PL3019516T3 - Objaśnienie optymalizacji wprowadzania w chromatografii jonowymiennej - Google Patents

Objaśnienie optymalizacji wprowadzania w chromatografii jonowymiennej

Info

Publication number
PL3019516T3
PL3019516T3 PL14745049T PL14745049T PL3019516T3 PL 3019516 T3 PL3019516 T3 PL 3019516T3 PL 14745049 T PL14745049 T PL 14745049T PL 14745049 T PL14745049 T PL 14745049T PL 3019516 T3 PL3019516 T3 PL 3019516T3
Authority
PL
Poland
Prior art keywords
elucidation
ion exchange
exchange chromatography
input optimization
chromatography input
Prior art date
Application number
PL14745049T
Other languages
English (en)
Inventor
Daniel Mcdonald
Thomas PATAPOFF
Yajun Wang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PL3019516T3 publication Critical patent/PL3019516T3/pl

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8658—Optimising operation parameters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3847—Multimodal interactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
PL14745049T 2013-07-12 2014-07-11 Objaśnienie optymalizacji wprowadzania w chromatografii jonowymiennej PL3019516T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361845890P 2013-07-12 2013-07-12
PCT/US2014/046338 WO2015006686A1 (en) 2013-07-12 2014-07-11 Elucidation of ion exchange chromatography input optimization
EP14745049.8A EP3019516B1 (en) 2013-07-12 2014-07-11 Elucidation of ion exchange chromatography input optimization

Publications (1)

Publication Number Publication Date
PL3019516T3 true PL3019516T3 (pl) 2019-04-30

Family

ID=51257626

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14745049T PL3019516T3 (pl) 2013-07-12 2014-07-11 Objaśnienie optymalizacji wprowadzania w chromatografii jonowymiennej

Country Status (19)

Country Link
US (2) US10274466B2 (pl)
EP (2) EP3019516B1 (pl)
JP (2) JP6462681B2 (pl)
KR (1) KR102251127B1 (pl)
CN (1) CN105377873B (pl)
AU (1) AU2014287044B2 (pl)
BR (1) BR112016000231A8 (pl)
CA (1) CA2918052A1 (pl)
ES (1) ES2705700T3 (pl)
HK (1) HK1222183A1 (pl)
HR (1) HRP20190071T1 (pl)
IL (1) IL243305B (pl)
MX (1) MX368107B (pl)
PL (1) PL3019516T3 (pl)
RU (1) RU2016104542A (pl)
SG (1) SG11201600221YA (pl)
SI (1) SI3019516T1 (pl)
TR (1) TR201818966T4 (pl)
WO (1) WO2015006686A1 (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015006686A1 (en) 2013-07-12 2015-01-15 Genentech, Inc. Elucidation of ion exchange chromatography input optimization
CN107110835B (zh) * 2014-11-12 2019-07-26 通用电气健康护理生物科学股份公司 用于确定实验参数对液相色谱协议的影响的方法和系统
GB2539420B (en) * 2015-06-16 2021-01-13 Cytiva Sweden Ab Determination of chromatography conditions
KR20200139720A (ko) * 2018-04-02 2020-12-14 암젠 인크 에레누맙 조성물 및 이의 용도
JP2021530247A (ja) * 2018-07-05 2021-11-11 オベーション ダイアグノスティクス エルエルシー 癌の診断のためのＢＣｌ−２抗体とイムノアッセイ
KR20200080748A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 음이온 교환 크로마토그래피를 이용한 인슐린 전구체의 정제방법

