ATE502106T1 - Verfahren zur klonierung von nichtmenschliche säugern unter verwendung von reprogrammiertem donorchromatin oder donorzellen - Google Patents
Verfahren zur klonierung von nichtmenschliche säugern unter verwendung von reprogrammiertem donorchromatin oder donorzellenInfo
- Publication number
- ATE502106T1 ATE502106T1 AT01992388T AT01992388T ATE502106T1 AT E502106 T1 ATE502106 T1 AT E502106T1 AT 01992388 T AT01992388 T AT 01992388T AT 01992388 T AT01992388 T AT 01992388T AT E502106 T1 ATE502106 T1 AT E502106T1
- Authority
- AT
- Austria
- Prior art keywords
- donor
- reprogrammed
- human mammals
- chromatin
- cells
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 241000124008 Mammalia Species 0.000 title abstract 2
- 238000010367 cloning Methods 0.000 title abstract 2
- 108010077544 Chromatin Proteins 0.000 title 1
- 210000003483 chromatin Anatomy 0.000 title 1
- 210000000349 chromosome Anatomy 0.000 abstract 2
- 238000003780 insertion Methods 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 210000004940 nucleus Anatomy 0.000 abstract 1
- 210000000287 oocyte Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
- C12N15/8771—Bovine embryos
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0273—Cloned vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/102—Caprine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/103—Ovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/107—Rabbit
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/10—Conditioning of cells for in vitro fecondation or nuclear transfer
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Environmental Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25815100P | 2000-12-22 | 2000-12-22 | |
PCT/US2001/050406 WO2002051997A1 (en) | 2000-12-22 | 2001-12-21 | Methods for cloning mammals using reprogrammed donor chromatin or donor cells |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE502106T1 true ATE502106T1 (de) | 2011-04-15 |
Family
ID=22979301
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01992388T ATE502106T1 (de) | 2000-12-22 | 2001-12-21 | Verfahren zur klonierung von nichtmenschliche säugern unter verwendung von reprogrammiertem donorchromatin oder donorzellen |
Country Status (13)
Country | Link |
---|---|
US (2) | US7253334B2 (de) |
EP (1) | EP1356035B1 (de) |
JP (1) | JP4420604B2 (de) |
KR (1) | KR100832943B1 (de) |
CN (1) | CN100448991C (de) |
AT (1) | ATE502106T1 (de) |
AU (1) | AU2002232858B2 (de) |
CA (1) | CA2427322C (de) |
DE (1) | DE60144248D1 (de) |
HK (1) | HK1066028A1 (de) |
MX (1) | MXPA03005624A (de) |
NZ (1) | NZ525607A (de) |
WO (1) | WO2002051997A1 (de) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110171185A1 (en) * | 1999-06-30 | 2011-07-14 | Klimanskaya Irina V | Genetically intact induced pluripotent cells or transdifferentiated cells and methods for the production thereof |
US20030027331A1 (en) * | 2000-11-30 | 2003-02-06 | Yan Wen Liang | Isolated homozygous stem cells, differentiated cells derived therefrom, and materials and methods for making and using same |
AU2002232858B2 (en) * | 2000-12-22 | 2007-01-11 | Sab, Llc | Methods for cloning mammals using reprogrammed donor chromatin or donor cells |
US7491534B2 (en) * | 2000-12-22 | 2009-02-17 | Kirin Holdings Kabushiki Kaisha | Methods for altering cell fate to generate T-cells specific for an antigen of interest |
US20020142397A1 (en) * | 2000-12-22 | 2002-10-03 | Philippe Collas | Methods for altering cell fate |
WO2002057429A2 (en) * | 2001-01-02 | 2002-07-25 | Stemron, Inc. | A method for producing a population of homozygous stem cells having a pre-selected immunophenotype and/or genotype |
