PE20180317A1 - Anticuerpos anti-tau y metodos de uso - Google Patents
Anticuerpos anti-tau y metodos de usoInfo
- Publication number
- PE20180317A1 PE20180317A1 PE2017002517A PE2017002517A PE20180317A1 PE 20180317 A1 PE20180317 A1 PE 20180317A1 PE 2017002517 A PE2017002517 A PE 2017002517A PE 2017002517 A PE2017002517 A PE 2017002517A PE 20180317 A1 PE20180317 A1 PE 20180317A1
- Authority
- PE
- Peru
- Prior art keywords
- hvr
- seq
- nos
- sequence
- amino acids
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 abstract 5
- 230000003930 cognitive ability Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Abstract
Se refiere a un anticuerpos anti-Tau que comprende los HVRs seleccionados entre: (a) HVR-H1 que comprende las SEQ N°: 12, 22, 282, 292 y 342; HVR-H2 que comprende una secuencia de aminoacidos seleccionadas entre SEC ID Nos: 13, 23, 283, entre otros; (c) HVR-H3 que comprende una secuencia de aminoacidos seleccionadas entre SEC ID Nos: 14, 24, y 284 entre otros; (d) HVR-L1 que comprende una secuencia de aminoacidos seleccionadas entre SEC ID Nos: 15, 25, 285, entre otros; y HVR-L2 que comprende una secuencia de aminoacidos seleccionadas entre SEC ID Nos: 16, 26, 286, entre otros; y (f) HVR-L3 que comprende una secuencia de aminoacidos seleccionadas entre SEC ID Nos: 17, 27, 287, entre otros. Estos se usan como metodo para retener o aumentar la capacidad cognitiva o desaceleracion de memoria; entre otras.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562171693P | 2015-06-05 | 2015-06-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20180317A1 true PE20180317A1 (es) | 2018-02-09 |
Family
ID=56118083
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2017002517A PE20180317A1 (es) | 2015-06-05 | 2016-06-02 | Anticuerpos anti-tau y metodos de uso |
Country Status (23)
Country | Link |
---|---|
US (6) | US10112990B2 (es) |
EP (1) | EP3303386A1 (es) |
JP (3) | JP6793134B2 (es) |
KR (1) | KR20180014764A (es) |
CN (2) | CN107849124B (es) |
AR (1) | AR104875A1 (es) |
AU (2) | AU2016270858B2 (es) |
CA (1) | CA2986942A1 (es) |
CL (2) | CL2017003063A1 (es) |
CO (1) | CO2018000046A2 (es) |
CR (1) | CR20180013A (es) |
HK (1) | HK1249531A1 (es) |
IL (2) | IL300670A (es) |
MA (1) | MA44955A (es) |
MX (3) | MX2017015464A (es) |
PE (1) | PE20180317A1 (es) |
PH (1) | PH12017502165A1 (es) |
RU (1) | RU2732122C2 (es) |
SG (1) | SG10201911349YA (es) |
TW (3) | TWI827405B (es) |
UA (1) | UA126272C2 (es) |
WO (1) | WO2016196726A1 (es) |
ZA (3) | ZA201707644B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
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SG10201707855YA (en) | 2013-03-13 | 2017-10-30 | Prothena Biosciences Ltd | Tau immunotherapy |
MA41867A (fr) | 2015-04-01 | 2018-02-06 | Anaptysbio Inc | Anticorps dirigés contre l'immunoglobuline de cellule t et protéine 3 de mucine (tim-3) |
AR104875A1 (es) | 2015-06-05 | 2017-08-23 | Genentech Inc | Anticuerpos anti-tau y métodos de uso |
KR20180027566A (ko) | 2015-07-06 | 2018-03-14 | 유씨비 바이오파마 에스피알엘 | 타우 결합 항체 |
PE20190261A1 (es) | 2016-05-02 | 2019-02-25 | Prothena Biosciences Ltd | Anticuerpos que reconocen tau |
CN109415432B (zh) | 2016-05-02 | 2022-07-08 | 普罗塞纳生物科学有限公司 | Tau免疫疗法 |
EP3535586A4 (en) | 2016-11-01 | 2020-08-05 | AnaptysBio, Inc. | ANTIBODIES DIRECTED AGAINST T CELL IMMUNOGUE LOBULIN AND MUCIN PROTEIN 3 (TIM-3) |
AU2017373884A1 (en) * | 2016-12-07 | 2019-05-30 | Ac Immune Sa | Anti-tau antibodies and methods of their use |
AR110321A1 (es) | 2016-12-07 | 2019-03-20 | Genentech Inc | Anticuerpos antitau y métodos de uso |
MA47499A (fr) * | 2017-02-17 | 2019-12-25 | Denali Therapeutics Inc | Anticorps anti-tau et leurs procédés d'utilisation |
EP3601337A1 (en) * | 2017-03-28 | 2020-02-05 | Genentech, Inc. | Methods of treating neurodegenerative diseases |
BR112019022906A2 (pt) * | 2017-05-02 | 2020-05-26 | Prothena Biosciences Limited | Anticorpos que reconhecem tau |
WO2019018828A1 (en) * | 2017-07-20 | 2019-01-24 | Cytomx Therapeutics, Inc. | METHODS OF QUALITATIVE AND / OR QUANTITATIVE ANALYSIS OF ACTIVATABLE ANTIBODY PROPERTIES AND USES THEREOF |
JP6851549B2 (ja) | 2017-10-16 | 2021-03-31 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 抗タウ抗体及びその使用 |
JP2021501147A (ja) | 2017-10-25 | 2021-01-14 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | リン酸化タウペプチドの組成物およびその使用 |
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US20200408781A1 (en) * | 2018-03-05 | 2020-12-31 | Gallen Triana-Baltzer | Assays to detect neurodegeneration |
CN112105639A (zh) | 2018-03-05 | 2020-12-18 | 詹森药业有限公司 | 抗PHF-tau抗体及其用途 |
US11306151B2 (en) * | 2018-03-08 | 2022-04-19 | Phanes Therapeutics, Inc. | Anti-TIP-1 antibodies and uses thereof |
JOP20210098A1 (ar) * | 2018-11-08 | 2023-01-30 | Prothena Biosciences Ltd | أجسام مضادة تتعرف على تاو |
EA202192203A1 (ru) | 2019-02-08 | 2021-10-20 | Ац Иммуне С.А. | СПОСОБ БЕЗОПАСНОГО ВВЕДЕНИЯ ВАКЦИНЫ ФОСФОРИЛИРОВАННОГО ПЕПТИДА Tau |
PE20211709A1 (es) * | 2019-02-08 | 2021-09-01 | Prothena Biosciences Ltd | Anticuerpos que reconocen tau |
CU20210073A7 (es) | 2019-03-03 | 2022-04-07 | Prothena Biosciences Ltd | Anticuerpos que se unen dentro de la región de unión a microtúbulos de tau definida por cdrs |
CN114173812A (zh) | 2019-04-24 | 2022-03-11 | 杨森制药公司 | Tau疫苗的异源给予 |
CN114174515A (zh) * | 2019-05-27 | 2022-03-11 | 英属哥伦比亚大学 | tau中的构象特异性表位、其抗体和其相关方法 |
JP7227895B2 (ja) * | 2019-12-23 | 2023-02-22 | 株式会社堀場製作所 | 相互作用検出方法、相互作用検出装置及びバイオチップ再生キット |
CN113005096B (zh) * | 2021-01-19 | 2022-10-14 | 华中科技大学 | 分泌抗丝氨酸磷酸化tau蛋白单克隆抗体的杂交瘤细胞株 |
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