-10-12 | 1988-10-12 | Production of antibodies |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51081289A Division JP3484442B2 (ja) | 1988-10-12 | 1989-10-12 | トランスジェニック動物からの抗体の生産 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003192699A true JP2003192699A (ja) | 2003-07-09 |
| JP2003192699A5 JP2003192699A5 (ja) | 2004-07-15 |
| JP3871997B2 JP3871997B2 (ja) | 2007-01-24 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51081289A Expired - Lifetime JP3484442B2 (ja) | 1988-10-12 | 1989-10-12 | トランスジェニック動物からの抗体の生産 |
| JP2002314611A Expired - Lifetime JP3871997B2 (ja) | 1988-10-12 | 2002-10-29 | トランスジェニック動物からの抗体の生産 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51081289A Expired - Lifetime JP3484442B2 (ja) | 1988-10-12 | 1989-10-12 | トランスジェニック動物からの抗体の生産 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5545807A (ja) |
| EP (1) | EP0438474B1 (ja) |
| JP (2) | JP3484442B2 (ja) |
| KR (1) | KR0164608B1 (ja) |
| AT (1) | ATE138104T1 (ja) |
| AU (1) | AU4417389A (ja) |
| DE (1) | DE68926508T2 (ja) |
| GB (1) | GB8823869D0 (ja) |
| WO (1) | WO1990004036A1 (ja) |
Families Citing this family (2455)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8906214D0 (en) * | 1989-03-17 | 1989-05-04 | Nat Res Dev | Introducing an exogenous gene into birds |
| WO1991000906A1 (en) * | 1989-07-12 | 1991-01-24 | Genetics Institute, Inc. | Chimeric and transgenic animals capable of producing human antibodies |
| US6673986B1 (en) * | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| DK0463151T3 (da) * | 1990-01-12 | 1996-07-01 | Cell Genesys Inc | Frembringelse af xenogene antistoffer |
| US6657103B1 (en) | 1990-01-12 | 2003-12-02 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6713610B1 (en) | 1990-01-12 | 2004-03-30 | Raju Kucherlapati | Human antibodies derived from immunized xenomice |
| US6150584A (en) * | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6075181A (en) * | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| DE4000939A1 (de) * | 1990-01-15 | 1991-07-18 | Brem Gottfried Prof Dr Dr | Verfahren zur antikoerpergewinnung |
| GB9003791D0 (en) * | 1990-02-20 | 1990-04-18 | Ludwig Inst Cancer Res | Transgenic animals,cell lines therefrom,and their use |
| US5661016A (en) * | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) * | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) * | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| DE69133476T2 (de) * | 1990-08-29 | 2006-01-05 | GenPharm International, Inc., Palo Alto | Transgene Mäuse fähig zur Produktion heterologer Antikörper |
| US5877397A (en) * | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5545806A (en) * | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US7041871B1 (en) | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US7084260B1 (en) | 1996-10-10 | 2006-08-01 | Genpharm International, Inc. | High affinity human antibodies and human antibodies against human antigens |
| US5814318A (en) * | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| WO1993012227A1 (en) * | 1991-12-17 | 1993-06-24 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5770429A (en) * | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
| US5874299A (en) * | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5866759A (en) * | 1991-02-20 | 1999-02-02 | Ludwig Institute For Cancer Research | Transgenic mice expressing TSSV40 large T antigen |
| GB9119338D0 (en) * | 1991-09-10 | 1991-10-23 | Inst Of Animal Physiology And | Control of gene expression |
| AU781922B2 (en) * | 1991-12-17 | 2005-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| DE4228162C1 (de) | 1992-08-25 | 1994-01-13 | Rajewsky Klaus Dr | Verfahren zum Ersetzen homologer Genabschnitte aus Säugern in der Keimbahn von nicht-menschlichen Säugern |
| AU6819494A (en) * | 1993-04-26 | 1994-11-21 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| RU2025487C1 (ru) * | 1993-10-18 | 1994-12-30 | Товарищество с ограниченной ответственностью "БиоПрогресс" | Способ направленной генетической трансформации молочной железы животного и устройство для введения генетического материала в молочный проток молочной железы животного |
| US5827690A (en) * | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| US6472585B1 (en) | 1994-04-25 | 2002-10-29 | Genentech, Inc. | Cardiotrophin-1 defective mouse |
| US7258983B2 (en) * | 1994-04-25 | 2007-08-21 | Genentech, Inc. | Cardiotrophin-1 compositions and methods for the treatment of tumor |
| US20020187131A1 (en) * | 1995-01-31 | 2002-12-12 | Daniel Hawiger | Enhanced antigen delivery and modulation of the immune response therefrom |
| US20040258688A1 (en) * | 1995-01-31 | 2004-12-23 | Daniel Hawiger | Enhanced antigen delivery and modulation of the immune response therefrom |
| DE69633238T2 (de) * | 1995-06-07 | 2005-09-15 | Wohlstadter, Jacob N. | Methode zur erhöhung der enzymdiversität |
| US7060808B1 (en) * | 1995-06-07 | 2006-06-13 | Imclone Systems Incorporated | Humanized anti-EGF receptor monoclonal antibody |
| ES2218598T3 (es) | 1995-09-14 | 2004-11-16 | The Regents Of The University Of California | Anticuerpo especifico del prpsc natural. |
| US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| DE122004000004I1 (de) * | 1996-02-09 | 2004-08-12 | Abott Biotechnology Ltd | Humane Antikörper welche an Humanen TNFalpha binden. |
| EP1378525A3 (en) | 1996-06-07 | 2004-01-14 | Neorx Corporation | Humanized antibodies that bind to the antigen bound by antibody NR-LU-13 and their use in pretargeting methods |
| JP4215172B2 (ja) * | 1996-12-03 | 2009-01-28 | アムジェン フレモント インク． | 複数のＶ▲下Ｈ▼およびＶ▲下κ▼領域を含むヒトＩｇ遺伝子座を有するトランスジェニック哺乳動物、ならびにそれから産生される抗体 |
| WO1998045331A2 (en) | 1997-04-07 | 1998-10-15 | Genentech, Inc. | Anti-vegf antibodies |
| SI1787999T1 (sl) | 1997-04-07 | 2010-12-31 | Genentech Inc | Anti-VEGF protitelesa |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| US20020192209A1 (en) * | 1997-09-17 | 2002-12-19 | Genentech, Inc. | Methods and compositions for inhibiting neoplastic cell growth |
| DK1887014T3 (da) | 1997-10-17 | 2010-08-02 | Genentech Inc | Humane Toll-homologer |
| US7192589B2 (en) | 1998-09-16 | 2007-03-20 | Genentech, Inc. | Treatment of inflammatory disorders with STIgMA immunoadhesins |
| PT1481990E (pt) | 1997-11-21 | 2007-09-17 | Genentech Inc | Antigénios relacionados com a-33 e suas utilizações farmacológicas |
| US6764830B1 (en) | 1998-01-23 | 2004-07-20 | The Regents Of The University Of California | Thermomyces lanuginosus kinesin motor protein and methods of screening for modulators of kinesin proteins |
| US20030224001A1 (en) * | 1998-03-19 | 2003-12-04 | Goldstein Neil I. | Antibody and antibody fragments for inhibiting the growth of tumors |
| US20020029391A1 (en) * | 1998-04-15 | 2002-03-07 | Claude Geoffrey Davis | Epitope-driven human antibody production and gene expression profiling |
| ZA200007412B (en) * | 1998-05-15 | 2002-03-12 | Imclone Systems Inc | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases. |
| ATE365800T1 (de) | 1998-05-15 | 2007-07-15 | Genentech Inc | Therapeutische verwendungen von il-17 homologe polypeptide |
| EP3112468A1 (en) | 1998-05-15 | 2017-01-04 | Genentech, Inc. | Il-17 homologous polypeptides and therapeutic uses thereof |
| JP2002517223A (ja) | 1998-06-12 | 2002-06-18 | ジェネンテック・インコーポレーテッド | モノクローナル抗体、交叉反応性抗体およびそれを生成する方法 |
| NZ508950A (en) | 1998-07-13 | 2003-10-31 | Univ Texas | Cancer treatment methods using antibodies to aminophospholipids |
| US6312689B1 (en) | 1998-07-23 | 2001-11-06 | Millennium Pharmaceuticals, Inc. | Anti-CCR2 antibodies and methods of use therefor |
| US20020172678A1 (en) | 2000-06-23 | 2002-11-21 | Napoleone Ferrara | EG-VEGF nucleic acids and polypeptides and methods of use |
| US6270747B1 (en) | 1998-08-18 | 2001-08-07 | The University Of California | In vitro and in vivo assay for agents which treat mucus hypersecretion |
| JP2003523166A (ja) | 1998-09-29 | 2003-08-05 | ガミダ セル リミテッド | 幹細胞および前駆細胞の増殖と分化を制御する方法 |
| GB9823930D0 (en) | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
| CA2450402A1 (en) | 1998-12-22 | 2000-06-29 | Genentech, Inc. | Methods and compositions for inhibiting cancer cell growth comprising pro224 |
| CZ303703B6 (cs) | 1998-12-23 | 2013-03-20 | Pfizer Inc. | Monoklonální protilátka nebo její antigen-vázající fragment, farmaceutická kompozice obsahující tuto protilátku nebo fragment, bunecná linie produkující tuto protilátku nebo fragment, zpusob prípravy této protilátky, izolovaná nukleová kyselina kóduj |
| AU778759B2 (en) | 1998-12-23 | 2004-12-16 | Genentech Inc. | IL-1 related polypeptides |
| US7109003B2 (en) * | 1998-12-23 | 2006-09-19 | Abgenix, Inc. | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 |
| US6682736B1 (en) | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
| JP4712975B2 (ja) | 1999-01-12 | 2011-06-29 | ケンブリッジ エンタープライズ リミティド | 炎症反応を阻害又は増強するための組成物及び方法 |
| US6329510B1 (en) | 1999-01-29 | 2001-12-11 | Millennium Pharmaceuticals, Inc. | Anti-CCR1 antibodies and methods of use therefor |
| AU2907200A (en) * | 1999-02-05 | 2000-08-25 | Jens-Ulrich Bulow | Human polyclonal antibodies from genetically engineered animals |
| EP1604997A1 (en) * | 1999-02-05 | 2005-12-14 | Therapeutic Human Polyclonals, Inc. | Human polyclonal antibodies from transgenic nonhuman animals |
| US6303321B1 (en) * | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| US6914128B1 (en) | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
| US7820161B1 (en) * | 1999-05-07 | 2010-10-26 | Biogen Idec, Inc. | Treatment of autoimmune diseases |
| US20040023874A1 (en) * | 2002-03-15 | 2004-02-05 | Burgess Catherine E. | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| SK16522001A3 (sk) * | 1999-05-14 | 2002-10-08 | Imclone Systems Incorporated | Liečivo na inhibíciu rastu refraktérnych nádorov |
| US20040229779A1 (en) * | 1999-05-14 | 2004-11-18 | Ramesh Kekuda | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| US6974684B2 (en) * | 2001-08-08 | 2005-12-13 | Curagen Corporation | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| DE60042066D1 (de) | 1999-05-28 | 2009-06-04 | Genentech Inc | Chimärische dr4 antikörper und ihre verwendung |
| US20040067490A1 (en) * | 2001-09-07 | 2004-04-08 | Mei Zhong | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| US6946129B1 (en) | 1999-06-08 | 2005-09-20 | Seattle Genetics, Inc. | Recombinant anti-CD40 antibody and uses thereof |
| US7534605B2 (en) * | 1999-06-08 | 2009-05-19 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases |
| US6833268B1 (en) | 1999-06-10 | 2004-12-21 | Abgenix, Inc. | Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions |
| DE60043322D1 (de) | 1999-06-15 | 2009-12-24 | Genentech Inc | Sekretierte und Transmembran-Polypeptide sowie Nukleinsäuren zu deren Kodierung |
| CN100340575C (zh) | 1999-06-25 | 2007-10-03 | 杰南技术公司 | 人源化抗ErbB2抗体及其在制备药物中的应用 |
| EP2283867B1 (en) | 1999-06-25 | 2014-05-21 | ImmunoGen, Inc. | Methods of treatment using anti-ERBB antibody-maytansinoid conjugates |
| JP5138851B2 (ja) * | 1999-06-28 | 2013-02-06 | オクラホマ メディカル リサーチ ファウンデーション | 触媒的に活性な組換えメマプシンおよびその使用方法 |
| US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| EP1792991A1 (en) * | 1999-08-24 | 2007-06-06 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| KR100510795B1 (en) * | 1999-08-31 | 2005-08-30 | Compositions and Methods for the Treatment of Tumor | |
| US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
| US20070111259A1 (en) * | 1999-10-02 | 2007-05-17 | Medarex, Inc. | Human antibodies |
| US6794132B2 (en) | 1999-10-02 | 2004-09-21 | Biosite, Inc. | Human antibodies |
| US7135287B1 (en) | 1999-10-02 | 2006-11-14 | Biosite, Inc. | Human antibodies |
| CA2383642C (en) | 1999-10-14 | 2014-03-25 | Clontech Laboratories, Inc. | Anthozoa derived chromophores/fluorophores and methods for using the same |
| KR100874280B1 (ko) * | 1999-10-20 | 2008-12-18 | 제넨테크, 인크. | Ｔ 헬퍼 세포 매개 질환의 치료를 위한 ｔ 세포 분화의조절 |
| US7078382B1 (en) | 1999-11-02 | 2006-07-18 | Genentech, Inc. | Modulation of eNOS activity and therapeutic uses thereof |
| US7820878B2 (en) * | 1999-11-19 | 2010-10-26 | Kyowa Hakko Kirin Co., Ltd. | Production of ungulates, preferably bovines that produce human immunoglobulins |
| AU1777301A (en) * | 1999-11-19 | 2001-05-30 | Hematech, Llc | Production of ungulates, preferably bovines that produce human immunoglobulins |
| US7074983B2 (en) * | 1999-11-19 | 2006-07-11 | Kirin Beer Kabushiki Kaisha | Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin |
| US7414170B2 (en) * | 1999-11-19 | 2008-08-19 | Kirin Beer Kabushiki Kaisha | Transgenic bovines capable of human antibody production |
| CA2494705A1 (en) | 1999-12-01 | 2001-06-07 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US6680209B1 (en) * | 1999-12-06 | 2004-01-20 | Biosite, Incorporated | Human antibodies as diagnostic reagents |
| EP2258848B1 (en) | 1999-12-23 | 2014-03-05 | Genentech, Inc. | Il-17 homologous polypeptide and therapeutic uses thereof |
| NZ520095A (en) | 2000-01-13 | 2004-05-28 | Genentech Inc | Novel Stra6 polypeptides, nucleic acids, antibodies, compositions and methods of treatments for inhibiting tumor cell growth |
| KR101111103B1 (ko) * | 2000-02-10 | 2012-02-13 | 아보트 러보러터리즈 | 사람 인터류킨-18에 결합하는 항체 및 이를 제조하고 사용하는 방법 |
| US6653448B1 (en) | 2000-03-29 | 2003-11-25 | Curagen Corporation | Wnt-7B-like polypeptides and nucleic acids encoding same |
| US6740520B2 (en) | 2000-03-21 | 2004-05-25 | Genentech, Inc. | Cytokine receptor and nucleic acids encoding the same |
| US20040086970A1 (en) * | 2000-03-22 | 2004-05-06 | Genentech, Inc. | Novel cytokine receptors and nucleic acids encoding the same |
| US7514239B2 (en) | 2000-03-28 | 2009-04-07 | Amgen Inc. | Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof |
| CN100390288C (zh) | 2000-04-11 | 2008-05-28 | 杰南技术公司 | 多价抗体及其应用 |
| US20010046496A1 (en) | 2000-04-14 | 2001-11-29 | Brettman Lee R. | Method of administering an antibody |
| US7632929B2 (en) * | 2000-04-20 | 2009-12-15 | The Board Of Trustees Of The University Of Arkansas | Methamphetamine-like hapten compounds, linkers, carriers and compositions and uses thereof |
| MXPA02010869A (es) * | 2000-05-08 | 2003-04-14 | Medarex Inc | Anticuerpos monoclonales humanos para celulas dendriticas. |
| US7560534B2 (en) | 2000-05-08 | 2009-07-14 | Celldex Research Corporation | Molecular conjugates comprising human monoclonal antibodies to dendritic cells |
| US6656700B2 (en) | 2000-05-26 | 2003-12-02 | Amersham Plc | Isoforms of human pregnancy-associated protein-E |
| US6686188B2 (en) * | 2000-05-26 | 2004-02-03 | Amersham Plc | Polynucleotide encoding a human myosin-like polypeptide expressed predominantly in heart and muscle |
| US7439016B1 (en) * | 2000-06-15 | 2008-10-21 | Digene Corporation | Detection of nucleic acids by type-specific hybrid capture method |
| WO2001097858A2 (en) | 2000-06-20 | 2001-12-27 | Idec Pharmaceuticals Corporation | Cold anti-cd20 antibody/radiolabeled anti-cd22 antibody combination |
| CA2648051A1 (en) | 2000-06-23 | 2002-01-03 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| EP2042597B1 (en) | 2000-06-23 | 2014-05-07 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| JP2004519205A (ja) | 2000-06-28 | 2004-07-02 | アムジェン インコーポレイテッド | 胸腺間質リンホポイエチンレセプター分子およびその使用 |
| US20040023259A1 (en) * | 2000-07-26 | 2004-02-05 | Luca Rastelli | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| ATE415978T1 (de) | 2000-07-27 | 2008-12-15 | Genentech Inc | Sequentielle verabreichung von cpt-11 und apo-2l polypeptid |
| CA2634294A1 (en) * | 2000-08-03 | 2002-02-14 | Therapeutic Human Polyclonals, Inc. | Production of humanized antibodies in transgenic animals |
| US6984522B2 (en) * | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| US6902734B2 (en) | 2000-08-07 | 2005-06-07 | Centocor, Inc. | Anti-IL-12 antibodies and compositions thereof |
| UA81743C2 (uk) | 2000-08-07 | 2008-02-11 | Центокор, Инк. | МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ |
| US7288390B2 (en) | 2000-08-07 | 2007-10-30 | Centocor, Inc. | Anti-dual integrin antibodies, compositions, methods and uses |
| US20030114410A1 (en) | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
| WO2002011677A2 (en) * | 2000-08-09 | 2002-02-14 | Imclone Systems Incorporated | Treatment of hyperproliferative diseases with epidermal growth factor receptor antagonists |
| GB0020685D0 (en) | 2000-08-22 | 2000-10-11 | Novartis Ag | Organic compounds |
| DE60136281D1 (de) | 2000-08-24 | 2008-12-04 | Genentech Inc | Methode zur inhibierung von il-22 induziertem pap1 |
| JP4932125B2 (ja) | 2000-08-25 | 2012-05-16 | ビーエーエスエフ プラント サイエンス ゲーエムベーハー | 新規プレニルプロテアーゼをコードする植物ポリヌクレオチド |
| EP1944317A3 (en) | 2000-09-01 | 2008-09-17 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| MXPA03002262A (es) * | 2000-09-18 | 2003-10-15 | Idec Pharma Corp | Terapia de combinacion para tratamiento de enfermedades autoinmunes usando una combinacion de anticuerpos inmunorreguladores/supresores de celulas b. |
| US20020115058A1 (en) * | 2000-09-22 | 2002-08-22 | Pedersen Finn Skou | Methods for diagnosis and treatment of diseases associated with altered expression of Pik3r1 |
| US20030044803A1 (en) * | 2000-09-22 | 2003-03-06 | Pedersen Finn Skou | Methods for diagnosis and treatment of diseases associated with altered expression of JAK1 |
| US20030077590A1 (en) * | 2000-09-22 | 2003-04-24 | Pedersen Finn Skou | Methods for diagnosis and treatment of diseases associated with altered expression of neurogranin |
| US20020123474A1 (en) * | 2000-10-04 | 2002-09-05 | Shannon Mark E. | Human GTP-Rho binding protein2 |
| PT1324776E (pt) | 2000-10-12 | 2009-12-23 | Genentech Inc | Formulações de proteína concentradas de viscosidade reduzida |
| US7393532B1 (en) | 2000-10-18 | 2008-07-01 | Genentech, Inc. | Modulation of T cell differentiation for the treatment of T helper cell mediated diseases |
| US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7041870B2 (en) | 2000-11-30 | 2006-05-09 | Medarex, Inc. | Transgenic transchromosomal rodents for making human antibodies |
| US7700274B2 (en) * | 2000-12-22 | 2010-04-20 | Sagres Discovery, Inc. | Compositions and methods in cancer associated with altered expression of KCNJ9 |
| US7645441B2 (en) * | 2000-12-22 | 2010-01-12 | Sagres Discovery Inc. | Compositions and methods in cancer associated with altered expression of PRLR |
| ATE502106T1 (de) * | 2000-12-22 | 2011-04-15 | Kyowa Hakko Kirin Co Ltd | Verfahren zur klonierung von nichtmenschliche säugern unter verwendung von reprogrammiertem donorchromatin oder donorzellen |
| US20030099963A1 (en) * | 2000-12-22 | 2003-05-29 | Morris David W. | Novel compositions and methods in cancer associated with altered expression of TBX21 |
| US7820447B2 (en) | 2000-12-22 | 2010-10-26 | Sagres Discovery Inc. | Compositions and methods for cancer |
| US7892730B2 (en) * | 2000-12-22 | 2011-02-22 | Sagres Discovery, Inc. | Compositions and methods for cancer |
| US20020142397A1 (en) * | 2000-12-22 | 2002-10-03 | Philippe Collas | Methods for altering cell fate |
| US20030232334A1 (en) | 2000-12-22 | 2003-12-18 | Morris David W. | Novel compositions and methods for cancer |
| US20030165878A1 (en) * | 2000-12-22 | 2003-09-04 | Morris David W. | Novel compositions and methods in cancer associated with altered expression of MCM3AP |
| US20030087252A1 (en) * | 2000-12-22 | 2003-05-08 | Morris David W. | Novel compositions and methods in cancer associated with altered expression of PRDM11 |
| US7491534B2 (en) * | 2000-12-22 | 2009-02-17 | Kirin Holdings Kabushiki Kaisha | Methods for altering cell fate to generate T-cells specific for an antigen of interest |
| JP2004531217A (ja) * | 2001-01-05 | 2004-10-14 | ファイザー・インク | インスリン様成長因子ｉ受容体に対する抗体 |
| US6964849B2 (en) | 2001-01-11 | 2005-11-15 | Curagen Corporation | Proteins and nucleic acids encoding same |
| US20040043928A1 (en) * | 2001-08-02 | 2004-03-04 | Ramesh Kekuda | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| US20020159996A1 (en) | 2001-01-31 | 2002-10-31 | Kandasamy Hariharan | Use of CD23 antagonists for the treatment of neoplastic disorders |
| US20080008704A1 (en) * | 2001-03-16 | 2008-01-10 | Mark Rubin | Methods of treating colorectal cancer with anti-epidermal growth factor antibodies |
| AU2002254431A1 (en) * | 2001-03-27 | 2002-10-08 | M. Eric Gershwin | Antibodies against autoantigens of primary biliary cirrhosis and methods of making and using them |
| WO2002085924A2 (en) * | 2001-04-23 | 2002-10-31 | Abgenix, Inc. | ANTI-α3(IV)NC1 MONOCLONAL ANTIBODIES AND ANIMAL MODEL FOR HUMAN ANTI-GLOMERULAR BASEMENT MEMBRANE AUTOANTIBODY DISEASE |
| GB0110029D0 (en) * | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
| JP4115281B2 (ja) | 2001-05-11 | 2008-07-09 | キリンファーマ株式会社 | ヒト抗体λ軽鎖遺伝子を含むヒト人工染色体、および子孫伝達可能な該ヒト人工染色体を含む非ヒト動物 |
| US7304034B2 (en) | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
| JP2005512507A (ja) * | 2001-05-15 | 2005-05-12 | ノース・ショア−ロング・アイランド・ジューイッシュ・リサーチ・インスティテュート | 抗炎症剤としてのｈｍｇフラグメントの使用 |
| US20070160576A1 (en) | 2001-06-05 | 2007-07-12 | Genentech, Inc. | IL-17A/F heterologous polypeptides and therapeutic uses thereof |
| CA2451239A1 (en) | 2001-06-20 | 2003-01-03 | Genentech, Inc. | Antibodies against tumor-associated antigenic taget (tat) polypeptides |
| GB0115256D0 (en) | 2001-06-21 | 2001-08-15 | Babraham Inst | Mouse light chain locus |
| US20030013081A1 (en) | 2001-06-26 | 2003-01-16 | Olson William C. | Uses of DC-SIGN and DC-SIGNR for inhibiting hepatitis C virus infection |
| US20030087274A1 (en) * | 2001-07-05 | 2003-05-08 | Anderson David W. | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| US20040029790A1 (en) * | 2001-07-05 | 2004-02-12 | Meera Patturajan | Novel human proteins, polynucleotides encoding them and methods of using the same |
| US20040030096A1 (en) * | 2001-08-02 | 2004-02-12 | Linda Gorman | Novel human proteins, polynucleotides encoding them and methods of using the same |
| US20040235068A1 (en) * | 2001-09-05 | 2004-11-25 | Levinson Arthur D. | Methods for the identification of polypeptide antigens associated with disorders involving aberrant cell proliferation and compositions useful for the treatment of such disorders |
| NZ531674A (en) | 2001-09-18 | 2009-03-31 | Genentech Inc | Compositions and methods for the diagnosis and treatment of tumor |
| US7981863B2 (en) | 2001-09-19 | 2011-07-19 | Neuronova Ab | Treatment of Parkinson's disease with PDGF |
| US20070098728A1 (en) * | 2001-09-24 | 2007-05-03 | Pedersen Finn S | Novel compositions and methods in cancer |
| US20030199442A1 (en) * | 2001-10-09 | 2003-10-23 | Alsobrook John P. | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| US7521053B2 (en) | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US20050123925A1 (en) | 2002-11-15 | 2005-06-09 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| US20040166490A1 (en) * | 2002-12-17 | 2004-08-26 | Morris David W. | Novel therapeutic targets in cancer |
| US20040161776A1 (en) | 2001-10-23 | 2004-08-19 | Maddon Paul J. | PSMA formulations and uses thereof |
| JP5355839B2 (ja) | 2001-10-23 | 2013-11-27 | ピーエスエムエー デベロプメント カンパニー， エル．エル．シー． | Ｐｓｍａ抗体およびタンパク質マルチマー |
| US20040126762A1 (en) * | 2002-12-17 | 2004-07-01 | Morris David W. | Novel compositions and methods in cancer |
| AR039067A1 (es) | 2001-11-09 | 2005-02-09 | Pfizer Prod Inc | Anticuerpos para cd40 |
| US20040197778A1 (en) * | 2002-12-26 | 2004-10-07 | Sagres Discovery, Inc. | Novel compositions and methods in cancer |
| CA2468565C (en) | 2001-11-30 | 2014-06-03 | Abgenix, Inc. | Transgenic animals bearing human iglambda light chain genes |
| US20040180344A1 (en) * | 2003-03-14 | 2004-09-16 | Morris David W. | Novel therapeutic targets in cancer |
| US20060040262A1 (en) * | 2002-12-27 | 2006-02-23 | Morris David W | Novel compositions and methods in cancer |
| WO2003048298A2 (en) * | 2001-12-05 | 2003-06-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Nanoparticles containing polymeric nucleic acid homologs, pharmaceutical compositions and articles of manufacture containing same and methods of use thereof |
| IL147138A0 (en) | 2001-12-17 | 2002-08-14 | Yeda Res & Dev | Methods of and pharmaceutical compositions for modulating cell adhesion, migration and extravasation |
| ATE439368T1 (de) | 2001-12-19 | 2009-08-15 | Univ Chicago | Schnellreifende fluoreszierende proteine und verfahren zu deren anwendung |
| US6578724B1 (en) * | 2001-12-29 | 2003-06-17 | United States Can Company | Connector for use in packaging aerosol containers |
| KR100623128B1 (ko) | 2002-01-02 | 2006-09-14 | 제넨테크, 인크. | 종양의 진단 및 치료 방법 및 이를 위한 조성물 |
| IL152904A0 (en) | 2002-01-24 | 2003-06-24 | Gamida Cell Ltd | Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations |
| WO2003062404A1 (en) | 2002-01-25 | 2003-07-31 | Gamida-Cell Ltd. | Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby |
| US20040052928A1 (en) * | 2002-09-06 | 2004-03-18 | Ehud Gazit | Peptides and methods using same for diagnosing and treating amyloid-associated diseases |
| US7462491B2 (en) * | 2002-01-31 | 2008-12-09 | Baylor College Of Medicine | Methods and compositions for diagnosis and monitoring of prostate cancer progression by detection of serum caveolin |
| US7781396B2 (en) * | 2002-01-31 | 2010-08-24 | Tel Aviv University Future Technology Development L.P. | Peptides directed for diagnosis and treatment of amyloid-associated disease |
| US6992176B2 (en) | 2002-02-13 | 2006-01-31 | Technion Research & Development Foundation Ltd. | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
| US7662924B2 (en) | 2002-02-22 | 2010-02-16 | The Board Of Trustees Of The University Of Illinois | Beta chain-associated regulator of apoptosis |
| CA2476518A1 (en) | 2002-02-22 | 2003-09-04 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| AU2003217693A1 (en) * | 2002-02-22 | 2003-09-09 | Board Of Trustees Of The University Of Illinois | Beta chain-associated regulator of apoptosis |
| GB0205022D0 (en) | 2002-03-04 | 2002-04-17 | Univ Cambridge Tech | Materials and methods for the treatment of cns damage |
| EP1501855A4 (en) | 2002-03-21 | 2006-02-22 | Sagres Discovery Inc | NEW COMPOSITIONS AND METHODS FOR CANCER |
| JP2005530490A (ja) * | 2002-03-29 | 2005-10-13 | シェーリング コーポレイション | インターロイキン−５に対するヒトモノクローナル抗体および方法およびこれを含む組成物 |
| US20040162236A1 (en) * | 2002-04-01 | 2004-08-19 | John Alsobrook | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| EP2314316A1 (en) | 2002-04-05 | 2011-04-27 | Amgen, Inc | Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors |
| US7357928B2 (en) | 2002-04-08 | 2008-04-15 | University Of Louisville Research Foundation, Inc. | Method for the diagnosis and prognosis of malignant diseases |
| US7541150B2 (en) * | 2002-04-08 | 2009-06-02 | University Of Louisville Research Foundation, Inc | Method for the diagnosis and prognosis of malignant diseases |
| PT1496939E (pt) | 2002-04-09 | 2007-11-22 | Sanofi Pasteur Ltd | ''ácido nucleico de cea modificado e vectores de expressão'' |
| CA2481515C (en) | 2002-04-10 | 2013-10-01 | Genentech, Inc. | Anti-her2 antibody variants |
| AU2003234736B2 (en) | 2002-04-12 | 2008-09-25 | E. R. Squibb & Sons, L.L.C. | Methods of treatment using CTLA-4 antibodies |
| MXPA04010092A (es) | 2002-04-16 | 2004-12-13 | Genentech Inc | Composiciones y metodos para el diagnostico y tratamiento de tumores. |
| US20040016010A1 (en) * | 2002-04-17 | 2004-01-22 | Marion Kasaian | IL-21 receptor knockout animal and methods of use thereof |
| JP4662719B2 (ja) | 2002-04-19 | 2011-03-30 | ザ ガバニング カウンシル オブ ザ ユニバーシティ オブ トロント | アルツハイマー病の処置のための免疫学的方法および組成物 |
| EP2316922B1 (en) | 2002-05-24 | 2013-05-22 | Merck Sharp & Dohme Corp. | Neutralizing human anti-IGFR antibody |
| US20050121254A1 (en) * | 2002-05-29 | 2005-06-09 | Marcus Hofmann | Device for establishing noise in a motor vehicle |
| EP2305710A3 (en) | 2002-06-03 | 2013-05-29 | Genentech, Inc. | Synthetic antibody phage libraries |
| US20050221326A1 (en) * | 2002-06-12 | 2005-10-06 | Avi Orr-Urtreger | Oligonucleotides antibodies and kits including same for treating prostate cancer and determining predisposition thereto |
| US7585501B2 (en) | 2002-06-14 | 2009-09-08 | Stowers Institute For Medical Research | Compositions and methods for treating kidney disease |
| WO2004003554A1 (en) * | 2002-06-26 | 2004-01-08 | University Of Louisville Research Foundation, Inc. | A method for the detection of apoptosis |
| US20040138114A1 (en) | 2002-07-08 | 2004-07-15 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| KR20120068769A (ko) | 2002-07-15 | 2012-06-27 | 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 | 음이온성 인지질 및 아미노인지질에 결합하는 선택된 항체 및 치료하는데 있어서 이의 용도 |
| NZ537660A (en) | 2002-07-15 | 2008-12-24 | Genentech Inc | Methods for identifying tumors that are responsive to treatment with anti-ErbB2 antibodies |
| ZA200500480B (en) | 2002-07-15 | 2006-10-25 | Wyeth Corp | Methods and compositions for modulating T helper (TH) cell development and function |
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| PT2314629E (pt) | 2002-07-18 | 2014-01-22 | Merus B V | Produção recombinante de misturas de anticorpos |
| TWI289668B (en) | 2002-09-06 | 2007-11-11 | Amgen Inc | Therapeutic human anti-IL-1R1 monoclonal antibody |
| US20080260744A1 (en) * | 2002-09-09 | 2008-10-23 | Omeros Corporation | G protein coupled receptors and uses thereof |
| JP2006516383A (ja) | 2002-09-09 | 2006-07-06 | デイナ−ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｂｈ３ペプチドおよびその使用方法 |
| CA2498264A1 (en) * | 2002-09-09 | 2004-05-13 | Nura, Inc. | G protein coupled receptors and uses thereof |
| EP1539228B1 (en) | 2002-09-11 | 2010-12-29 | Genentech, Inc. | Novel composition and methods for the treatment of immune related diseases |
| EP2116551A1 (en) | 2002-09-11 | 2009-11-11 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| AU2003291625B2 (en) | 2002-09-16 | 2009-10-08 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| EP2500438A3 (en) | 2002-09-25 | 2012-11-28 | Genentech, Inc. | Novel compositions and methods for the treatment of psoriasis |
| PL211654B1 (pl) * | 2002-10-08 | 2012-06-29 | Rinat Neuroscience Corp | Przeciwciało skierowane przeciwko NGF do zastosowania w leczeniu bólu pooperacyjnego, zastosowanie tego przeciwciała do wytwarzania leku do leczenia bólu pooperacyjnego i kompozycja farmaceutyczna zawierająca przeciwciało skierowane przeciwko NGF do zastosowania w leczeniu bólu pooperacyjnego |
| US7255860B2 (en) | 2002-10-08 | 2007-08-14 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody |
| WO2004032868A2 (en) * | 2002-10-09 | 2004-04-22 | Rinat Neuroscience Corp. | Methods of treating alzheimer's disease using antibodies directed against amyloid beta peptide and compositions thereof |
| US7396913B2 (en) * | 2002-10-14 | 2008-07-08 | Abbott Laboratories | Erythropoietin receptor binding antibodies |
| AU2003285874A1 (en) | 2002-10-16 | 2004-05-04 | Amgen Inc. | HUMAN ANTI-IFN-Gamma NEUTRALIZING ANTIBODIES AS SELECTIVE IFN-Gamma PATHWAY INHIBITORS |
| EP2330130B1 (en) | 2002-10-17 | 2014-08-27 | Genmab A/S | Human monoclonal antibodies against CD20 |
| JP2006517785A (ja) | 2002-10-29 | 2006-08-03 | ジェネンテック・インコーポレーテッド | 免疫関連疾患の治療のための新規組成物と方法 |
| WO2004044161A2 (en) * | 2002-11-06 | 2004-05-27 | Fraunhofer Usa | Expression of foreign sequences in plants using trans-activation system |
| EP1581169A4 (en) | 2002-11-08 | 2008-09-17 | Genentech Inc | COMPOSITIONS AND METHODS FOR TREATING DISEASES RELATED TO NATURAL K CELLS |
| MXPA05004870A (es) * | 2002-11-08 | 2005-11-04 | Hematech Llc | Ungulados transgenicos que tienen actividad reducida de la proteina prion y sus usos. |
| US7692063B2 (en) * | 2002-11-12 | 2010-04-06 | Ibio, Inc. | Production of foreign nucleic acids and polypeptides in sprout systems |
| US7683238B2 (en) | 2002-11-12 | 2010-03-23 | iBio, Inc. and Fraunhofer USA, Inc. | Production of pharmaceutically active proteins in sprouted seedlings |
| US20060009378A1 (en) | 2002-11-14 | 2006-01-12 | Itshak Golan | Novel galectin sequences and compositions and methods utilizing same for treating or diagnosing arthritis and other chronic inflammatory diseases |
| DK1572106T3 (da) | 2002-11-15 | 2010-08-23 | Novartis Vaccines & Diagnostic | Fremgangsmåde til forebyggelse og behandling af cancermetastase og knogletab forbundet med cancermetastase |
| CA2505682A1 (en) * | 2002-11-20 | 2004-06-03 | Kevin J. Tracey | Use of hmgb polypeptides for increasing immune responses |
| EP2311870A1 (en) | 2002-11-26 | 2011-04-20 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| CA2506629A1 (en) * | 2002-11-27 | 2004-06-17 | Gtc Biotherapeutics, Inc. | Modified antibodies stably produced in milk and methods of producing same |
| RU2377253C2 (ru) | 2002-12-02 | 2009-12-27 | Амген Фремонт,Инк. | Антитела, специфичные к фактору некроза опухолей, и их применение |
| US7491699B2 (en) * | 2002-12-09 | 2009-02-17 | Ramot At Tel Aviv University Ltd. | Peptide nanostructures and methods of generating and using the same |
| JP4739763B2 (ja) | 2002-12-16 | 2011-08-03 | ゲンマブ エー／エス | インターロイキン８（ｉｌ−８）に対するヒトモノクローナル抗体 |
| ES2326080T3 (es) * | 2002-12-23 | 2009-09-30 | Rinat Neuroscience Corp. | Metodos para tratar neuropatia sensorial inducida por taxol. |
| US7569364B2 (en) | 2002-12-24 | 2009-08-04 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
| NZ540730A (en) | 2002-12-24 | 2010-09-30 | Rinat Neuroscience Corp | Anti-NGF antibodies and methods using same |
| US9498530B2 (en) | 2002-12-24 | 2016-11-22 | Rinat Neuroscience Corp. | Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same |
| ATE426575T1 (de) | 2003-01-07 | 2009-04-15 | Univ Ramot | Peptidenanostrukturen die fremdmaterial enthalten,und verfahren zur herstellung derselben |
| US7259002B2 (en) * | 2003-01-21 | 2007-08-21 | Bristol-Myers Squibb Company | Polynucleotide encoding a novel acyl coenzyme A, monoacylglycerol acyltransferase-3 (MGAT3), and uses thereof |
| EP1585768A2 (en) * | 2003-01-23 | 2005-10-19 | Genentech, Inc. | Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture |
| CA2514062A1 (en) * | 2003-01-27 | 2004-08-12 | Biogen Idec Ma Inc. | Compositions and methods for treating cancer using igsf9 and liv-1 |
| ZA200506202B (en) * | 2003-01-31 | 2006-10-25 | Celldex Therapeutics Inc | Antibody vaccine conjugates and uses therefor |
| US9259459B2 (en) * | 2003-01-31 | 2016-02-16 | Celldex Therapeutics Inc. | Antibody vaccine conjugates and uses therefor |
| WO2004070016A2 (en) | 2003-02-03 | 2004-08-19 | Fraunhofer Usa Inc. | System for expression of genes in plants |
| EP1592708A2 (en) | 2003-02-14 | 2005-11-09 | Sagres Discovery, Inc. | Therapeutic gpcr targets in cancer |
| US20070218071A1 (en) * | 2003-09-15 | 2007-09-20 | Morris David W | Novel therapeutic targets in cancer |
| US7767387B2 (en) * | 2003-06-13 | 2010-08-03 | Sagres Discovery, Inc. | Therapeutic targets in cancer |
| WO2004071508A1 (en) * | 2003-02-14 | 2004-08-26 | Medical Research Council | Ip receptor antagonists for the treatment of pathological uterine conditions |
| US20040170982A1 (en) | 2003-02-14 | 2004-09-02 | Morris David W. | Novel therapeutic targets in cancer |
| PL379983A1 (pl) | 2003-02-19 | 2006-11-27 | Rinat Neuroscience Corp. | Sposoby leczenia bólu polegające na podaniu antagonisty czynnika wzrostu nerwów i niesteroidowego leku przeciwzapalnego oraz zawierające je kompozycje |
| US7723075B2 (en) * | 2003-02-21 | 2010-05-25 | The Queens's Medical Center | Methods of screening for TRPM5 modulators |
| GB2398784B (en) * | 2003-02-26 | 2005-07-27 | Babraham Inst | Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal |
| US8017113B2 (en) | 2003-03-12 | 2011-09-13 | Rappaport Family Institute For Research In The Medical Sciences | Compositions and methods for diagnosing and treating an inflammation |
| US7741065B2 (en) * | 2003-03-13 | 2010-06-22 | Ramot At Tel Aviv University Ltd. | Non-invasive marker for liver function and disease |
| JP2007525434A (ja) | 2003-03-19 | 2007-09-06 | アブジェニックス インコーポレイテッド | Ｔ細胞、免疫グロブリンドメインおよびムチンドメイン１（ｔｉｍ−１）抗原に対する抗体およびその使用。 |
| US20070014786A1 (en) * | 2003-03-20 | 2007-01-18 | Rinat Neuroscience Corp. | Methods for treating taxol-induced gut disorder |
| WO2004087042A2 (en) | 2003-04-04 | 2004-10-14 | Yeda Research And Development Co. Ltd. | Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins |
| ZA200507757B (en) | 2003-04-04 | 2007-01-31 | Genentech Inc | High concentration antibody and protein formulations |
| MXPA05010778A (es) | 2003-04-09 | 2005-12-12 | Genentech Inc | Terapia para enfermedad autoinmune en un paciente con una respuesta inadecuada a un inhibidor tnf-alfa. |
| US8613922B2 (en) | 2003-04-24 | 2013-12-24 | The University Of North Carolina At Chapel Hill | Methods for inhibiting diabetic retinopathy with an antibody against integrin associated protein (IAP) |
| EP1633317A4 (en) | 2003-05-16 | 2008-08-20 | Intermune Inc | Synthetic chemokine receptor ligands and methods of use therefor |
| BRPI0410562B8 (pt) | 2003-05-22 | 2021-05-25 | Fralunhofer Usa Inc | proteína de veículo e seu método de produção em uma planta, ácido nucleico isolado, vetor de expressão e célula hospedeira |
| KR20160114727A (ko) | 2003-05-30 | 2016-10-05 | 제넨테크, 인크. | 항-ｖｅｇｆ 항체를 사용한 치료 |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| CA2526080A1 (en) * | 2003-05-30 | 2005-01-06 | Genentech, Inc. | Polypeptides that bind an anti-tissue factor antibody and uses thereof |
| US9708410B2 (en) | 2003-05-30 | 2017-07-18 | Janssen Biotech, Inc. | Anti-tissue factor antibodies and compositions |
| EP2395017A3 (en) | 2003-05-30 | 2012-12-19 | Merus B.V. | Design and use of paired variable regions of specific binding molecules |
| EP1629001A2 (en) | 2003-06-05 | 2006-03-01 | Genentech, Inc. | Blys antagonists and uses thereof |
| ATE425463T1 (de) | 2003-06-06 | 2009-03-15 | Genentech Inc | Modulation der wechselwirkung zwischen hgf-beta- kette und c-met |
| US7696169B2 (en) * | 2003-06-06 | 2010-04-13 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| JP2007501948A (ja) | 2003-06-13 | 2007-02-01 | ユニバーシティー オブ ピッツバーグ | 免疫疾患、血液疾患および炎症性疾患のモニタリング |
| KR20160003332A (ko) | 2003-06-27 | 2016-01-08 | 암젠 프레몬트 인코포레이티드 | 상피 성장 인자 수용체의 결실 돌연변이체 지향 항체 및 그 용도 |
| EP2719394B1 (en) | 2003-06-30 | 2015-07-29 | Tel Aviv University Future Technology Development L.P. | Peptides for treating amyloid-associated diseases |
| MXPA06000347A (es) | 2003-07-08 | 2006-03-28 | Genentech Inc | Polipeptidos heterologos il-17 a/f y usos terapeuticos de los mismos. |
| IL161903A0 (en) * | 2003-07-17 | 2005-11-20 | Gamida Cell Ltd | Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs |
| PL1648998T3 (pl) | 2003-07-18 | 2015-03-31 | Amgen Inc | Specyficzne czynniki wiążące czynnik wzrostu hepatocytów |
| US20050085420A1 (en) * | 2003-07-22 | 2005-04-21 | Stanley Korsmeyer | Method of modulating apoptosis and compositions thereof |
| HN2004000285A (es) * | 2003-08-04 | 2006-04-27 | Pfizer Prod Inc | ANTICUERPOS DIRIGIDOS A c-MET |
| EP1659918B1 (en) | 2003-08-08 | 2009-01-14 | Amgen Fremont Inc. | Antibodies directed to parathyroid hormone (pth) and uses thereof |
| WO2005019258A2 (en) | 2003-08-11 | 2005-03-03 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
| WO2005026209A2 (en) * | 2003-09-11 | 2005-03-24 | Critical Therapeutics, Inc. | Monoclonal antibodies against hmgb1 |
| WO2005027901A1 (en) | 2003-09-25 | 2005-03-31 | Tel Aviv University Future Technology Development L.P. | Compositions and methods using same for treating amyloid-associated diseases |
