AR067544A1 - Anticuerpos anti- cd79b e inmunoconjugados y metodos de uso de los mismos - Google Patents

Anticuerpos anti- cd79b e inmunoconjugados y metodos de uso de los mismos

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Publication number
AR067544A1
AR067544A1 ARP080103031A ARP080103031A AR067544A1 AR 067544 A1 AR067544 A1 AR 067544A1 AR P080103031 A ARP080103031 A AR P080103031A AR P080103031 A ARP080103031 A AR P080103031A AR 067544 A1 AR067544 A1 AR 067544A1
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AR
Argentina
Prior art keywords
sequence
hvr
identifier
methods
cd79b
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ARP080103031A
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Genentech Inc
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39929686&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR067544(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR067544A1 publication Critical patent/AR067544A1/es

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    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K31/537Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
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    • A61K47/6849Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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Abstract

Composiciones de anticuerpos inmunoconjugados que los comprenden para el tratamiento de tumores hematopoyéticos en mamíferos, así como los métodos para usar dichas composiciones de sustancias con el mismo objetivo. Reivindicacion 1: Un anticuerpo anti-CD79b que incluye: (a) al menos una secuencia HVR seleccionada entre el grupo formado por: (i) HVR-L1 que comprende la secuencia A1-A15, donde A1-A15 es KASQSVDYDGDSFLN (identificador de secuencia n°: 131), (ii) HVR-L2 que comprende la secuencia B1-B7, donde B1-B7 es AASNLES (identificador de secuencia n°: 132), (iii) HVR-L3 que comprende la secuencia C1-C9, donde C1-C9 es QQSNEDPLT (identificador de secuencia n°: 133), (iv) HVR-H1 que comprende la secuencia D1-D10, donde D1-D10 es GYTFSSYWIE (identificador de secuencia n°: 134), (v) HVR-H2 que comprende la secuencia E1-E18, donde E1-E18 es GEILPGGGDTNYNEIFKG (identificador de secuencia n°: 135); (vi) HVR-H3 que comprende la secuencia F1-F10, donde F1-F10 es TRRVPVYFDY (identificador de secuencia n°: 136); y (b) al menos una variante de la HVR, donde la variante de la HVR incluye la modificacion de al menos un residuo de la secuencia descrita en los identificadores de secuencia n°: 131, 132, 133, 134, 135 o136.
ARP080103031A 2007-07-16 2008-07-15 Anticuerpos anti- cd79b e inmunoconjugados y metodos de uso de los mismos AR067544A1 (es)

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SG183023A1 (en) 2012-08-30
MA31606B1 (fr) 2010-08-02
JP2014122222A (ja) 2014-07-03
ZA201000080B (en) 2012-09-26
US20090028856A1 (en) 2009-01-29
AU2008276140A1 (en) 2009-01-22
SI2474557T1 (sl) 2014-12-31
NZ583367A (en) 2012-10-26
PE20140614A1 (es) 2014-05-28
ES2381788T3 (es) 2012-05-31
CN101802012B (zh) 2014-08-06
HRP20120352T1 (hr) 2012-05-31
WO2009012268A1 (en) 2009-01-22
BRPI0812691A2 (pt) 2020-08-18
CL2008002085A1 (es) 2008-11-21
RU2511410C2 (ru) 2014-04-10
HK1171461A1 (zh) 2013-03-28
RS52305B (en) 2012-12-31
NO2020020I1 (no) 2020-07-15
BR122022005321B1 (pt) 2022-08-16
KR20120044383A (ko) 2012-05-07
IL219268A0 (en) 2012-06-28
RU2694688C2 (ru) 2019-07-16
CN103819560B (zh) 2017-01-04
NZ602024A (en) 2014-04-30
US20220251197A1 (en) 2022-08-11
CY2020021I1 (el) 2020-11-25
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MY150531A (en) 2014-01-30
RU2694688C3 (ru) 2021-11-16

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