CA2450652A1 (en) * | 2001-06-14 | 2002-12-27 | Infigen, Inc. | Methods for cloning mammals using remodeling factors |
US20030044976A1 (en) * | 2001-08-27 | 2003-03-06 | Advanced Cell Technology | De-differentiation and re-differentiation of somatic cells and production of cells for cell therapies |
WO2003018767A2 (en) * | 2001-08-27 | 2003-03-06 | Advanced Cell Technology, Inc. | Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies |
US20050090004A1 (en) * | 2003-01-16 | 2005-04-28 | Sayre Chauncey B. | Stem cell maturation for all tissue lines |
US20030134422A1 (en) * | 2002-01-16 | 2003-07-17 | Sayre Chauncey Bigelow | Stem cell maturation for all tissue lines |
US20050170506A1 (en) * | 2002-01-16 | 2005-08-04 | Primegen Biotech Llc | Therapeutic reprogramming, hybrid stem cells and maturation |
AU2003290689A1 (en) * | 2002-11-08 | 2004-06-03 | Kyowa Hakko Kirin Co., Ltd. | Transgenic ungulates having reduced prion protein activity and uses thereof |
KR20060057528A (ko) * | 2003-04-09 | 2006-05-26 | 마제-위민스 헬스 코퍼레이션 | 동물에서 체세포 핵 전이와 연관된 유사분열 방추 결함을교정하는 방법 |
US20060037086A1 (en) * | 2003-04-09 | 2006-02-16 | Schatten Gerald P | Methods for correcting mitotic spindle defects and optimizing preimplantation embryonic developmental rates associated with somatic cell nuclear transfer in animals |
FR2855183B1 (fr) | 2003-05-23 | 2005-08-12 | Agronomique Inst Nat Rech | Procede de clonage du rat par transfert nucleaire |
US7420099B2 (en) | 2004-04-22 | 2008-09-02 | Kirin Holdings Kabushiki Kaisha | Transgenic animals and uses thereof |
FR2885368A1 (fr) * | 2005-05-04 | 2006-11-10 | Fred Zacouto | Systemes et procedes de regeneration cellulaire et utilisations de telles cellules regenerees |
ES2933478T3 (es) | 2005-08-03 | 2023-02-09 | Astellas Inst For Regenerative Medicine | Métodos mejorados de reprogramación de células somáticas animales |
EP1948787A4 (de) * | 2005-11-18 | 2008-12-31 | Imgen Co Ltd | Okadainsäure enthaltende zusammensetzung für die undifferenzierte proliferation embryonaler stammzellen |
KR100710008B1 (ko) * | 2006-02-02 | 2007-04-23 | 충남대학교산학협력단 | Streptolysin O의 체세포 처리에 의한 복제효율 증진 방법 |
WO2008020329A2 (en) | 2006-05-11 | 2008-02-21 | Regenics As | Administration of cells and cellular extracts for rejuvenation |
WO2008017097A1 (en) * | 2006-08-10 | 2008-02-14 | Merck Patent Gmbh | Method for isolating cells |
US20090111184A1 (en) * | 2007-10-24 | 2009-04-30 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Chromosome selection |
US20090111764A1 (en) * | 2007-10-25 | 2009-04-30 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Mitochondrial selection |
US20090111185A1 (en) * | 2007-10-26 | 2009-04-30 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Female genome selection |
WO2009136291A2 (en) * | 2008-05-09 | 2009-11-12 | Regenics As | Cellular extracts |
CA2780945C (en) | 2009-11-17 | 2018-09-04 | Kyowa Hakko Kirin Co., Ltd. | Human artificial chromosome vector |
US9420770B2 (en) | 2009-12-01 | 2016-08-23 | Indiana University Research & Technology Corporation | Methods of modulating thrombocytopenia and modified transgenic pigs |
WO2011138687A2 (en) | 2010-05-06 | 2011-11-10 | Regenics As | Use of cellular extracts for skin rejuvenation |
AU2011316830A1 (en) | 2010-10-22 | 2013-05-02 | Biotime Inc. | Methods of modifying transcriptional regulatory networks in stem cells |
US9700596B2 (en) | 2011-03-04 | 2017-07-11 | The Regents Of The University Of California | Locally released growth factors to mediate motor recovery after stroke |
WO2013010045A1 (en) | 2011-07-12 | 2013-01-17 | Biotime Inc. | Novel methods and formulations for orthopedic cell therapy |