| US20070281896A1 (en) * | 2003-09-30 | 2007-12-06 | Morris David W | Novel compositions and methods in cancer |
| WO2005031362A2 (en) * | 2003-10-02 | 2005-04-07 | Ramot At Tel Aviv University Ltd. | Novel antibacterial agents and methods of identifying and utilizing same |
| IL158287A0 (en) | 2003-10-07 | 2004-05-12 | Yeda Res & Dev | Antibodies to nik, their preparation and use |
| RS20110578A3 (en) | 2003-10-14 | 2016-02-29 | F. Hoffmann-La Roche Ltd | MACROCYCLIC CARBOXYLIC ACIDS AND ACYLSULPHONAMIDES AS HCV REPLICATION INHIBITORS |
| CA2762955A1 (en) | 2003-10-16 | 2005-04-28 | Imclone Llc | Fibroblast growth factor receptor-1 inhibitors and methods of treatment thereof |
| FR2861255B1 (fr) * | 2003-10-24 | 2006-02-17 | Centre Nat Rech Scient | Mammifere non-humain transgenique pour la region constante de la chaine lourde des immunoglobulines humaines de classe a et ses applications. |
| IL158599A0 (en) * | 2003-10-26 | 2004-05-12 | Yeda Res & Dev | Methods of modulating hematopoiesis |
| NZ583292A (en) | 2003-11-06 | 2012-03-30 | Seattle Genetics Inc | Monomethylvaline compounds capable of conjugation to ligands |
| CA2544253A1 (en) * | 2003-11-12 | 2005-05-26 | Progenics Pharmaceuticals, Inc. | Novel sequences encoding hepatitis c virus glycoproteins |
| US7968684B2 (en) * | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| US20050100965A1 (en) | 2003-11-12 | 2005-05-12 | Tariq Ghayur | IL-18 binding proteins |
| CA2541709C (en) * | 2003-11-13 | 2013-06-04 | California Pacific Medical Center | Anti-pecam therapy for metastasis suppression |
| NZ596981A (en) | 2003-11-17 | 2013-10-25 | Genentech Inc | Compositions and methods for the treatment of tumor of hematopoietic origin |
| US7642341B2 (en) * | 2003-12-18 | 2010-01-05 | Merck Serono S.A. | Angiogenesis inhibiting molecules, their selection, production and their use in the treatment of cancer |
| EP1533617A1 (en) * | 2003-11-19 | 2005-05-25 | RMF Dictagene S.A. | Angiogenesis inhibiting molecules, their selection, production and their use in the treatment and diagnosis of cancer |
| US7750123B2 (en) * | 2003-11-25 | 2010-07-06 | Dana Farber Cancer Institute, Inc. | Antibodies against SARS-CoV and methods of use thereof |
| WO2005051423A2 (en) | 2003-11-30 | 2005-06-09 | Yeda Research And Development Co. Ltd | Methods and agents for immune modulation and methods for identifying immune modulators |
| KR20130133302A (ko) | 2003-12-10 | 2013-12-06 | 메다렉스, 인코포레이티드 | Ｉｐ―１０ 항체 및 그의 용도 |
| EP1711207B1 (en) | 2003-12-10 | 2012-11-28 | Medarex, Inc. | Interferon alpha antibodies and their uses |
| AU2003300896A1 (en) | 2003-12-10 | 2005-07-14 | Millennium Pharmaceuticals, Inc. | Humanized anti-ccr2 antibodies and methods of use |
| US7312320B2 (en) | 2003-12-10 | 2007-12-25 | Novimmune Sa | Neutralizing antibodies and methods of use thereof |
| CN1922208A (zh) | 2003-12-11 | 2007-02-28 | 健泰科生物技术公司 | 用于抑制c－met二聚化及活化的方法和组合物 |
| EA200601220A1 (ru) | 2003-12-23 | 2006-12-29 | Ринат Ньюросайенс Корп. | Анти-trkc антитела-агонисты и способы их применения |
| PL1704166T3 (pl) | 2004-01-07 | 2015-10-30 | Novartis Vaccines & Diagnostics Inc | Przeciwciała monoklonalne swoiste względem M-CSF i ich zastosowania |
| CA2552523C (en) | 2004-01-09 | 2019-11-26 | Pfizer Inc. | Monoclonal antibodies to mucosal addressin cell adhesion molecule(madcam) |
| PT2270045E (pt) | 2004-02-06 | 2015-04-08 | Univ Massachusetts | Anticorpos contra toxinas de clostridium difficile e utilizações dos mesmos |
| US7481997B1 (en) | 2004-02-12 | 2009-01-27 | Montana State University | Snow mountain virus genome sequence, virus-like particles and methods of use |
| DE602005018325D1 (de) | 2004-02-19 | 2010-01-28 | Genentech Inc | Antikörper mit korrigierten cdr |
| EP1769068B1 (en) * | 2004-02-20 | 2014-12-31 | iBio, Inc. | Systems and methods for clonal expression in plants |
| US20060174364A1 (en) * | 2004-03-01 | 2006-08-03 | Avigenics, Inc. | Artificial chromosomes and transchromosomic avians |
| US20060123504A1 (en) * | 2004-12-07 | 2006-06-08 | Avigenics, Inc. | Methods of producing polyclonal antibodies |
| EP1730196B1 (en) | 2004-03-12 | 2010-12-22 | Vasgene Therapeutics, Inc. | Antibodies binding to ephb4 for inhibiting angiogenesis and tumor growth |
| EP2418224A3 (en) | 2004-03-19 | 2013-07-24 | Amgen Inc. | Reducing the risk of human and anti-human antibodies through V gene manipulation |
| DK1735348T3 (da) * | 2004-03-19 | 2012-07-16 | Imclone Llc | Humant anti-epidermalt vækstfaktorreceptorantistof |
| US7625549B2 (en) | 2004-03-19 | 2009-12-01 | Amgen Fremont Inc. | Determining the risk of human anti-human antibodies in transgenic mice |
| ATE496142T1 (de) | 2004-03-23 | 2011-02-15 | Oncotherapy Science Inc | Verfahren zur diagnose von nicht-kleinzelligem lungenkrebs |
| MXPA06011199A (es) * | 2004-03-31 | 2007-04-16 | Genentech Inc | Anticuerpos anti-tgf-beta humanizados. |
| US7794713B2 (en) | 2004-04-07 | 2010-09-14 | Lpath, Inc. | Compositions and methods for the treatment and prevention of hyperproliferative diseases |
| ES2338344T3 (es) * | 2004-04-07 | 2010-05-06 | Rinat Neuroscience Corporation | Procedimiento de tratamiento del dolor de cancer de hueso mediante la administracion de una antagonista del factor de crecimiento neuronal. |
| JP4755174B2 (ja) | 2004-04-07 | 2011-08-24 | ザ ユニヴァーシティー オヴ シカゴ | 単量体赤色蛍光タンパク質 |
| DK1756571T3 (da) | 2004-04-09 | 2010-12-13 | Univ Pittsburgh | Fremgangsmåde i realtid til detektering af akut inflammatoriske tilstande |
| US20080038265A1 (en) * | 2004-04-09 | 2008-02-14 | Reilly Edward B | Antibodies to Erythropoietin Receptor and Uses Thereof |
| US20050227289A1 (en) | 2004-04-09 | 2005-10-13 | Reilly Edward B | Antibodies to erythropoietin receptor and uses thereof |
| US20060018902A1 (en) * | 2004-04-09 | 2006-01-26 | Reilly Edward B | Antibodies to erythropoietin receptor and uses thereof |
| WO2005100402A1 (en) | 2004-04-13 | 2005-10-27 | F.Hoffmann-La Roche Ag | Anti-p-selectin antibodies |
| US20150017671A1 (en) | 2004-04-16 | 2015-01-15 | Yaping Shou | Methods for detecting lp-pla2 activity and inhibition of lp-pla2 activity |
| RU2006140377A (ru) * | 2004-04-16 | 2008-05-27 | Дженентек, Инк. (Us) | Способ усиления уничтожения в-клеток |
| US20060002930A1 (en) * | 2004-04-16 | 2006-01-05 | Genentech, Inc. | Treatment of disorders |
| CN101014715A (zh) | 2004-04-22 | 2007-08-08 | 麒麟麦酒株式会社 | 转基因动物及其用途 |
| WO2005111612A1 (en) | 2004-05-11 | 2005-11-24 | University Of Pittsburgh | Diagnosing and monitoring inflammatory diseases by measuring complement components on white blood cells |
| EP1789453A2 (en) * | 2004-05-18 | 2007-05-30 | Genentech, Inc. | M13 virus major coat protein variants for c-terminal and bi-terminal display of a heterologous protein |
| EP1784427A2 (en) | 2004-06-01 | 2007-05-16 | Domantis Limited | Bispecific fusion antibodies with enhanced serum half-life |
| CN102973947A (zh) | 2004-06-01 | 2013-03-20 | 健泰科生物技术公司 | 抗体-药物偶联物和方法 |
| AU2005250499B2 (en) * | 2004-06-03 | 2011-12-08 | Novimmune S.A. | Anti-CD3 antibodies and methods of use thereof |
| EP1753455A2 (en) | 2004-06-04 | 2007-02-21 | Genentech, Inc. | Method for treating multiple sclerosis |
| ES2643237T3 (es) | 2004-06-21 | 2017-11-21 | E. R. Squibb & Sons, L.L.C. | Anticuerpos del receptor 1 de interferón alfa y sus usos |
| AU2005259221B2 (en) | 2004-07-01 | 2011-02-10 | Innate Pharma | Antibodies binding to receptors KIR2DL1, -2, 3 but not KIR2DS4 and their therapeutic use |
| US20090156471A1 (en) * | 2004-07-15 | 2009-06-18 | Ramot At Tel Aviv University Ltd. | Use of anti-amyloid agents for treating and typing pathogen infections |
| ME00226B (me) | 2004-07-15 | 2011-02-10 | Medarex Llc | Humana anti-ngf neutrališuća antitijela kao selektivni inhibitori ngf signalne kaskade |
| EP2322217A3 (en) * | 2004-07-16 | 2011-09-28 | Pfizer Products Inc. | Combination treatment for non-hematologic malignancies using an anti-IGF-1R antibody |
| US8604185B2 (en) | 2004-07-20 | 2013-12-10 | Genentech, Inc. | Inhibitors of angiopoietin-like 4 protein, combinations, and their use |
| US20060024677A1 (en) | 2004-07-20 | 2006-02-02 | Morris David W | Novel therapeutic targets in cancer |
| WO2006012373A2 (en) * | 2004-07-20 | 2006-02-02 | Critical Therapeutics, Inc. | Combination therapies of hmgb and complement inhibitors against inflammation |
| EP1771474B1 (en) * | 2004-07-20 | 2010-01-27 | Genentech, Inc. | Inhibitors of angiopoietin-like 4 protein, combinations, and their use |
| WO2006036291A2 (en) | 2004-07-30 | 2006-04-06 | Rinat Neuroscience Corp. | Antibodies directed against amyloid-beta peptide and methods using same |
| US8568637B2 (en) * | 2004-08-02 | 2013-10-29 | Ramot At Tel-Aviv University Ltd. | Method of forming a fiber made of peptide nanostructures |
| CA2574881C (en) | 2004-08-04 | 2013-01-08 | Amgen Inc. | Antibodies to dkk-1 |
| GB0417487D0 (en) | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
| US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
| EP1793816B1 (en) | 2004-08-19 | 2012-01-04 | Tel Aviv University Future Technology Development L.P. | Compositions for treating amyloid associated diseases |
| WO2006027780A2 (en) * | 2004-09-08 | 2006-03-16 | Ramot At Tel Aviv University Ltd. | Peptide nanostructures containing end-capping modified peptides and methods of generating and using the same |
| US20060051347A1 (en) | 2004-09-09 | 2006-03-09 | Winter Charles M | Process for concentration of antibodies and therapeutic products thereof |
| EP1799812A4 (en) | 2004-09-16 | 2009-09-09 | Gamida Cell Ltd | EX VIVO CULTIVATION METHODS OF STEM CELLS AND PRECURSOR BY CO-CULTURE WITH MESENCHYMAL CELLS |
| TWI309240B (en) * | 2004-09-17 | 2009-05-01 | Hoffmann La Roche | Anti-ox40l antibodies |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| DK1802334T3 (da) * | 2004-10-21 | 2012-10-15 | Genentech Inc | Fremgangsmåde til behandling af intraokulære, neovaskulære sygdomme |
| US7964706B2 (en) * | 2004-10-22 | 2011-06-21 | Medimmune, Llc | High affinity antibodies against HMGB1 and methods of use thereof |
| US20060117398A1 (en) * | 2004-10-22 | 2006-06-01 | Roland Buelow | Suppression of endogenous immunoglobulin expression |
| EP2527456B1 (en) * | 2004-10-22 | 2018-05-16 | Revivicor Inc. | Transgenic porcines lacking endogenous immunoglobulin light chain |
| US20080026457A1 (en) | 2004-10-22 | 2008-01-31 | Kevin Wells | Ungulates with genetically modified immune systems |
| US8129130B2 (en) | 2004-10-22 | 2012-03-06 | The Feinstein Institute For Medical Research | High affinity antibodies against HMGB1 and methods of use thereof |
| US7585504B2 (en) | 2004-10-22 | 2009-09-08 | Medimmune, Llc | High affinity antibodies against HMGB1 and methods of use thereof |
| CA2588087A1 (en) * | 2004-11-15 | 2006-05-18 | Obe Therapy Biotechnology S.A.S. | Methods of reducing body fat |
| JP2008520684A (ja) | 2004-11-17 | 2008-06-19 | アブジェニックス・インコーポレーテッド | Ｉｌ−１３に対する完全ヒトモノクローナル抗体 |
| GB0425713D0 (en) | 2004-11-23 | 2004-12-22 | Baker Matthew | Immunogencity testing and antibody selection methods |
| DE602005022928D1 (de) | 2004-11-30 | 2010-09-23 | Abgenix Inc | Antikörper gegen gpnmb und ihre verwendungen |
| EP2769990A3 (en) | 2004-12-02 | 2015-02-25 | Domantis Limited | Bispecific domain antibodies targeting serum albumin and GLP-1 or PYY |
| US20060177436A1 (en) * | 2004-12-16 | 2006-08-10 | Genentech, Inc. | Methods for Treating Autoimmune Disorders |
| AU2005319404B2 (en) | 2004-12-20 | 2011-10-20 | Amgen Fremont Inc. | Binding proteins specific for human Matriptase |
| US7973140B2 (en) | 2004-12-21 | 2011-07-05 | Medimmune Limited | Antibodies directed to angiopoietin-2 and uses thereof |
| DK1841793T3 (da) | 2005-01-07 | 2010-07-19 | Diadexus Inc | Ovr110-antistofsammensætninger og fremgangsmåder til anvendelse deraf |
| WO2006077407A2 (en) | 2005-01-20 | 2006-07-27 | Medical Research Council | Modulators of itch ubiquitinase activity |
| PL1846030T3 (pl) | 2005-01-21 | 2019-05-31 | Genentech Inc | Ustalone dawkowanie przeciwciał her |
| EP2361933A3 (en) | 2005-01-26 | 2012-05-02 | Amgen Fremont Inc. | Antibodies against interleukin-1 beta |
| US8029783B2 (en) | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
| PA8660701A1 (es) | 2005-02-04 | 2006-09-22 | Pfizer Prod Inc | Agonistas de pyy y sus usos |
| US7998695B2 (en) | 2005-02-10 | 2011-08-16 | Oncotherapy Science, Inc. | Method of diagnosing bladder cancer |
| US20080019905A9 (en) * | 2005-02-18 | 2008-01-24 | Strome Scott E | Method of using an anti-CD137 antibody as an agent for radioimmunotherapy or radioimmunodetection |
| EP1871807B1 (en) | 2005-02-18 | 2012-11-28 | Dana-Farber Cancer Institute, Inc. | Antibodies against cxcr4 and methods of use thereof |
| NZ590431A (en) | 2005-02-23 | 2012-08-31 | Genentech Inc | Extending time to disease progression or survival in cancer patients using a HER dimerization inhibitor |
| JP2008531560A (ja) * | 2005-02-23 | 2008-08-14 | アルザ・コーポレーシヨン | 中枢神経系への有効成分の鼻内投与 |
| US20090136505A1 (en) * | 2005-02-23 | 2009-05-28 | Johanna Bentz | Intranasal Administration of Active Agents to the Central Nervous System |
| TW200714289A (en) * | 2005-02-28 | 2007-04-16 | Genentech Inc | Treatment of bone disorders |
| SI1865986T1 (sl) | 2005-03-08 | 2016-05-31 | Pfizer Products Inc. | Sestavki protitelesa proti CTLA-4 |
| WO2006096861A2 (en) * | 2005-03-08 | 2006-09-14 | Genentech, Inc. | METHODS FOR IDENTIFYING TUMORS RESPONSIVE TO TREATMENT WITH HER DIMERIZATION INHIBITORS (HDIs) |
| WO2006099875A1 (en) | 2005-03-23 | 2006-09-28 | Genmab A/S | Antibodies against cd38 for treatment of multiple myeloma |
| EP3058955B1 (en) | 2005-03-24 | 2019-05-29 | Millennium Pharmaceuticals, Inc. | Antibodies that bind ov064 and methods of use therefor |
| EP1871911A2 (en) | 2005-04-07 | 2008-01-02 | Chiron Corporation | Cancer-related genes (prlr) |
| AU2006235276A1 (en) | 2005-04-07 | 2006-10-19 | Novartis Vaccines And Diagnostics Inc. | CACNA1E in cancer diagnosis, detection and treatment |
| ES2374419T3 (es) | 2005-04-11 | 2012-02-16 | National Research Council Of Canada | Identificación de una beta-1,3-n-acetilgalactosaminiltranferasa (cgte) de campylobacter jejuni lio87. |
| KR20080011403A (ko) | 2005-04-25 | 2008-02-04 | 화이자 인크. | 미오스타틴에 대한 항체 |
| AR054260A1 (es) * | 2005-04-26 | 2007-06-13 | Rinat Neuroscience Corp | Metodos de tratamiento de enfermedades de la neurona motora inferior y composiciones utilizadas en los mismos |
| KR100990027B1 (ko) | 2005-04-26 | 2010-10-26 | 화이자 인코포레이티드 | Ｐ-카드헤린 항체 |
| PE20061324A1 (es) | 2005-04-29 | 2007-01-15 | Centocor Inc | Anticuerpos anti-il-6, composiciones, metodos y usos |
| PE20061323A1 (es) * | 2005-04-29 | 2007-02-09 | Rinat Neuroscience Corp | Anticuerpos dirigidos contra el peptido amiloide beta y metodos que utilizan los mismos |
| ATE489624T1 (de) | 2005-04-29 | 2010-12-15 | Univ California | Antikörper gegen histonmodifikationen für die klinische krebsdiagnose und -prognose |
| KR101339628B1 (ko) | 2005-05-09 | 2013-12-09 | 메다렉스, 인코포레이티드 | 예정 사멸 인자 1(ｐｄ-1)에 대한 인간 모노클로날 항체, 및 항-ｐｄ-1 항체를 단독 사용하거나 기타 면역 요법제와 병용한 암 치료 방법 |
| NZ581779A (en) | 2005-05-17 | 2011-09-30 | Univ Connecticut | Composition and methods for immunomodulation in an organism comprising interleukin-15 polypeptide and interleukin-15 receptor subunit A polypeptide complex |
| EP1871163A2 (en) | 2005-06-06 | 2008-01-02 | Genentech, Inc. | Transgenic models for different genes and their use for gene characterization |
| EP1899376A2 (en) | 2005-06-16 | 2008-03-19 | The Feinstein Institute for Medical Research | Antibodies against hmgb1 and fragments thereof |
| US20070225242A1 (en) * | 2005-06-21 | 2007-09-27 | The Board Of Trustees Of The Leland Stanford Junior University | Method and composition for treating and preventing tumor metastasis in vivo |
| WO2007005955A2 (en) | 2005-06-30 | 2007-01-11 | Centocor, Inc. | Anti-il-23 antibodies, compositions, methods and uses |
| TW200741009A (en) | 2005-07-01 | 2007-11-01 | Oncotherapy Science Inc | Methods of modulating SMYD3 for treatment of cancer |
| KR101888321B1 (ko) | 2005-07-01 | 2018-08-13 | 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체 |
| WO2007008848A2 (en) | 2005-07-07 | 2007-01-18 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus |
| ES2708763T3 (es) | 2005-07-07 | 2019-04-11 | Seattle Genetics Inc | Compuestos de monometilvalina que tienen modificaciones de la cadena lateral de fenilalanina en el extremo C |
| US7482124B2 (en) * | 2005-07-08 | 2009-01-27 | Bristol-Myers Squibb Company | Method of identifying a PPARgamma-agonist compound having a decreased likelihood of inducing dose-dependent peripheral edema |
| WO2007011606A2 (en) * | 2005-07-18 | 2007-01-25 | Critical Therapeutics, Inc. | USE OF HMGBl ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY SKIN CONDITIONS |
| EP2397497A3 (en) | 2005-07-18 | 2013-11-27 | Amgen, Inc | Human anti-B7RP1 neutralizing antibodies |
| ES2438019T3 (es) * | 2005-07-22 | 2014-01-15 | Cytodyn, Inc. | Procedimientos para reducir la carga viral en pacientes infectados por el VIH-1 |
| WO2007014169A2 (en) * | 2005-07-22 | 2007-02-01 | Y's Therapeutics Co, Ltd. | Anti-cd26 antibodies and methods of use thereof |
| EP1907859B1 (en) | 2005-07-27 | 2011-03-02 | Oncotherapy Science, Inc. | Genes and polypeptides relating to prostate cancers |
| US20090317392A1 (en) | 2005-07-27 | 2009-12-24 | Yusuke Nakamura | Method of diagnosing small cell lung cancer |
| WO2007016240A2 (en) * | 2005-07-28 | 2007-02-08 | Novartis Ag | Use of antibody to m-csf |
| JP5457671B2 (ja) * | 2005-07-28 | 2014-04-02 | ノバルティス アーゲー | Ｍ−ｃｓｆ特異的モノクローナル抗体およびその使用 |
| WO2007016597A2 (en) * | 2005-07-29 | 2007-02-08 | The Regents Of The University Of California | Targeting tnf-alpha converting enzyme (tace)-dependent growth factor shedding in cancer therapy |
| WO2007117264A2 (en) * | 2005-08-03 | 2007-10-18 | Fraunhofer Usa, Inc. | Compositions and methods for production of immunoglobulins |
| EP1945257A4 (en) * | 2005-08-08 | 2009-05-06 | Onconon Llc | ANTIBODY COMPOSITIONS, METHODS OF TREATING NEOPLASTIC DISEASE, AND METHOD FOR REGULATING FERTILITY |
| AU2006279896A1 (en) * | 2005-08-10 | 2007-02-22 | Oklahoma Medical Research Foundation | Truncated memapsin 2 for use for treating Alzheimer's disease |
| CA2619577A1 (en) | 2005-08-15 | 2007-02-22 | Genentech, Inc. | Gene disruptions, compositions and methods relating thereto |
| CA2619695A1 (en) | 2005-08-18 | 2007-02-22 | Genmab A/S | Therapy with cd4 binding peptides and radiation |
| US20070202512A1 (en) * | 2005-08-19 | 2007-08-30 | Bristol-Myers Squibb Company | Human single nucleotide polymorphisms associated with dose-dependent weight gain and methods of use thereof |
| US20080234213A1 (en) * | 2005-09-02 | 2008-09-25 | Matthias Wabl | Oncogenic regulatory RNAs for diagnostics and therapeutics |
| US7537762B2 (en) | 2005-09-07 | 2009-05-26 | Amgen Fremont, Inc. | Human monoclonal antibodies to activin receptor-like kinase-1 |
| AR057807A1 (es) * | 2005-09-12 | 2007-12-19 | Novimmune Sa | Formulaciones de anticuerpo anti-cd3 |
| JP2009509510A (ja) | 2005-09-26 | 2009-03-12 | メダレックス インコーポレーティッド | Ｃｄ７０に対するヒトモノクローナル抗体 |
| IL172297A (en) | 2005-10-03 | 2016-03-31 | Compugen Ltd | Soluble vegfr-1 variants for the diagnosis of preeclampsia |
| US20070118914A1 (en) * | 2005-10-06 | 2007-05-24 | Baylor Research Institute | Oncohumouse |
| GB0520568D0 (en) | 2005-10-10 | 2005-11-16 | Paradigm Therapeutics Ltd | Receptor |
| EP1973928A2 (en) * | 2005-10-11 | 2008-10-01 | Ramot at Tel-Aviv University Ltd. | Self-assembled fmoc-ff hydrogels |
| UA92504C2 (en) | 2005-10-12 | 2010-11-10 | Эли Лилли Энд Компани | Anti-myostatin monoclonal antibody |
| CN103435695A (zh) * | 2005-10-21 | 2013-12-11 | Gtc生物治疗有限公司 | 具有增强的抗体依赖性细胞毒性活性的抗体及其生产方法和用途 |
| NZ568385A (en) | 2005-10-21 | 2012-07-27 | Univ California | C-kit oncogene mutations in melanoma |
| EP2532679B1 (en) | 2005-10-21 | 2017-04-12 | Novartis AG | Human antibodies against il13 and therapeutic uses |
| LT2848258T (lt) | 2005-10-26 | 2018-02-26 | Novartis Ag | Šeiminės viduržemio jūros karštligės gydymas su anti-il-1 beta antikūnais |
| EP1961065A4 (en) | 2005-10-31 | 2009-11-11 | Oncomed Pharm Inc | COMPOSITIONS AND METHOD FOR DIAGNOSIS AND TREATMENT OF CANCER |
| US20070099246A1 (en) * | 2005-11-03 | 2007-05-03 | Sandy John D | Antibodies, assays and kits to quantitate cartilage destruction |
| US7879212B2 (en) * | 2005-11-03 | 2011-02-01 | Ramot At Tel-Aviv University Ltd. | Peptide nanostructure-coated electrodes |
| AU2006315580A1 (en) | 2005-11-10 | 2007-05-24 | Curagen Corporation | Method of treating ovarian and renal cancer using antibodies against T cell immunoglobulin domain and mucin domain 1 (TIM-1) antigen |
| DK1957106T4 (da) | 2005-11-14 | 2019-10-28 | Teva Pharmaceuticals Int Gmbh | Antagonist-antistoffer, der er rettet mod calcitonin-gen-relateret peptid og fremgangsmåder til anvendelse af disse |
| MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
| CA2630432A1 (en) | 2005-11-21 | 2007-07-19 | Genentech, Inc. | Novel gene disruptions, compositions and methods relating thereto |
| US8846393B2 (en) | 2005-11-29 | 2014-09-30 | Gamida-Cell Ltd. | Methods of improving stem cell homing and engraftment |
| RU2426742C2 (ru) | 2005-12-02 | 2011-08-20 | Дженентек, Инк. | Составы и способы лечения заболеваний и нарушений, связанных с передачей сигналов цитокинами |
| WO2007065027A2 (en) | 2005-12-02 | 2007-06-07 | Dana Farber Cancer Institute | Carbonic anhydrase ix (g250) antibodies and methods of use thereof |
| WO2007067959A2 (en) | 2005-12-07 | 2007-06-14 | Medarex, Inc. | Ctla-4 antibody dosage escalation regimens |
| KR101446510B1 (ko) | 2005-12-08 | 2014-10-20 | 메다렉스, 엘.엘.시. | 푸코실-지엠1에 대한 인간 모노클론 항체 및 항-푸코실-지엠1 사용법 |
| KR101422523B1 (ko) | 2005-12-09 | 2014-07-24 | 유씨비 파마, 에스.에이. | 사람 ｉｌ6에 특이성을 지니는 항체 분자 |
| DK1963368T6 (da) | 2005-12-13 | 2020-06-29 | Lilly Co Eli | Anti-il-17-antistoffer |
| CA2633956C (en) | 2005-12-13 | 2016-12-06 | Olivia Raeber | Binding proteins specific for insulin-like growth factors and uses thereof |
| JP5236488B2 (ja) | 2005-12-14 | 2013-07-17 | ハーモ ファーマ エルテーデー． | 新規な神経栄養因子タンパク質およびその用途 |
| AR057237A1 (es) | 2005-12-15 | 2007-11-21 | Genentech Inc | Metodos y composiciones para actuar sobre la poliubiquitina |
| US7625759B2 (en) | 2005-12-19 | 2009-12-01 | Genentech, Inc. | Method for using BOC/CDO to modulate hedgehog signaling |
| WO2007073567A2 (en) * | 2005-12-22 | 2007-06-28 | Iq Corporation | Compositions and methods of modulating the immune response |
| AR056857A1 (es) | 2005-12-30 | 2007-10-24 | U3 Pharma Ag | Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos |
| EP2463305B1 (en) | 2006-01-12 | 2016-05-11 | Alexion Pharmaceuticals, Inc. | Antibodies to OX-2/CD200 and uses thereof |
| EP1973945A4 (en) | 2006-01-16 | 2009-11-18 | Compugen Ltd | NEW NUCLEOTIDE AND AMINO ACID SEQUENCES AND METHOD FOR THEIR APPLICATION IN DIAGNOSIS |
| US20070166306A1 (en) * | 2006-01-17 | 2007-07-19 | Fey Georg H M | Anti-CD19 antibody composition and method |
| WO2007084672A2 (en) | 2006-01-17 | 2007-07-26 | Medarex, Inc. | Monoclonal antibodies against cd30 lacking in fucosyl and xylosyl residues |
| US20070178103A1 (en) * | 2006-01-30 | 2007-08-02 | Fey Georg H | CD19-specific immunotoxin and treatment method |
| US7803561B2 (en) * | 2006-02-06 | 2010-09-28 | Rhode Island Hospital | GPR30 estrogen receptor in breast cancers |
| US7790857B2 (en) * | 2006-02-10 | 2010-09-07 | Sanofi Pasteur Limited | Monoclonal antibodies and uses thereof |
| WO2007092023A1 (en) * | 2006-02-11 | 2007-08-16 | Boston Biomedical Research Institute | Compositions and methods for binding or inactivating ghrelin |
| US8277816B2 (en) * | 2006-02-13 | 2012-10-02 | Fraunhofer Usa, Inc. | Bacillus anthracis antigens, vaccine compositions, and related methods |
| CA2642056A1 (en) * | 2006-02-13 | 2007-08-23 | Fraunhofer Usa, Inc. | Hpv antigens, vaccine compositions, and related methods |
| KR20080106433A (ko) * | 2006-02-13 | 2008-12-05 | 프라운호퍼 유에스에이, 인코포레이티드 | 인플루엔자 항원, 백신 조성물 및 관련 방법 |
| CA2638821A1 (en) | 2006-02-17 | 2007-10-11 | Genentech, Inc. | Gene disruptons, compositions and methods relating thereto |
| US20080317710A1 (en) | 2006-02-22 | 2008-12-25 | University Of Zurich | Methods For Treating Autoimmune or Demyelinating Diseases |
| US7459280B2 (en) * | 2006-02-27 | 2008-12-02 | Picobella, Llc | Methods for diagnosing and treating kidney cancer |
| JP2009529915A (ja) | 2006-03-20 | 2009-08-27 | ゾーマ テクノロジー リミテッド | ガストリン物質に対して特異的なヒト抗体および方法 |
| WO2007109347A2 (en) | 2006-03-21 | 2007-09-27 | The Regents Of The University Of California | N-cadherin and ly6 e: targets for cancer diagnosis and therapy |
| NZ615012A (en) | 2006-03-21 | 2015-11-27 | Genentech Inc | Combinatorial therapy involving alpha5beta1 antagonists |
| US20100278821A1 (en) | 2006-03-21 | 2010-11-04 | The Regents Of The University Of California | N-cadherin: target for cancer diagnosis and therapy |
| SG170728A1 (en) | 2006-03-23 | 2011-05-30 | Novartis Ag | Anti-tumor cell antigen antibody therapeutics |
| JP5514539B2 (ja) | 2006-03-31 | 2014-06-04 | メダレックス・リミテッド・ライアビリティ・カンパニー | ヒト抗体の調製に用いるためのキメラ抗体を発現するトランスジェニック動物 |
| US8221966B2 (en) | 2006-03-31 | 2012-07-17 | Dana Farber Cancer Institute | Methods of determining cellular chemosensitivity |
| CA2647277A1 (en) | 2006-04-05 | 2007-11-08 | Genentech, Inc. | Method for using boc/cdo to modulate hedgehog signaling |
| DK2371865T3 (en) | 2006-04-07 | 2017-10-23 | Aerpio Therapeutics Inc | Antibodies that bind human protein tyrosine phosphatase beta (HPTP-β) and uses thereof |
| US8524454B2 (en) * | 2006-04-07 | 2013-09-03 | The Research Foundation Of State University Of New York | Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency |
| EP2010567A2 (en) * | 2006-04-07 | 2009-01-07 | The Government of the United States of America as Represented by The Department of Health and Human Services | Antibody compositions and methods for treatment of neoplastic disease |
| US9044461B2 (en) | 2006-04-07 | 2015-06-02 | The Research Foundation Of State University Of New York | Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency |
| TW200813091A (en) | 2006-04-10 | 2008-03-16 | Amgen Fremont Inc | Targeted binding agents directed to uPAR and uses thereof |
| AU2007238636A1 (en) | 2006-04-13 | 2007-10-25 | Novartis Vaccines & Diagnostics, Inc. | Methods of treating, diagnosing or detecting cancer |
| AU2007238677B2 (en) | 2006-04-14 | 2011-03-10 | Novartis Ag | Use of IL-I antibodies for treating ophthalmic disorders |
| EP2082645A1 (en) | 2006-04-19 | 2009-07-29 | Genentech, Inc. | Novel gene disruptions, compositions and methods relating thereto |
| AU2007240614B2 (en) | 2006-04-20 | 2013-09-12 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine Incorporated | Methods and compositions based on Shiga toxin type 1 protein |
| US7727525B2 (en) * | 2006-05-11 | 2010-06-01 | City Of Hope | Engineered anti-CD20 antibody fragments for in vivo targeting and therapeutics |
| US20090142259A1 (en) * | 2006-05-12 | 2009-06-04 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of bladder and urinary tract tumors |
| CN103435697A (zh) | 2006-05-15 | 2013-12-11 | 航道生物技术有限责任公司 | 流感病毒的中和抗体 |
| WO2007137163A2 (en) | 2006-05-19 | 2007-11-29 | Georgia Tech Research Corporation | Abc transporter ligand |
| SG10201501103RA (en) | 2006-05-30 | 2015-04-29 | Genentech Inc | Antibodies And Immunoconjugates And Uses Therefor |
| US7862812B2 (en) | 2006-05-31 | 2011-01-04 | Lpath, Inc. | Methods for decreasing immune response and treating immune conditions |
| EP2374818B1 (en) | 2006-06-02 | 2012-12-19 | Regeneron Pharmaceuticals, Inc. | High affinity antibodies to human IL-6 receptor |
| AU2007319672B2 (en) * | 2006-06-06 | 2011-06-30 | Genentech, Inc. | Anti-DLL4 antibodies and methods using same |
| CA2654304A1 (en) * | 2006-06-06 | 2007-12-13 | Genentech, Inc. | Compositions and methods for modulating vascular development |
| KR101510753B1 (ko) | 2006-06-07 | 2015-04-10 | 바이오얼라이언스 씨.브이. | 암세포 상에서 발현되는 ｃｄ-43 및 ｃｅａ 상의 에피토프를 함유하는 탄수화물을 인식하는 항체 및 이를 이용하는 방법 |
| WO2007147122A2 (en) | 2006-06-15 | 2007-12-21 | The Board Of Trustees Of The University Of Arkansas | Monoclonal antibodies that selectively recognize methamphetamine and methamphetamine like compounds |
| US8874380B2 (en) | 2010-12-09 | 2014-10-28 | Rutgers, The State University Of New Jersey | Method of overcoming therapeutic limitations of nonuniform distribution of radiopharmaceuticals and chemotherapy drugs |
| US7572618B2 (en) | 2006-06-30 | 2009-08-11 | Bristol-Myers Squibb Company | Polynucleotides encoding novel PCSK9 variants |
| EP2037737B1 (en) | 2006-07-11 | 2014-04-02 | University Of Medicine And Dentistry Of New Jersey | Cell membrane repair proteins, nucleic acids encoding the same and associated methods of use |
| US8324158B2 (en) | 2006-07-14 | 2012-12-04 | Georgia Tech Research Corporation | Methods for inhibiting CLC-2 channel with GATX2 |
| AU2007275654A1 (en) | 2006-07-19 | 2008-01-24 | The Trustees Of The University Of Pennsylvania | WSX-1/p28 as a target for anti-inflammatory responses |
| CL2007002225A1 (es) | 2006-08-03 | 2008-04-18 | Astrazeneca Ab | Agente de union especifico para un receptor del factor de crecimiento derivado de plaquetas (pdgfr-alfa); molecula de acido nucleico que lo codifica; vector y celula huesped que la comprenden; conjugado que comprende al agente; y uso del agente de un |
| TW200815474A (en) | 2006-08-03 | 2008-04-01 | Astrazeneca Ab | Antibodies alphaVbeta6 and uses thereof |
| WO2008019326A2 (en) | 2006-08-04 | 2008-02-14 | Novartis Ag | Ephb3-specific antibody and uses thereof |
| AU2007281774A1 (en) | 2006-08-04 | 2008-02-14 | Astrazeneca Ab | Human antibodies to ErbB 2 |
| EP2057465A4 (en) | 2006-08-09 | 2010-04-21 | Homestead Clinical Corp | SPECIFIC ORGAN PROTEINS AND METHODS OF USE |
| EP2423231A3 (en) | 2006-08-18 | 2012-05-30 | Novartis AG | PRLR-specific antibody and uses thereof |
| ZA200900954B (en) | 2006-08-22 | 2010-05-26 | G2 Inflammation Pty Ltd | Ant-C5aR antibodies with improved properties |
| EP2423333A1 (en) | 2006-08-25 | 2012-02-29 | Oncotherapy Science, Inc. | Prognostic markers and therapeutic targets for lung cancer |
| PL2059533T3 (pl) | 2006-08-30 | 2013-04-30 | Genentech Inc | Przeciwciała wieloswoiste |
| US8636995B2 (en) * | 2006-08-31 | 2014-01-28 | Cardiac Pacemakers, Inc. | Methods and devices to regulate stem cell homing |
| US20080058922A1 (en) * | 2006-08-31 | 2008-03-06 | Cardiac Pacemakers, Inc. | Methods and devices employing vap-1 inhibitors |
| US8372399B2 (en) * | 2006-08-31 | 2013-02-12 | Cardiac Pacemakers, Inc. | Bispecific antibodies and agents to enhance stem cell homing |
| CN101506235B (zh) | 2006-09-01 | 2012-07-25 | 人类多细胞株治疗学公司 | 人或人源化免疫球蛋白在非人转基因动物中增强的表达 |
| US20090053210A1 (en) * | 2006-09-01 | 2009-02-26 | Roland Buelow | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| AU2007292890A1 (en) | 2006-09-05 | 2008-03-13 | Medarex, Inc. | Antibodies to bone morphogenic proteins and receptors therefor and methods for their use |
| CA2662236A1 (en) | 2006-09-12 | 2008-03-20 | Genentech, Inc. | Methods and compositions for the diagnosis and treatment of cancer |
| US7884180B2 (en) | 2006-09-18 | 2011-02-08 | Compugen Ltd | Peptides which bind to G protein-coupled receptors |
| US20080076139A1 (en) | 2006-09-21 | 2008-03-27 | Sharat Singh | Methods and compositions for detecting the activation states of multiple signal transducers in rare circulating cells |
| WO2008094316A2 (en) | 2006-09-22 | 2008-08-07 | Stowers Institute Of Medical Research | Novel branchiostoma derived fluorescent proteins |
| RS59005B1 (sr) | 2006-09-26 | 2019-08-30 | Genmab As | Anti-cd38 plus kortikosteroidi plus nekortikosteroidni hemoterapeutik za tretiranje tumora |
| JP2010504955A (ja) * | 2006-09-28 | 2010-02-18 | メルク セローノ ソシエテ アノニム | 接合部接着分子ｃ（ｊａｍ−ｃ）結合化合物とその利用方法 |
| ES2557953T3 (es) | 2006-09-29 | 2016-01-29 | Oncomed Pharmaceuticals, Inc. | Composiciones y métodos para diagnosticar y tratar cáncer |
| CA2664343C (en) | 2006-10-02 | 2016-04-26 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human il-4 receptor |
| ES2553553T3 (es) | 2006-10-02 | 2015-12-10 | E. R. Squibb & Sons, L.L.C. | Anticuerpos humanos que se unen a CXCR4 y usos de los mismos |
| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| US9505821B2 (en) | 2006-10-03 | 2016-11-29 | Rutgers, The State University Of New Jersey | ATAP peptides, nucleic acids encoding the same and associated methods of use |
| WO2008043018A1 (en) | 2006-10-04 | 2008-04-10 | Dana-Farber Cancer Institute, Inc. | Tumor immunity |
| JP5298021B2 (ja) * | 2006-10-12 | 2013-09-25 | ジェネンテック， インコーポレイテッド | リンホトキシン−αに対する抗体 |
| DK2068922T3 (da) | 2006-10-19 | 2012-10-08 | Csl Ltd | Anti-IL-13Ralfa1-antistoffer samt deres anvendelser |
| RU2460541C2 (ru) | 2006-10-27 | 2012-09-10 | Лпат, Инк. | Композиции и способы связывания сфингозин-1-фосфата |
| WO2008055072A2 (en) | 2006-10-27 | 2008-05-08 | Lpath, Inc. | Compositions and methods for treating ocular diseases and conditions |
| ES2636089T3 (es) | 2006-10-27 | 2017-10-05 | Genentech, Inc. | Anticuerpos e inmunoconjugados y usos para los mismos |
| US9457047B2 (en) | 2006-11-06 | 2016-10-04 | Whitehead Institute | Immunomodulating compositions and methods of use thereof |
| ES2397186T3 (es) * | 2006-11-06 | 2013-03-05 | Whitehead Institute | Composiciones inmunomoduladoras y métodos para su uso |
| WO2008076560A2 (en) | 2006-11-15 | 2008-06-26 | Medarex, Inc. | Human monoclonal antibodies to btla and methods of use |
| WO2008140586A2 (en) | 2006-11-21 | 2008-11-20 | The Regents Of The University Of California | Modulation of rhamm (cd168) for selective adipose tissue development |
| US20100062000A1 (en) * | 2006-11-21 | 2010-03-11 | The Regents Of The University Of California | Rhamm, a Co-Receptor and Its Interactions with Other Receptors in Cancer Cell Motility and the Identification of Cancer Prognitor Cell Populations |
| EP2101780B1 (en) | 2006-11-21 | 2013-10-09 | Kalobios Pharmaceuticals, Inc. | Methods of treating chronic inflammatory diseases using a gm-csf antagonist |
| EP2962697A1 (en) | 2006-11-27 | 2016-01-06 | diaDexus, Inc. | Ovr110 antibody compositions and methods of use |
| TWI447124B (zh) | 2006-12-01 | 2014-08-01 | Medarex Llc | 結合ｃｄ２２的人類抗體與其應用 |
| CA2672120A1 (en) | 2006-12-07 | 2008-06-12 | Novartis Ag | Antagonistic antibodies against ephb3 |
| CL2007003622A1 (es) | 2006-12-13 | 2009-08-07 | Medarex Inc | Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales. |
| IN2009KN02404A (ja) | 2006-12-14 | 2015-08-07 | Medarex Inc | |
| RU2448979C2 (ru) | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Антитела человека к дельта-подобному лиганду-4 человека |
| DK2101807T3 (en) | 2006-12-19 | 2016-08-29 | Genentech Inc | VEGF-SPECIFIC ANTAGONISTS FOR ADMINISTRATIVE AND NEOADVERTIVE TREATMENT AND TREATMENT OF TEMPERATURES IN EARLY STAGE |
| US20090186034A1 (en) * | 2006-12-19 | 2009-07-23 | Genetech, Inc. | Gene expression markers for inflammatory bowel disease |
| RU2554747C9 (ru) | 2006-12-20 | 2015-10-20 | Ксома (Сша) Ллс | Способы лечения il-1бета-зависимых заболеваний |
| WO2008094370A2 (en) | 2006-12-22 | 2008-08-07 | University Of Utah Research Foundation | Method of detecting ocular diseases and pathologic conditions and treatment of same |
| WO2008079322A1 (en) * | 2006-12-22 | 2008-07-03 | Beckman Coulter, Inc. | Methods, kits and materials for diagnosing disease states by measuring isoforms or proforms of myeloperoxidase |
| WO2008088823A2 (en) * | 2007-01-16 | 2008-07-24 | Abbott Laboratories | Methods for treating psoriasis |
| US8148147B2 (en) * | 2007-01-24 | 2012-04-03 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
| WO2008091222A1 (en) * | 2007-01-26 | 2008-07-31 | Bioinvent International Ab | Dll4 signaling inhibitors and uses thereof |
| EP2111412A2 (en) * | 2007-02-02 | 2009-10-28 | Amgen, Inc | Hepcidin and hepcidin antibodies |
| US7834154B2 (en) | 2007-02-09 | 2010-11-16 | Genentech, Inc. | Anti-ROBO4 antibodies and uses therefor |
| DK2129396T3 (da) | 2007-02-16 | 2013-11-25 | Merrimack Pharmaceuticals Inc | Antistoffer mod ErbB3 og anvendelser deraf |
| ES2456961T3 (es) | 2007-02-21 | 2014-04-24 | University Of Massachusetts | Anticuerpos humanos contra el virus de la hepatitis C (VHC), usos de los mismos |
| AU2008218199B2 (en) | 2007-02-22 | 2013-10-31 | Genentech, Inc. | Methods for detecting inflammatory bowel disease |
| ES2662036T3 (es) | 2007-02-28 | 2018-04-05 | Yeda Research And Development Company Limited | Secuencias que se dirigen al núcleo |
| MX2009008981A (es) | 2007-03-02 | 2009-09-02 | Genentech Inc | Prediccion de respuesta a un inhibidor her. |
| EP3199180B1 (en) | 2007-03-08 | 2022-01-05 | Humanigen, Inc. | Epha3 antibodies for the treatment of solid tumors |
| EP2125898B1 (en) | 2007-03-14 | 2013-05-15 | Novartis AG | Apcdd1 inhibitors for treating, diagnosing or detecting cancer |
| BRPI0809042B1 (pt) | 2007-03-22 | 2021-08-31 | Biogen Ma Inc. | Proteína de ligação a cd154 isolada, seu uso, e composição |
| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| WO2008116347A1 (en) | 2007-03-26 | 2008-10-02 | General Regeneratives Limited | Methods for promoting protection and regeneration of bone marrow using cxcl9 and anti-cxcl9 antibodies |
| CN101802015B (zh) | 2007-03-29 | 2015-05-06 | 根马布股份公司 | 双特异性抗体及其制造方法 |
| EP2144935A2 (en) | 2007-03-29 | 2010-01-20 | Technion Research & Development Foundation Ltd. | Antibodies, methods and kits for diagnosing and treating melanoma |
| AU2008239633B2 (en) | 2007-04-12 | 2014-05-29 | The Brigham And Women's Hospital, Inc. | Targeting ABCB5 for cancer therapy |
| ES2619647T3 (es) * | 2007-04-20 | 2017-06-26 | Bioventures Llc | Compuestos de hapteno y composiciones y usos de los mismos |
| FI20075278A0 (fi) | 2007-04-20 | 2007-04-20 | Biotie Therapies Corp | Uudet täysin ihmisperäiset anti-VAP-1 monoklonaaliset vasta-aineet |
| US20080267977A1 (en) * | 2007-04-26 | 2008-10-30 | Friedrich-Alexander University Of Erlangen-Nuremberg | Combined immunological agent and sensitizing agent for the treatment of cancer |
| BRPI0810865A2 (pt) * | 2007-04-28 | 2017-05-09 | Fraunhofer Usa Inc | antígenos de tripanossoma, composições vacinais, e métodos relacionados |
| KR101729431B1 (ko) | 2007-05-21 | 2017-04-21 | 제넨테크, 인크. | 루푸스를 확인 및 치료하기 위한 방법 및 조성물 |
| KR20180032687A (ko) | 2007-05-29 | 2018-03-30 | 노파르티스 아게 | 항-ｉｌ-1-베타 치료법에 대한 신규 적응증 |
| JP5989299B2 (ja) * | 2007-05-30 | 2016-09-07 | エルパス・インコーポレイテッドＬｐａｔｈ， Ｉｎｃ． | リゾホスファチジン酸結合のための組成物と方法 |
| US9163091B2 (en) * | 2007-05-30 | 2015-10-20 | Lpath, Inc. | Compositions and methods for binding lysophosphatidic acid |
| US20110064744A1 (en) * | 2007-05-30 | 2011-03-17 | Sabbadini Roger A | Prevention and treatment of pain using antibodies to lysophosphatidic acid |
| EP4119579A1 (en) | 2007-05-31 | 2023-01-18 | Genmab A/S | Stable igg4 antibodies |
| CA2689695A1 (en) | 2007-05-31 | 2008-12-04 | Genmab A/S | Transgenic animals producing monovalent human antibodies and antibodies obtainable from these animals |
| US8703485B2 (en) | 2007-06-01 | 2014-04-22 | Omt, Inc. | Germ cells having inactivated endogenous immunoglobulin genes, and transgenic animals derived therefrom |
| CN103694351A (zh) | 2007-06-05 | 2014-04-02 | 耶鲁大学 | 受体酪氨酸激酶抑制剂及其使用方法 |
| SI2171090T1 (sl) | 2007-06-08 | 2013-07-31 | Genentech, Inc. | Markerji genskega izraĹľanja tumorske odpornosti na HER2 inhibitorsko zdravljenje |
