PE20120080A1 - Anticuerpos anti-notch2 y metodos de uso - Google Patents

Anticuerpos anti-notch2 y metodos de uso

Info

Publication number
PE20120080A1
PE20120080A1 PE2011000807A PE2011000807A PE20120080A1 PE 20120080 A1 PE20120080 A1 PE 20120080A1 PE 2011000807 A PE2011000807 A PE 2011000807A PE 2011000807 A PE2011000807 A PE 2011000807A PE 20120080 A1 PE20120080 A1 PE 20120080A1
Authority
PE
Peru
Prior art keywords
seq
nos
methods
selected sequences
notch2
Prior art date
Application number
PE2011000807A
Other languages
English (en)
Inventor
Christian W Siebel
Yan Wu
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41349057&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120080(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE20120080A1 publication Critical patent/PE20120080A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

REFERIDA A UN ANTICUERPO MONOCLONAL QUE SEFIJA A Notch2 NRR CARACTERIZADA POR: A) UN HVR-H1 DE SECUENCIAS SELECCIONADAS DE SEQ ID NOS:1-2; B) HVR-L1 DE SECUENCIAS SELECCIONADAS DE SEQ ID NOS: 6-9; C) HVR-L2 DE SECUENCIAS SELECCIONADAS DE SEQ ID NOS: 11-13; D) HRV-L3 DE SECUENCIAS SELECCIONADAS DE SEQ ID NOS: 15-18. DICHO ANTICUERPO SE FIJA AL DOMINO LNR-A Y EL DOMINIO HD-C DE Notch2, SIENDO UTIL EN EL TRATAMIENTO DE MELANOMAS
PE2011000807A 2008-10-01 2009-09-30 Anticuerpos anti-notch2 y metodos de uso PE20120080A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10191708P 2008-10-01 2008-10-01

Publications (1)

Publication Number Publication Date
PE20120080A1 true PE20120080A1 (es) 2012-02-17

Family

ID=41349057

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011000807A PE20120080A1 (es) 2008-10-01 2009-09-30 Anticuerpos anti-notch2 y metodos de uso

Country Status (18)

Country Link
US (5) US8404239B2 (es)
EP (1) EP2334331B1 (es)
JP (2) JP5710487B2 (es)
KR (1) KR101712214B1 (es)
CN (1) CN102170909B (es)
AR (1) AR073717A1 (es)
AU (1) AU2009298569A1 (es)
BR (1) BRPI0913827A2 (es)
CA (1) CA2736429A1 (es)
CL (1) CL2011000711A1 (es)
ES (1) ES2541726T3 (es)
IL (1) IL211623A0 (es)
MX (1) MX2011002928A (es)
PE (1) PE20120080A1 (es)
RU (1) RU2580029C2 (es)
TW (1) TW201018484A (es)
WO (1) WO2010039832A1 (es)
ZA (1) ZA201101651B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
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US7919092B2 (en) 2006-06-13 2011-04-05 Oncomed Pharmaceuticals, Inc. Antibodies to notch receptors
CA2676008A1 (en) 2007-01-24 2008-07-31 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
MY155603A (en) 2008-07-08 2015-11-13 Oncomed Pharm Inc Notch-binding agents and antagonists and methods of use thereof
AR073717A1 (es) * 2008-10-01 2010-11-24 Genentech Inc Anticuerpos anti-notch2 de murino y humano, y metodos de uso
US8906649B2 (en) 2010-09-27 2014-12-09 Janssen Biotech, Inc. Antibodies binding human collagen II
EP3050899B1 (en) * 2010-09-27 2019-09-04 Janssen Biotech, Inc. Antibodies binding human collagen ii
US9663573B2 (en) 2011-10-05 2017-05-30 Genentech, Inc. Methods of treating liver conditions using Notch2 antagonists
JP2015517529A (ja) * 2012-05-16 2015-06-22 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｎｏｔｃｈ２／３抗体によって癌を治療するための方法
WO2014028446A1 (en) 2012-08-13 2014-02-20 Genentech, Inc. Anti-jagged anitbodies and methods of use
US9944700B2 (en) 2013-03-13 2018-04-17 Novartis Ag Notch2 binding molecules for treating respiratory diseases
JP6527132B2 (ja) 2013-03-15 2019-06-05 ジェネンテック， インコーポレイテッド 肝臓がんの診断及び治療のための組成物及び方法
AU2015217271B2 (en) 2014-02-12 2018-10-25 Genentech, Inc. Anti-Jagged1 antibodies and methods of use
EP3166627A1 (en) 2014-07-11 2017-05-17 Genentech, Inc. Notch pathway inhibition
CN108472201A (zh) * 2015-09-26 2018-08-31 财团法人卫生研究院 用于治疗掉发之方法及组成物
GB201521447D0 (en) * 2015-12-04 2016-01-20 Ucb Biopharma Sprl De novo antibody design
WO2018222880A1 (en) * 2017-05-31 2018-12-06 Trustees Of Boston University Mechano-activated control of gene expression
AU2021308653A1 (en) * 2020-07-17 2023-02-16 Genentech, Inc. Anti-Notch2 antibodies and methods of use

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Also Published As

Publication number Publication date
RU2011117237A (ru) 2012-11-10
TW201018484A (en) 2010-05-16
AU2009298569A1 (en) 2010-04-08
EP2334331B1 (en) 2015-04-29
JP2015145379A (ja) 2015-08-13
CL2011000711A1 (es) 2012-07-20
ZA201101651B (en) 2012-06-27
IL211623A0 (en) 2011-05-31
CN102170909B (zh) 2015-11-25
RU2580029C2 (ru) 2016-04-10
CN102170909A (zh) 2011-08-31
JP2012504634A (ja) 2012-02-23
JP5710487B2 (ja) 2015-04-30
CA2736429A1 (en) 2010-04-08
KR101712214B1 (ko) 2017-03-03
US20170204175A9 (en) 2017-07-20
US20100080808A1 (en) 2010-04-01
KR20110061600A (ko) 2011-06-09
US20150104461A1 (en) 2015-04-16
US8404239B2 (en) 2013-03-26
US20140037643A1 (en) 2014-02-06
EP2334331A1 (en) 2011-06-22
MX2011002928A (es) 2011-04-11
US20140314782A1 (en) 2014-10-23
AR073717A1 (es) 2010-11-24
BRPI0913827A2 (pt) 2020-12-29
ES2541726T3 (es) 2015-07-23
US20180057589A1 (en) 2018-03-01
WO2010039832A1 (en) 2010-04-08

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