EP2716751A1 (de) | 2012-10-08 | 2014-04-09 | BioTime, Inc. | Differenzierte Nachkommenschaft von klonalen Vorläuferzelllinien |
KR101662734B1 (ko) * | 2012-11-08 | 2016-10-06 | 한국생명공학연구원 | 스트렙토라이신 o의 처리에 의한 형질전환 동물의 생산성 향상 방법 |
AU2013356930B2 (en) | 2012-12-10 | 2017-01-05 | Regenics As | Use of egg cellular extracts for skin rejuvenation |
CN113648323A (zh) | 2013-06-05 | 2021-11-16 | 再生疗法有限公司 | 用于哺乳动物物种中诱导性组织再生的组合物和方法 |
US11078462B2 (en) | 2014-02-18 | 2021-08-03 | ReCyte Therapeutics, Inc. | Perivascular stromal cells from primate pluripotent stem cells |
US10240127B2 (en) | 2014-07-03 | 2019-03-26 | ReCyte Therapeutics, Inc. | Exosomes from clonal progenitor cells |
US11072649B2 (en) | 2015-11-25 | 2021-07-27 | Sab, Llc | Systems and methods for the production of human polyclonal antibodies |
CA3202332A1 (en) | 2015-12-07 | 2017-06-15 | Agex Therapeutics, Inc. | Methods for the re-derivation of diverse pluripotent stem cell-derived brown fat cells |
CN106489843A (zh) * | 2016-11-14 | 2017-03-15 | 深圳职业技术学院 | 一种可无需解剖判断黄喉拟水龟胚胎发育时相的方法 |
CN109988745A (zh) * | 2018-01-03 | 2019-07-09 | 复旦大学 | 一种细胞核的提取方法 |
WO2022046286A1 (en) | 2020-08-31 | 2022-03-03 | SAB Biotherapeutics, Inc. | Ungulate-derived polyclonal immunoglobulin specific for coronavirus protein and uses thereof |
Family Cites Families (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1293460C (en) | 1985-10-07 | 1991-12-24 | Brian Lee Sauer | Site-specific recombination of dna in yeast |
US4994384A (en) | 1986-12-31 | 1991-02-19 | W. R. Grace & Co.-Conn. | Multiplying bovine embryos |
US5470560A (en) | 1987-01-20 | 1995-11-28 | Genentech, Inc. | Method for evaluating immunogenicity |
EP0832981A1 (de) | 1987-02-17 | 1998-04-01 | Pharming B.V. | DNA-Sequenzen die Proteine zwecks effizienter Abscheidung zur Milchdrüse leiten |
US5057420A (en) | 1987-06-05 | 1991-10-15 | Granada Biosciences, Inc. | Bovine nuclear transplantation |
US5750172A (en) | 1987-06-23 | 1998-05-12 | Pharming B.V. | Transgenic non human mammal milk |
US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
US5213979A (en) | 1987-12-30 | 1993-05-25 | W. R. Grace & Co.-Conn. | In vitro culture of bovine embryos |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
US5633076A (en) | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
DE4000939A1 (de) | 1990-01-15 | 1991-07-18 | Brem Gottfried Prof Dr Dr | Verfahren zur antikoerpergewinnung |
US5160312A (en) | 1990-02-09 | 1992-11-03 | W. R. Grace & Co.-Conn. | Cryopreservation process for direct transfer of embryos |
US5614396A (en) | 1990-06-14 | 1997-03-25 | Baylor College Of Medicine | Methods for the genetic modification of endogenous genes in animal cells by homologous recombination |
US5096822A (en) | 1990-07-26 | 1992-03-17 | W. R. Grace & Co.- Conn. | Bovine embryo medium |
US5453366A (en) | 1990-07-26 | 1995-09-26 | Sims; Michele M. | Method of cloning bovine embryos |
KR100272077B1 (ko) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물 |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
WO1992003917A1 (en) | 1990-08-29 | 1992-03-19 | Genpharm International | Homologous recombination in mammalian cells |
US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
WO1992015694A1 (en) | 1991-03-08 | 1992-09-17 | The Salk Institute For Biological Studies | Flp-mediated gene modification in mammalian cells, and compositions and cells useful therefor |
US5240840A (en) | 1991-04-05 | 1993-08-31 | Regents Of The University Of Michigan | Dna superfragment cloning |
AU2515992A (en) | 1991-08-20 | 1993-03-16 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