| TWI478939B (zh) | 2007-06-15 | 2015-04-01 | Deutsches Krebsforsch | 使用特定抗－ｌ１抗體治療腫瘤 |
| US20080317768A1 (en) | 2007-06-21 | 2008-12-25 | Boeing Company | Bioconjugated nanoparticles |
| CA2691378A1 (en) | 2007-07-02 | 2009-01-08 | Oncomed Pharmaceuticals, Inc. | Antibody against human r-spondin (rspo) and use thereof for inhibition of beta-catenin signaling and treatment of cancer |
| MX354993B (es) | 2007-07-09 | 2018-03-28 | Genentech Inc | Prevención de reducción de enlaces de disulfuro durante la producción recombinante de polipéptidos. |
| CA2692933C (en) | 2007-07-11 | 2016-10-18 | Fraunhofer Usa, Inc. | Yersinia pestis antigens, vaccine compositions, and related methods |
| WO2009007848A2 (en) | 2007-07-12 | 2009-01-15 | Compugen Ltd. | Bioactive peptides and method of using same |
| WO2009010968A2 (en) | 2007-07-15 | 2009-01-22 | Yitzchak Hillman | Disease treatment via antimicrobial peptides or their inhibitors |
| IL184627A0 (en) | 2007-07-15 | 2008-12-29 | Technion Res & Dev Foundation | Agents for diagnosing and modulating metastasis and fibrosis as well as inflammation in a mammalian tissue |
| AR067544A1 (es) | 2007-07-16 | 2009-10-14 | Genentech Inc | Anticuerpos anti- cd79b e inmunoconjugados y metodos de uso de los mismos |
| EP2641618A3 (en) | 2007-07-16 | 2013-10-23 | Genentech, Inc. | Humanized anti-CD79B antibodies and immunoconjugates and methods of use |
| SI2182981T1 (sl) * | 2007-08-02 | 2013-05-31 | Gilead Biologics, Inc. | Postopki in sestavki za zdravljenje in diagnozo fibroze |
| AU2008317495B2 (en) | 2007-08-02 | 2013-08-01 | Novimmune S.A. | Anti-RANTES antibodies and methods of use thereof |
| US20090035216A1 (en) * | 2007-08-03 | 2009-02-05 | Biomonitor Aps | Method for determining in vivo biopharmaceutical concentration or bioavailability |
| WO2009097006A2 (en) | 2007-08-10 | 2009-08-06 | Medarex, Inc. | Hco32 and hco27 and related examples |
| AU2008287427B2 (en) | 2007-08-13 | 2014-10-09 | Vasgene Therapeutics, Inc. | Cancer treatment using humanized antibodies that bind to EphB4 |
| ES2477294T3 (es) | 2007-08-13 | 2014-07-16 | Baxter International Inc | Modulación por IVIG de quimioquinas para el tratamiento de la esclerosis múltiple, la enfermedad de Alzheimer y la enfermedad de Parkinson |
| CN102083455B (zh) | 2007-08-15 | 2015-01-07 | 耶达研究及发展有限公司 | Mmp-9的调节剂及其用途 |
| RU2486195C2 (ru) | 2007-08-20 | 2013-06-27 | Онкотерапи Сайенс, Инк. | Пептид cdca1 и включающее его фармацевтическое средство |
| WO2009026397A2 (en) * | 2007-08-20 | 2009-02-26 | Fraunhofer Usa, Inc. | Prophylactic and therapeutic influenza vaccines, antigens, compositions, and methods |
| ES2632123T3 (es) | 2007-08-20 | 2017-09-11 | Oncotherapy Science, Inc. | Péptido CDH3 y agente medicinal que comprende el mismo |
| US8569244B2 (en) | 2007-08-20 | 2013-10-29 | Oncotherapy Science, Inc. | FOXM1 peptide and medicinal agent comprising the same |
| TWI595005B (zh) | 2007-08-21 | 2017-08-11 | 安健股份有限公司 | 人類ｃ－ｆｍｓ抗原結合蛋白質 |
| US8865875B2 (en) | 2007-08-22 | 2014-10-21 | Medarex, L.L.C. | Site-specific attachment of drugs or other agents to engineered antibodies with C-terminal extensions |
| EP2615113A3 (en) | 2007-08-23 | 2013-11-13 | Amgen Inc. | Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) |
| JOP20080381B1 (ar) | 2007-08-23 | 2023-03-28 | Amgen Inc | بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9) |
| KR20100075857A (ko) | 2007-08-24 | 2010-07-05 | 온코세라피 사이언스 가부시키가이샤 | 폐암의 치료 및 진단의 표적유전자인 ｅｂｉ３，ｄｌｘ５，ｎｐｔｘ１ 및 ｃｄｋｎ |
| DK2769729T3 (en) | 2007-09-04 | 2019-04-23 | Compugen Ltd | POLYPEPTIDES AND POLYNUCLEOTIDES AND APPLICATIONS THEREOF AS A PHARMACEUTICAL OBJECTIVE FOR THE PRODUCTION OF MEDICINAL PRODUCTS AND BIOTECHNOLOGICAL PRODUCTS |
| TW200918553A (en) | 2007-09-18 | 2009-05-01 | Amgen Inc | Human GM-CSF antigen binding proteins |
| JP5685442B2 (ja) | 2007-09-26 | 2015-03-18 | ウー３・フアルマ・ゲー・エム・ベー・ハーＵ３ Ｐｈａｒｍａ | ヘパリン結合上皮成長因子様成長因子抗原結合タンパク質 |
| CN104004088B (zh) | 2007-09-26 | 2017-11-07 | Ucb医药有限公司 | 双特异性抗体融合物 |
| TWI489993B (zh) | 2007-10-12 | 2015-07-01 | Novartis Ag | 骨硬化素（ｓｃｌｅｒｏｓｔｉｎ）抗體組合物及使用方法 |
| HUE030134T2 (en) | 2007-10-16 | 2017-04-28 | Zymogenetics Inc | Combination of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) and anti-CD20 agents for the treatment of autoimmune diseases |
| US8361465B2 (en) * | 2007-10-26 | 2013-01-29 | Lpath, Inc. | Use of anti-sphingosine-1-phosphate antibodies in combination with chemotherapeutic agents |
| WO2009059305A2 (en) | 2007-11-01 | 2009-05-07 | The University Of Chicago | Red fluorescent proteins with enhanced bacterial expression, increased brightness and reduced aggregation |
| DK2567709T3 (en) | 2007-11-02 | 2018-03-12 | Novartis Ag | Molecules and Methods for Modulating Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) |
| SI2514436T1 (en) | 2007-11-07 | 2018-04-30 | Genentech, Inc. | IL-22 for use in the treatment of microbial diseases |
| AU2008323848B2 (en) * | 2007-11-07 | 2014-09-25 | Celldex Therapeutics Inc. | Antibodies that bind human dendritic and epithelial cell 205 (DEC-205) |
| MX2010005080A (es) | 2007-11-07 | 2010-07-28 | Genentech Inc | Metodos y composiciones para determinar la sensibilidad de linfoma de celula b al tratamiento con anticuerpos anti-cd40. |
| JP5809415B2 (ja) | 2007-11-09 | 2015-11-10 | ペレグリン ファーマシューティカルズ，インコーポレーテッド | 抗ｖｅｇｆ抗体の組成物および方法 |
| CA2705555A1 (en) | 2007-11-12 | 2009-05-22 | Theraclone Sciences, Inc. | Compositions and methods for the therapy and diagnosis of influenza |
| US20110033476A1 (en) * | 2007-11-12 | 2011-02-10 | Theraclone Sciences Inc. | Compositions and methods for the therapy and diagnosis of influenza |
| BRPI0820073A2 (pt) | 2007-11-12 | 2015-06-23 | U3 Pharma Gmbh | Anticorpos anti-axl |
| WO2009064944A2 (en) | 2007-11-16 | 2009-05-22 | Nuvelo, Inc. | Antibodies to lrp6 |
| CN101970689A (zh) | 2007-11-29 | 2011-02-09 | 健泰科生物技术公司 | 炎性肠病的基因表达标志物 |
| TWI580694B (zh) | 2007-11-30 | 2017-05-01 | 建南德克公司 | 抗-ｖｅｇｆ抗體 |
| US8815237B2 (en) | 2007-12-05 | 2014-08-26 | Massachusetts Institute Of Technology | Aglycosylated immunoglobulin mutants |
| RU2010127156A (ru) | 2007-12-06 | 2012-01-20 | Дана-Фарбер Кэнсер Инститьют, Инк. (Us) | Антитела против вируса гриппа и их применение |
| JP5591712B2 (ja) | 2007-12-14 | 2014-09-17 | ノボ・ノルデイスク・エー／エス | ヒトｎｋｇ２ｄに対する抗体とその使用 |
| ES2526887T3 (es) | 2007-12-14 | 2015-01-16 | Bristol-Myers Squibb Company | Método para producir moléculas de unión al receptor OX40 humano |
| KR101499278B1 (ko) | 2007-12-17 | 2015-03-06 | 화이자 리미티드 | 간질성 방광염의 치료 |
| CA2706502C (en) | 2007-12-18 | 2018-08-07 | Bioalliance C.V. | Antibodies recognizing a carbohydrate containing epitope on cd-43 and cea expressed on cancer cells and methods using same |
| EP2391650B1 (en) | 2007-12-20 | 2014-10-15 | Xoma (Us) Llc | Methods for the treatment of gout |
| EP2261254A3 (en) | 2007-12-21 | 2011-04-13 | Amgen, Inc | Anti-amyloid antibodies and uses thereof |
| EP2238167B1 (en) | 2007-12-27 | 2015-04-22 | Abbott Laboratories | Anti-t. cruzi antibodies and methods of use |
| US8962806B2 (en) | 2007-12-28 | 2015-02-24 | Dana-Farber Cancer Institute, Inc. | Humanized monoclonal antibodies and methods of use |
| US20090226914A1 (en) * | 2007-12-31 | 2009-09-10 | Bates Paula J | Methods and products to target, capture and characterize stem cells |
| US7914785B2 (en) | 2008-01-02 | 2011-03-29 | Bergen Teknologieverforing As | B-cell depleting agents, like anti-CD20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome |
| EP2077281A1 (en) | 2008-01-02 | 2009-07-08 | Bergen Teknologioverforing AS | Anti-CD20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome |
| GB0800277D0 (en) | 2008-01-08 | 2008-02-13 | Imagination Tech Ltd | Video motion compensation |
| EP3181588A1 (en) | 2008-01-11 | 2017-06-21 | Adheron Therapeutics, Inc. | Cadherin-11 antagonists and methods for the treatment of inflammatory joint disorders |
| US8575107B2 (en) * | 2008-01-22 | 2013-11-05 | Compugen Ltd. | Clusterin derived peptide |
| MX2010008096A (es) | 2008-01-25 | 2010-09-22 | Amgen Inc | Anticuerpos de ferroportina y metodos de uso. |
| NZ600205A (en) * | 2008-01-25 | 2013-12-20 | Univ Aarhus | Selective exosite inhibition of papp-a activity against igfbp-4 |
| TWI472339B (zh) | 2008-01-30 | 2015-02-11 | Genentech Inc | 包含結合至ｈｅｒ２結構域ii之抗體及其酸性變異體的組合物 |
| SG187517A1 (en) | 2008-01-31 | 2013-02-28 | Genentech Inc | Anti-cd79b antibodies and immunoconjugates and methods of use |
| KR20100115360A (ko) | 2008-02-05 | 2010-10-27 | 브리스톨-마이어스 스큅 컴퍼니 | 알파 ５-베타 １ 항체 및 이의 용도 |
| JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
| WO2009108637A1 (en) | 2008-02-25 | 2009-09-03 | Prometheus Laboratories, Inc. | Drug selection for breast cancer therapy using antibody-based arrays |
| RU2467765C2 (ru) | 2008-03-04 | 2012-11-27 | Пфайзер Лимитед | Способы лечения воспалительной боли |
| ES2689322T3 (es) | 2008-03-04 | 2018-11-13 | Teva Pharmaceuticals International Gmbh | Métodos para tratar el dolor crónico |
| WO2009111644A2 (en) * | 2008-03-05 | 2009-09-11 | The Regents Of The University Of Michigan | Compositions and methods for diagnosing and treating pancreatic cancer |
| AU2009223688B2 (en) | 2008-03-10 | 2014-12-11 | Theraclone Sciences, Inc. | Compositions and methods for the therapy and diagnosis of cytomegalovirus infections |
| US8178092B2 (en) | 2008-03-18 | 2012-05-15 | Abbott Laboratories | Methods of treating psoriasis by administration of antibodies to the p40 subunit of IL-12 and/or IL-23 |
| EP2269071B1 (en) | 2008-03-19 | 2014-10-01 | China Synthetic Rubber Corporation | Methods and agents for the diagnosis and treatment of hepatocellular carcinoma |
| EP2274334A2 (en) | 2008-03-28 | 2011-01-19 | Sea Lane Biotechnologies,llc. | Neutralizing molecules to viral antigens |
| US20110123530A1 (en) | 2008-03-31 | 2011-05-26 | Arron Joseph R | Compositions and methods for treating and diagnosing asthma |
| US20090258013A1 (en) | 2008-04-09 | 2009-10-15 | Genentech, Inc. | Novel compositions and methods for the treatment of immune related diseases |
| MX2010011206A (es) | 2008-04-16 | 2010-11-12 | Biogen Idec Inc | Metodo para aislar biomacromoleculas usando glicol de polialquileno y metales de transicion. |
| AU2008201871A1 (en) * | 2008-04-16 | 2009-11-26 | Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts | Inhibition of angiogenesis and tumor metastasis |
| US20090298187A1 (en) | 2008-04-17 | 2009-12-03 | Qiagen Gaithersburg, Inc. | Compositions, methods, and kits using synthetic probes for determining the presence of a target nucleic acid |
| GB0807413D0 (en) | 2008-04-23 | 2008-05-28 | Ucb Pharma Sa | Biological products |
| WO2009134389A2 (en) * | 2008-05-01 | 2009-11-05 | Gtc Biotherapeutics, Inc. | An anti-cd137 antibody as an agent in the treatment of inflammatory conditions |
| MX2010011717A (es) | 2008-05-01 | 2010-11-30 | Amgen Inc | Anticuerpos anti-hepcidina y metodos de uso. |
| SG176464A1 (en) | 2008-05-09 | 2011-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
| KR101511453B1 (ko) | 2008-05-16 | 2015-04-10 | 제넨테크, 인크. | 베타7 인테그린 길항제를 이용한 위장관 염증 장애의 치료를 평가하기 위한 바이오마커의 용도 |
| US8082730B2 (en) * | 2008-05-20 | 2011-12-27 | Caterpillar Inc. | Engine system having particulate reduction device and method |
| US8093018B2 (en) | 2008-05-20 | 2012-01-10 | Otsuka Pharmaceutical Co., Ltd. | Antibody identifying an antigen-bound antibody and an antigen-unbound antibody, and method for preparing the same |
| JOP20190083A1 (ar) | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
| WO2009150623A1 (en) | 2008-06-13 | 2009-12-17 | Pfizer Inc | Treatment of chronic prostatitis |
| WO2009156994A1 (en) * | 2008-06-24 | 2009-12-30 | Hadasit Medical Research Services And Development Ltd. | Ccl20-specific antibodies for cancer therapy |
| EP2899211A1 (en) | 2008-07-08 | 2015-07-29 | OncoMed Pharmaceuticals, Inc. | Notch1 receptor binding agents and methods of use thereof |
| DK2318832T3 (da) | 2008-07-15 | 2014-01-20 | Academia Sinica | Glycan-arrays på PTFE-lignende aluminiumcoatede objektglas og relaterede fremgangsmåder |
| US7981627B2 (en) * | 2008-07-17 | 2011-07-19 | Ramot At Tel-Aviv University Ltd. | Methods for diagnosing and monitoring liver diseases |
| EP2323679A4 (en) | 2008-07-25 | 2012-08-22 | Univ Colorado | CLIP HEMMER AND METHOD FOR MODULATING THE IMMUNE FUNCTION |
| UA105009C2 (uk) | 2008-08-05 | 2014-04-10 | Новартіс Аг | Композиції та способи, призначені для спрямованого впливу антитіл на білок с5 системи комплементу |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| WO2010019702A2 (en) | 2008-08-12 | 2010-02-18 | Oncomed Pharmaceuticals, Inc. | Ddr1-binding agents and methods of use thereof |
| WO2010017598A1 (en) | 2008-08-14 | 2010-02-18 | Arana Therapeutics Limited | Anti-il-12/il-23 antibodies |
| RU2547595C2 (ru) | 2008-08-18 | 2015-04-10 | Пфайзер Инк | Антитела против ccr2 |
| EP2328928A2 (en) | 2008-08-25 | 2011-06-08 | Dana-Farber Cancer Institute, Inc. | Conserved influenza hemagglutinin epitope and antibodies thereto |
| BRPI0918648A2 (pt) | 2008-09-03 | 2019-09-03 | Genentech Inc | anticorpos multiespecíficos |
| EP2326350B1 (en) | 2008-09-08 | 2013-09-04 | Psma Development Company, L.L.C. | Compounds for killing psma-expressing, taxane-resistant cancer cells |
| CN102149728B (zh) | 2008-09-10 | 2014-10-15 | 霍夫曼-拉罗奇有限公司 | 抑制眼部血管生成的方法 |
| TWI516501B (zh) | 2008-09-12 | 2016-01-11 | 禮納特神經系統科學公司 | Ｐｃｓｋ９拮抗劑類 |
| TW201438738A (zh) | 2008-09-16 | 2014-10-16 | Genentech Inc | 治療進展型多發性硬化症之方法 |
| KR20110057244A (ko) | 2008-09-19 | 2011-05-31 | 메디뮨 엘엘씨 | Ｄｌｌ4에 대한 항체 및 이의 용도 |
| CA2738019A1 (en) | 2008-09-23 | 2010-04-08 | President And Fellows Of Harvard College | Sirt4 and uses thereof |
| WO2010036959A2 (en) | 2008-09-26 | 2010-04-01 | Dana-Farber Cancer Institute | Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses therefor |
| WO2010037046A1 (en) | 2008-09-28 | 2010-04-01 | Fraunhofer Usa, Inc. | Humanized neuraminidase antibody and methods of use thereof |
| DK2346994T3 (da) | 2008-09-30 | 2022-02-28 | Ablexis Llc | Knock-in-mus til fremstilling af kimære antistoffer |
| CA2739076A1 (en) | 2008-10-02 | 2010-04-08 | Celtaxsys, Inc. | Methods of modulating the negative chemotaxis of immune cells |
| EP3025727A1 (en) | 2008-10-02 | 2016-06-01 | The J. David Gladstone Institutes | Methods of treating liver disease |
| NZ592009A (en) | 2008-10-10 | 2012-11-30 | Amgen Inc | Fgf21 mutants and uses thereof |
| CN110317272A (zh) | 2008-10-14 | 2019-10-11 | 霍夫曼-拉罗奇有限公司 | 免疫球蛋白变体及其用途 |
| WO2010045321A2 (en) * | 2008-10-15 | 2010-04-22 | Baxter International Inc. | Pegylation of recombinant blood coagulation factors in the presence of bound antibodies |
| BRPI0920582A2 (pt) * | 2008-10-16 | 2019-08-27 | Cytonics Corp | biomarcadores e métodos de detecção e tratamento da dor espinhal e de articulação |
| US8871202B2 (en) | 2008-10-24 | 2014-10-28 | Lpath, Inc. | Prevention and treatment of pain using antibodies to sphingosine-1-phosphate |
| ES2622062T3 (es) * | 2008-10-27 | 2017-07-05 | Qiagen Gaithersburg, Inc. | Ensayo y sistema de captura de híbrido de resultados rápidos |
| EP2348827B1 (en) | 2008-10-27 | 2015-07-01 | Revivicor, Inc. | Immunocompromised ungulates |
| DK3199553T3 (da) | 2008-10-29 | 2019-07-22 | Circular Commitment Company | Fremgangsmåder og midler til diagnosticering og behandling af hepatocellulært carcinom |
| LT2894165T (lt) | 2008-11-10 | 2023-03-10 | Alexion Pharmaceuticals, Inc. | Būdai ir kompozicijos, skirti su komplementu susijusių sutrikimų gydymui |
| SG10201701954QA (en) | 2008-11-11 | 2017-05-30 | Univ Michigan | Anti-cxcr1 compositions and methods |
| CN102215869B (zh) | 2008-11-13 | 2015-05-13 | 通用医疗公司 | 用于通过调整bmp-6来调节铁稳态的方法和组合物 |
| WO2010058396A1 (en) | 2008-11-19 | 2010-05-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | A cd44vra antibody and diagnostic and therapeutic methods using same |
| AR074369A1 (es) * | 2008-11-20 | 2011-01-12 | Genentech Inc | Anticuerpos anti-unc 5b (receptor de netrina) y metodos de uso |
| CN102223897B (zh) | 2008-11-22 | 2015-09-23 | 霍夫曼-拉罗奇有限公司 | 抗-vegf抗体与化学治疗联合用于治疗乳腺癌的应用 |
| WO2010062960A2 (en) | 2008-11-26 | 2010-06-03 | Cedars-Sinai Medical Center | METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE |
| WO2010062858A1 (en) * | 2008-11-26 | 2010-06-03 | Allergan, Inc. | Il-17 antibody inhibitor for treating dry eye |
| WO2010062857A1 (en) | 2008-11-26 | 2010-06-03 | Allergan, Inc. | Klk-13 antibody inhibitor for treating dry eye |
| KR20110096553A (ko) * | 2008-11-28 | 2011-08-30 | 아보트 러보러터리즈 | 안정한 항체 조성물 및 이의 안정화 방법 |
| WO2010061393A1 (en) | 2008-11-30 | 2010-06-03 | Compugen Ltd. | He4 variant nucleotide and amino acid sequences, and methods of use thereof |
| EP2373687B1 (en) | 2008-12-03 | 2016-10-26 | Genmab A/S | Igg4 antibody variants having modifications in the constant region |
| CA2745436A1 (en) * | 2008-12-05 | 2010-06-10 | Lpath, Inc. | Antibody design using anti-lipid antibody crystal structures |
| US8401799B2 (en) * | 2008-12-05 | 2013-03-19 | Lpath, Inc. | Antibody design using anti-lipid antibody crystal structures |
| AU2009325878B2 (en) | 2008-12-08 | 2014-01-16 | Compugen Ltd. | TMEM154 polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics |
| UA109633C2 (uk) | 2008-12-09 | 2015-09-25 | Антитіло людини проти тканинного фактора | |
| KR20210060670A (ko) | 2008-12-09 | 2021-05-26 | 제넨테크, 인크. | 항-ｐｄ-ｌ１ 항체 및 ｔ 세포 기능을 향상시키기 위한 그의 용도 |
| EP2376117A1 (en) | 2008-12-17 | 2011-10-19 | Genentech, Inc. | Hepatitis c virus combination therapy |
| MX2011007660A (es) | 2008-12-18 | 2011-08-17 | Kingdon Craig R | Animales transgenicos no humanos que expresan anticuerpos humanizados y usos de los mismos. |
| WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
| AU2009329866B2 (en) | 2008-12-23 | 2016-09-29 | Genentech, Inc. | Immunoglobulin variants with altered binding to protein A |
| WO2010072740A2 (en) | 2008-12-23 | 2010-07-01 | Astrazeneca Ab | TARGETED BINDING AGENTS DIRECTED TO α5β1 AND USES THEREOF |
| JO3382B1 (ar) | 2008-12-23 | 2019-03-13 | Amgen Inc | أجسام مضادة ترتبط مع مستقبل cgrp بشري |
| KR20140020368A (ko) | 2008-12-23 | 2014-02-18 | 제넨테크, 인크. | 암 환자에서의 진단 목적용 방법 및 조성물 |
| CA2748149C (en) | 2008-12-24 | 2018-03-06 | Netherlands Vaccine Institute | Modified steptococcus pneumonia pneumolysin (ply) polypeptides |
| EP2808402A3 (en) | 2008-12-29 | 2015-03-25 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Methods of predicting responsiveness to interferon treatment |
| US20110142836A1 (en) * | 2009-01-02 | 2011-06-16 | Olav Mella | B-cell depleting agents for the treatment of chronic fatigue syndrome |
| US9107935B2 (en) * | 2009-01-06 | 2015-08-18 | Gilead Biologics, Inc. | Chemotherapeutic methods and compositions |
| GB0900425D0 (en) | 2009-01-12 | 2009-02-11 | Ucb Pharma Sa | Biological products |
| JP2012516155A (ja) | 2009-01-27 | 2012-07-19 | キアゲン ゲーザーズバーグ | エンドポイント均一蛍光検出を用いた好熱性ヘリカーゼ依存性増幅技術 |
| ES2644516T3 (es) * | 2009-01-28 | 2017-11-29 | Qiagen Gaithersburg, Inc. | Método y ensayo de preparación de muestras de gran volumen específico de secuencia |
| WO2010086828A2 (en) | 2009-02-02 | 2010-08-05 | Rinat Neuroscience Corporation | Agonist anti-trkb monoclonal antibodies |
| WO2010093814A1 (en) | 2009-02-11 | 2010-08-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a gm-csf antagonist |
| DK2396652T3 (da) | 2009-02-11 | 2018-01-29 | Cedars Sinai Medical Center | Diagnose af inflammatorisk tarmsyndrom baseret på cytoletalt udspilende toksin |
| CA2751477C (en) | 2009-02-17 | 2019-08-27 | Ucb Pharma S.A. | Antibody molecules having specificity for human ox40 |
| US8648176B2 (en) | 2009-02-27 | 2014-02-11 | Massachusetts Institute Of Technology | Engineered proteins with high affinity for DOTA chelates |
| PL2403878T3 (pl) | 2009-03-05 | 2017-12-29 | E. R. Squibb & Sons, L.L.C. | W pełni ludzkie przeciwciała specyficzne dla CADM1 |
| EA201101241A1 (ru) | 2009-03-06 | 2012-04-30 | Калобайос Фармасьютиклз, Инк. | Лечение лейкозов и хронических миелопролиферативных болезней антителами к ерна3 |
| CN102741295A (zh) | 2009-03-10 | 2012-10-17 | 贝勒研究院 | 靶向抗原呈递细胞的抗病毒疫苗 |
| CA3032548C (en) | 2009-03-10 | 2023-05-09 | Baylor Research Institute | Anti-cd40 antibodies and uses thereof |
| JP5986382B2 (ja) | 2009-03-10 | 2016-09-06 | ベイラー リサーチ インスティテュートＢａｙｌｏｒ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ | 抗原提示細胞ターゲティング癌ワクチン |
| GB0904214D0 (en) | 2009-03-11 | 2009-04-22 | Ucb Pharma Sa | Biological products |
| SI3260136T1 (sl) | 2009-03-17 | 2021-05-31 | Theraclone Sciences, Inc. | Humani imunodeficientni virus (HIV)-nevtralizirajoča protitelesa |
| JP5799394B2 (ja) | 2009-03-18 | 2015-10-28 | オンコセラピー・サイエンス株式会社 | Ｎｅｉｌ３ペプチドおよびそれを含むワクチン |
| JP2012521197A (ja) | 2009-03-20 | 2012-09-13 | アムジエン・インコーポレーテツド | 担体免疫グロブリンおよびその使用 |
| EP2408817B1 (en) | 2009-03-20 | 2016-03-16 | F.Hoffmann-La Roche Ag | Bispecific anti-her antibodies |
| WO2010113096A1 (en) | 2009-03-30 | 2010-10-07 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Methods of predicting clinical course and treating multiple sclerosis |
| MA33248B1 (fr) | 2009-04-01 | 2012-05-02 | Genentech Inc | Traitement de troubles résistant à l'insuline |
| CN102448484A (zh) | 2009-04-01 | 2012-05-09 | 医学研究，基础设施和卫生服务基金的特拉维夫医疗中心 | 调节角质化细胞增生和分化的方法 |
| PE20120878A1 (es) | 2009-04-01 | 2012-08-06 | Genentech Inc | ANTICUERPOS ANTI-FcRH5 E INMUNOCONJUGADOS |
| WO2010112034A2 (en) | 2009-04-02 | 2010-10-07 | Aarhus Universitet | Compositions and methods for treatment and diagnosis of synucleinopathies |
| US20100297127A1 (en) | 2009-04-08 | 2010-11-25 | Ghilardi Nico P | Use of il-27 antagonists to treat lupus |
| WO2010116375A1 (en) | 2009-04-08 | 2010-10-14 | Yeda Research And Development Co. Ltd. | Isolated peptides for regulating apoptosis |
| EP3831407A1 (en) | 2009-04-08 | 2021-06-09 | LipUm AB | New methods for treatment of inflammatory diseases |
| KR101787768B1 (ko) | 2009-04-18 | 2017-10-18 | 제넨테크, 인크. | 항-ｃｄ４０ 항체를 사용한 치료에 대한 ｂ-세포 림프종의 반응성 평가를 위한 방법 |
| CA2759506A1 (en) * | 2009-04-23 | 2010-10-28 | Theraclone Sciences, Inc. | Granulocyte-macrophage colony-stimulating factor (gm-csf) neutralizing antibodies |
| WO2010124113A1 (en) | 2009-04-23 | 2010-10-28 | Infinity Pharmaceuticals, Inc. | Anti-fatty acid amide hydrolase-2 antibodies and uses thereof |
| BRPI1014522B8 (pt) | 2009-04-27 | 2021-05-25 | Novartis Ag | anticorpo anti-actriib ou fragmento funcional, processo de produção dos mesmos, composição farmacêutica e usos |
| EP2424567B1 (en) | 2009-04-27 | 2018-11-21 | OncoMed Pharmaceuticals, Inc. | Method for making heteromultimeric molecules |
| BRPI1016055A2 (pt) | 2009-04-27 | 2016-05-10 | Novartis Ag | composição e métodos de uso para anticorpos terapêuticos específicos para a subunidade beta i do receptor de il-12 |
| PL2424896T3 (pl) | 2009-04-30 | 2016-03-31 | Tel Hashomer Medical Res Infrastructure & Services Ltd | Przeciwciała anty-ceacam1 oraz sposoby ich stosowania |
| JP5738278B2 (ja) * | 2009-05-01 | 2015-06-24 | キアジェン ゲイサーズバーグ インコーポレイテッド | 試料中のｒｎａスプライシング形態を検出するための非標的増幅法 |
| NZ596839A (en) | 2009-05-04 | 2014-01-31 | Abbott Res Bv | Antibodies against nerve growth factor (ngf) with enhanced in vivo stability |
| CN104974250A (zh) | 2009-05-05 | 2015-10-14 | 诺维莫尼公司 | 抗il-17f抗体及其使用方法 |
| AU2010246038A1 (en) | 2009-05-05 | 2011-12-01 | Amgen Inc. | FGF21 mutants and uses thereof |
| SI3248610T1 (sl) | 2009-05-05 | 2024-03-29 | Amgen Inc., | Mutanti fgf21 in njihove uporabe |
| CA2762302A1 (en) | 2009-05-20 | 2010-11-25 | Theraclone Sciences, Inc. | Compositions and methods for the therapy and diagnosis of influenza |
| KR101224468B1 (ko) | 2009-05-20 | 2013-01-23 | 주식회사 파멥신 | 신규한 형태의 이중표적항체 및 그 용도 |
| TWI507204B (zh) | 2009-05-26 | 2015-11-11 | Oncotherapy Science Inc | Ｃｄｃ４５ｌ胜肽與含此胜肽之疫苗 |
| US20120070449A1 (en) | 2009-05-28 | 2012-03-22 | Yeda Research And Development Co. Ltd. | Methods of treating inflammation |
| US8680055B2 (en) | 2009-06-03 | 2014-03-25 | University Of Southern California | Methods for decreasing steroidogenesis in prostate cancer cells |
| EP2440234A4 (en) | 2009-06-10 | 2013-11-06 | Univ New York | IMMUNOLOGICAL TARGETING OF PATHOLOGICAL TAU PROTEINS |
| US20100316639A1 (en) | 2009-06-16 | 2010-12-16 | Genentech, Inc. | Biomarkers for igf-1r inhibitor therapy |
| US8324160B2 (en) | 2009-06-17 | 2012-12-04 | Amgen Inc. | Chimeric polypeptides and uses thereof |
| WO2010146511A1 (en) | 2009-06-17 | 2010-12-23 | Pfizer Limited | Treatment of overactive bladder |
| WO2010148117A1 (en) | 2009-06-17 | 2010-12-23 | Scantibodies Laboratory, Inc. | Therapeutic and diagnostic affinity purified specific polyclonal antibodies |
| TWI513465B (zh) | 2009-06-25 | 2015-12-21 | Regeneron Pharma | 以ｄｌｌ４拮抗劑與化學治療劑治療癌症之方法 |
| US20120101262A1 (en) | 2009-06-25 | 2012-04-26 | Bristol-Myers Squibb Company | Protein purification by caprylic acid (octanoic acid) precipitation |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| US20120204278A1 (en) | 2009-07-08 | 2012-08-09 | Kymab Limited | Animal models and therapeutic molecules |
| DK2517557T4 (da) | 2009-07-08 | 2023-09-25 | Kymab Ltd | Dyremodeller og terapeutiske molekyler |
| WO2011006001A1 (en) | 2009-07-09 | 2011-01-13 | Genentech, Inc. | Animal model for the evaluation of adjuvant therapies of cancer |
| WO2011004379A1 (en) | 2009-07-10 | 2011-01-13 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Compositions and methods for treating cancer |
| BR112012000735A2 (pt) | 2009-07-13 | 2016-11-16 | Genentech Inc | "métodos, kits e conjuntos de compostos" |
| AU2010273319B2 (en) | 2009-07-15 | 2015-01-22 | Nestec S.A. | Drug selection for gastric cancer therapy using antibody-based arrays |
| AU2010276392A1 (en) | 2009-07-20 | 2012-03-08 | Genentech, Inc. | Gene expression markers for Crohn's disease |
| ES2753986T3 (es) | 2009-07-21 | 2020-04-15 | Tel Hashomer Medical Res Infrastructure & Services Ltd | Un método de diagnóstico de cáncer |
| AR077595A1 (es) | 2009-07-27 | 2011-09-07 | Genentech Inc | Tratamientos de combinacion |
| BR112012007875A2 (pt) | 2009-07-31 | 2016-11-22 | Medarex Inc | anticorpos totalmente humanos para btla |
| JP2013500993A (ja) | 2009-07-31 | 2013-01-10 | ジェネンテック， インコーポレイテッド | Ｂｖ８アンタゴニスト又はｇ−ｃｓｆアンタゴニストを用いた腫瘍転移の阻害 |
| HUE038451T2 (hu) | 2009-08-06 | 2018-10-29 | Hoffmann La Roche | Eljárás vírus eltávolításának javítására fehérjetisztítás során |
| WO2011017294A1 (en) | 2009-08-07 | 2011-02-10 | Schering Corporation | Human anti-rankl antibodies |
| US20110039300A1 (en) | 2009-08-10 | 2011-02-17 | Robert Bayer | Antibodies with enhanced adcc functions |
| US20110038871A1 (en) | 2009-08-11 | 2011-02-17 | Veena Viswanth | Ccr2 inhibitors for treating conditions of the eye |
| KR20200111282A (ko) | 2009-08-11 | 2020-09-28 | 제넨테크, 인크. | 글루타민-비함유 세포 배양 배지에서의 단백질의 생성 |
| US8592644B2 (en) | 2009-08-13 | 2013-11-26 | Crystal Bioscience Inc. | Transgenic animal for production of antibodies having minimal CDRS |
| CA2770321A1 (en) | 2009-08-14 | 2011-02-17 | Genentech, Inc. | Biological markers for monitoring patient response to vegf antagonists |
| WO2011019622A1 (en) | 2009-08-14 | 2011-02-17 | Genentech, Inc. | Cell culture methods to make antibodies with enhanced adcc function |
| NZ598131A (en) | 2009-08-15 | 2014-08-29 | Genentech Inc | Anti-angiogenesis therapy for the treatment of previously treated breast cancer |
| WO2011021146A1 (en) | 2009-08-20 | 2011-02-24 | Pfizer Inc. | Osteopontin antibodies |
| US20110044907A1 (en) * | 2009-08-21 | 2011-02-24 | Derek Marshall | In vivo screening assays |
| US20110044981A1 (en) * | 2009-08-21 | 2011-02-24 | Spangler Rhyannon | Methods and compositions for treatment of pulmonary fibrotic disorders |
| US20110207144A1 (en) * | 2009-08-21 | 2011-08-25 | Derek Marshall | In vitro screening assays |
| CN102712683B (zh) | 2009-08-21 | 2014-09-10 | 吉联亚生物科技有限公司 | 赖氨酰氧化酶和loxl2的催化结构域 |
| CA2771630A1 (en) * | 2009-08-21 | 2011-02-24 | Victoria Smith | Therapeutic methods and compositions |
| US8623366B2 (en) | 2009-08-28 | 2014-01-07 | Labrys Biologics, Inc. | Methods for treating visceral pain by administering antagonist antibodies directed against calcitonin gene-related peptide |
| AU2010289400B2 (en) | 2009-09-02 | 2014-10-23 | Curis, Inc. | Mutant smoothened and methods of using the same |
| EP3211094A3 (en) | 2009-09-03 | 2017-11-01 | F. Hoffmann-La Roche AG | Methods for treating, diagnosing, and monitoring rheumatoid arthritis |
| US20120171213A1 (en) | 2009-09-10 | 2012-07-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method of treating tumors |
| US20110064670A1 (en) | 2009-09-11 | 2011-03-17 | Genentech, Inc. | Method to identify a patient with an increased likelihood of responding to an anti-cancer agent |
| AU2010291927A1 (en) * | 2009-09-14 | 2012-04-12 | AbbVie Deutschland GmbH & Co. KG | Methods for treating psoriasis |
| EP2478087B1 (en) | 2009-09-14 | 2017-01-18 | QIAGEN Gaithersburg, Inc. | Compositions and methods for recovery of nucleic acids or proteins from tissue samples fixed in cytology media |
| MX2012002909A (es) | 2009-09-17 | 2012-04-19 | Hoffmann La Roche | Metodos y composiciones para su uso en diagnostico de pacientes con cancer. |
| EP2480561B1 (en) | 2009-09-23 | 2016-07-13 | E. R. Squibb & Sons, L.L.C. | Cation exchange chromatography |
| US20120183546A1 (en) | 2009-09-23 | 2012-07-19 | Amgen Inc. | Treatment of ovarian cancer using a specific binding agent of human angiopoietin-2 in combination with a taxane |
| GB201005063D0 (en) | 2010-03-25 | 2010-05-12 | Ucb Pharma Sa | Biological products |
| CA2772945A1 (en) | 2009-09-25 | 2011-03-31 | Xoma Technology Ltd. | Screening methods |
| US8926976B2 (en) | 2009-09-25 | 2015-01-06 | Xoma Technology Ltd. | Modulators |
| WO2011041391A1 (en) | 2009-09-29 | 2011-04-07 | Fraunhofer Usa, Inc. | Influenza hemagglutinin antibodies, compositions, and related methods |
| CN102740887B (zh) | 2009-09-30 | 2015-04-15 | 斯隆凯特林防癌纪念中心 | 用于治疗癌症的组合免疫疗法 |
| KR101782180B1 (ko) | 2009-09-30 | 2017-10-23 | 제넨테크, 인크. | Ｎｏｔｃｈ3 길항제를 사용한 Ｎｏｔｃｈ1―길항제-내성 암(들)의 치료 |
| MX2012003770A (es) | 2009-09-30 | 2012-08-03 | Harvard College | Metodos para la modulacion de autofagia a traves de la modulacion de productos de genes que aumentan la autofagia. |
| US20130034544A1 (en) | 2009-10-07 | 2013-02-07 | Genentech, Inc. | Methods for treating, diagnosing, and monitoring lupus |
| EP2488640B1 (en) | 2009-10-14 | 2018-09-26 | Nanyang Technological University | Antiproliferative agent |
| CN102656266B (zh) * | 2009-10-15 | 2016-08-03 | 霍夫曼-拉罗奇有限公司 | 具有改变的受体特异性的嵌合成纤维细胞生长因子 |
| TR201818814T4 (tr) | 2009-10-16 | 2019-01-21 | Oncomed Pharm Inc | Dll4 antagonist antikorlarının ve anti-hipertansif ajanların terapötik kombinasyonu ve kullanımı. |
| EP2491385B1 (en) | 2009-10-20 | 2017-05-10 | DiaTech Holdings, Inc. | Proximity-mediated assays for detecting oncogenic fusion proteins |
| JP5819308B2 (ja) | 2009-10-22 | 2015-11-24 | ジェネンテック， インコーポレイテッド | マクロファージ刺激タンパク質のヘプシン活性化を調節するための方法及び組成物 |
| EA201792376A3 (ru) | 2009-10-23 | 2018-08-31 | Милленниум Фармасьютикалз, Инк. | Молекулы анти-gcc антитела и соответствующие композиции и способы |
| WO2011056497A1 (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Activin receptor type iib compositions and methods of use |
| WO2011056502A1 (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Bone morphogenetic protein receptor type ii compositions and methods of use |
| JO3244B1 (ar) | 2009-10-26 | 2018-03-08 | Amgen Inc | بروتينات ربط مستضادات il – 23 البشرية |
| AU2010315470B2 (en) * | 2009-10-26 | 2016-05-05 | Genentech, Inc. | Assays for detecting antibodies specific to therapeutic anti-IgE antibodies and their use in anaphylaxis |
| WO2011056494A1 (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Activin receptor-like kinase-1 antagonist and vegfr3 antagonist combinations |
| GB0922435D0 (en) | 2009-12-22 | 2010-02-03 | Ucb Pharma Sa | Method |
| GB0922434D0 (en) | 2009-12-22 | 2010-02-03 | Ucb Pharma Sa | antibodies and fragments thereof |
| US9234037B2 (en) | 2009-10-27 | 2016-01-12 | Ucb Biopharma Sprl | Method to generate antibodies to ion channels |
| EP2493926B1 (en) | 2009-10-27 | 2020-03-11 | UCB Biopharma SRL | Function modifying nav 1.7 antibodies |
| CN102648293A (zh) | 2009-10-30 | 2012-08-22 | 加利福尼亚大学董事会 | 黑素瘤中的gna11突变 |
| WO2011057250A1 (en) | 2009-11-09 | 2011-05-12 | Alexion Pharmaceuticals, Inc. | Reagents and methods for detecting pnh type ii white blood cells and their identification as risk factors for thrombotic disorders |
| WO2011060015A1 (en) | 2009-11-11 | 2011-05-19 | Genentech, Inc. | Methods and compositions for detecting target proteins |
| ES2655737T3 (es) | 2009-11-13 | 2018-02-21 | Daiichi Sankyo Europe Gmbh | Materiales y métodos para tratar o prevenir las enfermedades asociadas a HER-3 |
| CA3061784C (en) | 2009-11-13 | 2023-09-26 | Dana-Farber Cancer Institute, Inc. | Compositions, kits, and methods for the diagnosis, prognosis, monitoring, treatment and modulation of post-transplant lymphoproliferative disorders and hypoxia associated angiogenesis disorders using galectin-1 |
| EP3037435B1 (en) | 2009-11-17 | 2019-08-07 | MUSC Foundation for Research Development | Human monoclonal antibodies to human nucleolin |
| EP2502992A4 (en) * | 2009-11-17 | 2013-06-12 | CHROMOSOME ARTIFICIAL HUMAN VECTOR | |
| EP3255153A1 (en) | 2009-11-17 | 2017-12-13 | E. R. Squibb & Sons, L.L.C. | Methods for enhanced protein production |
| AU2010321885B2 (en) | 2009-11-20 | 2015-12-24 | The Regents Of The University Of California | Epithelial membrane protein-2 (EMP2) and proliferative vitreoretinopathy (PVR) |
| AU2010321832B2 (en) | 2009-11-20 | 2014-08-14 | Amgen Inc. | Anti-Orai1 antigen binding proteins and uses thereof |
| WO2011066389A1 (en) | 2009-11-24 | 2011-06-03 | Medimmmune, Limited | Targeted binding agents against b7-h1 |
| MX338694B (es) | 2009-11-30 | 2016-04-27 | Genentech Inc | Composiciones y metodos para el diagnostico y el tratamiento de tumores. |
| WO2011068870A2 (en) | 2009-12-01 | 2011-06-09 | President And Fellows Of Harvard College | Modulation of nk cell antigen specific effector activity by modulation of cxcr6 (cd186) |
| WO2011067711A2 (en) | 2009-12-01 | 2011-06-09 | Compugen Ltd | Novel heparanase splice variant |
| CA2782814A1 (en) * | 2009-12-02 | 2011-06-09 | Amgen Inc. | Binding proteins that bind to human fgfr1c, human .beta.-klotho and both human fgfr1c and human .beta.-klotho |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| UA109888C2 (uk) | 2009-12-07 | 2015-10-26 | ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ | |
| ES2565208T3 (es) | 2009-12-11 | 2016-04-01 | F. Hoffmann-La Roche Ag | Anticuerpos anti-VEGF-C y métodos de uso de los mismos |
| TW201136604A (en) | 2009-12-14 | 2011-11-01 | Oncotherapy Science Inc | TMEM22 peptides and vaccines including the same |
| WO2011084750A1 (en) | 2009-12-21 | 2011-07-14 | Genentech, Inc. | Antibody formulation |
| GB0922377D0 (en) | 2009-12-22 | 2010-02-03 | Arab Gulf University The | Mutant LDL receptor |
| US20110165161A1 (en) * | 2009-12-23 | 2011-07-07 | Shih-Yao Lin | Anti-epcam antibodies that induce apoptosis of cancer cells and methods using same |
| DK2516465T3 (en) | 2009-12-23 | 2016-06-06 | Hoffmann La Roche | ANTI-BV8 ANTIBODIES AND APPLICATIONS THEREOF |
| WO2011082187A1 (en) | 2009-12-30 | 2011-07-07 | Genentech, Inc. | Methods for modulating a pdgf-aa mediated biological response |
| IN2012DN06309A (ja) | 2010-01-11 | 2015-09-25 | Alexion Pharma Inc | |
| EP2523682B1 (en) | 2010-01-13 | 2015-12-16 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
| US8865462B2 (en) * | 2010-01-20 | 2014-10-21 | Crystal Bioscience Inc. | Sustained culture of avian gonocytes |
| TWI485245B (zh) | 2010-01-25 | 2015-05-21 | Oncotherapy Science Inc | 經修飾之ｍｅｌｋ胜肽及含此胜肽之疫苗 |
| CN102822202B (zh) | 2010-01-27 | 2015-07-22 | 耶达研究及发展有限公司 | 抑制金属蛋白的抗体 |
| JP6103941B2 (ja) | 2010-01-29 | 2017-03-29 | キアジェン ゲイサーズバーグ インコーポレイテッド | 核酸の配列特異的精製および多重分析のための方法および組成物 |
| US9605303B2 (en) | 2010-01-29 | 2017-03-28 | Qiagen Gaithersburg, Inc. | Method of determining and confirming the presence of an HPV in a sample |
| WO2011094759A2 (en) | 2010-02-01 | 2011-08-04 | The Regents Of The University Of California | Novel diagnostic and therapeutic targets associated with or regulated by n-cadherin expression and/or epithelial to mesenchymal transition (emt) in prostate cancer and other malignancies |
| CN105622757A (zh) | 2010-02-04 | 2016-06-01 | 吉联亚生物科技有限公司 | 结合赖氨酰氧化酶样2（loxl2）的抗体和其使用方法 |
| HUE029785T2 (en) | 2010-02-08 | 2017-04-28 | Regeneron Pharma | Common mouse light chain |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| BR112012020102A2 (pt) | 2010-02-10 | 2016-11-29 | Immunogen Inc | anticorpos cd20 e usos dos mesmos. |
| US8551715B2 (en) | 2010-02-12 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for identifying and isolating cells expressing a polypeptide |
| EP3178846B1 (en) | 2010-02-17 | 2018-08-22 | Cedars-Sinai Medical Center | Novel phosphorylation of cardiac troponin i as a monitor for cardiac injury |
| CA2790488C (en) | 2010-02-18 | 2018-09-25 | The Regents Of The University Of California | Integrin .alpha.v.beta.8 neutrilizing antibody |
| WO2011103426A2 (en) | 2010-02-19 | 2011-08-25 | The Board Of Regents Of The University Of Oklahoma | Monoclonal antibodies that inhibit the wnt signaling pathway and methods of production and use thereof |
| CN102985113B (zh) | 2010-02-23 | 2015-05-20 | 霍夫曼-拉罗奇有限公司 | 用于肿瘤诊断和治疗的组合物和方法 |
| CN103237810A (zh) | 2010-02-23 | 2013-08-07 | 霍夫曼-拉罗奇有限公司 | 用于治疗卵巢癌的抗血管发生疗法 |
| US9260529B2 (en) | 2010-02-24 | 2016-02-16 | The University Of Washington Through Its Center For Commercialization | Molecules that bind CD180, compositions and methods of use |
| US8298535B2 (en) | 2010-02-24 | 2012-10-30 | Rinat Neuroscience Corp. | Anti-IL-7 receptor antibodies |
| KR101637138B1 (ko) | 2010-02-24 | 2016-07-06 | 이뮤노젠 아이엔씨 | 엽산염 수용체 1 항체와 면역접합체 및 이들의 용도 |
| US9328162B2 (en) | 2010-02-25 | 2016-05-03 | Schepens Eye Research Institute | Therapeutic compositions for the treatment of dry eye disease |
| WO2011107939A1 (en) | 2010-03-01 | 2011-09-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods of predicting efficacy of an anti-vegfa treatment for solid tumors |
| TW201132813A (en) | 2010-03-03 | 2011-10-01 | Koo Foundation Sun Yat Sen Cancer Ct | Methods for classifying and treating breast cancers |
| US20110236386A1 (en) * | 2010-03-04 | 2011-09-29 | Zimering Mark B | Novel method for prediction of cardiovascular disease risk in type 2 diabetes |
| CN103003307B (zh) | 2010-03-10 | 2017-08-11 | 根马布股份公司 | 抗c‑MEt的单克隆抗体 |
| KR20150002894A (ko) | 2010-03-11 | 2015-01-07 | 리나트 뉴로사이언스 코프. | ｐＨ 의존성 항원 결합을 갖는 항체 |
| EP2545171B1 (en) | 2010-03-11 | 2017-12-20 | OncoTherapy Science, Inc. | Hjurp peptides and vaccines including the same |
| AR080513A1 (es) | 2010-03-12 | 2012-04-11 | Inmunogen Inc | Moleculas de union cd37 y sus inmunoconjugados |
| CN102892430A (zh) | 2010-03-17 | 2013-01-23 | 雅培研究有限公司 | 抗神经生长因子（ngf）抗体组合物 |
| GB201005064D0 (en) | 2010-03-25 | 2010-05-12 | Ucb Pharma Sa | Biological products |
| US10472426B2 (en) | 2010-03-25 | 2019-11-12 | Ucb Biopharma Sprl | Disulfide stabilized DVD-Ig molecules |
| US20150231215A1 (en) | 2012-06-22 | 2015-08-20 | Randolph J. Noelle | VISTA Antagonist and Methods of Use |
| CA3079122A1 (en) | 2010-03-26 | 2011-09-29 | Trustees Of Dartmouth College | Vista regulatory t cell mediator protein, vista binding agents and use thereof |