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2413974A1 (fr) 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4666855A (en) * 1985-07-31 1987-05-19 Massachusetts Institute Of Technology Rapid method for determining the isoelectric point for amphoteric molecules
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
DE3876273T2 (de) 1987-04-11 1993-05-27 Ciba Geigy Ag Isoelektrisches fokussierverfahren sowie einrichtung zur durchfuehrung dieses verfahrens.
CA1338518C (en) 1987-09-23 1996-08-13 Joyce M. Zarling Antibody heteroconjugates for the killing of hiv-infected cells
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
DE69029036T2 (de) 1989-06-29 1997-05-22 Medarex Inc Bispezifische reagenzien für die aids-therapie
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
JPH06500011A (ja) 1990-06-29 1994-01-06 ラージ　スケール　バイオロジー　コーポレイション 形質転換された微生物によるメラニンの製造
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
EP0586505A1 (en) 1991-05-14 1994-03-16 Repligen Corporation Heteroconjugate antibodies for treatment of hiv infection
ES2206447T3 (es) 1991-06-14 2004-05-16 Genentech, Inc. Anticuerpo humanizado para heregulina.
IE922437A1 (en) 1991-07-25 1993-01-27 Idec Pharma Corp Recombinant antibodies for human therapy
US7018809B1 (en) 1991-09-19 2006-03-28 Genentech, Inc. Expression of functional antibody fragments
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
US5587458A (en) 1991-10-07 1996-12-24 Aronex Pharmaceuticals, Inc. Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
JPH07501451A (ja) 1991-11-25 1995-02-16 エンゾン・インコーポレイテッド 多価抗原結合タンパク質
AU675929B2 (en) 1992-02-06 1997-02-27 Curis, Inc. Biosynthetic binding protein for cancer marker
ATE244763T1 (de) 1992-02-11 2003-07-15 Cell Genesys Inc Erzielen von homozygotem durch zielgerichtete genetische ereignisse
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
ATE149570T1 (de) 1992-08-17 1997-03-15 Genentech Inc Bispezifische immunoadhesine
CA2149329C (en) 1992-11-13 2008-07-15 Darrell R. Anderson Therapeutic application of chimeric and radiolabeled antibodies to human b lymphocyte restricted differentiation antigen for treatment of b cell lymphoma
US5534615A (en) 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
US5789199A (en) 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US5712374A (en) 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
ATE321066T1 (de) 1998-05-06 2006-04-15 Genentech Inc Anti-her2 antikörperzusammensetzung
SE9803838D0 (sv) * 1998-11-09 1998-11-09 Knut Irgum A chromatography method and a column material useful in said method
IL127127A0 (en) 1998-11-18 1999-09-22 Peptor Ltd Small functional units of antibody heavy chain variable regions
US6451987B1 (en) * 1999-03-15 2002-09-17 Novo Nordisk A/S Ion exchange chromatography of proteins and peptides
CA2369591C (en) * 1999-04-05 2011-06-14 Emisphere Technologies, Inc. Disodium salts, monohydrate, and ethanol solvates
CA2447832C (en) 2000-12-22 2012-09-25 Jamshid Tanha Phage display libraries of human vh fragments
JP2005289809A (ja) 2001-10-24 2005-10-20 Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) 突然変異重鎖抗体
ES2629602T5 (es) 2002-09-11 2021-06-08 Genentech Inc Purificación de proteínas
CA2525880C (en) 2003-05-16 2011-10-11 Cryobiophysica, Inc. External gradient chromatofocusing
PT1639011E (pt) 2003-06-30 2009-01-20 Domantis Ltd Anticorpos (dab) de domínio único peguilados
US7906630B2 (en) 2004-04-27 2011-03-15 PerkinElmer Heath Sciences, Inc. Method for identifying peptides in a biological sample
JP5008564B2 (ja) * 2004-05-20 2012-08-22 ウオーターズ・テクノロジーズ・コーポレイシヨン 混合物中のタンパク質を同定する方法および装置
US20070142629A1 (en) * 2004-06-16 2007-06-21 Ciphergen Biosystems, Inc. Multichemistry fractionation
CA2577133A1 (en) 2004-08-19 2006-03-23 Genentech, Inc. Polypeptide variants with altered effector function
WO2006024497A1 (en) * 2004-08-30 2006-03-09 Lonza Biologics Plc. Affinity- plus ion exchange- chromatography for purifying antibodies
EP1791565B1 (en) 2004-09-23 2016-04-20 Genentech, Inc. Cysteine engineered antibodies and conjugates
JP2006087394A (ja) * 2004-09-27 2006-04-06 Wako Pure Chem Ind Ltd 核酸抽出方法および核酸抽出キット
GB0613753D0 (en) * 2006-07-11 2006-08-23 Norwegian Radium Hospital Res Method
JP2010089001A (ja) * 2008-10-07 2010-04-22 Japan Organo Co Ltd クロマト分離方法
EP2403874A1 (en) 2009-03-06 2012-01-11 Genentech, Inc. Antibody formulation
CA2768325C (en) * 2009-07-24 2019-10-29 F. Hoffmann-La Roche Ag Optimizing the production of antibodies
US9428548B2 (en) * 2009-09-01 2016-08-30 Genentech, Inc. Enhanced protein purification through a modified protein A elution
JP2013530406A (ja) * 2010-07-09 2013-07-25 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ クロマトグラフィー方法及びそれに使用される媒体
WO2012102104A1 (ja) * 2011-01-24 2012-08-02 シャープ株式会社 露光装置、液晶表示装置及びその製造方法
WO2012129680A1 (en) * 2011-03-31 2012-10-04 Apotex Technologies Inc. Prodrugs of d-gamma-glutamyl-d-tryptophan and d-gamma- glutamyl-l-tryptophan
CN105051528A (zh) 2012-11-15 2015-11-11 弗·哈夫曼-拉罗切有限公司 离子强度介导的pH梯度离子交换色谱
WO2015006686A1 (en) 2013-07-12 2015-01-15 Genentech, Inc. Elucidation of ion exchange chromatography input optimization