AU2778992A (en) | 1991-10-07 | 1993-05-03 | Idaho Research Foundation Inc., The | Genetic construct for selection of homologous recombinants on a single selective medium |
ATE288484T1 (de) | 1991-11-14 | 2005-02-15 | Charles Weissmann | Transgene nicht-menschliche tiere ohne prionprotein |
EP0626999A4 (en) | 1992-01-24 | 1997-04-09 | Life Technologies Inc | Modulation of enzyme activities in the -i(in vivo) cloning of dna. |
US5843643A (en) | 1992-02-21 | 1998-12-01 | Ratner; Paul L. | Site-specific transfection of eukaryotic cells using polypeptide-linked recombinant nucleic acid |
US5763240A (en) | 1992-04-24 | 1998-06-09 | Sri International | In vivo homologous sequence targeting in eukaryotic cells |
US5654183A (en) | 1992-07-27 | 1997-08-05 | California Institute Of Technology | Genetically engineered mammalian neural crest stem cells |
US6107543A (en) | 1992-08-20 | 2000-08-22 | Infigen, Inc. | Culture of totipotent embryonic inner cells mass cells and production of bovine animals |
US5480772A (en) | 1993-02-03 | 1996-01-02 | Brandeis University | In vitro activation of a nucleus |
US5496720A (en) | 1993-02-10 | 1996-03-05 | Susko-Parrish; Joan L. | Parthenogenic oocyte activation |
WO1994021799A1 (en) | 1993-03-16 | 1994-09-29 | Austin Research Institute | USE OF PORCINE GAL α(1,3) GALACTOSYL TRANSFERASE IN XENOGRAFT THERAPIES |
WO1995015972A1 (en) | 1993-12-09 | 1995-06-15 | Thomas Jefferson University | Compounds and methods for site-directed mutations in eukaryotic cells |
US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
US6001654A (en) | 1994-01-28 | 1999-12-14 | California Institute Of Technology | Methods for differentiating neural stem cells to neurons or smooth muscle cells using TGT-β super family growth factors |
AU2233295A (en) | 1994-04-13 | 1995-11-10 | Biotransplant Incorporated | Alpha(1,3) galactosyltransferase negative swine |
US5723331A (en) | 1994-05-05 | 1998-03-03 | Genzyme Corporation | Methods and compositions for the repair of articular cartilage defects in mammals |
US5583016A (en) | 1994-07-07 | 1996-12-10 | Geron Corporation | Mammalian telomerase |
US5876979A (en) | 1994-07-07 | 1999-03-02 | Cold Spring Harbor Laboratory | RNA component of mouse, rat, Chinese hamster and bovine telomerase |
US5780296A (en) | 1995-01-17 | 1998-07-14 | Thomas Jefferson University | Compositions and methods to promote homologous recombination in eukaryotic cells and organisms |
US5776744A (en) | 1995-06-07 | 1998-07-07 | Yale University | Methods and compositions for effecting homologous recombination |
US5952222A (en) * | 1995-08-04 | 1999-09-14 | The Board Of Trustees Of The University Of Arkansas | Functional enucleation of bovine oocytes |
US5733730A (en) | 1995-08-25 | 1998-03-31 | The Rockefeller University | Telomere repeat binding factor and diagnostic and therapeutic use thereof |
GB9517780D0 (en) | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
US5695977A (en) | 1995-08-31 | 1997-12-09 | Genetic Information Research Institute | Site directed recombination |
US7304204B2 (en) | 1995-08-31 | 2007-12-04 | Roslin Institute | Ungulates produced by nuclear transfer of G1 cells |
GB9517779D0 (en) | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
US5801030A (en) | 1995-09-01 | 1998-09-01 | Genvec, Inc. | Methods and vectors for site-specific recombination |
JP2848286B2 (ja) * | 1995-09-29 | 1999-01-20 | ヤマハ株式会社 | カラオケ装置 |
US5679523A (en) | 1995-11-16 | 1997-10-21 | The Board Of Trustees Of The Leland Stanford Junior University | Method for concurrent disruption of expression of multiple alleles of mammalian genes |