| US10745467B2 (en) | 2010-03-26 | 2020-08-18 | The Trustees Of Dartmouth College | VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders |
| KR101830020B1 (ko) | 2010-03-31 | 2018-02-19 | 아블렉시스, 엘엘씨 | 키메라 항체의 제조를 위한 비-인간 동물의 유전적 조작 |
| WO2011130332A1 (en) | 2010-04-12 | 2011-10-20 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| KR101958753B1 (ko) | 2010-04-13 | 2019-03-15 | 셀덱스 쎄라퓨틱스, 인크. | 인간 ｃｄ27에 결합하는 항체 및 이의 용도 |
| EP3670534A3 (en) | 2010-04-15 | 2020-09-09 | Amgen Inc. | Human fgf receptor and beta-klotho binding proteins |
| EP2558493B1 (en) | 2010-04-15 | 2019-09-18 | Progenics Pharmaceuticals, Inc. | Antibodies for the treatment of clostridium difficile-associated infection and disease |
| CA2792826A1 (en) | 2010-04-18 | 2011-10-27 | Yeda Research And Development Co. Ltd. | Molecules and methods of using same for treating erbb/erbb ligands associated diseases |
| SG10201800757TA (en) | 2010-04-20 | 2018-02-27 | Genmab As | Heterodimeric antibody fc-containing proteins and methods for production thereof |
| WO2011133931A1 (en) | 2010-04-22 | 2011-10-27 | Genentech, Inc. | Use of il-27 antagonists for treating inflammatory bowel disease |
| CA2797856C (en) | 2010-04-30 | 2018-09-18 | Alexion Pharmaceuticals, Inc. | Anti-c5a antibodies and methods for using the antibodies |
| EP2566891B1 (en) | 2010-05-03 | 2016-11-02 | University Of Rochester | Anti-glucosaminidase passive immunization for staphylococcus aureus infections |
| RU2012151500A (ru) | 2010-05-03 | 2014-06-10 | Дженентек, Инк. | Композиции и способы, пригодные для снижения вязкости белковосодержащих составов |
| TWI713942B (zh) | 2010-05-04 | 2020-12-21 | 美商戊瑞治療有限公司 | 與集落刺激因子１受體（ｃｓｆ１ｒ）結合之抗體類 |
| KR20130060223A (ko) | 2010-05-04 | 2013-06-07 | 메리맥 파마슈티컬즈, 인크. | 상피세포 성장인자 수용체(ｅｇｆｒ)에 대한 항체 및 이의 용도 |
| WO2011140151A1 (en) | 2010-05-04 | 2011-11-10 | Dyax Corp. | Antibodies against epidermal growth factor receptor (egfr) |
| US9290573B2 (en) | 2010-05-06 | 2016-03-22 | Novartis Ag | Therapeutic low density lipoprotein-related protein 6 (LRP6) multivalent antibodies |
| SG185416A1 (en) | 2010-05-06 | 2012-12-28 | Novartis Ag | Compositions and methods of use for therapeutic low density lipoprotein -related protein 6 (lrp6) antibodies |
| EP2568976B1 (en) | 2010-05-10 | 2015-09-30 | Academia Sinica | Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses |
| WO2011146568A1 (en) | 2010-05-19 | 2011-11-24 | Genentech, Inc. | Predicting response to a her inhibitor |
| JP2013528049A (ja) | 2010-05-19 | 2013-07-08 | キアゲン ガイサーズバーグ アイエヌシー． | 核酸の配列特異的な精製及び多重分析のための方法及び組成物 |
| BR112012029904A2 (pt) | 2010-05-25 | 2017-08-08 | Genentech Inc | métodos de purificação de polipeptídeos |
| JP6153866B2 (ja) | 2010-05-25 | 2017-06-28 | キアゲン ガイサーズバーグ アイエヌシー． | 迅速なハイブリッド捕捉アッセイ、及び関連する戦略的に切断されたプローブ |
| WO2011149461A1 (en) | 2010-05-27 | 2011-12-01 | Medtronic, Inc. | Anti-amyloid beta antibodies conjugated to sialic acid-containing molecules |
| JP6320753B2 (ja) | 2010-05-27 | 2018-05-09 | ゲンマブ エー／エス | Ｈｅｒ２に対するモノクローナル抗体 |
| JP6082344B2 (ja) | 2010-05-27 | 2017-02-15 | ゲンマブ エー／エス | Ｈｅｒ２エピトープに対するモノクローナル抗体 |
| EP2576622A4 (en) | 2010-06-01 | 2013-11-27 | Univ Monash | ANTIBODIES AGAINST RECEPTOR TYROSINE KINASE C-MET |
| WO2011153243A2 (en) | 2010-06-02 | 2011-12-08 | Genentech, Inc. | Anti-angiogenesis therapy for treating gastric cancer |
| EP3957653A1 (en) | 2010-06-02 | 2022-02-23 | Dana Farber Cancer Institute, Inc. | Humanized monoclonal antibodies and methods of use |
| WO2011153224A2 (en) | 2010-06-02 | 2011-12-08 | Genentech, Inc. | Diagnostic methods and compositions for treatment of cancer |
| CN103037891A (zh) | 2010-06-03 | 2013-04-10 | 雷蒙特亚特特拉维夫大学有限公司 | 治疗糖尿病的方法和能够治疗糖尿病的组合物 |
| NZ701208A (en) | 2010-06-03 | 2016-05-27 | Genentech Inc | Immuno-pet imaging of antibodies and immunoconjugates and uses thereof |
| EP2580243B1 (en) | 2010-06-09 | 2019-10-16 | Genmab A/S | Antibodies against human cd38 |
| NO2582728T3 (ja) | 2010-06-15 | 2018-01-20 | ||
| US20110311527A1 (en) | 2010-06-16 | 2011-12-22 | Allergan, Inc. | IL23p19 ANTIBODY INHIBITOR FOR TREATING OCULAR AND OTHER CONDITIONS |
| BR112012033248A2 (pt) * | 2010-06-22 | 2017-11-28 | Regeneron Pharma | camundongos expressando uma cadeia leve com variável de lâmbda humana e regiões constantes de camundongo |
| EP3327035A1 (en) | 2010-06-22 | 2018-05-30 | Precision Biologics Inc. | Colon and pancreas cancer specific antigens and antibodies |
| CN103249432A (zh) | 2010-06-22 | 2013-08-14 | 科罗拉多大学董事会,法人团体 | 补体成分3的C3d片段的抗体 |
| JP2013530981A (ja) | 2010-06-25 | 2013-08-01 | アストン ユニバーシティ | 脂質動員特性を有する糖タンパク質およびその治療的使用 |
| WO2012012141A1 (en) | 2010-06-30 | 2012-01-26 | Amgen Inc. | Scnn1a/tnfrsf1a fusion proteins in cancer |
| EP2588631A4 (en) | 2010-07-01 | 2013-11-20 | Univ California | GENETIC MUTATION OF CK2 PROTEIN KINASE, AMPLIFICATIONS AND POLYMORPHISMS IN HUMAN CANCER, AND METHODS OF USE |
| US20120100166A1 (en) | 2010-07-15 | 2012-04-26 | Zyngenia, Inc. | Ang-2 Binding Complexes and Uses Thereof |
| CA2805479A1 (en) | 2010-07-15 | 2012-01-19 | Technion Research & Development Foundation Ltd. | Isolated high affinity entities with t-cell receptor like specificity towards native complexes of mhc class ii and glutamic acid decarboxylase (gad) autoantigenic peptides |
| EP2593480A2 (en) | 2010-07-15 | 2013-05-22 | Technion Research & Development Foundation Ltd. | Antibodies with t-cell receptor like specificity towards native complexes of mhc class ii and diabetes-associated autoantigenic peptides |
| CN103153331B (zh) | 2010-07-15 | 2017-03-22 | 亚德赫伦医疗公司 | 靶向于钙粘着蛋白‑11的ec1结构域的人源化抗体及相关组合物和方法 |
| CN104965084B (zh) | 2010-07-19 | 2017-09-29 | 霍夫曼-拉罗奇有限公司 | 鉴定响应抗癌疗法的可能性升高的患者的方法 |
| WO2012010549A1 (en) | 2010-07-19 | 2012-01-26 | F. Hoffmann-La Roche Ag | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
| US9624469B2 (en) | 2010-07-22 | 2017-04-18 | Cellect Biotherapeutics Ltd. | Regulatory immune cells with enhanced targeted cell death effect |
| JP2013538191A (ja) | 2010-07-23 | 2013-10-10 | トラスティーズ オブ ボストン ユニバーシティ | 病的血管新生および腫瘍細胞侵襲性の阻害のための治療法としてならびに分子イメージングおよび標的化送達のための抗ＤＥｓｕｐＲ阻害剤 |
| KR20130097156A (ko) | 2010-07-26 | 2013-09-02 | 트리아니, 인코포레이티드 | 트랜스제닉 동물 및 이의 사용 방법 |
| US10793829B2 (en) | 2010-07-26 | 2020-10-06 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| EP2598126A2 (en) | 2010-07-30 | 2013-06-05 | Saint Louis University | Methods of treating pain |
| EP2601298B1 (en) | 2010-08-02 | 2016-11-30 | Regeneron Pharmaceuticals, Inc. | Mice that make binding proteins comprising vl domains |
| WO2012019024A2 (en) | 2010-08-04 | 2012-02-09 | Immunogen, Inc. | Her3-binding molecules and immunoconjugates thereof |
| EP2600885A2 (en) | 2010-08-04 | 2013-06-12 | Ramot at Tel Aviv University, Ltd. | Methods of treating autoimmune diseases of the central nervous system (cns) and neurodegenerative diseases |
| WO2012019061A2 (en) | 2010-08-05 | 2012-02-09 | Stem Centrx, Inc. | Novel effectors and methods of use |
| JP2013540694A (ja) | 2010-08-06 | 2013-11-07 | ウー３・フアルマ・ゲー・エム・ベー・ハー | Ｈｅｒ３結合剤の前立腺治療における使用 |
| JP2013535692A (ja) | 2010-08-10 | 2013-09-12 | アムジエン・インコーポレーテツド | 標的抗体に対する中和抗体検出用インビトロ二重機能標的結合アッセイ |
| WO2012021786A2 (en) | 2010-08-12 | 2012-02-16 | Theraclone Sciences, Inc. | Anti-hemagglutinin antibody compositions and methods of use thereof |
| EP2420250A1 (en) | 2010-08-13 | 2012-02-22 | Universitätsklinikum Münster | Anti-Syndecan-4 antibodies |
| JP2013537416A (ja) | 2010-08-13 | 2013-10-03 | メディミューン リミテッド | 変異型Ｆｃ領域を含むモノマーポリペプチド及び使用方法 |
| WO2012024255A2 (en) | 2010-08-16 | 2012-02-23 | Duke University | Camkk-beta as a target for treating cancer |
| WO2012022734A2 (en) | 2010-08-16 | 2012-02-23 | Medimmune Limited | Anti-icam-1 antibodies and methods of use |
| ES2716241T3 (es) | 2010-08-17 | 2019-06-11 | Univ Geneve | Isoformas de BARD1 en cáncer de pulmón y colorrectal y su uso |
| CA2802278A1 (en) | 2010-08-19 | 2012-02-23 | Veit Peter Grunert | An assay for measurement of antibodies binding to a therapeutic monoclonal antibody |
| EP2606067B1 (en) | 2010-08-19 | 2018-02-21 | Zoetis Belgium S.A. | Anti-ngf antibodies and their use |
| GB201014033D0 (en) | 2010-08-20 | 2010-10-06 | Ucb Pharma Sa | Biological products |
| UA114883C2 (uk) | 2010-08-20 | 2017-08-28 | Новартіс Аг | Антитіло до рецептора епідермального фактора росту-3 (her3) |
| PE20131376A1 (es) | 2010-08-27 | 2013-11-25 | Gilead Biologics Inc | Anticuerpos para metaloproteinasa-9 de matriz |
| CN103260646B (zh) | 2010-08-27 | 2016-01-13 | 施特姆森特克斯股份有限公司 | Notum蛋白调节剂和使用方法 |
| EP4226935A3 (en) | 2010-08-31 | 2023-09-06 | Theraclone Sciences, Inc. | Human immunodeficiency virus (hiv)-neutralizing antibodies |
| NZ608814A (en) | 2010-09-03 | 2015-06-26 | Stem Centrx Inc | Novel modulators and methods of use |
| SG188471A1 (en) | 2010-09-08 | 2013-04-30 | Yeda Res & Dev | An immunosuppressive drug combination for a stable and long term engraftment |
| US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
| WO2012035518A1 (en) | 2010-09-17 | 2012-03-22 | Compugen Ltd. | Compositions and methods for treatment of drug resistant multiple myeloma |
| KR20130110169A (ko) | 2010-09-22 | 2013-10-08 | 암젠 인크 | 담체 면역글로뷸린 및 이것의 용도 |
| ES2719624T3 (es) | 2010-09-23 | 2019-07-11 | Prec Biologics Inc | Peptidomiméticos de cáncer de colon y de páncreas |
| AU2011312205B2 (en) | 2010-10-05 | 2015-08-13 | Curis, Inc. | Mutant smoothened and methods of using the same |
| WO2012045703A1 (en) | 2010-10-05 | 2012-04-12 | Novartis Ag | Anti-il12rbeta1 antibodies and their use in treating autoimmune and inflammatory disorders |
| KR20140075639A (ko) | 2010-10-27 | 2014-06-19 | 더 리서치 파운데이션 포 더 스테이트 유니버시티 오브 뉴욕 | 암 치료법을 위한 e-카드헤린의 가용성 세포외 도메인의 표적화 조성물 및 관련 방법 |
| EP2632951B1 (en) | 2010-10-27 | 2017-08-02 | Amgen Inc. | Dkk1 antibodies and methods of use |
| WO2012056455A1 (en) | 2010-10-28 | 2012-05-03 | Yeda Research And Development Co. Ltd. | Methods of generating antibodies to metalloenzymes |
| TWI603738B (zh) | 2010-11-08 | 2017-11-01 | 建南德克公司 | 皮下投予抗－ｉｌ－６受體抗體 |
| US20140199682A1 (en) | 2010-11-17 | 2014-07-17 | Sea Lane Biotechnologies, Llc | Influenza neutralizing agents |
| US9072766B2 (en) | 2010-11-18 | 2015-07-07 | Beth Israel Deaconess Medical Center, Inc. | Methods of treating obesity by inhibiting nicotinamide N-methyl transferase (NNMT) |
| WO2012071436A1 (en) | 2010-11-24 | 2012-05-31 | Genentech, Inc. | Method of treating autoimmune inflammatory disorders using il-23r loss-of-function mutants |
| WO2012069466A1 (en) | 2010-11-24 | 2012-05-31 | Novartis Ag | Multispecific molecules |
| BR112013013083A2 (pt) | 2010-11-30 | 2016-12-13 | Genentech Inc | métodos para transportar um composto, para aumentar exposição do cns a um composto, para diminuir a depuração de um composto, para aumentar a retenção no cns de um composto, para otimizar a farmacocinética, para tratar um distúrbio neurológico em um mamífero, para desenvolver um anticorpo, anticorpo, fragmento de anticorpo, anticorpo multiespecífico e uso de um anticorpo |
| WO2012075333A2 (en) | 2010-12-02 | 2012-06-07 | Prometheus Laboratories Inc. | Her2delta16 peptides |
| SG10201601792UA (en) | 2010-12-08 | 2016-04-28 | Stemcentrx Inc | Novel modulators and methods of use |
| SI2654781T1 (sl) | 2010-12-21 | 2018-10-30 | Selexys Pharmaceuticals Corporation | Protitelesa proti P-selektinu in postopki za njihovo uporabo in identifikacijo |
| BR112013016235B1 (pt) | 2010-12-22 | 2020-03-31 | Cephalon Australia Pty Ltd | Anticorpo isolado, uso de um anticorpo, ácido nucleico, célula transformada e composição farmacêutica |
| SG191230A1 (en) | 2010-12-23 | 2013-07-31 | Nestec Sa | Drug selection for malignant cancer therapy using antibody-based arrays |
| CN105924519B (zh) | 2010-12-31 | 2019-08-23 | 生物蛋白有限公司 | 全面单克隆抗体产生 |
| WO2012092539A2 (en) | 2010-12-31 | 2012-07-05 | Takeda Pharmaceutical Company Limited | Antibodies to dll4 and uses thereof |
| US20120183548A1 (en) | 2011-01-14 | 2012-07-19 | Five Prime Therapeutics, Inc. | IL-27 Antagonists for Treating Inflammatory Diseases |
| DK2665833T3 (en) | 2011-01-17 | 2017-07-24 | Life Technologies Corp | WORKING PROCEDURE FOR DETECTING LIGANDS USING NUCLEIC ACIDS |
| WO2012099983A1 (en) | 2011-01-18 | 2012-07-26 | Amgen Inc. | Nav1.7 knockout mice and uses thereof |
| US9315566B2 (en) | 2011-01-24 | 2016-04-19 | National University Of Singapore | Pathogenic mycobacteria-derived mannose-capped lipoarabinomannan antigen binding proteins |
| AU2012212066A1 (en) | 2011-02-03 | 2013-08-15 | Alexion Pharmaceuticals, Inc. | Use of an anti-CD200 antibody for prolonging the survival of allografts |
| WO2012107589A1 (en) | 2011-02-11 | 2012-08-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment and prevention of hcv infections |
| CA2827301A1 (en) | 2011-02-14 | 2012-08-23 | Theraclone Sciences, Inc. | Compositions and methods for the therapy and diagnosis of influenza |
| WO2012110843A1 (en) | 2011-02-18 | 2012-08-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for promoting fibrinolysis and thrombolysis |
| SA112330278B1 (ar) | 2011-02-18 | 2015-10-09 | ستيم سينتركس، انك. | مواد ضابطة جديدة وطرق للاستخدام |
| WO2012114339A1 (en) | 2011-02-23 | 2012-08-30 | Rappaport Family Institute For Research In The Medical Sciences | High affinity molecules capable of binding a type a plexin receptor and uses of same |
| JP2014511182A (ja) | 2011-02-24 | 2014-05-15 | キアゲン ガイサーズバーグ アイエヌシー． | Ｈｐｖ核酸を検出するための材料及び方法 |
| DE14176593T1 (de) | 2011-02-25 | 2015-03-05 | Regeneron Pharmaceuticals, Inc. | ADAM6 Mäuse |
| WO2012118750A2 (en) | 2011-02-28 | 2012-09-07 | Genentech, Inc. | Biological markers and methods for predicting response to b-cell antagonists |
| EP2681242B1 (en) | 2011-03-01 | 2018-01-24 | Amgen Inc. | Sclerostin and dkk-1 bispecific binding agents |
| WO2012119989A2 (en) | 2011-03-04 | 2012-09-13 | Oryzon Genomics, S.A. | Methods and antibodies for the diagnosis and treatment of cancer |
| US9061006B2 (en) | 2011-03-08 | 2015-06-23 | Ramot At Tel-Aviv University Ltd. | Compositions and methods for diagnosing and treating phenylketonuria (PKU) |
| WO2012120130A1 (en) | 2011-03-09 | 2012-09-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods to characterize patients suffering from hemolysis |
| WO2012122512A1 (en) | 2011-03-10 | 2012-09-13 | Hco Antibody, Inc. | Recombinant production of mixtures of single chain antibodies |
| US20120315277A1 (en) | 2011-03-15 | 2012-12-13 | Theraclone Sciences, Inc. | Compositions and Methods for the Therapy and Diagnosis of Influenza |
| IN2013MN01438A (ja) | 2011-03-17 | 2015-06-12 | Univ Ramot | |
| US9555108B2 (en) | 2011-03-24 | 2017-01-31 | Texas Tech University System | TCR mimic antibodies as vascular targeting tools |
| WO2012135132A1 (en) | 2011-03-25 | 2012-10-04 | Baylor Research Institute | Compositions and methods to immunize against hepatitis c virus |
| CN109734807A (zh) | 2011-03-31 | 2019-05-10 | 豪夫迈·罗氏有限公司 | 施用β7整联蛋白拮抗剂的方法 |
| SG194111A1 (en) | 2011-04-07 | 2013-11-29 | Amgen Inc | Novel egfr binding proteins |
| EP2694554A1 (en) | 2011-04-08 | 2014-02-12 | Gilead Biologics, Inc. | Methods and compositions for normalization of tumor vasculature by inhibition of loxl2 |
| US9499610B2 (en) | 2011-04-08 | 2016-11-22 | H. Lundbeck A/S | Antibodies specific to pyroglutamated Aβ |
| US9150644B2 (en) | 2011-04-12 | 2015-10-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II |
| US9409987B2 (en) | 2011-04-15 | 2016-08-09 | Compugen Ltd | Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer |
| WO2012143524A2 (en) | 2011-04-20 | 2012-10-26 | Genmab A/S | Bispecific antibodies against her2 and cd3 |
| JP6177231B2 (ja) | 2011-04-20 | 2017-08-09 | ゲンマブ エー／エス | Ｈｅｒ２に対する二重特異性抗体 |
| WO2012149197A2 (en) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| JP6196613B2 (ja) | 2011-05-08 | 2017-09-13 | レゴケム バイオサイエンシズ， インク．Ｌｅｇｏｃｈｅｍ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ． | タンパク質−活性剤コンジュゲートおよびこれを調製するための方法 |
| JOP20200043A1 (ar) | 2011-05-10 | 2017-06-16 | Amgen Inc | طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول |
| WO2012155134A2 (en) | 2011-05-12 | 2012-11-15 | The Johns Hopkins University | Assay reagents for a neurogranin diagnostic kit |
| CN107936121B (zh) | 2011-05-16 | 2022-01-14 | 埃泰美德(香港)有限公司 | 多特异性fab融合蛋白及其使用方法 |
| JP6323718B2 (ja) | 2011-05-17 | 2018-05-16 | ザ ロックフェラー ユニバーシティー | ヒト免疫不全ウイルスを無毒化する抗体、およびその使用方法。 |
| AU2012258637B2 (en) | 2011-05-24 | 2017-07-20 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| CN103717619B (zh) | 2011-05-25 | 2018-11-13 | 因内特制药股份有限公司 | 治疗发炎及自体免疫疾病之抗-kir抗体 |
| WO2012163848A1 (en) | 2011-05-27 | 2012-12-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of crohn's disease |
| WO2012167173A1 (en) | 2011-06-02 | 2012-12-06 | The University Of Louisville Research Foundation, Inc. | Anti-nucleolin agent-conjugated nanoparticles |
| US8691231B2 (en) | 2011-06-03 | 2014-04-08 | Merrimack Pharmaceuticals, Inc. | Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies |
| KR102577578B1 (ko) | 2011-06-03 | 2023-09-11 | 조마 테크놀로지 리미티드 | Tgf-베타에 특이적인 항체 |
| EP2718327A1 (en) | 2011-06-06 | 2014-04-16 | Neotope Biosciences Limited | Mcam antagonists and methods of treatment |
| US9574002B2 (en) | 2011-06-06 | 2017-02-21 | Amgen Inc. | Human antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor |
| EP2720720B1 (en) | 2011-06-14 | 2018-02-28 | Yeda Research and Development Co. Ltd. | Combination therapy to prevent dcis formation and progression to breast cancer |
| WO2012172495A1 (en) | 2011-06-14 | 2012-12-20 | Novartis Ag | Compositions and methods for antibodies targeting tem8 |
| MX2013014847A (es) | 2011-06-17 | 2015-01-12 | Amgen Inc | Metodo para tratar o aminorar trastornos metabolicos udando clec-2. |
| EP2726503B1 (en) | 2011-06-30 | 2019-09-04 | Compugen Ltd. | Polypeptides and uses thereof for treatment of autoimmune disorders and infection |
| US9365651B2 (en) | 2011-07-01 | 2016-06-14 | Novartis Ag | Method for treating metabolic disorders by administration of an anti-ActRIIB antibody |
| JP2013040160A (ja) | 2011-07-01 | 2013-02-28 | Genentech Inc | 自己免疫疾患を治療するための抗ｃｄ８３アゴニスト抗体の使用 |
| EP2729496B8 (en) | 2011-07-06 | 2017-10-18 | Genmab A/S | Modulation of complement-dependent cytotoxicity through modifications of the c-terminus of antibody heavy chains |
| UA117901C2 (uk) | 2011-07-06 | 2018-10-25 | Ґенмаб Б.В. | Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування |
| EP2731623A1 (en) | 2011-07-14 | 2014-05-21 | Pfizer Inc | Treatment with anti-pcsk9 antibodies |
| EP2731970B1 (en) | 2011-07-15 | 2018-11-28 | MorphoSys AG | Antibodies that are cross-reactive for macrophage migration inhibitory factor (mif) and d-dopachrome tautomerase (d-dt) |
| KR20140048276A (ko) | 2011-07-15 | 2014-04-23 | 온코메드 파마슈티칼스, 인크. | Rspo 결합제 및 이의 용도 |
| US9156911B2 (en) | 2011-07-18 | 2015-10-13 | Amgen Inc. | Apelin antigen-binding proteins and uses thereof |
| US20130022551A1 (en) | 2011-07-22 | 2013-01-24 | Trustees Of Boston University | DEspR ANTAGONISTS AND AGONISTS AS THERAPEUTICS |
| US9120858B2 (en) | 2011-07-22 | 2015-09-01 | The Research Foundation Of State University Of New York | Antibodies to the B12-transcobalamin receptor |
| WO2013015821A1 (en) | 2011-07-22 | 2013-01-31 | The Research Foundation Of State University Of New York | Antibodies to the b12-transcobalamin receptor |
| US9493549B2 (en) | 2011-07-25 | 2016-11-15 | The Rockefeller University | Antibodies directed toward the HIV-1 GP120 CD4 binding site with increased potency and breadth |
| US9890207B2 (en) | 2011-07-25 | 2018-02-13 | California Institute Of Technology | Highly active agonistic CD4 binding site anti-HIV antibodies (HAADS) comprising modified CDRH2 regions that improve contact with GP120 |
| EP2737083A1 (en) | 2011-07-27 | 2014-06-04 | INSERM (Institut National de la Santé et de la Recherche Scientifique) | Methods for diagnosing and treating myhre syndrome |
| PE20141693A1 (es) | 2011-08-01 | 2014-11-24 | Genentech Inc | Metodos para tratar el cancer por el uso de antagonistas de union al eje pd-1e inhibidores de mek |
| CA2844012C (en) | 2011-08-04 | 2021-03-16 | Yeda Research And Development Co. Ltd. | Micro-rnas and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions |
| PL3572517T3 (pl) | 2011-08-05 | 2021-10-04 | Regeneron Pharmaceuticals, Inc. | Myszy z humanizowanym uniwersalnym łańcuchem lekkim |
| US20140296490A1 (en) | 2011-08-10 | 2014-10-02 | Laboratoire Français Du Fractionnement Et Des Biotechnologies | Highly galactosylated antibodies |
| US9458447B2 (en) | 2011-08-12 | 2016-10-04 | Oncotherapy Science, Inc. | MPHOSPH1 peptides and vaccines including the same |
| US20140271680A1 (en) | 2011-08-12 | 2014-09-18 | Universite Paris-Est Creteil Val De Marne | Methods and pharmaceutical compositions for treatment of pulmonary hypertension |
| WO2013025479A1 (en) | 2011-08-16 | 2013-02-21 | Emory University | Jaml specific binding agents, antibodies, and uses related thereto |
| BR112014003599A2 (pt) | 2011-08-17 | 2018-04-17 | Genentech Inc | método de inibição da angiogênese tumoral, método de supressão do crescimento tumoral e método de tratamento de tumor |
| US8822651B2 (en) | 2011-08-30 | 2014-09-02 | Theraclone Sciences, Inc. | Human rhinovirus (HRV) antibodies |
| US20130058947A1 (en) | 2011-09-02 | 2013-03-07 | Stem Centrx, Inc | Novel Modulators and Methods of Use |
| JP6186575B2 (ja) | 2011-09-02 | 2017-08-30 | ダイアテック ホールディングス， インコーポレイテッドＤｉａＴｅｃｈ Ｈｏｌｄｉｎｇｓ， Ｉｎｃ． | 治療有効性を判定するためのシグナル経路タンパク質のプロファイリング |
| EP3839049A3 (en) | 2011-09-19 | 2021-10-20 | Kymab Limited | Antibodies, variable domains & chains tailored for human use |
| ES2716723T3 (es) | 2011-09-20 | 2019-06-14 | Univ North Carolina Chapel Hill | Regulación de los canales de sodio por las proteínas PLUNC |
| EP3485903B1 (en) | 2011-09-23 | 2022-11-16 | Mereo BioPharma 5, Inc. | Vegf/dll4 binding agents and uses thereof |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| BR112014007487A2 (pt) | 2011-09-30 | 2017-04-04 | Dana Farber Cancer Inst Inc | peptídeos terapêuticos |
| SG11201401287SA (en) | 2011-10-05 | 2014-05-29 | Genentech Inc | Methods of treating liver conditions using notch2 antagonists |
| WO2013050441A1 (en) | 2011-10-05 | 2013-04-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for inhibiting or preventing platelet aggregation |
| WO2013054320A1 (en) | 2011-10-11 | 2013-04-18 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam) |
| CN107080843A (zh) | 2011-10-13 | 2017-08-22 | 爱尔皮奥治疗有限公司 | 眼病的治疗 |
| CA2850830A1 (en) | 2011-10-13 | 2013-04-18 | Aerpio Therapeutics, Inc. | Methods for treating vascular leak syndrome and cancer |
| AU2012322618A1 (en) | 2011-10-14 | 2014-05-29 | Genentech, Inc. | Anti-HtrA1 antibodies and methods of use |
| EP3653222A1 (en) | 2011-10-14 | 2020-05-20 | Novartis AG | Antibodies and methods for wnt pathway-related diseases |
| LT3216871T (lt) | 2011-10-17 | 2022-03-25 | Regeneron Pharmaceuticals, Inc. | Pelės, turinčios apribotą imunoglobulino sunkiąją grandinę |
| US20140248284A1 (en) | 2011-10-20 | 2014-09-04 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for the detection and the treatment of cardiac remodeling |
| EP2771694A4 (en) | 2011-10-26 | 2015-08-05 | Novartis Tiergesundheit Ag | MONOCLONAL ANTIBODIES AND METHOD FOR THEIR USE |
| US9145559B2 (en) | 2011-10-27 | 2015-09-29 | Yeda Research And Development Co. Ltd. | Methods of treating cancer |
| SG10201805291TA (en) | 2011-10-27 | 2018-08-30 | Genmab As | Production of heterodimeric proteins |
| JP6238900B2 (ja) | 2011-10-28 | 2017-11-29 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｎａｅ阻害物質に対する応答のバイオマーカー |
| CA3122778A1 (en) | 2011-10-28 | 2013-05-02 | Oncotherapy Science, Inc. | Topk peptides and vaccines including the same |
| DK3091029T3 (da) | 2011-10-31 | 2023-01-30 | Hoffmann La Roche | Anti-IL13-antistofformuleringer |
| EP2773664A1 (en) | 2011-11-01 | 2014-09-10 | Bionomics, Inc. | Anti-gpr49 antibodies |
| JP2014533247A (ja) | 2011-11-01 | 2014-12-11 | バイオノミクス インコーポレイテッド | 抗体および癌を治療する方法 |
| AU2012332588B2 (en) | 2011-11-01 | 2017-09-07 | Bionomics, Inc. | Methods of blocking cancer stem cell growth |
| WO2013067060A1 (en) | 2011-11-01 | 2013-05-10 | Bionomics, Inc. | Anti-gpr49 antibodies |
| US20140301977A1 (en) | 2011-11-02 | 2014-10-09 | Genentech, Inc. | Overload and elute chromatography |
| US9487577B2 (en) | 2011-11-02 | 2016-11-08 | University Of Rochester | Anti-glucosaminidase passive immunization for Staphylococcus aureus infections |
| BR112014011115A2 (pt) | 2011-11-08 | 2017-06-13 | Pfizer | métodos para tratamento de distúrbios inflamatórios usando anticorpos anti-m-csf |
| WO2013071233A1 (en) | 2011-11-10 | 2013-05-16 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for detecting infectious agents and a novel virus detected thereby |
| RU2014116406A (ru) | 2011-11-11 | 2015-12-20 | Ринат Ньюросайенс Корп. | Антитела, специфичные к trop-2, и их применения |
| PT2776466T (pt) | 2011-11-11 | 2017-11-30 | Ucb Biopharma Sprl | Anticorpos de ligação a albumina e seus fragmentos de ligação |
| WO2013071163A2 (en) | 2011-11-11 | 2013-05-16 | Millennium Pharamaceuticals, Inc. | Biomarkers of response to proteasome inhibitors |
| WO2013071142A1 (en) | 2011-11-11 | 2013-05-16 | Millennium Pharmaceuticals, Inc. | Biomarkers of response to proteasome inhibitors |
| CA2855746A1 (en) | 2011-11-16 | 2013-05-23 | John Stephen HILL | Methods of treating epidermal growth factor deletion mutant viii related disorders |
| US20140328864A1 (en) | 2011-11-22 | 2014-11-06 | Inserm (Institut National De La Sente Et De La Recherche Medicale) | Methods and pharmaceutical compositions for reducing airway hyperresponse |
| EP3608340A1 (en) | 2011-11-23 | 2020-02-12 | Medlmmune, LLC | Binding molecules specific for her3 and uses thereof |
| JP2015501639A (ja) | 2011-11-23 | 2015-01-19 | アイジェニカ バイオセラピューティクス インコーポレイテッド | 抗ｃｄ９８抗体およびその使用方法 |
| CA2856895C (en) | 2011-11-28 | 2021-10-26 | Merck Patent Gmbh | Anti-pd-l1 antibodies and uses thereof |
| US9381229B2 (en) | 2011-11-28 | 2016-07-05 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Pharmaceutical composition for use in the treatment of dysfunction associated with aging |
| US20140348848A1 (en) | 2011-12-02 | 2014-11-27 | Dhananjay Kaul | Anti-il-1beta (interleukin-1beta) antibody-based prophylactic therapy to prevent complications leading to vaso-occlusion in sickle cell disease |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| UY34487A (es) | 2011-12-05 | 2013-07-31 | Novartis Ag | Anticuerpos para receptor de factor de crecimiento epidérmico 3(her3) |
| BR112014013568A2 (pt) | 2011-12-05 | 2017-06-13 | Novartis Ag | anticorpos para o receptor do fator de crescimento epidermal 3 (her3) direcionados para o domínio ii do her3 |
| JP6635655B2 (ja) | 2011-12-08 | 2020-01-29 | アムジエン・インコーポレーテツド | ヒトｌｃａｔ抗原結合タンパク質および治療法におけるそれらの使用 |
| EP3050900A1 (en) | 2011-12-19 | 2016-08-03 | Xoma (Us) Llc | Methods for treating acne |
| LT2793567T (lt) | 2011-12-20 | 2019-04-10 | Regeneron Pharmaceuticals, Inc. | Humanizuotos lengvosios grandinės pelės |
| GB201121891D0 (en) | 2011-12-20 | 2012-02-01 | Bakhiet Abdelmoiz | Applications of an immune system-released activating agent (ISRAA) |
| SG11201403416TA (en) | 2011-12-21 | 2014-07-30 | Novartis Ag | Compositions and methods for antibodies targeting factor p |
| WO2013101771A2 (en) | 2011-12-30 | 2013-07-04 | Genentech, Inc. | Compositions and method for treating autoimmune diseases |
| CA2862979A1 (en) | 2012-01-09 | 2013-07-18 | The Scripps Research Institute | Humanized antibodies with ultralong cdr3s |
| WO2013106485A2 (en) | 2012-01-09 | 2013-07-18 | The Scripps Research Institute | Ultralong complementarity determining regions and uses thereof |
| WO2013106765A1 (en) | 2012-01-13 | 2013-07-18 | Genentech, Inc. | Biological markers for identifying patients for treatment with vegf antagonists |
| TW201334789A (zh) | 2012-01-31 | 2013-09-01 | Genentech Inc | 抗ｉｇｅ抗體及其使用方法 |
| CN104185681A (zh) | 2012-02-01 | 2014-12-03 | 卡姆普根有限公司 | C1orf32抗体及其用于治疗癌症的用途 |
| US9045541B2 (en) | 2012-02-06 | 2015-06-02 | Inhibrx Llc | CD47 antibodies and methods of use thereof |
| US10047345B2 (en) | 2012-02-13 | 2018-08-14 | Gamida-Cell Ltd. | Culturing of mesenchymal stem cells with FGF4 and nicotinamide |
| GB201203051D0 (en) | 2012-02-22 | 2012-04-04 | Ucb Pharma Sa | Biological products |
| CA2864702A1 (en) | 2012-02-22 | 2013-08-29 | Amgen Inc. | Autologous mammalian models derived from induced pluripotent stem cells and related methods |
| GB201203071D0 (en) | 2012-02-22 | 2012-04-04 | Ucb Pharma Sa | Biological products |
| EP2817338B1 (en) | 2012-02-24 | 2017-07-26 | AbbVie Stemcentrx LLC | Dll3 modulators and methods of use |
| NZ629178A (en) | 2012-02-29 | 2016-09-30 | Gilead Biologics Inc | Antibodies to matrix metalloproteinase 9 |
| BR112014021477A2 (pt) | 2012-02-29 | 2018-06-12 | Gilead Sciences Inc | anticorpos para metaloproteinase de matriz 9 |
| FR2987627B1 (fr) | 2012-03-05 | 2016-03-18 | Splicos | Utilisation de rbm39 comme biomarqueur |
| WO2013132495A1 (en) | 2012-03-07 | 2013-09-12 | Yeda Research And Development Co. Ltd. | Compositions for inhibition of quiescin sulfhydryl oxidase (qsox1) and uses of same |
| LT3348140T (lt) | 2012-03-16 | 2021-01-25 | Regeneron Pharmaceuticals, Inc. | Histidinu pakeisti lengvosios grandinės antikūnai ir genetiškai modifikuoti graužikai, išvesti jų gamybai |
| CA2865645A1 (en) | 2012-03-16 | 2013-09-19 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing immunoglobulin sequences ph-sensitive for antigen building |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| MY173376A (en) | 2012-03-16 | 2020-01-21 | Regeneron Pharma | Mice that produce antigen?binding proteins with ph?dependent binding characteristics |
| EP2828280B1 (en) | 2012-03-22 | 2018-05-02 | Ramot at Tel-Aviv University Ltd. | Plif multimeric peptides and uses thereof |
| WO2013139956A1 (en) | 2012-03-22 | 2013-09-26 | Thrombogenics Nv | Antibodies abrogating cell binding to lactadherin |
| WO2013148232A1 (en) | 2012-03-27 | 2013-10-03 | Genentech, Inc. | Methods of prognosing, diagnosing and treating idiopathic pulmonary fibrosis |
| CA2865082A1 (en) | 2012-03-27 | 2013-10-03 | Genentech, Inc. | Diagnosis and treatments relating to her3 inhibitors |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| WO2013149111A2 (en) | 2012-03-29 | 2013-10-03 | Novimmune S.A. | Anti-tlr4 antibodies and uses thereof |
| CN104271157A (zh) | 2012-03-30 | 2015-01-07 | 霍夫曼-拉罗奇有限公司 | 用于治疗癌症的诊断方法和组合物 |
| ES2702278T3 (es) | 2012-04-01 | 2019-02-28 | Technion Res & Dev Foundation | Péptidos de inductor de metaloproteinasa de matriz extracelular (emmprin) y anticuerpos de unión |
| EP2836514A4 (en) | 2012-04-13 | 2015-12-30 | Childrens Medical Center | TIKI INHIBITORS |
| US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
| WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| JP2015515487A (ja) | 2012-04-24 | 2015-05-28 | スロンボジェニックス エヌ．ブイ． | 抗ｐｄｇｆ−ｃ抗体 |
| KR20180137614A (ko) | 2012-04-27 | 2018-12-27 | 노보 노르디스크 에이/에스 | 사람 cd30 리간드 항원 결합 단백질 |
| EA039663B1 (ru) | 2012-05-03 | 2022-02-24 | Амген Инк. | Применение антитела против pcsk9 для снижения сывороточного холестерина лпнп и лечения связанных с холестерином расстройств |
| WO2013165590A1 (en) | 2012-05-03 | 2013-11-07 | Fibrogen, Inc. | Methods for treating idiopathic pulmonary fibrosis |
| EP2844674A1 (en) | 2012-05-04 | 2015-03-11 | Dana-Farber Cancer Institute, Inc. | Affinity matured anti-ccr4 humanized monoclonal antibodies and methods of use |
| KR20200011616A (ko) | 2012-05-11 | 2020-02-03 | 파이브 프라임 테라퓨틱스, 인크. | 콜로니 자극 인자 1 수용체(csf1r)에 결속하는 항체들에 의한 질병 상태의 치료 방법 |
| NZ701573A (en) | 2012-05-17 | 2017-04-28 | Extend Biosciences Inc | Carriers for improved drug delivery |
| WO2013173266A1 (en) | 2012-05-17 | 2013-11-21 | The Johns Hopkins University | Methods for identifying patterns of ifn induced expression and use in diagnosis, monitoring and therapy |
| AU2013262611B2 (en) | 2012-05-18 | 2018-03-01 | Genentech, Inc. | High-concentration monoclonal antibody formulations |
| SG11201407669QA (en) | 2012-05-21 | 2014-12-30 | Genentech Inc | Methods for improving safety of blood-brain barrier transport |
| JP2015520373A (ja) | 2012-05-22 | 2015-07-16 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 巣状分節性糸球体硬化症を診断及び処置するための方法 |
| US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
| KR20200079568A (ko) | 2012-05-31 | 2020-07-03 | 제넨테크, 인크. | Pd-l1 축 결합 길항제 및 vegf 길항제를 사용하여 암을 치료하는 방법 |
| CA2875783C (en) | 2012-06-06 | 2018-12-11 | Zoetis Llc | Caninized anti-ngf antibodies and methods thereof |
| WO2013184900A2 (en) | 2012-06-06 | 2013-12-12 | Sanofi Pasteur Biologics, Llc | Immunogenic compositions and related methods |
| CA2875980A1 (en) | 2012-06-06 | 2013-12-12 | Oncomed Pharmaceuticals, Inc. | Binding agents that modulate the hippo pathway and uses thereof |
| EP2859017B1 (en) | 2012-06-08 | 2019-02-20 | Sutro Biopharma, Inc. | Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
| AU2013274347B2 (en) | 2012-06-11 | 2018-03-08 | Amgen Inc. | Dual receptor antagonistic antigen-binding proteins and uses thereof |
| EP2858487B1 (en) | 2012-06-12 | 2019-10-23 | Regeneron Pharmaceuticals, Inc. | Humanized non-human animals with restricted immunoglobulin heavy chain loci |
| KR20150023729A (ko) | 2012-06-14 | 2015-03-05 | 암브룩스, 인코포레이티드 | 핵 수용체 리간드 폴리펩티드에 접합된 항-psma 항체 |
| US9879068B2 (en) | 2012-06-21 | 2018-01-30 | California Institute Of Technology | Antibodies targeting HIV escape mutants |
| BR112014031689A2 (pt) | 2012-06-22 | 2017-07-25 | Cytomx Therapeutics Inc | anticorpos reativos cruzados anti-jagged 1/jagged 2, anticorpos anti-jagged ativáveis e métodos de uso deles |
| US9890215B2 (en) | 2012-06-22 | 2018-02-13 | King's College London | Vista modulators for diagnosis and treatment of cancer |
| BR112014032276A2 (pt) | 2012-06-22 | 2017-11-28 | King S College London | construtos de vista-ig e o uso de vista-ig para o tratamento de distúrbios autoimunes, alérgicos e inflamatórios |
| EP2867674B1 (en) | 2012-06-28 | 2018-10-10 | UCB Biopharma SPRL | A method for identifying compounds of therapeutic interest |
| AR091649A1 (es) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
| JP6514103B2 (ja) | 2012-07-06 | 2019-05-15 | ゲンマブ ビー．ブイ． | 三重変異を有する二量体タンパク質 |
| EP3632462A1 (en) | 2012-07-06 | 2020-04-08 | Genmab B.V. | Dimeric protein with triple mutations |
| JP6255594B2 (ja) | 2012-07-10 | 2018-01-10 | オンコセラピー・サイエンス株式会社 | Ｔｈ１細胞のＬＹ６Ｋエピトープペプチドおよびこれを含有するワクチン |
| US9561265B2 (en) | 2012-07-10 | 2017-02-07 | Oncotherapy Science, Inc. | KIF20A epitope peptides for TH1 cells and vaccines containing the same |
| MX2015000565A (es) | 2012-07-13 | 2015-04-10 | Oncomed Pharm Inc | Agentes de union de proteina de r-espondina humana (rspo3) y usos de los mismos. |
| US20150184155A1 (en) | 2012-07-18 | 2015-07-02 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for preventing and treating chronic kidney disease (ckd) |
| DK2877494T3 (da) | 2012-07-23 | 2020-09-21 | La Jolla Inst Allergy & Immunology | PTPRS og proteoglycaner i autoimmun sygdom |
| US9567569B2 (en) | 2012-07-23 | 2017-02-14 | Gamida Cell Ltd. | Methods of culturing and expanding mesenchymal stem cells |
| US9175266B2 (en) | 2012-07-23 | 2015-11-03 | Gamida Cell Ltd. | Enhancement of natural killer (NK) cell proliferation and activity |
| WO2014018375A1 (en) | 2012-07-23 | 2014-01-30 | Xenon Pharmaceuticals Inc. | Cyp8b1 and uses thereof in therapeutic and diagnostic methods |
| US9297806B2 (en) | 2012-08-01 | 2016-03-29 | The Johns Hopkins University | 5-hydroxymethylcytosine in human cancer |
| FR2994390B1 (fr) | 2012-08-10 | 2014-08-15 | Adocia | Procede d'abaissement de la viscosite de solutions de proteines a concentration elevee |
| EP2885311B1 (en) | 2012-08-18 | 2020-01-01 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
| JP6211084B2 (ja) | 2012-08-21 | 2017-10-11 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | ベンゾシクロオクチン化合物およびその使用 |
| DK2890710T3 (da) | 2012-08-28 | 2017-11-20 | Novartis Ag | Fremgangsmåder til rensning af antistoffer under anvendelse af aliphatiske alkoholer |
| AU2013307406B2 (en) | 2012-08-29 | 2018-03-15 | F. Hoffmann-La Roche Ag | Blood brain barrier shuttle |
| US20140079699A1 (en) | 2012-08-31 | 2014-03-20 | Five Prime Therapeutics, Inc. | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
| NZ726258A (en) | 2012-08-31 | 2019-07-26 | Immunogen Inc | Antibodies and uses thereof to detect folate receptor 1 |
| CA2883569A1 (en) | 2012-08-31 | 2014-03-06 | University Of Virginia Patent Foundation | Target peptides for immunotherapy and diagnostics |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| CA2883272A1 (en) | 2012-09-02 | 2014-03-06 | Abbvie Inc. | Methods to control protein heterogeneity |
| US10682399B2 (en) | 2012-09-05 | 2020-06-16 | The University Of Birmingham | Target peptides for colorectal cancer therapy and diagnostics |
| CN105246507B (zh) | 2012-09-07 | 2019-01-25 | 达特茅斯大学理事会 | 用于诊断和治疗癌症的vista调节剂 |
| JOP20200308A1 (ar) | 2012-09-07 | 2017-06-16 | Novartis Ag | جزيئات إرتباط il-18 |
| TW201922795A (zh) | 2012-09-10 | 2019-06-16 | 愛爾蘭商尼歐托普生物科學公司 | 抗ｍｃａｍ抗體及相關使用方法 |
| WO2014041544A1 (en) | 2012-09-12 | 2014-03-20 | Ramot At Tel-Aviv University Ltd. | Immunoparticles and methods of generating and using same |
| US9303071B2 (en) | 2012-09-17 | 2016-04-05 | Novartis Tiergesundheit Ag | Salmonid alphavirus and uses thereof |
| AU2013317985B2 (en) | 2012-09-19 | 2019-06-13 | Dana-Farber Cancer Institute, Inc. | Dynamic BH3 profiling |
| JP6486826B2 (ja) | 2012-10-01 | 2019-03-20 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 阻害剤に対する応答を予測するためのバイオマーカーおよび方法、ならびにそれらの使用 |
| CN107892719B (zh) | 2012-10-04 | 2022-01-14 | 达纳－法伯癌症研究所公司 | 人单克隆抗-pd-l1抗体和使用方法 |
| CN104870056A (zh) | 2012-10-05 | 2015-08-26 | 弗·哈夫曼-拉罗切有限公司 | 用于诊断和治疗炎性肠病的方法 |
| ES2776029T3 (es) | 2012-10-08 | 2020-07-28 | St Jude Childrens Res Hospital | Terapias basadas en el control de la estabilidad y función de las células T reguladoras por medio de un eje neuropilina-1:semaforina |
| WO2014059028A1 (en) | 2012-10-09 | 2014-04-17 | Igenica, Inc. | Anti-c16orf54 antibodies and methods of use thereof |
| US11105809B2 (en) | 2012-10-09 | 2021-08-31 | Ramot At Tel-Aviv University Ltd. | Methods and kits for predicting prognosis of cancer using soluble mortalin in blood |
| EP2908912B1 (en) | 2012-10-18 | 2020-08-05 | The Rockefeller University | Broadly-neutralizing anti-hiv antibodies |
| WO2014064682A1 (en) | 2012-10-24 | 2014-05-01 | Yeda Research And Development Co. Ltd. | Combinations of epidermal growth factor receptor targeting antibodies for treating cancer |
| US20150246118A1 (en) | 2012-10-26 | 2015-09-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Lyve-1 antagonists for preventing or treating a pathological condition associated with lymphangiogenesis |
| AU2013334493B2 (en) | 2012-10-26 | 2018-11-29 | The University Of Queensland | Use of endocytosis inhibitors and antibodies for cancer therapy |
| EP2912060B1 (en) | 2012-10-29 | 2019-12-25 | The University of North Carolina at Chapel Hill | Compositions and methods for inhibiting pathogen infection |
| JP6371294B2 (ja) | 2012-10-31 | 2018-08-08 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Ｄｌｌ４アンタゴニストによる処置の方法およびモニタリング |
| EP2914618B1 (en) | 2012-11-02 | 2017-07-26 | Novartis Tiergesundheit AG | Flavivirus associated with theiler's disease |
| EA201590880A1 (ru) | 2012-11-05 | 2015-09-30 | Джензим Корпорейшн | Композиции и способы лечения протеинопатий |
