BR112016000231A8 - métodos para identificações de condições de separação com cromatografia de troca de íons e para análises de composições de polipeptídeos - Google Patents

métodos para identificações de condições de separação com cromatografia de troca de íons e para análises de composições de polipeptídeos Download PDF

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Publication number
BR112016000231A8
BR112016000231A8 BR112016000231A BR112016000231A BR112016000231A8 BR 112016000231 A8 BR112016000231 A8 BR 112016000231A8 BR 112016000231 A BR112016000231 A BR 112016000231A BR 112016000231 A BR112016000231 A BR 112016000231A BR 112016000231 A8 BR112016000231 A8 BR 112016000231A8
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Prior art keywords
separation conditions
analysis
methods
ion exchange
exchange chromatography
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BR112016000231A
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English (en)
Inventor
Mcdonald Daniel
Patapoff Thomas
Wang Yajun
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Genentech Inc
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Publication of BR112016000231A8 publication Critical patent/BR112016000231A8/pt

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8658—Optimising operation parameters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3847—Multimodal interactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Confectionery (AREA)

Abstract

a presente invenção refere-se a processos para determinação de condições de separação com cromatografia; por exemplo, se-paração de um polipeptídeo e suas vriantes de carga. a invenção tam-bém refere-se a processos para determinação de uma condição tam-pão para condições de separação com cromatografia. a invenção também refere-se a um processo robusto para análise de múltiplos produtos polipeptídeos.
BR112016000231A 2013-07-12 2014-07-11 métodos para identificações de condições de separação com cromatografia de troca de íons e para análises de composições de polipeptídeos BR112016000231A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361845890P 2013-07-12 2013-07-12
PCT/US2014/046338 WO2015006686A1 (en) 2013-07-12 2014-07-11 Elucidation of ion exchange chromatography input optimization

Publications (1)

Publication Number Publication Date
BR112016000231A8 true BR112016000231A8 (pt) 2019-12-31

Family

ID=51257626

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016000231A BR112016000231A8 (pt) 2013-07-12 2014-07-11 métodos para identificações de condições de separação com cromatografia de troca de íons e para análises de composições de polipeptídeos

Country Status (19)

Country Link
US (2) US10274466B2 (pt)
EP (2) EP3019516B1 (pt)
JP (2) JP6462681B2 (pt)
KR (1) KR102251127B1 (pt)
CN (1) CN105377873B (pt)
AU (1) AU2014287044B2 (pt)
BR (1) BR112016000231A8 (pt)
CA (1) CA2918052A1 (pt)
ES (1) ES2705700T3 (pt)
HK (1) HK1222183A1 (pt)
HR (1) HRP20190071T1 (pt)
IL (1) IL243305B (pt)
MX (1) MX368107B (pt)
PL (1) PL3019516T3 (pt)
RU (1) RU2016104542A (pt)
SG (1) SG11201600221YA (pt)
SI (1) SI3019516T1 (pt)
TR (1) TR201818966T4 (pt)
WO (1) WO2015006686A1 (pt)

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JP2021530247A (ja) * 2018-07-05 2021-11-11 オベーション ダイアグノスティクス エルエルシー 癌の診断のためのＢＣｌ−２抗体とイムノアッセイ
KR20200080748A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 음이온 교환 크로마토그래피를 이용한 인슐린 전구체의 정제방법

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Also Published As

Publication number Publication date
MX2016000181A (es) 2016-03-09
US20160161455A1 (en) 2016-06-09
EP3019516B1 (en) 2018-11-14
AU2014287044B2 (en) 2020-02-06
IL243305B (en) 2019-09-26
CN105377873B (zh) 2021-03-30
US20190310234A1 (en) 2019-10-10
MX368107B (es) 2019-09-18
US10274466B2 (en) 2019-04-30
JP6462681B2 (ja) 2019-01-30
WO2015006686A1 (en) 2015-01-15
CA2918052A1 (en) 2015-01-15
AU2014287044A1 (en) 2016-02-11
EP3019516A1 (en) 2016-05-18
TR201818966T4 (tr) 2019-01-21
ES2705700T3 (es) 2019-03-26
RU2016104542A (ru) 2017-08-17
SG11201600221YA (en) 2016-02-26
KR20160030251A (ko) 2016-03-16
SI3019516T1 (sl) 2019-02-28
KR102251127B1 (ko) 2021-05-11
PL3019516T3 (pl) 2019-04-30
EP3536699A1 (en) 2019-09-11
JP2019090818A (ja) 2019-06-13
IL243305A0 (en) 2016-03-31
HK1222183A1 (zh) 2017-06-23
JP2016529489A (ja) 2016-09-23
US10921297B2 (en) 2021-02-16
HRP20190071T1 (hr) 2019-02-22
WO2015006686A8 (en) 2018-10-04
CN105377873A (zh) 2016-03-02

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