US5905042A (en) | 1996-04-01 | 1999-05-18 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Cultured inner cell mass cell lines derived from bovine or porcine embryos |
US20060021070A1 (en) * | 1996-04-01 | 2006-01-26 | University of Massachusetts, a Public Institution of Higher Education of the Commonwealth of MA | Production of chimeric bovine or porcine animals using cultured inner cell mass |
US5770422A (en) | 1996-07-08 | 1998-06-23 | The Regents Of The University Of California | Human telomerase |
US20020194637A1 (en) * | 2001-06-06 | 2002-12-19 | University Of Massachussetts | Embryonic or stem-like cell lines produced by cross species nuclear transplantation |
EP0941310A1 (de) | 1996-10-11 | 1999-09-15 | THE TEXAS A&M UNIVERSITY SYSTEM | Verfahren zur erzeugung primordialer keimzellen und transgene tierarten |
US6235969B1 (en) * | 1997-01-10 | 2001-05-22 | University Of Massachusetts | Cloning pigs using donor nuclei from non-quiescent differentiated cells |
US6215041B1 (en) | 1997-01-10 | 2001-04-10 | University Of Mmassachusetts | Cloning using donor nuclei from a non-quiesecent somatic cells |
US20010039667A1 (en) | 1997-01-10 | 2001-11-08 | University Of Massachusetts | Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including parkinson's disease |
US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
US20020012655A1 (en) * | 1997-01-10 | 2002-01-31 | Steven L. Stice | Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including parkinson's disease |
US6011197A (en) * | 1997-03-06 | 2000-01-04 | Infigen, Inc. | Method of cloning bovines using reprogrammed non-embryonic bovine cells |
US5830698A (en) | 1997-03-14 | 1998-11-03 | Idec Pharmaceuticals Corporation | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
AU7979098A (en) * | 1997-06-18 | 1999-01-04 | Curators Of The University Of Missouri, The | Complete activation of mammalian oocytes |
NZ502129A (en) * | 1997-07-03 | 2005-02-25 | Univ Massachusetts | Cloning using donor nuclei from non-serum starved, differentiated cells |
US20020019993A1 (en) | 1998-01-21 | 2002-02-14 | Teruhiko Wakayama | Full term development of animals from enucleated oocytes reconstituted with adult somatic cell nuclei |
WO1999041403A1 (en) * | 1998-02-12 | 1999-08-19 | The Regents Of The University Of California | Compositions for receptor/liposome mediated transfection and methods of using same |
US6258998B1 (en) | 1998-11-24 | 2001-07-10 | Infigen, Inc. | Method of cloning porcine animals |
US20020012660A1 (en) | 1999-03-04 | 2002-01-31 | Alan Colman | Method of preparing a somatic cells for nuclear transfer |
ATE394029T1 (de) * | 1999-05-06 | 2008-05-15 | Stem Cell Sciences Australia P | Verfahren der zellreprogrammierung durch herstellung eines heterokaryons |
AUPQ025999A0 (en) * | 1999-05-10 | 1999-06-03 | Garelag Pty Ltd | Non enucleation and enucleation post fusion of nuclear transfer embryos |
AU782286B2 (en) * | 1999-06-30 | 2005-07-14 | Advanced Cell Technology, Inc. | Cytoplasmic transfer to de-differentiate recipient cells |
US20030129745A1 (en) * | 1999-10-28 | 2003-07-10 | Robl James M. | Gynogenetic or androgenetic production of pluripotent cells and cell lines, and use thereof to produce differentiated cells and tissues |
JP2003512848A (ja) * | 1999-11-02 | 2003-04-08 | ユニバーシティ オブ マサチューセッツ、アズ リプリゼンティッド バイ イッツ アマースト キャンパス | 遺伝的診断、修飾および増殖のための一倍体ゲノムの使用 |
US7074983B2 (en) * | 1999-11-19 | 2006-07-11 | Kirin Beer Kabushiki Kaisha | Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin |
US7414170B2 (en) * | 1999-11-19 | 2008-08-19 | Kirin Beer Kabushiki Kaisha | Transgenic bovines capable of human antibody production |
AU2103601A (en) | 1999-12-17 | 2001-06-25 | Oregon Health And Science University | Methods for producing transgenic animals |