| SG10201608703SA (en) | 2012-11-08 | 2016-12-29 | Eleven Biotherapeutics Inc | Il-6 antagonists and uses thereof |
| WO2014072416A1 (en) | 2012-11-08 | 2014-05-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of bone metastases |
| AR093445A1 (es) | 2012-11-14 | 2015-06-10 | Regeneron Pharma | Metodos para tratar el cancer de ovario con antagonistas de dll4 |
| WO2014078729A1 (en) | 2012-11-15 | 2014-05-22 | Genentech, Inc. | IONIC STRENGTH-MEDIATED pH GRADIENT ION EXCHANGE CHROMATOGRAPHY |
| JP2016502536A (ja) | 2012-11-29 | 2016-01-28 | イェダ リサーチ アンド デベロップメント カンパニー リミテッド | 腫瘍転移を防止し、がんを処置および予後診断し、推定転移阻害剤である薬剤を同定する方法 |
| WO2014084859A1 (en) | 2012-11-30 | 2014-06-05 | Novartis Ag | Molecules and methods for modulating tmem16a activities |
| US10407503B2 (en) | 2012-11-30 | 2019-09-10 | The Regents Of The University Of California | Fully human antibodies and fragments recognizing human c-Met |
| ES2784631T3 (es) | 2012-12-03 | 2020-09-29 | Novimmune Sa | Anticuerpos anti-CD47 y métodos de uso de los mismos |
| EA033643B1 (ru) | 2012-12-05 | 2019-11-12 | Novartis Ag | Антитело к эритропоэтину или его антигенсвязывающий фрагмент |
| EP2931293B1 (en) | 2012-12-12 | 2019-02-20 | University Of Virginia Patent Foundation | Compositions and methods for regulating erythropoiesis |
| US20160000893A1 (en) | 2012-12-13 | 2016-01-07 | University Of Virginia Patent Foundation | Target peptides for ovarian cancer therapy and diagnostics |
| JP6461808B2 (ja) | 2012-12-17 | 2019-01-30 | ラボラトワール フランセ ドゥ フラクションマン エ デ バイオテクノロジーズＬａｂｏｒａｔｏｉｒｅ Ｆｒａｎｃａｉｓ Ｄｕ Ｆｒａｃｔｉｏｎｎｅｍｅｎｔ Ｅｔ Ｄｅｓ Ｂｉｏｔｅｃｈｎｏｌｏｇｉｅｓ | 炎症および細菌感染症処置におけるモノクローナル抗体の使用 |
| EA201591176A1 (ru) | 2012-12-18 | 2016-02-29 | Новартис Аг | Композиции и способы с использованием пептидной метки, связывающейся с гиалуронаном |
| WO2014100602A1 (en) | 2012-12-20 | 2014-06-26 | Hospital For Special Surgery | Treatment of egf-receptor dependent pathologies |
| AR094280A1 (es) | 2012-12-21 | 2015-07-22 | Bioalliance Cv | Enlazantes hidrofilicos auto-inmolantes y conjugados de los mismos |
| GB201223276D0 (en) | 2012-12-21 | 2013-02-06 | Ucb Pharma Sa | Antibodies and methods of producing same |
| EP2938633B1 (en) | 2012-12-28 | 2018-02-07 | Precision Biologics, Inc. | Humanized monoclonal antibodies and methods of use for the diagnosis and treatment of colon and pancreas cancer |
| WO2014108854A1 (en) | 2013-01-09 | 2014-07-17 | Fusimab Ltd. | Monospecific anti-hgf and anti-ang2 antibodies and bispecific anti-hgf/anti-ang2 antibodies |
| MX2015008740A (es) | 2013-01-10 | 2015-10-26 | Genmab Bv | Variantes de regiones fc de igg1 de humano y usos de las mismas. |
| WO2014114801A1 (en) | 2013-01-25 | 2014-07-31 | Amgen Inc. | Antibodies targeting cdh19 for melanoma |
| JO3519B1 (ar) | 2013-01-25 | 2020-07-05 | Amgen Inc | تركيبات أجسام مضادة لأجل cdh19 و cd3 |
| WO2014118317A1 (en) | 2013-02-01 | 2014-08-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting and preventing metastasis in triple negative breast cancers |
| KR102170196B1 (ko) | 2013-02-06 | 2020-10-26 | 인히브릭스, 인크. | 비-혈소판 및 비-적혈구 세포 격감성 cd47 항체 및 이를 이용하는 방법 |
| CU24300B1 (es) | 2013-02-08 | 2017-12-08 | Novartis Ag | Anticuerpos anti-il-17a útiles en el tratamiento de trastornos autoinmunes e inflamatorios |
| EP2956485A2 (en) | 2013-02-13 | 2015-12-23 | Laboratoire Français du Fractionnement et des Biotechnologies | Highly galactosylated anti-her2 antibodies and uses thereof |
| AU2014217569B2 (en) | 2013-02-13 | 2018-10-25 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Cetuximab with modified glycosylation and uses thereof |
| AR094778A1 (es) | 2013-02-13 | 2015-08-26 | Laboratoire Français Du Fractionnement Et Des Biotechnologies | Proteínas con glicosilación modificada y métodos para producirlas |
| EP2956480B1 (en) | 2013-02-13 | 2019-09-04 | Laboratoire Français du Fractionnement et des Biotechnologies | Highly galactosylated anti-tnf-alpha antibodies and uses thereof |
| RS60026B1 (sr) | 2013-02-18 | 2020-04-30 | Vegenics Pty Ltd | Molekuli koji vezuju ligande i njihove upotrebe |
| EP2767549A1 (en) | 2013-02-19 | 2014-08-20 | Adienne S.A. | Anti-CD26 antibodies and uses thereof |
| HUE039214T2 (hu) | 2013-02-20 | 2018-12-28 | Regeneron Pharma | Módosított szekvenciájú immunglobulin-nehézlánccal rendelkezõ, nem humán élõlények |
| WO2014130879A2 (en) | 2013-02-22 | 2014-08-28 | Stem Centrx, Inc. | Novel antibody conjugates and uses thereof |
| CA2901126C (en) | 2013-02-25 | 2022-01-25 | Genentech, Inc. | Methods and compositions for detecting and treating drug resistant akt mutant |
| TWI658049B (zh) | 2013-03-12 | 2019-05-01 | 腫瘤療法 科學股份有限公司 | Ｋｎｔｃ２胜肽及含此胜肽之疫苗 |
| EP2830651A4 (en) | 2013-03-12 | 2015-09-02 | Abbvie Inc | HUMAN ANTIBODIES THAT BIND TNF-ALPHA AND PREPARATION METHODS |
| JOP20140087B1 (ar) | 2013-03-13 | 2021-08-17 | Amgen Inc | بروتينات مخصصة ل baff و b7rp1 وإستخداماتها |
| AR095398A1 (es) | 2013-03-13 | 2015-10-14 | Genentech Inc | Formulaciones con oxidación reducida |
| EP2968466B1 (en) | 2013-03-13 | 2018-07-25 | F.Hoffmann-La Roche Ag | Formulations with reduced oxidation |
| US10550201B2 (en) | 2013-03-13 | 2020-02-04 | Bioventures, Llc | Antibody-nanoparticle conjugates for the treatment of drug abuse |
| WO2014160490A1 (en) | 2013-03-13 | 2014-10-02 | Genetech, Inc. | Antibody formulations |
| AR095399A1 (es) | 2013-03-13 | 2015-10-14 | Genentech Inc | Formulaciones con oxidación reducida, método |
| CA2904169C (en) | 2013-03-13 | 2021-12-07 | Genentech, Inc. | Formulations with reduced oxidation |
| US9023353B2 (en) | 2013-03-13 | 2015-05-05 | The Board Of Trustees Of The University Of Arkansas | Anti-(+)—methamphetamine monoclonal antibodies |
| US9458246B2 (en) | 2013-03-13 | 2016-10-04 | Amgen Inc. | Proteins specific for BAFF and B7RP1 |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| WO2014159764A1 (en) | 2013-03-14 | 2014-10-02 | Amgen Inc. | Chrdl-1 antigen binding proteins and methods of treatment |
| JP2016514130A (ja) | 2013-03-14 | 2016-05-19 | ノバルティス アーゲー | Ｎｏｔｃｈ３に対する抗体 |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| SG11201507563SA (en) | 2013-03-14 | 2015-10-29 | Parkash Gill | Cancer treatment using antibodies that bind cell surface grp78 |
| WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
| ES2829376T3 (es) | 2013-03-14 | 2021-05-31 | Univ Erasmus Med Ct Rotterdam | Mamífero no humano transgénico para la producción de anticuerpos |
| WO2014159242A1 (en) | 2013-03-14 | 2014-10-02 | Novartis Ag | Notch 3 mutants and uses thereof |
| AU2014228502A1 (en) | 2013-03-15 | 2015-08-20 | Dana-Farber Cancer Institute, Inc. | Therapeutic peptides |
| US9850297B2 (en) | 2013-03-15 | 2017-12-26 | Amgen Inc. | Secreted frizzle-related protein 5 (SFRP5) binding proteins |
| WO2014145091A1 (en) | 2013-03-15 | 2014-09-18 | Genentech, Inc. | Cell culture media and methods of antibody production |
| JP6566933B2 (ja) | 2013-03-15 | 2019-08-28 | サッター ベイ ホスピタルズ | ガンを治療するための療法のための標的として使用するためのｆａｌｚ |
| EP2970446A1 (en) | 2013-03-15 | 2016-01-20 | Amgen Research (Munich) GmbH | Antibody constructs for influenza m2 and cd3 |
| AP2015008732A0 (en) | 2013-03-15 | 2015-09-30 | Amgen Inc | Human pac1 antibodies |
| SI2970449T1 (sl) | 2013-03-15 | 2019-11-29 | Amgen Res Munich Gmbh | Enoverižne vezavne molekule, ki vsebujejo N-terminalni ABP |
| CA2901358C (en) | 2013-03-15 | 2022-07-26 | Dana-Farber Cancer Institute, Inc. | Flavivirus neutralizing antibodies and methods of use thereof |
| US20140283157A1 (en) | 2013-03-15 | 2014-09-18 | Diadexus, Inc. | Lipoprotein-associated phospholipase a2 antibody compositions and methods of use |
| SG10201912621TA (en) | 2013-03-15 | 2020-02-27 | Genentech Inc | Cell culture compositions with antioxidants and methods for polypeptide production |
| EP2968541A4 (en) | 2013-03-15 | 2017-02-08 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9447193B2 (en) | 2013-03-24 | 2016-09-20 | Development Center For Biotechnology | Methods for suppressing cancer by inhibition of TMCC3 |
| KR20230109779A (ko) | 2013-03-27 | 2023-07-20 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한섬유증 및 염증의 완화 및 반전 |
| JP6615745B2 (ja) | 2013-03-27 | 2019-12-04 | ジェネンテック， インコーポレイテッド | ベータ７インテグリンアンタゴニストによる胃腸炎症障害の治療を評価するためのバイオマーカーの使用 |
| WO2014165818A2 (en) | 2013-04-05 | 2014-10-09 | T Cell Therapeutics, Inc. | Compositions and methods for preventing and treating prostate cancer |
| US20160053023A1 (en) | 2013-04-09 | 2016-02-25 | Annexon, Inc. | Methods of treatment for neuromyelitis optica |
| US10544461B2 (en) | 2013-04-16 | 2020-01-28 | The Johns Hopkins University | Diagnostic and prognostic test for sturge-weber syndrome, klippel-trenaunay-weber syndrome, and port-wine stains (PWSS) |
| CA2910553A1 (en) | 2013-04-30 | 2014-11-06 | Universite De Montreal | Novel biomarkers for acute myeloid leukemia |
| US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| WO2014182972A2 (en) | 2013-05-10 | 2014-11-13 | The Regents Of The University Of California | Diagnostic and monitoring system for huntington's disease |
| UA119235C2 (uk) | 2013-05-20 | 2019-05-27 | Дженентек, Інк. | Антитіло анти-рецептор трансферину і способи його застосування |
| EP2999717B1 (en) | 2013-05-21 | 2018-08-08 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Treatment of mast cell related pathologies |
| WO2014186878A1 (en) | 2013-05-24 | 2014-11-27 | Cashman Neil R | Cell senescence markers as diagnostic and therapeutic targets |
| AR096601A1 (es) | 2013-06-21 | 2016-01-20 | Novartis Ag | Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso |
| WO2014210397A1 (en) | 2013-06-26 | 2014-12-31 | Academia Sinica | Rm2 antigens and use thereof |
| EP3013347B1 (en) | 2013-06-27 | 2019-12-11 | Academia Sinica | Glycan conjugates and use thereof |
| CA2916259C (en) | 2013-06-28 | 2024-02-20 | Amgen Inc. | Methods for treating homozygous familial hypercholesterolemia |
| US20160176943A1 (en) | 2013-07-05 | 2016-06-23 | Inserm (Insititut National De La Sante Et De La Recherche Medicale) | Novel alternative splice transcripts for mhc class i related chain alpha (mica) and uses thereof |
| EP4252769A3 (en) | 2013-07-09 | 2023-11-29 | Annexon, Inc. | Anti-complement factor c1q antibodies and uses thereof |
| WO2015006555A2 (en) | 2013-07-10 | 2015-01-15 | Sutro Biopharma, Inc. | Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
| PL3019516T3 (pl) | 2013-07-12 | 2019-04-30 | Hoffmann La Roche | Objaśnienie optymalizacji wprowadzania w chromatografii jonowymiennej |
| ES2819209T3 (es) | 2013-07-16 | 2021-04-15 | Hoffmann La Roche | Procedimientos de tratamiento del cáncer usando antagonistas de unión al eje de PD-1 e inhibidores de TIGIT |
| US20160168231A1 (en) | 2013-07-18 | 2016-06-16 | Fabrus, Inc. | Antibodies with ultralong complementarity determining regions |
| EP3022221B1 (en) | 2013-07-18 | 2021-09-15 | Taurus Biosciences, LLC | Humanized antibodies with ultralong complementarity determining regions |
| US10316083B2 (en) | 2013-07-19 | 2019-06-11 | Cedars-Sinai Medical Center | Signature of TL1A (TNFSF15) signaling pathway |
| WO2015015489A1 (en) | 2013-07-30 | 2015-02-05 | Biolinerx Ltd. | Antibody for treating diabetes and autoimmune diseases |
| SG11201600171SA (en) | 2013-08-02 | 2016-02-26 | Pfizer | Anti-cxcr4 antibodies and antibody-drug conjugates |
| CA2920666A1 (en) | 2013-08-12 | 2015-02-19 | Genentech, Inc. | Compositions and method for treating complement-associated conditions |
| CA2921398C (en) | 2013-08-14 | 2021-12-14 | The Governing Council Of The University Of Toronto | Antibodies for inhibiting frizzled receptors and pharmaceutical compositions containing antibodies for inhibiting frizzled receptors |
| JP2016528247A (ja) | 2013-08-14 | 2016-09-15 | ノバルティス アーゲー | 孤発性封入体筋炎を治療する方法 |
| WO2015031541A1 (en) | 2013-08-28 | 2015-03-05 | Stem Centrx, Inc. | Novel sez6 modulators and methods of use |
| ES2871418T3 (es) | 2013-08-28 | 2021-10-28 | Abbvie Stemcentrx Llc | Composiciones y métodos de conjugación de anticuerpos específicos de sitio |
| EA201690492A1 (ru) | 2013-08-29 | 2016-08-31 | Сити Оф Хоуп | Проникающие в клетку конъюгаты и способы их применения |
| US10456470B2 (en) | 2013-08-30 | 2019-10-29 | Genentech, Inc. | Diagnostic methods and compositions for treatment of glioblastoma |
| TW201605896A (zh) | 2013-08-30 | 2016-02-16 | 安美基股份有限公司 | Gitr抗原結合蛋白 |
| US10617755B2 (en) | 2013-08-30 | 2020-04-14 | Genentech, Inc. | Combination therapy for the treatment of glioblastoma |
| AU2014312086B2 (en) | 2013-08-30 | 2020-03-12 | Immunogen, Inc. | Antibodies and assays for detection of folate receptor 1 |
| WO2015033343A1 (en) | 2013-09-03 | 2015-03-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Compositions and methods for expressing recombinant polypeptides |
| CA2922832A1 (en) | 2013-09-05 | 2015-03-12 | Genentech, Inc. | Method for chromatography reuse |
| KR102298172B1 (ko) | 2013-09-06 | 2021-09-06 | 아카데미아 시니카 | 변화된 글리코실 그룹을 갖는 당지질을 사용한 인간 iNKT 세포 활성화 |
| CN111732652A (zh) | 2013-09-09 | 2020-10-02 | 卡尼姆盖德治疗学公司 | 免疫系统调节器 |
| JP6546178B2 (ja) | 2013-09-13 | 2019-07-17 | ジェネンテック， インコーポレイテッド | 細胞株中の宿主細胞タンパク質及び組換えポリペプチド産物を検出及び定量化するための組成物並びに方法 |
| KR102373930B1 (ko) | 2013-09-13 | 2022-03-11 | 제넨테크, 인크. | 정제된 재조합 폴리펩티드를 포함하는 방법 및 조성물 |
| WO2015037009A1 (en) | 2013-09-16 | 2015-03-19 | Plexicure Ltd. | Isolated proteins capable of binding plexin-a4 and methods of producing and using same |
| EP3047276B1 (en) | 2013-09-19 | 2023-06-14 | Dana-Farber Cancer Institute, Inc. | Methods of bh3 profiling |
| EP3049438B1 (en) | 2013-09-24 | 2018-07-25 | The Feinstein Institute for Medical Research | Peptides inhibiting cold-inducible rna binding protein activity |
| US9974788B2 (en) | 2013-09-26 | 2018-05-22 | Beth Israel Deaconess Medical Center, Inc. | Inhibition of SGK1 in the treatment of heart conditions |
| BR112016006397B1 (pt) | 2013-09-27 | 2024-01-16 | Genentech, Inc | Formulações de anticorpo de anti-pdl1, seu uso, artigo de fabricação e composição |
| WO2015048819A1 (en) | 2013-09-30 | 2015-04-02 | The Regents Of The University Of California | Anti-alphavbeta1 integrin compounds and methods |
| EP3051942B1 (en) | 2013-10-01 | 2020-09-02 | Kymab Limited | Animal models and therapeutic molecules |
| WO2015050959A1 (en) | 2013-10-01 | 2015-04-09 | Yale University | Anti-kit antibodies and methods of use thereof |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| SG10201907042PA (en) | 2013-10-08 | 2019-09-27 | Immunogen Inc | Anti-folr1 immunoconjugate dosing regimens |
| WO2015054427A1 (en) | 2013-10-10 | 2015-04-16 | Beth Israel Deaconess Medical Center, Inc. | Tm4sf1 binding proteins and methods of using same |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| ES2893861T3 (es) | 2013-10-24 | 2022-02-10 | Astrazeneca Ab | Formulaciones de anticuerpo estables, acuosas |
| WO2015069718A2 (en) | 2013-11-05 | 2015-05-14 | Bio-Rad Laboratories, Inc. | Pre-haptoglobin-2 monoclonal antibodies and uses thereof |
| AU2014346770B2 (en) | 2013-11-06 | 2020-05-21 | Janssen Biotech, Inc. | Anti-CCL17 antibodies |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| JP2016538286A (ja) | 2013-11-15 | 2016-12-08 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 膵臓癌を処置するための方法及び医薬組成物 |
| EP3763387B1 (en) | 2013-11-25 | 2024-03-27 | FameWave Ltd | Compositions comprising anti-ceacam1 and anti-pd antibodies for cancer therapy |
| TW201610168A (zh) | 2013-12-02 | 2016-03-16 | 安可美德藥物股份有限公司 | 與Ｗｎｔ途徑抑制劑有關之預測性生物標記之鑑別 |
| CA2932767A1 (en) | 2013-12-06 | 2015-06-11 | Dana-Farber Cancer Institute, Inc. | Therapeutic peptides |
| CN106030310B (zh) | 2013-12-13 | 2019-01-04 | 通用医疗公司 | 可溶性高分子量(hmw)tau种类及其应用 |
| BR112016013514B1 (pt) | 2013-12-13 | 2022-04-19 | Stora Enso Oyj (Fi) | Papelão de múltiplas camadas |
| US8980273B1 (en) | 2014-07-15 | 2015-03-17 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
| US9067998B1 (en) | 2014-07-15 | 2015-06-30 | Kymab Limited | Targeting PD-1 variants for treatment of cancer |
| US9017678B1 (en) | 2014-07-15 | 2015-04-28 | Kymab Limited | Method of treating rheumatoid arthritis using antibody to IL6R |
| US9034332B1 (en) | 2014-07-15 | 2015-05-19 | Kymab Limited | Precision medicine by targeting rare human PCSK9 variants for cholesterol treatment |
| EP3083692B1 (en) | 2013-12-17 | 2020-02-19 | F.Hoffmann-La Roche Ag | Methods of treating her2-positive cancers using pd-1 axis binding antagonists and anti-her2 antibodies |
| US8883157B1 (en) | 2013-12-17 | 2014-11-11 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
| US8986691B1 (en) | 2014-07-15 | 2015-03-24 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
| AU2014364606A1 (en) | 2013-12-17 | 2016-07-07 | Genentech, Inc. | Combination therapy comprising OX40 binding agonists and PD-1 axis binding antagonists |
| US8986694B1 (en) | 2014-07-15 | 2015-03-24 | Kymab Limited | Targeting human nav1.7 variants for treatment of pain |
| US9045545B1 (en) | 2014-07-15 | 2015-06-02 | Kymab Limited | Precision medicine by targeting PD-L1 variants for treatment of cancer |
| US9045548B1 (en) | 2014-07-15 | 2015-06-02 | Kymab Limited | Precision Medicine by targeting rare human PCSK9 variants for cholesterol treatment |
| US8992927B1 (en) | 2014-07-15 | 2015-03-31 | Kymab Limited | Targeting human NAV1.7 variants for treatment of pain |
| US8945560B1 (en) | 2014-07-15 | 2015-02-03 | Kymab Limited | Method of treating rheumatoid arthritis using antibody to IL6R |
| US9023359B1 (en) | 2014-07-15 | 2015-05-05 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
| CA2933881A1 (en) | 2013-12-17 | 2015-06-25 | Genentech, Inc. | Methods of treating cancer using pd-1 axis binding antagonists and an anti-cd20 antibody |
| US9914769B2 (en) | 2014-07-15 | 2018-03-13 | Kymab Limited | Precision medicine for cholesterol treatment |
| US9051378B1 (en) | 2014-07-15 | 2015-06-09 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
| KR102597804B1 (ko) | 2013-12-20 | 2023-11-07 | 제넨테크, 인크. | 이중 특이적 항체 |
| ES2920677T3 (es) | 2013-12-24 | 2022-08-08 | Janssen Pharmaceutica Nv | Anticuerpos y fragmentos anti-VISTA |
| US11014987B2 (en) | 2013-12-24 | 2021-05-25 | Janssen Pharmaceutics Nv | Anti-vista antibodies and fragments, uses thereof, and methods of identifying same |
| EP4101461A1 (en) | 2014-01-09 | 2022-12-14 | Hadasit Medical Research Services and Development Ltd. | Improved cell compositions and methods for cancer therapy |
| JP7037884B2 (ja) | 2014-01-13 | 2022-03-17 | ベイラー リサーチ インスティテュート | Ｈｐｖ及びｈｐｖ関連疾患に対する新規のワクチン |
| US10266586B2 (en) | 2014-01-14 | 2019-04-23 | The Medical College Of Wisconsin, Inc. | Targeting CLPTM1L for treatment and prevention of cancer |
| US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| CA2937123A1 (en) | 2014-01-16 | 2015-07-23 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| WO2016114819A1 (en) | 2015-01-16 | 2016-07-21 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| SG11201606018UA (en) | 2014-01-24 | 2016-08-30 | Ngm Biopharmaceuticals Inc | Binding proteins and methods of use thereof |
| WO2015116902A1 (en) | 2014-01-31 | 2015-08-06 | Genentech, Inc. | G-protein coupled receptors in hedgehog signaling |
| US20170042893A1 (en) | 2014-02-03 | 2017-02-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Use of casein kinase i inhibitors for depleting stem cells |
| CA2937539A1 (en) | 2014-02-04 | 2015-08-13 | Genentech, Inc. | Mutant smoothened and methods of using the same |
| WO2015118537A2 (en) | 2014-02-05 | 2015-08-13 | Yeda Research And Development Co. Ltd. | Micro-rnas and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions |
| ES2696348T3 (es) | 2014-02-06 | 2019-01-15 | Yeda Res & Dev | Anticuerpos anti CD84, composiciones que comprenden los mismos y usos de los mismos |
| JP2017506640A (ja) | 2014-02-14 | 2017-03-09 | セントローズ， エルエルシー | 細胞外標的化薬物共役体 |
| WO2015124588A1 (en) | 2014-02-18 | 2015-08-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of diseases mediated by the nrp-1/obr complex signaling pathway |
| WO2015124570A1 (en) | 2014-02-18 | 2015-08-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the treatment of influenza a virus infection |
| US10308721B2 (en) | 2014-02-21 | 2019-06-04 | Abbvie Stemcentrx Llc | Anti-DLL3 antibodies and drug conjugates for use in melanoma |
| SG11201606546VA (en) | 2014-02-27 | 2016-09-29 | Gilead Sciences Inc | Antibodies to matrix metalloproteinase 9 and methods of use thereof |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| CN106456728A (zh) | 2014-03-14 | 2017-02-22 | 达纳－法伯癌症研究所公司 | 恢复对抗癌症的nkg2d通路功能的疫苗组合物和方法 |
| US20170174751A1 (en) | 2014-03-19 | 2017-06-22 | Dana-Farber Cancer Institute, Inc. | Immunogenetic restriction on elicitation of antibodies |
| US10556945B2 (en) | 2014-03-21 | 2020-02-11 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| WO2015140351A1 (en) | 2014-03-21 | 2015-09-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for enhancing myelination |
| CN106164092A (zh) | 2014-03-21 | 2016-11-23 | 瑞泽恩制药公司 | 表现不同结合特征的vl抗原结合蛋白 |
| EP3895528A1 (en) | 2014-03-21 | 2021-10-20 | Regeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
| KR20220130822A (ko) | 2014-03-21 | 2022-09-27 | 테바 파마슈티컬스 인터내셔널 게엠베하 | 칼시토닌 유전자-관련 펩티드에 대한 길항제 항체 및 그의 사용 방법 |
| AU2015236008B2 (en) | 2014-03-25 | 2018-12-20 | Genentech, Inc. | Methods of preparing a poloxamer for use in cell culture medium |
| WO2015145449A2 (en) | 2014-03-27 | 2015-10-01 | Yeda Research And Development Co. Ltd. | T-cell receptor cdr3 peptides and antibodies |
| CN106415244B (zh) | 2014-03-27 | 2020-04-24 | 中央研究院 | 反应性标记化合物及其用途 |
| AU2015235986B2 (en) | 2014-03-27 | 2020-12-03 | Genentech, Inc. | Methods for diagnosing and treating inflammatory bowel disease |
| RU2016142476A (ru) | 2014-03-31 | 2018-05-07 | Дженентек, Инк. | Комбинированная терапия, включающая антиангиогенезные агенты и агонисты, связывающие ох40 |
| MX2016012873A (es) | 2014-04-04 | 2017-03-07 | Bionomics Inc | Anticuerpos humanizados que se unen al receptor 5 acoplado a proteina g que contiene repeticion rica en leucina (lgr5). |
| US10022443B2 (en) | 2014-04-08 | 2018-07-17 | Boston Pharmaceuticals Inc. | Antibodies specific for IL-21 and uses thereof |
| TW201622746A (zh) | 2014-04-24 | 2016-07-01 | 諾華公司 | 改善或加速髖部骨折術後身體復原之方法 |
| EP3134111B1 (en) | 2014-04-25 | 2022-06-08 | Dana-Farber Cancer Institute, Inc. | Middle east respiratory syndrome coronavirus neutralizing antibodies and methods of use thereof |
| AP2016009504A0 (en) | 2014-04-27 | 2016-10-31 | Ccam Biotherapeutics Ltd | Humanized antibodies against ceacam1 |
| US11427647B2 (en) | 2014-04-27 | 2022-08-30 | Famewave Ltd. | Polynucleotides encoding humanized antibodies against CEACAM1 |
| US9753036B2 (en) | 2014-04-29 | 2017-09-05 | Edp Biotech Corporation | Methods and compositions for screening and detecting biomarkers |
| DK3137114T3 (da) | 2014-04-30 | 2021-01-25 | Pfizer | Anti-PTK7-antistof-lægemiddelkonjugater |
| EP3888690A3 (en) | 2014-05-16 | 2021-10-20 | MedImmune, LLC | Molecules with altered neonate fc receptor binding having enhanced therapeutic and diagnostic properties |
| EP3467501B1 (en) | 2014-05-16 | 2020-11-04 | Amgen Inc. | Assay for detecting th1 and th2 cell populations |
| EP3145953A1 (en) | 2014-05-21 | 2017-03-29 | Dana-Farber Cancer Institute, Inc. | Methods for treating cancer with anti bip or anti mica antibodies |
| US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| KR20220151036A (ko) | 2014-05-27 | 2022-11-11 | 아카데미아 시니카 | 항-ｃｄ20 글리코항체 및 이의 용도 |
| EP3149045B1 (en) | 2014-05-27 | 2023-01-18 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| WO2015184002A1 (en) | 2014-05-27 | 2015-12-03 | Academia Sinica | Anti-her2 glycoantibodies and uses thereof |
| WO2015184001A1 (en) | 2014-05-28 | 2015-12-03 | Academia Sinica | Anti-tnf-alpha glycoantibodies and uses thereof |
| GB201409558D0 (en) | 2014-05-29 | 2014-07-16 | Ucb Biopharma Sprl | Method |
| KR102366644B1 (ko) | 2014-05-30 | 2022-02-22 | 상하이 헨리우스 바이오테크, 인크. | 항-표피 성장 인자 수용체 (egfr) 항체 |
| MX2016015893A (es) | 2014-06-02 | 2017-03-20 | Lab Francais Du Fractionnement | Produccion de fragmentos de fragmento cristalizable (fc). |
| WO2015186129A1 (en) | 2014-06-02 | 2015-12-10 | Technion Research & Development Foundation Limited. | Compositions and methods of selectively inhibiting irp1 and treating inflammation |
| EP3610924B1 (en) | 2014-06-06 | 2021-11-03 | Bristol-Myers Squibb Company | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof |
| BR112016028750A2 (pt) | 2014-06-11 | 2017-11-14 | Gilead Sciences Inc | ?métodos para tratar, prevenir, ou melhorar pelo menos um sintoma associado e para diagnosticar e monitorar insuficiência cardíaca ou fibrilação atrial, inibidor da lisil oxidase ativa ou proteína lisil tipo oxidase, e, composição? |
| MX2016016310A (es) | 2014-06-11 | 2017-10-20 | A Green Kathy | Uso de agonistas y antagonistas vista para suprimir o aumentar la inmunidad humoral. |
| WO2015195835A2 (en) | 2014-06-17 | 2015-12-23 | The Regents Of The University Of California | Improved alpha-v beta-8 antibodies |
| TWI695011B (zh) | 2014-06-18 | 2020-06-01 | 美商梅爾莎納醫療公司 | 抗ｈｅｒ２表位之單株抗體及其使用之方法 |
| CA2952876A1 (en) | 2014-06-20 | 2015-12-23 | Bioalliance C.V. | Anti-folate receptor alpha (fra) antibody-drug conjugates and methods of using thereof |
| BR112016029460A2 (pt) | 2014-06-23 | 2017-10-24 | Five Prime Therapeutics Inc | métodos para tratar artrite reumatoide |
| US20170183376A1 (en) | 2014-06-24 | 2017-06-29 | Insight Biopharmaceuticals Ltd. | Methods of purifying antibodies |
| WO2015198243A2 (en) | 2014-06-25 | 2015-12-30 | Novartis Ag | Compositions and methods for long acting proteins |
| EP3161001A2 (en) | 2014-06-25 | 2017-05-03 | Novartis AG | Antibodies specific for il-17a fused to hyaluronan binding peptide tags |
| US20170327553A1 (en) | 2014-06-25 | 2017-11-16 | Novartis Ag | Compositions and methods for long acting proteins |
| GB201411320D0 (en) | 2014-06-25 | 2014-08-06 | Ucb Biopharma Sprl | Antibody construct |
| WO2016004383A1 (en) | 2014-07-03 | 2016-01-07 | City Of Hope | Tumor-selective ctla-4 antagonists |
| EP3167395B1 (en) | 2014-07-07 | 2020-09-02 | Yeda Research and Development Co., Ltd. | Method of computational protein design |
| EP3166688A4 (en) | 2014-07-08 | 2017-12-20 | New York University | Tau imaging ligands and their uses in the diagnosis and treatment of tauopathy |
| CA2953154C (en) | 2014-07-09 | 2023-03-14 | Genentech, Inc. | Ph adjustment to improve thaw recovery of cell banks |
| PT3169706T (pt) | 2014-07-11 | 2020-03-13 | Genmab As | Anticorpos que se ligam a axl |
| JP2017523776A (ja) | 2014-07-14 | 2017-08-24 | ジェネンテック， インコーポレイテッド | 膠芽腫の診断方法及びその治療用組成物 |
| BR112017000672A2 (pt) | 2014-07-15 | 2017-11-14 | Genentech Inc | composições para tratamento de câncer utilizando antagonistas de ligação de eixo pd-1 e inibidores de mek |
| US9150660B1 (en) | 2014-07-15 | 2015-10-06 | Kymab Limited | Precision Medicine by targeting human NAV1.8 variants for treatment of pain |
| US9139648B1 (en) | 2014-07-15 | 2015-09-22 | Kymab Limited | Precision medicine by targeting human NAV1.9 variants for treatment of pain |
| JP6671363B2 (ja) | 2014-07-15 | 2020-03-25 | イッサム リサーチ ディヴェロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミティッド | Ｃｄ４４の単離されたポリペプチドおよびその使用 |
| GB201412659D0 (en) | 2014-07-16 | 2014-08-27 | Ucb Biopharma Sprl | Molecules |
| GB201412658D0 (en) | 2014-07-16 | 2014-08-27 | Ucb Biopharma Sprl | Molecules |
| ES2753551T3 (es) | 2014-07-22 | 2020-04-13 | Sutro Biopharma Inc | Anticuerpos anti-cd74, composiciones que comprenden anticuerpos anti-CD74 y procedimientos de uso de los anticuerpos anti-CD74 |
| MX2017001403A (es) | 2014-07-31 | 2017-07-07 | Amgen Res (Munich) Gmbh | Constructo de anticuerpo de cadena individual biespecifico con distribucion mejorada de tejido. |
| CA2956471A1 (en) | 2014-07-31 | 2016-02-04 | Amgen Research (Munich) Gmbh | Optimized cross-species specific bispecific single chain antibody constructs |
| AR101669A1 (es) | 2014-07-31 | 2017-01-04 | Amgen Res (Munich) Gmbh | Constructos de anticuerpos para cdh19 y cd3 |
| US20170226209A1 (en) | 2014-08-01 | 2017-08-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | An anti-cd45rc antibody for use as drug |
| KR20220165831A (ko) | 2014-08-04 | 2022-12-15 | 온코세라피 사이언스 가부시키가이샤 | Urlc10-유래 펩티드 및 이를 포함하는 백신 |
| KR20170040315A (ko) | 2014-08-04 | 2017-04-12 | 온코세라피 사이언스 가부시키가이샤 | Cdca1-유래 펩티드 및 이를 포함하는 백신 |
| CN111925414A (zh) | 2014-08-04 | 2020-11-13 | 肿瘤疗法科学股份有限公司 | Koc1衍生的肽和包含它们的疫苗 |
| US9982052B2 (en) | 2014-08-05 | 2018-05-29 | MabQuest, SA | Immunological reagents |
| SG11201700672YA (en) | 2014-08-05 | 2017-02-27 | MabQuest SA | Immunological reagents binding to pd-1 |
| WO2016020799A1 (en) | 2014-08-06 | 2016-02-11 | Rinat Neuroscience Corp. | Methods for reducing ldl-cholesterol |
| US20170224816A1 (en) | 2014-08-06 | 2017-08-10 | Rinat Neuroscience Corp. | Methods for reducing ldl-cholesterol |
| ES2906216T3 (es) | 2014-08-07 | 2022-04-13 | Novartis Ag | Anticuerpos de 4 similar a la angiopoyetina y métodos de uso |
| US9988443B2 (en) | 2014-08-07 | 2018-06-05 | Novartis Ag | Angiopoetin-like 4 (ANGPTL4) antibodies and methods of use |
| SG11201700901SA (en) | 2014-08-08 | 2017-03-30 | Alector Llc | Anti-trem2 antibodies and methods of use thereof |
| HRP20220738T1 (hr) | 2014-08-11 | 2022-08-19 | Acerta Pharma B.V. | Terapijske kombinacije inhibitora btk, inhibitora pd-1 i/ili inhibitora pd-l1 |
| WO2016026978A1 (en) | 2014-08-22 | 2016-02-25 | Universite Nice Sophia Antipolis | Methods and pharmaceutical compositions for treating drug addiction |
| FR3025515B1 (fr) | 2014-09-05 | 2016-09-09 | Lab Francais Du Fractionnement | Procede de purification d'un anticorps monoclonal |
| US10526416B2 (en) | 2014-09-08 | 2020-01-07 | Yeda Research And Development Co. Ltd. | Anti-HER3 antibodies and uses of same |
| EP3191523B1 (en) | 2014-09-08 | 2019-08-07 | Yeda Research and Development Co., Ltd. | Compositions and methods for treating cancer resistant to a tyrosine kinase inhibitor (tki) |
| JP6899321B2 (ja) | 2014-09-08 | 2021-07-07 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | 糖脂質を使用するヒトｉＮＫＴ細胞活性化 |
| WO2016040767A2 (en) | 2014-09-12 | 2016-03-17 | Amgen Inc. | Chrdl-1 epitopes and antibodies |
| IL234638A0 (en) | 2014-09-14 | 2014-12-02 | Yeda Res & Dev | NMDA receptor antagonists for the treatment of Gaucher disease |
| BR112017004393A2 (pt) | 2014-09-15 | 2018-02-27 | Genentech Inc | formulações de anticorpo |
| MX2017003247A (es) | 2014-09-15 | 2017-11-30 | Amgen Inc | Proteina de union a antigenos, bi-especificos del receptor anti-cgrp/receptor pac1 y usos de las mismas. |
| WO2016043577A1 (en) | 2014-09-16 | 2016-03-24 | Academisch Medisch Centrum | Ig-like molecules binding to bmp4 |
| US10222386B2 (en) | 2014-09-19 | 2019-03-05 | The Johns Hopkins University | Biomarkers of congnitive dysfunction |
| US10080790B2 (en) | 2014-09-19 | 2018-09-25 | The Regents Of The University Of Michigan | Staphylococcus aureus materials and methods |
| US10472424B2 (en) | 2014-09-23 | 2019-11-12 | Pfizer Inc. | Treatment with anti-PCSK9 antibodies |
| US10365280B2 (en) | 2014-10-02 | 2019-07-30 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating malignancies |
| RU2017115315A (ru) | 2014-10-03 | 2018-11-08 | Дана-Фарбер Кэнсер Инститьют, Инк. | Антитела к рецептору глюкокортикоид-индуцированного фактора некроза опухоли (gitr) и способы их применения |
| AU2015327819B2 (en) | 2014-10-03 | 2021-07-01 | Massachusetts Institute Of Technology | Antibodies that bind ebola glycoprotein and uses thereof |
| EP3699196A1 (en) | 2014-10-06 | 2020-08-26 | Dana Farber Cancer Institute, Inc. | Humanized cc chemokine receptor 4 (ccr4) antibodies and methods of use thereof |
| US9921230B2 (en) | 2014-10-08 | 2018-03-20 | Rhode Island Hospital | Methods for diagnosis and treatment of concussion or brain injury |
| CA2964313C (en) | 2014-10-15 | 2023-03-14 | Amgen Inc. | Promoter and regulatory elements for improved expression of heterologous genes in host cells |
| WO2016059220A1 (en) | 2014-10-16 | 2016-04-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Tcr-activating agents for use in the treatment of t-all |
| US9585934B2 (en) | 2014-10-22 | 2017-03-07 | Extend Biosciences, Inc. | Therapeutic vitamin D conjugates |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| BR112017008914A2 (pt) | 2014-10-29 | 2018-01-16 | Five Prime Therapeutics, Inc. | método para tratar câncer, composição e uso da composição |
| CA2966042A1 (en) | 2014-10-31 | 2016-05-06 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
| JP6672293B2 (ja) | 2014-10-31 | 2020-03-25 | メディミューン，エルエルシー | 改善された製造方法 |
| US10738078B2 (en) | 2014-11-03 | 2020-08-11 | Bristol-Myers Squibb Company | Use of caprylic acid precipitation for protein purification |
| US10302644B2 (en) | 2014-11-04 | 2019-05-28 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating multiple myeloma |
| KR102544705B1 (ko) | 2014-11-05 | 2023-06-15 | 제넨테크, 인크. | 박테리아 내 2쇄 단백질을 생산하는 방법 |
| SG11201703667SA (en) | 2014-11-05 | 2017-06-29 | Annexon Inc | Humanized anti-complement factor c1q antibodies and uses thereof |
| WO2016073791A1 (en) | 2014-11-05 | 2016-05-12 | Genentech, Inc. | Methods of producing two chain proteins in bacteria |
| RU2017119428A (ru) | 2014-11-06 | 2018-12-06 | Дженентек, Инк. | Комбинированная терапия, включающая применение агонистов, связывающихся с ох40, и ингибиторов tigit |
| WO2016073157A1 (en) | 2014-11-06 | 2016-05-12 | Genentech, Inc. | Anti-ang2 antibodies and methods of use thereof |
| WO2016073894A1 (en) | 2014-11-07 | 2016-05-12 | Eleven Biotherapeutics, Inc. | Therapeutic agents with increased ocular retention |
| CN107249631B (zh) | 2014-11-07 | 2021-11-23 | 十一生物治疗股份有限公司 | 改进的il-6抗体 |
| ES2877080T3 (es) | 2014-11-10 | 2021-11-16 | Medimmune Ltd | Moléculas de unión específicas para cd73 y usos de las mismas |
| GB2538120A (en) | 2014-11-11 | 2016-11-09 | Medimmune Ltd | Therapeutic combinations comprising anti-CD73 antibodies and uses thereof |
| EP3221360A1 (en) | 2014-11-17 | 2017-09-27 | F. Hoffmann-La Roche AG | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
| WO2016079736A2 (en) | 2014-11-17 | 2016-05-26 | Yeda Research And Development Co. Ltd. | Methods of treating diseases related to mitochondrial function |
| WO2016081640A1 (en) | 2014-11-19 | 2016-05-26 | Genentech, Inc. | Anti-transferrin receptor / anti-bace1 multispecific antibodies and methods of use |
| EP3221362B1 (en) | 2014-11-19 | 2019-07-24 | F.Hoffmann-La Roche Ag | Anti-transferrin receptor antibodies and methods of use |
| US10517898B2 (en) | 2014-11-20 | 2019-12-31 | The Regents Of The University Of California | Compositions and methods related to hematologic recovery |
| EA035766B1 (ru) | 2014-11-21 | 2020-08-07 | Бристол-Майерс Сквибб Компани | Антитело к cd73 и его применения |
| EP3224276B1 (en) | 2014-11-25 | 2020-06-17 | Technion Research & Development Foundation Limited | Novel epitope as a target for therapy of inflammatory autoimmune diseases and graft rejection |
| WO2016087514A1 (en) | 2014-12-02 | 2016-06-09 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | Anti-mutant calreticulin antibodies and their use in the diagnosis and therapy of myeloid malignancies |
| US20170319661A1 (en) | 2014-12-03 | 2017-11-09 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and Pharmaceutical Compositions Using Orexins (OXA, OXB) for the Treatment of Prostate Cancers |
| JP2017537929A (ja) | 2014-12-05 | 2017-12-21 | ジェネンテック， インコーポレイテッド | Ｐｄ−１軸アンタゴニスト及びｈｐｋ１アンタゴニストを用いたがん治療のための方法及び組成物 |
| WO2016090347A1 (en) | 2014-12-05 | 2016-06-09 | Immunext, Inc. | Identification of vsig8 as the putative vista receptor and its use thereof to produce vista/vsig8 modulators |
| JP2018502840A (ja) | 2014-12-10 | 2018-02-01 | ジェネンテック， インコーポレイテッド | 血液脳関門受容体抗体及び使用方法 |
| AU2015365583B2 (en) | 2014-12-19 | 2021-10-28 | Regenesance B.V. | Antibodies that bind human C6 and uses thereof |
| UY36449A (es) | 2014-12-19 | 2016-07-29 | Novartis Ag | Composiciones y métodos para anticuerpos dirigidos a bmp6 |
| ES2843586T3 (es) | 2014-12-22 | 2021-07-19 | Five Prime Therapeutics Inc | Anticuerpos dirigidos contra CSF1R para tratar la SVNP |
| CA2971732A1 (en) | 2014-12-23 | 2016-06-30 | Bristol-Myers Squibb Company | Antibodies to tigit |
| EP3244907B1 (en) | 2015-01-13 | 2020-02-19 | City of Hope | Ctla4-binding protein peptide-linker masks |
| AR103428A1 (es) | 2015-01-16 | 2017-05-10 | Hope City | Anticuerpos de penetración celular |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| CA2972072A1 (en) | 2015-01-24 | 2016-07-28 | Academia Sinica | Novel glycan conjugates and methods of use thereof |
| CA2972731A1 (en) | 2015-01-24 | 2016-07-28 | Chi-Huey Wong | Cancer markers and methods of use thereof |
| CN107407677B (zh) | 2015-01-28 | 2020-07-17 | 豪夫迈·罗氏有限公司 | 多发性硬化的基因表达标志和治疗 |
| JP6942633B2 (ja) | 2015-01-30 | 2021-09-29 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | 抗体の増強された有効性のための普遍的グリコフォームに関する組成物および方法 |
| CN105985435B (zh) * | 2015-01-30 | 2019-10-15 | 嘉和生物药业有限公司 | 全人源her2抗体的突变抗体及其编码基因和应用 |
| JP2018512597A (ja) | 2015-02-04 | 2018-05-17 | ジェネンテック， インコーポレイテッド | 突然変異体スムースンド及びその使用方法 |
| WO2016128912A1 (en) | 2015-02-12 | 2016-08-18 | Acerta Pharma B.V. | Therapeutic combinations of a btk inhibitor, a pi3k inhibitor, a jak-2 inhibitor, a pd-1 inhibitor, and/or a pd-l1 inhibitor |
| WO2016128523A1 (en) | 2015-02-12 | 2016-08-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the responsiveness of a patient affected with malignant hematological disease to chemotherapy treatment and methods of treatment of such disease |
| US11497767B2 (en) | 2015-02-18 | 2022-11-15 | Enlivex Therapeutics R&D Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11318163B2 (en) | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11304976B2 (en) | 2015-02-18 | 2022-04-19 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| CA2972099A1 (en) | 2015-02-26 | 2016-09-01 | Genentech, Inc. | Integrin beta7 antagonists and methods of treating crohn's disease |
| CA2977607A1 (en) | 2015-02-26 | 2016-09-01 | Jacob Schneiderman | Methods and compositions relating to leptin antagonists |
| IL278423B2 (en) | 2015-02-26 | 2024-04-01 | Merck Patent Gmbh | Fidi-1 / Fidi-AL1 inhibitors for cancer treatment |
| US10711067B2 (en) | 2015-03-03 | 2020-07-14 | Xoma (Us) Llc | Treatment of post-prandial hyperinsulinemia and hypoglycemia after bariatric surgery |
| AU2016229309B2 (en) | 2015-03-06 | 2021-12-02 | Canimguide Therapeutics Ab | Immune system modulators and compositions |
| WO2016145258A1 (en) | 2015-03-10 | 2016-09-15 | The Regents Of The University Of California | Anti-alphavbeta1 integrin inhibitors and methods of use |
| EP3067062A1 (en) | 2015-03-13 | 2016-09-14 | Ipsen Pharma S.A.S. | Combination of tasquinimod or a pharmaceutically acceptable salt thereof and a pd1 and/or pdl1 inhibitor, for use as a medicament |
| BR112017018365A2 (pt) | 2015-03-13 | 2018-04-10 | Bristol-Myers Squibb Company | uso de lavagens alcalinas durante cromatografia para remoção de impurezas |
| CN107438622A (zh) | 2015-03-19 | 2017-12-05 | 瑞泽恩制药公司 | 选择结合抗原的轻链可变区的非人动物 |
| IL237852A0 (en) | 2015-03-19 | 2016-03-24 | Yeda Res & Dev | Antibodies against amphigoline, medical preparations containing them and their use |
| US20180105554A1 (en) | 2015-03-20 | 2018-04-19 | Bristol-Myers Squibb Company | Use of dextran sulfate to enhance protein a affinity chromatography |
| WO2016153983A1 (en) | 2015-03-20 | 2016-09-29 | Bristol-Myers Squibb Company | Use of dextran for protein purification |