Also Published As

Publication number Publication date
KR20160030251A (ko) 2016-03-16
HRP20190071T1 (hr) 2019-02-22
SI3019516T1 (sl) 2019-02-28
US10921297B2 (en) 2021-02-16
IL243305B (en) 2019-09-26
WO2015006686A1 (en) 2015-01-15
WO2015006686A8 (en) 2018-10-04
US10274466B2 (en) 2019-04-30
US20190310234A1 (en) 2019-10-10
EP3019516A1 (en) 2016-05-18
ES2705700T3 (es) 2019-03-26
JP6462681B2 (ja) 2019-01-30
KR102251127B1 (ko) 2021-05-11
JP2016529489A (ja) 2016-09-23
MX2016000181A (es) 2016-03-09
TR201818966T4 (tr) 2019-01-21
AU2014287044B2 (en) 2020-02-06
US20160161455A1 (en) 2016-06-09
CA2918052A1 (en) 2015-01-15
CN105377873A (zh) 2016-03-02
HK1222183A1 (zh) 2017-06-23
JP2019090818A (ja) 2019-06-13
IL243305A0 (en) 2016-03-31
EP3019516B1 (en) 2018-11-14
CN105377873B (zh) 2021-03-30
EP3536699A1 (en) 2019-09-11
MX368107B (es) 2019-09-18
BR112016000231A8 (pt) 2019-12-31
RU2016104542A (ru) 2017-08-17
AU2014287044A1 (en) 2016-02-11
SG11201600221YA (en) 2016-02-26

Similar Documents

Publication Publication Date Title
IL244320B (en) Methods for implementing specific access control
HK1218352A1 (zh) 可互換的蓋系統
HRP20190071T1 (hr) Elucidacija optimizacije unosa kromatografijom ionske izmjene
EP2983804A4 (en) Ion exchange purification of mrna
EP2901307A4 (en) SYSTEM FOR TRACKING BASKETBALL DICES
GB2540483B (en) Improved lenses
GB201301764D0 (en) Actuation of fluid-filled lenses
GB201317467D0 (en) Magnetic glasses
PL3011415T3 (pl) Wprowadzane elektroniczne trasowanie
EP3036538C0 (en) MODIFICATION OF IONS
IL243414A0 (en) Affinity chromatography matrix
GB2530454B (en) Optimization of instruction groups across group boundaries
DK3050055T3 (da) Gengivelse af flerkanalsaudio ved anvendelse af interpolerede matricer
EP2969754A4 (en) DESIGN ENHANCER SYSTEM
EP3015449A4 (en) (meth)acrylate production system
HK1204437A1 (en) System of assembling at least three parts
GB201304776D0 (en) Ion modification
GB2508683B (en) Program execution optimization for multi-stage manycore processors
GB201301859D0 (en) Regeneration of an ion exchange column
GB2509808B (en) Improved lenses
GB2522739B (en) Charge-stripping of multiply-charged ions
EP3095483A4 (en) Radiotherapy spacer
TWM475581U (en) Analysis system of behavior
FI20135404A (fi) Prosessin optimointi
SG10201403600SA (en) Chromatography column