JP2003518936A (ja) | 2000-01-04 | 2003-06-17 | ユニバーシティ オブ コネチカット | 長期間培養された雄または雌の体細胞核の、人為的に誘導される遺伝子改変を含む、除核レシピエント細胞への移植による、標的遺伝子改変を有する動物をクローニングする方法。 |
CA2403344C (en) | 2000-03-15 | 2013-05-21 | The University Of Georgia Research Foundation, Inc. | Effective nuclear reprogramming in mammals |
IL151758A0 (en) * | 2000-03-24 | 2003-04-10 | Univ Massachusetts | Prion-free transgenic ungulates |
EP1328152B1 (de) | 2000-09-28 | 2007-04-25 | Sangamo Biosciences Inc. | Kernumprogrammierung bei iswi und ähnlichen chromatinremodellierenden atpasen |
AU2002232858B2 (en) * | 2000-12-22 | 2007-01-11 | Sab, Llc | Methods for cloning mammals using reprogrammed donor chromatin or donor cells |
US20020142397A1 (en) * | 2000-12-22 | 2002-10-03 | Philippe Collas | Methods for altering cell fate |
US7491534B2 (en) * | 2000-12-22 | 2009-02-17 | Kirin Holdings Kabushiki Kaisha | Methods for altering cell fate to generate T-cells specific for an antigen of interest |
JP2002262716A (ja) * | 2001-03-07 | 2002-09-17 | National Agricultural Research Organization | 株化細胞を用いて家畜個体を作出する方法 |
US20030027330A1 (en) * | 2001-04-02 | 2003-02-06 | Robert Lanza | Method for facilitating the production of differentiated cell types and tissues from embryonic and adult pluripotent and multipotent cells |
US20060083722A1 (en) * | 2001-07-18 | 2006-04-20 | Advanced Cell Technology, Inc | Methods and compositions for cell therapy |
US20040139489A1 (en) * | 2001-10-05 | 2004-07-15 | Robert Lanza | Method for generating cloned animals using chromosome shuffling |
AU2003233679A1 (en) * | 2002-05-23 | 2003-12-12 | Advanced Cell Technology, Inc. | Generation of histocompatible tissues using nuclear transplantation |
JP2004221836A (ja) * | 2003-01-14 | 2004-08-05 | Ricoh Co Ltd | 画像処理装置、プログラム、記憶媒体及び符号伸長方法 |
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- 2001-12-21 AU AU2002232858A patent/AU2002232858B2/en not_active Expired
- 2001-12-21 EP EP01992388A patent/EP1356035B1/de not_active Expired - Lifetime
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- 2001-12-21 DE DE60144248T patent/DE60144248D1/de not_active Expired - Lifetime
- 2001-12-21 CA CA2427322A patent/CA2427322C/en not_active Expired - Lifetime
- 2001-12-21 WO PCT/US2001/050406 patent/WO2002051997A1/en active IP Right Grant
- 2001-12-21 CN CNB01820967XA patent/CN100448991C/zh not_active Expired - Lifetime
- 2001-12-21 JP JP2002553478A patent/JP4420604B2/ja not_active Expired - Lifetime
- 2001-12-21 KR KR1020037008319A patent/KR100832943B1/ko active IP Right Grant
- 2001-12-21 US US10/032,191 patent/US7253334B2/en not_active Expired - Lifetime
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- 2004-11-15 HK HK04109008.7A patent/HK1066028A1/xx not_active IP Right Cessation
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Also Published As
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---|---|
HK1066028A1 (en) | 2005-03-11 |
CN1498269A (zh) | 2004-05-19 |
JP2004516835A (ja) | 2004-06-10 |
EP1356035A1 (de) | 2003-10-29 |
JP4420604B2 (ja) | 2010-02-24 |
US20030046722A1 (en) | 2003-03-06 |
US7253334B2 (en) | 2007-08-07 |
KR100832943B1 (ko) | 2008-05-27 |
US20060212952A1 (en) | 2006-09-21 |
CA2427322C (en) | 2012-03-06 |
EP1356035B1 (de) | 2011-03-16 |
DE60144248D1 (de) | 2011-04-28 |
CA2427322A1 (en) | 2002-07-04 |
AU2002232858B2 (en) | 2007-01-11 |
EP1356035A4 (de) | 2004-07-28 |
NZ525607A (en) | 2005-05-27 |
MXPA03005624A (es) | 2004-12-03 |
WO2002051997A1 (en) | 2002-07-04 |
CN100448991C (zh) | 2009-01-07 |
KR20030082555A (ko) | 2003-10-22 |
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