| EP3273981B1 (en) | 2015-03-24 | 2020-04-29 | INSERM - Institut National de la Santé et de la Recherche Médicale | Method and pharmaceutical composition for use in the treatment of diabetes |
| EP3273971A4 (en) | 2015-03-27 | 2018-12-05 | Yeda Research and Development Co. Ltd. | Methods of treating motor neuron diseases |
| CA2981504C (en) | 2015-03-30 | 2023-10-24 | City Of Hope | Mechanically interlocking complexes |
| FR3034420A1 (fr) | 2015-03-31 | 2016-10-07 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-cd303 |
| US20180208658A1 (en) | 2015-04-03 | 2018-07-26 | Eureka Therapeutics, Inc. | Constructs targeting afp peptide/mhc complexes and uses thereof |
| EP3770171A1 (en) | 2015-04-03 | 2021-01-27 | XOMA Technology Ltd. | Treatment of cancer using inhibitors of tgf-beta and pd-1 |
| EP3280720A4 (en) | 2015-04-06 | 2018-12-05 | President and Fellows of Harvard College | Compositions and methods for non-myeloablative conditioning |
| AU2016245434B2 (en) | 2015-04-07 | 2020-10-29 | Ela Pharma Ltd | Compositions for treating and/or preventing cell or tissue necrosis specifically targeting Cathepsin C and/or CELA1 and/or CELA3A and/or structurally related enzymes thereto |
| WO2016164608A1 (en) | 2015-04-07 | 2016-10-13 | Alector Llc | Methods of screening for sortilin binding antagonists |
| CA2981851A1 (en) | 2015-04-07 | 2016-10-13 | Alector Llc | Anti-sortilin antibodies and methods of use thereof |
| JP6960856B2 (ja) | 2015-04-08 | 2021-11-05 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | ヒト化インフルエンザモノクローナル抗体およびその使用方法 |
| CA2925329C (en) | 2015-04-13 | 2024-01-02 | Pfizer Inc. | Anti-bcma antibodies, anti-cd3 antibodies and bi-specific antibodies binding to bcma and cd3 |
| US10851176B2 (en) | 2015-04-13 | 2020-12-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods of administering neutralizing anti-protease nexin-1 antibodies to treat hemophilia A |
| EP3757128A1 (en) | 2015-04-13 | 2020-12-30 | Pfizer Inc | Chimeric antigen receptors targeting b-cell maturation antigen |
| LT3283527T (lt) | 2015-04-13 | 2021-03-25 | Five Prime Therapeutics, Inc. | Kompleksinė terapija vėžio gydymui |
| TWI772258B (zh) | 2015-04-17 | 2022-08-01 | 德商安美基研究（慕尼黑）公司 | Ｃｄｈ３與ｃｄ３之雙特異性抗體構築體 |
| CA2982928A1 (en) | 2015-04-20 | 2016-10-27 | Tolero Pharmaceuticals, Inc. | Predicting response to alvocidib by mitochondrial profiling |
| GB201506870D0 (en) | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method |
| GB201506869D0 (en) | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method |
| EP3286221A1 (en) | 2015-04-22 | 2018-02-28 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical compositions for the treatment of th17 mediated diseases |
| JOP20200116A1 (ar) | 2015-04-24 | 2017-06-16 | Amgen Inc | طرق لعلاج أو الوقاية من الصداع النصفي |
| AU2016253957C1 (en) | 2015-04-27 | 2021-04-01 | Dana-Farber Cancer Institute, Inc. | High throughput BH3 profiling: a rapid and scalable technology to BH3 profile on low numbers of cells |
| EP3288977B1 (en) | 2015-05-01 | 2021-11-17 | Dana-Farber Cancer Institute, Inc. | Methods of mediating cytokine expression with anti ccr4 antibodies |
| EP3291839A1 (en) | 2015-05-05 | 2018-03-14 | The University of Louisville Research Foundation, Inc. | Anti-nucleolin agent-conjugated nanoparticles as radio-sensitizers and mri and/or x-ray contrast agents |
| EP3294771A1 (en) | 2015-05-11 | 2018-03-21 | H. Hoffnabb-La Roche Ag | Compositions and methods of treating lupus nephritis |
| US20180161300A1 (en) | 2015-05-11 | 2018-06-14 | Yeda Research And Development Co., Ltd. | Citrin inhibitors for the treatment of cancer |
| SI3294770T1 (sl) | 2015-05-12 | 2021-01-29 | F. Hoffmann-La Roche Ag | Terapevtski in diagnostični postopki za raka |
| WO2016187158A1 (en) | 2015-05-15 | 2016-11-24 | City Of Hope | Chimeric antigen receptor compositions |
| BR112017024933A8 (pt) | 2015-05-18 | 2022-10-18 | Tolero Pharmaceuticals Inc | Alvocidib produce com a bioavailabilidade aumentada |
| WO2016185457A1 (en) | 2015-05-19 | 2016-11-24 | Yeda Research And Development Co. Ltd. | Methods of promoting lymphangiogenesis |
| US10849985B2 (en) | 2015-05-20 | 2020-12-01 | Yeda Research And Development Co. Ltd. | Method of targeting senescent cells |
| EP3297674B1 (en) | 2015-05-22 | 2023-01-04 | Translational Drug Development Llc | Benzamide and active compound compositions and methods of use |
| SG10201911335TA (en) | 2015-05-28 | 2020-01-30 | Genentech Inc | Cell-based assay for detecting anti-cd3 homodimers |
| HRP20230060T1 (hr) | 2015-05-29 | 2023-03-17 | Bristol-Myers Squibb Company | Antitijela protiv ox40 i njihova primjena |
| JP6884111B2 (ja) | 2015-05-29 | 2021-06-09 | ジェネンテック， インコーポレイテッド | 癌におけるｐｄ−ｌ１プロモーターのメチル化 |
| MX2017014736A (es) | 2015-05-29 | 2018-03-23 | Genentech Inc | Metodos terapeuticos y diagnosticos para cancer. |
| AU2016269839B2 (en) | 2015-06-03 | 2021-07-08 | The University Of Queensland | Mobilizing agents and uses therefor |
| MX2017015690A (es) | 2015-06-05 | 2018-07-06 | Novartis Ag | Anticuerpos dirigidos a la proteina morfogenetica osea 9 (bmp9) y metodos a partir de estos. |
| NL2014935B1 (en) | 2015-06-08 | 2017-02-03 | Applied Immune Tech Ltd | T cell receptor like antibodies having fine specificity. |
| EP3307779A2 (en) | 2015-06-12 | 2018-04-18 | Alector LLC | Anti-cd33 antibodies and methods of use thereof |
| CN107922480B (zh) | 2015-06-12 | 2022-09-23 | 艾利妥 | 抗cd33抗体及其使用方法 |
| WO2016205277A1 (en) | 2015-06-16 | 2016-12-22 | Merck Patent Gmbh | Pd-l1 antagonist combination treatments |
| KR20180018538A (ko) | 2015-06-17 | 2018-02-21 | 제넨테크, 인크. | Pd-1 축 결합 길항제 및 탁산을 사용하여 국소적 진행성 또는 전이성 유방암을 치료하는 방법 |
| GB201510758D0 (en) | 2015-06-18 | 2015-08-05 | Ucb Biopharma Sprl | Novel TNFa structure for use in therapy |
| DK3313882T3 (da) | 2015-06-24 | 2020-05-11 | Janssen Pharmaceutica Nv | Anti-VISTA antistoffer og fragmenter |
| CN107922500A (zh) | 2015-06-29 | 2018-04-17 | 洛克菲勒大学 | 具有增强的激动剂活性的抗cd40抗体 |
| RU2739612C2 (ru) | 2015-06-29 | 2020-12-28 | Иммуноджен, Инк. | Анти-cd123 антитела и их конъюгаты и производные |
| BR112017027736A2 (pt) | 2015-06-29 | 2018-10-09 | Genentech Inc | anticorpo anti-cd20 tipo ii para uso no transplante de órgãos |
| CA2991805A1 (en) | 2015-07-10 | 2017-01-19 | Genmab A/S | Axl-specific antibody-drug conjugates for cancer treatment |
| JO3711B1 (ar) | 2015-07-13 | 2021-01-31 | H Lundbeck As | أجسام مضادة محددة لبروتين تاو وطرق استعمالها |
| GB201512215D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
| GB201512203D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
| GB201601075D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies molecules |
| GB201601077D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibody molecule |
| MX2017016844A (es) | 2015-07-16 | 2018-08-15 | Biokine Therapeutics Ltd | Composiciones y procedimientos para tratar cancer. |
| GB201601073D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies |
| WO2017015334A1 (en) | 2015-07-21 | 2017-01-26 | Saint Louis University | Compositions and methods for diagnosing and treating endometriosis-related infertility |
| TWI793062B (zh) | 2015-07-31 | 2023-02-21 | 德商安美基研究（慕尼黑）公司 | Ｄｌｌ３及ｃｄ３抗體構築體 |
| TWI717375B (zh) | 2015-07-31 | 2021-02-01 | 德商安美基研究（慕尼黑）公司 | Ｃｄ７０及ｃｄ３抗體構築體 |
| TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究（慕尼黑）公司 | Ｆｌｔ３及ｃｄ３抗體構築體 |
| TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究（慕尼黑）公司 | Egfrviii及cd3抗體構築體 |
| TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究（慕尼黑）公司 | Ｍｓｌｎ及ｃｄ３抗體構築體 |
| JP6940479B2 (ja) | 2015-08-03 | 2021-09-29 | ノバルティス アーゲー | Ｆｇｆ２１関連障害を処置する方法 |
| BR112018002427A8 (pt) | 2015-08-03 | 2022-10-18 | Tolero Pharmaceuticals Inc | Uso de alvocidib e de azacitidina ou decitabina para tratar câncer e kit e composição farmacêutica contendo as ditas substâncias |
| TW202340452A (zh) | 2015-08-04 | 2023-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
| PE20180802A1 (es) | 2015-08-05 | 2018-05-09 | Janssen Biotech Inc | Anticuerpos anti-cd154 y metodos de uso de estos |
| AU2016304588A1 (en) | 2015-08-06 | 2018-02-15 | Xoma (Us) Llc | Antibody fragments against the insulin receptor and uses thereof to treat hypoglycemia |
| US11661463B2 (en) | 2015-08-06 | 2023-05-30 | City Of Hope | Cell penetrating protein-antibody conjugates and methods of use |
| MA45352A (fr) | 2015-08-07 | 2018-06-13 | Univ Birmingham | Identification de glycopeptides associés à mhc de catégorie i comme cibles d'immunothérapie de cancer |
| CN105384825B (zh) | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
| PT3334761T (pt) | 2015-08-13 | 2023-08-17 | Univ New York | Moléculas baseadas em anticorpo seletivo para o epítopo {p}ser404 da tau e os seus usos no diagnóstico e tratamento de tauopatias |
| WO2017027685A2 (en) | 2015-08-13 | 2017-02-16 | New York University | Antibody-based molecules specific for the truncated asp421 epitope of tau and their uses in the diagnosis and treatment of tauopathy |
| PL3338094T3 (pl) | 2015-08-20 | 2019-09-30 | F. Hoffmann-La Roche Ag | Test immunologiczny oparty na cząstkach z zastosowaniem pegylowanego swoistego względem analitu czynnika wiążącego |
| KR20180054639A (ko) | 2015-08-28 | 2018-05-24 | 알렉터 엘엘씨 | 항-siglec-7 항체 및 이의 사용 방법 |
| EP4223784A3 (en) | 2015-09-02 | 2023-10-04 | The Regents of the University of Colorado, a body corporate | Compositions and methods for modulating t-cell mediated immune response |
| CN108350605A (zh) | 2015-09-04 | 2018-07-31 | 台湾浩鼎生技股份有限公司 | 聚糖阵列以及使用方法 |
| EP3842457A1 (en) | 2015-09-09 | 2021-06-30 | Novartis AG | Thymic stromal lymphopoietin (tslp)-binding molecules and methods of using the molecules |
| AU2016320748B2 (en) | 2015-09-09 | 2019-05-02 | Novartis Ag | Thymic stromal lymphopoietin (TSLP)-binding antibodies and methods of using the antibodies |
| AU2016323440B2 (en) | 2015-09-15 | 2023-07-13 | Amgen Inc. | Tetravalent bispecific and tetraspecific antigen binding proteins and uses thereof |
| MA44909A (fr) | 2015-09-15 | 2018-07-25 | Acerta Pharma Bv | Association thérapeutique d'un inhibiteur du cd19 et d'un inhibiteur de la btk |
| EP3349796A4 (en) | 2015-09-17 | 2019-05-29 | ImmunoGen, Inc. | THERAPEUTIC COMBINATIONS COMPRISING ANTI-FOLR1 IMMUNOCONJUGATES |
| EP3349797A4 (en) | 2015-09-18 | 2019-06-12 | The General Hospital Corporation Dba Massachusetts General Hospital | LOCALIZED DELIVERY OF ANTICHIMIOREPULSION AGENT FOR THE TREATMENT OF CANCER |
| EP3353196B1 (en) | 2015-09-22 | 2022-12-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Polypeptides capable of inhibiting the binding between leptin and neuropilin-1 |
| CN109071644B (zh) | 2015-09-23 | 2023-09-19 | 昂考梅德药品有限公司 | 治疗癌症的方法和组合物 |
| MX2018003633A (es) | 2015-09-25 | 2018-08-01 | Genentech Inc | Anticuerpos anti-tigit y metodos de uso. |
| EA201890790A1 (ru) | 2015-09-29 | 2018-10-31 | Селджин Корпорейшн | Связывающие pd-1 белки и способы их применения |
| JP2018529719A (ja) | 2015-09-30 | 2018-10-11 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | Ａｌｋ陰性がんを処置するためのｐｄ−１系結合アンタゴニストおよびａｌｋ阻害剤の組合せ |
| CN108368510B (zh) | 2015-09-30 | 2023-09-01 | 詹森生物科技公司 | 特异性结合人cd40的激动性抗体和使用方法 |
| AU2016332062A1 (en) | 2015-10-01 | 2018-04-26 | Amgen Inc. | Treatment of bile acid disorders |
| CN108431038A (zh) | 2015-10-06 | 2018-08-21 | 豪夫迈·罗氏有限公司 | 治疗多发性硬化的方法 |
| CA2997960A1 (en) | 2015-10-06 | 2017-04-13 | Alector Llc | Anti-trem2 antibodies and methods of use thereof |
| SG11201802881YA (en) | 2015-10-08 | 2018-05-30 | Oncotherapy Science Inc | Foxm1-derived peptide, and vaccine including same |
| US11161912B2 (en) | 2015-10-13 | 2021-11-02 | Technion Research & Development Foundation Limited | Heparanase-neutralizing monoclonal antibodies |
| WO2017066714A1 (en) | 2015-10-16 | 2017-04-20 | Compugen Ltd. | Anti-vsig1 antibodies and drug conjugates |
| US20180305458A1 (en) | 2015-10-16 | 2018-10-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases |
| IL295398A (en) | 2015-10-23 | 2022-10-01 | Eureka Therapeutics Inc | Antibody/t-cell receptor chimera structures and their uses |
| WO2017072757A1 (en) | 2015-10-25 | 2017-05-04 | Yeda Research And Development Co. Ltd. | Antibodies targeting quiescin sulfhydryl oxidase (qsox1) and uses of same |
| JP6931648B2 (ja) | 2015-10-27 | 2021-09-08 | ユーシービー バイオファルマ エスアールエル | 抗ｉｌ−１７ａ／ｆ抗体を用いた治療方法 |
| SG11201803567XA (en) | 2015-10-29 | 2018-05-30 | Alector Llc | Anti-siglec-9 antibodies and methods of use thereof |
| US10421821B2 (en) | 2015-10-30 | 2019-09-24 | Genentech, Inc. | Anti-HtrA1 antibodies and methods of use thereof |
| EP3370768B9 (en) | 2015-11-03 | 2022-03-16 | Janssen Biotech, Inc. | Antibodies specifically binding pd-1 and their uses |
| SI3374398T1 (sl) | 2015-11-10 | 2020-07-31 | Medimmune, Llc | Vezavne molekule, specifične za ASCT2 in njihove uporabe |
| US11213586B2 (en) | 2015-11-19 | 2022-01-04 | Bristol-Myers Squibb Company | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) |
| EP3377533A2 (en) | 2015-11-19 | 2018-09-26 | Sutro Biopharma, Inc. | Anti-lag3 antibodies, compositions comprising anti-lag3 antibodies and methods of making and using anti-lag3 antibodies |
| SG10201913538VA (en) | 2015-11-23 | 2020-02-27 | Five Prime Therapeutics Inc | Fgfr2 inhibitors alone or in combination with immune stimulating agents in cancer treatment |
| CN118105513A (zh) | 2015-11-25 | 2024-05-31 | 乐高化学生物科学股份有限公司 | 包含自降解基团的缀合物及其相关方法 |
| US10556948B2 (en) | 2015-11-30 | 2020-02-11 | Bristol-Myers Squibb Company | IP-10 antibodies and their uses |
| EP3383920B1 (en) | 2015-11-30 | 2024-01-10 | The Regents of the University of California | Tumor-specific payload delivery and immune activation using a human antibody targeting a highly specific tumor cell surface antigen |
| EP3176183A1 (en) | 2015-12-02 | 2017-06-07 | Yeda Research and Development Co. Ltd | Compositions and methods for treating cancer not resistant to a tyrosine kinase inhibitor (tki) |
| GB201521389D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Method |
| GB201521393D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
| GB201521383D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl And Ucb Celltech | Method |
| GB201521391D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
| GB201521382D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
| WO2017093985A1 (en) | 2015-12-05 | 2017-06-08 | Centre Hospitalier Universitaire Vaudois | Hiv binding agents |
| JP7080813B2 (ja) | 2015-12-10 | 2022-06-06 | シティ・オブ・ホープ | 細胞透過性のシアニド結合抗体 |
| MA43567A (fr) | 2015-12-15 | 2018-11-14 | Amgen Inc | Anticorps pacap et leurs utilisations |
| MA44072A (fr) | 2015-12-17 | 2018-10-24 | Janssen Biotech Inc | Anticorps se liant spécifiquement à hla-dr et leurs utilisations |
| US20170174788A1 (en) | 2015-12-17 | 2017-06-22 | Gilead Sciences, Inc. | Combination of a jak inhibitor and an mmp9 binding protein for treating inflammatory disorders |
| CN109069623A (zh) | 2015-12-18 | 2018-12-21 | 诺华股份有限公司 | 靶向CD32b的抗体及其使用方法 |
| WO2017106806A1 (en) | 2015-12-18 | 2017-06-22 | Federica Cavallo | COMPOSITIONS AND METHODS RELATED TO xCT PEPTIDES |
| TN2018000225A1 (en) | 2015-12-23 | 2019-10-04 | Amgen Inc | Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists |
| KR20180103918A (ko) | 2015-12-24 | 2018-09-19 | 코버스 파마슈티칼스, 인크. | 암을 치료하는 방법 |
| CN115400220A (zh) | 2015-12-30 | 2022-11-29 | 豪夫迈·罗氏有限公司 | 减少聚山梨酯降解的制剂 |
| CA3007491A1 (en) | 2015-12-30 | 2017-07-06 | Genentech, Inc. | Use of tryptophan derivatives for protein formulations |
| JP2019505511A (ja) | 2016-01-06 | 2019-02-28 | イェダ リサーチ アンド ディベロップメント カンパニー リミテッドＹｅｄａ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏ．Ｌｔｄ． | 悪性疾患、自己免疫疾患および炎症性疾患を処置するための組成物および方法 |
| US11103589B2 (en) | 2016-01-08 | 2021-08-31 | Apg Therapeutics, Inc. | Polyethylenimine (PEI)-polypeptide conjugates and methods of use thereof |
| JP7078536B2 (ja) | 2016-01-08 | 2022-05-31 | アルトゥルバイオ， インコーポレイテッド | 四価抗ｐｓｇｌ－１抗体とその使用 |
| KR20180097615A (ko) | 2016-01-08 | 2018-08-31 | 에프. 호프만-라 로슈 아게 | Pd-1 축 결합 길항물질 및 항-cea/항-cd3 이중특이성 항체를 사용하는 cea-양성 암의 치료 방법 |
| WO2017122203A1 (en) | 2016-01-11 | 2017-07-20 | Technion Research & Development Foundation Limited | Methods of determining prognosis of sepsis and treating same |
| US20190008869A1 (en) | 2016-01-13 | 2019-01-10 | Acerta Pharma B.V. | Therapeutic Combinations of an Antifolate and a BTK Inhibitor |
| WO2017125831A1 (en) | 2016-01-21 | 2017-07-27 | Pfizer Inc. | Mono and bispecific antibodies for epidermal growth factor receptor variant iii and cd3 and their uses |
| ES2847155T3 (es) | 2016-01-21 | 2021-08-02 | Novartis Ag | Moléculas multiespecíficas que fijan como objetivo CLL-1 |
| CN108699124A (zh) | 2016-01-21 | 2018-10-23 | 辉瑞大药厂 | 靶向表皮生长因子受体变体iii的嵌合抗原受体 |
| EP3964529A1 (en) | 2016-01-22 | 2022-03-09 | Mabquest SA | Non-blocking pd1 specific antibodies |
| US11214617B2 (en) | 2016-01-22 | 2022-01-04 | MabQuest SA | Immunological reagents |
| CN109073635A (zh) | 2016-01-25 | 2018-12-21 | 豪夫迈·罗氏有限公司 | 用于测定t细胞依赖性双特异性抗体的方法 |
| SG11201806419RA (en) | 2016-01-27 | 2018-08-30 | Sutro Biopharma Inc | Anti-cd74 antibody conjugates, compositions comprising anti-cd74 antibody conjugates and methods of using anti-cd74 antibody conjugates |
| US10918737B2 (en) | 2016-01-28 | 2021-02-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the treatment of cancer |
| US10822415B2 (en) | 2016-01-28 | 2020-11-03 | Inserm (Institut National De La Santéet De La Recherche Médicale) | Methods for enhancing the potency of the immune checkpoint inhibitors |
| WO2017129763A1 (en) | 2016-01-28 | 2017-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of signet ring cell gastric cancer |
| DK3411404T3 (da) | 2016-02-03 | 2023-01-30 | Amgen Res Munich Gmbh | Psma- og cd3-bispecifikke t-celleinddragende antistofkonstruktioner |
| WO2017136685A1 (en) | 2016-02-03 | 2017-08-10 | President And Fellows Of Harvard College | Methods of treating of inflammatory bowel disease and parasite infection |
| EA039859B1 (ru) | 2016-02-03 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
| CR20180420A (es) | 2016-02-03 | 2018-12-05 | Amgen Inc | Constructos de anticuerpo biespecíficos para bcma y cd3 que se ligan a células t |
| JP2019509721A (ja) | 2016-02-04 | 2019-04-11 | キュリス，インコーポレイテッド | 突然変異体スムースンド及びその使用方法 |
| CN108885210B (zh) | 2016-02-05 | 2022-07-19 | 纳诺韦尔生物科学有限公司 | 具有表面标记物的外来体的检测 |
| GB201602413D0 (en) | 2016-02-10 | 2016-03-23 | Nascient Ltd | Method |
| CA3014013A1 (en) | 2016-02-12 | 2017-08-17 | Janssen Pharmaceutica Nv | Anti-vista (b7h5) antibodies |
| WO2017138008A2 (en) | 2016-02-14 | 2017-08-17 | Yeda Research And Development Co. Ltd. | Methods of modulating protein exocytosis and uses of same in therapy |
| WO2017140684A2 (en) | 2016-02-15 | 2017-08-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction |
| EP3207937A1 (en) | 2016-02-17 | 2017-08-23 | Royal College of Surgeons in Ireland | A method of treating or preventing sepsis |
| US11730761B2 (en) | 2016-02-18 | 2023-08-22 | Enlivex Therapeutics Rdo Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US10941447B2 (en) | 2016-02-29 | 2021-03-09 | Rhode Island Hospital | Diagnostics for pulmonary arterial hypertension and sudden cardiac death |
| CN109196121B (zh) | 2016-02-29 | 2022-01-04 | 基因泰克公司 | 用于癌症的治疗和诊断方法 |
| EP4043492A1 (en) | 2016-03-01 | 2022-08-17 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Antibodies specific to human poliovirus receptor (pvr) |
| US11472877B2 (en) | 2016-03-04 | 2022-10-18 | Alector Llc | Anti-TREM1 antibodies and methods of use thereof |
| SG11201806861SA (en) | 2016-03-04 | 2018-09-27 | Bristol Myers Squibb Co | Combination therapy with anti-cd73 antibodies |
| US10894835B2 (en) | 2016-03-04 | 2021-01-19 | The Rockefeller University | Antibodies to CD40 with enhanced agonist activity |
| US20190216891A1 (en) | 2016-03-06 | 2019-07-18 | Yeda Research And Development Co., Ltd. | Method for modulating myelination |
| EP3426691A4 (en) | 2016-03-07 | 2019-09-25 | Charlestonpharma, LLC | ANTI-NUCLEOLIN ANTIBODIES |
| WO2017156192A1 (en) | 2016-03-08 | 2017-09-14 | Academia Sinica | Methods for modular synthesis of n-glycans and arrays thereof |
| KR102457751B1 (ko) | 2016-03-10 | 2022-10-21 | 악셀레론 파마 인코포레이티드 | 액티빈 타입 2 수용체 결합 단백질 및 이의 용도 |
| CA3016552A1 (en) | 2016-03-15 | 2017-09-21 | Genentech, Inc. | Methods of treating cancers using pd-1 axis binding antagonists and anti-gpc3 antibodies |
| CN109476756B (zh) | 2016-03-15 | 2022-05-31 | 埃泰美德(香港)有限公司 | 一种多特异性Fab融合蛋白及其用途 |
| HRP20220335T1 (hr) | 2016-03-15 | 2022-05-13 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Rani i neinvazivni postupak za procjenu rizika kod nekog subjekta od obolijevanja od duktalnog adenokarcinoma gušterače i postupci za liječenje takve bolesti |
| JP7137474B2 (ja) | 2016-03-15 | 2022-09-14 | メルサナ セラピューティクス，インコーポレイティド | ＮａＰｉ２ｂ標的化抗体－薬物コンジュゲート及びその使用方法 |
| WO2017158396A1 (en) | 2016-03-16 | 2017-09-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Cytidine deaminase inhibitors for the treatment of pancreatic cancer |
| KR102464372B1 (ko) | 2016-03-17 | 2022-11-04 | 세다르스-신나이 메디칼 센터 | Rnaset2를 통한 염증성 장 질환의 진단 방법 |
| EP3433615A1 (en) | 2016-03-21 | 2019-01-30 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Methods for diagnosis and treatment of solar lentigo |
| KR20220004226A (ko) | 2016-03-22 | 2022-01-11 | 바이오노믹스 리미티드 | 항-lgr5 단클론성 항체의 투여 |
| CN109311995A (zh) | 2016-03-29 | 2019-02-05 | 台湾浩鼎生技股份有限公司 | 抗体、药物组合物和方法 |
| WO2017172771A2 (en) | 2016-03-29 | 2017-10-05 | Janssen Biotech, Inc. | Method of treating psoriasis with increased interval dosing of anti-il12/23 antibody |
| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| WO2017173327A1 (en) | 2016-03-31 | 2017-10-05 | The Schepens Eye Research Institute, Inc. | Endomucin inhibitor as an anti-angiogenic agent |
| WO2017173302A2 (en) | 2016-04-01 | 2017-10-05 | The Regents Of The University Of California | Inhibitors of integrin alpha 5 beta 1 and methods of use |
| EP3439659A1 (en) | 2016-04-06 | 2019-02-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of age-related cardiometabolic diseases |
| WO2017175058A1 (en) | 2016-04-07 | 2017-10-12 | Janssen Pharmaceutica Nv | Anti-vista antibodies and fragments, uses thereof, and methods of identifying same |
| JP2019513737A (ja) | 2016-04-08 | 2019-05-30 | ギリアード サイエンシーズ， インコーポレイテッド | がん、炎症性疾患および自己免疫疾患を処置するための組成物および方法 |
| MA44776A (fr) | 2016-04-15 | 2019-03-06 | Immunext Inc | Anticorps anti-vista humain et leur utilisation |
| AU2017248766A1 (en) | 2016-04-15 | 2018-11-01 | Genentech, Inc. | Methods for monitoring and treating cancer |
| WO2017181111A2 (en) | 2016-04-15 | 2017-10-19 | Genentech, Inc. | Methods for monitoring and treating cancer |
| CA3021328A1 (en) | 2016-04-18 | 2017-10-26 | Celldex Therapeutics, Inc. | Agonistic antibodies that bind human cd40 and uses thereof |
| JOP20170091B1 (ar) | 2016-04-19 | 2021-08-17 | Amgen Res Munich Gmbh | إعطاء تركيبة ثنائية النوعية ترتبط بـ cd33 وcd3 للاستخدام في طريقة لعلاج اللوكيميا النخاعية |
| EP3445779A1 (en) | 2016-04-22 | 2019-02-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the treatment of inflammatory skin diseases associated with desmoglein-1 deficiency |
| AU2017252128B2 (en) | 2016-04-22 | 2024-06-06 | Obi Pharma, Inc. | Cancer immunotherapy by immune activation or immune modulation via Globo series antigens |
| EP3452512B1 (en) | 2016-05-03 | 2023-03-08 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods and pharmaceutical compositions for the treatment of tissue lesions |
| WO2017191300A1 (en) | 2016-05-06 | 2017-11-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Pharmaceutical compositions for the treatment of chemoresistant acute myeloid leukemia (aml) |
| CA3023678A1 (en) | 2016-05-09 | 2017-11-16 | Bristol-Myers Squibb Company | Tl1a antibodies and uses thereof |
| WO2017194554A1 (en) | 2016-05-10 | 2017-11-16 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Combinations therapies for the treatment of cancer |
| MX2018013683A (es) | 2016-05-10 | 2019-06-17 | Genentech Inc | Métodos para disminuir los enlaces de trisulfuro durante la producción recombinante de polipéptidos. |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| WO2017202962A1 (en) | 2016-05-24 | 2017-11-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of non small cell lung cancer (nsclc) that coexists with chronic obstructive pulmonary disease (copd) |
| IL245861A0 (en) | 2016-05-25 | 2016-09-04 | Yeda Res & Dev | Use of substances to treat drug-resistant tumors |
| SG11201810423XA (en) | 2016-05-26 | 2018-12-28 | Merck Patent Gmbh | Pd-1 / pd-l1 inhibitors for cancer treatment |
| KR20220119529A (ko) | 2016-06-02 | 2022-08-29 | 애브비 인코포레이티드 | 글루코코르티코이드 수용체 작용제 및 이의 면역접합체 |
| EP3463482B1 (en) | 2016-06-07 | 2021-10-06 | The Brigham and Women's Hospital, Inc. | Methods relating to t peripheral helper cells in autoantibody-associated conditions |
| WO2017218698A1 (en) | 2016-06-15 | 2017-12-21 | Sutro Biopharma, Inc. | Antibodies with engineered ch2 domains, compositions thereof and methods of using the same |
| EP3471759A1 (en) | 2016-06-15 | 2019-04-24 | Novartis AG | Methods for treating disease using inhibitors of bone morphogenetic protein 6 (bmp6) |
| CN109642900A (zh) | 2016-06-23 | 2019-04-16 | 米密德诊断学有限公司 | 通过侧流免疫测定测量trail |
| EP3478721A1 (en) | 2016-07-01 | 2019-05-08 | Five Prime Therapeutics, Inc. | Combined anti tumor therapy with a gitr agonist and cpg |
| JOP20180117B1 (ar) | 2016-07-12 | 2022-03-14 | H Lundbeck As | أجسام مضادة انتقائية لـ tau فائق المعالجة بفوسفوريلات وطرق لاستخدامها |
| SG10201911972QA (en) | 2016-07-14 | 2020-02-27 | Bristol Myers Squibb Co | Antibodies against tim3 and uses thereof |
| WO2018015881A1 (en) | 2016-07-18 | 2018-01-25 | Ramot At Tel-Aviv University Ltd. | Modular platform for targeted therapeutics |
| WO2018014260A1 (en) | 2016-07-20 | 2018-01-25 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
| CA3031469A1 (en) | 2016-07-22 | 2018-01-25 | Amgen Inc. | Methods of purifying fc-containing proteins |
| KR102534568B1 (ko) | 2016-07-22 | 2023-05-18 | 다나-파버 캔서 인스티튜트 인크. | 글루코코르티코이드-유도된 종양 괴사 인자 수용체 (gitr) 항체 및 이의 이용 방법 |
| JP2019527690A (ja) | 2016-07-27 | 2019-10-03 | オービーアイ ファーマ，インコーポレイテッド | 免疫原性／治療用グリカン組成物およびその使用 |
| JP2019528437A (ja) | 2016-07-28 | 2019-10-10 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 腫瘍関連マクロファージをターゲティングすることによるガン疾患の処置方法 |
| EP3491026A4 (en) | 2016-07-29 | 2020-07-29 | OBI Pharma, Inc. | HUMAN ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND METHODS |
| US10519250B2 (en) | 2016-08-01 | 2019-12-31 | Xoma (Us) Llc | Parathyroid hormone receptor 1 (PTH1R) antibodies and uses thereof |
| WO2018027124A1 (en) | 2016-08-05 | 2018-02-08 | Medimmune, Llc | Anti-o2 antibodies and uses thereof |
| US11878060B2 (en) | 2016-08-07 | 2024-01-23 | Novartis Ag | mRNA-mediated immunization methods |
| WO2018029124A1 (en) | 2016-08-08 | 2018-02-15 | F. Hoffmann-La Roche Ag | Therapeutic and diagnostic methods for cancer |
| EP3497112A1 (en) | 2016-08-12 | 2019-06-19 | Bristol-Myers Squibb Company | Methods of purifying proteins |
| EP3497120A1 (en) | 2016-08-12 | 2019-06-19 | Janssen Biotech, Inc. | Engineered antibodies and other fc-domain containing molecules with enhanced agonism and effector functions |
| AU2017308734A1 (en) | 2016-08-12 | 2019-02-14 | Janssen Biotech, Inc. | Fc engineered anti-TNFR superfamily member antibodies having enhanced agonistic activity and methods of using them |
| MX2019001635A (es) | 2016-08-12 | 2019-06-10 | Genentech Inc | Terapia de combinacion con un inhibidor de mek, un inhibidor del eje de pd-1, y un inhibidor de vegf. |
| KR102617148B1 (ko) | 2016-08-15 | 2023-12-26 | 제넨테크, 인크. | 비이온성 계면활성제 및 폴리펩티드를 포함하는 조성물에서 비이온성 계면활성제를 정량화하기 위한 크로마토그래피 방법 |
| TWI764917B (zh) | 2016-08-22 | 2022-05-21 | 醣基生醫股份有限公司 | 抗體、結合片段及使用方法 |
| WO2018044970A1 (en) | 2016-08-31 | 2018-03-08 | University Of Rochester | Human monoclonal antibodies to human endogenous retrovirus k envelope (herv-k) and uses thereof |
| CA3035081A1 (en) | 2016-09-02 | 2018-03-08 | Dana-Farber Cancer Institute, Inc. | Composition and methods of treating b cell disorders |
| MX2019002696A (es) | 2016-09-06 | 2019-09-27 | Dana Farber Cancer Inst Inc | Metodos para tratar o prevenir una infeccion del virus del zika. |
| EP3510046A4 (en) | 2016-09-07 | 2020-05-06 | The Regents of the University of California | ANTIBODIES AGAINST OXIDATION-SPECIFIC EPITOPES |
| EP3510047A1 (en) | 2016-09-07 | 2019-07-17 | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. | Anti-nkp46 antibodies and therapeutic use of same |
| TW201825511A (zh) | 2016-09-09 | 2018-07-16 | 美商艾斯合顧問有限公司 | 表現免疫檢查點調節子的溶瘤病毒 |
| WO2018053142A2 (en) | 2016-09-14 | 2018-03-22 | President And Fellows Of Harvard College | Methods and compositions for modulating erythropoiesis |
| EP4339615A3 (en) | 2016-09-16 | 2024-05-22 | Shanghai Henlius Biotech, Inc. | Anti-pd-1 antibodies |
| MX2019002867A (es) | 2016-09-19 | 2019-11-12 | Celgene Corp | Metodos de tratamiento de trastornos inmunologicos usando proteinas de union a pd-1. |
| WO2018053401A1 (en) | 2016-09-19 | 2018-03-22 | Celgene Corporation | Methods of treating vitiligo using pd-1 binding proteins |
| JOP20190009A1 (ar) | 2016-09-21 | 2019-01-27 | Alx Oncology Inc | أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها |
| EP3515937A1 (en) | 2016-09-23 | 2019-07-31 | Teva Pharmaceuticals International GmbH | Treating refractory migraine |
| JP2019529463A (ja) | 2016-09-23 | 2019-10-17 | テバ・ファーマシューティカルズ・インターナショナル・ゲー・エム・ベー・ハー | 群発頭痛の治療方法 |
| MX2019003543A (es) | 2016-09-28 | 2019-06-17 | Xoma Us Llc | Anticuerpos que se fijan al interleucina-2 y sus usos. |
| GB201616596D0 (en) | 2016-09-29 | 2016-11-16 | Nascient Limited | Epitope and antibodies |
| WO2018064478A1 (en) | 2016-09-29 | 2018-04-05 | The Regents Of The University Of California | NEUTRALIZING ANTIBODIES TO THE αVβ8 INTEGRIN COMPLEX FOR IMMUNOTHERAPY |
| CA3038671A1 (en) | 2016-09-29 | 2018-04-05 | Genentech, Inc. | Combination therapy with a mek inhibitor, a pd-1 axis inhibitor, and a taxane |
| MX2019003703A (es) | 2016-09-30 | 2020-08-13 | Janssen Biotech Inc | Método seguro y eficaz para tratar la psoriasis con el anticuerpo específico anti-il23. |
| FR3056912B1 (fr) | 2016-09-30 | 2019-12-27 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Procede d'inactivation virale d'une preparation d'anticorps monoclonaux |
| CN110418851A (zh) | 2016-10-06 | 2019-11-05 | 基因泰克公司 | 癌症的治疗和诊断方法 |
| AU2017339856A1 (en) | 2016-10-06 | 2019-05-23 | Merck Patent Gmbh | Dosing regimen of avelumab for the treatment of cancer |
| WO2018068201A1 (en) | 2016-10-11 | 2018-04-19 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against ctla-4 |
| WO2018071597A1 (en) | 2016-10-12 | 2018-04-19 | Sutro Biopharma, Inc. | Anti-folate receptor antibodies, compositions comprising anti-folate receptor antibodies and methods of making and using anti-folate receptor antibodies |
| US10829545B2 (en) | 2016-10-13 | 2020-11-10 | Massachusetts Institute Of Technology | Antibodies that bind Zika virus envelope protein and uses thereof |
| US11117956B2 (en) | 2016-10-19 | 2021-09-14 | Medimmune, Llc | Anti-O1 antibodies and uses thereof |
| US11365257B2 (en) | 2016-10-21 | 2022-06-21 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for promoting t cells response by administering an antagonist of human c-type lectin-like receptor 1 (CLEC-1) |
| CN118240830A (zh) | 2016-10-26 | 2024-06-25 | 西达-赛奈医疗中心 | 中和抗tl1a单克隆抗体 |
| WO2018081531A2 (en) | 2016-10-28 | 2018-05-03 | Ariad Pharmaceuticals, Inc. | Methods for human t-cell activation |
| WO2018083258A1 (en) | 2016-11-03 | 2018-05-11 | Psioxus Therapeutics Limited | Oncolytic adenovirus encoding at least three transgenes |
| WO2018083257A1 (en) | 2016-11-03 | 2018-05-11 | Psioxus Therapeutics Limited | Oncolytic adenovirus encoding transgenes |
| WO2018083248A1 (en) | 2016-11-03 | 2018-05-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| EP3535299A1 (en) | 2016-11-04 | 2019-09-11 | Novimmune S.A. | Anti-cd19 antibodies and methods of use thereof |
| MA46753A (fr) | 2016-11-14 | 2019-09-18 | Amgen Inc | Protéines de liaison à l'antigène bispécifiques ou biparatopiques et utilisations de celles-ci |
| US11008325B2 (en) | 2016-11-14 | 2021-05-18 | Virginia Commonwealth University | Inhibitors of cancer invasion, attachment, and/or metastasis |
| EP3538546A1 (en) | 2016-11-14 | 2019-09-18 | Novartis AG | Compositions, methods, and therapeutic uses related to fusogenic protein minion |
| BR112018014281A2 (pt) | 2016-11-15 | 2018-12-18 | H Lundbeck As | agentes, usos e métodos para o tratamento da sinucleinopatia |
| US11229662B2 (en) | 2016-11-15 | 2022-01-25 | The Schepens Eye Research Institute, Inc. | Compositions and methods for the treatment of aberrant angiogenesis |
| MA46861A (fr) | 2016-11-16 | 2019-09-25 | Janssen Biotech Inc | Procédé de traitement du psoriasis avec un anticorps anti-il-23 spécifique |
| WO2018094275A1 (en) | 2016-11-18 | 2018-05-24 | Tolero Pharmaceuticals, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
| JOP20190100A1 (ar) | 2016-11-19 | 2019-05-01 | Potenza Therapeutics Inc | بروتينات ربط مولد ضد مضاد لـ gitr وطرق استخدامها |
| JP2019535731A (ja) | 2016-11-21 | 2019-12-12 | オービーアイ ファーマ，インコーポレイテッド | コンジュゲートさせた生物学的分子、医薬組成物及び方法 |
| EP3544601B1 (en) | 2016-11-23 | 2024-03-20 | Translational Drug Development, LLC | A composition comprising a benzamide and a tnfrsf agonist binding to 4-1bb or gitr, and the use thereof in the treatment of cancer. |
| WO2018112032A1 (en) | 2016-12-13 | 2018-06-21 | President And Fellows Of Harvard College | Methods and compositions for targeting tumor-infiltrating tregs using inhibitors of ccr8 and tnfrsf8 |
| FR3060394B1 (fr) | 2016-12-16 | 2019-05-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Combinaison d'anticorps anti-cd303 et anti-amhrii |
| WO2018112360A1 (en) | 2016-12-16 | 2018-06-21 | Evelo Biosciences, Inc. | Combination therapies for treating cancer |
| FR3060395B1 (fr) | 2016-12-16 | 2019-05-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Combinaison d'anticorps anti-cd303 et anti-her2 |
| WO2018112364A1 (en) | 2016-12-16 | 2018-06-21 | Evelo Biosciences, Inc. | Combination therapies for treating melanoma |
| WO2018109058A1 (en) | 2016-12-16 | 2018-06-21 | H. Lundbeck A/S | Agents, uses and methods |
| JP6619519B2 (ja) | 2016-12-19 | 2019-12-11 | トレロ ファーマシューティカルズ， インコーポレイテッド | プロファイリングペプチドおよび感受性プロファイリングのための方法 |
| GB201621635D0 (en) | 2016-12-19 | 2017-02-01 | Ucb Biopharma Sprl | Crystal structure |
| US10364286B2 (en) | 2016-12-22 | 2019-07-30 | H. Lundbeck A/S | Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation |
| WO2018119380A2 (en) | 2016-12-23 | 2018-06-28 | Bristol-Myers Squibb Company | Design of therapeutic immunoglobulin g4 for improved bioanalytical and bioprocessing properties |
| JOP20190134A1 (ar) | 2016-12-23 | 2019-06-02 | Potenza Therapeutics Inc | بروتينات رابطة لمولد ضد مضادة لنيوروبيلين وطرق استخدامها |
| CN110088139A (zh) | 2016-12-27 | 2019-08-02 | 豪夫迈·罗氏有限公司 | 新的生物素特异性单克隆抗体及其用途 |
| EP3562841A1 (en) | 2016-12-27 | 2019-11-06 | H. Hoffnabb-La Roche Ag | Novel biotin-specific monoclonal antibody and use thereof |
| KR102413013B1 (ko) | 2016-12-27 | 2022-06-23 | 에프. 호프만-라 로슈 아게 | 신규한 비오틴-특이적 단일클론 항체 및 그 용도 |
| KR102085798B1 (ko) | 2016-12-28 | 2020-03-06 | 주식회사 인투셀 | 베타-갈락토사이드가 도입된 자가-희생 기를 포함하는 화합물 |
| WO2018122249A1 (en) | 2016-12-28 | 2018-07-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival time of patients suffering from a microsatellite stable colorectal cancer |
| WO2018122245A1 (en) | 2016-12-28 | 2018-07-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting the survival time of patients suffering from cms3 colorectal cancer |
| AU2017388556B2 (en) | 2016-12-29 | 2020-06-25 | Development Center For Biotechnology | Processes for preparing glycoprotein-drug conjugates |
| MA47205A (fr) | 2017-01-04 | 2019-11-13 | H Lundbeck As | Anticorps spécifiques de la protéine tau hyperphosphorylée pour traiter des maladies oculaires |
| WO2018129039A1 (en) | 2017-01-04 | 2018-07-12 | President And Fellows Of Harvard College | Modulating nudix homology domain (nhd) with nicotinamide mononucleotide analogs and derivatives of same |
| WO2018128454A1 (ko) | 2017-01-06 | 2018-07-12 | 에이비엘바이오 주식회사 | 항 α-SYN 항체 및 그 용도 |
| TW201833140A (zh) | 2017-01-09 | 2018-09-16 | 美商莫瑞麥克製藥公司 | 抗fgfr抗體及使用方法 |
| EP3568468A4 (en) | 2017-01-12 | 2020-12-30 | Eureka Therapeutics, Inc. | RECOMBINATION PRODUCTS TARGETING PEPTIDE HISTONE H3 / MHC COMPLEXES AND THEIR USES |
| JOP20190177A1 (ar) | 2017-01-17 | 2019-07-16 | Amgen Inc | طريقة لعلاج أو تحسين اضطرابات أيضية باستخدام مساعدات مستقبل glp-1 مقترنة بمناهضات لمستقبل ببتيد مثبط معوي (gipr) |
| SG11201906540WA (en) | 2017-01-19 | 2019-08-27 | Open Monoclonal Tech Inc | Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci |
| MX2019008989A (es) | 2017-01-30 | 2019-10-09 | Janssen Biotech Inc | Anticuerpos anti-tnf, composiciones y metodos para el tratamiento de la artritis psoriasica activa. |
| JOP20190189A1 (ar) | 2017-02-02 | 2019-08-01 | Amgen Res Munich Gmbh | تركيبة صيدلانية ذات درجة حموضة منخفضة تتضمن بنيات جسم مضاد يستهدف الخلية t |
| ES2865511T3 (es) | 2017-02-02 | 2021-10-15 | Hoffmann La Roche | Inmunoanálisis que usa al menos dos agentes de unión específica a analito pegilado |
| AU2017398101A1 (en) | 2017-02-07 | 2019-08-01 | Janssen Biotech, Inc. | Anti-TNF antibodies, compositions, and methods for the treatment of active Ankylosing Spondylitis |
| IL292067B2 (en) | 2017-02-08 | 2024-01-01 | Novartis Ag | Anti-FGF21 mimetic antibodies and their use |
| EP3579872A1 (en) | 2017-02-10 | 2019-12-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway |
| EA201991720A1 (ru) | 2017-02-17 | 2020-01-20 | Бристол-Маерс Сквибб Компани | Антитела к альфа-синуклеину и их применения |
| WO2018152496A1 (en) | 2017-02-17 | 2018-08-23 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Compositions and methods for the diagnosis and treatment of zika virus infection |
| CN108456251A (zh) | 2017-02-21 | 2018-08-28 | 上海君实生物医药科技股份有限公司 | 抗pd-l1抗体及其应用 |
| WO2018156777A1 (en) | 2017-02-22 | 2018-08-30 | Sutro Biopharma, Inc. | Pd-1/tim-3 bi-specific antibodies, compositions thereof, and methods of making and using the same |
| JP7256127B2 (ja) | 2017-03-01 | 2023-04-11 | ジェネンテック， インコーポレイテッド | がんのための診断及び治療方法 |
| KR20190133174A (ko) | 2017-03-02 | 2019-12-02 | 베쓰 이스라엘 디코니스 메디칼 센터 인크 | 칼시토닌 유전자 관련 펩티드에 대해 지시되는 항체에 반응하는 두통 환자를 선택하는 방법 |
| WO2018167283A1 (en) | 2017-03-17 | 2018-09-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma associated neural remodeling |
| AU2018240117A1 (en) | 2017-03-24 | 2019-09-19 | Beth Israel Deaconess Medical Center, Inc. | Methods for preventing and treating heart disease |
| JOP20190203A1 (ar) | 2017-03-30 | 2019-09-03 | Potenza Therapeutics Inc | بروتينات رابطة لمولد ضد مضادة لـ tigit وطرق استخدامها |
| US11359005B2 (en) | 2017-03-30 | 2022-06-14 | The Johns Hopkins University | Supramolecular high affinity protein-binding system for purification of biomacromolecules |
| SG11201909064RA (en) | 2017-03-30 | 2019-10-30 | Merck Patent Gmbh | Combination of an anti-pd-l1 antibody and a dna-pk inhibitor for the treatment of cancer |
| EP3601353A1 (en) | 2017-03-31 | 2020-02-05 | Five Prime Therapeutics, Inc. | Combination therapy for cancer using anti-gitr antibodies |
| WO2018185516A1 (en) | 2017-04-05 | 2018-10-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cardiovascular toxicity induced by anti-cancer therapy |
| TWI788340B (zh) | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | 抗icos促效劑抗體及其用途 |
| JOP20190243A1 (ar) | 2017-04-12 | 2019-10-13 | Medimmune Llc | علاج الربو بجسم مضاد لـ tslp |
| WO2018189335A1 (en) | 2017-04-13 | 2018-10-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma |
| CA3058282A1 (en) | 2017-04-14 | 2018-10-18 | Gamamabs Pharma | Amhrii-binding compounds for preventing or treating cancers |
| MX2019012136A (es) | 2017-04-14 | 2020-07-20 | Gamamabs Pharma | Compuestos de union al receptor de la hormona antimulleriana tipo ii (amhrii) para prevenir o tratar canceres de pulmon. |
| WO2018189403A1 (en) | 2017-04-14 | 2018-10-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of cancer |
| RU2665790C1 (ru) | 2017-04-17 | 2018-09-04 | Закрытое Акционерное Общество "Биокад" | Моноклональное антитело к pd-l1 |
| JOP20180042A1 (ar) | 2017-04-24 | 2019-01-30 | Kite Pharma Inc | نطاقات ربط مولد ضد متوافقة مع البشر وطرق الاستخدام |
| US11236151B2 (en) | 2017-04-25 | 2022-02-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibodies and methods for the diagnosis and treatment of Epstein Barr virus infection |
| AU2018258049A1 (en) | 2017-04-26 | 2019-12-12 | Eureka Therapeutics, Inc. | Constructs specifically recognizing glypican 3 and uses thereof |
| SG10201913656TA (en) | 2017-04-26 | 2020-03-30 | Eureka Therapeutics Inc | Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof |
| CN110913904A (zh) | 2017-05-05 | 2020-03-24 | 美国安进公司 | 用于改善的储存和施用的包含双特异性抗体构建体的药物组合物 |
| IL252151A0 (en) | 2017-05-07 | 2017-07-31 | Fainzilber Michael | Treatment of stress disorders |
| EP3621991A2 (en) | 2017-05-10 | 2020-03-18 | Ariel Scientific Innovations Ltd. | Methods of purifying antibodies |
| WO2018213316A1 (en) | 2017-05-16 | 2018-11-22 | Alector Llc | Anti-siglec-5 antibodies and methods of use thereof |
| CA3062177A1 (en) | 2017-05-16 | 2018-11-22 | Five Prime Therapeutics, Inc. | Anti-fgfr2 antibodies in combination with chemotherapy agents in cancer treatment |
| ES2939298T3 (es) | 2017-05-21 | 2023-04-20 | Medical Res Infrastructure & Health Services Fund Tel Aviv Medical Ct | Combinación de marcadores para el diagnóstico del cáncer |
| US10914729B2 (en) | 2017-05-22 | 2021-02-09 | The Trustees Of Princeton University | Methods for detecting protein binding sequences and tagging nucleic acids |
| US20200172604A1 (en) | 2017-05-23 | 2020-06-04 | Technion Research & Development Foundation Limited | Agents which inhibit gads dimerization and methods of use thereof |
| WO2018217940A2 (en) | 2017-05-24 | 2018-11-29 | Sutro Biopharma, Inc. | Pd-1/lag3 bi-specific antibodies, compositions thereof, and methods of making and using the same |
| US11260117B2 (en) | 2017-05-26 | 2022-03-01 | Novimmune Sa | Anti-CD47 x anti-mesothelin antibodies and methods of use thereof |
| JOP20190259A1 (ar) | 2017-05-31 | 2019-10-31 | Amgen Inc | بروتينات ربط مولد ضد مضادة لـ jagged1 |
| HUE063274T2 (hu) | 2017-06-01 | 2024-01-28 | Akamis Bio Ltd | Onkolitikus vírus és eljárás |
| PE20191846A1 (es) | 2017-06-02 | 2019-12-31 | Pfizer | Anticuerpos especificos para flt3 y sus usos |
| AU2018278321A1 (en) | 2017-06-02 | 2019-11-21 | Pfizer Inc. | Chimeric antigen receptors targeting FLT3 |
| US11149094B2 (en) | 2017-06-05 | 2021-10-19 | Janssen Biotech, Inc. | Engineered multispecific antibodies and other multimeric proteins with asymmetrical CH2-CH3 region mutations |
| WO2018226580A2 (en) | 2017-06-05 | 2018-12-13 | Janssen Biotech, Inc. | Antibodies that specifically bind pd-1 and methods of use |
| EP3612192A4 (en) | 2017-06-08 | 2020-05-27 | Enlivex Therapeutics Ltd. | THERAPEUTIC APOPTOSE CELLS FOR CANCER THERAPY |
| WO2018229715A1 (en) | 2017-06-16 | 2018-12-20 | Novartis Ag | Compositions comprising anti-cd32b antibodies and methods of use thereof |
| US20210087286A1 (en) | 2017-06-20 | 2021-03-25 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists |
| US20210403573A1 (en) | 2017-06-22 | 2021-12-30 | INSERM (Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical compositions for the treatment of fibrosis with agents capable of inhibiting the activation of mucosal-associated invariant t (mait) cells |
| WO2019000223A1 (en) | 2017-06-27 | 2019-01-03 | Nanjing Legend Biotech Co., Ltd. | ENABLERS OF IMMUNE EFFECTOR CELLS OF CHIMERIC ANTIBODIES AND METHODS OF USE THEREOF |
| TW201906865A (zh) | 2017-06-28 | 2019-02-16 | 瑞士商諾華公司 | 預防及治療尿失禁之方法 |
| US20210145828A1 (en) | 2017-06-29 | 2021-05-20 | Rutgers, The State University Of New Jersey | Compositions And Methods Targeting G12 Signaling For Bronchodilator Therapy |
| CN111032694B (zh) | 2017-07-14 | 2024-03-08 | 辉瑞大药厂 | 针对madcam的抗体 |
| WO2019018629A1 (en) | 2017-07-19 | 2019-01-24 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | ANTIBODIES AND METHODS FOR DIAGNOSING AND TREATING INFECTION WITH HEPATITIS B VIRUS |
| US10894833B2 (en) | 2017-07-20 | 2021-01-19 | H. Lundbeck A/S | Agents, uses and methods for treatment |
| US20190048073A1 (en) | 2017-07-20 | 2019-02-14 | Pfizer Inc. | Anti-gd3 antibodies and antibody-drug conjugates |
| CA3069469A1 (en) | 2017-07-21 | 2019-01-24 | Genentech, Inc. | Therapeutic and diagnostic methods for cancer |
| WO2019020593A1 (en) | 2017-07-25 | 2019-01-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR MODULATION OF MONOCYTOPOISIS |
| EP3658588A1 (en) | 2017-07-26 | 2020-06-03 | Sutro Biopharma, Inc. | Methods of using anti-cd74 antibodies and antibody conjugates in treatment of t-cell lymphoma |
| MX2020000957A (es) | 2017-07-26 | 2020-07-22 | Forty Seven Inc | Anticuerpos anti-sirp-alfa y metodos relacionados. |
| MA47691A (fr) | 2017-08-03 | 2020-01-08 | Alector Llc | Anticorps anti-cd33 et leurs procédés d'utilisation |
| BR112019022752A2 (pt) | 2017-08-03 | 2020-05-19 | Alector Llc | anticorpos anti-trem2 e métodos de uso dos mesmos |
| JP7504025B2 (ja) | 2017-08-04 | 2024-06-21 | アムジエン・インコーポレーテツド | Ｃｙｓ－ｍａｂのコンジュゲーション方法 |
| US20200256880A1 (en) | 2017-08-16 | 2020-08-13 | The Broad Institute, Inc. | Neuronal Assay Method Involving Calcineurin |
| US11745165B2 (en) | 2017-08-18 | 2023-09-05 | The Johns Hopkins University | Supramolecular filamentous assemblies for protein purification |
| WO2019036842A1 (en) | 2017-08-21 | 2019-02-28 | Adagene Inc. | DYNAMIC LIBRARIES OF HUMAN HEAVY CHAIN ANTIBODIES |
| JP7324744B2 (ja) | 2017-08-21 | 2023-08-10 | アダジーン インコーポレイテッド | ダイナミックヒト抗体軽鎖ライブラリー |
| WO2019055579A1 (en) | 2017-09-12 | 2019-03-21 | Tolero Pharmaceuticals, Inc. | TREATMENT REGIME FOR CANCERS THAT ARE INSENSITIVE TO BCL-2 INHIBITORS USING THE MCL-1 ALVOCIDIB INHIBITOR |
| WO2019055537A1 (en) | 2017-09-13 | 2019-03-21 | Five Prime Therapeutics, Inc. | ANTI-CSF1R AND ANTI-PD -1 ANTIBODY POLYTHERAPY FOR PANCREATIC CANCER |
| WO2019055909A1 (en) | 2017-09-18 | 2019-03-21 | Sutro Biopharma, Inc. | ALPHA ANTI-FOLATE ANTIBODY-RECEPTOR CONJUGATES AND USES THEREOF |
| WO2019059411A1 (en) | 2017-09-20 | 2019-03-28 | Chugai Seiyaku Kabushiki Kaisha | DOSAGE FOR POLYTHERAPY USING PD-1 AXIS BINDING ANTAGONISTS AND GPC3 TARGETING AGENT |
| JP7330174B2 (ja) | 2017-09-20 | 2023-08-21 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | オートファジーをモジュレーションするための方法及び医薬組成物 |
| CN111133001B (zh) | 2017-09-22 | 2024-02-06 | 豪夫迈·罗氏有限公司 | 用于分析目的的多价单或双特异性重组抗体 |
| TW201922780A (zh) | 2017-09-25 | 2019-06-16 | 美商健生生物科技公司 | 以抗ｉｌ１２／ｉｌ２３抗體治療狼瘡之安全且有效之方法 |
| US10610585B2 (en) | 2017-09-26 | 2020-04-07 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and compositions for treating and preventing HIV |
| US20200354452A1 (en) | 2017-09-29 | 2020-11-12 | City Of Hope | Cars and bispecific antibodies for treatment of mantle cell lymphoma |
| RU2698048C2 (ru) | 2017-10-03 | 2019-08-21 | Закрытое Акционерное Общество "Биокад" | МОНОКЛОНАЛЬНОЕ АНТИТЕЛО К IL-5Rα |
| EA039662B1 (ru) | 2017-10-03 | 2022-02-24 | Закрытое Акционерное Общество "Биокад" | Антитела, специфичные к cd47 и pd-l1 |
| CN111372950A (zh) | 2017-10-12 | 2020-07-03 | 免疫苏醒公司 | Vegfr-抗体轻链融合蛋白 |
| WO2019083904A1 (en) | 2017-10-23 | 2019-05-02 | Chan Zuckerberg Biohub, Inc. | AFUCOSYLATED IGG FC GLYCANES MEASUREMENT AND METHODS OF TREATMENT THEREOF |
| EP3700933A1 (en) | 2017-10-25 | 2020-09-02 | Novartis AG | Antibodies targeting cd32b and methods of use thereof |
| EP3700567A4 (en) | 2017-10-26 | 2021-09-29 | The Regents of The University of California | INHIBITION OF OXIDATION SPECIFIC EPITOPES FOR TREATMENT OF ISCHEMIC REPERFUSION DAMAGE |
| CN111886015B (zh) | 2017-10-31 | 2024-04-26 | 艾洛基治疗公司 | 用于同种异体嵌合抗原受体t细胞的给药的方法和组合物 |
| CN111213059B (zh) | 2017-11-06 | 2024-01-09 | 豪夫迈·罗氏有限公司 | 用于癌症的诊断和治疗方法 |
| WO2019099560A1 (en) | 2017-11-14 | 2019-05-23 | The Schepens Eye Research Institute, Inc. | Runx1 inhibition for treatment of proliferative vitreoretinopathy and conditions associated with epithelial to mesenchymal transition |
| MA50102A (fr) | 2017-11-14 | 2020-07-15 | Univ Virginia Patent Foundation | Compositions et méthodes de fabrication et d'utilisation d'anticorps bispécifiques |
| IL255664A0 (en) | 2017-11-14 | 2017-12-31 | Shachar Idit | Hematopoietic stem cells with enhanced properties |
| WO2019101995A1 (en) | 2017-11-27 | 2019-05-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for cardiac regeneration |
| CN111727075B (zh) | 2017-11-27 | 2024-04-05 | 普渡制药公司 | 靶向人组织因子的人源化抗体 |
| EP3716994A4 (en) | 2017-11-29 | 2021-09-01 | Board of Regents of the University of Texas System | COMPOSITIONS AND METHODS FOR CARCINOTHERAPY |
| ES2877659T3 (es) | 2017-12-01 | 2021-11-17 | Abbvie Inc | Agonista del receptor de glucocorticoides y sus inmunoconjugados |
| WO2019109016A1 (en) | 2017-12-01 | 2019-06-06 | Millennium Pharmaceuticals, Inc. | Biomarkers and methods for treatment with nae inhibitors |
| WO2019106126A1 (en) | 2017-12-01 | 2019-06-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Mdm2 modulators for the diagnosis and treatment of liposarcoma |
| EP3724229A1 (en) | 2017-12-11 | 2020-10-21 | Amgen Inc. | Continuous manufacturing process for bispecific antibody products |
| EP3498293A1 (en) | 2017-12-15 | 2019-06-19 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Treatment of monogenic diseases with an anti-cd45rc antibody |
| WO2019116096A1 (en) | 2017-12-15 | 2019-06-20 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Production of fc fragments |
| PE20201339A1 (es) | 2017-12-19 | 2020-11-25 | Univ Rockefeller | Variantes de dominio de fc de igg humana con funcion efectora mejorada |
| SG11202005692WA (en) | 2017-12-20 | 2020-07-29 | Harbour Biomed Shanghai Co Ltd | Antibodies binding ctla-4 and uses thereof |
| WO2019121872A1 (en) | 2017-12-20 | 2019-06-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of liver cancer |
| WO2019129211A1 (en) | 2017-12-28 | 2019-07-04 | Nanjing Legend Biotech Co., Ltd. | Antibodies and variants thereof against pd-l1 |
| CA3082280A1 (en) | 2017-12-28 | 2019-07-04 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against tigit |
| FR3076294B1 (fr) | 2017-12-29 | 2022-01-28 | Lab Francais Du Fractionnement | Procede de purification d'anticorps a partir de lait brut |
| CN111886246A (zh) | 2017-12-29 | 2020-11-03 | 艾莱克特有限责任公司 | 抗tmem106b抗体及其使用方法 |
| TW201940518A (zh) | 2017-12-29 | 2019-10-16 | 美商安進公司 | 針對ｍｕｃ１７和ｃｄ３之雙特異性抗體構建體 |
| SG11202006400UA (en) | 2018-01-04 | 2020-08-28 | Iconic Therapeutics Inc | Anti-tissue factor antibodies, antibody-drug conjugates, and related methods |
| EP3737700A1 (en) | 2018-01-12 | 2020-11-18 | Bristol-Myers Squibb Company | Antibodies against tim3 and uses thereof |
| US10738110B2 (en) | 2018-01-12 | 2020-08-11 | Amgen Inc. | PAC1 antibodies and uses thereof |
| EP3737696A1 (en) | 2018-01-12 | 2020-11-18 | Bristol-Myers Squibb Company | Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer |
| WO2019137541A1 (en) | 2018-01-15 | 2019-07-18 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against pd-1 |
| US20190225689A1 (en) | 2018-01-22 | 2019-07-25 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-pd-1 antibodies |
| CN111954541A (zh) | 2018-01-25 | 2020-11-17 | Acm生物实验室私人有限公司 | 包含可溶性包封抗原的聚合物囊泡以及其制备方法和用途 |
| EP3743096A1 (en) | 2018-01-25 | 2020-12-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antagonists of il-33 for use in methods for preventing ischemia reperfusion injury in an organ |
| JP7268038B2 (ja) | 2018-01-31 | 2023-05-02 | アレクトル エルエルシー | 抗ｍｓ４ａ４ａ抗体及びその使用方法 |
| CA3089318A1 (en) | 2018-02-01 | 2019-08-08 | Pfizer Inc. | Chimeric antigen receptors targeting cd70 |
| CA3090032A1 (en) | 2018-02-01 | 2019-08-08 | Pfizer Inc. | Antibodies specific for cd70 and their uses |
| WO2019150309A1 (en) | 2018-02-02 | 2019-08-08 | Hammack Scott | Modulators of gpr68 and uses thereof for treating and preventing diseases |
| WO2019155474A1 (en) | 2018-02-12 | 2019-08-15 | Hadasit Medical Research Services & Development Ltd. | Modulation of slamf6 splice variants for cancer therapy |
| WO2019158512A1 (en) | 2018-02-13 | 2019-08-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the prognosis and the treatment of glioblastoma |
| US11512127B2 (en) | 2018-02-14 | 2022-11-29 | Viela Bio, Inc. | Antibodies to Feline McDonough Sarcoma (FMS)-like tyrosine kinase 3 receptor ligand (FLT3L) and uses thereof for treating autoimmune and inflammatory diseases |
| GB201802486D0 (en) | 2018-02-15 | 2018-04-04 | Ucb Biopharma Sprl | Methods |
| EP3759141A1 (en) | 2018-02-26 | 2021-01-06 | F. Hoffmann-La Roche AG | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
| EP3759493A1 (en) | 2018-02-28 | 2021-01-06 | The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center | Methods of diagnosing and treating bladder cancer |
| EP3762015A4 (en) | 2018-03-05 | 2022-04-27 | Janssen Biotech, Inc. | METHODS OF TREATING CROHN'S DISEASE WITH SPECIFIC ANTI-IL23 ANTIBODY |
| CA3093772C (en) | 2018-03-12 | 2024-04-16 | Zoetis Services Llc | Anti-ngf antibodies and methods thereof |
| CA3092345A1 (en) | 2018-03-13 | 2019-09-19 | The Regents Of The University Of California | Inhibitors of integrin alpha 2 beta 1 and methods of use |
| AU2019235033A1 (en) | 2018-03-14 | 2020-07-30 | Beijing Xuanyi Pharmasciences Co., Ltd. | Anti-claudin 18.2 antibodies |
| US11203646B2 (en) | 2018-03-14 | 2021-12-21 | Novimmune Sa | Anti-CD3 epsilon antibodies and methods of use thereof |
| US20210070819A1 (en) | 2018-03-16 | 2021-03-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antigenic peptides deriving from secretogranin v and uses thereof for the diagnosis and treatment of type 1 diabetes |
| US20210023209A1 (en) | 2018-03-16 | 2021-01-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antigenic peptides deriving from pcsk2 and uses thereof for the diagnosis and treatment of type 1 diabetes |
| EP3765053A2 (en) | 2018-03-16 | 2021-01-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antigenic peptides deriving from urocortin 3 and uses thereof for the diagnosis and treatment of type 1 diabetes |
| EP3768314A4 (en) | 2018-03-21 | 2022-01-05 | ALX Oncology Inc. | ANTIBODIES AGAINST ALPHA SIGNAL REGULATING PROTEIN AND METHODS OF USE |
| JP7351845B2 (ja) | 2018-03-23 | 2023-09-27 | ブリストル－マイヤーズ スクイブ カンパニー | Ｍｉｃａおよび／またはｍｉｃｂに対する抗体ならびにそれらの使用 |
| US11993658B2 (en) | 2018-03-26 | 2024-05-28 | Sutro Biopharma, Inc. | Anti-BCMA antibodies and treatment methods |
| US20210047696A1 (en) | 2018-03-28 | 2021-02-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cancer |
| KR20200136464A (ko) | 2018-03-29 | 2020-12-07 | 브리스톨-마이어스 스큅 컴퍼니 | 단량체성 모노클로날 항체를 정제하는 방법 |
| CN111886254B (zh) | 2018-03-30 | 2023-12-08 | 南京传奇生物科技有限公司 | 针对lag-3的单结构域抗体及其用途 |
| WO2019193375A1 (en) | 2018-04-04 | 2019-10-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of fzd7 inhibitors for the treatment of retinal neovascularization |
| EP3774916A2 (en) | 2018-04-06 | 2021-02-17 | Biolegend, Inc. | Anti-tetraspanin 33 agents and compositions and methods for making and using the same |
| WO2019197683A1 (en) | 2018-04-13 | 2019-10-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting outcome and treatment of patients suffering from prostate cancer or breast cancer |
| FR3080376B1 (fr) | 2018-04-20 | 2022-12-09 | Lab Francais Du Fractionnement | Autoanticorps hautement sialyles et leurs utilisations |
| CA3098374A1 (en) | 2018-04-25 | 2019-10-31 | Prometheus Biosciences, Inc. | Optimized anti-tl1a antibodies |
| WO2019207030A1 (en) | 2018-04-26 | 2019-10-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting a response with an immune checkpoint inhibitor in a patient suffering from a lung cancer |
| EP3788071A1 (en) | 2018-05-02 | 2021-03-10 | The United States Of America, As Represented By The Secretary, Department of Health and Human Services | Antibodies and methods for the diagnosis, prevention, and treatment of epstein barr virus infection |
| WO2019211369A1 (en) | 2018-05-03 | 2019-11-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cancer |
| WO2019211370A1 (en) | 2018-05-03 | 2019-11-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cancer |
| CA3099079A1 (en) | 2018-05-04 | 2019-11-07 | Merck Patent Gmbh | Combined inhibition of pd-1/pd-l1, tgf.beta. and dna-pk for the treatment of cancer |
| KR20210005617A (ko) | 2018-05-07 | 2021-01-14 | 젠맵 에이/에스 | 항-pd-1 항체와 항-조직 인자 항체-약물 접합체의 조합을 사용하여 암을 치료하는 방법 |
| CN112739716A (zh) | 2018-05-07 | 2021-04-30 | 展马博联合股份有限公司 | 使用抗pd-1抗体与抗组织因子抗体-药物偶联物的组合治疗癌症的方法 |
| MA52590A (fr) | 2018-05-11 | 2021-03-17 | Janssen Biotech Inc | Méthodes de traitement de la dépression à l'aide d'anticorps il-23 |
| CN114685665A (zh) | 2018-05-11 | 2022-07-01 | 同润澳门一人有限公司 | 抗ox40的全人抗体及其制备方法和用途 |
| CA3100828A1 (en) | 2018-05-23 | 2019-11-28 | Pfizer Inc. | Antibodies specific for cd3 and uses thereof |
| KR20230146098A (ko) | 2018-05-23 | 2023-10-18 | 화이자 인코포레이티드 | GUCY2c에 특이적인 항체 및 이의 용도 |
| MX2020012587A (es) | 2018-05-24 | 2021-04-28 | Janssen Biotech Inc | Anticuerpos anti-cd3 y usos de estos. |
| WO2019225787A1 (ko) | 2018-05-24 | 2019-11-28 | 에이비엘바이오 주식회사 | 항-b7-h3 항체 및 그 용도 |
| MA52777A (fr) | 2018-05-24 | 2021-04-14 | Janssen Biotech Inc | Agents de liaison psma et utilisations correspondantes |
| KR20210011999A (ko) | 2018-05-24 | 2021-02-02 | 얀센 바이오테크 인코포레이티드 | 단일특이성 및 다중특이성 항-tmeff2 항체 및 이의 용도 |
| BR112020023844A2 (pt) | 2018-05-25 | 2021-04-13 | Alector Llc | Anticorpos, métodos de tratamento do câncer e de produção de um anticorpo, ácido nucleico, vetor, células hospedeiras e composição farmacêutica |
| AR126019A1 (es) | 2018-05-30 | 2023-09-06 | Novartis Ag | Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación |
| EP3803332A1 (en) | 2018-06-01 | 2021-04-14 | NanoView Biosciences, Inc. | Compositions, systems, and methods for enhanced label-free and fluorescence - based detection of nanoparticles |
| WO2019234099A1 (en) | 2018-06-06 | 2019-12-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing, predicting the outcome and treating a patient suffering from heart failure with preserved ejection fraction |
| MA52764A (fr) | 2018-06-08 | 2021-04-28 | Alector Llc | Anticorps anti-siglec-7 et leurs méthodes d'utilisation |
| WO2019234221A1 (en) | 2018-06-08 | 2019-12-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for stratification and treatment of a patient suffering from chronic lymphocytic leukemia |
| EP3806904A4 (en) | 2018-06-18 | 2022-04-27 | Eureka Therapeutics, Inc. | PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) TARGETED CONSTRUCTS AND USES THEREOF |
| CA3102743A1 (en) | 2018-06-18 | 2019-12-26 | UCB Biopharma SRL | Gremlin-1 antagonist for the prevention and treatment of cancer |
| MA52968A (fr) | 2018-06-23 | 2021-04-28 | Hoffmann La Roche | Méthodes de traitement du cancer du poumon à l'aide d'un antagoniste de liaison à l'axe pd-1, d'un agent de platine et d'un inhibiteur de la topoisomérase ii |
| WO2020006176A1 (en) | 2018-06-27 | 2020-01-02 | Obi Pharma, Inc. | Glycosynthase variants for glycoprotein engineering and methods of use |
| US20210277113A1 (en) | 2018-06-29 | 2021-09-09 | Alector Llc | Anti-SIRP-Beta1 Antibodies and Methods of Use Thereof |
| US20210395329A1 (en) | 2018-06-29 | 2021-12-23 | City Of Hope | Cd6 targeted chimeric antigen receptors for treatent of certain autoimmune disorders |
| CN112638403A (zh) | 2018-07-03 | 2021-04-09 | 康泰伦特药物解决方案有限责任公司 | 包括饰胶蛋白聚糖的多功能蛋白质分子及其用途 |
| WO2020007898A1 (en) | 2018-07-04 | 2020-01-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating brain injury or neurodegenerative disease |
| TWI819024B (zh) | 2018-07-09 | 2023-10-21 | 美商戊瑞治療有限公司 | 結合至ｉｌｔ４的抗體 |
| SG11202012835RA (en) | 2018-07-10 | 2021-01-28 | Regeneron Pharma | Modifying binding molecules to minimize pre-existing interactions |
| GB201811368D0 (en) | 2018-07-11 | 2018-08-29 | Ucb Biopharma Sprl | Antibody |
| WO2020012435A1 (en) | 2018-07-13 | 2020-01-16 | Lausanne University Hospital | Hiv binding agents |
| US20210275589A1 (en) | 2018-07-13 | 2021-09-09 | Nanjing Legend Biotech Co. Ltd. | Co-receptor systems for treating infectious diseases |
| AU2019246837B2 (en) | 2018-07-13 | 2024-03-21 | Alector Llc | Anti-Sortilin antibodies and methods of use thereof |
| BR112021000673A2 (pt) | 2018-07-18 | 2021-04-20 | Genentech, Inc. | métodos para tratar um indivíduo com câncer de pulmão, kits, anticorpo anti-pd-l1 e composições |
| EP3824295A4 (en) | 2018-07-18 | 2022-04-27 | Janssen Biotech, Inc. | PREDICTORS OF PROLONGED RESPONSE AFTER TREATMENT WITH AN ANTI-IL23 SPECIFIC ANTIBODY |
| JP2021531027A (ja) | 2018-07-27 | 2021-11-18 | アレクトル エルエルシー | 抗Ｓｉｇｌｅｃ−５抗体及びその使用方法 |
| AU2019313444A1 (en) | 2018-07-30 | 2021-02-18 | Amgen Inc. | Prolonged administration of a bispecific antibody construct binding to CD33 and CD3 |
| TW202023581A (zh) | 2018-08-02 | 2020-07-01 | 日商腫瘤療法 科學股份有限公司 | 來自cdca1的胜肽及含有此的疫苗 |
| CN112512581A (zh) | 2018-08-03 | 2021-03-16 | 安进研发（慕尼黑）股份有限公司 | 针对cldn18.2和cd3的抗体构建体 |
| BR112021002130A2 (pt) | 2018-08-08 | 2021-05-04 | Genentech, Inc. | formulação líquida, artigo de fabricação ou kit e método para reduzir a oxidação de um polipeptídeo |
| IL261156A (en) | 2018-08-14 | 2020-02-27 | Fass Deborah | Chimeric quiescin sulfhydryl oxidase (qsox1) antibodies and uses of same |
| CN112867503A (zh) | 2018-08-24 | 2021-05-28 | 希望之城 | 掩蔽的细胞因子缀合物 |
| AU2019327155A1 (en) | 2018-08-27 | 2021-03-18 | Affimed Gmbh | Cryopreserved NK cells preloaded with an antibody construct |
| CR20210155A (es) | 2018-08-31 | 2021-05-10 | Alector Llc | Anticuerpos anti-cd33 y métodos para usarlos |
| EP3850008A1 (en) | 2018-09-10 | 2021-07-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of an inhibitor of ntsr1 activation or expression for preventing weight loss, muscle loss, and protein blood level decrease in subjects in need thereof |
| US20220105176A1 (en) | 2018-09-12 | 2022-04-07 | Acm Biolabs Pte Ltd | Polymersomes comprising a covalently bound antigen as well as methods of making and uses thereof |
| US10899826B1 (en) | 2018-09-13 | 2021-01-26 | Teva Pharmaceuticals International Gmbh | Pharmaceutical compositions for an anti-CGRP antagonist antibody |
| WO2020053661A1 (en) | 2018-09-13 | 2020-03-19 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Methods of purifying antibodies from the milk of transgenic non-human mammals comprising the use of chitosan |
| JP2022500454A (ja) | 2018-09-17 | 2022-01-04 | ストロ バイオファーマ インコーポレーテッド | 抗葉酸受容体抗体コンジュゲートによる併用療法 |
| KR20210089143A (ko) | 2018-09-18 | 2021-07-15 | 메리맥 파마슈티컬즈, 인크. | 항-tnfr2 항체 및 그의 용도 |
| JP2022511337A (ja) | 2018-09-19 | 2022-01-31 | インサーム （インスティテュート ナショナル デ ラ サンテ エ デ ラ ルシェルシェ メディカル） | 免疫チェックポイント治療に抵抗性のある癌の治療のための方法および医薬組成物 |
| WO2020061381A1 (en) | 2018-09-19 | 2020-03-26 | La Jolla Institute For Immunology | Ptprs and proteoglycans in rheumatoid arthritis |
| WO2020061060A1 (en) | 2018-09-19 | 2020-03-26 | Genentech, Inc. | Therapeutic and diagnostic methods for bladder cancer |
| JP2022502488A (ja) | 2018-09-21 | 2022-01-11 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 粘液を透過するのを制限するための合成結合剤 |
| EP4249917A3 (en) | 2018-09-21 | 2023-11-08 | F. Hoffmann-La Roche AG | Diagnostic methods for triple-negative breast cancer |
| CA3113837C (en) | 2018-09-24 | 2022-07-12 | Janssen Biotech, Inc. | Safe and effective method of treating ulcerative colitis with anti-il12/il23 antibody |
| WO2020064702A1 (en) | 2018-09-25 | 2020-04-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of antagonists of th17 cytokines for the treatment of bronchial remodeling in patients suffering from allergic asthma |
| EP3856343A1 (en) | 2018-09-25 | 2021-08-04 | Biolegend, Inc. | Anti-tlr9 agents and compositions and methods for making and using the same |
| CN113286614A (zh) | 2018-09-26 | 2021-08-20 | 默克专利股份有限公司 | 用于治疗癌症的pd-1拮抗剂、atr抑制剂和铂化物质的组合 |
| JP2022502052A (ja) | 2018-09-27 | 2022-01-11 | ティゾナ セラピューティクス | 抗ｈｌａ−ｇ抗体、抗ｈｌａ−ｇ抗体を含む組成物、および抗ｈｌａ−ｇ抗体を使用する方法 |
| WO2020070062A1 (en) | 2018-10-01 | 2020-04-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of tim-3 inhibitors for the treatment of exacerbations in patients suffering from severe asthma |
| JP2022512626A (ja) | 2018-10-04 | 2022-02-07 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 粘膜炎症性疾患の処置のための方法及び医薬組成物 |
| WO2020074937A1 (en) | 2018-10-09 | 2020-04-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of alpha-v-integrin (cd51) inhibitors for the treatment of cardiac fibrosis |
| CN113645995A (zh) | 2018-10-11 | 2021-11-12 | 辉瑞公司 | Tfpi拮抗剂的剂量方案 |
| CN112789058A (zh) | 2018-10-11 | 2021-05-11 | 安进公司 | 双特异性抗体构建体的下游加工 |
| JP2022505041A (ja) | 2018-10-15 | 2022-01-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｄｎａアルキル化剤及びａｔｒ阻害剤を使用する併用療法 |
| UY38407A (es) | 2018-10-15 | 2020-05-29 | Novartis Ag | Anticuerpos estabilizadores de trem2 |
| IL282317B2 (en) | 2018-10-17 | 2024-04-01 | Biolinerx Ltd | Treatment of metastatic adenocarcinoma of the pancreas |
| KR20210079311A (ko) | 2018-10-18 | 2021-06-29 | 제넨테크, 인크. | 육종성 신장암에 대한 진단과 치료 방법 |
| WO2020079164A1 (en) | 2018-10-18 | 2020-04-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combination of a big-h3 antagonist and an immune checkpoint inhibitor for the treatment of solid tumor |
| GB201817309D0 (en) | 2018-10-24 | 2018-12-05 | Ucb Biopharma Sprl | Antibodies |
| GB201817311D0 (en) | 2018-10-24 | 2018-12-05 | Ucb Biopharma Sprl | Antibodies |
| EA202190734A1 (ru) | 2018-10-30 | 2021-10-15 | Генмаб А/С | Способы лечения рака с помощью комбинации антитела против vegf и конъюгата антитело против тканевого фактора-лекарственное средство |
| KR20210108363A (ko) | 2018-11-02 | 2021-09-02 | 오클라호마 메디컬 리써치 화운데이션 | Eltd1에 대한 단일클론성 항체 및 이의 용도 |
| US20200140533A1 (en) | 2018-11-02 | 2020-05-07 | Annexon, Inc. | Compositions and methods for treating brain injury |
| JP2022506156A (ja) | 2018-11-05 | 2022-01-17 | ジェネンテック， インコーポレイテッド | 原核宿主細胞における２鎖タンパク質の産生方法 |
| BR112021009111A2 (pt) | 2018-11-16 | 2021-08-24 | Bristol-Myers Squibb Company | Anticorpos anti-nkg2a e usos dos mesmos |
| EP3880837A1 (en) | 2018-11-16 | 2021-09-22 | F. Hoffmann-La Roche AG | Streptavidin-coated solid phases with a member of a binding pair |
| AU2019380320A1 (en) | 2018-11-16 | 2021-06-03 | Eureka Therapeutics, Inc. | Antibodies to Mucin-16 and methods of use thereof |
| EP3883961A1 (en) | 2018-11-20 | 2021-09-29 | Takeda Vaccines, Inc. | Novel anti-zika virus antibodies and uses thereof |
| MX2021005905A (es) | 2018-11-20 | 2021-06-23 | Janssen Biotech Inc | Metodo seguro y eficaz para tratar la psoriasis con el anticuerpo especifico anti-il-23. |
| EP3660048A1 (en) | 2018-11-29 | 2020-06-03 | Assistance Publique - Hôpitaux De Paris | Treatment of acute gvhd using donor-specific anti-hla antibodies |
| MX2021006544A (es) | 2018-12-04 | 2021-07-07 | Sumitomo Pharma Oncology Inc | Inhibidores de cinasa dependiente de ciclina 9 (cdk9) y polimorfos de los mismos para uso como agentes para el tratamiento de cancer. |
| WO2020123691A2 (en) | 2018-12-12 | 2020-06-18 | Kite Pharma, Inc | Chimeric antigen and t cell receptors and methods of use |
| US20200197517A1 (en) | 2018-12-18 | 2020-06-25 | Janssen Biotech, Inc. | Safe and Effective Method of Treating Lupus with Anti-IL12/IL23 Antibody |
| AR117453A1 (es) | 2018-12-20 | 2021-08-04 | Genentech Inc | Fc de anticuerpos modificados y métodos para utilizarlas |
| CN113474048A (zh) | 2018-12-21 | 2021-10-01 | Aim免疫科技有限公司 | 用于癌症治疗的组合物和方法 |
| KR20210111792A (ko) | 2018-12-28 | 2021-09-13 | 스팍스 테라퓨틱스 인크. | 암 및 다른 질환을 치료하기 위한 클라우딘 18.2에 특이적인 결합 분자, 이의 조성물 및 방법 |
| BR112021013157A8 (pt) | 2019-01-03 | 2022-12-06 | Inst Nat Sante Rech Med | Usos de um inibidor de nrp-1, uso de uma combinação, uso de um anticorpo multiespecífico, método ex vivo para predizer, uso de um inibidor, anticorpo multiespecífico, população de células modificadas, método ex vivo de produção e uso de uma população de células t |
| TW202043256A (zh) | 2019-01-10 | 2020-12-01 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
| MA54752A (fr) | 2019-01-14 | 2021-11-24 | Univ Virginia Patent Foundation | Utilisation d'inhibiteurs d'intégrine pour le traitement ou la prévention d'un trouble immunitaire neurologique et/ou d'une lésion du système nerveux |
| CA3124837A1 (en) | 2019-01-14 | 2020-07-23 | Genentech, Inc. | Methods of treating cancer with a pd-1 axis binding antagonist and an rna vaccine |
| CA3126654A1 (en) | 2019-01-15 | 2020-07-23 | Janssen Biotech, Inc. | Anti-tnf antibody compositions and methods for the treatment of juvenile idiopathic arthritis |
| GB201900732D0 (en) | 2019-01-18 | 2019-03-06 | Ucb Biopharma Sprl | Antibodies |
| JP7285936B2 (ja) | 2019-01-22 | 2023-06-02 | ブリストル－マイヤーズ スクイブ カンパニー | Ｉｌ－７ｒアルファサブユニットに対する抗体及びその使用 |
| CA3124515A1 (en) | 2019-01-23 | 2020-07-30 | Genentech, Inc. | Methods of producing multimeric proteins in eukaryotic host cells |
| WO2020152544A1 (en) | 2019-01-23 | 2020-07-30 | Janssen Biotech, Inc. | Anti-tnf antibody compositions for use in methods for the treatment of psoriatic arthritis |
| CN113348178A (zh) | 2019-01-28 | 2021-09-03 | 枫叶生物技术有限公司 | 用于治疗肺、肾或肝的纤维化疾病的psmp拮抗剂 |
| JP2022519649A (ja) | 2019-02-08 | 2022-03-24 | ジェネンテック， インコーポレイテッド | がんの診断および治療方法 |
| IL264768A (en) | 2019-02-10 | 2020-08-31 | Sagi Irit | ANTI-MATRIX METALLOPROTEINASE 7 (MMP-7) inhibitory antibody and its use |
| CN114072423A (zh) | 2019-02-21 | 2022-02-18 | 翠舒拉治疗股份有限公司 | 涉及抗cd39抗体和抗pd-1或抗pd-l1抗体的组合疗法 |
| MX2021010313A (es) | 2019-02-27 | 2021-09-23 | Genentech Inc | Dosificacion para el tratamiento con anticuerpos anti-tigit y anti-cd20 o anti-cd38. |
| WO2020178193A1 (en) | 2019-03-01 | 2020-09-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method of treatment of sarcoidosis |
| US20220281990A1 (en) | 2019-03-01 | 2022-09-08 | Merrimack Pharmaceuticals, Inc. | Anti-tnfr2 antibodies and uses thereof |
| EP4112125A1 (en) | 2019-03-12 | 2023-01-04 | President and Fellows of Harvard College | Methods and compositions for treating cancer |
| EA202192508A1 (ru) | 2019-03-14 | 2022-03-29 | Янссен Байотек, Инк. | Способы получения композиций антитела к фно |
| MA55283A (fr) | 2019-03-14 | 2022-01-19 | Janssen Biotech Inc | Procédés de production de compositions d'anticorps anti-tnf |
| JP2022525145A (ja) | 2019-03-14 | 2022-05-11 | ヤンセン バイオテツク，インコーポレーテツド | 抗ｉｌ１２／ｉｌ２３抗体組成物を生成するための製造方法 |
| EP3938390A1 (en) | 2019-03-14 | 2022-01-19 | Janssen Biotech, Inc. | Manufacturing methods for producing anti-tnf antibody compositions |
| CN113853385A (zh) | 2019-03-18 | 2021-12-28 | 詹森生物科技公司 | 用抗il12/il23抗体治疗儿科受试者的银屑病的方法 |
| US11793802B2 (en) | 2019-03-20 | 2023-10-24 | Sumitomo Pharma Oncology, Inc. | Treatment of acute myeloid leukemia (AML) with venetoclax failure |
| EP3942026A1 (en) | 2019-03-22 | 2022-01-26 | Université de Paris | New inhibitors of lrrk2/pp1 interaction |
| SG11202109545VA (en) | 2019-03-26 | 2021-10-28 | Aslan Pharmaceuticals Pte Ltd | Treatment employing anti-il-13r antibody or binding fragment thereof |
| WO2020194317A1 (en) | 2019-03-28 | 2020-10-01 | Yeda Research And Development Co. Ltd. | Method of treating lipid-related disorders |
| US20220042954A1 (en) | 2019-03-29 | 2022-02-10 | Bristol-Myers Squibb Company | Methods of measuring hydrophobicity of chromatographic resins |
| EP3947737A2 (en) | 2019-04-02 | 2022-02-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
| WO2020201442A1 (en) | 2019-04-03 | 2020-10-08 | Orega Biotech | Combination therapies based on pd1 and il-17b inhibitors |
| US11180561B2 (en) | 2019-04-09 | 2021-11-23 | Abcuro, Inc. | Killer cell lectin-like receptor subfamily G member 1 (KLRG1) depleting antibodies |
| JP2022528804A (ja) | 2019-04-18 | 2022-06-15 | ジェネンテック， インコーポレイテッド | 抗体力価試験 |
| US11591395B2 (en) | 2019-04-19 | 2023-02-28 | Janssen Biotech, Inc. | Methods of treating prostate cancer with an anti-PSMA/CD3 antibody |
| JP2022530482A (ja) | 2019-05-02 | 2022-06-29 | レゴケム バイオサイエンシズ， インク． | トリス構造を有するリンカーを含むリガンド―薬物複合体 |
| AU2020270376A1 (en) | 2019-05-03 | 2021-10-07 | Genentech, Inc. | Methods of treating cancer with an anti-PD-L1 antibody |
| WO2020227105A1 (en) | 2019-05-03 | 2020-11-12 | Sutro Biopharma, Inc. | Anti-bcma antibody conjugates |
| AU2020270407A1 (en) | 2019-05-03 | 2021-12-02 | Celgene Corporation | Anti-BCMA antibody conjugate, compositions comprising the same, and methods of making and using the same |
| US20220259561A1 (en) | 2019-05-14 | 2022-08-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Regulatory t cells targeted by lymphotoxin alpha blocking agent and uses thereof |
| WO2020232262A1 (en) | 2019-05-16 | 2020-11-19 | Procisedx Inc. | Assay detection methods for vcam-1 and calprotectin |
| EP3821250B1 (en) | 2019-05-16 | 2022-05-04 | ProciseDx Inc. | An assay method for the detection of vcam-1 and alpha-2-macroglobulin in blood |
| US20200369759A1 (en) | 2019-05-23 | 2020-11-26 | Fibrogen, Inc. | Methods of treatment of muscular dystrophies |
| BR112021023295A2 (pt) | 2019-05-23 | 2022-02-08 | Janssen Biotech Inc | Método de tratamento de doença inflamatória intestinal com uma terapia de combinação de anticorpos para il-23 e tnf-alfa |
| WO2020236528A1 (en) | 2019-05-23 | 2020-11-26 | Procisedx Inc. | Assay methods for the detection of human serum albumin, vitamin d, c-reactive protein, and anti-transglutaminase autoantibody |
| WO2020243477A2 (en) | 2019-05-30 | 2020-12-03 | Amgen Inc. | Engineering the hinge region to drive antibody dimerization |
| CA3142580A1 (en) | 2019-06-03 | 2020-12-10 | Janssen Biotech, Inc. | Anti-tnf antibodies, compositions, and methods for the treatment of active ankylosing spondylitis |
| BR112021024425A2 (pt) | 2019-06-03 | 2022-01-18 | Janssen Biotech Inc | Composições de anticorpo anti-tnf e métodos para o tratamento de artrite psoriática |
| AR119264A1 (es) | 2019-06-05 | 2021-12-09 | Genentech Inc | Método para reutilización de cromatografía |
| JP2022535125A (ja) | 2019-06-06 | 2022-08-04 | プロサイセデクス インコーポレイティド | 血中ヘモグロビンＡ１Ｃ（ＨｂＡ１ｃ）の検出 |
| CN114269749A (zh) | 2019-06-10 | 2022-04-01 | 苏特罗生物制药公司 | 5H-吡咯并[3,2-d]嘧啶-2,4-二氨基化合物及其抗体偶联物 |
| TW202112817A (zh) | 2019-06-11 | 2021-04-01 | 美商阿列克特有限責任公司 | 抗揀選蛋白抗體之使用方法 |
| WO2020252257A1 (en) | 2019-06-12 | 2020-12-17 | President And Fellows Of Harvard College | Methods and compositions for modulation of an interspecies gut bacterial pathway for levodopa metabolism |
| JP2022536358A (ja) | 2019-06-12 | 2022-08-15 | ノバルティス アーゲー | ナトリウム利尿ペプチド受容体１抗体及び使用方法 |
| CA3137494A1 (en) | 2019-06-13 | 2020-12-17 | Amgen Inc. | Automated biomass-based perfusion control in the manufacturing of biologics |
| JP2022536800A (ja) | 2019-06-17 | 2022-08-18 | ストロ バイオファーマ インコーポレーテッド | Ｔｏｌｌ様受容体（ｔｌｒ）７／８アゴニストとしての１－（４－（アミノメチル）ベンジル）－２－ブチル－２ｈ－ピラゾロ［３，４－ｃ］キノリン－４－アミン誘導体および関連化合物、ならびにがん療法および診断に使用するためのその抗体薬物コンジュゲート |
| WO2020263450A1 (en) | 2019-06-25 | 2020-12-30 | Procisedx Inc. | Detection of anti-tnf alpha drug biologics and anti-drug antibodies |
| EP3989937A1 (en) | 2019-06-28 | 2022-05-04 | Genentech, Inc. | Composition and methods for stabilizing liquid protein formulations |
| WO2020264384A1 (en) | 2019-06-28 | 2020-12-30 | Amgen Inc. | Anti-cgrp receptor/anti-pac1 receptor bispecific antigen binding proteins |
| JP2022538886A (ja) | 2019-07-01 | 2022-09-06 | トリアニ・インコーポレイテッド | トランスジェニック哺乳動物およびその使用法 |
| JP2022538885A (ja) | 2019-07-01 | 2022-09-06 | トリアニ・インコーポレイテッド | トランスジェニック哺乳動物およびその使用法 |
| US20220267416A1 (en) | 2019-07-15 | 2022-08-25 | Lausanne University Hospital | Hiv binding agents |
| IL268111A (en) | 2019-07-16 | 2021-01-31 | Fainzilber Michael | Methods of treating pain |
| CA3147103A1 (en) | 2019-07-19 | 2021-01-28 | Oncoresponse, Inc. | Immunomodulatory antibodies and methods of use thereof |
| WO2021014389A1 (en) | 2019-07-24 | 2021-01-28 | H. Lundbeck A/S | Anti-mglur5 antibodies and uses thereof |
| CN112300279A (zh) | 2019-07-26 | 2021-02-02 | 上海复宏汉霖生物技术股份有限公司 | 针对抗cd73抗体和变体的方法和组合物 |
| JP2022542890A (ja) | 2019-07-26 | 2022-10-07 | アムジエン・インコーポレーテツド | 抗ｉｌ１３抗原結合タンパク質 |
| CA3147735A1 (en) | 2019-07-26 | 2021-02-04 | Janssen Biotech, Inc. | Proteins comprising kallikrein related peptidase 2 antigen binding domains and their uses |
| CA3147575A1 (en) | 2019-07-29 | 2021-02-04 | Yeda Research And Development Co. Ltd. | Methods of treating and diagnosing lung cancer |
| WO2021022083A2 (en) | 2019-07-31 | 2021-02-04 | Alector Llc | Anti-ms4a4a antibodies and methods of use thereof |
| EP4007584A1 (en) | 2019-08-02 | 2022-06-08 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Neutralizing granzyme b for providing cardioprotection in a subject who experienced a myocardial infarction |
| EP4013788A1 (en) | 2019-08-12 | 2022-06-22 | Purinomia Biotech, Inc. | Methods and compositions for promoting and potentiating t-cell mediated immune responses through adcc targeting of cd39 expressing cells |
| EP4013783A1 (en) | 2019-08-15 | 2022-06-22 | Janssen Biotech, Inc. | Materials and methods for improved single chain variable fragments |
| WO2021028752A1 (en) | 2019-08-15 | 2021-02-18 | Janssen Biotech, Inc. | Anti-tfn antibodies for treating type i diabetes |
| US20240140988A1 (en) | 2019-08-22 | 2024-05-02 | Ariel Scientific Innovations Ltd. | Scaled-up methods for purifying antibodies |
| EP4025608A1 (en) | 2019-09-04 | 2022-07-13 | F. Hoffmann-La Roche AG | Cd8 binding agents and uses thereof |
| AU2020345787A1 (en) | 2019-09-10 | 2022-03-24 | Amgen Inc. | Purification method for bispecific antigen-binding polypeptides with enhanced protein L capture dynamic binding capacity |
| WO2021048852A1 (en) | 2019-09-11 | 2021-03-18 | Yeda Research And Development Co. Ltd. | Methods of treating breast cancer |
| WO2021050645A1 (en) | 2019-09-12 | 2021-03-18 | Genentech, Inc. | Compositions and methods of treating lupus nephritis |
| WO2021053559A1 (en) | 2019-09-18 | 2021-03-25 | Novartis Ag | Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies |
| TW202124446A (zh) | 2019-09-18 | 2021-07-01 | 瑞士商諾華公司 | 與ｅｎｔｐｄ２抗體之組合療法 |
| WO2021062085A1 (en) | 2019-09-27 | 2021-04-01 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
| EP4034151A1 (en) | 2019-09-27 | 2022-08-03 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Use of müllerian inhibiting substance inhibitors for treating cancer |
| US20220363776A1 (en) | 2019-10-04 | 2022-11-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the treatment of ovarian cancer, breast cancer or pancreatic cancer |
| CA3153932A1 (en) | 2019-10-07 | 2021-04-15 | Jonathan Kipnis | Modulating lymphatic vessels in neurological disease |
| EP3804754A1 (en) | 2019-10-09 | 2021-04-14 | OSE Immunotherapeutics | Cmklr1 agonists having a resolvin e1-like capability and their therapeutic applications |
| TW202128160A (zh) | 2019-10-18 | 2021-08-01 | 美國加利福尼亞大學董事會 | 用於治療病原性血管病症之方法及組合物 |
| EP3812008A1 (en) | 2019-10-23 | 2021-04-28 | Gamamabs Pharma | Amh-competitive antagonist antibody |
| BR112022007720A2 (pt) | 2019-10-24 | 2022-08-23 | Prometheus Biosciences Inc | Anticorpos humanizados para ligante 1a tnf-like (tl1a) e seus usos |
| US20230044248A1 (en) | 2019-11-01 | 2023-02-09 | Ares Trading S.A. | COMBINED INHIBITION OF PD-1, TGFBeta AND ATM TOGETHER WITH RADIOTHERAPY FOR THE TREATMENT OF CANCER |
| EP4054647A1 (en) | 2019-11-04 | 2022-09-14 | Seagen Inc. | Anti-cd30 antibody-drug conjugates and their use for the treatment of hiv infection |
| US20230340122A1 (en) | 2019-11-05 | 2023-10-26 | Glaxosmithkline Intellectual Property (No. 4) Ltd. | Combined inhibition of pd-1, tgfb and tigit for the treatment of cancer |
| WO2021092171A1 (en) | 2019-11-06 | 2021-05-14 | Genentech, Inc. | Diagnostic and therapeutic methods for treatment of hematologic cancers |
| AU2020380732A1 (en) | 2019-11-07 | 2022-06-02 | Genmab A/S | Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-tissue factor antibody-drug conjugate |
| TW202131954A (zh) | 2019-11-07 | 2021-09-01 | 丹麥商珍美寶股份有限公司 | 利用鉑類劑與抗組織因子抗體－藥物共軛體之組合來治療癌症之方法 |
| MX2022005566A (es) | 2019-11-08 | 2022-07-19 | Amgen Inc | Genomanipulación de mutaciones de par de carga para el emparejamiento de moléculas hetero-lgg. |
| AU2020381536A1 (en) | 2019-11-13 | 2022-04-21 | Amgen Inc. | Method for reduced aggregate formation in downstream processing of bispecific antigen-binding molecules |
| PE20221182A1 (es) | 2019-11-18 | 2022-08-05 | Janssen Biotech Inc | Vacunas basadas en calr y jak2 mutantes y sus usos |
| AU2020386005A1 (en) | 2019-11-19 | 2022-05-26 | Amgen Inc. | Novel multispecific antibody format |
| GB201917480D0 (en) | 2019-11-29 | 2020-01-15 | Univ Oxford Innovation Ltd | Antibodies |
| AU2020397888A1 (en) | 2019-12-05 | 2022-06-09 | Alector Llc | Methods of use of anti-TREM2 antibodies |
| EP4073810A1 (en) | 2019-12-09 | 2022-10-19 | Sanofi Biotechnology | Methods for treating digitally-identified il-4/il-13 related disorders |
| US20230039268A1 (en) | 2019-12-09 | 2023-02-09 | Genentech, Inc. | Anti-pd-l1 antibody formulations |
| EP3992974A1 (en) | 2020-11-02 | 2022-05-04 | Sanofi Biotechnology | Methods for treating digitally-identified il-4/il-13 related disorders |
| CA3161206A1 (en) | 2019-12-12 | 2021-06-17 | Alector Llc | Methods of use of anti-cd33 antibodies |
| EP4072680A1 (en) | 2019-12-13 | 2022-10-19 | Alector LLC | Anti-mertk antibodies and methods of use thereof |
| GB201919061D0 (en) | 2019-12-20 | 2020-02-05 | Ucb Biopharma Sprl | Multi-specific antibody |
| GB201919058D0 (en) | 2019-12-20 | 2020-02-05 | Ucb Biopharma Sprl | Multi-specific antibodies |
| GB201919062D0 (en) | 2019-12-20 | 2020-02-05 | Ucb Biopharma Sprl | Antibody |
| MX2022007688A (es) | 2019-12-20 | 2022-07-19 | Amgen Inc | Constructos de anticuerpo multiespecificos agonistas de cd40 dirigidos a mesotelina para el tratamiento de tumores solidos. |
| AU2020414409A1 (en) | 2019-12-27 | 2022-06-16 | Affimed Gmbh | Method for the production of bispecific FcyRIIl x CD30 antibody construct |
| US20230076643A1 (en) | 2019-12-30 | 2023-03-09 | City Of Hope | Methods of making and using regulatory t cells and effector t cells having chimeric antigen receptors targeted to cd6, cd19, and/or an il-13r for treatment of autoimmune disorders and cancers |
| AU2021206618A1 (en) | 2020-01-06 | 2022-08-18 | Hifibio, Inc. | Anti-TNFR2 antibody and uses thereof |
| IL294466A (en) | 2020-01-07 | 2022-09-01 | Hifibio Hk Ltd | Anti-galectin-9 antibody and uses thereof |
| EP4090681A1 (en) | 2020-01-17 | 2022-11-23 | Biolegend, Inc. | Anti-tlr7 agents and compositions and methods for making and using the same |
| IL272194A (en) | 2020-01-22 | 2021-07-29 | Yeda Res & Dev | Multi-target antibodies for use in the treatment of diseases |
| WO2021150824A1 (en) | 2020-01-22 | 2021-07-29 | Amgen Research (Munich) Gmbh | Combinations of antibody constructs and inhibitors of cytokine release syndrome and uses thereof |
| WO2021151079A1 (en) | 2020-01-24 | 2021-07-29 | University Of Virginia Patent Foundation | Modulating lymphatic vessels in neurological disease |
| WO2021194481A1 (en) | 2020-03-24 | 2021-09-30 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
| WO2022050954A1 (en) | 2020-09-04 | 2022-03-10 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
| IL272390A (en) | 2020-01-30 | 2021-08-31 | Yeda Res & Dev | Cancer treatment methods |
| WO2021152587A1 (en) | 2020-01-30 | 2021-08-05 | Yeda Research And Development Co. Ltd. | Treating acute liver disease with tlr-mik inhibitors |
| IL272389A (en) | 2020-01-30 | 2021-08-31 | Yeda Res & Dev | Kits containing antibodies to PD-L1 and their uses in therapy |
| CN115397459A (zh) | 2020-01-31 | 2022-11-25 | 基因泰克公司 | 用pd-1轴结合拮抗剂和rna疫苗诱导新表位特异性t细胞的方法 |
| US20230070181A1 (en) | 2020-02-05 | 2023-03-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of treatment of cancer disease by targeting an epigenetic factor |
| TW202140012A (zh) | 2020-02-12 | 2021-11-01 | 比利時商健生藥品公司 | 用於治療尿路上皮癌的ｆｇｆｒ酪胺酸激酶抑制劑和抗ｐｄ１藥劑 |
| WO2021160266A1 (en) | 2020-02-13 | 2021-08-19 | UCB Biopharma SRL | Bispecific antibodies binding hvem and cd9 |
| US20230078678A1 (en) | 2020-02-13 | 2023-03-16 | Amgen Inc. | Formulations of human anti-tslp antibodies and methods of treating atopic dermatitis |
| CN113248611A (zh) | 2020-02-13 | 2021-08-13 | 湖南华康恒健生物技术有限公司 | 抗bcma抗体、其药物组合物及应用 |
| WO2021160268A1 (en) | 2020-02-13 | 2021-08-19 | UCB Biopharma SRL | Bispecific antibodies against cd9 |
| WO2021160265A1 (en) | 2020-02-13 | 2021-08-19 | UCB Biopharma SRL | Bispecific antibodies against cd9 and cd137 |
| WO2021160267A1 (en) | 2020-02-13 | 2021-08-19 | UCB Biopharma SRL | Bispecific antibodies against cd9 and cd7 |
| US20230073888A1 (en) | 2020-02-13 | 2023-03-09 | Amgen Inc. | Treatment of atopic dermatitis with anti-tslp antibody |
| EP4103610A1 (en) | 2020-02-13 | 2022-12-21 | UCB Biopharma SRL | Anti cd44-ctla4 bispecific antibodies |
| TW202144389A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在多發性骨髓瘤中表現之新抗原及其用途 |
| TW202144388A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在卵巢癌中表現之新抗原及其用途 |
| EP4106811A1 (en) | 2020-02-18 | 2022-12-28 | Amgen Inc. | Formulations of human anti-tslp antibodies and methods of using the same |
| EP4110814A1 (en) | 2020-02-24 | 2023-01-04 | Alector LLC | Methods of use of anti-trem2 antibodies |
| EP4110810A1 (en) | 2020-02-28 | 2023-01-04 | Orega Biotech | Combination therapies based on ctla4 and il-17b inhibitors |
| MX2022010327A (es) | 2020-03-03 | 2022-11-09 | Active Biotech Ab | Tasquinimod o una sal farmaceuticamente aceptable del mismo para el uso en una terapia combinada. |
| WO2021177980A1 (en) | 2020-03-06 | 2021-09-10 | Genentech, Inc. | Combination therapy for cancer comprising pd-1 axis binding antagonist and il6 antagonist |
| US20230146593A1 (en) | 2020-03-12 | 2023-05-11 | Amgen Inc. | Method for treatment and prophylaxis of crs in patients comprising a combination of bispecific antibodies binding to cds x cancer cell and tnf alpha or il-6 inhibitor |
| BR112022018176A2 (pt) | 2020-03-13 | 2022-12-06 | Janssen Biotech Inc | Materiais e métodos para ligação de siglec-3/cd33 |
| WO2021188851A1 (en) | 2020-03-19 | 2021-09-23 | Amgen Inc. | Antibodies against mucin 17 and uses thereof |
| CN115867577A (zh) | 2020-03-23 | 2023-03-28 | 基因泰克公司 | 用于预测covid-19肺炎中对il-6拮抗剂反应的生物标志物 |
| CN115916820A (zh) | 2020-03-23 | 2023-04-04 | 基因泰克公司 | 用il6拮抗剂治疗包括covid-19肺炎在内的肺炎的方法 |
| JP2023518812A (ja) | 2020-03-23 | 2023-05-08 | ジェネンテック， インコーポレイテッド | Ｃｏｖｉｄ１９肺炎を治療するための、トシリズマブとレムデシビルとの組み合わせ |
| CN113444171A (zh) | 2020-03-25 | 2021-09-28 | 兴盟生物医药(苏州)有限公司 | 金黄色葡萄球菌α-毒素特异性抗体及其应用 |
| EP4126937A1 (en) | 2020-03-31 | 2023-02-08 | Alector LLC | Anti-mertk antibodies and methods of use thereof |
| IL296992A (en) | 2020-04-03 | 2022-12-01 | Alector Llc | Methods for using anti-trem2 antibodies |
| CN115698717A (zh) | 2020-04-03 | 2023-02-03 | 基因泰克公司 | 癌症的治疗和诊断方法 |
| EP4132954A1 (en) | 2020-04-08 | 2023-02-15 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Use of cdon inhibitors for the treatment of endothelial dysfunction |
| WO2021209458A1 (en) | 2020-04-14 | 2021-10-21 | Ares Trading S.A. | Combination treatment of cancer |
| CA3172880A1 (en) | 2020-04-27 | 2021-11-04 | Sotirios Tsimikas | Isoform-independent antibodies to lipoprotein(a) |
| WO2021222167A1 (en) | 2020-04-28 | 2021-11-04 | Genentech, Inc. | Methods and compositions for non-small cell lung cancer immunotherapy |
| WO2021222533A1 (en) | 2020-04-30 | 2021-11-04 | Procisedx Inc. | Methods of detecting antibodies to sars-cov-2 |
| JP2023523760A (ja) | 2020-05-01 | 2023-06-07 | ノバルティス アーゲー | 免疫グロブリン変異体 |
| JP2023523794A (ja) | 2020-05-01 | 2023-06-07 | ノバルティス アーゲー | 人工操作免疫グロブリン |
| EP4142707A1 (en) | 2020-05-01 | 2023-03-08 | The Regents of the University of California | Inhibitors of alpha 2 beta 1 integrin and methods of use thereof |
| WO2021226290A1 (en) | 2020-05-05 | 2021-11-11 | 10X Genomics, Inc. | Methods for identification of antigen-binding molecules |
| EP3909601A1 (en) | 2020-05-11 | 2021-11-17 | LeukoCom GmbH | A novel antibody binding specifically to human ceacam1/3/5 and use thereof |
| WO2021231732A1 (en) | 2020-05-15 | 2021-11-18 | Bristol-Myers Squibb Company | Antibodies to garp |
| JP2023526529A (ja) | 2020-05-19 | 2023-06-21 | アンスティテュ・クリー | サイトカイン放出症候群の診断及び処置の方法 |
| EP4153633A1 (en) | 2020-05-19 | 2023-03-29 | Amgen Inc. | Mageb2 binding constructs |
| US20230220057A1 (en) | 2020-05-27 | 2023-07-13 | Staidson (Beijing) Biopharmaceuticals Co., Ltd. | Antibodies specifically recognizing nerve growth factor and uses thereof |
| EP4157459A1 (en) | 2020-05-27 | 2023-04-05 | Janssen Biotech, Inc. | Proteins comprising cd3 antigen binding domains and uses thereof |
| JP2023527972A (ja) | 2020-05-29 | 2023-07-03 | アムジエン・インコーポレーテツド | Ｃｄ３３及びｃｄ３に結合する二重特異性コンストラクトの有害作用軽減投与 |
| WO2021247618A1 (en) | 2020-06-02 | 2021-12-09 | 10X Genomics, Inc. | Enrichment of nucleic acid sequences |
| EP4161653A1 (en) | 2020-06-03 | 2023-04-12 | Bionecure Therapeutics, Inc. | Trophoblast cell-surface antigen-2 (trop-2) antibodies |
| GB202008651D0 (en) | 2020-06-09 | 2020-07-22 | Univ Newcastle | Method of identifying complement modulators |
| WO2021249969A1 (en) | 2020-06-10 | 2021-12-16 | Merck Patent Gmbh | Combination product for the treatment of cancer diseases |
| AU2021293038A1 (en) | 2020-06-16 | 2023-02-02 | F. Hoffmann-La Roche Ag | Methods and compositions for treating triple-negative breast cancer |
| EP4168118A1 (en) | 2020-06-18 | 2023-04-26 | Genentech, Inc. | Treatment with anti-tigit antibodies and pd-1 axis binding antagonists |
| JP2023531678A (ja) | 2020-06-22 | 2023-07-25 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 加齢筋肉、萎縮性筋肉、または異栄養性筋肉の処置のためのｔｓｐ－１阻害物質 |
| US20230305023A1 (en) | 2020-06-25 | 2023-09-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of treatment and diagnostic of pathological conditions associated with intense stress |
| MX2022015375A (es) | 2020-06-29 | 2023-01-16 | Genmab As | Conjugados de farmaco-anticuerpo anti-factor de tejido y su uso en el tratamiento de cancer. |
| WO2022006562A1 (en) | 2020-07-03 | 2022-01-06 | Dana-Farber Cancer Institute, Inc. | Multispecific coronavirus antibodies |
| EP4178624A2 (en) | 2020-07-07 | 2023-05-17 | Bionecure Therapeutics, Inc. | Maytansinoids as adc payloads and their use for the treatment of cancer |
| AU2021308586A1 (en) | 2020-07-17 | 2023-03-02 | Pfizer Inc. | Therapeutic antibodies and their uses |
| KR20230040331A (ko) | 2020-07-21 | 2023-03-22 | 알로젠 테라퓨틱스 인코포레이티드 | 강화된 신호 전달 및 활성을 갖는 키메라 항원 수용체 및 이의 용도 |
| JP2023536818A (ja) | 2020-07-29 | 2023-08-30 | ヤンセン バイオテツク，インコーポレーテツド | Ｈｌａ－ｇ抗原結合ドメインを含むタンパク質及びそれらの使用 |
| KR20230041071A (ko) | 2020-07-31 | 2023-03-23 | 제넨테크, 인크. | 항-인테그린 베타7 항체 제제 및 장치 |
| EP4189121A1 (en) | 2020-08-03 | 2023-06-07 | Genentech, Inc. | Diagnostic and therapeutic methods for lymphoma |
| CA3188728A1 (en) | 2020-08-07 | 2022-02-10 | Marc Nasoff | Immunoconjugates targeting cd46 and methods of use thereof |
| MX2023001707A (es) | 2020-08-10 | 2023-05-04 | Shanghai Xunbaihui Biotechnology Co Ltd | Composiciones y métodos para el tratamiento de enfermedades autoinmunes y cánceres por direccionamiento al miembro 8 de la superfamilia de inmunoglobulinas. |
| WO2022036146A1 (en) | 2020-08-12 | 2022-02-17 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
| EP4200338A1 (en) | 2020-08-20 | 2023-06-28 | Amgen Inc. | Antigen binding proteins with non-canonical disulfide in fab region |
| CN114106173A (zh) | 2020-08-26 | 2022-03-01 | 上海泰槿生物技术有限公司 | 抗ox40抗体、其药物组合物及应用 |
| WO2022047381A1 (en) | 2020-08-31 | 2022-03-03 | Genentech, Inc. | Methods for producing antibodies |
| EP4210722A1 (en) | 2020-09-07 | 2023-07-19 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods of treatment of inflammatory bowel diseases |
| AU2021339953A1 (en) | 2020-09-11 | 2023-05-18 | Medimmune Limited | Therapeutic b7-h4 binding molecules |
| CA3194182A1 (en) | 2020-09-12 | 2022-03-17 | Medimmune Limited | A scoring method for an anti-b7h4 antibody-drug conjugate therapy |
| EP4213947A2 (en) | 2020-09-16 | 2023-07-26 | President and Fellows of Harvard College | Methods of treating an individual that has failed an anti-pd-1/anti-pd-l1 therapy |
| US20230357418A1 (en) | 2020-09-17 | 2023-11-09 | Genentech, Inc. | Results of empacta: a randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of tocilizumab in hospitalized patients with covid-19 pneumonia |
| JP2023544387A (ja) | 2020-10-05 | 2023-10-23 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 虚血後の心臓リモデリングにおけるバイオマーカー及びバイオターゲットとしてのｇｄｆ３ |
| MX2023004088A (es) | 2020-10-07 | 2023-04-27 | Amgen Inc | Seleccion racional de bloques de construccion para el ensamblaje de anticuerpos multiespecificos. |
| WO2022074206A1 (en) | 2020-10-08 | 2022-04-14 | Affimed Gmbh | Trispecific binders |
| US12006550B2 (en) | 2020-10-12 | 2024-06-11 | University Of South Carolina | Targeting treatment for ADAM30 in pathological cells |
| EP3981789A1 (en) | 2020-10-12 | 2022-04-13 | Commissariat À L'Énergie Atomique Et Aux Énergies Alternatives | Anti-lilrb antibodies and uses thereof |
| US11926667B2 (en) | 2020-10-13 | 2024-03-12 | Janssen Biotech, Inc. | Bioengineered T cell mediated immunity, materials and other methods for modulating cluster of differentiation IV and/or VIII |
| WO2022079036A1 (en) | 2020-10-13 | 2022-04-21 | Almirall, S.A. | Bispecific molecules and methods of treatment using the same |
| WO2022081718A1 (en) | 2020-10-14 | 2022-04-21 | Five Prime Therapeutics, Inc. | Anti-c-c chemokine receptor 8 (ccr8) antibodies and methods of use thereof |
| CA3198049A1 (en) | 2020-10-15 | 2022-04-21 | UCB Biopharma SRL | Binding molecules that multimerise cd45 |
| US20230414700A1 (en) | 2020-10-15 | 2023-12-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Tg2 inhibitors for improving mucociliary clearance in respiratory diseases |
| US20230416346A1 (en) | 2020-10-21 | 2023-12-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | C-terminal sparc fragments for treating cancer |
| TW202233672A (zh) | 2020-10-22 | 2022-09-01 | 美商健生生物科技公司 | 包括類δ配體３（ＤＬＬ３）抗原結合區之蛋白質及其用途 |
| WO2022093981A1 (en) | 2020-10-28 | 2022-05-05 | Genentech, Inc. | Combination therapy comprising ptpn22 inhibitors and pd-l1 binding antagonists |
| WO2022093640A1 (en) | 2020-10-30 | 2022-05-05 | BioLegend, Inc. | Anti-nkg2c agents and compositions and methods for making and using the same |
| WO2022093641A1 (en) | 2020-10-30 | 2022-05-05 | BioLegend, Inc. | Anti-nkg2a agents and compositions and methods for making and using the same |
| CA3196550A1 (en) | 2020-11-02 | 2022-05-05 | Yan Lan | Combination treatment of cancer |
| US20230406909A1 (en) | 2020-11-02 | 2023-12-21 | Roche Diagnostics Operations, Inc. | Sars-cov-2 nucleocapsid antibodies |
| CA3196557A1 (en) | 2020-11-02 | 2022-05-05 | Ada SALA-HOJMAN | Combination treatment of cancer |
| US20240002519A1 (en) | 2020-11-05 | 2024-01-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of il-6 inhibitors for the treatment of acute chest syndrome in patients suffering from sickle cell disease |
| WO2022096633A1 (en) | 2020-11-06 | 2022-05-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosis and treating polycystic ovary syndrome (pcos) |
| TW202233680A (zh) | 2020-11-06 | 2022-09-01 | 德商安美基研究（慕尼黑）公司 | 具有增加的選擇性之多靶向性雙特異性抗原結合分子 |
| TW202233679A (zh) | 2020-11-06 | 2022-09-01 | 德商安美基研究（慕尼黑）公司 | 選擇性地與cldn6和cd3結合的多肽構建體 |
| AR124017A1 (es) | 2020-11-06 | 2023-02-01 | Amgen Res Munich Gmbh | Polipéptidos con perfil de recorte potenciado |
| KR20230104229A (ko) | 2020-11-06 | 2023-07-07 | 암젠 인크 | Cd3에 결합하는 폴리펩티드 구축물 |
| US20240002509A1 (en) | 2020-11-06 | 2024-01-04 | Novartis Ag | ANTIBODY Fc VARIANTS |
| CA3200603A1 (en) | 2020-11-10 | 2022-05-19 | Amgen Inc. | Novel linkers of multispecific antigen binding domains |
| EP4247849A2 (en) | 2020-11-17 | 2023-09-27 | Seagen Inc. | Methods of treating cancer with a combination of tucatinib and an anti-pd-1/anti-pd-l1 antibody |
| EP4251282A1 (en) | 2020-11-27 | 2023-10-04 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for diagnosis and monitoring of toxic epidermal necrolysis |
| US20240101681A1 (en) | 2020-12-02 | 2024-03-28 | Alector Llc | Methods of use of anti-sortilin antibodies |
| US20240052042A1 (en) | 2020-12-14 | 2024-02-15 | Novartis Ag | Reversal binding agents for anti-natriuretic peptide receptor i (npri) antibodies and uses thereof |
| EP4262868A1 (en) | 2020-12-17 | 2023-10-25 | Astrazeneca AB | Anti-il5r antibody formulations |
| WO2022140797A1 (en) | 2020-12-23 | 2022-06-30 | Immunowake Inc. | Immunocytokines and uses thereof |
| EP4281479A1 (en) | 2021-01-20 | 2023-11-29 | Oncoresponse, Inc. | Immunomodulatory antibodies and uses thereof |
| CA3208998A1 (en) | 2021-01-22 | 2022-07-28 | Steven Kerrigan | Treatment of coronavirus |
| US20240101717A1 (en) | 2021-01-22 | 2024-03-28 | Bionecure Therapeutics, Inc. | Anti-her-2/trop-2 constructs and uses thereof |
| AU2022214491A1 (en) | 2021-01-28 | 2023-09-14 | Janssen Biotech, Inc. | Psma binding proteins and uses thereof |
| WO2022186773A1 (en) | 2021-03-01 | 2022-09-09 | Aslan Pharmaceuticals Pte Ltd | TREATMENT OF ATOPIC DERMATITIS EMPLOYING ANTI-IL-13Rα1 ANTIBODY OR BINDING FRAGMENT THEREOF IN AN ALLERGIC POPULATION |
| WO2022186772A1 (en) | 2021-03-01 | 2022-09-09 | Aslan Pharmaceuticals Pte Ltd | TREATMENT OF ATOPIC DERMATITIS EMPLOYING ANTI-IL-13Rα1 ANTIBODY OR BINDING FRAGMENT THEREOF |
| MX2023010115A (es) | 2021-03-02 | 2023-11-09 | Cgrp Diagnostics Gmbh | Tratamiento y/o reducción de la aparición de la migraña. |
| AU2022232951A1 (en) | 2021-03-10 | 2023-10-19 | Immunowake Inc. | Immunomodulatory molecules and uses thereof |
| BR112023018353A2 (pt) | 2021-03-12 | 2024-02-06 | Janssen Biotech Inc | Método seguro e eficaz para tratamento da artrite psoriática com anticorpo específico anti-il23 |
| JP2024510588A (ja) | 2021-03-12 | 2024-03-08 | ヤンセン バイオテツク，インコーポレーテツド | 抗ｉｌ２３特異的抗体による、ｔｎｆ療法に対する不十分な応答を有する乾癬性関節炎患者を治療する方法 |
| KR20230156373A (ko) | 2021-03-15 | 2023-11-14 | 제넨테크, 인크. | 루푸스 신염의 치료 조성물 및 치료 방법 |
| JP2024516769A (ja) | 2021-03-18 | 2024-04-17 | メドイミューン・リミテッド | 治療用結合分子 |
| WO2022197947A1 (en) | 2021-03-18 | 2022-09-22 | Alector Llc | Anti-tmem106b antibodies and methods of use thereof |
| US20220315655A1 (en) | 2021-03-22 | 2022-10-06 | Novimmune Sa | Bispecific antibodies targeting cd47 and pd-l1 and methods of use thereof |
| EP4313309A1 (en) | 2021-03-22 | 2024-02-07 | Novimmune S.A. | Bispecific antibodies targeting cd47 and pd-l1 and methods of use thereof |
| JP2024512567A (ja) | 2021-03-23 | 2024-03-19 | インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） | Ｔ細胞リンパ腫の診断および治療方法 |
| US20240166738A1 (en) | 2021-03-23 | 2024-05-23 | Alector Llc | Anti-tmem106b antibodies for treating and preventing coronavirus infections |
| IL306132A (en) | 2021-03-24 | 2023-11-01 | Janssen Biotech Inc | Proteins containing CD3 antigen binding sites and uses thereof |
| TW202304986A (zh) | 2021-03-24 | 2023-02-01 | 美商健生生物科技公司 | 靶向cd22及cd79b的抗體 |
| EP4067381A1 (en) | 2021-04-01 | 2022-10-05 | Julius-Maximilians-Universität Würzburg | Novel tnfr2 binding molecules |
| AU2022246675A1 (en) | 2021-04-02 | 2023-10-19 | Amgen Inc. | Mageb2 binding constructs |
| EP4320153A1 (en) | 2021-04-09 | 2024-02-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of anaplastic large cell lymphoma |
| EP4319728A1 (en) | 2021-04-09 | 2024-02-14 | Genentech, Inc. | Combination therapy with a raf inhibitor and a pd-1 axis inhibitor |
| WO2022218998A1 (en) | 2021-04-13 | 2022-10-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for treating hepatitis b and d virus infection |
| WO2022225921A1 (en) | 2021-04-20 | 2022-10-27 | Amgen Inc. | Balanced charge distribution in electrostatic steering of chain pairing in multi-specific and monovalent igg molecule assembly |
| CA3216655A1 (en) | 2021-04-23 | 2022-10-27 | Amgen Inc. | Anti-tslp antibody compositions and uses thereof |
| AR125404A1 (es) | 2021-04-23 | 2023-07-12 | Amgen Inc | Anticuerpos anti-tslp modificados |
| WO2022232376A1 (en) | 2021-04-29 | 2022-11-03 | Amgen Inc. | Methods for reducing low molecular weight species of recombinantly-produced proteins |
| AR125490A1 (es) | 2021-04-30 | 2023-07-19 | Celgene Corp | Terapias de combinación que utilizan un anticuerpo anti-bcma conjugado a fármaco (adc) en combinación con un inhibidor de gamma secretasa (gsi) |
| JP2024517872A (ja) | 2021-05-03 | 2024-04-23 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | ＨＥＲ２を標的にするＦｃ抗原結合性フラグメント－薬物抱合体 |
| IL307638A (en) | 2021-05-05 | 2023-12-01 | Trianni Inc | Transgenic rodents expressing horse-rodent chimeric antibodies and methods of using them |
| EP4334354A1 (en) | 2021-05-06 | 2024-03-13 | Dana-Farber Cancer Institute, Inc. | Antibodies against alk and methods of use thereof |
| JP2024518369A (ja) | 2021-05-06 | 2024-05-01 | アムジェン リサーチ （ミュニック） ゲゼルシャフト ミット ベシュレンクテル ハフツング | 増殖性疾患で使用されるｃｄ２０及びｃｄ２２標的化抗原結合分子 |
| EP4340876A1 (en) | 2021-05-19 | 2024-03-27 | Sutro Biopharma, Inc. | Anti-folate receptor conjugate combination therapy with bevacizumab |
| WO2022248380A1 (en) | 2021-05-25 | 2022-12-01 | Merck Patent Gmbh | Egfr targeting fc antigen binding fragment-drug conjugates |
| WO2022256313A1 (en) | 2021-06-01 | 2022-12-08 | 10X Genomics, Inc. | Validation of a unique molecular identifier associated with a nucleic acid sequence of interest |
| EP4347647A1 (en) | 2021-06-01 | 2024-04-10 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Use of b cell depleting agents for the treatment of rheumatic heart disease |
| AU2022288571A1 (en) | 2021-06-07 | 2024-01-04 | Ares Trading S.A. | Combination treatment of cancer |
| KR20240019831A (ko) | 2021-06-11 | 2024-02-14 | 제넨테크, 인크. | St2 길항제를 이용하여 만성 폐쇄성 폐질환을 치료하는 방법 |
| EP4355786A1 (en) | 2021-06-16 | 2024-04-24 | Alector LLC | Bispecific anti-mertk and anti-pdl1 antibodies and methods of use thereof |
| EP4355783A1 (en) | 2021-06-16 | 2024-04-24 | Alector LLC | Monovalent anti-mertk antibodies and methods of use thereof |
| EP4359439A1 (en) | 2021-06-24 | 2024-05-01 | Yeda Research and Development Co. Ltd | Combination therapy for the treatment of cancer comprising an anti-egfr antibody and an axl-inhibitor |
| EP4367139A1 (en) | 2021-07-08 | 2024-05-15 | Staidson Biopharma Inc. | Antibodies specifically recognizing tnfr2 and uses thereof |
| KR20240034218A (ko) | 2021-07-09 | 2024-03-13 | 얀센 바이오테크 인코포레이티드 | 항-tnf 항체 조성물을 생산하기 위한 제조 방법 |
| IL309996A (en) | 2021-07-09 | 2024-03-01 | Janssen Biotech Inc | Production methods for the production of anti-TNF antibody compositions |
| IL309987A (en) | 2021-07-09 | 2024-03-01 | Janssen Biotech Inc | Production methods for the production of anti-IL12/IL23 antibody compositions |
| WO2023285362A1 (en) | 2021-07-12 | 2023-01-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of il-36 inhibitors for the treatment of netherton syndrome |
| WO2023285878A1 (en) | 2021-07-13 | 2023-01-19 | Aviation-Ophthalmology | Methods for detecting, treating, and preventing gpr68-mediated ocular diseases, disorders, and conditions |
| EP4371572A1 (en) | 2021-07-14 | 2024-05-22 | Staidson (Beijing) Biopharmaceuticals Co., Ltd. | Antibody that specifically recognizes cd40 and application thereof |
| WO2023009498A1 (en) | 2021-07-26 | 2023-02-02 | Abcuro, Inc. | Killer cell lectin-like receptor subfamily g member 1 (klrg1) depleting antibodies |
| WO2023007023A1 (en) | 2021-07-30 | 2023-02-02 | Affimed Gmbh | Duplexbodies |
| CA3227511A1 (en) | 2021-08-06 | 2023-02-09 | Lætitia LINARES | Methods for the treatment of cancer |
| GB202111905D0 (en) | 2021-08-19 | 2021-10-06 | UCB Biopharma SRL | Antibodies |
| WO2023028501A1 (en) | 2021-08-23 | 2023-03-02 | Immunitas Therapeutics, Inc. | Anti-cd161 antibodies and uses thereof |
| WO2023026205A1 (en) | 2021-08-24 | 2023-03-02 | Cgrp Diagnostics Gmbh | Preventative treatment of migraine |
| KR20240049342A (ko) | 2021-08-27 | 2024-04-16 | 얀센 바이오테크 인코포레이티드 | 항-psma 항체 및 이의 용도 |
| EP4244252B1 (en) | 2021-08-27 | 2024-05-29 | MedImmune Limited | Treatment of chronic obstructive pulmonary disease with an anti-interleukin-33 antibody |
| IL286430A (en) | 2021-09-14 | 2023-04-01 | Yeda Res & Dev | Multispecific antibodies for use in the treatment of diseases |
| WO2023041744A1 (en) | 2021-09-17 | 2023-03-23 | Institut Curie | Bet inhibitors for treating pab1 deficient cancer |
| WO2023046322A1 (en) | 2021-09-24 | 2023-03-30 | Janssen Pharmaceutica Nv | Proteins comprising cd20 binding domains, and uses thereof |
| WO2023048651A1 (en) | 2021-09-27 | 2023-03-30 | Aslan Pharmaceuticals Pte Ltd | Method for treatment of moderate to severe atoptic dematitis |
| WO2023048650A1 (en) | 2021-09-27 | 2023-03-30 | Aslan Pharmaceuticals Pte Ltd | TREATMENT OF PRURITIS EMPLOYING ANTI-IL13Rα1 ANTIBODY OR BINDING FRAGMENT THEREOF |
| WO2023052541A1 (en) | 2021-09-30 | 2023-04-06 | Imcheck Therapeutics | Combination of an anti-btn3a activating antibody and an il-2 agonist for use in therapy |
| WO2023069919A1 (en) | 2021-10-19 | 2023-04-27 | Alector Llc | Anti-cd300lb antibodies and methods of use thereof |
| WO2023072904A1 (en) | 2021-10-26 | 2023-05-04 | F. Hoffmann-La Roche Ag | Monoclonal antibodies specific for sars-cov-2 rbd |
| CA3234598A1 (en) | 2021-10-27 | 2023-05-04 | Daniel Olive | Butyrophilin (btn) 3a activating antibodies for use in methods for treating infectious disorders |
| WO2023076989A1 (en) | 2021-10-29 | 2023-05-04 | Seagen Inc. | Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-cd30 antibody-drug conjugate |
| IL312401A (en) | 2021-10-29 | 2024-06-01 | Janssen Biotech Inc | Methods for treating Crohn's disease with a specific anti-IL23 antibody |
| TW202333784A (zh) | 2021-10-29 | 2023-09-01 | 新加坡商亞獅康私人有限公司 | 抗ｉｌ１３ｒ抗體調配物 |
| AR127568A1 (es) | 2021-11-03 | 2024-02-07 | Affimed Gmbh | Ligandos biespecíficos de cd16a |
| CA3237018A1 (en) | 2021-11-03 | 2023-05-11 | Joachim Koch | Bispecific cd16a binders |
| CA3237090A1 (en) | 2021-11-05 | 2023-05-11 | Dana-Farber Cancer Institute, Inc. | Human broadly crossreactive influenza monoclonal antibodies and methods of use thereof |
| WO2023081898A1 (en) | 2021-11-08 | 2023-05-11 | Alector Llc | Soluble cd33 as a biomarker for anti-cd33 efficacy |
| AU2022386319A1 (en) | 2021-11-10 | 2024-05-23 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| AU2022387613A1 (en) | 2021-11-10 | 2024-05-30 | 10X Genomics, Inc. | Methods for identification of antigen-binding molecules |
| CA3238377A1 (en) | 2021-11-15 | 2023-05-19 | Janssen Biotech, Inc. | Methods of treating crohn's disease with anti-il23 specific antibody |
| WO2023089032A1 (en) | 2021-11-19 | 2023-05-25 | Institut Curie | Methods for the treatment of hrd cancer and brca-associated cancer |
| CA3239224A1 (en) | 2021-11-22 | 2023-05-25 | Janssen Biotech, Inc. | Compositions comprising enhanced multispecific binding agents for an immune response |
| CA3239216A1 (en) | 2021-11-23 | 2023-06-01 | Janssen Biotech, Inc. | Method of treating ulcerative colitis with anti-il23 specific antibody |
| CA3238936A1 (en) | 2021-11-24 | 2023-06-01 | Wayne A. Marasco | Antibodies against ctla-4 and methods of use thereof |
| WO2023102077A1 (en) | 2021-12-01 | 2023-06-08 | Sutro Biopharma, Inc. | Anti-folate receptor conjugate cancer therapy |
| WO2023099763A1 (en) | 2021-12-03 | 2023-06-08 | Institut Curie | Sirt6 inhibitors for use in treating resistant hrd cancer |
| WO2023104904A2 (en) | 2021-12-08 | 2023-06-15 | Genclis | The sars-cov-2 and variants use two independent cell receptors to replicate |
| WO2023110937A1 (en) | 2021-12-14 | 2023-06-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Depletion of nk cells for the treatment of adverse post-ischemic cardiac remodeling |
| WO2023111168A1 (en) | 2021-12-17 | 2023-06-22 | F. Hoffmann-La Roche Ag | A novel antibody for detection of amyloid beta 42 (aβ42) |
| CA3241395A1 (en) | 2021-12-17 | 2023-06-22 | Barbel SCHROFELBAUER | Antibodies and uses thereof |
| WO2023114543A2 (en) | 2021-12-17 | 2023-06-22 | Dana-Farber Cancer Institute, Inc. | Platform for antibody discovery |
| CA3223956A1 (en) | 2021-12-20 | 2023-06-29 | Vetoquinol Sa | Anti-canine interleukine-31-receptor a (il-31ra) antibodies and the uses thereof |
| AR128222A1 (es) | 2022-01-07 | 2024-04-10 | Johnson & Johnson Entpr Innovation Inc | MATERIALES Y MÉTODOS DE PROTEÍNAS DE UNIÓN A IL-1b |
| WO2023140780A1 (en) | 2022-01-24 | 2023-07-27 | Aslan Pharmaceuticals Pte Ltd. | Method of treating inflammatory disease |
| WO2023144303A1 (en) | 2022-01-31 | 2023-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Cd38 as a biomarker and biotarget in t-cell lymphomas |
| WO2023150181A1 (en) | 2022-02-01 | 2023-08-10 | President And Fellows Of Harvard College | Methods and compositions for treating cancer |
| WO2023152637A1 (en) | 2022-02-08 | 2023-08-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Neutralization of acyl-coa binding protein confers autophagy-dependent organ protection |
| WO2023152581A1 (en) | 2022-02-09 | 2023-08-17 | Janssen Biotech, Inc. | Method of treating cancer with psmaxcd3 antibody |
| TW202348252A (zh) | 2022-02-16 | 2023-12-16 | 英商梅迪繆思有限公司 | 用治療性結合分子治療癌症的組合療法 |
| TW202337905A (zh) | 2022-02-23 | 2023-10-01 | 新加坡商亞獅康私人有限公司 | 抗il13r抗體之糖基化形式 |
| WO2023164516A1 (en) | 2022-02-23 | 2023-08-31 | Alector Llc | Methods of use of anti-trem2 antibodies |
| WO2023164727A1 (en) | 2022-02-28 | 2023-08-31 | University Of Iowa Research Foundation | A-fabp antibodies for diagnosis and treatment of obesity-associated diseases |
| WO2023175614A1 (en) | 2022-03-15 | 2023-09-21 | Yeda Research And Development Co. Ltd. | Anti glucocorticoid-induced tnfr-related (gitr) protein antibodies and uses thereof |
| WO2023178357A1 (en) | 2022-03-18 | 2023-09-21 | Evolveimmune Therapeutics, Inc. | Bispecific antibody fusion molecules and methods of use thereof |
| TW202402790A (zh) | 2022-03-25 | 2024-01-16 | 英商梅迪繆思有限公司 | 減少呼吸系統感染之方法 |
| WO2023187707A1 (en) | 2022-03-30 | 2023-10-05 | Janssen Biotech, Inc. | Method of treating mild to moderate psoriasis with il-23 specific antibody |
| US20230364020A1 (en) | 2022-04-01 | 2023-11-16 | Genentech, Inc. | Hydroxypropyl methyl cellulose derivatives to stabilize polypeptides |
| US20230416361A1 (en) | 2022-04-06 | 2023-12-28 | Mirobio Limited | Engineered cd200r antibodies and uses thereof |
| GB202205203D0 (en) | 2022-04-08 | 2022-05-25 | UCB Biopharma SRL | Combination with inhibitor |
| GB202205200D0 (en) | 2022-04-08 | 2022-05-25 | Ucb Biopharma Sprl | Combination with chemotherapy |
| WO2023198648A1 (en) | 2022-04-11 | 2023-10-19 | Institut National de la Santé et de la Recherche Médicale | Methods for the diagnosis and treatment of t-cell malignancies |
| WO2023198874A1 (en) | 2022-04-15 | 2023-10-19 | Institut National de la Santé et de la Recherche Médicale | Methods for the diagnosis and treatment of t cell-lymphomas |
| TW202400658A (zh) | 2022-04-26 | 2024-01-01 | 瑞士商諾華公司 | 靶向ｉｌ—１３和ｉｌ—１８的多特異性抗體 |
| TW202408583A (zh) | 2022-05-06 | 2024-03-01 | 丹麥商珍美寶股份有限公司 | 使用抗組織因子抗體－藥物共軛體以治療癌症之方法 |
| WO2023218027A1 (en) | 2022-05-12 | 2023-11-16 | Amgen Research (Munich) Gmbh | Multichain multitargeting bispecific antigen-binding molecules of increased selectivity |
| US20230374122A1 (en) | 2022-05-18 | 2023-11-23 | Janssen Biotech, Inc. | Method for Evaluating and Treating Psoriatic Arthritis with IL23 Antibody |
| WO2023235415A1 (en) | 2022-06-01 | 2023-12-07 | Genentech, Inc. | Method to identify a patient with an increased likelihood of chemotherapy-induced peripheral neuropathy |
| WO2023240058A2 (en) | 2022-06-07 | 2023-12-14 | Genentech, Inc. | Prognostic and therapeutic methods for cancer |
| WO2023245105A1 (en) | 2022-06-17 | 2023-12-21 | Genentech, Inc. | Use of kosmotropes to enhance yield of an affinity chromatography purification step |
| WO2024003310A1 (en) | 2022-06-30 | 2024-01-04 | Institut National de la Santé et de la Recherche Médicale | Methods for the diagnosis and treatment of acute lymphoblastic leukemia |
| WO2024020051A1 (en) | 2022-07-19 | 2024-01-25 | BioLegend, Inc. | Anti-cd157 antibodies, antigen-binding fragments thereof and compositions and methods for making and using the same |
| WO2024020407A1 (en) | 2022-07-19 | 2024-01-25 | Staidson Biopharma Inc. | Antibodies specifically recognizing b- and t-lymphocyte attenuator (btla) and uses thereof |
| WO2024018046A1 (en) | 2022-07-22 | 2024-01-25 | Institut National de la Santé et de la Recherche Médicale | Garp as a biomarker and biotarget in t-cell malignancies |
| WO2024026471A1 (en) | 2022-07-29 | 2024-02-01 | Alector Llc | Cd98hc antigen-binding domains and uses therefor |
| WO2024023283A1 (en) | 2022-07-29 | 2024-02-01 | Institut National de la Santé et de la Recherche Médicale | Lrrc33 as a biomarker and biotarget in cutaneous t-cell lymphomas |
| WO2024026447A1 (en) | 2022-07-29 | 2024-02-01 | Alector Llc | Anti-gpnmb antibodies and methods of use thereof |
| WO2024026472A2 (en) | 2022-07-29 | 2024-02-01 | Alector Llc | Transferrin receptor antigen-binding domains and uses therefor |
| WO2024028731A1 (en) | 2022-08-05 | 2024-02-08 | Janssen Biotech, Inc. | Transferrin receptor binding proteins for treating brain tumors |
| WO2024028732A1 (en) | 2022-08-05 | 2024-02-08 | Janssen Biotech, Inc. | Cd98 binding constructs for treating brain tumors |
| WO2024039672A2 (en) | 2022-08-15 | 2024-02-22 | Dana-Farber Cancer Institute, Inc. | Antibodies against msln and methods of use thereof |
| WO2024039670A1 (en) | 2022-08-15 | 2024-02-22 | Dana-Farber Cancer Institute, Inc. | Antibodies against cldn4 and methods of use thereof |
| US20240092859A1 (en) | 2022-08-18 | 2024-03-21 | Immunocore Ltd | T cell receptors and fusion proteins thereof |
| WO2024040114A2 (en) | 2022-08-18 | 2024-02-22 | BioLegend, Inc. | Anti-axl antibodies, antigen-binding fragments thereof and methods for making and using the same |
| WO2024043837A1 (en) | 2022-08-26 | 2024-02-29 | Aslan Pharmaceuticals Pte Ltd | High concentration anti-il13r antibody formulation |
| WO2024042212A1 (en) | 2022-08-26 | 2024-02-29 | Medimmune Limited | Treatment of asthma with an anti-interleukin-33 antibody |
| WO2024050354A1 (en) | 2022-08-31 | 2024-03-07 | Washington University | Alphavirus antigen binding antibodies and uses thereof |
| WO2024054157A1 (en) | 2022-09-06 | 2024-03-14 | Aslan Pharmaceuticals Pte Ltd | Treatment for sleep loss or sleep disturbance in patients with dermatitis |
| WO2024052922A1 (en) | 2022-09-11 | 2024-03-14 | Yeda Research And Development Co. Ltd. | Anti-klk4 antibodies and uses thereof |
| WO2024059183A1 (en) | 2022-09-14 | 2024-03-21 | President And Fellows Of Harvard College | Methods and compositions for modulation of piezo1 in the treatment of cancer |
| WO2024059675A2 (en) | 2022-09-14 | 2024-03-21 | Amgen Inc. | Bispecific molecule stabilizing composition |
| WO2024074498A1 (en) | 2022-10-04 | 2024-04-11 | Imcheck Therapeutics | Combination of a btn3a activating antibody, a bcl2 inhibitor and hypomethylating agent for use in treating cancer |
| WO2024079192A1 (en) | 2022-10-12 | 2024-04-18 | Institut National de la Santé et de la Recherche Médicale | Cd81 as a biomarker and biotarget in t-cell malignancies |
| WO2024086796A1 (en) | 2022-10-20 | 2024-04-25 | Alector Llc | Anti-ms4a4a antibodies with amyloid-beta therapies |
| WO2024084052A1 (en) | 2022-10-21 | 2024-04-25 | Novimmune Sa | Pd-l1xcd28 bispecific antibodies for immune checkpoint-dependent t cell activation |
| WO2024092064A1 (en) | 2022-10-26 | 2024-05-02 | Amgen Inc. | Anti-tslp antibody compositions and uses thereof |
| WO2024097796A1 (en) | 2022-11-02 | 2024-05-10 | Kira Pharmaceuticals (Us) Llc | Anti-c5 antibody fused to factor h for use in the treatment of complement-mediated diseases |
| WO2024097441A1 (en) | 2022-11-02 | 2024-05-10 | Kira Pharmaceuticals (Us) Llc | Anti-c5 antibody fused to factor h for use in the treatment of complement-mediated diseases |
| WO2024102734A1 (en) | 2022-11-08 | 2024-05-16 | Genentech, Inc. | Compositions and methods of treating childhood onset idiopathic nephrotic syndrome |
| US20240199734A1 (en) | 2022-11-22 | 2024-06-20 | Janssen Biotech, Inc. | Method of Treating Ulcerative Colitis with Anti-IL23 Specific Antibody |
| WO2024115935A1 (en) | 2022-11-29 | 2024-06-06 | Inserm | Methods for the treatment of b-cell lymphoma using cd39 inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE141646T1 (de) * | 1986-04-09 | 1996-09-15 | Genzyme Corp | Genetisch transformierte tiere, die ein gewünschtes protein in milch absondern |
| GB8615942D0 (en) * | 1986-06-30 | 1986-08-06 | Animal & Food Research Council | Peptide production |
| WO1988001648A1 (en) * | 1986-08-28 | 1988-03-10 | Immunex Corporation | Expression of heterologous proteins by transgenic lactating mammals |
| EP0273085A1 (en) * | 1986-12-29 | 1988-07-06 | IntraCel Corporation | A method for internalizing nucleic acids into eukaryotic cells |
| US4873316A (en) * | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
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1988
- 1988-10-12 GB GB888823869A patent/GB8823869D0/en active Pending
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- 1989-10-12 KR KR1019900701247A patent/KR0164608B1/ko not_active IP Right Cessation
- 1989-10-12 DE DE68926508T patent/DE68926508T2/de not_active Expired - Lifetime
- 1989-10-12 JP JP51081289A patent/JP3484442B2/ja not_active Expired - Lifetime
- 1989-10-12 AT AT89911584T patent/ATE138104T1/de not_active IP Right Cessation
- 1989-10-12 WO PCT/GB1989/001207 patent/WO1990004036A1/en active IP Right Grant
- 1989-10-12 AU AU44173/89A patent/AU4417389A/en not_active Abandoned
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1994
- 1994-08-05 US US08/286,399 patent/US5545807A/en not_active Expired - Lifetime
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| WO1990004036A1 (en) | 1990-04-19 |
| ATE138104T1 (de) | 1996-06-15 |
| JP3484442B2 (ja) | 2004-01-06 |
| GB8823869D0 (en) | 1988-11-16 |
| EP0438474B1 (en) | 1996-05-15 |
| DE68926508D1 (de) | 1996-06-20 |
| KR0164608B1 (ko) | 1999-01-15 |
| US5545807A (en) | 1996-08-13 |
| JPH04500911A (ja) | 1992-02-20 |
| JP3871997B2 (ja) | 2007-01-24 |
| AU4417389A (en) | 1990-05-01 |
| KR900702049A (ko) | 1990-12-05 |
| EP0438474A1 (en) | 1991-07-31 |
| DE68926508T2 (de) | 1996-10-31 |
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